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Koyanagi Naoto  小柳 直人

ORCIDConnect your ORCID iD *help
Researcher Number 90738121
Other IDs
Affiliation (based on the past Project Information) *help 2023 – 2024: 東京大学, 医科学研究所, 助教
2022: 福島県立医科大学, 保健科学部, 助教
2018 – 2021: 東京大学, 医科学研究所, 助教
Review Section/Research Field
Principal Investigator
Basic Section 49060:Virology-related
Keywords
Principal Investigator
HSV / 免疫回避 / 脳炎 / MHC-I / CTL / HSV-2 / 単純ヘルペスウイルス / NKG2Dリガンド / 感染制御 / 障害回避 / 回避機構 / NK細胞
  • Research Projects

    (3 results)
  • Research Products

    (28 results)
  • Co-Researchers

    (3 People)
  •  単純ヘルペス脳炎発症機構の解明Principal Investigator

    • Principal Investigator
      小柳 直人
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49060:Virology-related
    • Research Institution
      The University of Tokyo
  •  Novel CTL evasion mechanism of HSV-2Principal Investigator

    • Principal Investigator
      Koyanagi Naoto
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 49060:Virology-related
    • Research Institution
      The University of Tokyo
      Fukushima Medical University
  •  Elucidation of NK cell evasion mechanism by herpes simplex virusPrincipal Investigator

    • Principal Investigator
      Koyanagi Naoto
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 49060:Virology-related
    • Research Institution
      The University of Tokyo

All 2024 2023 2022 2020 2018

All Journal Article Presentation

  • [Journal Article] Identification of a novel neurovirulence factor encoded by the cryptic orphan gene UL31.6 of herpes simplex virus 12024

    • Author(s)
      Kato Akihisa、Iwasaki Ryoji、Takeshima Kousuke、Maruzuru Yuhei、Koyanagi Naoto、Natsume Tohru、Kusano Hideo、Adachi Shungo、Kawano Shuichi、Kawaguchi Yasushi
    • Journal Title

      Journal of Virology

      Volume: 98 Issue: 7

    • DOI

      10.1128/jvi.00747-24

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H05692, KAKENHI-PROJECT-22K15468, KAKENHI-PROJECT-23K06562, KAKENHI-PROJECT-23K07919, KAKENHI-PROJECT-23K18210, KAKENHI-PROJECT-24K18448
  • [Journal Article] MYBBP1A is required for efficient replication and gene expression of herpes simplex virus 12024

    • Author(s)
      Nobe Moeka、Maruzuru Yuhei、Takeshima Kosuke、Koyanagi Naoto、Kato Akihisa、Kawaguchi Yasushi
    • Journal Title

      Microbiology and Immunology

      Volume: 68 Issue: 4 Pages: 148-154

    • DOI

      10.1111/1348-0421.13120

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07511, KAKENHI-PROJECT-21K19370, KAKENHI-PROJECT-21K19498, KAKENHI-PROJECT-20H03492, KAKENHI-PUBLICLY-22H04803, KAKENHI-PUBLICLY-22H05584, KAKENHI-PROJECT-20H05692, KAKENHI-PROJECT-22K15468, KAKENHI-PROJECT-23K06562, KAKENHI-PROJECT-23K07919, KAKENHI-PROJECT-23K18210, KAKENHI-PROJECT-24K18448
  • [Journal Article] Impact of the interaction between herpes simplex virus 1 ICP22 and FACT on viral gene expression and pathogenesis2024

    • Author(s)
      Liu Shaocong、Maruzuru Yuhei、Takeshima Kosuke、Koyanagi Naoto、Kato Akihisa、Kawaguchi Yasushi
    • Journal Title

      Journal of Virology

      Volume: 98 Issue: 8

    • DOI

      10.1128/jvi.00737-24

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H05692, KAKENHI-PROJECT-22K15468, KAKENHI-PROJECT-23K06562, KAKENHI-PROJECT-23K07919, KAKENHI-PROJECT-23K18210, KAKENHI-PROJECT-24K18448
  • [Journal Article] Role of the Arginine Cluster in the Disordered Domain of Herpes Simplex Virus 1 UL34 for the Recruitment of ESCRT-III for Viral Primary Envelopment2022

    • Author(s)
      Arii Jun、Takeshima Kosuke、Maruzuru Yuhei、Koyanagi Naoto、Nakayama Yoshitaka、Kato Akihisa、Mori Yasuko、Kawaguchi Yasushi
    • Journal Title

      Journal of Virology

      Volume: 96 Issue: 2

    • DOI

      10.1128/jvi.01704-21

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-21H00417, KAKENHI-PROJECT-20K07511, KAKENHI-PROJECT-21K19370, KAKENHI-PROJECT-21K15447, KAKENHI-PROJECT-21K19498, KAKENHI-PUBLICLY-22H05584, KAKENHI-PROJECT-20H05692, KAKENHI-PROJECT-20H03492, KAKENHI-PROJECT-20H03496, KAKENHI-PUBLICLY-21H00338
  • [Journal Article] Phosphoregulation of a Conserved Herpesvirus Tegument Protein by a Virally Encoded Protein Kinase in Viral Pathogenicity and Potential Linkage between Its Evolution and Viral Phylogeny2020

    • Author(s)
      Shibazaki Misato、Kato Akihisa、Takeshima Kosuke、Ito Jumpei、Suganami Mai、Koyanagi Naoto、Maruzuru Yuhei、Sato Kei、Kawaguchi Yasushi
    • Journal Title

      Journal of Virology

      Volume: 94 Issue: 18 Pages: 1-4

    • DOI

      10.1128/jvi.01055-20

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07511, KAKENHI-PROJECT-19K22524, KAKENHI-PROJECT-20K15767, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-PROJECT-17H04080, KAKENHI-PROJECT-17H05069, KAKENHI-PUBLICLY-19H04826, KAKENHI-PUBLICLY-20H04899, KAKENHI-PROJECT-18H02662, KAKENHI-PROJECT-19J01713, KAKENHI-PROJECT-18K15164, KAKENHI-PROJECT-19K21256, KAKENHI-ORGANIZER-16H06429, KAKENHI-PROJECT-20H03492, KAKENHI-ORGANIZER-15H05935, KAKENHI-WRAPUP-20H05615
  • [Journal Article] Role of the DNA Binding Activity of Herpes Simplex Virus 1 VP22 in Evading AIM2-Dependent Inflammasome Activation Induced by the Virus2020

    • Author(s)
      Maruzuru Yuhei、Koyanagi Naoto、Kato Akihisa、Kawaguchi Yasushi
    • Journal Title

      Journal of Virology

      Volume: 95 Issue: 5

    • DOI

      10.1128/jvi.02172-20

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07511, KAKENHI-PROJECT-17H04080, KAKENHI-PROJECT-17H05069, KAKENHI-PROJECT-18K15164, KAKENHI-PROJECT-19K21256, KAKENHI-PLANNED-16H06433, KAKENHI-PROJECT-20H05692, KAKENHI-PROJECT-20H03492, KAKENHI-PUBLICLY-20H04899, KAKENHI-PUBLICLY-21H00338, KAKENHI-PROJECT-21K19498
  • [Journal Article] Role of Phosphatidylethanolamine Biosynthesis in Herpes Simplex Virus 1-Infected Cells in Progeny Virus Morphogenesis in the Cytoplasm and in Viral Pathogenicity In Vivo2020

    • Author(s)
      Arii Jun、Fukui Ayano、Shimanaka Yuta、Kono Nozomu、Arai Hiroyuki、Maruzuru Yuhei、Koyanagi Naoto、Kato Akihisa、Mori Yasuko、Kawaguchi Yasushi
    • Journal Title

      Journal of Virology

      Volume: 94 Issue: 24

    • DOI

      10.1128/jvi.01572-20

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K07511, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-PROJECT-17H04080, KAKENHI-PROJECT-17H05069, KAKENHI-PUBLICLY-19H05286, KAKENHI-PUBLICLY-19H05417, KAKENHI-PUBLICLY-20H04899, KAKENHI-PROJECT-17K08851, KAKENHI-PROJECT-18K15164, KAKENHI-PROJECT-19K21256, KAKENHI-ORGANIZER-16H06429, KAKENHI-PLANNED-17H06418, KAKENHI-PROJECT-17H06164, KAKENHI-PROJECT-20H05692, KAKENHI-PROJECT-20H03380, KAKENHI-PROJECT-20H03492, KAKENHI-PROJECT-20H03496
  • [Journal Article] Prohibitin-1 Contributes to Cell-to-Cell Transmission of Herpes Simplex Virus 1 via the MAPK/ERK Signaling Pathway2020

    • Author(s)
      Watanabe Mizuki、Arii Jun、Takeshima Kosuke、Fukui Ayano、Shimojima Masayuki、Kozuka-Hata Hiroko、Oyama Masaaki、Minamitani Takeharu、Yasui Teruhito、Kubota Yuji、Takekawa Mutsuhiro、Kosugi Isao、Maruzuru Yuhei、Koyanagi Naoto、Kato Akihisa、Mori Yasuko、Kawaguchi Yasushi
    • Journal Title

      Journal of Virology

      Volume: 95 Issue: 3

    • DOI

      10.1128/jvi.01413-20

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07511, KAKENHI-PROJECT-17H04080, KAKENHI-PROJECT-17H05069, KAKENHI-ORGANIZER-16H06573, KAKENHI-PLANNED-16H06574, KAKENHI-PLANNED-16H06578, KAKENHI-PUBLICLY-19H05286, KAKENHI-PUBLICLY-19H05417, KAKENHI-PROJECT-18H02609, KAKENHI-PROJECT-17K08851, KAKENHI-PROJECT-18K15164, KAKENHI-PROJECT-19K21256, KAKENHI-PROJECT-20H05692, KAKENHI-PROJECT-20H03496, KAKENHI-PUBLICLY-20H04899, KAKENHI-PUBLICLY-21H00338, KAKENHI-PROJECT-21H02692, KAKENHI-PROJECT-21K07816, KAKENHI-PROJECT-21K19498, KAKENHI-INTERNATIONAL-16K21739
  • [Journal Article] ESCRT-III controls nuclear envelope deformation induced by progerin2020

    • Author(s)
      Arii Jun、Maeda Fumio、Maruzuru Yuhei、Koyanagi Naoto、Kato Akihisa、Mori Yasuko、Kawaguchi Yasushi
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 18877-18877

    • DOI

      10.1038/s41598-020-75852-6

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07511, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-PROJECT-17H04080, KAKENHI-PROJECT-17H05069, KAKENHI-PUBLICLY-19H05286, KAKENHI-PUBLICLY-19H05417, KAKENHI-PUBLICLY-20H04899, KAKENHI-PROJECT-17K08851, KAKENHI-PROJECT-18K15164, KAKENHI-PROJECT-19K21256, KAKENHI-ORGANIZER-16H06429, KAKENHI-PROJECT-20H05692, KAKENHI-PROJECT-20H03492, KAKENHI-PROJECT-20H03496
  • [Journal Article] Identification of a herpes simplex virus 1 gene encoding neurovirulence factor by chemical proteomics2020

    • Author(s)
      Kato Akihisa、Adachi Shungo、Kawano Shuichi、Takeshima Kousuke、Watanabe Mizuki、Kitazume Shinobu、Sato Ryota、Kusano Hideo、Koyanagi Naoto、Maruzuru Yuhei、Arii Jun、Hatta Tomohisa、Natsume Tohru、Kawaguchi Yasushi
    • Journal Title

      Nature Communications

      Volume: 11 Issue: 1 Pages: 4894-4894

    • DOI

      10.1038/s41467-020-18718-9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07511, KAKENHI-PROJECT-19K22524, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-PROJECT-17H04080, KAKENHI-PROJECT-17H05069, KAKENHI-PUBLICLY-20H04899, KAKENHI-PROJECT-18K15164, KAKENHI-PROJECT-19K21256, KAKENHI-ORGANIZER-16H06429, KAKENHI-PLANNED-16H06433, KAKENHI-PROJECT-20H05692, KAKENHI-PROJECT-20H03492, KAKENHI-PROJECT-19K16685, KAKENHI-PUBLICLY-21H00338, KAKENHI-ORGANIZER-15H05935, KAKENHI-WRAPUP-20H05615
  • [Journal Article] Evasion of the Cell-Mediated Immune Response by Alphaherpesviruses2020

    • Author(s)
      Koyanagi Naoto、Kawaguchi Yasushi
    • Journal Title

      Viruses

      Volume: 12 Issue: 12 Pages: 1354-1354

    • DOI

      10.3390/v12121354

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K15164, KAKENHI-PROJECT-20H05692
  • [Journal Article] ESCRT-III mediates budding across the inner nuclear membrane and regulates its integrity.2018

    • Author(s)
      Arii J, Watanabe M, Maeda F, Tokai-Nishizumi N, Chihara T, Miura M, Maruzuru Y, Koyanagi N, Kato A, Kawaguchi Y.
    • Journal Title

      Nat Commun.

      Volume: 9 Issue: 1 Pages: 3379-3379

    • DOI

      10.1038/s41467-018-05889-9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08851, KAKENHI-PROJECT-17K19549, KAKENHI-PROJECT-18K15164, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-ORGANIZER-16H06429, KAKENHI-PLANNED-16H06433, KAKENHI-PUBLICLY-18H04968, KAKENHI-PROJECT-16K15280, KAKENHI-PROJECT-17H04080, KAKENHI-PROJECT-17H05069, KAKENHI-PROJECT-19K21256
  • [Journal Article] Regulation of Herpes Simplex Virus 2 Protein Kinase UL13 by Phosphorylation and Its Role in Viral Pathogenesis.2018

    • Author(s)
      Koyanagi N, Kato A, Takeshima K, Maruzuru Y, Kozuka-Hata H, Oyama M, Arii J, Kawaguchi Y.
    • Journal Title

      J Virol.

      Volume: 92 Issue: 17

    • DOI

      10.1128/jvi.00807-18

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08851, KAKENHI-PROJECT-17K19549, KAKENHI-PROJECT-18K15164, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-ORGANIZER-16H06429, KAKENHI-PLANNED-16H06433, KAKENHI-PLANNED-16H06578, KAKENHI-PUBLICLY-18H04968, KAKENHI-PROJECT-17H04080, KAKENHI-PROJECT-17H05069, KAKENHI-PROJECT-19K21256
  • [Journal Article] Roles of the Phosphorylation of Herpes Simplex Virus 1 UL51 at a Specific Site in Viral Replication and Pathogenicity.2018

    • Author(s)
      Kato A, Oda S, Watanabe M, Oyama M, Kozuka-Hata H, Koyanagi N, Maruzuru Y, Arii J, Kawaguchi Y.
    • Journal Title

      J Virol.

      Volume: 92 Issue: 18

    • DOI

      10.1128/jvi.01035-18

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08851, KAKENHI-PROJECT-17K19549, KAKENHI-PROJECT-18K15164, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-ORGANIZER-16H06429, KAKENHI-PLANNED-16H06433, KAKENHI-PLANNED-16H06578, KAKENHI-PUBLICLY-18H04968, KAKENHI-PROJECT-17H04080, KAKENHI-PROJECT-17H05069, KAKENHI-PROJECT-19K21256, KAKENHI-ORGANIZER-15H05935
  • [Presentation] 単純ヘルペスウイルスがコードするuracil-DNA-glycosylase機能の再定義2024

    • Author(s)
      加藤哲久, 播磨勇人, 竹島功高, 丸鶴雄平, 小柳直人, 稲田利文, 岡田尚巳, 村松正道, 川口寧
    • Organizer
      第71回日本ウイルス学会学術集会
    • Data Source
      KAKENHI-PROJECT-23K06562
  • [Presentation] Evasion of APOBEC1-mediated intrinsic Immunity by a herpesvirus uracil DNA glycosylase is a Determinant of viral encephalitis2024

    • Author(s)
      Akihisa Kato, Hayato Harima, Kousuke Takeshima, Yuhei Maruzuru, Naoto Koyanagi, Masamichi Muramatsu, Yasushi Kawaguchi
    • Organizer
      48th Annual International Herpesvirus Workshop
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K06562
  • [Presentation] Impact of the interaction between herpes simplex virus 1 ICP22 and FACT on viral gene expression and pathogenesis2024

    • Author(s)
      Shaocong Liu, Yuhei Maruzuru, Kosuke Takeshima, Naoto Koyanagi, Akihisa Kato, Yasushi Kawaguchi
    • Organizer
      48th Annual International Herpesvirus Workshop
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K06562
  • [Presentation] Ala-326が司るHSV-1 Us3リン酸化制御機構におけるintegrityの重要性2024

    • Author(s)
      塩さおり, 加藤哲久, 竹島功高, 丸鶴雄平, 小柳直人, 播磨勇人, 川口寧
    • Organizer
      第71回日本ウイルス学会学術集会
    • Data Source
      KAKENHI-PROJECT-23K06562
  • [Presentation] Regulatory mimicry of cyclin-dependent kinases by conserved herpesvirus protein kinases2023

    • Author(s)
      Naoto Koyanagi, Akihisa Kato, Kosuke Takeshima, Yuhei Maruzuru and Yasushi Kawaguchi
    • Organizer
      International Herpesvirus Workshop 2023
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K15447
  • [Presentation] Role of amino acid residues in the α-helix 9 of HSV-1 UL31 in its interaction with capsid proteins and nuclear egress2018

    • Author(s)
      Kosuke Takeshima, Jun Arii, Yuhei Maruzuru, Naoto Koyanagi, Akihisa Kato, Yasushi Kawaguchi
    • Organizer
      43nd Annual International Herpesvirus Workshop
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15164
  • [Presentation] Primary Envelopment におけるHSV-1 UL31 α-helix 9 の役割2018

    • Author(s)
      竹島 功高,有井 潤,丸鶴 雄平,小柳 直人,加藤 哲久,川口 寧
    • Organizer
      第32回ヘルペスウイルス研究会
    • Data Source
      KAKENHI-PROJECT-18K15164
  • [Presentation] αヘルペスウイルスの進化とUs3 リン酸化部位の獲得2018

    • Author(s)
      柴崎 美里,加藤 哲久,竹島 功高,丸鶴 雄平,小柳 直人,有井 潤,川口 寧
    • Organizer
      第32回ヘルペスウイルス研究会
    • Data Source
      KAKENHI-PROJECT-18K15164
  • [Presentation] HSV type-specific phosphorylation mediated by Us3 kinase: its role in viral pathogenesis and implication in evolution of herpesviruses2018

    • Author(s)
      Misato Shibazaki,Akihisa Kato,Kosuke Takeshima,Naoto Koyanagi,Yuhei Maruzuru, Jun Arii,Yasushi Kawaguchi
    • Organizer
      第66回日本ウイルス学会学術集会
    • Data Source
      KAKENHI-PROJECT-18K15164
  • [Presentation] Negative regulation of HSV-1 Us3 kinase by tyrosine phosphorylation and its role in viral replication and pathogenesis2018

    • Author(s)
      Nami Kimura,Akihisa Kato,Yuhei Maruzuru,Naoto Koyanagi,Jun Arii,Yasushi Kawaguchi
    • Organizer
      第66回日本ウイルス学会学術集会
    • Data Source
      KAKENHI-PROJECT-18K15164
  • [Presentation] A single amino acid substitution in HSV-1 UL31 at an inter-hexamer contact site abrogates primary envelopment and viral growth2018

    • Author(s)
      Jun Arii,Kosuke Takeshima,Yuhei Maruzuru,Naoto Koyanagi,Akihisa Kato, Yasushi Kawaguchi
    • Organizer
      第66回日本ウイルス学会学術集会
    • Data Source
      KAKENHI-PROJECT-18K15164
  • [Presentation] A single amino acid substitution in herpes simplex virus 1 UL31 at an inter-hexamer contact site abrogates primary envelopment and viral growth2018

    • Author(s)
      Jun Arii, Kosuke Takeshima, Yuhei Maruzuru, Naoto Koyanagi, Akihisa Kato, Yasushi Kawaguchi
    • Organizer
      43nd Annual International Herpesvirus Workshop
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15164
  • [Presentation] Residues in α-helix 9 of HSV-1 UL31 is critical for interaction with UL25 and incorporation of capsid into vesicles in the perinuclear space2018

    • Author(s)
      Kosuke Takeshima,Jun Arii,Yuhei Maruzuru,Naoto Koyanagi,Akihisa Kato, Yasushi Kawaguchi
    • Organizer
      第66回日本ウイルス学会学術集会
    • Data Source
      KAKENHI-PROJECT-18K15164
  • [Presentation] A HSV-2 specific phosphorylation event mediated by Us3 kinase is involved in viral pathogenicity in mice following vaginal infection2018

    • Author(s)
      Misato Shibazaki, Akihisa Kato, Naoto Koyanagi, Yuhei Maruzuru, Jun Arii, Yasushi Kawaguchi
    • Organizer
      43nd Annual International Herpesvirus Workshop
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15164
  • 1.  有井 潤
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 2.  丸鶴 雄平
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 8 results
  • 3.  川口 寧
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results

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