Tai Ikue 田井育江

Researcher Number	90749508
Other IDs
Affiliation (Current)	2025: 慶應義塾大学, 医学部(信濃町), 講師
Affiliation (based on the past Project Information) *help	2018 – 2025: 慶應義塾大学, 医学部(信濃町), 講師 2016 – 2017: 慶應義塾大学, 医学部(信濃町), 特別研究員(RPD) 2015: 慶應義塾大学, 医学部, 特別研究員(RPD)
Review Section/Research Field	Principal Investigator Basic Section 49010:Pathological biochemistry-related / Pathological medical chemistry / Cardiovascular medicine Except Principal Investigator Transformative Research Areas, Section (III)
Keywords	Principal Investigator 血管新生 / Folliculin / Tspan18 / FLCN / Prox1 / リンパ管 / Tetraspanin / shedding / VEGFR2 / Tetraspanin18 … More / angiogenesis / テトラスパニン / 血管形成 / 網膜血管 / リンパ弁 / 髄膜リンパ管 / prox1 / 弁構造 / リンパ管弁 / VEGFシグナル / Tspan / VEGFR2切断断片 / リン酸化VEGFR2 / 静脈内皮 / 血管内皮 / リンパ管内皮 / tetraspanin / リンパ管新生 / 血管 / VEGF signaling / tetraspanin18 / メタロプロテアーゼ / 血管内皮細胞 / VEGF受容体 … More Except Principal Investigator 恒常性 / 多細胞間クロストーク / 腸 / リンパ管 / 血管 / 間質性細胞 / 臓器連関 / 複雑系細胞クロストーク / 血管リンパ管系 / 大腸炎 / 肺線維症 / 間質と実質 / 間質リテラシー / 血管・リンパ管系 / 間葉系 / 神経系 / 免疫系 / 間質 Less

"FLCN-Prox1シグナリング"によるリンパ管弁の恒常性維持とその破綻Principal Investigator
- Principal Investigator
  
  田井育江
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Keio University
リンパ管機能の維持におけるがん抑制遺伝子Folliculinの役割Principal Investigator
- Principal Investigator
  
  田井育江
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Keio University
Establishment of interstitial literacy based on complex systems crosstalk
- Principal Investigator
  
  佐藤荘
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Tokyo Medical and Dental University
The study on interstitial multicellular crosstalk; Significance of blood and lymphatic vessels.
- Principal Investigator
  
  内藤尚道
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Kanazawa University
Role of Tspan18 in the intracellular trafficking of VEGF receptorPrincipal Investigator
- Principal Investigator
  
  Tai Ikue
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Keio University
Mechanistic elucidation of angiogenesis mediated by Tspan18Principal Investigator
- Principal Investigator
  
  Tai Ikue
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Keio University
Tetraspanins regulate the formation of mature blood vesselsPrincipal Investigator
- Principal Investigator
  
  Tai Ikue
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Keio University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Spatial heterogeneity of bone marrow endothelial cells unveils a distinct subtype in the epiphysis2023
- Author(s)
  Iga Takahito、Kobayashi Hiroshi、Kusumoto Dai、Sanosaka Tsukasa、Fujita Nobuyuki、Tai-Nagara Ikue、Ando Tomofumi、Takahashi Tomoko et.al
- Journal Title
  
  Nature Cell Biology
  
  Volume: 25 Issue: 10 Pages: 1415-1425
- DOI
  10.1038/s41556-023-01240-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23KJ1885, KAKENHI-PROJECT-22K06915, KAKENHI-PROJECT-21K08431, KAKENHI-PROJECT-22K19550, KAKENHI-PROJECT-19H03623, KAKENHI-PROJECT-21H02957, KAKENHI-PROJECT-21H03057, KAKENHI-PROJECT-23K21467, KAKENHI-PROJECT-23K27352
[Journal Article] Tumor-specific inter-endothelial adhesion mediated by FLRT2 facilitates cancer aggressiveness2022
- Author(s)
  Ando T, Tai-Nagara I, Sugiura Y, Kusumoto D, Okabayashi K, Kido Y, Sato Kohji, Saya H, Navankasattusas S, Li DY, Suematsu M, Kitagawa Y, Seiradake E, Yamagishi S, *Kubota Y.
- Journal Title
  
  J Clin Invest
  
  Volume: 132 Issue: 6 Pages: 153626-153626
- DOI
  10.1172/jci153626
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07389, KAKENHI-PROJECT-19K08549, KAKENHI-PROJECT-20K21499, KAKENHI-PROJECT-22K06915, KAKENHI-PROJECT-20H00518, KAKENHI-PROJECT-23K21369
[Journal Article] Trim41 is required to regulate chromosome axis protein dynamics and meiosis in male mice2022
- Author(s)
  Oura Seiya、Hino Toshiaki、Satoh Takashi、Noda Taichi、Koyano Takayuki、Isotani Ayako、Matsuyama Makoto、Akira Shizuo、Ishiguro Kei-ichiro、Ikawa Masahito
- Journal Title
  
  PLOS Genetics
  
  Volume: 18 Issue: 6 Pages: e1010241-e1010241
- DOI
  10.1371/journal.pgen.1010241
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-22H05060, KAKENHI-PLANNED-22H05061, KAKENHI-PROJECT-20H03172, KAKENHI-PLANNED-19H05750
[Journal Article] Coupling of angiogenesis and odontogenesis orchestrates tooth mineralization in mice2022
- Author(s)
  Matsubara T, Iga T, Sugiura Y, Kusumoto D, Sanosaka T, Tai-Nagara I, Takeda N, Fong GH, Ito K, Ema M, Okano H, Kohyama J, Suematsu M, *Kubota Y.
- Journal Title
  
  J Exp Med
  
  Volume: 219 Issue: 4
- DOI
  10.1084/jem.20211789
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07389, KAKENHI-PROJECT-19K08549, KAKENHI-PROJECT-19H03397, KAKENHI-PROJECT-22K06915, KAKENHI-PROJECT-19H03623
[Journal Article] Genetic Deletion of Vascular Endothelial Growth Factor Receptor 2 in Endothelial Cells Leads to Immediate Disruption of Tumor Vessels and Aggravation of Hypoxia.2021
- Author(s)
  Kido Y, Ando T, Iga T, Ema M, *Kubota Y, *Tai-Nagara I.
- Journal Title
  
  Am J Pathol.
  
  Volume: 9440 Issue: 2 Pages: 00511-3
- DOI
  10.1016/j.ajpath.2021.11.003
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07389, KAKENHI-PROJECT-19H03397, KAKENHI-PROJECT-22K06915
[Journal Article] Neuron-derived VEGF contributes to cortical and hippocampal development independently of VEGFR1/2-mediated neurotrophism.2020
- Author(s)
  Okabe K, Fukada H, Tai-Nagara I, Ando T, Honda T, Nakajima K, Takeda N, Fong GH, Ema M, Kubota Y.
- Journal Title
  
  Dev Biol.
  
  Volume: 459(2) Issue: 2 Pages: 65-71
- DOI
  10.1016/j.ydbio.2019.11.016
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07389, KAKENHI-PUBLICLY-18H05042, KAKENHI-PROJECT-19H03397, KAKENHI-PLANNED-16H06482
[Journal Article] TAK1 Prevents Endothelial Apoptosis and Maintains Vascular Integrity.2018
- Author(s)
  Naito H, Iba T, Wakabayashi T, Tai-Nagara I, Suehiro JI, Jia W, Eino D, Sakimoto S, Muramatsu F, Kidoya H, Sakurai H, Satoh T, Akira S, Kubota Y, Takakura N.
- Journal Title
  
  Dev Cell.
  
  Volume: 48 Issue: 2 Pages: 151-166
- DOI
  10.1016/j.devcel.2018.12.002
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20317, KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05042, KAKENHI-PROJECT-16H02470, KAKENHI-PROJECT-17K15625, KAKENHI-PROJECT-18K16956, KAKENHI-PROJECT-19K16742
[Journal Article] Placental labyrinth formation in mice requires endothelial FLRT2/UNC5B signaling2017
- Author(s)
  Tai-Nagara Ikue、Yoshikawa Yusuke、Numata Naoko、Ando Tomofumi、Okabe Keisuke、Sugiura Yuki、Ieda Masaki、Takakura Nobuyuki、Nakagawa Osamu、Zhou Bin、Okabayashi Koji、Suematsu Makoto、Kitagawa Yuko、Bastmeyer Martin、Sato Kohji、Klein R?diger、Navankasattusas Sutip、Li Dean Y.、Yamagishi Satoru、Kubota Yoshiaki
- Journal Title
  
  Development
  
  Volume: 144 Pages: 2392-2401
- DOI
  10.1242/dev.149757
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08512, KAKENHI-PROJECT-17K19678, KAKENHI-PROJECT-17K15625, KAKENHI-PROJECT-26293193, KAKENHI-PROJECT-16H02470, KAKENHI-PROJECT-15H04883, KAKENHI-PROJECT-16H06145, KAKENHI-PROJECT-15J40132, KAKENHI-PROJECT-15K15313
[Presentation] 血管とリンパ管の独立性を規定する分子機構とその破綻2022
- Author(s)
  田井育江
- Organizer
  比較免疫学会第33回学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K06915
[Presentation] 血管とリンパ管の独立性を規定する分子機構とその破綻2019
- Author(s)
  田井育江
- Organizer
  第124回日本解剖学会総会・全国学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17K15625
[Presentation] 血管とリンパ管の独立性を規定する分子機構とその破綻2019
- Author(s)
  田井育江
- Organizer
  第一回医学会連合リトリート
- Data Source
  KAKENHI-PROJECT-17K15625
[Presentation] Tetraspanins regulate the formation of mature blood vessels.2016
- Author(s)
  田井育江, 久保田義顕
- Organizer
  第24回日本血管生物医学会学術集会
- Place of Presentation
  長崎ブリックホール
- Year and Date
  2016-12-08
- Data Source
  KAKENHI-PROJECT-15K19397
[Presentation] Tspan18 contributes to the formation of the high-ordered vascular architecture in the retina2015
- Author(s)
  田井育江
- Organizer
  13th Japan-Korea Joint Symposium on Vascular Biology
- Place of Presentation
  MBC サムジュアートホール(韓国・釜山)
- Year and Date
  2015-10-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19397
[Presentation] Tspan18 contributes to the formation of the high-order architecture in retinal vascular development2015
- Author(s)
  田井育江
- Organizer
  第9回Aso International Meeting (AIM)
- Place of Presentation
  ホテルグリーンピア南阿蘇(熊本)
- Year and Date
  2015-05-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19397

1. 内藤尚道 (30570676)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 佐藤荘 (60619716)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 石亀晴道 (70729227)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 伊藤美菜子 (70793115)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 七野成之 (70822435)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 尾松芳樹 (80437277)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 増田隆博 (80615287)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 山岸覚

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 若林卓

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tai Ikue 田井 育江

Research Projects

Research Products

Co-Researchers

"FLCN-Prox1シグナリング"によるリンパ管弁の恒常性維持とその破綻Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

リンパ管機能の維持におけるがん抑制遺伝子Folliculinの役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of interstitial literacy based on complex systems crosstalk

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The study on interstitial multicellular crosstalk; Significance of blood and lymphatic vessels.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of Tspan18 in the intracellular trafficking of VEGF receptorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanistic elucidation of angiogenesis mediated by Tspan18Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Tetraspanins regulate the formation of mature blood vesselsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Spatial heterogeneity of bone marrow endothelial cells unveils a distinct subtype in the epiphysis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tumor-specific inter-endothelial adhesion mediated by FLRT2 facilitates cancer aggressiveness2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Trim41 is required to regulate chromosome axis protein dynamics and meiosis in male mice2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Coupling of angiogenesis and odontogenesis orchestrates tooth mineralization in mice2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genetic Deletion of Vascular Endothelial Growth Factor Receptor 2 in Endothelial Cells Leads to Immediate Disruption of Tumor Vessels and Aggravation of Hypoxia.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Neuron-derived VEGF contributes to cortical and hippocampal development independently of VEGFR1/2-mediated neurotrophism.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TAK1 Prevents Endothelial Apoptosis and Maintains Vascular Integrity.2018

Author(s)

Journal Title

DOI

Tai Ikue 田井育江