Tarashima Noriko 田良島典子

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TARASHIMA Noriko 田良島典子

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Researcher Number	90755183
Other IDs
Affiliation (Current)	2025: 徳島大学, 大学院医歯薬学研究部(薬学域), 准教授
Affiliation (based on the past Project Information) *help	2021 – 2025: 徳島大学, 大学院医歯薬学研究部(薬学域), 准教授 2019 – 2021: 徳島大学, 大学院医歯薬学研究部(薬学域), 講師 2018: 徳島大学, 大学院医歯薬学研究部(薬学域), 助教 2016 – 2017: 徳島大学, 大学院医歯薬学研究部(薬学系), 助教 2015: 徳島大学, 大学院医歯薬学研究部, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Drug development chemistry / Basic Section 47060:Clinical pharmacy-related Except Principal Investigator Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Medium-sized Section 47:Pharmaceutical sciences and related fields / Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related / Basic Section 47050:Environmental and natural pharmaceutical resources-related / Medium-sized Section 37:Biomolecular chemistry and related fields / Medium-sized Section 38:Agricultural chemistry and related fields / Basic Section 37030:Chemical biology-related
Keywords	Principal Investigator STING / がん免疫療法 / 環状ジヌクレオチド / 環状ジペプチド / プロドラッグ / mRNA / 人工核酸 / 環状ジヌクレオチド類 / 化学修飾核酸 / 核酸医薬 … More / 核酸創薬 / 自然免疫応答 / ケミカルプローブ / RNA干渉 / siRNA … More Except Principal Investigator 4'-チオ核酸 / ホスホフロリダート / 固相合成 / DNA合成 / siRNA / 代謝拮抗剤 / 抗ウイルス剤 / 合成セントラルドグマ / セントラルドグマ / 人工核酸 / 人工細胞 / 合成生物学 / 核酸化学 / 新型コロナウイルス / mRNAワクチン / 予防薬 / ヌクレオシド / 治療薬 / RNAウイルス感染症 / 機能性食品 / 4'-セレノRNA / 4'-チオRNA / マイクロRNA / RNAi医薬品 / 微弱電流 / 核酸ナノ構造体 / iRed / RNAi医薬 / 核酸創薬 Less

核酸医薬の毒性を回避するドラッグリポジショニング研究の新展開Principal Investigator
- Principal Investigator
  
  田良島典子
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  The University of Tokushima
Establishment of next-generation drug discovery platform for viral infections
- Principal Investigator
  
  南川典昭
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
  Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  The University of Tokushima
Development of a kilo-scale DNA chemical synthesis based on phosphofluoridate exchange reactions.
- Principal Investigator
  
  南川典昭
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  The University of Tokushima
mRNA医薬開発を加速する人工核酸技術の創出Principal Investigator
- Principal Investigator
  
  田良島典子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  The University of Tokushima
Treatment and prevention of RNA virus infections based on 4'-thionucleic acid technology
- Principal Investigator
  
  MINAKAWA Noriaki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  The University of Tokushima
Novel cell system developed by chemistry
- Principal Investigator
  
  MINAKAWA Noriaki
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 37:Biomolecular chemistry and related fields
- Research Institution
  The University of Tokushima
Development of microRNA to eat: Nucleic acid as a supplement food
- Principal Investigator
  
  MINAKAWA Noriaki
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  The University of Tokushima
Medicinal chemistry targeting STING for cancer immunotherapyPrincipal Investigator
- Principal Investigator
  
  TARASHIMA Noriko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  The University of Tokushima
Development of photoresponsive DNA nanostructure to accerelate iRed based nucleic acid medicine
- Principal Investigator
  
  MINAKAWA Noriaki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  The University of Tokushima
Medicinal chemistry on cyclic dinucleotides as immunotherapeutic agents.Principal Investigator
- Principal Investigator
  
  TARASHIMA Noriko
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokushima
Elucidation of interaction between siRNA and pattern recognition receptors toward systematic siRNA drug designPrincipal Investigator
- Principal Investigator
  
  TARASHIMA Noriko
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokushima

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Book

[Book] 核酸科学ハンドブック2020
- Author(s)
  南川典昭、田良島典子
- Total Pages
  576
- Publisher
  講談社
- ISBN
  9784065207864
- Data Source
  KAKENHI-PROJECT-18H02108
[Book] CSJ Current Review 生命機能に迫る分子化学、第16章化学修飾DNAを利用したRNAi創薬2018
- Author(s)
  田良島典子、南川典昭
- Total Pages
  191
- Publisher
  化学同人
- ISBN
  9784759813906
- Data Source
  KAKENHI-PROJECT-17K15481
[Book] Four-hydrogen-bonding base pairs in oligonucleotides: design, synthesis and properties, Synthesis of Therapeutic Oligonucleotides2018
- Author(s)
  Noriko Saito-Tarashima, Akira Matsuda, Noriaki Minakawa
- Total Pages
  284
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-18H02108
[Book] CSJ Current Review 生命機能に迫る分子化学、第16章化学修飾DNAを利用したRNAi創薬2018
- Author(s)
  田良島典子、南川典昭
- Total Pages
  191
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-18H02108
[Book] RNA bioisoster: Chemistry and properties of 4’-thioRNA and 4’-selenoRNA, Synthesis of Therapeutic Oligonucleotides2018
- Author(s)
  Noriaki Minakawa, Akira Matsuda, Noriko Saito-Tarashima
- Total Pages
  284
- Publisher
  Springer
- ISBN
  9789811319112
- Data Source
  KAKENHI-PROJECT-17K15481
[Book] RNA bioisoster: Chemistry and properties of 4’-thioRNA and 4’-selenoRNA,Synthesis of Therapeutic Oligonucleotides2018
- Author(s)
  Noriaki Minakawa, Akira Matsuda, Noriko Saito-Tarashima
- Total Pages
  284
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-18H02108
[Book] Four-hydrogen-bonding base pairs in oligonucleotides: design, synthesis and properties, Synthesis of Therapeutic Oligonucleotides2018
- Author(s)
  Noriko Saito-Tarashima, Akira Matsuda, Noriaki Minakawa
- Total Pages
  284
- Publisher
  Springer
- ISBN
  9789811319112
- Data Source
  KAKENHI-PROJECT-17K15481
[Book] Synthesis of Therapeutic Oligonucleotides, RNA bioisoster: Chemistry and properties of 4’-thioRNA and 4’-selenoRNA2017
- Author(s)
  Noriaki Minakawa, Akira Matsuda, Noriko Saito-Tarashima
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-15H06446
[Book] Synthesis of Therapeutic Oligonucleotides, Four-hydrogen-bonding base pairs in oligonucleotides: design, synthesis and properties2017
- Author(s)
  Noriko Saito-Tarashima, Akira Matsuda, Noriaki Minakawa
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-15H06446
[Book] 核酸医薬の創製と応用展開、第8章生物学的等価性を指向した化学修飾 DNA による核酸創薬研究2016
- Author(s)
  田良島典子、南川典昭
- Total Pages
  278
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-15H06446
[Journal Article] Chemistry of Cyclic Dinucleotides and Analogs2023
- Author(s)
  Saito‐Tarashima Noriko、Minakawa Noriaki
- Journal Title
  
  Handbook of Chemical Biology of Nucleic Acids
  
  Volume: 1 Pages: 1-30
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02606
[Journal Article] Synthesis of oligonucleotides containing 5′-homo-4′-selenouridine derivative and its increased resistance against nuclease2023
- Author(s)
  Yu Jinha、Kim Ji Won、Chandra Girish、Saito-Tarashima Noriko、Nogi Yuhei、Ota Masashi、Minakawa Noriaki、Jeong Lak Shin
- Journal Title
  
  Bioorganic Medicinal Chemistry Letters
  
  Volume: 83 Pages: 129172-129172
- DOI
  10.1016/j.bmcl.2023.129172
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02606
[Journal Article] Synthesis of 4′‐Thiomodified c‐di‐AMP Analogs2023
- Author(s)
  Saito‐Tarashima Noriko、Kagotani Yuma、Inoue Syuya、Kinoshita Mao、Minakawa Noriaki
- Journal Title
  
  Current Protocols
  
  Volume: 3 Issue: 9
- DOI
  10.1002/cpz1.892
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02606
[Journal Article] Synthesis and Behavior of DNA Oligomers Containing the Ambiguous Z-Nucleobase 5-Aminoimidazole-4-carboxamide2023
- Author(s)
  Nogi Yuhei、Saito-Tarashima Noriko、Karanjit Sangita、Minakawa Noriaki
- Journal Title
  
  Molecules
  
  Volume: 28 Issue: 7 Pages: 3265-3265
- DOI
  10.3390/molecules28073265
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02606
[Journal Article] Cas9-mediated DNA cleavage guided by enzymatically prepared 4′-thio-modified RNA2022
- Author(s)
  Saito-Tarashima Noriko、Ueno Mana、Murai Akiho、Matsuo Ayako、Minakawa Noriaki
- Journal Title
  
  Organic Biomolecular Chemistry
  
  Volume: 20 Issue: 26 Pages: 5245-5248
- DOI
  10.1039/d2ob00742h
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02606, KAKENHI-PROJECT-21K19052
[Journal Article] Synthesis and properties of fully-modified 4′-selenoRNA, an endonuclease-resistant RNA analog2022
- Author(s)
  Ota Masashi、Takahashi Hiromi、Nogi Yuhei、Kagotani Yuma、Saito-Tarashima Noriko、Kondo Jiro、Minakawa Noriaki
- Journal Title
  
  Bioorganic Medicinal Chemistry
  
  Volume: 76 Pages: 117093-117093
- DOI
  10.1016/j.bmc.2022.117093
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02606
[Journal Article] Rewriting the Central Dogma with Synthetic Genetic Polymers2022
- Author(s)
  Saito-Tarashima Noriko、Murai Akiho、Minakawa Noriaki
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 70 Issue: 5 Pages: 310-315
- DOI
  10.1248/cpb.c21-00960
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2022-05-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02606, KAKENHI-PROJECT-21K19052
[Journal Article] The Golgi-resident protein ACBD3 concentrates STING at ER-Golgi contact sites to drive export from the ER2022
- Author(s)
  Motani Kou、Saito-Tarashima Noriko、Nishino Kohei、Yamauchi Shunya、Minakawa Noriaki、Kosako Hidetaka
- Journal Title
  
  Cell Reports
  
  Volume: 41 Issue: 12 Pages: 111868-111868
- DOI
  10.1016/j.celrep.2022.111868
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06628, KAKENHI-PROJECT-20K07340, KAKENHI-PROJECT-21H02606, KAKENHI-PROJECT-21K19052
[Journal Article] Synthesis and Anti-dengue Virus Activity of 5-Ethynylimidazole-4-carboxamide (EICA) Nucleotide Prodrugs2022
- Author(s)
  Nakamura Motoki、Uemura Kentaro、Saito-Tarashima Noriko、Sato Akihiko、Orba Yasuko、Sawa Hirofumi、Matsuda Akira、Maenaka Katsumi、Minakawa Noriaki
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 70 Issue: 3 Pages: 220-225
- DOI
  10.1248/cpb.c21-01038
- NAID
  130008165548
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2022-03-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02606, KAKENHI-PROJECT-21K19052
[Journal Article] フラノース環酸素原子をイオウ、セレン原子に置換した核酸誘導体の有機合成化学2020
- Author(s)
  太田雅士、田良島典子、南川典昭
- Journal Title
  
  有機合成化学協会誌
  
  Volume: －
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16316
[Journal Article] A Unique Gene-Silencing Approach, Using an Intelligent RNA Expression Device (iRed), Results in Minimal Immune Stimulation When Given by Local Intrapleural Injection in Malignant Pleural Mesothelioma2020
- Author(s)
  Ando Hidenori、Saito-Tarashima Noriko、Lila Amr S. Abu、Kinjo Nozomi、Shimizu Taro、Ishima Yu、Minakawa Noriaki、Ishida Tatsuhiro
- Journal Title
  
  Molecules
  
  Volume: 25 Issue: 7 Pages: 1725-1725
- DOI
  10.3390/molecules25071725
- NAID
  120006995468
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02108
[Journal Article] Gene Expression of 4′-Thioguanine DNA via 4′-Thiocytosine RNA2020
- Author(s)
  Tarashima Noriko S.、Matsuo Ayako、Minakawa Noriaki
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 142 Issue: 41 Pages: 17255-17259
- DOI
  10.1021/jacs.0c07145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02108
[Journal Article] フラノース環酸素原子をイオウ、セレン原子に置換した核酸誘導体の有機合成化学2020
- Author(s)
  太田雅士、田良島典子、南川典昭
- Journal Title
  
  有機合成化学協会誌
  
  Volume: －
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K22287
[Journal Article] A unique gene-silencing approach, using an intelligent RNA expression device (iRed), results in minimal immune stimulation when given by local intrapleural injection in malignant pleural mesothelioma2020
- Author(s)
  Hidenori Ando, Noriko Saito-Tarashima, Amr selim, Nozomi Kinjo, Taro Shimizu, Yu Ishima, Noriaki Minakawa, Tatsuhiro Ishida
- Journal Title
  
  Molecules
  
  Volume: －
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16316
[Journal Article] Synthesis and properties of oligonucleotides containing a 2,6-diamino-3-deazapurine:furanopyrimidine base pair2020
- Author(s)
  Matsumoto Koki、Saito-Tarashima Noriko、Wada Tomoya、Yonaha Orie、Minakawa Noriaki
- Journal Title
  
  Nucleosides, Nucleotides & Nucleic Acids
  
  Volume: － Issue: 10 Pages: 1-18
- DOI
  10.1080/15257770.2019.1694687
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16316
[Journal Article] Synthesis of nucleoside units possessing photoreactive diazirine groups on the major and minor2019
- Author(s)
  Tomoya Wada, Noriko Saito-Tarashima, Mayu Yamada, Yasuko Okamoto, Noriaki Minakawa
- Journal Title
  
  Tetrahesron Lett.
  
  Volume: 60 Issue: 23 Pages: 1530-1533
- DOI
  10.1016/j.tetlet.2019.05.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02108, KAKENHI-PROJECT-19K16316
[Journal Article] Synthesis and biological evaluation of novel imidazole nucleosides as potential anti-dengue virus agents2019
- Author(s)
  Okano Yuki、Saito-Tarashima Noriko、Kurosawa Madoka、Iwabu Ai、Ota Masashi、Watanabe Tadashi、Kato Fumihiro、Hishiki Takayuki、Fujimuro Masahiro、Minakawa Noriaki
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 27 Issue: 11 Pages: 2181-2186
- DOI
  10.1016/j.bmc.2019.04.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08870, KAKENHI-PROJECT-18K06642, KAKENHI-PROJECT-18H02108, KAKENHI-PROJECT-19K16316
[Journal Article] 四本の水素結合を介してペアを形成するImNN:NaOO塩基対の複製2019
- Author(s)
  田良島典子
- Journal Title
  
  日本核酸化学会誌
  
  Volume: 3 Pages: 17-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16316
[Journal Article] Ribavirin-related compounds exert in vitro inhibitory effects toward rabies virus2018
- Author(s)
  Anindita Paulina D.、Sasaki Michihito、Okada Kazuma、Ito Naoto、Sugiyama Makoto、Saito-Tarashima Noriko、Minakawa Noriaki、Shuto Satoshi、Otsuguro Satoko、Ichikawa Satoshi、Matsuda Akira、Maenaka Katsumi、Orba Yasuko、Sawa Hirofumi
- Journal Title
  
  Antiviral Research
  
  Volume: 154 Pages: 1-9
- DOI
  10.1016/j.antiviral.2018.03.011
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-16H06429, KAKENHI-PLANNED-16H06431, KAKENHI-PROJECT-15K07716, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-PROJECT-18H02108, KAKENHI-PROJECT-17K15481
[Journal Article] Unnatural Base Pairs for Synthetic Biology2018
- Author(s)
  Saito-Tarashima Noriko、Minakawa Noriaki
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 66 Issue: 2 Pages: 132-138
- DOI
  10.1248/cpb.c17-00685
- NAID
  130006328054
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02108, KAKENHI-PROJECT-17K15481
[Journal Article] Synthesis of 4’-selenoribonucleosides, the building blocks of 4’-selenoRNA, using a hypervalent iodine.2017
- Author(s)
  Noriko Saito-Tarashima, Ota Masashi, Noriaki Minakawa
- Journal Title
  
  Curr. Protoc. Nucleic Acid Chem.
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H06446
[Journal Article] Groove modification of siRNA duplexes to elucidate siRNA-protein interactions using 7-bromo-7-deazaadenosine and 3-bromo- 3-deazaadenosine as chemical probes2016
- Author(s)
  Noriko Saito-Tarashima, Hirotaka Kira, Tomoya Wada, Kazuya Miki, Shiho Ide, Naoshi Yamazaki, Akira Matsuda, Noriaki Minakawa
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 14 Issue: 47 Pages: 11096-11105
- DOI
  10.1039/c6ob01866a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04656, KAKENHI-PROJECT-15H06446
[Journal Article] Practical synthesis of 40-selenopurine nucleosides by combining chlorinated purines and ‘armed’ 4-selenosugar2016
- Author(s)
  Kazuki Ishii, Noriko Saito-Tarashima , Masashi Ota, Seigi Yamamoto, Yasuko Okamoto, Yoshiyuki Tanaka, Noriaki Minakawa
- Journal Title
  
  Tetrahedron
  
  Volume: 72 Issue: 41 Pages: 6589-6594
- DOI
  10.1016/j.tet.2016.08.071
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04656, KAKENHI-PROJECT-15H06446, KAKENHI-PROJECT-15K13734
[Journal Article] The novel functional nucleic acid iRed effectively regulates target genes following cytoplasmic delivery by faint electric treatment2016
- Author(s)
  Mahadi Hasan, Noriko Tarashima, Koki Fujikawa, Takashi Ohgita, Susumu Hama, Tamotsu Tanaka, Hiroyuki Saito, Noriaki Minakawa, Kentaro Kogure
- Journal Title
  
  Science and Technology of Advanced Materials
  
  Volume: 17 Issue: 1 Pages: 554-562
- DOI
  10.1080/14686996.2016.1221726
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-WRAPUP-16H01692, KAKENHI-PROJECT-15H04656, KAKENHI-PROJECT-15H06446, KAKENHI-PROJECT-25293006
[Journal Article] Gene silencing using 4’-thioDNA as an artificial template to syunthesize short hairpin RNA without inducing a detectable innate immune response.2016
- Author(s)
  Noriko Tarashima, Hidenori Ando,Takamitsu Kojima,Nozomi Kinjo,Yosuke Hashimoto,Kazuhiro Furukawa,Tatsuhiro Ishida, Noriaki Minakawa
- Journal Title
  
  Mol.Ther.Nucl.Acids
  
  Volume: 5 Pages: e274-e274
- DOI
  10.1038/mtna.2015.48
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04656, KAKENHI-PROJECT-15H06446
[Journal Article] Faithful PCR Amplification of an Unnatural Base-Pair Analogue with Four Hydrogen Bond2015
- Author(s)
  Noriko Tarashima,Yasuo Komatsu,Kazuhiro Furukawa,and Noriaki Minakawa*
- Journal Title
  
  Chem. Eur.J.
  
  Volume: 21 Issue: 30 Pages: 10688-10695
- DOI
  10.1002/chem.201583062
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04656, KAKENHI-PROJECT-15H06446
[Journal Article] Synthesis of DNA fragments containing 2’-deoxy-4’-selenonucleoside units using DNA polymerases: comparison of dNTPs with O, S and Se at the 4’-position in replication2015
- Author(s)
  Noriko Tarashima, Tatsuya Sumitomo, Hidenori Ando, Kazuhiro Furukawa, Tatsuhiro Ishida and Noriaki Minakawa*
- Journal Title
  
  Org.Biomol.Chem
  
  Volume: 13 Issue: 25 Pages: 6949-6952
- DOI
  10.1039/c5ob00941c
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04656, KAKENHI-PROJECT-15H06446, KAKENHI-PROJECT-26630432
[Presentation] 抗SARS-CoV-2活性を指標とした4’-チオ修飾siRNAの最適化2024
- Author(s)
  野木悠平、田良島典子、駒貴明、月本準、野間口雅子、南川典昭
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-21H02606
[Presentation] Disruption of the cell membrane by G-quadruplex formation on antibody2024
- Author(s)
  Murai A., Saito-Tarashima N., Oba M., Kawanishi K., Tsukimoto J., Minakawa N.
- Organizer
  Supra FIBER International Summit for Nucleic Acids (S-FISNA)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02606
[Presentation] SARS-CoV-2活性を発揮する3-デアザグアノシンの発見と作用メカニズム解明2024
- Author(s)
  吉田圭吾、日野谷直人、小笠萌香、田良島典子、駒貴明、野間口雅子、南川典昭
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-21H02606
[Presentation] 3-Deazaguanosine exhibits anti-SARS-CoV-2 activity and blocks the development of COVID-19 pneumonis in hamsters.2024
- Author(s)
  Minakawa N., Saito-Tarashima N., Koma T., Hinotani N., Yoshida K., Ogasa M., Murai A., Inoue S., Kondo T., Doi N., Tsuneyama K., Nomaguchi M.
- Organizer
  Supra FIBER International Summit for Nucleic Acids (S-FISNA)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02606
[Presentation] Development of the 4’-thiomodified siRNAs against SARS-CoV-22023
- Author(s)
  Nogi Y., Saito-Tarashima N., Koma T., Nomaguchi M., Minakawa N.
- Organizer
  14th AFMC International Medicinal Chemistry Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02606
[Presentation] 4’-チオ核酸修飾siRNAの開発(2)2023
- Author(s)
  尾崎里奈、野木悠平、田良島典子、駒貴明、月本準、野間口雅子、南川典昭
- Organizer
  第62回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-21H02606
[Presentation] 糖部4’位を硫黄原子で置換した環状ジヌクレオチド類 (CDNs) は優れたSTINGアゴニスト活性を発揮する2023
- Author(s)
  近藤明希、木下真緒、田良島典子、南川典昭
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K19052
[Presentation] 環状ジヌクレオチドによるヒト脳微小血管内皮細胞STING経路の活性化2023
- Author(s)
  橋本彩伽、稲垣舞、田良島典子、山内駿弥、南川典昭、立川正憲
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K19052
[Presentation] 2’-Fluoro-4’-thiopurine nucleosidesの合成研究2023
- Author(s)
  坂上祐貴、田良島典子、南川典昭
- Organizer
  創薬懇話会2023
- Data Source
  KAKENHI-PROJECT-21H02606
[Presentation] 4’-チオレムデシビルの合成研究2023
- Author(s)
  三原菜那、田良島典子、南川典昭
- Organizer
  第62回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-21H02606
[Presentation] 4’-チオ核酸修飾siRNAの開発(1)2023
- Author(s)
  野木悠平、田良島典子、駒貴明、野間口雅子、南川典昭
- Organizer
  第62回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-21H02606
[Presentation] DNA二重らせん中におけるZ塩基の塩基対形成能2023
- Author(s)
  野木悠平、田良島典子、南川典昭
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K19052
[Presentation] 抗SARS-CoV-2の活性獲得を目指した3-デアザプリンヌクレオシド類の合成2023
- Author(s)
  小笠萌香、日野谷直人、田良島典子、駒貴明、野間口雅子、南川典昭
- Organizer
  第62回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-21H02606
[Presentation] SARS-CoV-2を標的とした4’-チオ修飾siRNAの創製2023
- Author(s)
  野木悠平、田良島典子、駒貴明、野間口雅子、南川典昭
- Organizer
  日本核酸医薬学会第8回年会
- Data Source
  KAKENHI-PROJECT-21H02606
[Presentation] 抗SARS-CoV-2活性を有する5-hydroxymethyltubercidin (HMTU)の合成2023
- Author(s)
  河口愛奈、山田真由、田良島典子、南川典昭
- Organizer
  第62回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-21H02606
[Presentation] Chemical challenge to the central dogma with 4'-thionucleotides2022
- Author(s)
  Noriko Saito Tarashima, Noriaki Minakawa
- Organizer
  15th International Symposium on Nanomedicine　(ISNM2022)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02606
[Presentation] ZTPの化学合成とRNAポリメラーゼに対する基質認識能の評価2022
- Author(s)
  村井あきほ、田良島典子、南川典昭
- Organizer
  第61回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-21K19052
[Presentation] Synthesis and physical/enzymatic behaviors of the DNA oligomer possessing an ambiguous base, 5-aminoimidazole-4-carboxamide2022
- Author(s)
  Yuhei Nogi, Noriaki Saito-Tarashima, Noriaki Minakawa.
- Organizer
  The 49th International Symposium on Nucleic Acids Chemistry / The 6th Annual Meeting of Japanese Society of Nucleic Acids Chemistry (ISNAC 2022)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02606
[Presentation] Synthesis of the membrane-permeable 2’,3’-cGAMP type CDN analog.2022
- Author(s)
  Kashiwabara Y., Yamauchi S., Saito-Tarashima N., Minakawa N.
- Organizer
  15h International Symposium on Nanomedicine (ISNM2022)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19052
[Presentation] 4’-SelenoRNAから構成される環状ジヌクレオチドの合成研究2022
- Author(s)
  籠谷侑真、田良島典子、南川典昭
- Organizer
  第61回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-21K19052
[Presentation] 膜透過性型cyclic dinucleotide analogの創製2022
- Author(s)
  山内駿弥、田良島典子、茂谷康、小迫英尊、南川典昭
- Organizer
  日本核酸医薬学会第7回年会
- Data Source
  KAKENHI-PROJECT-21K19052
[Presentation] 2’-置換-N4-ヒドロキシシチジン (NHC) 誘導体の合成及び新型コロナウイルス (SARS-CoV-2) に対する活性評価2022
- Author(s)
  上田直也、田良島典子、南川典昭
- Organizer
  第61回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-21H02606
[Presentation] Synthesis and enzymatic recognition of ZTP.2022
- Author(s)
  Murai A., Saito-Tarashima N., Minakawa N.
- Organizer
  15h International Symposium on Nanomedicine (ISNM2022)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19052
[Presentation] 糖部フラノース環4'位に硫黄原子を有するcyclic dinucleotide (CDN) analogsの創薬化学研究2022
- Author(s)
  近藤明希、木下真緒、田良島典子、南川典昭
- Organizer
  第61回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-21H02606
[Presentation] 5-Ethynylimidazole-4-carboxamide (EICA)ヌクレオチドプロドラッグの合成と抗デングウイルス活性2022
- Author(s)
  日野谷直人、中村元紀、田良島典子、大場靖子、澤洋文、松田彰、前仲勝美、南川典昭
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21H02606
[Presentation] 4'-チオBNA/LNAヌクレオシドの合成研究2022
- Author(s)
  白木優也、前田璃音、宮澤俊輝、田良島典子、吉村祐一、南川典昭
- Organizer
  第61回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-21H02606
[Presentation] 環状ジヌクレオチド類のメディシナルケミストリー2022
- Author(s)
  田良島典子
- Organizer
  第146回日本薬学会中国四国支部例会
- Data Source
  KAKENHI-PROJECT-21K19052
[Presentation] 2’-置換-N4-ヒドロキシシチジン (NHC) 誘導体の合成および新型コロナウイルス (SARS-CoV-2) に対する活性評価2022
- Author(s)
  上田直也、田良島典子、南川典昭
- Organizer
  第61回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-21K19052
[Presentation] 光分解性保護基を有するAntibody-Oligonucleotide Conjugateの創製2022
- Author(s)
  川西香菜子、田良島典子、南川典昭
- Organizer
  第61回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-21K19052
[Presentation] Chemical challenge to the central dogma with 4’-thionucleotides.2022
- Author(s)
  Saito-Tarashima N., Minakawa N.
- Organizer
  15h International Symposium on Nanomedicine (ISNM2022)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19052
[Presentation] ZTPの合成と各種ポリメラーゼに対する基質認識能の評価2022
- Author(s)
  村井あきほ、田良島典子、南川典昭
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21H02606
[Presentation] 環状ジヌクレオチド糖部4’位への硫黄原子の導入はSTINGアゴニスト活性を増強させる2022
- Author(s)
  田良島典子、木下真緒、近藤明希、南川典昭
- Organizer
  日本化学会第102春季年会
- Data Source
  KAKENHI-PROJECT-21H02606
[Presentation] 4’-チオBNA/LNAヌクレオシドの合成研究2022
- Author(s)
  白木優也、前田璃音、宮澤俊輝、田良島典子、吉村祐一、南川典昭
- Organizer
  第61回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-21K19052
[Presentation] 2’-Deoxy-2’-F-4’-thionucleosideの合成研究2022
- Author(s)
  坂上祐貴、田良島典子、南川典昭
- Organizer
  第61回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-21K19052
[Presentation] Synthesis and physical/enzymatic behaviors of the DNA oligomer possessing an ambiguous base, 5-aminoimidazole-4-carboxamide.2022
- Author(s)
  Nogi Y., Saito-Tarashima N., Minakawa N.
- Organizer
  The 49th International Symposium on Nucleic Acids Chemistry / The 6th Annual Meeting of Japan Society of Nucleic Acids Chemistry (ISNAC2022)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19052
[Presentation] 2'-Deoxy-2'-F-4'-thionucleosideの合成研究2022
- Author(s)
  坂上祐貴、田良島典子、南川典昭
- Organizer
  第61回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-21H02606
[Presentation] Synthesis and evaluation of the DNA oligomer possessing 5-aminoimidazole-4-carboxamide (Z)-base.2022
- Author(s)
  Nogi Y., Saito-Tarashima N., Minakawa N.
- Organizer
  15h International Symposium on Nanomedicine (ISNM2022)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19052
[Presentation] Synthesis of cyclic dinucleotide analog enhanced membrane permeability.2022
- Author(s)
  Yamauchi S., Saito-Tarashima N., Motani K., Kosako H., Minakawa N.
- Organizer
  15h International Symposium on Nanomedicine (ISNM2022)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19052
[Presentation] 糖部フラノース環4’位に硫黄原子を有するcyclic dinucleotide (CDN) analogsの創薬化学研究2022
- Author(s)
  近藤明希、木下真緒、田良島典子、南川典昭
- Organizer
  第61回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-21K19052
[Presentation] Synthesis of cyclic dinucleotide analog enhanced membrane permeability2022
- Author(s)
  Shunya Yamauchi, Noriko Saito Tarashima, Kou Motani, Hidetaka Kosako, Noriaki Minakawa
- Organizer
  15th International Symposium on Nanomedicine　(ISNM2022)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02606
[Presentation] 4-チオフラノースを構成糖に持つ人工核酸による遺伝子発現2021
- Author(s)
  田良島典子、松尾礼子、南川典昭
- Organizer
  日本化学会第１０１春季年会
- Data Source
  KAKENHI-PROJECT-18H02108
[Presentation] c-di-4’-thioAMPの合成と自然免疫誘導能の評価2020
- Author(s)
  木下真緒、田良島典子、南川典昭
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18H02108
[Presentation] siRNA-タンパク質間相互作用解析のための標的捕捉型ケミカルプローブ導入siRNAの創製と性質評価2020
- Author(s)
  和田知也、山田真由、田良島典子、南川典昭
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K16316
[Presentation] 抗デングウイルス活性の増強を目指したイミダゾールヌクレオシド誘導体の合成研究2020
- Author(s)
  河野滉也、田良島典子、南川典昭
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K16316
[Presentation] イミダゾール型環状ジヌクレオチド誘導体の合成研究2020
- Author(s)
  田良島典子、熊埜御堂優介、南川典昭
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K16316
[Presentation] c-di-4’-thioAMPの合成と自然免疫誘導能の評価2020
- Author(s)
  木下真緒、田良島典子、南川典昭
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K16316
[Presentation] ヌクレオシドケミカルプローブ①: siRNA-タンパク質間相互作用様式の解明に向けた光反応性ケミカルプローブの開発研究2019
- Author(s)
  和田知也、山田真由、田良島典子、南川典昭
- Organizer
  日本核酸医薬学会第5回年会
- Data Source
  KAKENHI-PROJECT-19K16316
[Presentation] Synthesis and biological potential of modified cyclic dinucleotides2019
- Author(s)
  Noriko Saito-Tarashima, Noriaki Minakawa
- Organizer
  Asian International Symposium The 99th CSJ Annual Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15481
[Presentation] ゲノム編集に利用可能な4’-チオガイドRNAの開発2019
- Author(s)
  上野真奈、田良島典子、南川典昭
- Organizer
  第58回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-19K16316
[Presentation] 4種のヌクレオチドがセレノ修飾された完全修飾型4’-セレノRNAの合成と性質解析2019
- Author(s)
  太田雅士、田良島典子、高橋宏美、近藤次郎、南川典昭
- Organizer
  日本核酸医薬学会第5回年会
- Data Source
  KAKENHI-PROJECT-19K16316
[Presentation] ゲノム編集に利用可能な4’-チオガイドRNAの開発2019
- Author(s)
  上野真奈、田良島典子、南川典昭
- Organizer
  第58回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-18H02108
[Presentation] Synthesis of cyclic-di-ZMP2019
- Author(s)
  Yusuke Kumanomido, Noriko Saito-Tarashima, Noriaki Minakawa
- Organizer
  The 46th International Symposium on Nucleic Acids Chemistry / The 3rd Annual Meeting of Japan Society of Nucleic Acids Chemistry (ISNAC 2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16316
[Presentation] ホスホロチオエート型c-di-AMPプロドラッグの合成研究2019
- Author(s)
  寺内勝之、田良島典子、南川典昭
- Organizer
  第58回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-19K16316
[Presentation] RNA干渉創薬の実現へ向けたケミカルアプローチ2019
- Author(s)
  田良島典子
- Organizer
  第58回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-19K16316
[Presentation] イミダゾール型環状ジヌクレオチドc-di-ZMPの合成2019
- Author(s)
  熊埜御堂優介、田良島典子、南川典昭
- Organizer
  第58回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-19K16316
[Presentation] 4’-チオ核酸により構成されるセントラルドグマの構築2019
- Author(s)
  田良島典子、松尾礼子、南川典昭
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18H02108
[Presentation] ヌクレオシドケミカルプローブ②: 光反応性ケミカルプローブ7dia-deAの改良合成法の開発研究2019
- Author(s)
  山田真由、和田知也、田良島典子、南川典昭
- Organizer
  日本核酸医薬学会第5回年会
- Data Source
  KAKENHI-PROJECT-19K16316
[Presentation] Synthesis and biological evaluation of cyclic dinucleotide analogs2019
- Author(s)
  Noriko Saito-Tarashima, Yusuke Kumanomido, Mao Kinoshita, Kazuhito Shiraishi, Kazuhiro Furukawa, Noriaki Minakawa
- Organizer
  Commemorative International Symposium of the Japan Society of Nucleic Acids Chemistry (CISNAC 2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16316
[Presentation] 4’-位に硫黄原子を有する環状ジヌクレオチドの合成と自然免疫誘導能の評価2019
- Author(s)
  木下真緒、田良島典子、熊埜御堂優介、南川典昭
- Organizer
  日本核酸医薬学会第5回年会
- Data Source
  KAKENHI-PROJECT-18H02108
[Presentation] 抗デングウイルス活性を有するイミダゾールヌクレオシド類の開発研究2019
- Author(s)
  中村元紀、田良島典子、岡野裕貴、黒沢まどか、岩部愛、渡辺匡史、加藤文博、日柴喜隆行、藤室雅弘、南川典昭
- Organizer
  日本核酸医薬学会第5回年会
- Data Source
  KAKENHI-PROJECT-19K16316
[Presentation] 4’-チオ核酸により構成されるセントラルドグマの構築2019
- Author(s)
  田良島典子、松尾礼子、南川典昭
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17K15481
[Presentation] 4種のヌクレオチドがセレノ修飾された完全修飾型4’-セレノRNAの合成と性質解析2019
- Author(s)
  太田雅士、田良島典子、高橋宏美、近藤次郎、南川典昭
- Organizer
  日本核酸医薬学会第5回年会
- Data Source
  KAKENHI-PROJECT-18H02108
[Presentation] 環状ジヌクレオチドアナログc-di-ZMPの合成2019
- Author(s)
  熊埜御堂優介、田良島典子、南川典昭
- Organizer
  日本核酸医薬学会第5回年会
- Data Source
  KAKENHI-PROJECT-19K16316
[Presentation] 4’-位に硫黄原子を有する環状ジヌクレオチドの合成と自然免疫誘導能の評価2019
- Author(s)
  木下真緒、田良島典子、熊埜御堂優介、南川典昭
- Organizer
  日本核酸医薬学会第5回年会
- Data Source
  KAKENHI-PROJECT-19K16316
[Presentation] RNA結合タンパク質捕捉のためのヌクレオシド型ケミカルプローブの開発研究2018
- Author(s)
  山田真由、和田知也、田良島典子、南川典昭
- Organizer
  日本核酸医薬学会第57回中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-17K15481
[Presentation] mRNAの構造変化を誘起するヌクレオチド誘導体の創製 -c-di-4’-thioAMPの合成とリボスイッチに対する結合親和性評価-2018
- Author(s)
  田良島典子、井形陽佑、白石和人、古川和寛、南川典昭
- Organizer
  日本核酸医薬学会第4回年会
- Data Source
  KAKENHI-PROJECT-17K15481
[Presentation] Creation of a puDDD: pyAAA H-bonding base pair in DNA oligonucleotide2018
- Author(s)
  Koki Matsumoto, Noriko Saito-Tarashima, Noriaki Minakawa
- Organizer
  The 45th International Symposium on Nucleic Acids Chemistry (ISNAC 2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02108
[Presentation] 抗デングウイルス化合物の探索2018
- Author(s)
  黒澤まどか、日紫喜隆行、加藤文博、岡野裕貴、田良島典子、南川典昭、渡部匡史、藤室雅弘
- Organizer
  第66回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-17K15481
[Presentation] Development and Evaluation of Photoresponsive DNA Prism with Nucleic Acid Medicine2018
- Author(s)
  Seigi Yamamoto, Noriko Saito-Tarashima, Naoshi Yamazaki, Tatsuya Fukuta, Kentaro Kogure, Noriaki Minakawa
- Organizer
  The 45th International Symposium on Nucleic Acids Chemistry (ISNAC 2018）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02108
[Presentation] 亜リン酸の段階的活性化に基づく環状ジヌクレオチド類合成法の開発2018
- Author(s)
  熊埜御堂優介、田良島典子、井形陽佑、山口直記、南川典昭
- Organizer
  第57回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-17K15481
[Presentation] 抗デングウイルス活性を有するイミダゾールヌクレオシド類の開発研究2018
- Author(s)
  中村元紀、岡野祐貴、黒沢まどか、田良島典子、日柴喜隆行、加藤文博、渡辺匡史、藤室雅弘、南川典昭
- Organizer
  第57回日本薬学会・薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-17K15481
[Presentation] Creation of a puDDD: pyAAA H-bonding base pair in DNA oligonucleotide2018
- Author(s)
  Koki Matsumoto, Noriko Saito-Tarashima, Noriaki Minakawa
- Organizer
  The 45th International Symposium on Nucleic Acids Chemistry (ISNAC 2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15481
[Presentation] mRNAの構造変化を誘起する中分子化合物の創製 -c-di-4’-thioAMPの合成とリボスイッチに対する結合親和性評価-2018
- Author(s)
  田良島典子、井形陽佑、白石和人、古川和寛、南川典昭
- Organizer
  日本ケミカルバイオロジー学会第13回年会
- Data Source
  KAKENHI-PROJECT-17K15481
[Presentation] Development and Evaluation of Photoresponsive DNA Prism with Nucleic Acid Medicine2018
- Author(s)
  Seigi Yamamoto, Noriko Saito-Tarashima, Naoshi Yamazaki, Tatsuya Fukuta, Kentaro Kogure, Noriaki Minakawa
- Organizer
  The 45th International Symposium on Nucleic Acids Chemistry (ISNAC 2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15481
[Presentation] 核酸分子の簡便精製を可能とする ‘Catch & Release’ 法の開発2017
- Author(s)
  井形陽佑、相良和幸、田良島典子、南川典昭
- Organizer
  日本薬学会第 137年会
- Place of Presentation
  仙台国際センター (宮城県仙台市)
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15H06446
[Presentation] siRNA-パターン認識受容体の相互作用解析のためのケミカルアプローチ2017
- Author(s)
  和田知也、田良島典子、吉良太孝、南川典昭
- Organizer
  日本薬学会第 137年会
- Place of Presentation
  仙台国際センター (宮城県仙台市)
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15H06446
[Presentation] 4’-セレノリボヌクレオシド類の効率的合成とRNAオリゴマー導入の試み2017
- Author(s)
  太田雅士、田良島典子、石井和貴、南川典昭
- Organizer
  日本薬学会第 137年会
- Place of Presentation
  仙台国際センター (宮城県仙台市)
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15H06446
[Presentation] Chemical and enzymatic synthesis of 4’-seleno oligonucleotides2017
- Author(s)
  Noriko Saito-Tarashima, Koya Hayashi, Tatsuya Sumitomo, Noriaki Minakawa
- Organizer
  The 43th International Symposium on Nucleic Acids Chemistry (ISNAC 2016)
- Place of Presentation
  熊本大学工学部百周年記念館 (熊本県熊本市)
- Year and Date
  2017-03-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H06446
[Presentation] RNA-タンパク質間相互作用解明のためのケミカルツールの創製2016
- Author(s)
  和田知也、田良島典子、吉良太孝、南川典昭
- Organizer
  第55回日本薬学会・日本薬剤師会・日本病院薬剤師会・中国四国支部学術大会
- Place of Presentation
  就実大学 (岡山県岡山市)
- Year and Date
  2016-11-05
- Data Source
  KAKENHI-PROJECT-15H06446
[Presentation] iRedを利用した持続的microRNA補充法の開発2016
- Author(s)
  上田　夏瑞, 田良島　典子, 三木　和也, 山村　桃子, 山﨑　尚志, 南川　典昭
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県、横浜市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15H06446
[Presentation] ‘キャッチ&リリース’ 法を用いたオリゴヌクレオチドの簡便精製法の開発2016
- Author(s)
  井形陽佑、相良和幸、田良島典子、南川典昭
- Organizer
  日本核酸医薬学会第2回年会
- Place of Presentation
  東京理科大学葛飾キャンパス図書館大ホール (東京都葛飾区)
- Year and Date
  2016-11-15
- Data Source
  KAKENHI-PROJECT-15H06446
[Presentation] Generation of RNA medicine using 4’-thio DNA2016
- Author(s)
  Noriko Tarashima, Tatsuhiro Ishida, Noriaki Minakawa
- Organizer
  The 8th Takeda Science Foundation Symposium on PharmaSciences
- Place of Presentation
  武田薬品工業研修所（大阪府、吹田市）
- Year and Date
  2016-01-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H06446
[Presentation] 新規遺伝子発現デバイスiRedの開発と完全化学合成に向けた検討2016
- Author(s)
  高橋　知樹, 田良島　典子, 御牧　夕希子, 南川　典昭
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県、横浜市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15H06446
[Presentation] RNA-タンパク質間の動的な相互作用解析のためのケミカルアプローチ-真に医薬応用可能な化学修飾siRNAの理論的設計法の確立へ向けて-2016
- Author(s)
  田良島典子、和田知也、吉良太孝、南川典昭
- Organizer
  第34回メディシナルケミストリーシンポジウム
- Place of Presentation
  つくば国際会議場 (茨城県つくば市)
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15H06446
[Presentation] Gene silencing via RNA interference (RNAi) machinery using 4'-thioDNA as an artificial template2015
- Author(s)
  Norioko Tarashima, Nozomi Kinjyo, Takamitsu Kojima, Hidenori Ando, Tatsuhiro Ishida, Noriaki Minakawa
- Organizer
  The 42nd International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  あいめっせホール（兵庫県、姫路市）
- Year and Date
  2015-09-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H06446
[Presentation] 人工塩基対の酵素認識に基づくダンベル型遺伝子発現デバイスの創製2015
- Author(s)
  田良島　典子, 南川　典昭
- Organizer
  日本核酸医薬学会第1回年会
- Place of Presentation
  京都テルサ（京都府、京都市）
- Year and Date
  2015-11-30
- Data Source
  KAKENHI-PROJECT-15H06446
[Presentation] Development of a Minimally-Sized DNA Vector for Gene Silencing using an Unnatural　 Base Pair Analog Having　Four Hydrogen Bonds2015
- Author(s)
  Noriko Tarashima, Noriaki Minakawa
- Organizer
  10th AFMC International Medicinal Chemistry Symposium
- Place of Presentation
  International Convention Center (ICC) JEJU（Jeju, Korea）
- Year and Date
  2015-10-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H06446
[Presentation] Targeted gene silencing by introduction of intelligent RNA expression device (iRed)2015
- Author(s)
  Nozomi Kinjyo, Hidenori Ando, Noriko Tarashima, Noriaki Minakawa, Tatsuhiro Ishida
- Organizer
  Liposome Advances 2015
- Place of Presentation
  UCL School of Pharmacy（London, UK）
- Year and Date
  2015-12-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H06446

1. MINAKAWA Noriaki (40209820)

# of Collaborated Projects: 6 results

# of Collaborated Products: 66 results
2. 小暮健太朗 (70262540)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
3. 駒貴明 (00803496)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
4. 野間口雅子 (80452647)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
5. 山本清義 (80783521)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. HISHIKI Takayuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 石田竜弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
8. 澤洋文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 小迫英尊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tarashima Noriko 田良島 典子

TARASHIMA Noriko 田良島 典子

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Co-Researchers

核酸医薬の毒性を回避するドラッグリポジショニング研究の新展開Principal Investigator

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Establishment of next-generation drug discovery platform for viral infections

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Development of a kilo-scale DNA chemical synthesis based on phosphofluoridate exchange reactions.

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mRNA医薬開発を加速する人工核酸技術の創出Principal Investigator

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Treatment and prevention of RNA virus infections based on 4'-thionucleic acid technology

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Novel cell system developed by chemistry

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Development of microRNA to eat: Nucleic acid as a supplement food

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Medicinal chemistry targeting STING for cancer immunotherapyPrincipal Investigator

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Development of photoresponsive DNA nanostructure to accerelate iRed based nucleic acid medicine

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Medicinal chemistry on cyclic dinucleotides as immunotherapeutic agents.Principal Investigator

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Elucidation of interaction between siRNA and pattern recognition receptors toward systematic siRNA drug designPrincipal Investigator

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[Book] 核酸科学ハンドブック2020

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[Book] CSJ Current Review 生命機能に迫る分子化学、第16章 化学修飾DNAを利用したRNAi創薬2018

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Total Pages

Tarashima Noriko 田良島典子

TARASHIMA Noriko 田良島典子

[Book] CSJ Current Review 生命機能に迫る分子化学、第16章化学修飾DNAを利用したRNAi創薬2018

[Book] CSJ Current Review 生命機能に迫る分子化学、第16章化学修飾DNAを利用したRNAi創薬2018

[Book] 核酸医薬の創製と応用展開、第8章生物学的等価性を指向した化学修飾 DNA による核酸創薬研究2016