Okato Atsushi 岡東篤

… Alternative Names

岡東篤オカトウアツシ

OKATO ATSUSHI 岡東篤

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Researcher Number	90756719
Other IDs	https://orcid.org/0000-0002-4207-9744
Affiliation (Current)	2025: 国立研究開発法人量子科学技術研究開発機構, QST病院治療診断部, 医長
Affiliation (based on the past Project Information) *help	2025: 国立研究開発法人量子科学技術研究開発機構, QST病院治療診断部, 医長 2021 – 2023: 帝京大学, 医学部, 助教 2017 – 2018: 千葉大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / 0901:Oncology and related fields / Urology Except Principal Investigator Basic Section 52040:Radiological sciences-related / Urology
Keywords	Principal Investigator FGFR3 / FGFR3変異 / 腫瘍免疫環境 / 免疫チェックポイント阻害薬 / FGFR阻害薬 / 遺伝子改変モデルマウス / 膀胱癌 / FGFR3遺伝子変異 / 腎細胞癌 / 治療抵抗性腎癌 / マイクロRNA … More Except Principal Investigator … More 前立腺癌 / ホルモン治療 / 中リスク前立腺癌 / グリソンスコア / 重粒子線治療 / 癌遺伝子 / 癌抑制遺伝子 / 去勢抵抗性前立腺癌 / 細胞外マトリックス / マイクロRNA Less

中間リスク前立腺癌に対するホルモン療法併用炭素イオン線治療の至適プロトコルの探求
- Principal Investigator
  
  小林加奈
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  National Institutes for Quantum Science and Technology
Elucidation of the tumor microenvironment of FGFR3-mutant bladder cancer using genetically engineered murine modelsPrincipal Investigator
- Principal Investigator
  
  岡東篤
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Teikyo University
FGFR3遺伝子改変モデル膀胱癌における腫瘍微小環境の解明と新規治療への応用Principal Investigator
- Principal Investigator
  
  岡東篤
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0901:Oncology and related fields
- Research Institution
  Teikyo University
Identifying molecular pathogenesis of advanced renal cell carcinoma based on microRNA expressionPrincipal Investigator
- Principal Investigator
  
  Okato Atsushi
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Urology
- Research Institution
  Chiba University
Elucidation of extracellular matrix molecular pathway regulated by metastasis-suppressing microRNAs in prostate cancer.
- Principal Investigator
  
  KATO MAYUKO
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Urology
- Research Institution
  Chiba University

All 2024 2018 2017 2016

All Journal Article Presentation

[Journal Article] FGFR inhibition augments anti?PD-1 efficacy in murine FGFR3-mutant bladder cancer by abrogating immunosuppression2024
- Author(s)
  Okato Atsushi、Utsumi Takanobu、Kim William Y.
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 134 Issue: 2
- DOI
  10.1172/jci169241
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K14628, KAKENHI-PROJECT-21K20814
[Journal Article] Molecular pathogenesis of renal cell carcinoma: class FormattedString { value: Impact of the anti-tumor miR-29 family on gene regulation }2018
- Author(s)
  Yamada, Y. Sugawara, S. Arai, T. Kojima, S. Kato, M. Okato, A. Yamazaki, K. Naya, Y. Ichikawa, T. Seki, N.
- Journal Title
  
  Int J Urol
  
  Volume: 25 Issue: 11 Pages: 953
- DOI
  10.1111/iju.13783
- URL
  https://localhost/en/publications/7a2668e6-2185-41ef-9dc3-1c1fe85d2edd
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11160, KAKENHI-PROJECT-18K16685, KAKENHI-PROJECT-16H05462, KAKENHI-PROJECT-17K16778
[Journal Article] Impact of novel oncogenic pathways regulated by antitumor miR-451a in renal cell carcinoma2018
- Author(s)
  Yamada Yasutaka、Arai Takayuki、Sugawara Sho、Okato Atsushi、Kato Mayuko、Kojima Satoko、Yamazaki Kazuto、Naya Yukio、Ichikawa Tomohiko、Seki Naohiko
- Journal Title
  
  Cancer Sci
  
  Volume: 109 Issue: 4 Pages: 1239
- DOI
  10.1111/cas.13526
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05462, KAKENHI-PROJECT-17K11160, KAKENHI-PROJECT-18K16685, KAKENHI-PROJECT-17K16778
[Journal Article] Molecular pathogenesis of interstitial cystitis based on microRNA expression signature: MiR-320 family-regulated molecular pathways and targets2018
- Author(s)
  Arai T, Fuse M, Goto Y, Kaga K, Kurozumi A, Yamada Y, Sugawara S, Okato A, Ichikawa T, Yamanishi T, Seki N.
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 63 Issue: 5 Pages: 543
- DOI
  10.1038/s10038-018-0419-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16779, KAKENHI-PROJECT-16H05462, KAKENHI-PROJECT-17K16778
[Journal Article] Dual strands of the miR-223 duplex (miR-223-5p and miR-223-3p) inhibit cancer cell aggressiveness: targeted genes are involved in bladder cancer pathogenesis2018
- Author(s)
  Sugawara Sho、Yamada Yasutaka、Arai Takayuki、Okato Atsushi、Idichi Tetsuya、Kato Mayuko、Koshizuka Keiichi、Ichikawa Tomohiko、Seki Naohiko
- Journal Title
  
  J Hum Genet
  
  Volume: 印刷中 Issue: 5 Pages: 657-668
- DOI
  10.1038/s10038-018-0437-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05462, KAKENHI-PROJECT-17K16778
[Journal Article] Regulation of NCAPG by miR-99a-3p (passenger strand) inhibits cancer cell aggressiveness and is involved in CRPC2018
- Author(s)
  Arai, T. Okato, A. Yamada, Y. Sugawara, S. Kurozumi, A. Kojima, S. Yamazaki, K. Naya, Y. Ichikawa, T. Seki, N.
- Journal Title
  
  Cancer Med
  
  Volume: 7 Issue: 5 Pages: 1988
- DOI
  10.1002/cam4.1455
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11160, KAKENHI-PROJECT-16H05462, KAKENHI-PROJECT-17K16778
[Journal Article] Regulation of antitumor miR-144-5p targets oncogenes: Direct regulation of syndecan-3 and its clinical significance2018
- Author(s)
  Yamada, Y. Arai, T. Kojima, S. Sugawara, S. Kato, M. Okato, A. Yamazaki, K. Naya, Y. Ichikawa, T. Seki, N.
- Journal Title
  
  Cancer Sci
  
  Volume: 109 Issue: 9 Pages: 2919
- DOI
  10.1111/cas.13722
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11160, KAKENHI-PROJECT-18K16685, KAKENHI-PROJECT-18K16723, KAKENHI-PROJECT-16H05462, KAKENHI-PROJECT-17K16778
[Journal Article] Regulation of HMGB3 by antitumor miR-205-5p inhibits cancer cell aggressiveness and is involved in prostate cancer pathogenesis2017
- Author(s)
  Yamada Yasutaka、Nishikawa Rika、Kato Mayuko、Okato Atsushi、Arai Takayuki、Kojima Satoko、Yamazaki Kazuto、Naya Yukio、Ichikawa Tomohiko、Seki Naohiko
- Journal Title
  
  J Hum Genet
  
  Volume: 63 Issue: 2 Pages: 195
- DOI
  10.1038/s10038-017-0371-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05462, KAKENHI-PROJECT-16K20125, KAKENHI-PROJECT-17K11160
[Journal Article] Regulation of metastasis-promoting LOXL2 gene expression by antitumor microRNAs in prostate cancer.2017
- Author(s)
  Kato M, Kurozumi A, Goto Y, Matsushita R, Okato A, Nishikawa R, Fukumoto I, Koshizuka K, Ichikawa T, Seki N.
- Journal Title
  
  Journal of Human genetics
  
  Volume: 62 Pages: 123-132
- NAID
  40021036352
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K20125
[Journal Article] Dual strands of pre-miR-150 (miR-150-5p and miR-150-3p) act as antitumor miRNAs targeting SPOCK1 in naïve and castration-resistant prostate cancer2017
- Author(s)
  Okato Atsushi、Arai Takayuki、Kojima Satoko、Koshizuka Keiichi、Osako Yusaku、Idichi Tetsuya、Kurozumi Akira、Goto Yusuke、Kato Mayuko、Naya Yukio、Ichikawa Tomohiko、Seki Naohiko
- Journal Title
  
  International Journal of Oncology
  
  Volume: 51 Issue: 1 Pages: 245
- DOI
  10.3892/ijo.2017.4008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11160, KAKENHI-PROJECT-16H05462, KAKENHI-PROJECT-16K20125
[Journal Article] Regulation of spindle and kinetochore-associated protein 1 by antitumor miR-10a-5p in renal cell carcinoma2017
- Author(s)
  Arai Takayuki、Okato Atsushi、Kojima Satoko、Idichi Tetsuya、Koshizuka Keiichi、Kurozumi Akira、Kato Mayuko、Yamazaki Kazuto、Ishida Yasuo、Naya Yukio、Ichikawa Tomohiko、Seki Naohiko
- Journal Title
  
  Cancer Science
  
  Volume: 108 Issue: 10 Pages: 2088
- DOI
  10.1111/cas.13331
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11160, KAKENHI-PROJECT-17K16778, KAKENHI-PROJECT-16H05462
[Journal Article] Antitumor miR-150-5p and miR-150-3p inhibit cancer cell aggressiveness by targeting SPOCK1 in head and neck squamous cell carcinoma.2017
- Author(s)
  Koshizuka, K., T. Hanazawa, N. Kikkawa, K. Katada, A. Okato, T. Arai, T. Idichi, Y. Osako, Y. Okamoto and N. Seki
- Journal Title
  
  Auris Nasus Larynx
  
  Volume: - Issue: 4 Pages: 854-865
- DOI
  10.1016/j.anl.2017.11.019
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16893, KAKENHI-PROJECT-17K11375, KAKENHI-PROJECT-18K09338, KAKENHI-PROJECT-17K16778
[Journal Article] Impact of novel miR-145-3p regulatory networks on survival in patients with castration-resistant prostate cancer2017
- Author(s)
  Goto Yusuke、Kurozumi Akira、Arai Takayuki、Nohata Nijiro、Kojima Satoko、Okato Atsushi、Kato Mayuko、Yamazaki Kazuto、Ishida Yasuo、Naya Yukio、Ichikawa Tomohiko、Seki Naohiko
- Journal Title
  
  British Journal of Cancer
  
  Volume: 117 Issue: 3 Pages: 409
- DOI
  10.1038/bjc.2017.191
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11160, KAKENHI-PROJECT-16H05462, KAKENHI-PROJECT-16K20125
[Journal Article] Dual strands of Pre-miR-149 inhibit cancer cell migration and invasion through targeting FOXM1 in renal cell carcinoma2017
- Author(s)
  Okato Atsushi、Arai Takayuki、Yamada Yasutaka、Sugawara Sho、Koshizuka Keiichi、Fujimura Lisa、Kurozumi Akira、Kato Mayuko、Kojima Satoko、Naya Yukio、Ichikawa Tomohiko、Seki Naohiko
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 18 Issue: 9 Pages: 1969-1969
- DOI
  10.3390/ijms18091969
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11160, KAKENHI-PROJECT-17K16778, KAKENHI-PROJECT-16H05462
[Journal Article] Regulation of E3 ubiquitin ligase-1 (WWP1) by microRNA-452 inhibits cancer cell migration and invasion in prostate cancer.2016
- Author(s)
  Goto Y, Kojima S, Kurozumi A, Kato M, Okato A, Matsushita R, Ichikawa T, Seki N.
- Journal Title
  
  British journal of cancer
  
  Volume: 114 Pages: 1135-44
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K20125
[Journal Article] Direct regulation of LAMP1 by tumor-suppressive microRNA-320a in prostate cancer2016
- Author(s)
  Okato A, Goto Y, Kurozumi A, Kato M, Kojima S, Matsushita R, Yonemori M, Miyamoto K, Ichikawa T, Seki N.
- Journal Title
  
  International journal of oncology
  
  Volume: 49 Pages: 111-22
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K20125
[Presentation] 腎細胞癌・マイクロRNA発現プロファイルに基づく、機能性RNAネットワークの探索2018
- Author(s)
  岡東　篤
- Organizer
  第106回日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-17K16778
[Presentation] Dual-strand tumor-suppressor microRNA-145 (miR-145-5p and miR-145-3p) are involved in castration-resistant prostate cancer pathogenesis2017
- Author(s)
  Mayuko Kato, Akira Kurozumi, Yusuke Goto, Nijiro Nohata, Takayuki Arai, Atsushi Okato, Keiichi Koshizuka, Satoko Kojima, Tomohiko Ichikawa, Naohiko Seki.
- Organizer
  American Association for Cancer Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20125
[Presentation] Tumor-suppressive microRNAs (miR-26a/b, miR-29a/b/c and miR-218) concertedly regulate metastasis-promoting LOXL2 in prostate cancer2017
- Author(s)
  Mayuko Kato, Akira Kurozumi, Yusuke Goto, Ryosuke Matsushita, Ichiro Fukumoto, Atsushi Okato, Rika Nishikawa, Shinichi Sakamoto, Tomohiko Ichikawa, Naohiko Seki
- Organizer
  American Association for Cancer Research Annual meeting 2016
- Place of Presentation
  Ernest N. Morial Convention Center New Orleans, Louisiana, USA
- Year and Date
  2017-04-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20125
[Presentation] The microRNA expression signature of patients with renal cell carcinoma : tumor-suppressive miR-149-5p targeting FOXM12017
- Author(s)
  Okato Atsushi
- Organizer
  2017 AUA Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16778

1. KATO MAYUKO (80733857)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
2. ICHIKAWA TOMOHIKO (20241953)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
3. SEKI NAOHIKO (50345013)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
4. KOJIMA SATOKO (10345019)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. ARAI TAKAYUKI (40793055)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. KOSHIZUKA KEIICHI (00791609)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. YAMADA YASUTAKA (30814595)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SUGAWARA SYO (70815290)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 小林加奈 (70433282)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 富居一範 (20431306)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 三浦航星 (20795736)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 石川仁 (70344918)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Okato Atsushi 岡東 篤

岡東 篤 オカトウ アツシ

OKATO ATSUSHI 岡東 篤

Research Projects

Research Products

Co-Researchers

中間リスク前立腺癌に対するホルモン療法併用炭素イオン線治療の至適プロトコルの探求

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the tumor microenvironment of FGFR3-mutant bladder cancer using genetically engineered murine modelsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

FGFR3遺伝子改変モデル膀胱癌における腫瘍微小環境の解明と新規治療への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identifying molecular pathogenesis of advanced renal cell carcinoma based on microRNA expressionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of extracellular matrix molecular pathway regulated by metastasis-suppressing microRNAs in prostate cancer.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] FGFR inhibition augments anti?PD-1 efficacy in murine FGFR3-mutant bladder cancer by abrogating immunosuppression2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Molecular pathogenesis of renal cell carcinoma: class FormattedString { value: Impact of the anti-tumor miR-29 family on gene regulation }2018

Author(s)

Journal Title

DOI

URL

Language

Data Source

[Journal Article] Impact of novel oncogenic pathways regulated by antitumor miR-451a in renal cell carcinoma2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Molecular pathogenesis of interstitial cystitis based on microRNA expression signature: MiR-320 family-regulated molecular pathways and targets2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dual strands of the miR-223 duplex (miR-223-5p and miR-223-3p) inhibit cancer cell aggressiveness: targeted genes are involved in bladder cancer pathogenesis2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regulation of NCAPG by miR-99a-3p (passenger strand) inhibits cancer cell aggressiveness and is involved in CRPC2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regulation of antitumor miR-144-5p targets oncogenes: Direct regulation of syndecan-3 and its clinical significance2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regulation of HMGB3 by antitumor miR-205-5p inhibits cancer cell aggressiveness and is involved in prostate cancer pathogenesis2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regulation of metastasis-promoting LOXL2 gene expression by antitumor microRNAs in prostate cancer.2017

Author(s)

Okato Atsushi 岡東篤

岡東篤オカトウアツシ

OKATO ATSUSHI 岡東篤