tsuchiya hikaru 土屋光

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TSUCHIYA Hikaru 土屋光

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Researcher Number	90760132
Other IDs
Affiliation (Current)	2025: 順天堂大学, 医学部, 准教授 2025: 公益財団法人東京都医学総合研究所, 基礎医科学研究分野, 研究員
Affiliation (based on the past Project Information) *help	2024: 順天堂大学, 医学部, 准教授 2020 – 2023: 公益財団法人東京都医学総合研究所, 基礎医科学研究分野, 主任研究員 2019 – 2020: 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 主任研究員 2015 – 2018: 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 研究員
Review Section/Research Field	Principal Investigator Basic Section 43030:Functional biochemistry-related / Transformative Research Areas, Section (III) / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Functional biochemistry Except Principal Investigator Broad Section G / Biological pharmacy
Keywords	Principal Investigator タンパク質分解 / ユビキチン / 蛋白質分解 / 液－液相分離 / 相分離 / プロテアソーム / ユビキチンリガーゼ Except Principal Investigator タンパク質分解 / プロテアソーム / ユビキチン … More / プロテアソーム病 / 質量分析 / 蛋白質 / シグナル伝達 / タンパク質 / 翻訳後修飾 / タンパク質分解誘導剤 / PROTAC / アポトーシス / 標的タンパク質分解 Less

Functional Analysis of Atypical Ubiquitin Chains in MammalsPrincipal Investigator
- Principal Investigator
  
  土屋光
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Juntendo University
Integrated understanding of proteasomal degradation and the ubiquitin code
- Principal Investigator
  
  佐伯泰
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section G
- Research Institution
  The University of Tokyo
メゾ複雑体ユビキチン液滴が司るタンパク質分解Principal Investigator
- Principal Investigator
  
  土屋光
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
)Regulation of protein degradation by proteasome-interacting ubiquitin ligasesPrincipal Investigator
- Principal Investigator
  
  TSUCHIYA Hikaru
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Elucidation of the proteasome activity by shuttle factorsPrincipal Investigator
- Principal Investigator
  
  TSUCHIYA Hikaru
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Elucidating the role of branched ubiquitin code
- Principal Investigator
  
  Ohtake Fumiaki
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hoshi University
  Tokyo Metropolitan Institute of Medical Science
A method for determining ubiquitin chain length in cellsPrincipal Investigator
- Principal Investigator
  
  TSUCHIYA Hikaru
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Functional biochemistry
- Research Institution
  Tokyo Metropolitan Institute of Medical Science

All 2024 2023 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Book

[Book] 実験医学別冊『決定版質量分析活用スタンダード』2023
- Author(s)
  佐伯泰、土屋光、遠藤彬則、冨田拓哉
- Total Pages
  11
- Publisher
  羊土社
- ISBN
  9784758122641
- Data Source
  KAKENHI-PROJECT-23H05479
[Journal Article] USP8 prevents aberrant NF-kappaB and Nrf2 activation by counteracting ubiquitin signals from endosomes.2024
- Author(s)
  Endo A, Fukushima T, Takahashi C, Tsuchiya H, Ohtake F, Ono S, Ly T, Yoshida Y, Tanaka K, Saeki Y, Komada M.
- Journal Title
  
  Journal of Cell Biology
  
  Volume: 223(3) Issue: 3 Pages: 1-1
- DOI
  10.1083/jcb.202306013
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06039, KAKENHI-ORGANIZER-23H04917, KAKENHI-PLANNED-23H04921, KAKENHI-PROJECT-23H05479, KAKENHI-PROJECT-22H00419, KAKENHI-PROJECT-23K23571
[Journal Article] MIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cFLIPL2021
- Author(s)
  Nakabayashi Osamu、Takahashi Hirotaka、Moriwaki Kenta、Komazawa-Sakon Sachiko、Ohtake Fumiaki、Murai Shin、Tsuchiya Yuichi、Koyahara Yuki、Saeki Yasushi、Yoshida Yukiko、Yamazaki Soh、Tokunaga Fuminori、Sawasaki Tatsuya、Nakano Hiroyasu
- Journal Title
  
  Communications Biology
  
  Volume: 4 Issue: 1 Pages: 80-80
- DOI
  10.1038/s42003-020-01603-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07399, KAKENHI-PROJECT-19K07516, KAKENHI-PROJECT-20K05238, KAKENHI-PROJECT-20K06611, KAKENHI-PROJECT-20K11589, KAKENHI-PLANNED-16H06575, KAKENHI-PLANNED-16H06579, KAKENHI-PUBLICLY-19H05292, KAKENHI-PROJECT-19H02926, KAKENHI-PROJECT-19H03218, KAKENHI-PROJECT-20H03475, KAKENHI-PROJECT-20K09231, KAKENHI-PROJECT-19K22541, KAKENHI-PLANNED-18H05498, KAKENHI-PROJECT-17H03986, KAKENHI-PROJECT-18H02619, KAKENHI-ORGANIZER-18H05497, KAKENHI-PROJECT-21H02688, KAKENHI-PROJECT-16H06276
[Journal Article] Stress- and ubiquitylation-dependent phase separation of the proteasome2020
- Author(s)
  Yasuda Sayaka、Tsuchiya Hikaru、Kaiho Ai、Guo Qiang、Ikeuchi Ken、Endo Akinori、Arai Naoko、Ohtake Fumiaki、Murata Shigeo、Inada Toshifumi、Baumeister Wolfgang、Fernandez-Busnadiego Ruben、Tanaka Keiji、Saeki Yasushi
- Journal Title
  
  Nature
  
  Volume: 578 Issue: 7794 Pages: 296-300
- DOI
  10.1038/s41586-020-1982-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05498, KAKENHI-PLANNED-18H05500, KAKENHI-PUBLICLY-19H05281, KAKENHI-PROJECT-18H03993, KAKENHI-PROJECT-18H04022, KAKENHI-PROJECT-18K14913, KAKENHI-PROJECT-26000014, KAKENHI-PROJECT-17H03986, KAKENHI-PROJECT-19H00997
[Journal Article] Detection of ubiquitination activity and identification of ubiquitinated substrates using TR-TUBE2019
- Author(s)
  Yoshida, Y., Saeki, Y., Tsuchiya, H., and Tanaka, K.
- Journal Title
  
  Methods Enzymol
  
  Volume: 618 Pages: 135-147
- DOI
  10.1016/bs.mie.2018.12.032
- ISBN
  9780128163597
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K14913, KAKENHI-ORGANIZER-18H05497, KAKENHI-PROJECT-18H03993, KAKENHI-PROJECT-16K07705, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-19H02926, KAKENHI-PROJECT-26000014
[Journal Article] Structural insights into ubiquitin recognition and Ufd1 interaction of Npl42019
- Author(s)
  Sato Yusuke、Tsuchiya Hikaru、Yamagata Atsushi、Okatsu Kei、Tanaka Keiji、Saeki Yasushi、Fukai Shuya
- Journal Title
  
  Nature Communications
  
  Volume: 10 Issue: 1 Pages: 5708-5708
- DOI
  10.1038/s41467-019-13697-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05498, KAKENHI-PLANNED-18H05501, KAKENHI-PROJECT-18H03993, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-19H03162, KAKENHI-PROJECT-18K14913, KAKENHI-PROJECT-26000014
[Journal Article] Methods to measure ubiquitin chain length and linkage.2019
- Author(s)
  Ohtake, F., Tsuchiya, H., Tanaka, K., and Saeki, Y.
- Journal Title
  
  Methods Enzymol
  
  Volume: 618 Pages: 105-133
- DOI
  10.1016/bs.mie.2018.12.019
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K14913, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05498, KAKENHI-PROJECT-18H03993, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-17H03986, KAKENHI-PROJECT-16K14702
[Journal Article] K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains.2018
- Author(s)
  Ohtake, F., Tsuchiya, H., Saeki, Y., and Tanaka, K
- Journal Title
  
  PNAS
  
  Volume: 115 Issue: 7 Pages: 1401-1408
- DOI
  10.1073/pnas.1716673115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K14702, KAKENHI-PROJECT-26293018, KAKENHI-PROJECT-17H03986, KAKENHI-PROJECT-26000014
[Journal Article] Ub-ProT reveals global length and composition of protein ubiquitylation in cells2018
- Author(s)
  Tsuchiya, H., Burana, D., Ohtake, F., Arai, N., Kaiho, A., Komada, M., Tanaka,K., and Saeki, Y.
- Journal Title
  
  Nature Commun
  
  Volume: 9 Issue: 1 Pages: 524-524
- DOI
  10.1038/s41467-018-02869-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K14702, KAKENHI-PROJECT-26293018, KAKENHI-PUBLICLY-17H05681, KAKENHI-PROJECT-17H03986, KAKENHI-PROJECT-26000014
[Journal Article] In Vivo Ubiquitin Linkage-type Analysis Reveals that the Cdc48-Rad23/Dsk2 Axis Contributes to K48-linked Chain Specificity of the Proteasome2017
- Author(s)
  Hikaru Tsuchiya, Fumiaki Ohtake, Naoko Arai, Ai Kaiho, Sayaka Yasuda, Keiji Tanaka, and Yasushi Saeki
- Journal Title
  
  Molecular Cell
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H06882
[Journal Article] The complexity of ubiquitin architecture.2016
- Author(s)
  Ohtake, F., and Tsuchiya, H
- Journal Title
  
  J Biochem
  
  Volume: 161 Pages: 125-133
- DOI
  10.1093/jb/mvw088
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H06882, KAKENHI-PLANNED-24112004, KAKENHI-PROJECT-16K14702
[Presentation] ubiquitylation dependent phase separation of the proteasome2023
- Author(s)
  土屋光、佐伯泰
- Organizer
  第64回日本神経病理学会総会学術研究会、第66回日本神経化学会大会合同学会
- Invited
- Data Source
  KAKENHI-PUBLICLY-22H05553
[Presentation] The ubiquitin ligase UBE3A negatively regulates the 26S proteasome by ubiquitylation of PSMD42021
- Author(s)
  Tsuchiya Hikaru, Kei Okatsu, Fukai Shuya, Yasushi Saeki
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20H03214
[Presentation] プロテアソーム液滴基質のプロテオーム解析2021
- Author(s)
  土屋光、佐伯泰
- Organizer
  日本プロテオーム学会2021年大会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03214
[Presentation] Stress and ubiquitylation-dependent phase separation of the proteasome2019
- Author(s)
  Tsuchiya, H
- Organizer
  EMBO Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14913
[Presentation] ケモテクノロジーと質量分析計を活用したユビキチンコードの解読2019
- Author(s)
  佐伯泰、遠藤彬則、土屋光、大竹史明
- Organizer
  日本ケミカルバイオロジー学会第14回年会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03986
[Presentation] ストレス依存的なプロテアソーム液-液相分離2019
- Author(s)
  土屋光
- Organizer
  第4回 LLPS研究会
- Data Source
  KAKENHI-PROJECT-18K14913
[Presentation] ユビキチン鎖長決定法の開発2018
- Author(s)
  土屋光、新井直子、海保愛、田中啓二、佐伯泰
- Organizer
  第91回　日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K14913
[Presentation] Ubiquitin chain selectivity of ubiquitin-binding proteins in yeast2016
- Author(s)
  Hikaru Tsuchiya
- Organizer
  7th PROTEASOME and AUTOPHAGY WORKSHOP
- Place of Presentation
  Clermont-Ferrand, France
- Year and Date
  2016-04-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H06882
[Presentation] プロテアソーム依存的タンパク質分解経路におけるユビキチン鎖選択制の解析2015
- Author(s)
  土屋光、吉原英人、新井直子、海保愛、田中啓二、佐伯泰
- Organizer
  第38回日本分子生物学会第88回　日本生化学会合同大会
- Place of Presentation
  神戸ポートアイランド (兵庫県神戸市)
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15H06882

1. Ohtake Fumiaki (60447373)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. 佐伯泰 (80462779)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. 森脇健太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 福嶋俊明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 深井周也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 村田茂穂

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

tsuchiya hikaru 土屋 光

TSUCHIYA Hikaru 土屋 光

Research Projects

Research Products

Co-Researchers

Functional Analysis of Atypical Ubiquitin Chains in MammalsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Integrated understanding of proteasomal degradation and the ubiquitin code

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

メゾ複雑体ユビキチン液滴が司るタンパク質分解Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

)Regulation of protein degradation by proteasome-interacting ubiquitin ligasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the proteasome activity by shuttle factorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidating the role of branched ubiquitin code

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A method for determining ubiquitin chain length in cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 実験医学別冊『決定版 質量分析活用スタンダード』2023

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] USP8 prevents aberrant NF-kappaB and Nrf2 activation by counteracting ubiquitin signals from endosomes.2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cFLIPL2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Stress- and ubiquitylation-dependent phase separation of the proteasome2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Detection of ubiquitination activity and identification of ubiquitinated substrates using TR-TUBE2019

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Structural insights into ubiquitin recognition and Ufd1 interaction of Npl42019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Methods to measure ubiquitin chain length and linkage.2019

tsuchiya hikaru 土屋光

TSUCHIYA Hikaru 土屋光

[Book] 実験医学別冊『決定版質量分析活用スタンダード』2023