LIAO JIYUAN 廖紀元

… Alternative Names

Liao Jiyuan 廖紀元

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Researcher Number	90781857
Affiliation (Current)	2026: 東京大学, 医科学研究所, 特任研究員
Affiliation (based on the past Project Information) *help	2024 – 2025: 東京大学, 医科学研究所, 特任研究員 2020 – 2023: 東京大学, 定量生命科学研究所, 特任研究員 2019: 東京大学, 医科学研究所, 特任研究員 2016 – 2017: 東京大学, 医科学研究所, 特任研究員
Review Section/Research Field	Principal Investigator Basic Section 49030:Experimental pathology-related / General medical chemistry Except Principal Investigator Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Basic Section 56010:Neurosurgery-related
Keywords	Principal Investigator PNH / 造血幹細胞 / PIG-A / ゲノム編集 / iPS細胞 / HSC / 発作性夜間ヘモグロビン尿症 / 骨髄異形成症候群 / 造血障害 / 全ゲノムシーケンス … More / 遺伝子変異修復 / PIGA / 次世代シークエンス / 疾患特異的iPS細胞 / 発作性夜間血色素尿症 / 赤芽球系細胞 / 造血前駆細胞 / Crispr-Cas9 / PIG-A遺伝子 / 遺伝子解析 / iPS細胞樹立法 / 麻疹ウイルスベクター / Measles virus / Naive iPSCs / 幹細胞 / 麻疹ウイルスベクタ / naive iPS細胞 … More Except Principal Investigator 抗腫瘍療法 / 膠芽腫 / 遺伝子治療 / 中枢神経原発リンパ腫 / 血液脳関門 / ウイルスベクター / 間葉系間質細胞 / 遺伝子細胞療法 / 耐性克服 / 腫瘍特異的代謝 / 腫瘍溶解性ウイルス / バイスタンダー効果 / 腫瘍特異的栄養要求性 / 腫瘍溶解ウイルス療法 / 難治性腫瘍 / グリオブラストーマ Less

遺伝子改変間葉系間質細胞を用いた膠芽腫に対する遺伝子細胞療法
- Principal Investigator
  
  曽田泰
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  The University of Tokyo
発作性夜間ヘモグロビン尿症の造血障害に関連した遺伝子異常の機能解析Principal Investigator
- Principal Investigator
  
  廖紀元
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  The University of Tokyo
血液脳関門制御技術の開発：中枢神経腫瘍の治療成績向上を目指して
- Principal Investigator
  
  曽田泰
- Project Period (FY)
  2025 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  The University of Tokyo
Elucidating pathogenesis of hematopoietic dysfunction in PNH using patient-derived iPS cellsPrincipal Investigator
- Principal Investigator
  
  Liao Jiyuan
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  The University of Tokyo
Armored oncolytic virus targeting tumor-specific amino acid metabolism
- Principal Investigator
  
  Soda Yasushi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  The University of Tokyo
Elucidation of pathogenesis of paroxysmal nocturnal hemoglobinuria (PNH) : Strategy to develop a novel therapyPrincipal Investigator
- Principal Investigator
  
  Liao Jiyuan
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  The University of Tokyo
Elucidation of human naive and primed induced pluripotent stem cells directly reprogrammed with measles virus vectorsPrincipal Investigator
- Principal Investigator
  
  Liao Jiyuan
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  General medical chemistry
- Research Institution
  The University of Tokyo

All 2022 2021 2020 2019 2017

All Journal Article Presentation Patent

[Journal Article] Non-transmissible measles virus vector with segmented RNA genome establishes different types of iPSCs from hematopoietic cells2020
- Author(s)
  Hiramoto T, Tahara M, Liao J, Soda Y, Miura Y, Kurita R, Hamana H, Inoue K, Kohara H, Hijikata Y, Okano S, Yamaguchi Y, Oda Y, Ichiyanagi K, Toh H, Sasaki H, Kishi H, Ryo A, Muraguchi A, Takeda M, Tani K
- Journal Title
  
  Mol Ther
  
  Volume: 28 Pages: 129-141
- Data Source
  KAKENHI-PROJECT-19K16606
[Journal Article] A pilot study to establish human T‐cell leukemia virus type 1 (HTLV‐1) carrier model using common marmoset ( Callithrix jacchus )2020
- Author(s)
  Hirose Lisa、Hiramoto Takafumi、Tian Yamin、Kohara Hiroshi、Kobayashi Seiichiro、Nagai Etsuko、Denda Tamami、Tanaka Yukihisa、Ota Yasunori、Jiyuan Liao、Miyamoto Shohei、Miura Yoshie、Hijikata Yasuki、Soda Yasushi、Inoue Takashi、Okahara Norio、Itoh Toshio、Sasaki Erika、Tojo Arinobu、Uchimaru Kaoru、Tani Kenzaburo
- Journal Title
  
  Journal of Medical Primatology
  
  Volume: 49 Issue: 2 Pages: 86-94
- DOI
  10.1111/jmp.12454
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16500, KAKENHI-PROJECT-17H01547, KAKENHI-PROJECT-19K16606
[Journal Article] Regulation of expression and trafficking of perforin-2 by LPS and TNF-α.2017
- Author(s)
  Xiong P, Shiratsuchi M, Matsushima T, Liao J, Tanaka E, Nakashima Y, Takayanagi R, Ogawa Y
- Journal Title
  
  Cell Immunol
  
  Volume: 320 Pages: 1-10
- DOI
  10.1016/j.cellimm.2017.07.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H06746
[Patent] 鎌状赤血球症の改善及び/又は予防剤2019
- Inventor(s)
  谷憲三朗、曽田泰、廖紀元、宮本将平、河田聡史、富岡基康、児玉健
- Industrial Property Rights Holder
  谷憲三朗、曽田泰、廖紀元、宮本将平、河田聡史、富岡基康、児玉健
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-19K16606
[Presentation] 5-アミノレブリン酸とクエン酸第一鉄ナトリウムの併用は鎌状赤血球症モデルマウスの貧血を改善し、LPS誘発致死を防ぐ2022
- Author(s)
  児玉健、曽田泰、廖紀元、宮本将平、四柳宏、谷憲三朗
- Organizer
  第10回ポルフィリン-ALA学会
- Data Source
  KAKENHI-PROJECT-21K15413
[Presentation] 5-Aminolevulinic acid combined with sodium ferrous citrate prevents bleeding stress and LPS-induced lethality in sickle cell disease mouse models.2021
- Author(s)
  Kodama K, Soda Y, Ohno H, Liao J, Miyamoto S, Yotsuyanagi H, Tani K.
- Organizer
  第83回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-21K15413
[Presentation] MicroRNA-Targeted Oncolytic Virotherapy for Triple-Negative Breast Cancer2021
- Author(s)
  Miyamoto S, Ito S, Sagara M, Soda Y, Hara K, Sakamoto A, Liao JY, Kodama K, Tani K
- Organizer
  日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K16606
[Presentation] Non-Integrating Measles Virus Vector is a Promising Tool for Naive iPSCs Generation and T-cell Engineering2020
- Author(s)
  Liao J, Soda Y, Sugawara A, Miura Y, Hiramoto T, Tahara M, Takishima Y, Miyamoto S, Takeda M, Tani K
- Organizer
  American Society of Gene and Cell Therapy 22nd Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16606
[Presentation] Inhibition of sickling by 5-Aminolevulinic Acid in Sickle Cell Disease Mouse Models2020
- Author(s)
  Ken Kodama, Yasushi Soda, Jiyuan Liao, Shohei Miyamoto, Hiroshi Yotsuyanagi and Kenzaburo Tani
- Organizer
  第82回日本血液学会
- Data Source
  KAKENHI-PROJECT-19K16606
[Presentation] Direct induction of naive-like human induced pluripotent stem cells (iPSCs) by a non-integrating measles virus vector2019
- Author(s)
  Liao J, Soda Y, Sugawara A, Miura Y, Hiramoto T, Tahara M, Takishima Y, Hijikata Y, Miyamoto S, Takeda M, Tani K
- Organizer
  第25回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19K16606
[Presentation] Measles virus vector is a promising tool for T-cell engineering and establishing naive-like iPSCs2019
- Author(s)
  Liao J, Soda Y, Sugawara A, Miura Y, Hiramoto T, Tahara M, Takishima Y, Miyamoto S, Hijikata Y, Takeda M, Tani K
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19K16606
[Presentation] Analysis of Human iPSCs Generated by a Non-Integrating Measles Virus Vector2019
- Author(s)
  Liao J, Soda Y, Sugawara A, Miura Y, Hiramoto T, Tahara M, Takishima Y, Hijikata Y, Miyamoto S, Takeda M, Tani K
- Organizer
  American Society of Gene and Cell Therapy 22nd Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16606
[Presentation] Inhibition of sickling by 5-aminolevulinic acid in sickle cell disease mouse models.2019
- Author(s)
  Kodama K, Soda Y, Liao J, Miyamoto S, Deguchi T, Fujine K, Sakata H, Tomioka M, Tani K
- Organizer
  7th International ALA and Porphyrin Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16606
[Presentation] 5-ALAを用いた末梢血循環がん細胞の検出法確立にむけたパイロット研究2019
- Author(s)
  廣瀬理沙、小原洋志、相良京、三浦由恵、土方康基、曽田泰、宮本将平、廖紀元、高橋聡、篠崎大、大田泰徳、渡辺恵理、田中徹、中島元夫、木庭幸子、奥山隆平、福原秀雄、井上啓史、並川努、花﨑和弘、谷憲三朗
- Organizer
  第９回ポルフィリン-ALA学会
- Data Source
  KAKENHI-PROJECT-19K16606
[Presentation] Reprogramming e ciency of human hematopoietic subsets by measles virus vectors2017
- Author(s)
  廖　紀元、小原洋志、平本貴史、田原舞、小川由恵、唐澤伸明、坂本千香、滝嶌佑人、宮本将平、竹田誠、谷憲三朗
- Organizer
  第17回日本再生医療学会
- Data Source
  KAKENHI-PROJECT-16H06746
[Presentation] Successful Reprogramming of Human Hematopoietic Subsets with Non-integrating RNA Measles Virus Vectors2017
- Author(s)
  Jiyuan Liao, Hiroshi Kohara, Takafumi Hiramoto, Maino Tahara, Yoshie Ogawa, Nobuaki Karasawa, Chika Sakamoto, Makoto Takeda, Kenzaburo Tani
- Organizer
  第8回JSH国際シンポジウム（宮崎）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06746
[Presentation] Evaluation of measles virus vectors for reprogramming target human hematopietic subsets2017
- Author(s)
  Liao Jiyuan, Hiroshi Kohara, Takafumi Hiramoto, Maino Tahara, Yoshie Ogawa, Nobuaki Karasawa, Chika Sakamoto, Yuto Takishima, Shohei Miyamoto, Makoto Takeda, Kenzaburo Tani
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16H06746
[Presentation] The utility of a recombinant measles virus in reprogramming with multiple human hematopoietic cells2017
- Author(s)
  Liao Jiyuan, Hiroshi Kohara, Takafumi Hiramoto, Maino Tahara, Yoshie Ogawa, Nobuaki Karasawa, Chika Sakamoto, Yuto Takashima, Shohei Miyamoto, Makoto Takeda, Kenzaburo TaniHiroshi Kohara, Yoshie Ogawa, Shohei Miyamoto, Hiromi Ogura, Taiju Utsugisawa, Hitoshi Kanno, Kenzaburo Tani
- Organizer
  第23回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-16H06746

1. Soda Yasushi (00361618)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. 宮本将平 (20758536)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 岡田尚巳 (00326828)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 古川洋一 (20272560)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 上野志貴子 (40571047)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 松田孝彦 (40313093)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

LIAO JIYUAN 廖 紀元

Liao Jiyuan 廖 紀元

Research Projects

Research Products

Co-Researchers

遺伝子改変間葉系間質細胞を用いた膠芽腫に対する遺伝子細胞療法

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

発作性夜間ヘモグロビン尿症の造血障害に関連した遺伝子異常の機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

血液脳関門制御技術の開発：中枢神経腫瘍の治療成績向上を目指して

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidating pathogenesis of hematopoietic dysfunction in PNH using patient-derived iPS cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Armored oncolytic virus targeting tumor-specific amino acid metabolism

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of pathogenesis of paroxysmal nocturnal hemoglobinuria (PNH) : Strategy to develop a novel therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of human naive and primed induced pluripotent stem cells directly reprogrammed with measles virus vectorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Non-transmissible measles virus vector with segmented RNA genome establishes different types of iPSCs from hematopoietic cells2020

Author(s)

Journal Title

Data Source

[Journal Article] A pilot study to establish human T‐cell leukemia virus type 1 (HTLV‐1) carrier model using common marmoset ( Callithrix jacchus )2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regulation of expression and trafficking of perforin-2 by LPS and TNF-α.2017

Author(s)

Journal Title

DOI

Data Source

[Patent] 鎌状赤血球症の改善及び/又は予防剤2019

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Presentation] 5-アミノレブリン酸とクエン酸第一鉄ナトリウムの併用は鎌状赤血球症モデルマウスの貧血を改善し、LPS誘発致死を防ぐ2022

Author(s)

Organizer

Data Source

[Presentation] 5-Aminolevulinic acid combined with sodium ferrous citrate prevents bleeding stress and LPS-induced lethality in sickle cell disease mouse models.2021

Author(s)

Organizer

Data Source

[Presentation] MicroRNA-Targeted Oncolytic Virotherapy for Triple-Negative Breast Cancer2021

Author(s)

Organizer

Data Source

[Presentation] Non-Integrating Measles Virus Vector is a Promising Tool for Naive iPSCs Generation and T-cell Engineering2020

LIAO JIYUAN 廖紀元

Liao Jiyuan 廖紀元