Tanaka Megumu 田中愛

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tanaka megumu 田中愛

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Researcher Number	90786401
Other IDs
Affiliation (Current)	2025: 信州大学, 医学部, 特任助教
Affiliation (based on the past Project Information) *help	2024: 信州大学, 医学部, 特任助教 2022 – 2024: 信州大学, 医学部, 日本学術振興会特別研究員RPD 2020 – 2021: 信州大学, 医学部, 研究員 2016 – 2017: 信州大学, 医学系研究科, 研究員
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Pathological medical chemistry Except Principal Investigator Medium-sized Section 53:Organ-based internal medicine and related fields / Basic Section 54040:Metabolism and endocrinology-related
Keywords	Principal Investigator リンパ節転移 / 血管恒常性 / アドレノメデュリン / 転移前土壌 / エクソソーム / 高内皮細静脈 / RAMP2 / 癌微小環境 / EndMT / 血管透過性 … More / 癌転移 / 動物 / 遺伝子 / 生理活性 / 癌 / 腫瘍血管新生 … More Except Principal Investigator 転移 / 心血管系 / 慢性臓器障害 / 生活習慣病 Less

AM-RAMPシステムの全容解明と、生活習慣病・慢性臓器障害への治療応用
- Principal Investigator
  
  新藤隆行
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Shinshu University
AM-RAMP2、3系による血管および癌関連線維芽細胞の制御と癌転移抑制法の開発Principal Investigator
- Principal Investigator
  
  田中愛
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Shinshu University
『リバースOnco-Cardiology』の展開による癌転移制御法の開発
- Principal Investigator
  
  新藤隆行
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Shinshu University
Functional regulation of high endothelial venules by the AM-RAMP2 system and its application to the development of methods to suppress cancer metastasisPrincipal Investigator
- Principal Investigator
  
  Tanaka Megumu
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Shinshu University
Elucidation of the Regulatory Mechanism of Cancer Metastasis by the Adrenomedullin-RAMP2, 3 System and Development of Its ApplicationPrincipal Investigator
- Principal Investigator
  
  tanaka megumu
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Shinshu University
Suppression of tumor metastasis based on the vascular homeostasis regulationPrincipal Investigator
- Principal Investigator
  
  Tanaka Megumu
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Shinshu University

All 2024 2023 2022 2021 2020 2018 2017 2016

All Journal Article Presentation Book

[Book] アドレノメデュリン-RAMP2系は、転移前土壌形成を抑制し、癌転移を抑制する2017
- Author(s)
  田中　愛
- Total Pages
  137
- Publisher
  日本心脈管作動物質学会事務局
- Data Source
  KAKENHI-PROJECT-16H06841
[Journal Article] Receptor-activity-modifying proteins of adrenomedullin (RAMP2/3): Roles in the pathogenesis of ARDS2023
- Author(s)
  Kasahara T, Tanaka M, Zhao Y, Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Kawate H, Matsuda Y, Zhang Y, Guo Q, Li P, Hoshiyama K, Li J, Onishi N, Hayashi M, Sanjo H, Ishida K, Tanaka S, Kawamata M, Shindo T
- Journal Title
  
  Peptides
  
  Volume: 171 Pages: 171118-171118
- DOI
  10.1016/j.peptides.2023.171118
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06855, KAKENHI-PROJECT-21K06868, KAKENHI-PROJECT-22K15524, KAKENHI-PROJECT-22KJ1493, KAKENHI-PROJECT-21H02669
[Journal Article] Role of Adrenomedullin 2/Intermedin in the Pathogenesis of Neovascular Age-Related Macular Degeneration2023
- Author(s)
  Kakihara Shinji、Matsuda Yorishige、Hirabayashi Kazutaka、Imai Akira、Iesato Yasuhiro、Sakurai Takayuki、Kamiyoshi Akiko、Tanaka Megumu、Ichikawa-Shindo Yuka、Kawate Hisaka、Zhao Yunlu、Zhang Yan、Guo QianQian、Li Peixuan、Onishi Naho、Murata Toshinori、Shindo Takayuki
- Journal Title
  
  Laboratory Investigation
  
  Volume: 103 Issue: 4 Pages: 100038-100038
- DOI
  10.1016/j.labinv.2022.100038
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15524, KAKENHI-PROJECT-22KJ1493, KAKENHI-PROJECT-22K06855, KAKENHI-PROJECT-23K19652, KAKENHI-PROJECT-21H02669
[Journal Article] Receptor activity modifying protein RAMP sub-isoforms and their functional differentiation, which regulates functional diversity of adrenomedullin2022
- Author(s)
  Shindo T, Tanaka M, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Sakurai T
- Journal Title
  
  Biology(Basel)
  
  Volume: 11(5) Issue: 5 Pages: 788-788
- DOI
  10.3390/biology11050788
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06855, KAKENHI-PROJECT-22K15524, KAKENHI-PROJECT-22KJ1493, KAKENHI-PROJECT-20K07845, KAKENHI-PROJECT-20K09803, KAKENHI-PROJECT-20K21569, KAKENHI-PROJECT-21H02669
[Journal Article] Adrenomedullin ameliorates pulmonary fibrosis by regulating TGF-b-Smads signaling and myofibroblast differentiation2021
- Author(s)
  Wei Y, Tanaka M, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Cui N, Kakihara S, Zhao Y, Aruga K, Sanjo H, Shindo T
- Journal Title
  
  Endocrinology
  
  Volume: 162(8) Issue: 8 Pages: 1-22
- DOI
  10.1210/endocr/bqab090
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07317, KAKENHI-PROJECT-19K07477, KAKENHI-PROJECT-20K16299, KAKENHI-PROJECT-20K07845, KAKENHI-PROJECT-20K09803, KAKENHI-PROJECT-21K06868, KAKENHI-PROJECT-20K21569, KAKENHI-PROJECT-22KJ1493, KAKENHI-PROJECT-21H02669
[Journal Article] Adrenomedullin-receptor activity-modifying protein 2 system ameliorates subretinal fibrosis by suppressing epithelial-mesenchymal transition in age-related macular degeneration2021
- Author(s)
  Tanaka M, Kakihara S, Hirabayashi K, Imai A, Toriyama Y, Iesato Y, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Cui N, Wei Y, Zhao Y, Aruga K, Yamauchi A, Murata T, Shindo T
- Journal Title
  
  Am J Pathol
  
  Volume: 191(4) Issue: 4 Pages: 652-668
- DOI
  10.1016/j.ajpath.2020.12.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07317, KAKENHI-PROJECT-19K07477, KAKENHI-PROJECT-20K07845, KAKENHI-PROJECT-20K09803, KAKENHI-PROJECT-20K21569, KAKENHI-PROJECT-20K16299, KAKENHI-PROJECT-18H02602, KAKENHI-PROJECT-18J40224, KAKENHI-PROJECT-21H02669
[Journal Article] Adrenomedullin-RAMP2 and -RAMP3 systems regulate cardiac homeostasis during cardiovascular stress2021
- Author(s)
  Cui N, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Tanaka M, Wei Y, Kakihara S, Zhao Y, Aruga K, Kawagishi H, Nakada T, Yamada M, Shindo T
- Journal Title
  
  Endocrinology
  
  Volume: 162(3) Issue: 3 Pages: 0-0
- DOI
  10.1210/endocr/bqab001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07317, KAKENHI-PROJECT-20K16299, KAKENHI-PROJECT-18J40224, KAKENHI-PROJECT-19K07477, KAKENHI-PROJECT-20K07845, KAKENHI-PROJECT-20K09803, KAKENHI-PROJECT-20K21569, KAKENHI-PROJECT-21H02669
[Journal Article] Endogenous calcitonin gene-related peptide suppresses ischemic brain injuries and progression of cognitive decline2018
- Author(s)
  Zhai L, Tanaka M, et al.
- Journal Title
  
  J Hypertens.
  
  Volume: 36 Issue: 4 Pages: 876-891
- DOI
  10.1097/hjh.0000000000001649
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06841, KAKENHI-PROJECT-16K15233, KAKENHI-PROJECT-17K08588, KAKENHI-PROJECT-17K09296, KAKENHI-PROJECT-18H02602, KAKENHI-PROJECT-18H00481
[Journal Article] Vasoprotective activities of the adrenomedullin-RAMP2 system in endothelial cells2017
- Author(s)
  Xian X, Tanaka M, et al.
- Journal Title
  
  Endocrinology
  
  Volume: 158 Issue: 5 Pages: 1359-1372
- DOI
  10.1210/en.2016-1531
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06841, KAKENHI-PROJECT-26293085, KAKENHI-PROJECT-26293183, KAKENHI-PROJECT-26460337, KAKENHI-PROJECT-16K08545, KAKENHI-PROJECT-16K15233, KAKENHI-PROJECT-16H00679, KAKENHI-PROJECT-17K08588, KAKENHI-PROJECT-17K09296
[Journal Article] Endogenous calcitonin gene-related peptide regulates lipid metabolism and energy homeostasis in male mice2017
- Author(s)
  Liu T, Tanaka M, et al.
- Journal Title
  
  Endocrinology
  
  Volume: 158 Issue: 5 Pages: 1194-1206
- DOI
  10.1210/en.2016-1510
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06841, KAKENHI-PROJECT-26293085, KAKENHI-PROJECT-26293183, KAKENHI-PROJECT-26460337, KAKENHI-PROJECT-16K08545, KAKENHI-PROJECT-16K15233, KAKENHI-PROJECT-16H00679, KAKENHI-PROJECT-17K08588, KAKENHI-PROJECT-17K09296
[Journal Article] Adrenomedullin Suppresses Vascular Endothelial Growth Factor-Induced Vascular Hyperpermeability and Inflammation in Retinopathy.2017
- Author(s)
  Imai A, Tanaka M, et al.
- Journal Title
  
  Am J Pathol.
  
  Volume: 187 Pages: 999-1015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H06841
[Journal Article] The endothelial adrenomedullin-RAMP2 system regulates vascular integrity and suppresses tumour metastasis2016
- Author(s)
  Tanaka M, et al.
- Journal Title
  
  Cardiovascular Research
  
  Volume: 111 Issue: 4 Pages: 398-409
- DOI
  10.1093/cvr/cvw166
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H06841, KAKENHI-PROJECT-26293183, KAKENHI-PROJECT-26460337, KAKENHI-PROJECT-16K08545, KAKENHI-PROJECT-16H00651, KAKENHI-PROJECT-16H00679
[Presentation] Vascular Homeostasis by the AM-RAMP2 System Promotes T cell Recruitment, Prevents Cancer Cell Migration, and Suppresses Lymph Node Metastasis.2024
- Author(s)
  田中愛
- Organizer
  第88回日本循環器学会
- Data Source
  KAKENHI-PROJECT-22K15524
[Presentation] AM-RAMP2系は、高内皮細静脈(HEV)の恒常性を制御し、リンパ節転移を抑制する2023
- Author(s)
  田中愛
- Organizer
  第6回日本腫瘍循環器学会
- Data Source
  KAKENHI-PROJECT-22K15524
[Presentation] アドレノメデュリン-RAMP2、RAMP3システムの機能分化とがん転移の制御への展開2023
- Author(s)
  田中愛
- Organizer
  第27回日本心血管内分泌代謝学会
- Invited
- Data Source
  KAKENHI-PROJECT-22K15524
[Presentation] Vascular Homeostatic Function of the AM-RAMP2 System and Its Application to the Regulation of Lymph Node Metastasis2023
- Author(s)
  田中愛
- Organizer
  第87回日本循環器学会
- Data Source
  KAKENHI-PROJECT-22K15524
[Presentation] アドレノメデュリン-RAMP2系による、高内皮細静脈を介したリンパ節転移の制御2023
- Author(s)
  田中愛
- Organizer
  第52回日本心脈管作動物質学会
- Data Source
  KAKENHI-PROJECT-22K15524
[Presentation] AM-RAMP2系の血管恒常性制御を介したリンパ節転移抑制作用2022
- Author(s)
  田中愛
- Organizer
  第26回日本心血管内分泌代謝学会
- Data Source
  KAKENHI-PROJECT-22K15524
[Presentation] Regulation of High Endothelial Venules and Suppression of Lymphatic Metastasis by Adrenomedullin-RAMP2 System2022
- Author(s)
  Megumu Tanaka
- Organizer
  第86回　日本循環器学会
- Data Source
  KAKENHI-PROJECT-20K16299
[Presentation] Adrenomedullin-RAMP2 system regulates vascular endothelial homeostasis, which suppresses hematogenous and lymphogeneous metastasis2021
- Author(s)
  Megumu Tanaka
- Organizer
  第85回日本循環器学会
- Data Source
  KAKENHI-PROJECT-20K16299
[Presentation] AM-RAMP2系の血管恒常性制御による血行性、リンパ行性転移抑制機構の解明2021
- Author(s)
  田中愛
- Organizer
  第50回　日本心脈管作動物質学会
- Data Source
  KAKENHI-PROJECT-20K16299
[Presentation] Adrenomedullin-RAMP2 system regulates high endothelial venules in lymph nodes and suppresses lymphatic metastasis2021
- Author(s)
  Megumu Tanaka
- Organizer
  第28回日本血管生物医学会
- Data Source
  KAKENHI-PROJECT-20K16299
[Presentation] AM-RAMP2 系による高内皮細静脈の機能制御とリンパ行性転移抑制作用2021
- Author(s)
  田中愛
- Organizer
  第25回　日本心血管内分泌代謝学会
- Data Source
  KAKENHI-PROJECT-20K16299
[Presentation] AM-RAMP2システムは血管内皮の恒常性を制御し、血行性およびリンパ行性転移を抑制する2020
- Author(s)
  田中愛
- Organizer
  第6回血管生物若手会
- Data Source
  KAKENHI-PROJECT-20K16299
[Presentation] アドレノメデュリン-RAMP2系は、EndMTと転移前土壌形成を抑制し、癌転移を抑制する2017
- Author(s)
  田中　愛
- Organizer
  第46回日本心脈管作動物質学会
- Place of Presentation
  沖縄　琉球大学
- Year and Date
  2017-02-10
- Data Source
  KAKENHI-PROJECT-16H06841
[Presentation] アドレノメデュリン-RAMP2系による血管内皮保護機構の解明2017
- Author(s)
  田中　愛
- Organizer
  第21回日本心血管内分泌代謝学会
- Data Source
  KAKENHI-PROJECT-16H06841
[Presentation] Adrenomedullin-RAMP2 system regulates vascular homeostasis and suppresses tumor metastasis2017
- Author(s)
  Megumu Tanaka
- Organizer
  ERATO/AMED-CREST/PRESTO Joint International Symposium : Organismal and Systems Biology of Inter-Organ Communication
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06841
[Presentation] Adrenomedullin-RAMP2 system inhibits the endothelial　to mesenchymal transition(EndMT) and formation of pre-metastatic niche by maintaining vascular integrity2016
- Author(s)
  田中　愛
- Organizer
  第33回国際心臓研究学会日本部会（ISHR2016）
- Place of Presentation
  東京　東京コンベンションホール
- Year and Date
  2016-12-16
- Data Source
  KAKENHI-PROJECT-16H06841
[Presentation] Adrenomedullin-RAMP2 system inhibits the endothelial-mesenchymal transition and formation of pre-metastatic niche by maintaining vascular integrity2016
- Author(s)
  田中　愛
- Organizer
  The 24th Annual Meeting of the Japanese Vascular Biology and Medicine Organization/The 14th Korea-Japan Joint Symposium on Vascular Biology
- Place of Presentation
  長崎　長崎ブリックホール
- Year and Date
  2016-12-08
- Data Source
  KAKENHI-PROJECT-16H06841

1. 新藤隆行 (90345215)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 桜井敬之 (80317825)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 横山茂之 (00159229)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 神吉昭子 (10397309)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results

Tanaka Megumu 田中 愛

tanaka megumu 田中 愛

Research Projects

Research Products

Co-Researchers

AM-RAMPシステムの全容解明と、生活習慣病・慢性臓器障害への治療応用

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

AM-RAMP2、3系による血管および癌関連線維芽細胞の制御と癌転移抑制法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

『リバースOnco-Cardiology』の展開による癌転移制御法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional regulation of high endothelial venules by the AM-RAMP2 system and its application to the development of methods to suppress cancer metastasisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the Regulatory Mechanism of Cancer Metastasis by the Adrenomedullin-RAMP2, 3 System and Development of Its ApplicationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Suppression of tumor metastasis based on the vascular homeostasis regulationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] アドレノメデュリン-RAMP2系は、転移前土壌形成を抑制し、癌転移を抑制する2017

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Receptor-activity-modifying proteins of adrenomedullin (RAMP2/3): Roles in the pathogenesis of ARDS2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of Adrenomedullin 2/Intermedin in the Pathogenesis of Neovascular Age-Related Macular Degeneration2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Receptor activity modifying protein RAMP sub-isoforms and their functional differentiation, which regulates functional diversity of adrenomedullin2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Adrenomedullin ameliorates pulmonary fibrosis by regulating TGF-b-Smads signaling and myofibroblast differentiation2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Adrenomedullin-receptor activity-modifying protein 2 system ameliorates subretinal fibrosis by suppressing epithelial-mesenchymal transition in age-related macular degeneration2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Adrenomedullin-RAMP2 and -RAMP3 systems regulate cardiac homeostasis during cardiovascular stress2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Endogenous calcitonin gene-related peptide suppresses ischemic brain injuries and progression of cognitive decline2018

Author(s)

Journal Title

DOI

Tanaka Megumu 田中愛

tanaka megumu 田中愛

[Presentation] アドレノメデュリン-RAMP2、RAMP3システムの機能分化とがん転移の制御への展開2023

[Presentation] AM-RAMP2 系による高内皮細静脈の機能制御とリンパ行性転移抑制作用2021