HIGA Nayuta 比嘉那優大

Researcher Number	90792200
Other IDs
Affiliation (Current)	2025: 鹿児島大学, 医歯学域医学系, 助教
Affiliation (based on the past Project Information) *help	2021 – 2023: 鹿児島大学, 医歯学域医学系, 助教 2019 – 2022: 鹿児島大学, 鹿児島大学病院, 医員 2018: 鹿児島大学, 附属病院, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 56010:Neurosurgery-related Except Principal Investigator Basic Section 56010:Neurosurgery-related / Basic Section 52040:Radiological sciences-related / Basic Section 50020:Tumor diagnostics and therapeutics-related
Keywords	Principal Investigator 膠芽腫 / 遺伝子パネル検査 / VUS / 空間的プロテオミクス解析 / プロテオミクス解析 / 意義不明変異 / ゲノムプロファイル / メチル化解析 / 次世代シーケンサー / エピゲノム … More / ゲノム / GBM / ARID1A / TERTp / 遺伝子プロファイル / EGFR / PDGFRA / 遺伝子パネル / フォルミンファミリー / Glioblastoma / GM130 / mDial / Mesenchymal subtype / GM130 (GOLGA2) / mDia1 (DIAPH1) / glioblastoma / migration / invasion / 浸潤・遊走能 / FMNL1 … More Except Principal Investigator 膠芽腫 / グリオーマ / ゲノム編集 / 意義不明変異 / HDAC7 / EGFR / 遺伝子パネル / エピゲノムプロファイル / DNA/RNAパネル / 予後予測モデル / 機械学習 / ゲノムプロファイル / ヒストン脱アセチル化酵素 HDAC7 / NNT / ミトコンドリア代謝酵素 / ヒストン脱アセチル化酵素 / 膠芽腫サブタイプ / Mesenchymal type / Proneural type / WHO2021 / マルチパラメトリックMRI / 神経膠腫 / 細胞密度 / 細胞外拡散 / 細胞内容積比 / 細胞径 / IMPULSEDモデル解析 / 時間依存性拡散強調像 / 転移性脳腫瘍 / 耐性機序 / テモゾロミド / オートファジー / α-Actinin / lipoma preferred partner / FLNC / FMNL1 / 浸潤・遊走能 / 膠芽腫 (Glioblastoma) / LPP / がん遺伝子 / PDGFRA遺伝子 / 飽和ゲノム編集 / Mitochondria / Glioblastoma / glioma / glycolysis / glioblastoma Less

先進的マルチパラメトリックMRIに基づく新分類に即した神経膠腫の診断と予後予測法の開発
- Principal Investigator
  
  上村清央
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Kagoshima University
HDAC7とNNTの相互作用が膠芽腫悪性化に及ぼす影響の解明ー細胞レベルで探るー
- Principal Investigator
  
  高城朋子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Kagoshima University
機械学習によるグリオーマの診断・予後バイオマーカーの創出と個別化医療への基盤構築
- Principal Investigator
  
  花谷亮典
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Kagoshima University
膠芽腫におけるEGFR意義不明変異の機能解析
- Principal Investigator
  
  霧島茉莉
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Kagoshima University
膠芽腫におけるドライバー遺伝子変異の空間的プロテオミクスへの基盤構築Principal Investigator
- Principal Investigator
  
  比嘉那優大
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Kagoshima University
PDGFRA遺伝子変異の抗がん剤感受性マップの作製
- Principal Investigator
  
  濱田大治
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kagoshima University
膠芽腫におけるLPPを中心とした新規浸潤・遊走機構の解明
- Principal Investigator
  
  増田圭亮
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Kagoshima University
悪性神経膠腫におけるテモゾロミド耐性獲得においてオートファジーが果たす役割の解明
- Principal Investigator
  
  米澤大
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Kagoshima University
Comprehensive genomic and epigenomic analysis in Japanese glioma patients using a glioma tailored gene panel.Principal Investigator
- Principal Investigator
  
  HIGA Nayuta
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Kagoshima University
functional significance of HDAC7 expression in glioblastoma focusing on the mitochondria function
- Principal Investigator
  
  Yoshimoto Koji
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Kyushu University
  Kagoshima University
New invasion and migration mechanisms associated with FMNL1 in glioblastomaPrincipal Investigator
- Principal Investigator
  
  HIGA Nayuta
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Kagoshima University

All 2022 2019 2018

All Journal Article Presentation

[Journal Article] Prognostic impact of PDGFRA gain/amplification and MGMT promoter methylation status in patients with IDH wild-type glioblastoma2022
- Author(s)
  Higa N, Akahane T, Yokoyama S, Yonezawa H, Uchida H, Takajo T, Otsuji R, Hamada T, Matsuo K, Kirishima M, Hata N, Hanaya R, Tanimoto A, Yoshimoto K
- Journal Title
  
  Neuro-Oncology Advances
  
  Volume: 4 Issue: 1
- DOI
  10.1093/noajnl/vdac097
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K16636
[Journal Article] Molecular Genetic Profile of 300 Japanese Patients with Diffuse Gliomas Using a Glioma-tailored Gene Panel2022
- Author(s)
  Higa N, Akahane T, Yokoyama S, Yonezawa H, Uchida H, Fujio S, Kirishima M, Takigawa K, Hata N, Toh K, Yamamoto J, Hanaya R, Tanimoto A, Yoshimoto K
- Journal Title
  
  Neurol. Med. Chir.(Tokyo)
  
  Volume: 62 Issue: 9 Pages: 391-399
- DOI
  10.2176/jns-nmc.2022-0103
- ISSN
  0470-8105, 1349-8029
- Year and Date
  2022-09-15
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K16636
[Journal Article] Distribution and favorable prognostic implication of genomic EGFR alterations in IDH-wildtype glioblastoma.2022
- Author(s)
  Higa N, Akahane T, Hamada T, Yonezawa H, Uchida H, Makino R, Watanabe S, Takajo T, Yokoyama S, Kirishima M, Matsuo K, Fujio S, Hanaya R, Tanimoto A, Yoshimoto K
- Journal Title
  
  Cancer Medicine
  
  Volume: 12 Issue: 1 Pages: 49-60
- DOI
  10.1002/cam4.4939
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K16636
[Journal Article] Formin-like 1 (FMNL1) Is Associated with Glioblastoma Multiforme Mesenchymal Subtype and Independently Predicts Poor Prognosis2019
- Author(s)
  Higa N, Shinsato Y, Kamil M, Hirano T, Takajo T, Shimokawa M, Minami K, Yamamoto M, Kawahara K, Yonezawa H, Hirano H, Furukawa T, Yoshimoto K, Arita K
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Issue: 24 Pages: 6355-6355
- DOI
  10.3390/ijms20246355
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07221, KAKENHI-PROJECT-19K22566, KAKENHI-PROJECT-18K15248, KAKENHI-PROJECT-16K07121, KAKENHI-PROJECT-18K16590, KAKENHI-PROJECT-16H06276
[Presentation] カスタムNGSパネルを用いたグリオーマ300例の解析-分子プロファイルの特徴と予後バイオマーカー-2022
- Author(s)
  比嘉　那優大
- Organizer
  日本脳腫瘍学会
- Data Source
  KAKENHI-PROJECT-21K16636
[Presentation] IDH wild-type GBMにおけるPDGFRA amplificationおよびMGMTpメチル化の予後への影響2022
- Author(s)
  比嘉　那優大
- Organizer
  日本脳腫瘍病理学会
- Data Source
  KAKENHI-PROJECT-21K16636
[Presentation] カスタム遺伝子パネルを用いて解析したグリオーマ300例の遺伝子プロファイルとWHO2021分類に基づく再分類2022
- Author(s)
  比嘉　那優大
- Organizer
  日本脳神経外科学会総会
- Data Source
  KAKENHI-PROJECT-21K16636
[Presentation] IDH wild-type GBMにおけるPDGFRA amplificationの予後への影響2022
- Author(s)
  比嘉　那優大
- Organizer
  日本分子脳外科学会
- Data Source
  KAKENHI-PROJECT-21K16636
[Presentation] Glioblastomaにおけるアクチン重合因子であるFormin-like 1 (FMNL1)の機能解析2019
- Author(s)
  比嘉　那優大
- Organizer
  日本分子脳神経外科学会
- Data Source
  KAKENHI-PROJECT-18K16590
[Presentation] Function of Formin-like 1 (FMNL1) in Glioblastoma Multiforme2019
- Author(s)
  Nayuta Higa
- Organizer
  Society for neurooncology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16590
[Presentation] Formin-like1(FMNL1)はGlioblastomaの独立した予後不良因子であり、浸潤・遊走能を促進させる2018
- Author(s)
  比嘉　那優大
- Organizer
  第77回日本脳神経外科学会総会
- Data Source
  KAKENHI-PROJECT-18K16590
[Presentation] GlioblastomaにおけるFormin-like1(FMNL1)の機能について2018
- Author(s)
  比嘉　那優大
- Organizer
  第36回日本脳腫瘍学会
- Data Source
  KAKENHI-PROJECT-18K16590

1. 米澤大 (50550076)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. 花谷亮典 (60304424)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. 濱田大治 (30771480)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. 谷本昭英 (10217151)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. 横山勢也 (20569941)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. 高城朋子 (50972345)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. Yoshimoto Koji (70444784)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 内田裕之 (80404482)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 赤羽俊章 (70754480)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 増田圭亮 (60934411)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 上村清央 (30593652)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 吉浦敬 (40322747)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 中野翼 (50876761)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 中條正典 (60727171)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 長谷川知仁 (70912856)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 藤尾信吾 (30464473)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 霧島茉莉 (10899967)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. KAWAHARA Kohichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HIGA Nayuta 比嘉 那優大

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膠芽腫におけるドライバー遺伝子変異の空間的プロテオミクスへの基盤構築Principal Investigator

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Comprehensive genomic and epigenomic analysis in Japanese glioma patients using a glioma tailored gene panel.Principal Investigator

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New invasion and migration mechanisms associated with FMNL1 in glioblastomaPrincipal Investigator

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[Journal Article] Prognostic impact of PDGFRA gain/amplification and MGMT promoter methylation status in patients with IDH wild-type glioblastoma2022

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[Journal Article] Molecular Genetic Profile of 300 Japanese Patients with Diffuse Gliomas Using a Glioma-tailored Gene Panel2022

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[Journal Article] Distribution and favorable prognostic implication of genomic EGFR alterations in IDH-wildtype glioblastoma.2022

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HIGA Nayuta 比嘉那優大