HIGA Nayuta 比嘉那優大

Researcher Number	90792200
Other IDs
Affiliation (Current)	2026: 鹿児島大学, 医歯学域医学系, 助教
Affiliation (based on the past Project Information) *help	2021 – 2024: 鹿児島大学, 医歯学域医学系, 助教 2019 – 2022: 鹿児島大学, 鹿児島大学病院, 医員 2018: 鹿児島大学, 附属病院, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 56010:Neurosurgery-related Except Principal Investigator Basic Section 56010:Neurosurgery-related / Basic Section 52040:Radiological sciences-related / Basic Section 50020:Tumor diagnostics and therapeutics-related
Keywords	Principal Investigator 膠芽腫 / 遺伝子パネル検査 / VUS / 空間的プロテオミクス解析 / プロテオミクス解析 / 意義不明変異 / ゲノムプロファイル / メチル化解析 / 次世代シーケンサー / エピゲノム … More / ゲノム / GBM / ARID1A / TERTp / 遺伝子プロファイル / EGFR / PDGFRA / 遺伝子パネル / フォルミンファミリー / Glioblastoma / GM130 / mDial / Mesenchymal subtype / GM130 (GOLGA2) / mDia1 (DIAPH1) / glioblastoma / migration / invasion / 浸潤・遊走能 / FMNL1 … More Except Principal Investigator 膠芽腫 / グリオーマ / ゲノム編集 / 意義不明変異 / HDAC7 / EGFR / 遺伝子パネル / エピゲノムプロファイル / DNA/RNAパネル / ゲノムプロファイル / 予後予測モデル / 機械学習 / ヒストン脱アセチル化酵素 HDAC7 / NNT / ミトコンドリア代謝酵素 / ヒストン脱アセチル化酵素 / 膠芽腫サブタイプ / Mesenchymal type / Proneural type / WHO2021 / マルチパラメトリックMRI / 神経膠腫 / 細胞密度 / 細胞内容積比 / 細胞内容積 / 細胞密度比 / 細胞径 / 細胞外拡散 / IMPULSEDモデル解析 / 時間依存性拡散強調像 / 転移性脳腫瘍 / 耐性機序 / テモゾロミド / オートファジー / α-Actinin / lipoma preferred partner / FLNC / FMNL1 / 浸潤・遊走能 / 膠芽腫 (Glioblastoma) / LPP / がん遺伝子 / PDGFRA遺伝子 / 飽和ゲノム編集 / Mitochondria / Glioblastoma / glioma / glycolysis / glioblastoma Less

先進的マルチパラメトリックMRIに基づく新分類に即した神経膠腫の診断と予後予測法の開発
- Principal Investigator
  
  上村清央
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Kagoshima University
HDAC7とNNTの相互作用が膠芽腫悪性化に及ぼす影響の解明ー細胞レベルで探るー
- Principal Investigator
  
  高城朋子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Kagoshima University
機械学習によるグリオーマの診断・予後バイオマーカーの創出と個別化医療への基盤構築
- Principal Investigator
  
  花谷亮典
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Kagoshima University
膠芽腫におけるEGFR意義不明変異の機能解析
- Principal Investigator
  
  霧島茉莉
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Kagoshima University
膠芽腫におけるドライバー遺伝子変異の空間的プロテオミクスへの基盤構築Principal Investigator
- Principal Investigator
  
  比嘉那優大
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Kagoshima University
Anticancer drug sensitivity mapping of PDGFRA mutations
- Principal Investigator
  
  Hamada Taiji
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kagoshima University
Elucidation of Novel Mechanisms of Invasion and Migration Focusing on LPP in Glioblastoma
- Principal Investigator
  
  MASUDA Keisuke
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Kagoshima University
Clarification of the role of autophagy in the acquisition of temozolomide resistance in malignant gliomas.
- Principal Investigator
  
  YONEZAWA Hajime
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Kagoshima University
Comprehensive genomic and epigenomic analysis in Japanese glioma patients using a glioma tailored gene panel.Principal Investigator
- Principal Investigator
  
  HIGA Nayuta
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Kagoshima University
functional significance of HDAC7 expression in glioblastoma focusing on the mitochondria function
- Principal Investigator
  
  Yoshimoto Koji
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Kyushu University
  Kagoshima University
New invasion and migration mechanisms associated with FMNL1 in glioblastomaPrincipal Investigator
- Principal Investigator
  
  HIGA Nayuta
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Kagoshima University

All 2025 2024 2022 2019 2018

All Journal Article Presentation

[Journal Article] Higher Uptake of Preoperative 11C-Methionine Positron Emission Tomography Related to Preoperative Seizure in Patients With Oligodendroglioma2025
- Author(s)
  Bajagain Madan、Sakamoto Akihisa、Takajo Tomoko、Makino Ryutaro、Uchida Hiroyuki、Masuda Keisuke、Higa Nayuta、Yonezawa Hajime、Yatsushiro Kazutaka、Tanimoto Akihide、Hanaya Ryosuke
- Journal Title
  
  Cureus
  
  Volume: 17(1)
- DOI
  10.7759/cureus.76991
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09238
[Journal Article] Prognosis prediction via histological evaluation of cellular heterogeneity in glioblastoma2024
- Author(s)
  Kirishima M, Yokoyama S, Akahane T, Higa N, Uchida H, Yonezawa H, Matsuo K, Yamamoto J, Yoshimoto K, Hanaya R, Tanimoto A.
- Journal Title
  
  Scientific Reports
  
  Volume: 14 Issue: 1 Pages: 24955-24955
- DOI
  10.1038/s41598-024-76826-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K08525, KAKENHI-PROJECT-23K08546
[Journal Article] All-in-one bimodal DNA and RNA next-generation sequencing panel for integrative diagnosis of glioma2024
- Author(s)
  Higa N, Akahane T, Kirishima M, Yonezawa H, Makino R, Uchida H, Yokoyama S, Takajo T, Otsuji R, Fujioka Y, Sangatsuda Y, Kuga D, Yamahata H, Hata N, Horie N, Kurosaki M, Yamamoto J, Yoshimoto K, Tanimoto A, Hanaya R
- Journal Title
  
  Pathology - Research and Practice
  
  Volume: 263 Pages: 155598-155598
- DOI
  10.1016/j.prp.2024.155598
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K08525, KAKENHI-PROJECT-23K08546, KAKENHI-PROJECT-23K10453
[Journal Article] Distribution and favorable prognostic implication of genomic EGFR alterations in IDH-wildtype glioblastoma.2022
- Author(s)
  Higa N, Akahane T, Hamada T, Yonezawa H, Uchida H, Makino R, Watanabe S, Takajo T, Yokoyama S, Kirishima M, Matsuo K, Fujio S, Hanaya R, Tanimoto A, Yoshimoto K
- Journal Title
  
  Cancer Medicine
  
  Volume: 12 Issue: 1 Pages: 49-60
- DOI
  10.1002/cam4.4939
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K16636
[Journal Article] Prognostic impact of PDGFRA gain/amplification and MGMT promoter methylation status in patients with IDH wild-type glioblastoma2022
- Author(s)
  Higa N, Akahane T, Yokoyama S, Yonezawa H, Uchida H, Takajo T, Otsuji R, Hamada T, Matsuo K, Kirishima M, Hata N, Hanaya R, Tanimoto A, Yoshimoto K
- Journal Title
  
  Neuro-Oncology Advances
  
  Volume: 4 Issue: 1
- DOI
  10.1093/noajnl/vdac097
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K16636
[Journal Article] Molecular Genetic Profile of 300 Japanese Patients with Diffuse Gliomas Using a Glioma-tailored Gene Panel2022
- Author(s)
  Higa N, Akahane T, Yokoyama S, Yonezawa H, Uchida H, Fujio S, Kirishima M, Takigawa K, Hata N, Toh K, Yamamoto J, Hanaya R, Tanimoto A, Yoshimoto K
- Journal Title
  
  Neurol. Med. Chir.(Tokyo)
  
  Volume: 62 Issue: 9 Pages: 391-399
- DOI
  10.2176/jns-nmc.2022-0103
- ISSN
  0470-8105, 1349-8029
- Year and Date
  2022-09-15
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K16636
[Journal Article] Formin-like 1 (FMNL1) Is Associated with Glioblastoma Multiforme Mesenchymal Subtype and Independently Predicts Poor Prognosis2019
- Author(s)
  Higa N, Shinsato Y, Kamil M, Hirano T, Takajo T, Shimokawa M, Minami K, Yamamoto M, Kawahara K, Yonezawa H, Hirano H, Furukawa T, Yoshimoto K, Arita K
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Issue: 24 Pages: 6355-6355
- DOI
  10.3390/ijms20246355
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07221, KAKENHI-PROJECT-19K22566, KAKENHI-PROJECT-18K15248, KAKENHI-PROJECT-16K07121, KAKENHI-PROJECT-18K16590, KAKENHI-PROJECT-16H06276
[Presentation] WHO新分類(WHO2021)の課題とその克服2:脳腫瘍病理形態診断と分子診断の融合の可能性グリオーマに特化したカスタムDNA/RNAパネルを用いたクリニカルシーケンス2024
- Author(s)
  比嘉　那優大
- Organizer
  日本脳腫瘍病理学会
- Data Source
  KAKENHI-PROJECT-23K08546
[Presentation] 小児脳腫瘍におけるカスタムDNA/RNAパネルを用いたクリニカルシーケンス2024
- Author(s)
  比嘉　那優大
- Organizer
  日本小児神経外科学会
- Data Source
  KAKENHI-PROJECT-23K08546
[Presentation] カスタムDNA/RNAパネルを用いた多施設共同研究の現状2024
- Author(s)
  比嘉　那優大
- Organizer
  日本脳腫瘍学会
- Data Source
  KAKENHI-PROJECT-23K08546
[Presentation] カスタムDNA/RNAパネルの脳腫瘍診断・スクリーニングとしての意義2024
- Author(s)
  比嘉　那優大
- Organizer
  日本脳神経外科学会総会
- Data Source
  KAKENHI-PROJECT-23K08546
[Presentation] IDH wild-type GBMにおけるPDGFRA amplificationおよびMGMTpメチル化の予後への影響2022
- Author(s)
  比嘉　那優大
- Organizer
  日本脳腫瘍病理学会
- Data Source
  KAKENHI-PROJECT-21K16636
[Presentation] カスタム遺伝子パネルを用いて解析したグリオーマ300例の遺伝子プロファイルとWHO2021分類に基づく再分類2022
- Author(s)
  比嘉　那優大
- Organizer
  日本脳神経外科学会総会
- Data Source
  KAKENHI-PROJECT-21K16636
[Presentation] IDH wild-type GBMにおけるPDGFRA amplificationの予後への影響2022
- Author(s)
  比嘉　那優大
- Organizer
  日本分子脳外科学会
- Data Source
  KAKENHI-PROJECT-21K16636
[Presentation] カスタムNGSパネルを用いたグリオーマ300例の解析-分子プロファイルの特徴と予後バイオマーカー-2022
- Author(s)
  比嘉　那優大
- Organizer
  日本脳腫瘍学会
- Data Source
  KAKENHI-PROJECT-21K16636
[Presentation] Glioblastomaにおけるアクチン重合因子であるFormin-like 1 (FMNL1)の機能解析2019
- Author(s)
  比嘉　那優大
- Organizer
  日本分子脳神経外科学会
- Data Source
  KAKENHI-PROJECT-18K16590
[Presentation] Function of Formin-like 1 (FMNL1) in Glioblastoma Multiforme2019
- Author(s)
  Nayuta Higa
- Organizer
  Society for neurooncology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16590
[Presentation] GlioblastomaにおけるFormin-like1(FMNL1)の機能について2018
- Author(s)
  比嘉　那優大
- Organizer
  第36回日本脳腫瘍学会
- Data Source
  KAKENHI-PROJECT-18K16590
[Presentation] Formin-like1(FMNL1)はGlioblastomaの独立した予後不良因子であり、浸潤・遊走能を促進させる2018
- Author(s)
  比嘉　那優大
- Organizer
  第77回日本脳神経外科学会総会
- Data Source
  KAKENHI-PROJECT-18K16590

1. YONEZAWA Hajime (50550076)

# of Collaborated Projects: 6 results

# of Collaborated Products: 3 results
2. 花谷亮典 (60304424)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
3. Hamada Taiji (30771480)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. 谷本昭英 (10217151)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. 横山勢也 (20569941)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. 高城朋子 (50972345)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
7. Yoshimoto Koji (70444784)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 内田裕之 (80404482)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
9. 赤羽俊章 (70754480)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. MASUDA Keisuke (60934411)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 上村清央 (30593652)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 吉浦敬 (40322747)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 中野翼 (50876761)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 中條正典 (60727171)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 長谷川知仁 (70912856)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 藤尾信吾 (30464473)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. 霧島茉莉 (10899967)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. KAWAHARA Kohichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HIGA Nayuta 比嘉 那優大

Research Projects

Research Products

Co-Researchers

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

膠芽腫におけるドライバー遺伝子変異の空間的プロテオミクスへの基盤構築Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Comprehensive genomic and epigenomic analysis in Japanese glioma patients using a glioma tailored gene panel.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

New invasion and migration mechanisms associated with FMNL1 in glioblastomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Higher Uptake of Preoperative 11C-Methionine Positron Emission Tomography Related to Preoperative Seizure in Patients With Oligodendroglioma2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prognosis prediction via histological evaluation of cellular heterogeneity in glioblastoma2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] All-in-one bimodal DNA and RNA next-generation sequencing panel for integrative diagnosis of glioma2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Distribution and favorable prognostic implication of genomic EGFR alterations in IDH-wildtype glioblastoma.2022

Author(s)

Journal Title

HIGA Nayuta 比嘉那優大

[Presentation] WHO新分類(WHO2021)の課題とその克服2:脳腫瘍病理形態診断と分子診断の融合の可能性グリオーマに特化したカスタムDNA/RNAパネルを用いたクリニカルシーケンス2024