LAURINO Paola ＬＡＵＲＩＮＯＰａｏｌａ

… Alternative Names

Laurino Paola LAURINO Paola

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Researcher Number	90812256
Other IDs	https://orcid.org/0000-0002-3725-2645
Affiliation (Current)	2026: 沖縄科学技術大学院大学, タンパク質工学・進化ユニット, 教授
Affiliation (based on the past Project Information) *help	2026: 沖縄科学技術大学院大学, タンパク質工学・進化ユニット, 准教授 2024: 沖縄科学技術大学院大学, タンパク質工学・進化ユニット, 准教授 2018 – 2021: 沖縄科学技術大学院大学, タンパク質工学・進化ユニット, 准教授
Review Section/Research Field	Principal Investigator Basic Section 43040:Biophysics-related / Basic Section 43040:Biophysics-related / Basic Section 43030:Functional biochemistry-related / Basic Section 43020:Structural biochemistry-related / Basic Section 43030:Functional biochemistry-related
Keywords	Principal Investigator metabolon / Krebs cycle / enzyme engineering / metabolism / Enzyme evolution / kinetics / droplets / LLPS / phase-separation / molecular dynamics … More / protein crowding / Enzyme / evolution / RNA modification / mistranslation / tRNA / screening / library / enzyme / Biochemistry / Liquid phase separation / protocells / AGT / Disordered regions / protein plasticity / protein engineering / enzyme kinetic / enzymes / Phase separation / Cofactors / Directed evolution / Protein Engineering / coenzyme engineering / kinetic assays / Methyltransferases / methionine / SAM analogues / Coenzyme engineering / compartimentalisation / In-vitro / RNA methyltransferase / adenosyltransferase / Methionine / directed evolution / S-adenosyl methionine Less

異なる翻訳タンパク質を生じさせるゲノムレベルでのフレームシフトモチーフの理解Principal Investigator
- Principal Investigator
  
  LAURINO Paola
- Project Period (FY)
  2026 – 2027
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Review Section
  
  Basic Section 43040:Biophysics-related
- Research Institution
  Okinawa Institute of Science and Technology Graduate University
Unraveling enzyme functions in liquid -liquid phase separation dropletsPrincipal Investigator
- Principal Investigator
  
  LAURINO Paola
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43040:Biophysics-related
- Research Institution
  Okinawa Institute of Science and Technology Graduate University
最小タンパク質の設計：最小ロスマンフォールドの探索と小型抗体への応用Principal Investigator
- Principal Investigator
  
  LAURINO Paola
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Review Section
  
  Basic Section 43040:Biophysics-related
- Research Institution
  Okinawa Institute of Science and Technology Graduate University
新たなレベルの制御？混雑した微小環境における一過性のクレブスサイクル複合体の追跡Principal Investigator
- Principal Investigator
  
  LAURINO Paola
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Review Section
  
  Basic Section 43040:Biophysics-related
- Research Institution
  Okinawa Institute of Science and Technology Graduate University
tRNA修飾ランドスケープが新規タンパク質機能の進化に与える影響Principal Investigator
- Principal Investigator
  
  LAURINO Paola
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Okinawa Institute of Science and Technology Graduate University
非天然型アミノ酸生産のためのPLP依存性アミノ基転移酵素の改変Principal Investigator
- Principal Investigator
  
  LAURINO Paola
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Okinawa Institute of Science and Technology Graduate University
Coenzyme engineering for the study of RNA methyltransferasePrincipal Investigator
- Principal Investigator
  
  Laurino Paola
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Okinawa Institute of Science and Technology Graduate University

All 2025 2024 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Dynamic Cytoplasm: A Physical Regulator of Enzymatic Function2025
- Author(s)
  Erika Fukuhara, Elsie Dunkley, Alessandro Bevilacqua, Paola Laurino
- Journal Title
  
  ACS Biochemistry
  
  Volume: -
- Data Source
  KAKENHI-PROJECT-24KF0078
[Journal Article] SUPREM: an engineered site-specific m6A RNA methyltransferase with highly improved efficiency.2024
- Author(s)
  Ochiai, Y., Clifton, B.E., Le Coz, M., Terenzio, M., Laurino, P.
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 52 Issue: 20 Pages: 12158-12172
- DOI
  10.1093/nar/gkae887
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K13889, KAKENHI-PROJECT-18K14656
[Journal Article] Enzyme Activity Regulates Substrate Diffusion by Modulating Viscosity in Crowded Milieu2024
- Author(s)
  Alessandro Bevilacqua, Mauricio Rios Maciel, Stefano Pascarelli, Mirco Dindo, Amy Q. Shen, Paola Laurino
- Journal Title
  
  biorxiv (電子)
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K14656
[Journal Article] Efficient Exploration of Sequence Space by Sequence-Guided Protein Engineering and Design2022
- Author(s)
  Clifton Ben E.、Kozome Dan、Laurino Paola
- Journal Title
  
  Biochemistry
  
  Volume: In press Issue: 2 Pages: 210-220
- DOI
  10.1021/acs.biochem.1c00757
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20F20705
[Journal Article] Structural dynamics shape the fitness window of alanine:glyoxylate aminotransferase2022
- Author(s)
  Dindo Mirco、Pascarelli Stefano、Chiasserini Davide、Grottelli Silvia、Costantini Claudio、Uechi Gen‐Ichiro、Giardina Giorgio、Laurino Paola、Cellini Barbara
- Journal Title
  
  Protein Science
  
  Volume: 31 Issue: 5 Pages: 1-10
- DOI
  10.1002/pro.4303
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19F19764
[Journal Article] Sustained enzymatic activity and flow in crowded protein droplets2021
- Author(s)
  Testa Andrea、Dindo Mirco、Rebane Aleksander A.、Nasouri Babak、Style Robert W.、Golestanian Ramin、Dufresne Eric R.、Laurino Paola
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 1-10
- DOI
  10.1038/s41467-021-26532-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19F19764
[Journal Article] Evolutionary repair reveals an unexpected role of the tRNA modification m1G37 in aminoacylation2021
- Author(s)
  Clifton Ben E、Fariz Muhammad A、Uechi Gen-Ichiro、Laurino Paola
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 49 Issue: 21 Pages: 12467-12485
- DOI
  10.1093/nar/gkab1067
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20F20705
[Journal Article] Non-enzymatic and highly sensitive lactose detection utilizing graphene field-effect transistors2020
- Author(s)
  Danielson Eric、Dindo Mirco、Porkovich Alexander J.、Kumar Pawan、Wang Zhenwei、Jain Prashant、Mete Trimbak、Ziadi Zakaria、Kikkeri Raghavendra、Laurino Paola、Sowwan Mukhles
- Journal Title
  
  Biosensors and Bioelectronics
  
  Volume: 165 Pages: 112419-112419
- DOI
  10.1016/j.bios.2020.112419
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19F19764
[Journal Article] Cycloserine enantiomers are reversible inhibitors of human alanine:glyoxylate aminotransferase: implications for Primary Hyperoxaluria type 12019
- Author(s)
  Mirco Dindo; Silvia Grottelli; Giannamaria Annunziato; Giorgio Giardina; Marco Pieroni; Gioena Pampalone; Andrea Faccini; Francesca Cutruzzola; Paola Laurino; Gabriele Costantino; Barbara Cellini
- Journal Title
  
  Biochem J
  
  Volume: 476 Issue: 24 Pages: 3751-3768
- DOI
  10.1042/bcj20190507
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19F19764
[Presentation] How do proteins expand functionality?2025
- Author(s)
  LAURINOPaola
- Organizer
  理研インターナショナルカンファレンス
- Data Source
  KAKENHI-PROJECT-18K14656
[Presentation] How do proteins expand functionality?2025
- Author(s)
  Paola Laurino
- Organizer
  IPR International Conference 2025
- Invited
- Data Source
  KAKENHI-PROJECT-24K01995
[Presentation] Indels : The Evolutionary Switches Bridging Protein Functions and Topologies2024
- Author(s)
  LAURINOPaola
- Organizer
  第21回国際生物物理会議
- Data Source
  KAKENHI-PROJECT-18K14656
[Presentation] Indels : The Evolutionary Switches Bridging : Protein Functions and Topologies2024
- Author(s)
  LAURINOPaola
- Organizer
  the pre-ISBC
- Data Source
  KAKENHI-PROJECT-18K14656
[Presentation] How do proteins expand functionality?2024
- Author(s)
  LAURINOPaola
- Organizer
  日本農芸化学会中部支部第200回例会
- Data Source
  KAKENHI-PROJECT-18K14656

1. DINDO MIRCO

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
2. CLIFTON BENJAMIN

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
3. DUNKLEY ELSIE

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. HONZEJKOVA KAROLINA

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. AUBEL MARGAUX

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

LAURINO Paola ＬＡＵＲＩＮＯ Ｐａｏｌａ

Laurino Paola LAURINO Paola

Research Projects

Research Products

Co-Researchers

異なる翻訳タンパク質を生じさせるゲノムレベルでのフレームシフトモチーフの理解Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Unraveling enzyme functions in liquid -liquid phase separation dropletsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

最小タンパク質の設計：最小ロスマンフォールドの探索と小型抗体への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

新たなレベルの制御？混雑した微小環境における一過性のクレブスサイクル複合体の追跡Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

tRNA修飾ランドスケープが新規タンパク質機能の進化に与える影響Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

非天然型アミノ酸生産のためのPLP依存性アミノ基転移酵素の改変Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Coenzyme engineering for the study of RNA methyltransferasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Dynamic Cytoplasm: A Physical Regulator of Enzymatic Function2025

Author(s)

Journal Title

Data Source

[Journal Article] SUPREM: an engineered site-specific m6A RNA methyltransferase with highly improved efficiency.2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Enzyme Activity Regulates Substrate Diffusion by Modulating Viscosity in Crowded Milieu2024

Author(s)

Journal Title

Data Source

[Journal Article] Efficient Exploration of Sequence Space by Sequence-Guided Protein Engineering and Design2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural dynamics shape the fitness window of alanine:glyoxylate aminotransferase2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sustained enzymatic activity and flow in crowded protein droplets2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Evolutionary repair reveals an unexpected role of the tRNA modification m1G37 in aminoacylation2021

Author(s)

Journal Title

DOI

Data Source

LAURINO Paola ＬＡＵＲＩＮＯＰａｏｌａ