Himiyama Tomoki 氷見山幹基

Researcher Number	90828310
Other IDs	https://orcid.org/0000-0001-5252-1834
Affiliation (Current)	2025: 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究員
Affiliation (based on the past Project Information) *help	2024: 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究員 2018 – 2022: 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究員
Review Section/Research Field	Principal Investigator Basic Section 37010:Bio-related chemistry / 0501:Physical chemistry, functional solid state chemistry, organic chemistry, polymers, organic materials, biomolecular chemistry, and related fields Except Principal Investigator Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
Keywords	Principal Investigator ペルオキシレドキシン / 化学修飾 / タンパク質集合体 / タンパク質 / 分子修飾 / エックス線結晶構造解析 / 四次構造 / 金属錯体 / 人工金属酵素 Except Principal Investigator ペルオキシレドキシン … More / 超分子複合体 / 分子会合 / 四次構造 / Peroxiredoxin Less

ペルオキシレドキシンを基盤とした光応答性タンパク質ケージの設計と構築Principal Investigator
- Principal Investigator
  
  氷見山幹基
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Structural and functional regulation of a ring-type protein quaternary structurePrincipal Investigator
- Principal Investigator
  
  Himiyama Tomoki
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Supramolecular complex of peroxiredoxin
- Principal Investigator
  
  Nakamura Tsutomu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Development of an artificial metalloenzyme based on a peroxiredoxin from hyperthermophilic archaeaPrincipal Investigator
- Principal Investigator
  
  Himiyama Tomoki
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0501:Physical chemistry, functional solid state chemistry, organic chemistry, polymers, organic materials, biomolecular chemistry, and related fields
- Research Institution
  National Institute of Advanced Industrial Science and Technology

All 2023 2022 2021 2020 2019

All Journal Article Presentation Patent

[Journal Article] Unnaturally Distorted Hexagonal Protein Ring Alternatingly Reorganized from Two Distinct Chemically Modified Proteins2023
- Author(s)
  Himiyama Tomoki、Hamaguchi Tasuku、Yonekura Koji、Nakamura Tsutomu
- Journal Title
  
  Bioconjugate Chemistry
  
  Volume: 34 Pages: 764-771
- DOI
  10.1021/acs.bioconjchem.3c00057
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05740
[Journal Article] Functional analysis of the N‐terminal region of acetylxylan esterase from Caldanaerobacter subterraneus subsp. tengcongensis2022
- Author(s)
  Sasamoto Kohei、Himiyama Tomoki、Moriyoshi Kunihiko、Ohmoto Takashi、Uegaki Koichi、Nakamura Tsutomu、Nishiya Yoshiaki
- Journal Title
  
  FEBS Open Bio
  
  Volume: 12 Issue: 10 Pages: 1875-1885
- DOI
  10.1002/2211-5463.13476
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05740
[Journal Article] Reducing substrate inhibition of malate dehydrogenase from Geobacillus stearothermophilus by C-terminal truncation2022
- Author(s)
  Shimozawa Yuya、Matsuhisa Hinano、Nakamura Tsutomu、Himiyama Tomoki、Nishiya Yoshiaki
- Journal Title
  
  Protein Engineering, Design and Selection
  
  Volume: 35
- DOI
  10.1093/protein/gzac008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05740
[Journal Article] Structural analysis and reaction mechanism of malate dehydrogenase from Geobacillus stearothermophilus2021
- Author(s)
  Shimozawa Yuya、Himiyama Tomoki、Nakamura Tsutomu、Nishiya Yoshiaki
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: － Issue: 1 Pages: 97-105
- DOI
  10.1093/jb/mvab027
- NAID
  40022723378
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K15403, KAKENHI-PROJECT-18K06616, KAKENHI-PROJECT-20K05740
[Journal Article] Increasing loop flexibility affords low-temperature adaptation of a moderate thermophilic malate dehydrogenase from Geobacillus stearothermophilus.2021
- Author(s)
  Yuya Shimozawa, Tomoki Himiyama, Tsutomu Nakamura, Yoshiaki Nishiya
- Journal Title
  
  Protein Engineering Design and Selection
  
  Volume: 34
- DOI
  10.1093/protein/gzab026
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06616, KAKENHI-PROJECT-20K15403
[Journal Article] Crystal structure of acetylxylan esterase from Caldanaerobacter subterraneus subsp. tengcongensis.2021
- Author(s)
  Kohei Sasamoto, Tomoki Himiyama, Kunihiko Moriyoshi, Takashi Ohmoto, Koichi Uegaki, Yoshiaki Nishiya, Tsutomu Nakamura
- Journal Title
  
  Acta Crystallographica
  
  Volume: F77 Issue: 11 Pages: 399-406
- DOI
  10.1107/s2053230x21009675
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06616, KAKENHI-PROJECT-20K15403, KAKENHI-PROJECT-20K05740
[Journal Article] Increasing loop flexibility affords low-temperature adaptation of a moderate thermophilic malate dehydrogenase from Geobacillus stearothermophilus2021
- Author(s)
  Yuya Shimozawa, Tomoki Himiyama, Tsutomu Nakamura, Yoshiaki Nishiya
- Journal Title
  
  Protein Engineering Design & Selection
  
  Volume: 34 Pages: 1-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05740
[Journal Article] Artificial Metalloenzymes: From Selective Chemical Transformations to Biochemical Applications2020
- Author(s)
  Himiyama Tomoki、Okamoto Yasunori
- Journal Title
  
  Molecules
  
  Volume: 25 Issue: 13 Pages: 2989-2989
- DOI
  10.3390/molecules25132989
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K15403
[Journal Article] Disassembly of the ring‐type decameric structure of peroxiredoxin from Aeropyrum pernix K1 by amino acid mutation2020
- Author(s)
  Himiyama Tomoki、Nakamura Tsutomu
- Journal Title
  
  Protein Science
  
  Volume: 29 Issue: 5 Pages: 1138-1147
- DOI
  10.1002/pro.3837
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K21133, KAKENHI-PROJECT-20K05740
[Journal Article] Rebuilding Ring-Type Assembly of Peroxiredoxin by Chemical Modification2020
- Author(s)
  Himiyama Tomoki、Tsuchiya Yuko、Yonezawa Yasushige、Nakamura Tsutomu
- Journal Title
  
  Bioconjugate Chemistry
  
  Volume: 32 Issue: 1 Pages: 153-160
- DOI
  10.1021/acs.bioconjchem.0c00587
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K05620, KAKENHI-PROJECT-20K05740, KAKENHI-PROJECT-20K15403
[Journal Article] Distinct molecular assembly of homologous peroxiredoxins from Pyrococcus horikoshii and Thermococcus kodakaraensis2019
- Author(s)
  Himiyama Tomoki、Oshima Maki、Uegaki Koichi、Nakamura Tsutomu
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 未定 Issue: 1 Pages: 89-95
- DOI
  10.1093/jb/mvz013
- NAID
  40021952200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K01815, KAKENHI-PROJECT-19K21133
[Patent] ペルオキシレドキシンに基づく人工ヘテロオリゴマータンパク質2021
- Inventor(s)
  氷見山幹基、中村努
- Industrial Property Rights Holder
  国立研究開発法人産業技術総合研究所
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-137971
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-20K05740
[Patent] ペルオキシレドキシンに基づく人工ヘテロオリゴマータンパク質2021
- Inventor(s)
  氷見山幹基、中村努
- Industrial Property Rights Holder
  国立研究開発法人産業技術総合研究所
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-137971
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-20K15403
[Presentation] 精製工程の違いによる金属依存性糖脱アセチル化酵素の活性と立体構造への影響2023
- Author(s)
  佐々本康平、氷見山幹基、武田悠杜、張宇琪、森芳邦彦、大本貴士、上垣浩一、西矢芳昭、中村努
- Organizer
  日本農芸化学会2023年度大会
- Data Source
  KAKENHI-PROJECT-20K05740
[Presentation] 好熱菌由来糖脱アセチル化酵素の基質結合部位改変と構造解析2023
- Author(s)
  武田悠杜、佐々本康平、氷見山幹基、張宇琪、森芳邦彦、大本貴士、上垣浩一、西矢芳昭、中村努
- Organizer
  日本農芸化学会2023年度大会
- Data Source
  KAKENHI-PROJECT-20K05740
[Presentation] サルコシンオキシダーゼのL-プロリンに対する反応機構の解析2023
- Author(s)
  張宇琪、中嶋義隆、佐々本康平、武田悠杜、氷見山幹基、中村努、西矢芳昭
- Organizer
  第33回生物試料分析科学会合同年次学術集会
- Data Source
  KAKENHI-PROJECT-20K05740
[Presentation] 糖脱アセチル化酵素TTE0866が有する天然変性N末端領域の役割2022
- Author(s)
  佐々本康平、氷見山幹基、森芳邦彦、大本貴士、上垣浩一、西矢芳昭、中村努
- Organizer
  第20回産総研・産技連LS-BT合同研究発表会
- Data Source
  KAKENHI-PROJECT-20K05740
[Presentation] 化学修飾によるペルオキシレドキシン環状交互ヘテロ集合の構築2022
- Author(s)
  氷見山幹基、濵口祐、米倉功治、中村努
- Organizer
  令和4年度日本結晶学会年会
- Data Source
  KAKENHI-PROJECT-20K05740
[Presentation] Caldanaerobacterポリサッカライドデアセチラーゼの反応機構解析2022
- Author(s)
  武田悠杜、佐々本康平、氷見山幹基、森芳邦彦、大本貴士、上垣浩一、西矢芳昭、中村努
- Organizer
  第74回日本生物工学会大会
- Data Source
  KAKENHI-PROJECT-20K05740
[Presentation] 溶解性と凝集抑制に必要な好熱菌由来アセチルキシランエステラーゼの天然変性領域2022
- Author(s)
  佐々本康平、下澤勇弥、氷見山幹基、森芳邦彦、大本貴士、上垣浩一、西矢芳昭、中村努
- Organizer
  第22回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-20K05740
[Presentation] サルコシンオキシダーゼのL-プロリンに対する反応機構の解析2022
- Author(s)
  張宇琪、中嶋義隆、下澤勇弥、佐々本康平、氷見山幹基、中村努、西矢芳昭
- Organizer
  第74回日本生物工学会大会
- Data Source
  KAKENHI-PROJECT-20K05740
[Presentation] Rebuilding and altering ring-type assembly of peroxiredoxin by chemical modification2021
- Author(s)
  氷見山幹基、中村努
- Organizer
  第21回日本蛋白質科学年会
- Data Source
  KAKENHI-PROJECT-20K15403
[Presentation] Rebuilding ring-type decameric assembly of peroxiredoxin by chemical modification2021
- Author(s)
  氷見山幹基、中村努
- Organizer
  日本化学会第101春季年会
- Data Source
  KAKENHI-PROJECT-20K15403
[Presentation] Rebuilding and altering ring-type assembly of peroxiredoxin by chemical modification2021
- Author(s)
  氷見山幹基、中村努
- Organizer
  第21回日本蛋白質科学年会
- Data Source
  KAKENHI-PROJECT-20K05740
[Presentation] 複雑で巨大な環状タンパク質の構造制御2021
- Author(s)
  氷見山幹基、中村努
- Organizer
  産業技術支援フェアin KANSAI 2021
- Data Source
  KAKENHI-PROJECT-20K15403
[Presentation] 環状タンパク質多量体の構造制御2021
- Author(s)
  氷見山幹基、中村努
- Organizer
  第19回産総研・産技連LS-BT合同研究発表会
- Data Source
  KAKENHI-PROJECT-20K05740
[Presentation] 環状タンパク質多量体の構造制御2021
- Author(s)
  氷見山幹基、中村努
- Organizer
  第19回産総研・産技連LS-BT合同研究発表会
- Data Source
  KAKENHI-PROJECT-20K15403
[Presentation] Controlling ring-type assembly of peroxiredoxin by chemical modification2020
- Author(s)
  氷見山幹基、中村努
- Organizer
  日本化学会第100春季年会
- Data Source
  KAKENHI-PROJECT-19K21133
[Presentation] 活性部位の進化により分岐したリンゴ酸脱水素酵素の基質認識2020
- Author(s)
  下澤勇弥、佐々本康平、氷見山幹基、西矢芳昭、中村努
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K05740
[Presentation] The Structural Change Mechanism In The Catalytic Cycle Of Malate Dehydrogenase2020
- Author(s)
  下澤勇弥、西矢芳昭、佐々本康平、氷見山幹基、中村努
- Organizer
  第20回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-20K05740
[Presentation] Disassembly and reassembly of ring-type structure of peroxiredoxin by manipulating hydrophobic interaction2020
- Author(s)
  氷見山幹基、中村努
- Organizer
  第20回蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-20K15403
[Presentation] X-ray crystallographic analysis of acetylxylan esterase from Caldanaerobacter subterraneus2020
- Author(s)
  佐々本康平、下澤勇弥、氷見山幹基、森芳邦彦、大本貴士、上垣浩一、西矢芳昭、中村努
- Organizer
  第20回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-20K05740
[Presentation] 天然変性タンパク質としてのアセチルキシランエステラーゼの構造・機能解析2020
- Author(s)
  佐々本康平、下澤勇弥、氷見山幹基、森芳邦彦、大本貴士、上垣浩一、西矢芳昭、中村努
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K05740
[Presentation] Disassembly and Reassembly of Ring-type Structure of Peroxiredoxin by Manipulating Hydrophobic Interaction2020
- Author(s)
  氷見山幹基、中村努
- Organizer
  第20回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-20K05740
[Presentation] 環状十量体タンパク質Aeropyrum pernix K1由来ペルオキシレドキシンの集合挙動制御2019
- Author(s)
  氷見山幹基、中村努
- Organizer
  第13回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-19K21133
[Presentation] Aeropyrum pernix K1由来ペルオキシレドキシンの環状四次構造を解離する変異導入2019
- Author(s)
  氷見山幹基、中村努
- Organizer
  第19回日本蛋白質科学会年会・第71回日本細胞生物学会大会
- Data Source
  KAKENHI-PROJECT-19K21133
[Presentation] Controlling ring-type decameric assembly of peroxiredoxin from Aeropyrum pernix K1 by combining amino acid mutation and chemical modification2019
- Author(s)
  Tomoki Himiyama, Tsutomu Nakamura
- Organizer
  16th Conference on the Asian Crystallographic Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21133
[Presentation] 変異導入によるペルオキシレドキシンの環状四次構造解離2019
- Author(s)
  氷見山幹基、中村努
- Organizer
  第18回産総研・産技連LS-BT合同研究発表会
- Data Source
  KAKENHI-PROJECT-19K21133

1. Nakamura Tsutomu (10357668)

# of Collaborated Projects: 1 results

# of Collaborated Products: 20 results
2. 秋山健太郎 (41001366)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. UEGAKI Kouichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 西矢芳昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. 米澤康滋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Himiyama Tomoki 氷見山 幹基

Research Projects

Research Products

Co-Researchers

ペルオキシレドキシンを基盤とした光応答性タンパク質ケージの設計と構築Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structural and functional regulation of a ring-type protein quaternary structurePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Supramolecular complex of peroxiredoxin

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of an artificial metalloenzyme based on a peroxiredoxin from hyperthermophilic archaeaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Unnaturally Distorted Hexagonal Protein Ring Alternatingly Reorganized from Two Distinct Chemically Modified Proteins2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Functional analysis of the N‐terminal region of acetylxylan esterase from Caldanaerobacter subterraneus subsp. tengcongensis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Reducing substrate inhibition of malate dehydrogenase from Geobacillus stearothermophilus by C-terminal truncation2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural analysis and reaction mechanism of malate dehydrogenase from Geobacillus stearothermophilus2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Increasing loop flexibility affords low-temperature adaptation of a moderate thermophilic malate dehydrogenase from Geobacillus stearothermophilus.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Crystal structure of acetylxylan esterase from Caldanaerobacter subterraneus subsp. tengcongensis.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Increasing loop flexibility affords low-temperature adaptation of a moderate thermophilic malate dehydrogenase from Geobacillus stearothermophilus2021

Author(s)

Journal Title

Data Source

[Journal Article] Artificial Metalloenzymes: From Selective Chemical Transformations to Biochemical Applications2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Disassembly of the ring‐type decameric structure of peroxiredoxin from Aeropyrum pernix K1 by amino acid mutation2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Rebuilding Ring-Type Assembly of Peroxiredoxin by Chemical Modification2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Distinct molecular assembly of homologous peroxiredoxins from Pyrococcus horikoshii and Thermococcus kodakaraensis2019

Author(s)

Himiyama Tomoki 氷見山幹基