Kakiuchi Nobuyuki 垣内伸之

Researcher Number	90839721
Other IDs
Affiliation (Current)	2025: 京都大学, 白眉センター, 特定准教授
Affiliation (based on the past Project Information) *help	2021 – 2025: 京都大学, 白眉センター, 特定准教授 2020 – 2021: 京都大学, 医学研究科, 助教
Review Section/Research Field	Principal Investigator Medium-sized Section 50:Oncology and related fields / Basic Section 50010:Tumor biology-related Except Principal Investigator Basic Section 53010:Gastroenterology-related / Basic Section 56010:Neurosurgery-related
Keywords	Principal Investigator クローン進化 / ドライバー変異 / ドライバー遺伝子 / 慢性炎症 / クローン拡大 / 発がん / 食道癌 / 細胞周期 / 染色体コピー数変化 / ルゴール不染体 … More / 前がん病変 / 食道がん / 自然選択 / 前癌病変 / ゲノム異常 / バイオインフォマティクス / 網羅的ゲノム解析 / 腫瘍進化 / 大腸がん / オルガノイド / 遺伝子変異 / 陽性選択 / 体細胞変異 / 胆管がん / 原発性硬化性胆管炎 … More Except Principal Investigator 食道がん / 3次元的網羅的ゲノム解析 / 先制医療 / IDH変異型クローン / 正常脳 / グリオーマ / 発癌 / 胆嚢 / 遺伝子多型 / 遺伝子変異 / アルコール発がん / リスク因子 / 食道扁平上皮癌 / 老化 / ゲノム解析 / 食道扁平上皮 / 網羅的ゲノム解析 / ヨード不染色 / 上皮内腫瘍 / 食道扁平上皮がん / がんの起源 / ヨード不染 / 喫煙 / 飲酒 Less

生体組織環境におけるがんの陰性選択メカニズムの解明Principal Investigator
- Principal Investigator
  
  垣内伸之
- Project Period (FY)
  2025 – 2029
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Kyoto University
アルコール長期曝露による正常食道上皮に生じる変異負荷や微小環境変化の解明
- Principal Investigator
  
  横山顕礼
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kyoto University
慢性炎症を背景とした胆嚢癌の発癌メカニズムの解明
- Principal Investigator
  
  西川義浩
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kyoto University
Study of the mechanism of transformation in human esophageal epithelial cellsPrincipal Investigator
- Principal Investigator
  
  Kakiuchi Nobuyuki
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Kyoto University
Investigation of development mechanism and preemptive medicine for IDH-mutant glioma based on genomic analysis of normal brain tissues
- Principal Investigator
  
  荒川芳輝
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Kyoto University
Study on pathogenesis and cancer development in primary sclerosing cholangitis by genetic analysis of biliary epitheliumPrincipal Investigator
- Principal Investigator
  
  Kakiuchi Nobuyuki
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Kyoto University
Deciphering colorectal carcinogenesis by the genomic analysis of colorectal epithelial cellsPrincipal Investigator
- Principal Investigator
  
  Kakiuchi Nobuyuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kyoto University
Early genomic aberrations in esophageal carcinogenesis: Comprehensive genomic analysis of multiple lugol voiding lesions
- Principal Investigator
  
  Yokoyama Akira
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kyoto University

All 2024 2023 2022 2021 2020

All Journal Article Presentation Patent

[Journal Article] Clonal expansion in normal tissues2024
- Author(s)
  Maeda Hirona、Kakiuchi Nobuyuki
- Journal Title
  
  Cancer Science
  
  Volume: . Issue: 7 Pages: 2117-2124
- DOI
  10.1111/cas.16183
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19457
[Journal Article] A novel <i>SREBF1::NACC1</i> gene fusion in an unclassifiable intracranial tumour2022
- Author(s)
  Takeuchi Yasuhide、Mineharu Yohei、Arakawa Yoshiki、Hara Masayuki、Oichi Yuki、Kamata Takahiko、Fukuyama Keita、Yamamoto Yoshihiro、Yamanaka Toshiyuki、Kakiuchi Nobuyuki、Hiratomo Emi、Hirata Masahiro、Yokoo Hideaki、Hirose Takanori、Minamiguchi Sachiko、Ogawa Seishi、Muto Manabu、Miyamoto Susumu、Haga Hironori
- Journal Title
  
  Neuropathology and Applied Neurobiology
  
  Volume: 48 Issue: 7 Pages: 66-73
- DOI
  10.1111/nan.12843
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15972, KAKENHI-PROJECT-23K24445
[Journal Article] Expansion of gastric intestinal metaplasia with copy number aberrations contributes to field cancerization2022
- Author(s)
  Kumagai Ken、Shimizu Takahiro、Takai Atsushi、Kakiuchi Nobuyuki、Takeuchi Yasuhide、Hirano Tomonori、Takeda Haruhiko、Mizuguchi Aya、Teramura Mari、Ito Takahiko、Iguchi Eriko、Nikaido Mitsuhiro、Eso Yuji、Takahashi Ken、Ueda Yoshihide、Miyamoto Shin-ichi、Obama Kazutaka、Ogawa Seishi、Marusawa Hiroyuki、Seno Hiroshi
- Journal Title
  
  Cancer Research
  
  Volume: - Issue: 9 Pages: 1712-1723
- DOI
  10.1158/0008-5472.can-21-1523
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15781, KAKENHI-PROJECT-20H03513, KAKENHI-PROJECT-21K15972, KAKENHI-PROJECT-21K19480, KAKENHI-PROJECT-20H03659, KAKENHI-PROJECT-21K20836
[Journal Article] Clonal expansion in non-cancer tissues2021
- Author(s)
  Kakiuchi Nobuyuki、Ogawa Seishi
- Journal Title
  
  Nature Reviews Cancer
  
  Volume: 21 Issue: 4 Pages: 239-256
- DOI
  10.1038/s41568-021-00335-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21543, KAKENHI-PROJECT-20H03513, KAKENHI-INTERNATIONAL-15K21741, KAKENHI-PROJECT-19H05656
[Patent] 食道癌、咽頭癌又は口腔癌の発症予測及び/又はリスク判定方法、並びに食道癌、咽頭癌又は口腔癌の発症予測及び/又はリスク判定用キット2024
- Inventor(s)
  横山顕礼、垣内伸之、小川誠司、武藤学
- Industrial Property Rights Holder
  横山顕礼、垣内伸之、小川誠司、武藤学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2024-061000
- Filing Date
  2024
- Data Source
  KAKENHI-PROJECT-22K19457
[Presentation] 腫瘍進化の多様性2023
- Author(s)
  垣内伸之
- Organizer
  第61回日本がん治療学会
- Invited
- Data Source
  KAKENHI-PROJECT-22K19457
[Presentation] Evolutionary history of breast cancer2023
- Author(s)
  垣内伸之
- Organizer
  Radiation Biology Center Mini-symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19457
[Presentation] Early cancer evolution2023
- Author(s)
  垣内伸之
- Organizer
  第82回日本癌学会学術総会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19457
[Presentation] 食道扁平上皮癌の生物進化2023
- Author(s)
  横山顕礼、平野智紀、石田雄大、菊池理、竹内康英、南口早智子、小川誠司、武藤学、垣内伸之
- Organizer
  第82回日本癌学会学術総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19457
[Presentation] 正常組織におけるクローン拡大と発がん2022
- Author(s)
  垣内伸之
- Organizer
  がん予防学術大会2022京都
- Invited
- Data Source
  KAKENHI-PROJECT-20H03513
[Presentation] 正常組織におけるクローン拡大と発がん2022
- Author(s)
  垣内伸之
- Organizer
  がん予防学術大会2022京都
- Invited
- Data Source
  KAKENHI-PROJECT-22K19457
[Presentation] Clonal expansion in normal tisues2022
- Author(s)
  垣内伸之
- Organizer
  The 40th Sapporo International Cancer Symposium
- Invited
- Data Source
  KAKENHI-PROJECT-22K19457
[Presentation] Clonal expansion in normal tisues2022
- Author(s)
  Nobuyuki Kakiuchi
- Organizer
  The 40th Sapporo International Cancer Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03513
[Presentation] 潰瘍性大腸炎における上皮細胞のクローン進化2021
- Author(s)
  垣内伸之
- Organizer
  第29回日本癌病態治療研究会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03513
[Presentation] 炎症性腸疾患の発癌メカニズム2021
- Author(s)
  垣内伸之
- Organizer
  日本消化器病学会近畿支部第65回教育講演会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03513
[Presentation] 慢性炎症に伴う胆管上皮におけるクローン拡大2021
- Author(s)
  前田紘奈、垣内伸之、伊藤孝司、小川絵里、塩川雅広、宇座徳光、田中洋子、南谷泰仁、牧島秀樹、保田宏明、児玉裕三、上本伸二、宮野悟、小川誠司
- Organizer
  第80回日本癌学会学術総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21543
[Presentation] On the origin of cancer2021
- Author(s)
  垣内伸之
- Organizer
  第80回日本癌学会学術総会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03513
[Presentation] 慢性炎症に伴う胆管上皮におけるクローン拡大2020
- Author(s)
  前田紘奈, 垣内伸之, 平野智紀, 竹内康英, 伊藤孝司, 小川絵里, 塩川雅広, 宇座徳光, 田中洋子, 南谷泰仁, 牧島秀樹, 上本伸二, 宮野悟, 小川誠司
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K21543
[Presentation] 胃神経内分泌腫瘍の遺伝子異常2020
- Author(s)
  垣内伸之
- Organizer
  除菌時代について考える会2020
- Invited
- Data Source
  KAKENHI-PROJECT-20H03513
[Presentation] 潰瘍性大腸炎における大腸上皮細胞のクローン進化について2020
- Author(s)
  垣内伸之
- Organizer
  第57回日本消化器免疫学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03513
[Presentation] 潰瘍性大腸炎における大腸上皮細胞のクローン進化と発がん2020
- Author(s)
  垣内伸之, 妹尾浩, 小川誠司
- Organizer
  第62回日本消化器病学会大会(JDDW2020)
- Invited
- Data Source
  KAKENHI-PROJECT-20H03513
[Presentation] 潰瘍性大腸炎における上皮細胞のクローン進化と大腸発がん2020
- Author(s)
  垣内伸之, 小川誠司
- Organizer
  第43回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03513

1. Yokoyama Akira (20515514)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
2. 玉置将司 (00796948)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 妹尾浩 (90335266)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 小川誠司 (60292900)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 大橋真也 (20435556)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 西川義浩 (80802785)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 荒川芳輝 (20378649)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 棗田学 (00515728)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 中川正宏 (10431850)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 土井大輔 (10587851)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 竹内康英

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 清水孝洋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kakiuchi Nobuyuki 垣内 伸之

Research Projects

Research Products

Co-Researchers

生体組織環境におけるがんの陰性選択メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

アルコール長期曝露による正常食道上皮に生じる変異負荷や微小環境変化の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

慢性炎症を背景とした胆嚢癌の発癌メカニズムの解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of the mechanism of transformation in human esophageal epithelial cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of development mechanism and preemptive medicine for IDH-mutant glioma based on genomic analysis of normal brain tissues

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study on pathogenesis and cancer development in primary sclerosing cholangitis by genetic analysis of biliary epitheliumPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Deciphering colorectal carcinogenesis by the genomic analysis of colorectal epithelial cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Early genomic aberrations in esophageal carcinogenesis: Comprehensive genomic analysis of multiple lugol voiding lesions

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Clonal expansion in normal tissues2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A novel <i>SREBF1::NACC1</i> gene fusion in an unclassifiable intracranial tumour2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Expansion of gastric intestinal metaplasia with copy number aberrations contributes to field cancerization2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clonal expansion in non-cancer tissues2021

Author(s)

Journal Title

DOI

Data Source

[Patent] 食道癌、咽頭癌又は口腔癌の発症予測及び/又はリスク判定方法、並びに食道癌、咽頭癌又は口腔癌の発症予測及び/又はリスク判定用キット2024

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

[Presentation] 腫瘍進化の多様性2023

Kakiuchi Nobuyuki 垣内伸之