MIYATA Hiroshi 宮田大資

Researcher Number	90844415
Other IDs
Affiliation (Current)	2025: 東京大学, 医学部附属病院, 助教
Affiliation (based on the past Project Information) *help	2019 – 2024: 東京大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related / 0801:Pharmaceutical sciences and related fields Except Principal Investigator Medium-sized Section 58:Society medicine, nursing, and related fields
Keywords	Principal Investigator 骨髄抑制 / 抗がん剤 / トランスポーター / 尿酸 / ABCG2/BCRP / フェブキソスタット / 腫瘍崩壊症候群 / ABCG2 / 薬物相互作用 / 新規薬効標的 … More / GLUT12/SLC2A12 / 生活習慣病 / 痛風 / CRISPR-Cas9 / 遺伝子欠損マウス … More Except Principal Investigator 国際共同研究 / 尿酸 / GWAS / 痛風 / 高尿酸血症 Less

血清尿酸値が抗がん剤の副作用に与える影響の検討Principal Investigator
- Principal Investigator
  
  宮田大資
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  The University of Tokyo
An international (Japan-USA-Vietnam) collaborative research for molecular genetic epidemiology in urate-related diseases including gout and hyperuricemia
- Principal Investigator
  
  松尾洋孝
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Fund for the Promotion of Joint International Research (International Collaborative Research)
- Review Section
  
  Medium-sized Section 58:Society medicine, nursing, and related fields
- Research Institution
  National Defense Medical College
Elucidation of the clinical significance of drug interactions mediated by ABCG2 inhibition on hematopoietic stem cellsPrincipal Investigator
- Principal Investigator
  
  Miyata Hiroshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  The University of Tokyo
International collaborative study on the genetic factors that regulate serum urate levels in humans: clinico-genetic analyses and functional studies focusing on urate transporters
- Principal Investigator
  
  Matsuo Hirotaka
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 58:Society medicine, nursing, and related fields
- Research Institution
  National Defense Medical College
Impact of a novel urate transporter on the regulation of the blood urate level.Principal Investigator
- Principal Investigator
  
  MIYATA Hiroshi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0801:Pharmaceutical sciences and related fields
- Research Institution
  The University of Tokyo

All 2024 2023 2022 2021 2020 2019 Other

All Journal Article Presentation Other

[Journal Article] Membrane Transporter (s)–mediated Regulation of Urate and Vitamin C Behavior in the Body2024
- Author(s)
  Miyata Hiroshi、Toyoda Yu、Takada Tappei
- Journal Title
  
  MEMBRANE
  
  Volume: 49 Issue: 2 Pages: 70-76
- DOI
  10.5360/membrane.49.70
- ISSN
  0385-1036, 1884-6440
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15293, KAKENHI-PROJECT-23K21618
[Journal Article] SVCT2/SLC23A2 is a sodium-dependent urate transporter: functional properties and practical application.2023
- Author(s)
  Toyoda Y, Miyata H, Shigesawa R, Matsuo H, Suzuki H, Takada T.
- Journal Title
  
  J Biol Chem
  
  Volume: 299 Issue: 8 Pages: 104976-104976
- DOI
  10.1016/j.jbc.2023.104976
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22KK0152, KAKENHI-PROJECT-22K19369, KAKENHI-PROJECT-21K15293, KAKENHI-PROJECT-20H00566, KAKENHI-PROJECT-20H00568, KAKENHI-PROJECT-23K21618
[Journal Article] Elevation of tacrolimus concentration after administration of methotrexate for treatment of graft-versus-host disease in pediatric patients received allogeneic hematopoietic stem cell transplantation2023
- Author(s)
  Inoue Chiaki、Yamamoto Takehito、Miyata Hiroshi、Suzuki Hiroshi、Takada Tappei
- Journal Title
  
  Journal of Pharmaceutical Health Care and Sciences
  
  Volume: 9 Issue: 1
- DOI
  10.1186/s40780-023-00306-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15293
[Journal Article] Recent Advances in Research on Vitamin C Transporters2023
- Author(s)
  Toyoda Yu、Miyata Hiroshi、Takada Tappei
- Journal Title
  
  Nippon Eiyo Shokuryo Gakkaishi
  
  Volume: 76 Issue: 4 Pages: 193-198
- DOI
  10.4327/jsnfs.76.193
- ISSN
  0287-3516, 1883-2849
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15293, KAKENHI-PROJECT-23K21618
[Journal Article] Identification of an exporter that regulates vitamin C supply from blood to the brain2022
- Author(s)
  Miyata Hiroshi、Toyoda Yu、Takada Tappei、Hiragi Toshimitsu、Kubota Yu、Shigesawa Ryuichiro、Koyama Ryuta、Ikegaya Yuji、Suzuki Hiroshi
- Journal Title
  
  iScience
  
  Volume: 25 Issue: 1 Pages: 103642-103642
- DOI
  10.1016/j.isci.2021.103642
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15293, KAKENHI-PROJECT-23K21618
[Journal Article] GLUT12の生理的重要性－尿酸の体内動態制御および脳へのビタミンC供給の観点から.2022
- Author(s)
  豊田優、宮田大資、高田龍平
- Journal Title
  
  生化学
  
  Volume: 94 Pages: 599-604
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15293
[Journal Article] 近年明らかになってきた血清尿酸値を規定する尿酸トランスポーター2022
- Author(s)
  宮田大資, 井上智景, 高田龍平
- Journal Title
  
  痛風と尿酸・核酸
  
  Volume: 46 Pages: 1-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15293
[Journal Article] 尿酸トランスポーター：ABCG2/BCRPに関する最近の知見と近年の尿酸トランスポーター研究の進展について2021
- Author(s)
  宮田大資、高田龍平
- Journal Title
  
  ファルマシア
  
  Volume: 57 Pages: 902-906
- NAID
  130008095687
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15293
[Journal Article] Identification of GLUT12/SLC2A12 as a urate transporter that regulates the blood urate level in hyperuricemia model mice.2020
- Author(s)
  Toyoda Y, Takada T, Miyata H, Matsuo H, Kassai H, Nakao K, Nakatochi M, Kawamura Y, Shimizu S, Shinomiya N, Ichida K, Hosoyamada M, Aiba A, Suzuki H
- Journal Title
  
  Proc. Natl.Acad. Sci. USA
  
  Volume: 117 Issue: 31 Pages: 18175-18177
- DOI
  10.1073/pnas.2006958117
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06478, KAKENHI-PROJECT-20H00566, KAKENHI-PROJECT-18H02685, KAKENHI-PROJECT-19K23793, KAKENHI-PROJECT-18KK0247, KAKENHI-PROJECT-20H00568
[Journal Article] Omega-3 Polyunsaturated Fatty Acids Inhibit the Function of Human URAT1, a Renal Urate Re-Absorber2020
- Author(s)
  Saito Hiroki、Toyoda Yu、Takada Tappei、Hirata Hiroshi、Ota-Kontani Ami、Miyata Hiroshi、Kobayashi Naoyuki、Tsuchiya Youichi、Suzuki Hiroshi
- Journal Title
  
  Nutrients
  
  Volume: 12 Issue: 6 Pages: 1601-1601
- DOI
  10.3390/nu12061601
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K23793, KAKENHI-PROJECT-18KK0247, KAKENHI-PROJECT-20H00568
[Presentation] 痛風・尿酸核酸領域のアップデート～最近の論文まとめ読み～2024
- Author(s)
  桑原政成、田中敦史、宮田大資、福内友子、水田栄之助、森川渚、大内基司、藏城雅文、丸橋達也、明石直之、青木雄平、西宮健介、田中仁啓、大谷直由、森田美穂子、阿部弘太郎
- Organizer
  第57回日本痛風・尿酸核酸学会総会
- Data Source
  KAKENHI-PROJECT-21K15293
[Presentation] 高尿酸血症治療に用いられる薬剤と注意点2023
- Author(s)
  宮田大資、高田龍平
- Organizer
  第44回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-21K15293
[Presentation] イトラコナゾール内用液からイトラコナゾールカプセルへ変更後のタクロリムスの血中濃度変化2023
- Author(s)
  正木寛、宮田大資、川島光明、此枝千尋、佐藤雅昭、高田龍平
- Organizer
  第33回日本医療薬学会年会
- Data Source
  KAKENHI-PROJECT-21K15293
[Presentation] 新規ビタミンC排出輸送体としてのSLC2A12の同定および生理的役割の解明2022
- Author(s)
  豊田優、宮田大資、平木俊光、窪田優、重澤龍一郎、小山隆太、池谷裕二、鈴木洋史、高田龍平
- Organizer
  第40回日本ヒト細胞学会学術集会
- Data Source
  KAKENHI-PROJECT-21K15293
[Presentation] GLUT12/SLC2A12は脳内のビタミンC濃度を制御するトランスポーターである2022
- Author(s)
  宮田大資、豊田優、鈴木洋史、高田龍平
- Organizer
  第16回次世代を担う若手のための医療薬科学シンポジウム
- Data Source
  KAKENHI-PROJECT-21K15293
[Presentation] 新規尿酸輸送体GLUT12/SLC2A12の生理的重要性の解析2021
- Author(s)
  宮田大資、高田龍平、豊田優、鈴木洋史
- Organizer
  医療薬学フォーラム2021第29回クリニカルファーマシーシンポジウム
- Data Source
  KAKENHI-PROJECT-21K15293
[Presentation] ω-3脂肪酸が尿酸再吸収輸送体URAT1の尿酸輸送活性に与える影響2021
- Author(s)
  豊田優、齋藤弘貴、高田龍平、平田拓、紺谷愛美、宮田大資、小林直之、土屋陽一、鈴木洋史
- Organizer
  第75回日本栄養・食糧学会大会
- Data Source
  KAKENHI-PROJECT-21K15293
[Presentation] 膜輸送体研究の方法～巨人の肩に立ち、輸送体の囁きを聴く～　新規尿酸輸送体GLUT12/SLC2A12　種差を考慮した研究デザインによるアンサングトランスポーターの発見2021
- Author(s)
  高田龍平、宮田大資、豊田優、鈴木洋史
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K15293
[Presentation] Functional Cooperation of Physiological Urate Transporters and Their Modification by Food Components2020
- Author(s)
  Takada Tappei, Toyoda Yu, Miyata Hiroshi, Satsu Hideo, Matsuo Hirotaka, Ichida Kimiyoshi, Suzuki Hiroshi
- Organizer
  JAACT2020 Fuchu
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23793
[Presentation] ABCG2, a physiologically and pharmacologically important exporter in humans2020
- Author(s)
  Tappei Takada, Yu Toyoda, Hiroshi Miyata, Hirotaka Matsuo, Kimiyoshi Ichida, Hiroshi Suzuki
- Organizer
  8th FEBS Special Meeting: ABC Proteins : From Multidrug Resistance to Genetic Disease, Innsbruck, Austria.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23793
[Presentation] ABCG2 is a physiological exporter of indoxyl sulfate, and its dysfunction accelerates the progression of chronic kidney disease2020
- Author(s)
  Yamamoto Takehito , Takada Tappei, Tan Jeng Kae, Miyata Hiroshi, Yamanashi Yoshihide, Toyoda Yu, Suzuki Hiroshi
- Organizer
  FIP PSWC 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23793
[Presentation] ゲノム解析により見出された尿酸トランスポーターと尿酸降下薬に関する研究2020
- Author(s)
  高田龍平、宮田大資、豊田優、鈴木洋史
- Organizer
  第30回日本医療薬学会年会
- Data Source
  KAKENHI-PROJECT-19K23793
[Presentation] GLUT12/SLC2A12は血清尿酸値を制御する尿酸輸送体である2020
- Author(s)
  宮田大資、高田龍平、豊田優、鈴木洋史
- Organizer
  第5回トランスポーター研究会関東部会
- Data Source
  KAKENHI-PROJECT-19K23793
[Presentation] 尿酸排出トランスポーターABCG2に関する生理学的・薬理学的研究2019
- Author(s)
  高田龍平、宮田大資、豊田優、山梨義英、山本武人、鈴木洋史
- Organizer
  生理研研究会『上皮膜・間質の機能連関と病態発現機構解明のためのストラテジー』　岡崎
- Data Source
  KAKENHI-PROJECT-19K23793
[Presentation] 腸管・腎尿細管の尿酸輸送と高尿酸血症2019
- Author(s)
  高田龍平、宮田大資、豊田優、山梨義英、山本武人、鈴木洋史
- Organizer
  第50回日本消化吸収学会総会　羽田
- Data Source
  KAKENHI-PROJECT-19K23793
[]

1. Matsuo Hirotaka (00528292)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 豊田優 (80650340)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 関根舞 (40881496)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 大橋勇紀 (60980852)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 高田龍平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 葛西秀俊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MIYATA Hiroshi 宮田 大資

Research Projects

Research Products

Co-Researchers

血清尿酸値が抗がん剤の副作用に与える影響の検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

An international (Japan-USA-Vietnam) collaborative research for molecular genetic epidemiology in urate-related diseases including gout and hyperuricemia

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the clinical significance of drug interactions mediated by ABCG2 inhibition on hematopoietic stem cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

International collaborative study on the genetic factors that regulate serum urate levels in humans: clinico-genetic analyses and functional studies focusing on urate transporters

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Impact of a novel urate transporter on the regulation of the blood urate level.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Membrane Transporter (s)–mediated Regulation of Urate and Vitamin C Behavior in the Body2024

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] SVCT2/SLC23A2 is a sodium-dependent urate transporter: functional properties and practical application.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Elevation of tacrolimus concentration after administration of methotrexate for treatment of graft-versus-host disease in pediatric patients received allogeneic hematopoietic stem cell transplantation2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Recent Advances in Research on Vitamin C Transporters2023

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Identification of an exporter that regulates vitamin C supply from blood to the brain2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] GLUT12の生理的重要性－尿酸の体内動態制御および脳へのビタミンC供給の観点から.2022

Author(s)

Journal Title

Data Source

[Journal Article] 近年明らかになってきた血清尿酸値を規定する尿酸トランスポーター2022

Author(s)

Journal Title

Data Source

[Journal Article] 尿酸トランスポーター：ABCG2/BCRPに関する最近の知見と近年の尿酸トランスポーター研究の進展について2021

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Identification of GLUT12/SLC2A12 as a urate transporter that regulates the blood urate level in hyperuricemia model mice.2020

Author(s)

Journal Title

DOI

MIYATA Hiroshi 宮田大資

[Presentation] 膜輸送体研究の方法～巨人の肩に立ち、輸送体の囁きを聴く～　新規尿酸輸送体GLUT12/SLC2A12　種差を考慮した研究デザインによるアンサングトランスポーターの発見2021