Vinogradov Alexander VINOGRADOV Alexander

Researcher Number	90845819
Affiliation (based on the past Project Information) *help	2024: 東京大学, 大学院理学系研究科(理学部), 准教授 2020 – 2023: 東京大学, 大学院理学系研究科(理学部), 特任助教
Review Section/Research Field	Principal Investigator Basic Section 37030:Chemical biology-related / Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
Keywords	Principal Investigator mRNA display / Enzymes / Machine learning / in vitro translation / Phospho-amino acids / Lysine labeling / enzyme PTM / Lysine labelling / Deep learning / deep learning … More / enzymes / PTM / Combinatorial synthesis / Thiopeptides / Natural products / Biochemistry / Bioengineering / Biosynthesis Less

Accurate analysis of PTM enzymes with an mRNA display/deep learning platformPrincipal Investigator
- Principal Investigator
  
  Vinogradov Alexander
- Project Period (FY)
  2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  The University of Tokyo
Characterization of novel biosynthetic gene clusters for combinatorial synthesis of thiopeptidesPrincipal Investigator
- Principal Investigator
  
  Vinogradov Alexander
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  The University of Tokyo

All 2025 2024 2021 2020

All Journal Article Presentation

[Journal Article] Ligand-Enabled Selective Coupling of MIDA Boronates to Dehydroalanine-Containing Peptides and Proteins2025
- Author(s)
  Vinogradov Alexander A.、Pan Shih-Yu、Suga Hiroaki
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 147 Issue: 9 Pages: 7533-7544
- DOI
  10.1021/jacs.4c16525
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23485
[Journal Article] Illuminating Substrate Preferences of Promiscuous F<sub>420</sub>H<sub>2</sub>-Dependent Dehydroamino Acid Reductases with 4-Track mRNA Display2024
- Author(s)
  Vinogradov Alexander A.、Bashiri Ghader、Suga Hiroaki
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 146 Issue: 45 Pages: 31124-31136
- DOI
  10.1021/jacs.4c11013
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23485
[Journal Article] Selective pH-Responsive Conjugation between a Pair of De Novo Discovered Peptides2024
- Author(s)
  Ohno Yuto、Vinogradov Alexander A.、Suga Hiroaki
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 146 Issue: 43 Pages: 29429-29440
- DOI
  10.1021/jacs.4c08520
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23485
[Journal Article] A Compact Reprogrammed Genetic Code for De Novo Discovery of Proteolytically Stable Thiopeptides2024
- Author(s)
  Vinogradov Alexander A.、Zhang Yue、Hamada Keisuke、Kobayashi Shunsuke、Ogata Kazuhiro、Sengoku Toru、Goto Yuki、Suga Hiroaki
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 146 Issue: 12 Pages: 8058-8070
- DOI
  10.1021/jacs.3c12037
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-21H05158, KAKENHI-PLANNED-21H05161, KAKENHI-PROJECT-20H05618, KAKENHI-PROJECT-23K23485, KAKENHI-PROJECT-21K06051, KAKENHI-PROJECT-22KF0114, KAKENHI-PROJECT-24K09355
[Journal Article] Site-Specific Nonenzymatic Peptide S/O-Glutamylation Reveals the Extent of Substrate Promiscuity in Glutamate Elimination Domains2021
- Author(s)
  Alexander A. Vinogradov, Masanobu Nagano, Yuki Goto, and Hiroaki Suga
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 143 Issue: 33 Pages: 13358-13369
- DOI
  10.1021/jacs.1c06470
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15407, KAKENHI-PROJECT-19K22243, KAKENHI-PROJECT-20H02866
[Journal Article] Accurate Broadcasting of Substrate Fitness for Lactazole Biosynthetic Pathway from Reactivity-Profiling mRNA Display2020
- Author(s)
  Vinogradov Alexander A.、Nagai Emiko、Chang Jun Shi、Narumi Kakeru、Onaka Hiroyasu、Goto Yuki、Suga Hiroaki
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 142 Issue: 48 Pages: 20329-20334
- DOI
  10.1021/jacs.0c10374
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H05618, KAKENHI-PROJECT-19K22243, KAKENHI-PROJECT-20K15407, KAKENHI-PROJECT-20H02866
[Presentation] Comprehensive analysis of substrate preferences of RiPP enzymes using mRNA display and deep learning2024
- Author(s)
  Alexander Vinogradov and Hiroaki Suga
- Organizer
  The 2nd International Conference on RiPPs (RiPPs2024)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23485
[Presentation] De novo discovery of natural product-like thiopeptides with designed biological activities2024
- Author(s)
  Vinogradov Alexander
- Organizer
  36th Irsee Natural Product Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23485
[Presentation] De novo discovery of natural product-like thiopeptides with designed biological activities2024
- Author(s)
  Alexander Vinogradov; Yue Zhang; Yuki Goto; Hiroaki Suga
- Organizer
  36th Irsee Natural Product Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23485
[Presentation] De novo discovery of natural product-like thiopeptides with designed biological activities2024
- Author(s)
  Vinogradov Alexander
- Organizer
  TIDES Asia 2024
- Invited
- Data Source
  KAKENHI-PROJECT-23K23485
[Presentation] De novo discovery of natural product-like thiopeptides with designed biological activities2024
- Author(s)
  Alexander Vinogradov and Hiroaki Suga
- Organizer
  TIDES Asia 2024
- Invited
- Data Source
  KAKENHI-PROJECT-23K23485

1. SUGA Hiroaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 二村圭祐

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 仙石徹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Vinogradov Alexander VINOGRADOV Alexander

Research Projects

Research Products

Co-Researchers

Accurate analysis of PTM enzymes with an mRNA display/deep learning platformPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Characterization of novel biosynthetic gene clusters for combinatorial synthesis of thiopeptidesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Ligand-Enabled Selective Coupling of MIDA Boronates to Dehydroalanine-Containing Peptides and Proteins2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Illuminating Substrate Preferences of Promiscuous F<sub>420</sub>H<sub>2</sub>-Dependent Dehydroamino Acid Reductases with 4-Track mRNA Display2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Selective pH-Responsive Conjugation between a Pair of De Novo Discovered Peptides2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Compact Reprogrammed Genetic Code for De Novo Discovery of Proteolytically Stable Thiopeptides2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Site-Specific Nonenzymatic Peptide S/O-Glutamylation Reveals the Extent of Substrate Promiscuity in Glutamate Elimination Domains2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Accurate Broadcasting of Substrate Fitness for Lactazole Biosynthetic Pathway from Reactivity-Profiling mRNA Display2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] Comprehensive analysis of substrate preferences of RiPP enzymes using mRNA display and deep learning2024

Author(s)

Organizer

Data Source

[Presentation] De novo discovery of natural product-like thiopeptides with designed biological activities2024

Author(s)

Organizer

Data Source

[Presentation] De novo discovery of natural product-like thiopeptides with designed biological activities2024

Author(s)

Organizer

Data Source

[Presentation] De novo discovery of natural product-like thiopeptides with designed biological activities2024

Author(s)

Organizer

Data Source

[Presentation] De novo discovery of natural product-like thiopeptides with designed biological activities2024

Author(s)

Organizer

Data Source