IGUCHI TOMOKI 井口巴樹

… Alternative Names

井口巴樹イグチトモキ

Iguchi Tomoki 井口巴樹

Less

Researcher Number	90847120
Other IDs	https://orcid.org/0000-0003-0337-9776
Affiliation (Current)	2025: 東京薬科大学, 薬学部, 助教
Affiliation (based on the past Project Information) *help	2025: 東京薬科大学, 薬学部, 助教 2022 – 2023: 東京薬科大学, 薬学部, 助教 2019 – 2020: 東京薬科大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 47050:Environmental and natural pharmaceutical resources-related / 0801:Pharmaceutical sciences and related fields Except Principal Investigator Basic Section 47050:Environmental and natural pharmaceutical resources-related
Keywords	Principal Investigator 天然物 / がん / アポトーシス / ステロイド配糖体 / フェロトーシス / サポニン / 非内因性経路 / 小細胞肺がん / 構造決定 / アポトーシス誘導活性 … More / 腫瘍細胞毒性 / トリテルペン配糖体 / Allium atropurpureum / ‘Globemaster’ / Saponaria officinalis / 腫瘍細胞 / ミトコンドリア / ミトコンドリア非依存的 … More Except Principal Investigator 併用効果 / 特定外来植物 / 抗がん剤 / PARP阻害薬シーズ / 細胞毒性 / トリテルペン配糖体 / トリテルペン / 構造決定 / ナガエツルノゲイトウ / 特定外来生物 / 天然物 / PARP阻害活性 Less

新規がん治療薬リードの創出を志向した天然物由来フェロトーシス誘導化合物の探索Principal Investigator
- Principal Investigator
  
  井口巴樹
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
Search for new seeds of anti-cancer agents targeting PARP from natural products
- Principal Investigator
  
  三巻祥浩
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
非内因性経路に着目した植物由来サポニンのアポトーシス誘導メカニズムの解明Principal Investigator
- Principal Investigator
  
  井口巴樹
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
Elucidation of induction of apoptosis by steroidal glycosides via a mitochondria-independent pathwayPrincipal Investigator
- Principal Investigator
  
  Iguchi Tomoki
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0801:Pharmaceutical sciences and related fields
- Research Institution
  Tokyo University of Pharmacy and Life Science

All 2024 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Steroidal glycosides from Ornithogalum thyrsoides bulbs and their cytotoxicity toward HL-60 human promyelocytic leukemia cells and SBC-3 human small-cell lung cancer cells2024
- Author(s)
  Shimazaki Tamami、Iguchi Tomoki、Takahashi Naoki、Sano Yukako、Nakamura Kaito、Mimaki Yoshihiro
- Journal Title
  
  Phytochemistry
  
  Volume: 219 Pages: 113985-113985
- DOI
  10.1016/j.phytochem.2024.113985
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15306
[Journal Article] 特定外来生物ナガエツルノゲイトウAlternanthera philoxeroides地下部から単離されたトリテルペン配糖体とそれらの腫瘍細胞毒性2024
- Author(s)
  松尾侑希子、井口巴樹、黒田明平、三宅克典、加藤宏直、木村優花、三巻祥浩
- Journal Title
  
  生薬学雑誌
  
  Volume: 78 Pages: 109-114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K06199
[Journal Article] Structure elucidation of 16 undescribed steroidal glycosides from the underground parts of Agapanthus africanus and apoptosis-inducing activity in small-cell lung cancer cell2023
- Author(s)
  Takahashi N., Iguchi T., Nagamine A., Shirai R., Nagata A., Yamauchi J., Mimaki Y.
- Journal Title
  
  ACS Omega
  
  Volume: 8 Issue: 2 Pages: 2808-2830
- DOI
  10.1021/acsomega.2c07766
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15306
[Journal Article] Determination of Structure and Cytotoxicity of Ten Undescribed Steroidal Glycosides from Allium cristophii × A. macleanii ‘Globemaster’2023
- Author(s)
  Shimazaki Tamami、Iguchi Tomoki、Takahashi Yuna、Yamamoto Kie、Takahashi Naoki、Mimaki Yoshihiro
- Journal Title
  
  Molecules
  
  Volume: 28 Issue: 17 Pages: 6248-6248
- DOI
  10.3390/molecules28176248
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15306
[Journal Article] Six unprecedented steroidal glycosides from Allium atropurpureum bulbs and their cytotoxicities against SBC-3 human small-cell lung cancer cells2023
- Author(s)
  Shimazaki Tamami、Iguchi Tomoki、Kanda Aki、Yamamoto Kie、Takahashi Naoki、Mimaki Yoshihiro
- Journal Title
  
  Phytochemistry Letters
  
  Volume: 57 Pages: 200-209
- DOI
  10.1016/j.phytol.2023.08.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15306
[Journal Article] Novel Oleanane-Type Triterpene Glycosides from the Saponaria officinalis L. Seeds and Apoptosis-Inducing Activity via Mitochondria2022
- Author(s)
  Takahashi N., Iguchi T., Kuroda M., Mishima M., Mimaki Y.
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 23 Issue: 4 Pages: 2047-2047
- DOI
  10.3390/ijms23042047
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15306
[Journal Article] Phenolic compounds from the underground parts of Eremurus robustus and their cytotoxicity2022
- Author(s)
  Iguchi T., Kuroda M., Morita H., Mimaki Y.
- Journal Title
  
  Jpn. J. Pharmacog.
  
  Volume: 76 Pages: 45-46
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15306
[Journal Article] Three novel furospirostanol glycosides and a steroidal alkaloid glycoside from the bulbs of Fritillaria camtschatcensis (L.) Ker Gawl., and their cytotoxicity2021
- Author(s)
  Iguchi Tomoki、Kuroda Minpei、Takayama Hiroshi、Mimaki Yoshihiro
- Journal Title
  
  Natural Product Research
  
  Volume: - Issue: 15 Pages: 1-7
- DOI
  10.1080/14786419.2021.1897590
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K23809
[Journal Article] A Total of Eight Novel Steroidal Glycosides Based on Spirostan, Furostan, Pseudofurostan, and Cholestane from the Leaves of Cestrum newellii2020
- Author(s)
  Iguchi Tomoki、Takahashi Naoki、Mimaki Yoshihiro
- Journal Title
  
  Molecules
  
  Volume: 25 Issue: 19 Pages: 4462-4475
- DOI
  10.3390/molecules25194462
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K23809
[Presentation] ユリ科 Ornithogalum thyrsoides 鱗茎から単離された新規コレスタン型ステロイド配糖体の化学構造と腫瘍細胞毒性2023
- Author(s)
  高橋直熙, 井口巴樹, 中村凱士, 佐野友佳子, 三巻祥浩
- Organizer
  日本生薬学会第69回年会
- Data Source
  KAKENHI-PROJECT-22K15306
[Presentation] Ornithogalum thyrsoides鱗茎から単離された21種の新規ステロイド配糖体の構造と腫瘍細胞毒性2023
- Author(s)
  井口巴樹、高橋直熙、島﨑珠美、中村凱士、佐野友佳子、三巻祥浩
- Organizer
  第24回天然薬物の開発と応用シンポジウム
- Data Source
  KAKENHI-PROJECT-23K06199
[Presentation] ユリ科Ornithogalum thyrsoides鱗茎から単離された新規コレスタン型ステロイド配糖体の化学構造と腫瘍細胞毒性2023
- Author(s)
  高橋直熙、井口巴樹、中村凱士、佐野友佳子、三巻祥浩
- Organizer
  日本生薬学会第69回年会
- Data Source
  KAKENHI-PROJECT-23K06199
[Presentation] ユリ科 Allium atropurpureum 鱗茎から単離されたステロイド配糖体の化学構造と腫瘍細胞毒性2023
- Author(s)
  島﨑珠美, 井口巴樹, 神田明紀, 山本貴恵, 高橋直煕, 三巻祥浩
- Organizer
  日本生薬学会第69回年会
- Data Source
  KAKENHI-PROJECT-22K15306
[Presentation] Ornithogalum thyrsoides鱗茎から単離された21種の新規ステロイド配糖体の構造と腫瘍細胞毒性2023
- Author(s)
  井口巴樹，高橋直熙，島﨑珠美，中村凱士，佐野友佳子，三巻祥浩
- Organizer
  第24回天然薬物の開発と応用シンポジウム
- Data Source
  KAKENHI-PROJECT-22K15306
[Presentation] ユリ科 Agapanthus africanus 地下部から単離された新規ステロイド配糖体の構造と SBC-3 ヒト小細胞肺がん細胞に対するアポトーシス誘導活性2022
- Author(s)
  高橋直熙，井口巴樹，永峯杏樹，横須賀章人，三巻祥浩
- Organizer
  日本生薬学会第68回年会
- Data Source
  KAKENHI-PROJECT-22K15306

1. 三巻祥浩 (90229790)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. 松尾侑希子 (70434016)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

IGUCHI TOMOKI 井口 巴樹

井口 巴樹 イグチ トモキ

Iguchi Tomoki 井口 巴樹

Research Projects

Research Products

Co-Researchers

新規がん治療薬リードの創出を志向した天然物由来フェロトーシス誘導化合物の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Search for new seeds of anti-cancer agents targeting PARP from natural products

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

非内因性経路に着目した植物由来サポニンのアポトーシス誘導メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of induction of apoptosis by steroidal glycosides via a mitochondria-independent pathwayPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Steroidal glycosides from Ornithogalum thyrsoides bulbs and their cytotoxicity toward HL-60 human promyelocytic leukemia cells and SBC-3 human small-cell lung cancer cells2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 特定外来生物ナガエツルノゲイトウAlternanthera philoxeroides地下部から単離されたトリテルペン配糖体とそれらの腫瘍細胞毒性2024

Author(s)

Journal Title

Data Source

[Journal Article] Structure elucidation of 16 undescribed steroidal glycosides from the underground parts of Agapanthus africanus and apoptosis-inducing activity in small-cell lung cancer cell2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Determination of Structure and Cytotoxicity of Ten Undescribed Steroidal Glycosides from Allium cristophii × A. macleanii ‘Globemaster’2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Six unprecedented steroidal glycosides from Allium atropurpureum bulbs and their cytotoxicities against SBC-3 human small-cell lung cancer cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Novel Oleanane-Type Triterpene Glycosides from the Saponaria officinalis L. Seeds and Apoptosis-Inducing Activity via Mitochondria2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phenolic compounds from the underground parts of Eremurus robustus and their cytotoxicity2022

Author(s)

Journal Title

Data Source

[Journal Article] Three novel furospirostanol glycosides and a steroidal alkaloid glycoside from the bulbs of Fritillaria camtschatcensis (L.) Ker Gawl., and their cytotoxicity2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Total of Eight Novel Steroidal Glycosides Based on Spirostan, Furostan, Pseudofurostan, and Cholestane from the Leaves of Cestrum newellii2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] ユリ科 Ornithogalum thyrsoides 鱗茎から単離された新規コレスタン型ステロイ ド配糖体の化学構造と腫瘍細胞毒性2023

Author(s)

Organizer

Data Source

[Presentation] Ornithogalum thyrsoides鱗茎から単離された21種の新規ステロイド配糖体の構造と腫瘍細胞毒性2023

Author(s)

Organizer

IGUCHI TOMOKI 井口巴樹

井口巴樹イグチトモキ

Iguchi Tomoki 井口巴樹

[Presentation] ユリ科 Ornithogalum thyrsoides 鱗茎から単離された新規コレスタン型ステロイド配糖体の化学構造と腫瘍細胞毒性2023

[Presentation] ユリ科 Allium atropurpureum 鱗茎から単離されたステロイド配糖体の化学構造と腫瘍細胞毒性2023

[Presentation] ユリ科 Agapanthus africanus 地下部から単離された新規ステロイド配糖体の構造と SBC-3 ヒト小細胞肺がん細胞に対するアポトーシス誘導活性2022