Kanno Toshio 菅野敏生

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KANNO TOSHIO 菅野敏生

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Researcher Number	90849291
Other IDs	https://orcid.org/0000-0002-7586-8723
Affiliation (Current)	2026: 公益財団法人かずさDNA研究所, 先端研究開発部, 研究員
Affiliation (based on the past Project Information) *help	2026: 公益財団法人かずさDNA研究所, 先端研究開発部, 研究員 2023 – 2024: 公益財団法人かずさDNA研究所, 先端研究開発部, 研究員 2022: 公益財団法人かずさDNA研究所, 先端研究開発部, 特任研究員 2021: 公益財団法人かずさDNA研究所, 先端研究開発部, 特別研究員
Review Section/Research Field	Principal Investigator Basic Section 49070:Immunology-related
Keywords	Principal Investigator 免疫 / T細胞 / 脂質合成 / cGAS-STING / インフルエンザウイルス / STING / 抗ウイルス応答 / 脂質代謝 / ウイルス / 脂肪酸 … More / 免疫学 / cGAMP / SCD2 / CD4 T細胞 Less

免疫-脂質代謝-自己核酸を基軸とした新規抗ウイルス制御機構Principal Investigator
- Principal Investigator
  
  菅野敏生
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Kazusa DNA Research Institute
Development of a novel strategy for regulating antiviral immune responses based on the immunity-lipid metabolism-virus.Principal Investigator
- Principal Investigator
  
  KANNO TOSHIO
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Kazusa DNA Research Institute
A T cell-specific lipid switch system regulates the activity of pathogen sensor STINGPrincipal Investigator
- Principal Investigator
  
  KANNO TOSHIO
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Kazusa DNA Research Institute

All 2024 2023 2022 2021

All Journal Article Presentation

[Journal Article] IL-27 regulates the differentiation of follicular helper NKT cells via metabolic adaptation of mitochondria2024
- Author(s)
  Kamii Yasuhiro、Hayashizaki Koji、Kanno Toshio、Chiba Akio、Ikegami Taku、Saito Mitsuru、Akeda Yukihiro、Ohteki Toshiaki、Kubo Masato、Yoshida Kiyotsugu、Kawakami Kazuyoshi、Oishi Kazunori、Araya Jun、Kuwano Kazuyoshi、Kronenberg Mitchell、Endo Yusuke、Kinjo Yuki
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 121 Issue: 9
- DOI
  10.1073/pnas.2313964121
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K14552, KAKENHI-PROJECT-21K07085, KAKENHI-PUBLICLY-23H04794, KAKENHI-PROJECT-20H03455, KAKENHI-PROJECT-23K24382, KAKENHI-PROJECT-24K02246, KAKENHI-PROJECT-24K22064
[Journal Article] Fatty acid metabolism constrains Th9 cell differentiation and antitumor immunity via the modulation of retinoic acid receptor signaling2024
- Author(s)
  Nakajima Takahiro、Kanno Toshio、Ueda Yuki、Miyako Keisuke、Endo Takeru、Yoshida Souta、Yokoyama Satoru、Asou Hikari K.、Yamada Kazuko、Ikeda Kazutaka、Togashi Yosuke、Endo Yusuke
- Journal Title
  
  Cellular & Molecular Immunology
  
  Volume: 21 Issue: 11 Pages: 1266-1281
- DOI
  10.1038/s41423-024-01209-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-23H04794, KAKENHI-PROJECT-23K14552, KAKENHI-PROJECT-24K02246, KAKENHI-PROJECT-24K02459, KAKENHI-PROJECT-24K11153, KAKENHI-PROJECT-24K22064, KAKENHI-PROJECT-24K22071, KAKENHI-PROJECT-23KK0149
[Journal Article] The integration of metabolic and proteomic data uncovers an augmentation of the sphingolipid biosynthesis pathway during T-cell differentiation2024
- Author(s)
  Kanno Toshio、Konno Ryo、Sato Masaru、Kurabayashi Atsushi、Miyako Keisuke、Nakajima Takahiro、Yokoyama Satoru、Sasamoto Shigemi、Asou Hikari K.、Ohzeki Junichiro、Hasegawa Yoshinori、Ikeda Kazutaka、Kawashima Yusuke、Ohara Osamu、Endo Yusuke
- Journal Title
  
  Communications Biology
  
  Volume: 7 Issue: 1 Pages: 622-622
- DOI
  10.1038/s42003-024-06339-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-23H04794, KAKENHI-PROJECT-23K14552, KAKENHI-PROJECT-24K02246, KAKENHI-PROJECT-24K22064
[Journal Article] Lipid metabolism: a central modulator of RORγt-mediated Th17 cell differentiation2024
- Author(s)
  Kanno Toshio、Miyako Keisuke、Endo Yusuke
- Journal Title
  
  International Immunology
  
  Volume: 36 Issue: 10 Pages: 487-496
- DOI
  10.1093/intimm/dxae031
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-23H04794, KAKENHI-PROJECT-23K14552, KAKENHI-PROJECT-24K02246, KAKENHI-PROJECT-24K22064
[Journal Article] Lipid metabolism in Th17 cell function2023
- Author(s)
  Kanno Toshio、Nakajima Takahiro、Miyako Keisuke、Endo Yusuke
- Journal Title
  
  Pharmacology & Therapeutics
  
  Volume: 245 Pages: 108411-108411
- DOI
  10.1016/j.pharmthera.2023.108411
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K20766, KAKENHI-PROJECT-23K14552, KAKENHI-PROJECT-22K15502, KAKENHI-PUBLICLY-23H04794, KAKENHI-PROJECT-20H03455
[Journal Article] ACC1-mediated fatty acid biosynthesis intrinsically controls thymic iNKT cell development2023
- Author(s)
  Kanno Toshio、Miyako Keisuke、Endo Takeru、Yokoyama Satoru、Asou Hikari K、Yamada Kazuko、Ohara Osamu、Nakayama Toshinori、Kimura Motoko Y、Endo Yusuke
- Journal Title
  
  International Immunology
  
  Volume: 36 Issue: 3 Pages: 129-139
- DOI
  10.1093/intimm/dxad049
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K14552, KAKENHI-PLANNED-22H05189, KAKENHI-PUBLICLY-23H04794, KAKENHI-PROJECT-20H03455, KAKENHI-PROJECT-24K02246, KAKENHI-PROJECT-24K22064
[Journal Article] 1-Oleoyl-lysophosphatidylethanolamine stimulates RORγt activity in T <sub>H</sub> 17 cells2023
- Author(s)
  Endo Yusuke、Kanno Toshio、Nakajima Takahiro、Ikeda Kazutaka、Taketomi Yoshitaka、Yokoyama Satoru、Sasamoto Shigemi、Asou Hikari K.、Miyako Keisuke、Hasegawa Yoshinori、Kawashima Yusuke、Ohara Osamu、Murakami Makoto、Nakayama Toshinori
- Journal Title
  
  Science Immunology
  
  Volume: 8 Issue: 86
- DOI
  10.1126/sciimmunol.add4346
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14552, KAKENHI-PROJECT-22K15502, KAKENHI-PROJECT-20H05691, KAKENHI-PUBLICLY-23H04794, KAKENHI-PROJECT-20H03455, KAKENHI-PROJECT-19H05650
[Journal Article] SCD2-mediated cooperative activation of IRF3-IRF9 regulatory circuit controls type I interferon transcriptome in CD4+ T cells2022
- Author(s)
  Kanno Toshio、Miyako Keisuke、Nakajima Takahiro、Yokoyama Satoru、Sasamoto Shigemi、Asou Hikari K.、Ohara Osamu、Nakayama Toshinori、Endo Yusuke
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 13 Pages: 904875-904875
- DOI
  10.3389/fimmu.2022.904875
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-20H03455, KAKENHI-PROJECT-21K15476, KAKENHI-PROJECT-21K20766
[Journal Article] SCD2-mediated monounsaturated fatty acid metabolism regulates cGAS-STING-dependent type I IFN responses in CD4+ T cells2021
- Author(s)
  Kanno Toshio、Nakajima Takahiro、Yokoyama Satoru、Asou Hikari K.、Sasamoto Shigemi、Kamii Yasuhiro、Hayashizaki Koji、Ouchi Yasuo、Onodera Taishi、Takahashi Yoshimasa、Ikeda Kazutaka、Hasegawa Yoshinori、Kinjo Yuki、Ohara Osamu、Nakayama Toshinori、Endo Yusuke
- Journal Title
  
  Communications Biology
  
  Volume: 4(1) Issue: 1 Pages: 820-820
- DOI
  10.1038/s42003-021-02310-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20383, KAKENHI-PROJECT-20K21618, KAKENHI-PROJECT-19K16704, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-20H03455, KAKENHI-PROJECT-21K07085, KAKENHI-PROJECT-21K15476, KAKENHI-PROJECT-19H03705, KAKENHI-PROJECT-17KK0189, KAKENHI-PROJECT-20K07651
[Presentation] Th9細胞の脂肪酸代謝制御による抗腫瘍活性の誘導2024
- Author(s)
  菅野敏生
- Organizer
  第10回がんと代謝研究会
- Data Source
  KAKENHI-PROJECT-23K14552
[Presentation] Inhibition of ACC1-dependent de novo fatty acid biosynthesis augments Th9 differentiation and anti-tumor immunity2024
- Author(s)
  菅野敏生
- Organizer
  第53回日本免疫学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K14552
[Presentation] 脂質代謝経路に着目をした胸腺T細胞のオミックス解析2024
- Author(s)
  菅野敏生
- Organizer
  2024 Kyoto T cell conference
- Data Source
  KAKENHI-PROJECT-23K14552
[Presentation] SCD2による脂質代謝の抑制は、抗ウイルス反応を誘導する2024
- Author(s)
  菅野敏生
- Organizer
  第52回免疫学会学術集 2024年1月18日中山俊憲
- Data Source
  KAKENHI-PROJECT-23K14552
[Presentation] 活性化CD4 T細胞サブセットでの細胞内代謝経路に着目をした網羅的なオミックス解析の研究2023
- Author(s)
  菅野敏生
- Organizer
  第65回日本脂質生化学会 2023年6月9日
- Data Source
  KAKENHI-PROJECT-23K14552
[Presentation] 病原体センサーSTING活性を誘導する脂質代謝経路の解明2022
- Author(s)
  菅野敏生
- Organizer
  第31回 Kyoto T Cell Conference (KTCC), 2022年
- Data Source
  KAKENHI-PROJECT-21K15476
[Presentation] SCD2-mediated cooperative activation of IRF3-IRF9 regulatory circuit controls type I interferon transcriptome in CD4+ T cells2022
- Author(s)
  菅野敏生
- Organizer
  第51回　日本免疫学会学術集会,2022年
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15476
[Presentation] SCD2-mediated monounsaturated fatty acid metabolism regulates cGAS-STING-dependent type I IFN responses in CD4+ T cells2021
- Author(s)
  菅野敏生
- Organizer
  第50回　日本免疫学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15476

1. 中山俊憲

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
2. 中嶋隆裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 遠藤裕介

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

Kanno Toshio 菅野 敏生

KANNO TOSHIO 菅野 敏生

Research Projects

Research Products

Co-Researchers

免疫-脂質代謝-自己核酸を基軸とした新規抗ウイルス制御機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a novel strategy for regulating antiviral immune responses based on the immunity-lipid metabolism-virus.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A T cell-specific lipid switch system regulates the activity of pathogen sensor STINGPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] IL-27 regulates the differentiation of follicular helper NKT cells via metabolic adaptation of mitochondria2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fatty acid metabolism constrains Th9 cell differentiation and antitumor immunity via the modulation of retinoic acid receptor signaling2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The integration of metabolic and proteomic data uncovers an augmentation of the sphingolipid biosynthesis pathway during T-cell differentiation2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lipid metabolism: a central modulator of RORγt-mediated Th17 cell differentiation2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lipid metabolism in Th17 cell function2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ACC1-mediated fatty acid biosynthesis intrinsically controls thymic iNKT cell development2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 1-Oleoyl-lysophosphatidylethanolamine stimulates RORγt activity in T <sub>H</sub> 17 cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] SCD2-mediated cooperative activation of IRF3-IRF9 regulatory circuit controls type I interferon transcriptome in CD4+ T cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] SCD2-mediated monounsaturated fatty acid metabolism regulates cGAS-STING-dependent type I IFN responses in CD4+ T cells2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] Th9細胞の脂肪酸代謝制御による抗腫瘍活性の誘導2024

Author(s)

Organizer

Data Source

[Presentation] Inhibition of ACC1-dependent de novo fatty acid biosynthesis augments Th9 differentiation and anti-tumor immunity2024

Author(s)

Organizer

Data Source

[Presentation] 脂質代謝経路に着目をした胸腺T細胞のオミックス解析2024

Author(s)

Organizer

Data Source

Kanno Toshio 菅野敏生

KANNO TOSHIO 菅野敏生