Kakumoto Toshiyuki 角元利行

Researcher Number	90876814
Other IDs	https://orcid.org/0000-0002-1147-9454
Affiliation (Current)	2026: 東京大学, 医学部附属病院, 講師
Affiliation (based on the past Project Information) *help	2024: 東京大学, 医学部附属病院, 講師 2022 – 2023: 東京大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 52010:General internal medicine-related Except Principal Investigator Basic Section 52020:Neurology-related / Basic Section 52040:Radiological sciences-related
Keywords	Principal Investigator ELISA / ニューロフィラメント軽鎖 / バイオマーカー / 副腎白質ジストロフィー Except Principal Investigator 細胞モデル / 全ゲノム配列解析 / 神経核内封入体病 / 良性成人型家族性ミオクローヌスてんかん / リピート伸長変異 / リピート伸長病 … More / 軽度認知機能障害 / 脳糖代謝 / 神経核 / マイネルト核 / FDG / 認知症 / アミロイド / PET Less

Research on neurodegenerative disorders
- Principal Investigator
  
  石浦浩之
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Okayama University
Investigation of small nuclei by brain-dedicated PET
- Principal Investigator
  
  高橋美和子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  National Institutes for Quantum Science and Technology
Searching for biomarkers to discriminate the disease forms of adrenoleukodystrophy and to determine the indications for treatmentPrincipal Investigator
- Principal Investigator
  
  Kakumoto Toshiyuki
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  The University of Tokyo

All 2025 2024 2023 2022

All Journal Article Presentation

[Journal Article] In-frame deletion variant of ABCD1 in a sporadic case of adrenoleukodystrophy2025
- Author(s)
  Matsukawa Takashi、Sudo Atsushi、Kakumoto Toshiyuki、Hao Akihito、Kainaga Mitsuhiro、Chang Hyangri、Mano Tatsuo、Ishiura Hiroyuki、Mitsui Jun、Hayashi Toshihiro、Morishita Shinichi、Tsuji Shoji、Toda Tatsushi
- Journal Title
  
  Human Genome Variation
  
  Volume: 12 Issue: 1 Pages: 5-5
- DOI
  10.1038/s41439-025-00309-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07413, KAKENHI-PROJECT-22K07512, KAKENHI-PROJECT-22K07533, KAKENHI-PROJECT-23K18267, KAKENHI-PROJECT-23K27514, KAKENHI-PROJECT-24K18699
[Journal Article] Case of Pure Agraphia in Kana and Romaji Without Sensorimotor Deficits After a Small Infarct of the Posterior Limb of the Internal Capsule2025
- Author(s)
  Katsuse Kazuto、Kubota Akatsuki、Kakinuma Kazuo、Ota Shoko、Kanno Shigenori、Kakumoto Toshiyuki、Shirota Yuichiro、Hamada Masashi、Toda Tatsushi、Suzuki Kyoko
- Journal Title
  
  Neurology
  
  Volume: 104 Issue: 7
- DOI
  10.1212/wnl.0000000000210254
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-20H05956, KAKENHI-PROJECT-23K21847, KAKENHI-PROJECT-20K11202, KAKENHI-PROJECT-22K07413, KAKENHI-PROJECT-23KJ0395, KAKENHI-PROJECT-24K14371
[Journal Article] Frequency of FGF14 Intronic GAA Repeat Expansion in Patients with Multiple System Atrophy and Undiagnosed Ataxia in the Japanese Population.2025
- Author(s)
  Kakumoto T, Orimo K, Matsukawa T, Mitsui J, Ishihara T, Onodera O, Suzuki Y, Morishita S, Japan Multiple System Atrophy Registry Consortium, Toda T, Tsuji S.
- Journal Title
  
  Eur J Hum Genet
  
  Volume: 33 Issue: 3 Pages: 325-333
- DOI
  10.1038/s41431-024-01743-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24085, KAKENHI-PROJECT-22K07413, KAKENHI-PROJECT-23K27514
[Journal Article] Extremely Longitudinally Extensive Transverse Myelitis in a Patient With Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease2024
- Author(s)
  Okubo So、Kakumoto Toshiyuki、Tsujita Masahiko、Muramatsu Kyosuke、Fujiwara Sho、Hamada Masashi、Satake Wataru、Toda Tatsushi
- Journal Title
  
  Cureus
  
  Volume: -
- DOI
  10.7759/cureus.59938
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07413
[Journal Article] A Japanese family with idiopathic basal ganglia calcification carrying a novel XPR1 variant2023
- Author(s)
  Orimo Kenta、Kakumoto Toshiyuki、Hara Ryo、Goto Ryoji、Ishiura Hiroyuki、Mitsui Jun、Yoshida Chiharu、Uesaka Yoshikazu、Suzuki Yuta、Morishita Shinichi、Satake Wataru、Tsuji Shoji、Toda Tatsushi
- Journal Title
  
  Journal of the Neurological Sciences
  
  Volume: 451 Pages: 120732-120732
- DOI
  10.1016/j.jns.2023.120732
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07413, KAKENHI-PROJECT-23K27514
[Journal Article] Long-term survival from progressive multifocal leukoencephalopathy in living-donor liver transplant recipient with preformed donor-specific antibody2023
- Author(s)
  Egashira Shuhei、Kubota Akatsuki、Kakumoto Toshiyuki、Kawasaki Reiko、Kotani Risa、Sakuishi Kaori、Iwata Atsushi、Bae Sung Kwan、Akamatsu Nobuhisa、Hasegawa Kiyoshi、Tanaka Mariko、Nakamichi Kazuo、Saijo Masayuki、Toda Tatsushi
- Journal Title
  
  Journal of NeuroVirology
  
  Volume: 29 Issue: 5 Pages: 519-523
- DOI
  10.1007/s13365-023-01171-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07450, KAKENHI-PROJECT-22K07413
[Journal Article] Copper Deficiency in Wilson's Disease with a Normal Zinc Value2023
- Author(s)
  Ueda Masayuki、Katsuse Kazuto、Kakumoto Toshiyuki、Kobayashi Satoshi、Ishiura Hiroyuki、Mitsui Jun、Toda Tatsushi
- Journal Title
  
  Intern. Med.
  
  Volume: 62 Issue: 7 Pages: 1073-1076
- DOI
  10.2169/internalmedicine.9366-22
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2023-04-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07413, KAKENHI-PROJECT-20H03588
[Journal Article] Neurofilament light chain levels in cerebrospinal fluid as a sensitive biomarker for cerebral adrenoleukodystrophy2023
- Author(s)
  Kakumoto Toshiyuki、Matsukawa Takashi、Ishiura Hiroyuki、Mori Harushi、Tsuji Shoji、Toda Tatsushi
- Journal Title
  
  Annals of Clinical and Translational Neurology
  
  Volume: 10 Issue: 7 Pages: 1230-1238
- DOI
  10.1002/acn3.51818
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07413, KAKENHI-PROJECT-22K07533, KAKENHI-PROJECT-23H00418
[Presentation] FGF14におけるGAAリピート伸長領域のロングリード解析2024
- Author(s)
  角元利行
- Organizer
  日本人類遺伝学会第69回大会
- Data Source
  KAKENHI-PROJECT-22K07413
[Presentation] 脊髄に極長大病変を呈した抗MOG抗体関連疾患の29歳男性2024
- Author(s)
  辻田真比古，村松恭祐，大久保颯，角元利行，濱田雅，佐竹渉，戸田達史
- Organizer
  第248回日本神経学会関東・甲信越地方会
- Data Source
  KAKENHI-PROJECT-22K07413
[Presentation] Exploring HAL Lumbar-Type Exercises in the Rehabilitation of Lower Limb Paralysis due to Myelitis2024
- Author(s)
  Masato Hasegawa, Haruhi Inokuchi, Kazuhiko Yokota, Shoichi Masaki, Takashi Matsukawa, Toshiyuki Kakumoto, Toru Ogata
- Organizer
  The 4th Japan-Taiwan-Korea Neurorehabilitation Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07413
[Presentation] Frequency of FGF14 Intronic GAA Repeat Expansion in Patients with Multiple System Atrophy and Undiagnosed Ataxia in the Japanese Population2024
- Author(s)
  Toshiyuki Kakumoto , Kenta Orimo , Takashi Matsukawa , Jun Mitsui , Yuta Suzuki , Shinichi Morishita , Tatsushi Toda , Shoji Tsuji
- Organizer
  ASHG 2024 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07413
[Presentation] 歩行誘発発作を示す焦点てんかんに対し補足運動野切除が有効であった一例2023
- Author(s)
  小玉聡，代田悠一郎，濱田雅，前田明子，角元利行，國井尚人，嶋田勢二郎，池村雅子，張琢成，河合美津保，上原平，赤松直樹，戸田達史
- Organizer
  第53回日本臨床神経生理学会学術大会
- Data Source
  KAKENHI-PROJECT-22K07413
[Presentation] 小脳・脳幹型副腎白質ジストロフィーの臨床像と造血幹細胞移植(HSCT)による治療効果2023
- Author(s)
  羽尾　曉人、松川　敬志、濱田　雅、角元利行、三井　純、石浦　浩之、辻　省次、戸田　達史
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K07413
[Presentation] 網膜色素変性症と軽度の小脳失調及び脳波異常を認めNeurogenic muscle weakness,ataxia,and retinitis pigmentosa(NARP)と診断した25歳女性例2023
- Author(s)
  横山敬士, 井川彩土, 角元利行, 石浦浩之, 濱田雅, 青木修一郎, 佐竹渉, 戸田達史
- Organizer
  第246回日本神経学会関東・甲信越地方会
- Data Source
  KAKENHI-PROJECT-22K07413
[Presentation] GFAP遺伝子にヘテロ接合性のp.A364T変異を認めた成人型Alexander病の1家系の検討2023
- Author(s)
  中村悠弥子，木村友彦，角元利行，間野達雄，阿部浩幸，松川敬志，濱田雅，戸田達史
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K07413
[Presentation] Neurofilament light chain levels in cerebrospinal fluid is useful for evaluating the disease activities of cerebral adrenoleukodystrophy2023
- Author(s)
  Toshiyuki Kakumoto, Takashi Matsukawa, Hiroyuki Ishiura, Harushi Mori, Shoji Tsuji, Tatsushi Toda
- Organizer
  American Society of Human Genetics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07413
[Presentation] Neurofilament light chain levels in cerebrospinal fluid are markedly increased in cerebral ALD2022
- Author(s)
  Toshiyuki Kakumoto， Takashi Matsukawa， Hiroyuki Ishiura， Harushi Mori， Shoji Tsuji， Tatsushi Toda
- Organizer
  第63 回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K07413
[Presentation] 右内頸動脈起始部高度狭窄により脳梗塞を伴わずに生じた左片側舞踏運動が右頸動脈内膜剥離術で改善した症例2022
- Author(s)
  橋本優子, 原涼, 宮野涼至, 海永光洋, 角元利行, 小泉聡, 宮脇哲, 石浦浩之, 佐竹渉, 戸田達史
- Organizer
  第678回日本内科学会関東地方会
- Data Source
  KAKENHI-PROJECT-22K07413

1. 松川敬志 (80755760)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
2. 高橋美和子 (00529183)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 石浦浩之 (40632849)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. MITSUI Jun

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 中道一生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 鈴木匡子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 辻省次

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kakumoto Toshiyuki 角元 利行

Research Projects

Research Products

Co-Researchers

Research on neurodegenerative disorders

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of small nuclei by brain-dedicated PET

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Searching for biomarkers to discriminate the disease forms of adrenoleukodystrophy and to determine the indications for treatmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] In-frame deletion variant of ABCD1 in a sporadic case of adrenoleukodystrophy2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Case of Pure Agraphia in Kana and Romaji Without Sensorimotor Deficits After a Small Infarct of the Posterior Limb of the Internal Capsule2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Frequency of FGF14 Intronic GAA Repeat Expansion in Patients with Multiple System Atrophy and Undiagnosed Ataxia in the Japanese Population.2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Extremely Longitudinally Extensive Transverse Myelitis in a Patient With Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Japanese family with idiopathic basal ganglia calcification carrying a novel XPR1 variant2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Long-term survival from progressive multifocal leukoencephalopathy in living-donor liver transplant recipient with preformed donor-specific antibody2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Copper Deficiency in Wilson&apos;s Disease with a Normal Zinc Value2023

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Neurofilament light chain levels in cerebrospinal fluid as a sensitive biomarker for cerebral adrenoleukodystrophy2023

Author(s)

Journal Title

DOI

Data Source

[Presentation] FGF14におけるGAAリピート伸長領域のロングリード解析2024

Author(s)

Organizer

Data Source

[Presentation] 脊髄に極長大病変を呈した抗MOG抗体関連疾患の29歳男性2024

Author(s)

Organizer

Data Source

[Presentation] Exploring HAL Lumbar-Type Exercises in the Rehabilitation of Lower Limb Paralysis due to Myelitis2024

Author(s)

Organizer

Data Source

[Presentation] Frequency of FGF14 Intronic GAA Repeat Expansion in Patients with Multiple System Atrophy and Undiagnosed Ataxia in the Japanese Population2024

Author(s)

Organizer

Kakumoto Toshiyuki 角元利行

[Journal Article] Copper Deficiency in Wilson's Disease with a Normal Zinc Value2023