Bo Tomoki 房知輝

… Alternative Names

BO Tomoki 房知輝

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Researcher Number	90878141
Other IDs
Affiliation (Current)	2026: 北海道大学, 獣医学研究院, 講師
Affiliation (based on the past Project Information) *help	2020 – 2024: 山形大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 42020:Veterinary medical science-related / 0901:Oncology and related fields Except Principal Investigator Basic Section 49010:Pathological biochemistry-related
Keywords	Principal Investigator エネルギー代謝 / 放射線 / がん / 分岐鎖アミノ酸 / 中性アミノ酸 / 窒素代謝 / 放射線療法 / 代謝 / LAT1 / 中性アミノ酸代謝 … More Except Principal Investigator … More 細胞死 / ポリアミン / アクロレイン / 一酸化窒素 / マクロファージ Less

Control mechanism of activated macrophages by enhancement of polyamine-acrolein pathway
- Principal Investigator
  
  藤井順逸
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Yamagata University
がん窒素代謝を標的とした新規放射線療法開発のための基盤研究Principal Investigator
- Principal Investigator
  
  房知輝
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Yamagata University
Analysis of neutral amino acid metabolism after X-irradiation and Radio-sensitization by targeting amino acid metabolismPrincipal Investigator
- Principal Investigator
  
  BO TOMOKI
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Yamagata University
LAT1 inhibitor JPH203 sensitizes cancer cells to radiation by enhancing radiation-induced cellular senescencePrincipal Investigator
- Principal Investigator
  
  BO Tomoki
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0901:Oncology and related fields
- Research Institution
  Yamagata University

All 2025 2024 2023 2022 2021

All Journal Article Presentation

[Journal Article] Dephosphorylation of branched-chain α-keto acid dehydrogenase E1α (BCKDHA) promotes branched-chain amino acid catabolism and renders cancer cells resistant to X-rays by mitigating DNA damage2025
- Author(s)
  Bo Tomoki、Osaki Tsukasa、Fujii Junichi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 742 Pages: 151154-151154
- DOI
  10.1016/j.bbrc.2024.151154
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K06410, KAKENHI-PROJECT-24K10074, KAKENHI-PROJECT-24K18014
[Journal Article] Ascorbic Acid Protects Bone Marrow from Oxidative Stress and Transient Elevation of Corticosterone Caused by X-ray Exposure in Akr1a-Knockout Mice2024
- Author(s)
  Bo Tomoki、Nohara Hidekazu、Yamada Ken-ichi、Miyata Satoshi、Fujii Junichi
- Journal Title
  
  Antioxidants
  
  Volume: 13 Issue: 2 Pages: 152-152
- DOI
  10.3390/antiox13020152
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06850, KAKENHI-PROJECT-21K14971, KAKENHI-PUBLICLY-22H05572, KAKENHI-PROJECT-23H05481
[Journal Article] Double-decker cage reduces mount frequency and ejaculation latency, resulting in reduced weight loss in male rats after mating behavior2024
- Author(s)
  Bo Tomoki、Fukuda Naoki、Ozaki Junko、Inoue Ayumi、Katahira Kiyoaki、Ito Tsunekata
- Journal Title
  
  Exp. Anim.
  
  Volume: 73 Issue: 4 Pages: 412-420
- DOI
  10.1538/expanim.24-0026
- ISSN
  0007-5124, 1341-1357, 1881-7122
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24K18014
[Journal Article] Primary Roles of Branched Chain Amino Acids (BCAAs) and Their Metabolism in Physiology and Metabolic Disorders2024
- Author(s)
  Bo Tomoki、Fujii Junichi
- Journal Title
  
  Molecules
  
  Volume: 30 Issue: 1 Pages: 56-56
- DOI
  10.3390/molecules30010056
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24K10074, KAKENHI-PROJECT-24K18014
[Journal Article] Heme Biosynthesis is Crucial for Cell Survival and Mitochondrial OXPHOS after X Irradiation2023
- Author(s)
  Bo Tomoki、Van Wijk Koen、Nakajima Osamu
- Journal Title
  
  Radiation Research
  
  Volume: 201 Issue: 1 Pages: 48-54
- DOI
  10.1667/rade-23-00035.1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K14971
[Journal Article] Ascorbate Is a Primary Antioxidant in Mammals2022
- Author(s)
  Fujii Junichi、Osaki Tsukasa、Bo Tomoki
- Journal Title
  
  Molecules
  
  Volume: 27 Issue: 19 Pages: 6187-6187
- DOI
  10.3390/molecules27196187
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06850, KAKENHI-PROJECT-21K14971
[Journal Article] LAT1 inhibitor JPH203 sensitizes cancer cells to radiation by enhancing radiation-induced cellular senescence2021
- Author(s)
  Bo Tomoki、Kobayashi Sho、Inanami Osamu、Fujii Junichi、Nakajima Osamu、Ito Tsunekata、Yasui Hironobu
- Journal Title
  
  Translational Oncology
  
  Volume: 14 Issue: 11 Pages: 101212-101212
- DOI
  10.1016/j.tranon.2021.101212
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16141, KAKENHI-PROJECT-20K22830, KAKENHI-PROJECT-20H00443, KAKENHI-PROJECT-21K06850, KAKENHI-PROJECT-21K14971, KAKENHI-PROJECT-20KK0250
[Presentation] アスコルビン酸はAkr1a-KOマウスにおけるX線照射による酸化ストレスおよびコルチコステロンの一過性上昇から骨髄細胞を保護する.2024
- Author(s)
  房知輝、野原豪和、山田健一、宮田哲、藤井逸.
- Organizer
  第77回日本酸化ストレス学会
- Data Source
  KAKENHI-PROJECT-24K10074
[Presentation] Akr1a-KOマウスにおけるアスコルビン酸欠乏は酸化ストレスとコルチコステロン上昇によってX線照射後の白血球数回復を遅延させる.2024
- Author(s)
  房知輝、野原豪和、山田健一、宮田哲、藤井順逸.
- Organizer
  第67回日本放射線影響学会大会
- Data Source
  KAKENHI-PROJECT-24K10074
[Presentation] Inhibition of BCAT1 and BCKDHα enhances cancer radiosensitivity.2023
- Author(s)
  Tomoki BO
- Organizer
  日本放射線影響学会第66回大会
- Data Source
  KAKENHI-PROJECT-21K14971
[Presentation] Heme biosynthesis is upregulated to enhance oxidative phosphorylation for cell survival after X-irradiation2023
- Author(s)
  Tomoki BO
- Organizer
  17th International Congress of Radiation Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K14971
[Presentation] The effect of inhibition of heme synthesis on cellular survival and mitochondrial function after X-irradiation2022
- Author(s)
  Tomoki Bo, Koen Van Wijk, Tsunekata Ito, Osamu Nakajima
- Organizer
  日本放射線影響学会第65回大会
- Data Source
  KAKENHI-PROJECT-21K14971
[Presentation] Succinyl acetoneによるヘム生合成阻害はX線照射後のミトコンドリア機能亢進を抑制し放射線誘発細胞死を増強する2022
- Author(s)
  房知輝,Koen Van Wijk,伊藤恒賢,中島修
- Organizer
  第30回山形分子生物学セミナー
- Data Source
  KAKENHI-PROJECT-21K14971
[Presentation] 中性アミノ酸輸送体 LAT1阻害剤 JPH203によるがん放射線増感効果の評価とメカニズムの解明2021
- Author(s)
  房知輝、小林翔、伊藤恒賢、中島修、藤井順逸
- Organizer
  第74回日本酸化ストレス学会/第21回日本NO学会合同学術集会
- Data Source
  KAKENHI-PROJECT-21K14971
[Presentation] 中性アミノ酸輸送体 LAT1阻害剤 JPH203によるがん放射線増感効果の評価とメカニズムの解明2021
- Author(s)
  房知輝、小林翔、伊藤恒賢、中島修、藤井純逸
- Organizer
  第74回日本酸化ストレス学会/第21回日本NO学会合同学術集会
- Data Source
  KAKENHI-PROJECT-20K22830
[Presentation] LAT1 inhibitor JPH203 enhances radiation-induced cellular senescence by downregulation of mTOR activity2021
- Author(s)
  Tomoki Bo, Sho Kobayashi, Osamu Inanami, Junichi Fujii, Osamu Nakajima, Tsunekata Ito, Hironobu Yasui
- Organizer
  日本放射線影響学会第63回大会
- Data Source
  KAKENHI-PROJECT-21K14971
[Presentation] LAT1 inhibitor JPH203 enhances radiation-induced cellular senescence by downregulation of mTOR activity2021
- Author(s)
  ○Tomoki Bo1, Sho Kobayashi2,3, Osamu Inanami4, Junichi Fujii2, Osamu Nakajima5, Tsunekata Ito1, Hironobu Yasui4
- Organizer
  日本放射線影響学会第63回大会
- Data Source
  KAKENHI-PROJECT-20K22830

1. 藤井順逸 (00222258)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
2. OSAKI Tsukasa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 小林翔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Bo Tomoki 房 知輝

BO Tomoki 房 知輝

Research Projects

Research Products

Co-Researchers

Control mechanism of activated macrophages by enhancement of polyamine-acrolein pathway

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

がん窒素代謝を標的とした新規放射線療法開発のための基盤研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of neutral amino acid metabolism after X-irradiation and Radio-sensitization by targeting amino acid metabolismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

LAT1 inhibitor JPH203 sensitizes cancer cells to radiation by enhancing radiation-induced cellular senescencePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Dephosphorylation of branched-chain α-keto acid dehydrogenase E1α (BCKDHA) promotes branched-chain amino acid catabolism and renders cancer cells resistant to X-rays by mitigating DNA damage2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ascorbic Acid Protects Bone Marrow from Oxidative Stress and Transient Elevation of Corticosterone Caused by X-ray Exposure in Akr1a-Knockout Mice2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Double-decker cage reduces mount frequency and ejaculation latency, resulting in reduced weight loss in male rats after mating behavior2024

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Primary Roles of Branched Chain Amino Acids (BCAAs) and Their Metabolism in Physiology and Metabolic Disorders2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Heme Biosynthesis is Crucial for Cell Survival and Mitochondrial OXPHOS after X Irradiation2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ascorbate Is a Primary Antioxidant in Mammals2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] LAT1 inhibitor JPH203 sensitizes cancer cells to radiation by enhancing radiation-induced cellular senescence2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] アスコルビン酸はAkr1a-KOマウスにおけるX線照射による酸化ストレスおよびコルチコステロンの一過性上昇から骨髄細胞を保護する.2024

Author(s)

Organizer

Data Source

[Presentation] Akr1a-KOマウスにおけるアスコルビン酸欠乏は酸化ストレスとコルチコステロン上昇によってX線照射後の白血球数回復を遅延させる.2024

Author(s)

Organizer

Data Source

[Presentation] Inhibition of BCAT1 and BCKDHα enhances cancer radiosensitivity.2023

Author(s)

Organizer

Data Source

[Presentation] Heme biosynthesis is upregulated to enhance oxidative phosphorylation for cell survival after X-irradiation2023

Author(s)

Bo Tomoki 房知輝

BO Tomoki 房知輝