Nagai Yosuke 永井洋介

Researcher Number	90912634
Other IDs	https://orcid.org/0000-0001-8373-8147
Affiliation (Current)	2026: 東京慈恵会医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2026: 東京慈恵会医科大学, 医学部, 助教 2021 – 2022: 東京慈恵会医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related / 0902:General internal medicine and related fields
Keywords	Principal Investigator 糖尿病腎症 / ミトコンドリア障害 / 脂肪酸代謝 / ROCK1 / Rho-kinase / 糖尿病性腎臓病

血管内皮KLF4による代謝クロストーク制御を介したHFpEF病態の新規解明Principal Investigator
- Principal Investigator
  
  永井洋介
- Project Period (FY)
  2026 – 2027
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Jikei University School of Medicine
Mitochondrial dynamics regulation in diabetic glomeruli via ROCK1/AMPK axisPrincipal Investigator
- Principal Investigator
  
  Nagai Yosuke
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0902:General internal medicine and related fields
- Research Institution
  Jikei University School of Medicine

All 2023 2022 2021

All Journal Article Presentation

[Journal Article] Rho-kinase inhibitor restores glomerular fatty acid metabolism in diabetic kidney disease2023
- Author(s)
  Nagai Yosuke、Matoba Keiichiro、Yako Hideji、Ohashi Shinji、Sekiguchi Kensuke、Mitsuyoshi Etsuko、Sango Kazunori、Kawanami Daiji、Utsunomiya Kazunori、Nishimura Rimei
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 649 Pages: 32-38
- DOI
  10.1016/j.bbrc.2023.01.088
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07773, KAKENHI-PROJECT-20K08645, KAKENHI-PROJECT-21K20914, KAKENHI-PROJECT-22K08347
[Journal Article] ROCK2-induced metabolic rewiring in diabetic podocytopathy2022
- Author(s)
  Matoba Keiichiro、Takeda Yusuke、Nagai Yosuke、Sekiguchi Kensuke、Ukichi Rikako、Takahashi Hiroshi、Aizawa Daisuke、Ikegami Masahiro、Tachibana Toshiaki、Kawanami Daiji、Kanazawa Yasushi、Yokota Tamotsu、Utsunomiya Kazunori、Nishimura Rimei
- Journal Title
  
  Communications Biology
  
  Volume: 5 Issue: 1 Pages: 341-341
- DOI
  10.1038/s42003-022-03300-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08714, KAKENHI-PROJECT-22K16433, KAKENHI-PROJECT-20K08645, KAKENHI-PROJECT-21K20914
[Journal Article] Rho-associated, coiled-coil?containing protein kinase 1 regulates development of diabetic kidney disease via modulation of fatty acid metabolism2022
- Author(s)
  Nagai Yosuke、Matoba Keiichiro、Takeda Yusuke、Yako Hideji、Akamine Tomoyo、Sekiguchi Kensuke、Kanazawa Yasushi、Yokota Tamotsu、Sango Kazunori、Kawanami Daiji、Utsunomiya Kazunori、Nishimura Rimei
- Journal Title
  
  Kidney International
  
  Volume: 102 Issue: 3 Pages: 536-545
- DOI
  10.1016/j.kint.2022.04.021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08347, KAKENHI-PROJECT-20K07773, KAKENHI-PROJECT-20K08645, KAKENHI-PROJECT-21K20914
[Presentation] ROCK1の遺伝的欠損および薬理的阻害は腎糸球体の脂質エネルギー代謝機構を改善させる2022
- Author(s)
  永井洋介、的場圭一郎、関口賢介、竹田裕介、赤嶺友代、金澤康、横田太持、八子英司、三五一憲、川浪大治、宇都宮一典、西村理明
- Organizer
  第37回日本糖尿病合併症学会
- Data Source
  KAKENHI-PROJECT-21K20914
[Presentation] ROCK2による褐色化抑制を介した内臓脂肪蓄積機構2022
- Author(s)
  竹田裕介、的場圭一郎、浮地里佳子、関口賢介、永井洋介、赤嶺友代、金澤　康、横田太持、川浪大治、宇都宮一典、西村理明
- Organizer
  第65回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-21K20914
[Presentation] ROCK1 regulation of AMPK in the development of diabetic nephropathy.2022
- Author(s)
  Yosuke Nagai, Keiichiro Matoba, Kensuke Sekiguchi, Rikako Ukichi, Yusuke Takeda, Tomoyo Akamine, Yasushi Kanzawa, Kazunori Utsunomiya, Rimei Nishimura
- Organizer
  American Diabetes Association 82nd Scientific Sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K20914
[Presentation] 腎尿細管ROCK2の慢性腎臓病進展における病態的意義2022
- Author(s)
  関口賢介、的場圭一郎、大橋慎史、光吉悦子、浮地里佳子、永井洋介、竹田裕介、赤嶺友代、金澤　康、横田太持、川浪大治、宇都宮一典、西村理明
- Organizer
  第37回日本糖尿病合併症学会
- Data Source
  KAKENHI-PROJECT-21K20914
[Presentation] 慢性腎臓病における腎尿細管ROCK2の病態学的役割の検討2022
- Author(s)
  関口賢介、的場圭一郎、浮地里佳子、永井洋介、竹田裕介、赤嶺友代、金澤　康、横田太持、川浪大治、宇都宮一典、西村理明
- Organizer
  第65回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-21K20914
[Presentation] ROCK1による腎糸球体脂質エネルギー代謝機構2022
- Author(s)
  永井洋介、的場圭一郎、関口賢介、竹田裕介、赤嶺友代、金澤　康、横田太持、八子英司、三五一典、川浪大治、宇都宮一典、西村理明
- Organizer
  第65回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-21K20914
[Presentation] ROCK1/AMPK axisを介した脂肪酸の利用障害による糖尿病性腎臓病進展機構2021
- Author(s)
  永井洋介、的場圭一郎、関口賢介、浮地　里佳子、竹田裕介、赤嶺友代、金澤　康、横田太持、川浪大治、宇都宮一典、西村理明
- Organizer
  日本糖尿病合併症学会
- Data Source
  KAKENHI-PROJECT-21K20914
[Presentation] ROCK1/AMPK axis regulates the development of diabetic kidney disease via modulation of fatty acid metabolism2021
- Author(s)
  Yosuke Nagai, Keiichiro Matoba, Kensuke Sekiguchi, Rikako Ukichi, Yusuke Takeda, Tomoyo Akamine, Yasushi Kanzawa, Kazunori Utsunomiya, Rimei Nishimura
- Organizer
  American Diabetes Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K20914
[Presentation] ROCK1/AMPK axisによる脂肪酸の利用障害を介した糖尿病腎症進展機構2021
- Author(s)
  永井洋介、的場圭一郎、竹田裕介、八子英司、関口賢介、赤嶺友代、横田太持、三五一憲、川浪大治、宇都宮一典、西村理明
- Organizer
  日本糖尿病学会
- Data Source
  KAKENHI-PROJECT-21K20914

1. 三五一憲

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 川浪大治

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. 的場圭一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Nagai Yosuke 永井 洋介

Research Projects

Research Products

Co-Researchers

血管内皮KLF4による代謝クロストーク制御を介したHFpEF病態の新規解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mitochondrial dynamics regulation in diabetic glomeruli via ROCK1/AMPK axisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Rho-kinase inhibitor restores glomerular fatty acid metabolism in diabetic kidney disease2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ROCK2-induced metabolic rewiring in diabetic podocytopathy2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Rho-associated, coiled-coil?containing protein kinase 1 regulates development of diabetic kidney disease via modulation of fatty acid metabolism2022

Author(s)

Journal Title

DOI

Data Source

[Presentation] ROCK1の遺伝的欠損および薬理的阻害は腎糸球体の脂質エネルギー代謝機構を改善させる2022

Author(s)

Organizer

Data Source

[Presentation] ROCK2による褐色化抑制を介した内臓脂肪蓄積機構2022

Author(s)

Organizer

Data Source

[Presentation] ROCK1 regulation of AMPK in the development of diabetic nephropathy.2022

Author(s)

Organizer

Data Source

[Presentation] 腎尿細管ROCK2の慢性腎臓病進展における病態的意義2022

Author(s)

Organizer

Data Source

[Presentation] 慢性腎臓病における腎尿細管ROCK2の病態学的役割の検討2022

Author(s)

Organizer

Data Source

[Presentation] ROCK1による腎糸球体脂質エネルギー代謝機構2022

Author(s)

Organizer

Data Source

[Presentation] ROCK1/AMPK axisを介した脂肪酸の利用障害による糖尿病性腎臓病進展機構2021

Author(s)

Organizer

Data Source

[Presentation] ROCK1/AMPK axis regulates the development of diabetic kidney disease via modulation of fatty acid metabolism2021

Author(s)

Organizer

Data Source

[Presentation] ROCK1/AMPK axisによる脂肪酸の利用障害を介した糖尿病腎症進展機構2021

Author(s)

Organizer

Data Source

Nagai Yosuke 永井洋介