AZUMA Takachika 東隆親

Researcher Number	00028234
Other IDs
Affiliation (based on the past Project Information) *help	2013: 東京理科大学, 生命医科学研究所, 教授 1995 – 2003: 東京理科大学, 生命科学研究所, 教授 2000 – 2001: 東京理科大学, 生命科学研究所・生命情報科学研究部門, 教授 1990 – 1994: 名古屋市立大学, 医学部, 助教授
Review Section/Research Field	Principal Investigator Immunology / Laboratory medicine Except Principal Investigator Immunology / Laboratory medicine / Immunology / Digestive surgery
Keywords	Principal Investigator 体細胞突然変異 / somatic hypermutation / 抗体 / トランスジェニックマウス / memory B cell / DNA polymerase / BCR / evolution / antibody / 結合部位 … More / 親和力 / エントロピー / 進化 / 相互作用 / 抗原受容体 / Polκ / 記憶B細胞 / DNAポリメラーゼ / 抗原レセプター / 適応的進化 / high sensitivity / immunoassay / Adenovirus / monoclonal antibody / モノクロナール抗体 / 免疫センサー / モノクローナル抗体 / アデノウイルス / transgenic mice / immunoglobulin genes / intron enhancer / 免疫グロブリン遺伝子 / エンハンサー / Transgenic mouse / Somatic mutation / Immunoglobulin / トランスジェニック / 免疫グロブリン … More Except Principal Investigator MHC / TCR / in vitro / CD19 / B細胞 / 体細胞突然変異 / 抗体 / モノクローナル抗体 / DAF / antagonist / agonist / fluctuation / affinity / Stability / Peptide / アンタゴニスト / アンダゴニスト / アゴニスト / ゆらぎ / アフィニティ / 安定性 / ペプチド / phage display / repertoire / affinity maturation / antibody / 抗原結合部位 / CDRループ / ファージディスプレイ / レパートリー / 親和性成熟 / B cell development / antiboy production / B1 B cell / mice / NOG mice / thymic environment / T cell development / human immune system / オリゴクローン法 / ヒト臍帯血 / ヒト免疫系再構築 / B_1 B Cells / B細胞分化 / 抗体産生 / B_1B Cells / マウス / NOGマウス / 胸腺環境 / T細胞分化 / ヒト免疫系 / Antigen specific / Somatic mutation / B cell / 抗原特異的 / クラススイッチ / 自己抗体 / 自己免疫疾患 / 自己免疫 / 免疫寛容 / MUCI / CD_3 / 膵癌 / BFA / Monoclonal antibody / Tumor / Complement / MCP / HRF20 / 免疫誘導 / C3 / モノクロ-ナル抗体 / 腫瘍細胞 / 補体 Less

The control mechanism of B cells activation due to pKnox1 homeodomain transcription factor
- Principal Investigator
  
  NISHIMURA Miyuki
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Sapporo Medical University
  Tokyo University of Science
MHC/peptides stability and T cell activation-Biophysical bases of synapse formation
- Principal Investigator
  
  KOZONO Haruo
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  TOKYO UNIVERSITY OF SCIENCE
Ability of maturation of antibody affinityPrincipal Investigator
- Principal Investigator
  
  AZUMA Takachika
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Tokyo University of Science
Differentiation-induction of antibody producing human B cells from cord blood CD34+ cells in mice for generating monoclonal antibody used in clinical therapy
- Principal Investigator
  
  HABU Sonoko
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Tokai University
Exploring the immunological and structural basis for obtaining high affinity antibodies facilitating a performance of protein-chip for clinical investigation.
- Principal Investigator
  
  FURUKAWA Koji
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  National Institute of Advanced Industrial Science and Technology (AIST)
  Tokyo University of Science
Establishment of somatic mutation system in vitro.
- Principal Investigator
  
  KOZONO Yuko
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Science University of Tokyo,Research institute for Biological Sciences
Development of high sensitive adeno virus detection systemPrincipal Investigator
- Principal Investigator
  
  AZUMA Takachuka
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Laboratory medicine
- Research Institution
  Tokyo University of Science
IgHintron enhancer acttivity and somatic hypermutationPrincipal Investigator
- Principal Investigator
  
  AZUMA Takachika
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Science University of Tokyo
複特異性抗体による消化器癌治療の臨床応用のための基礎的研究
- Principal Investigator
  
  竹山廣光
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Nagoya City University
HRF20遺伝子の塩基欠落による遺伝的発作性夜間血色素尿症に関する研究
- Principal Investigator
  
  岡田秀親
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nagoya City University
抗HIV/抗CD3 ハイブリッド抗体によるAIDS治療法の開発
- Principal Investigator
  
  岡田秀親
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nagoya City University
HRF20遺伝子の塩基欠落による遺伝的発作性夜間血色素尿症に関する研究
- Principal Investigator
  
  岡田秀親
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nagoya City University
抗HEV/抗CD3ハイブリッド抗体によるAIDS治療法の関発
- Principal Investigator
  
  岡田秀親
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nagoya City University
STUDIES ON THE MECHANISM OF SOMATIC MUTATION OF IMMUNOGLOBLIN GENES USING TRANSGENIC MICE.Principal Investigator
- Principal Investigator
  
  AZUMA Takachika
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  NAGOYA CITY UNIVERSITY SCHOOL OF MEDICINE
腫瘍細胞の補体抵抗性を解除するモノクロ-ナル抗体の研究
- Principal Investigator
  
  岡田秀親
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Nagoya City University
補体反応を活用した抗腫瘍免疫誘導法の研究
- Principal Investigator
  
  OKADA Hidechika
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Nagoya City University

All 2014 2013 2003 2001 2000

All Journal Article Presentation

[Journal Article] Low affinity IgM antibodies lacking somatic hypermutations are produced in the secondary response of C57BL/6 mice to (4-hydroxy-3-nitrophenyl)acetyl hapten2014
- Author(s)
  Akikazu Murakami, Hayato Moriyama, Mina Osako-Kabasawa, Kanako Endo, Miyuki Nishimura, Keiko Udaka, Masamichi Muramatsu, Tasuku Honjo, Takachika Azuma, and Takeyuki Shimizu
- Journal Title
  
  Int. Immunol.
  
  Volume: 26 Issue: 4 Pages: 195-208
- DOI
  10.1093/intimm/dxt057
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570169, KAKENHI-PROJECT-24790481
[Journal Article] Thermodynamic and Kinetic Aspects of Antibody Evolution during the Immune Response to Hapten.2003
- Author(s)
  Sagawa T., Oda M., Ishimura M., Furukawa K., Azuma T.
- Journal Title
  
  Mol.Immunol. 39
  
  Pages: 801-806
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12557239
[Journal Article] Three-dimensional Relationship between H- and L-chain of Antibody.2003
- Author(s)
  Yamamoto Y., Furukawa K., Azuma T.
- Journal Title
  
  Protein Sci. 12・1
  
  Pages: 103-103
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12557239
[Journal Article] Three-dimensional Relationship between H- and L-chain of Antibody.2003
- Author(s)
  Yamamoto Y., Furukawa K., Azuma T.
- Journal Title
  
  Protein Sci. 12-1
  
  Pages: 103-103
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12557239
[Journal Article] A Landscape for Affinity Maturation of Antibody, an Evolutionary Process in Immune Response.2001
- Author(s)
  Furukawa K., Furukawa A., Azuma T.
- Journal Title
  
  Protein Sci. 10・1
  
  Pages: 159-159
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12557239
[Journal Article] A Landscape for Affinity Maturation of Antibody, an Evolutionary Process in Immune Response.2001
- Author(s)
  Furukawa K., Furukawa A., Azuma T.
- Journal Title
  
  Protein Sci. 10-1
  
  Pages: 159-159
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12557239
[Journal Article] A Role of the Third Complementarity Determining Region in the Affinity Maturation of an Antibody.2001
- Author(s)
  Furukawa K., Furukawa A., Azuma T.
- Journal Title
  
  J.Biol.Chem. 276
  
  Pages: 27622-27628
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12557239
[Journal Article] A Role of the Third Complementarity Determining Region in the Affinity Maturation of an Antibody.2001
- Author(s)
  Furukawa K., Shirai H., Azuma T, Nakamura H
- Journal Title
  
  J.Biol.Chem. 276
  
  Pages: 27622-27628
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12557239
[Journal Article] junctional diversityと免疫応答の成熟2000
- Author(s)
  古川功治, 東隆親
- Journal Title
  
  臨床免疫 33
  
  Pages: 719-726
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12557239
[Presentation] ファージライブラリー法を用いた抗体の進化能力のin vitroでの解析2013
- Author(s)
  中山光子，村上明一，西村深雪，岸本英博，内海文彰，東隆親
- Organizer
  日本分子生物学会
- Place of Presentation
  神戸国際展示場
- Data Source
  KAKENHI-PROJECT-24790481
[Presentation] ファージライブラリー方を用いた抗体進化能力のin vitroでの解析2013
- Author(s)
  中山光子,村上明一,西村深雪,岸本英博,内海文彰,東隆親
- Organizer
  第36回分子生物学会
- Place of Presentation
  神戸
- Year and Date
  2013-12-05
- Data Source
  KAKENHI-PROJECT-24790481

1. OKADA Hidechika (30160683)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
2. CAMPBELL Wil (00203422)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. NISHIMURA Miyuki (50609401)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. GOITSUKA Ryo (50301552)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. MURAKAMI Akikazu (00733635)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. ITO Norihiko (80264654)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. OHNO Shigeaki (50002382)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. UCHIO Eichi (70232840)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KOZONO Yuko (30197107)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. HABU Sonoko (30051618)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. IHARA Seiji (50096202)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. ANDOU Kiyoshi (70176014)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TAKI Takao (10046295)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. FURUKAWA Koji (00297631)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
15. NAKAMURA Haruki (80134485)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. KOZONO Haruo (80287482)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. ODA Masayuki (20318231)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 山階学 (10211632)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 岡田則子 (20160682)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 竹山廣光 (00216946)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 水野勇 (20157506)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. SUZUKI Hideo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. MATSUO Katsuhiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. KOJIMA Masaharu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. ARIKUNI Hisashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 清水健之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

AZUMA Takachika 東 隆親

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Ability of maturation of antibody affinityPrincipal Investigator

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Development of high sensitive adeno virus detection systemPrincipal Investigator

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IgHintron enhancer acttivity and somatic hypermutationPrincipal Investigator

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STUDIES ON THE MECHANISM OF SOMATIC MUTATION OF IMMUNOGLOBLIN GENES USING TRANSGENIC MICE.Principal Investigator

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AZUMA Takachika 東隆親