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Habu Sonoko  垣生 園子

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HABU Sonoko  垣生 園子

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Researcher Number 30051618
Affiliation (Current) 2022: 順天堂大学, 医学部, 客員教授
Affiliation (based on the past Project Information) *help 2017: 順天堂大学, 医学部, 客員教授
2009 – 2011: Juntendo University, 医学部, 客員教授
2010: 東海大学, 医学部, 教授
2007: 東海大学, 医学部, 前教授
2000 – 2007: 東海大学, 医学部, 教授 … More
1988 – 1998: Tokai University School of Medicine, Professor, 医学部, 教授
1994: 東海大, 医学部, 教授
1993: 東海大学, 医学部・生体防御機構系免疫学部門, 教授
1992 – 1993: 東海大学, 医学部・生体防御機構系免疫, 教授
1992: 東海大学, 医・生体防御機構系・免疫, 教授
1992: Dept. of Medicine Tokai University, School of Medicine, 生体防御機構系・免疫学, 教授
1991: 東海大学, 医学部免疫学教室, 教授
1990 – 1991: 東海大学, 医学部・免疫学教室, 教授
1989: 東海大学, 医学部免疫学, 教授
1989: 東海大学医学部, 免疫学教室, 教授
1987: 東海大学, 医学部・病理学教室, 教授
1986 – 1987: School of Medicine, Tokai University, 医学部, 助教授
1986: 東海大, 医学部, 助教授 Less
Review Section/Research Field
Principal Investigator
Immunology / Biological Sciences / Immunology / Experimental pathology
Except Principal Investigator
Experimental pathology / Immunology / Laboratory animal science / Gastroenterology / Laboratory animal science / Immunology
Keywords
Principal Investigator
positive selection / トランスジェニックマウス / T細胞レセプター / Idd3 / IL-2 / negative selection / T細胞抗原レセプター / TCR発現 / チロシンリン酸化 / スーパー抗原 … More / アナジー / T細胞分化 / 接着分子 / SCIDマウス / 胸腺細胞 / 胸腺内分化 / DP胸腺細胞 / 細菌性外毒素 / ヒストンアセチル化 / 胸腺ストローマ細胞 / thymus / OVA / Th1 / ZAP-70 / NODマウス / MAPK / 転移 / ホ-ミング関連分子 / DPP IV遺伝子 / ホーミングレセプター / VLA-4 / LFA-1 / 造血細胞 / トランスジエニックマウス / T細胞抗原レセプター(TCR) / MHC拘束性 / NHC拘束性 / ポジティブセレクション / ネガティブセレクション / MHC拘束性 TCR / MHC拘束性TCR / サイトカインストーム / TCRトランスジェニック / 免疫反応抑制 / 免疫不応答性 / サイトカイン嵐 / super antigen / TSST-1 / 記憶T細胞 / ペプチド抗原 / 記憶細胞 / サイトカイン産生 / クロマチンレモデリング / Notch / Notchリガンド / 胸腺上皮細胞 / 胸腺niche / T細胞分化誘導 / delta-like 4 / TSS-1 / クロマチンモデリング / アナジーT細胞 / proximal / distal / enhancer領域 / クロマチンリモデリング / 免疫学 / 胸腺ノッチ / ノッチシグナル / ヒトILー2遺伝子 / ヒトILー2 / くも膜下腔リンパ球浸潤 / 自己免疫病 / アポートシス / 自己反応性T細胞 / 未熟胸腺細胞 / T細胞抗原レセプタ- / クロ-ン選択機構 / 胸線ストロ-マ細胞 / 胸線内分化 / autoimmune disease / T cell antigen receptor(TCR) / apoptosis / self-reactive T cells / thymic stromal cells / intrathymic development / transgenic mouse / 細胞抗原レセプター / T細胞クローン / トランスジェニックスマウス / negataive selection / 抗原特異的クローン / repertoire / MHC restriction / stromal cells / T cells / トレランス / サイトキン / Tolerance / T Cell Receptor / Trancegenic Mouce / Cytokine / コレセプター / positive slection / T細胞レセプター(TCR) / シグナル伝達 / TCRトランスジェニックマウス / CD4 / CD8 / TCR expression / tyrosine phosphorylation / coreceptor / Ii遺伝子 / C型内在性レトロウイルス / NOD mouse / Ii gene / type C endogenous retrovirus / 一型糖尿病 / レトロウイルス感染 / MODマウス / NOD mice / IDDM / retro virus infection / 細胞増殖抑制 / 正の選択的分化 / 遺伝子再構成 / TCR / シスエレメント / germ line転写 / T cell receptor / proliferative inhibition / gene rearrangement / thymocyte / ヒト免疫系 / 胸腺環境 / NOGマウス / マウス / B_1B Cells / 抗体産生 / B細胞分化 / B_1 B Cells / ヒト免疫系再構築 / モノクローナル抗体 / ヒト臍帯血 / オリゴクローン法 / human immune system / T cell development / thymic environment / NOG mice / mice / B1 B cell / antiboy production / B cell development / ヌードマウス / 胸腺非依存性T細胞分化 / 未熟T細胞 / 細胞表面分子 / T細胞分化過程 / 胸腺 / CD_4 / CD_8 / CD_3 / Thy-1陽性細胞 / T細胞表面マーカー / 胸腺外T細胞分化 / Nude mouse / Thymus-independent T cells / Immature T cells / Cell surface molecules … More
Except Principal Investigator
T細胞 / IL-12 / 胸腺 / Notch / レトロウイルス / NK / パーフォリン / ILー2レセプター / 免疫不全マウス / 実験動物 / ストロ-マ細胞 / B細胞 / トランスジェニックマウス / 骨髄 / ストローマ細胞 / 造血幹細胞 / 遺伝子治療 / 発生・分化 / 転写因子 / T cell / LFA-1 / IgE / サイトカイン / Atoh1 / Hath1 / Wnt / D111 / Jagged / G-CSF / HVG / CD4 / SCIDマウス / モデル動物 / 実験動物生産システム / 胚の操作技術 / 実験動物生産・供給システム / エレ-ヌ / cーKit / 細胞接着分子 / モノクロ-ナル抗体 / 細胞間接着分子 / Thyー1分子 / LFAー1 / ICAMー1 / LAK / CTL / ILー7 / SLF / B細胞初期分化 / CD34 / I型糖尿病 / CD48 / 熱帯熱マラリア / 新世界ザル / 動物モデル / 細胞接着因子 / 脳性マラリア / がん免疫 / がん治療 / ヘルパーT細胞 / キラーT細胞 / バイスペシフィック抗体 / 癌 / サイトカイン療法 / 病態モデル / ヒト化動物モデル / NOGマウス / ヒト化モデル / ヒト疾患モデル / MRL / GVHD / Oncgene / TATA / CD2 / 自家骨髄移植 / 癌化学療法 / 乳癌 / 骨髄細胞 / 骨髄非凍結保存 / 自己免疫 / HTLV-1 / 自然免疫 / 骨髄移植 / hemopoietic histocompalibility / NK細胞 / 骨髄progenitor / 脾臓stromal細胞 / マウス / in vitro / Hybrid resistance / CFUーGM / CFU-M / Bone Marrow Transplantation / Hemopoietic Histocompatibility / NK Cell / Bone Marrow Progenitor / Splenic Stromal Cell / Mouse / 分化 / 前駆細胞 / 正の選択 / 決定 / 生長因子 / 胸腺ストローマ細胞 / 増殖因子 / 正・負の選択 / thymus / differentiation / transcription factor / hematopoietic stem cell / progenitor / stromal cell / positive selection / Th1-Th2バランス / 肝障害 / アレルギー / 炎症 / Th1-Th2 balance / liver injury / allergy / T cells / Cytokine / アナジー / TCR-トランスジェニックマウス / メモリー細胞 / IL-2プロモーター / ヒストンアセチル化 / TCRトランスジェニックマウス / TSST-1 / 抗体産生 / anergy / TCR-transgenic mouse / memory cell / IL-2 promoter / histone acetylation / 再生医学 / シグナル伝達 / トランスレーショナルリサーチ / Wntシグナル / Notchシグナル / 細胞内シグナル伝達 / ユビキチン-プロテアソーム / 腸管分化 / Hath-1 / Differentiation / Regenerative medicine / Translational research / Signal transduction / トランジェニックマウス / Jagged1 / 外分泌 / 内分泌 / ノックアウトマウス / グルカゴン / 外分泌細胞 / 内分泌細胞 / 膵 / Dll1 / Pdx-Cre / ER / 膵幹細胞 / リガンド / Noctch / Transgenicmouse / exocrine / endocrine / knockout mouse / Ptfla-Cre / 造血因子 / コロニー刺激因子 / B細胞増殖因子 / BCGF-I / ヒトがん / ヌードマウス / Hemopoietic factor / Colony stimulating factor / B cell growth factor <I> / Human tumor / CEA / 標識抗体 / ミサイル療法 / 免疫療法 / 上皮細胞刷子縁 / 酵素抗体法 / 酵素標識抗体 / Carcinoembryonic antigen / Glucose oxidase-labeled antibody / Galactose oxidase-labeled antibody / 腸内細菌 / 食物繊維 / 短鎖脂肪酸 / 制御性T細胞 / Aire / GPR41 / 酪酸 / 妊娠 / Treg Less
  • Research Projects

    (44 results)
  • Research Products

    (32 results)
  • Co-Researchers

    (84 People)
  •  Maternal high fiber diet during pregnancy and lactation influences regulatory T cell differentiation in offspring in mice

    • Principal Investigator
      NAKAJIMA Akihito
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      Juntendo University
  •  Molecular mechanism of T cell development in Notch signal mediated nitchPrincipal Investigator

    • Principal Investigator
      HABU Sonoko
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      Juntendo University
  •  Basic study to establish "humanized animal model" by improvement and modification of severely immunodeficient NOG mouse

    • Principal Investigator
      ITO Mamoru
    • Project Period (FY)
      2006 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Laboratory animal science
    • Research Institution
      Central Institute for Experimental Animals
  •  Investigative of diffentiation of pancreatic cells and application for treatments for chronic pancreatitis

    • Principal Investigator
      MINE Tetsuya
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokai University
  •  Identification of the crosstalk between Notch signaling and Wnt signaling in the differentiation of the intestinal epithelial cells.

    • Principal Investigator
      WATANABE Mamoru
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  クロマチンリモデリングを指標としたアナジー記憶の誘導と維持機構の解析Principal Investigator

    • Principal Investigator
      垣生 園子
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokai University
  •  スーパー抗原性細菌外毒素に対する記憶T細胞の分化を中心とした免疫応答機構の解析Principal Investigator

    • Principal Investigator
      垣生 園子
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokai University
  •  Notchリガンドの発現・修飾からみた胸腺上皮細胞によるT細胞分化誘導機序Principal Investigator

    • Principal Investigator
      垣生 園子
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Immunology
    • Research Institution
      Tokai University
  •  スーパー抗原性細菌外毒素に対する免疫応答機構の解析Principal Investigator

    • Principal Investigator
      垣生 園子
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokai University
  •  The shift of immune-response and memory T cell differentiation induced by superantigens.

    • Principal Investigator
      KAMETANI Yoshie
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      Tokai University
  •  スーパー抗原性細菌外毒素に対する免疫応答の解析Principal Investigator

    • Principal Investigator
      垣生 園子
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Tokai University
  •  Differentiation-induction of antibody producing human B cells from cord blood CD34+ cells in mice for generating monoclonal antibody used in clinical therapyPrincipal Investigator

    • Principal Investigator
      HABU Sonoko
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      Tokai University
  •  Regulatory mechanism of T cell activation in NOD micePrincipal Investigator

    • Principal Investigator
      HABU Sonoko
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      Immunology
    • Research Institution
      Tokai University
  •  Molecular mechanism of selective development in thymocytes analysing DP specific molculesPrincipal Investigator

    • Principal Investigator
      HABU Sonoko
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      Tokai University
  •  胸腺内分化過程におけるT細胞レセプターの遺伝子再構築を抑制する分子機構Principal Investigator

    • Principal Investigator
      垣生 園子
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokai University
  •  Joint study of antigen presenting activity in NOD micePrincipal Investigator

    • Principal Investigator
      HABU Sonoko
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Tokai University
  •  胸腺内分化モデルの確立による自己認識T細胞クローンの選択機構の解析Principal Investigator

    • Principal Investigator
      垣生 園子
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokai University
  •  IL-12と癌ペプチドを用いた担癌生体内腫瘍特異的免疫の分子制御法の確立

    • Principal Investigator
      西村 孝司
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokai University
  •  Models for studying mechanism of autoimmune diseasePrincipal Investigator

    • Principal Investigator
      HABU Sonoko
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Tokai University
  •  Studies on the mechanism of T cell development in the thymus

    • Principal Investigator
      KATSURA Yoshimoto
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Immunology
    • Research Institution
      KYOTO UNIVERSITY
  •  The molecular mechanism of TCR repertoire generation and coreceptor expressionPrincipal Investigator

    • Principal Investigator
      HABU Sonoko
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      Tokai University
  •  REGULATION OF INFLAMMATORY AND ALLERGY RESPONSES BY ANTI-LFA-1 MONOCLONAL ANTIBODY

    • Principal Investigator
      NISHIMURA Takashi
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      TOKAI UNIVERSITY
  •  胸腺内分化モデルの確立による自己認識T細胞クローンの選択に関する分子免疫学的研究Principal Investigator

    • Principal Investigator
      垣生 園子
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokai University
  •  腫瘍局所免疫(local help)の分子制御法の開発

    • Principal Investigator
      西村 孝司
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokai University
  •  胸腺内分化モデルの確立による自己認識T細胞クローンの選択に関する分子免疫学研究Principal Investigator

    • Principal Investigator
      垣生 園子
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokai University
  •  新世界ザルを用いたヒト熱帯熱マラリアモデルの開発

    • Principal Investigator
      伊藤 守
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      Laboratory animal science
    • Research Institution
      Central Institute for Experimental Animals
  •  リンパ系幹細胞とストローマ細胞間の相互作用に関する研究

    • Principal Investigator
      西川 伸一
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Kumamoto University
  •  動的実験系(Scid-hu)開発による転移機構の解析Principal Investigator

    • Principal Investigator
      垣生 園子
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Tokai University
  •  Establishment of in vitro experimental model for studying molecular mechanism of self-reactive T cell clonePrincipal Investigator

    • Principal Investigator
      HABU Sonoko
    • Project Period (FY)
      1992 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      Tokai Univ.School of Med.
  •  リンパ系幹細胞とストロ-マ細胞間の相互作用に関する研究

    • Principal Investigator
      西川 伸一
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Kumamoto University
  •  癌転移機構の解明を目指したSCIDーhu実験系の開発とホ-ミングレセプタ-の解析Principal Investigator

    • Principal Investigator
      垣生 園子
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Tokai University
  •  Studies of selection mechanism against self reactive T cell clones during intrathymic developmentPrincipal Investigator

    • Principal Investigator
      HABU Sonoko
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Tokai University, School of Medicine
  •  リンパ系幹細胞とストロ-マ細胞間の相互作用に関する研究

    • Principal Investigator
      西川 伸一
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Kumamoto University
  •  抗腫瘍活性発現に重要な新しい細胞間接着分子(LADー1)の機能及び性状の解析

    • Principal Investigator
      NISHIMURA Takashi
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Tokai University
  •  宿主側からみた腫瘍増殖機序の分子免疫学的解析

    • Principal Investigator
      OKUMURA Ko
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Juntendo University
  •  胚の操作技術を用いたSCIDマウスの生産供給システムの開発に関する研究

    • Principal Investigator
      齋藤 宗雄 (斉藤 宗雄)
    • Project Period (FY)
      1989 – 1991
    • Research Category
      Grant-in-Aid for Developmental Scientific Research
    • Research Field
      Laboratory animal science
    • Research Institution
      Central Institute for Experimental Animals
  •  Development of in Vitro Assay System for the Analysis of Transplanted Bone Marrow Cell Rejection

    • Principal Investigator
      SHIMAMURA Kazuo
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Tokai University
  •  宿主側から見た腫瘍増殖機序の分子免疫学的解析

    • Principal Investigator
      奥村 康
    • Project Period (FY)
      1987
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Juntendo University
  •  ILー2がキラー細胞の生体内動態に及ぼす影響についての検討ートランスジェニックマウスを用いてーPrincipal Investigator

    • Principal Investigator
      垣生 園子
    • Project Period (FY)
      1987
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Tokai University
  •  外科的固型癌に対する自家骨髄移植法併用の大量化学療法に関する研究

    • Principal Investigator
      田島 知郎
    • Project Period (FY)
      1987
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Tokai University
  •  宿主側から見た腫瘍増殖機序の分子免疫学的解析

    • Principal Investigator
      奥村 康
    • Project Period (FY)
      1986 – 1988
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Juntendo University
  •  Study of T lymphocytes which develop in the extrathymic tissues.Principal Investigator

    • Principal Investigator
      HABU Sonoko
    • Project Period (FY)
      1986 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Tokai University School of Medicine
  •  Studies on hemopoietic factors produced by human neoplasms.

    • Principal Investigator
      TAMAOKI Norikazu
    • Project Period (FY)
      1985 – 1986
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      School of Medicine, Tokai University
  •  Targetted immunotherapy with enzyme-labeled antibodies

    • Principal Investigator
      NAKANE Kazuo
    • Project Period (FY)
      1985 – 1987
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Tokai University School of Medicine

All 2017 2015 2012 2011 2010 2009 2008 2006 2005 2004

All Journal Article Presentation

  • [Journal Article] Maternal High Fiber Diet during Pregnancy and Lactation Influences Regulatory T Cell Differentiation in Offspring in Mice.2017

    • Author(s)
      Nakajima, A. Kaga, N. Nakanishi, Y. Ohno, H. Miyamoto, J. Kimura, I. Hori, S. Sasaki, T. Hiramatsu, K. Okumura, K. Miyake, S. Habu, S. Watanabe, S.
    • Journal Title

      The Journal of Immunology

      Volume: 199 Pages: 3516-3524

    • DOI

      10.4049/jimmunol.1700248

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-17H05789, KAKENHI-PROJECT-15H04747, KAKENHI-PROJECT-17H04218, KAKENHI-PROJECT-15H05344, KAKENHI-PROJECT-15K08533
  • [Journal Article] Runx1 deficiency in CD4+T cells causes fatal autoimmune inflammatory lung disease due to spontaneous hyperactivation of cells2012

    • Author(s)
      Wong WF, Kohu K, Nakamura A, Ebina M, Kikuchi T, Tazawa R, Tanaka K, Kon S, Funaki T, Sugahara-Tobinai R, Looi CY, Endo S, Funayama R, Kurokawa M, Habu S, Ishii N, Fukumoto M, Nakata K, Takai T, and Satake M
    • Journal Title

      J Immunol

      Volume: 188 Pages: 5408-5420

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390154
  • [Journal Article] GATA-3 regulates contact hyperresponsiveness in a murine model of allergic dermatitis2012

    • Author(s)
      Tama uchi H, Amoh Y, Itoh M, Terashima M, Masuzawa M, Habu S, Katsuoka K and Iwabuchi K
    • Journal Title

      Immunobiology

      Volume: 217 Pages: 446-454

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390154
  • [Journal Article] Notch ligands transduce different magnitudes of signaling critical for determination of T cell fate2010

    • Author(s)
      Abe N, Hosumi K, Yagita H and Habu S
    • Journal Title

      Eur J Immunol

      Volume: 40 Pages: 2608-2617

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390154
  • [Journal Article] IL-10 controls Th2-type cytokine production and eosinophil infiltration in a mouse model of allergic airway inflammation2010

    • Author(s)
      Kosa ka S, Tamauchi H, Terashima M, Maruyama H, Habu S, Kitasato H
    • Journal Title

      Immunobiology

      Volume: 216 Pages: 811-820

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390154
  • [Journal Article] Over-expression of Runxtranscription factor impairs the development of thymocytes from the double-negative to double-positive stages2010

    • Author(s)
      Wong WF, Nakazato M, Watanabe T, Kohu K, Ogata T, Yoshida N, Sotomaru Y, Ito M, Araki K, Telfer J, Fukumoto M, Suzuki D, Sato T, Hozumi K, Habu S, Satake M
    • Journal Title

      Immunology

      Volume: 130 Pages: 243-253

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390154
  • [Journal Article] Th2 Immune Response Plays a Critical Role in the Development of Nickel-Induced Allergic Contact Dermatitis2010

    • Author(s)
      Matsumura Y, Kanoh M, Habu S, Komotori J, Niiyama S, Tamauchi H, Amoh Y, Terashima M, Katsuoka K
    • Journal Title

      Allergy Immunol

      Volume: 153 Pages: 303-314

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390154
  • [Journal Article] Generation of transgenic non-human primates with germline transmission2009

    • Author(s)
      Sasaki E, Suemizu H, Shimada A, Hanazawa K, Oiwa R, Kamioka M, Tomioka I, Sotomaru Y, Hirakawa R, Eto T, Shiozawa S, Maeda T, Ito M, Ito R, Kito C, Yagihashi C, Kawai K, Miyoshi H, Tanioka Y, Tamaoki N, Habu S, Okano H, Nomura T
    • Journal Title

      Nature

      Volume: 459 Pages: 523-527

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390154
  • [Journal Article] Effects of liposome-encapsulated hemoglobin on human immune system: evaluation in immunodeficient mice reconstituted with human cord blood stem cells.2009

    • Author(s)
      Kawaguchi A.T., Y.Kametani, S.Kato, H.Furuya, K.Tamaoki, S.Habu
    • Journal Title

      Artif Organs 33

      Pages: 169-176

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18100005
  • [Journal Article] Development of monoclonal antibodies for analyzing immune and hematopoietic systems of common marmoset2009

    • Author(s)
      Habu S, Stake M
    • Journal Title

      Exp.Hematol 37

      Pages: 1318-1318

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390154
  • [Journal Article] Development of monoclonal antibodies for analyziand hematopoietic systems of common marmoset2009

    • Author(s)
      Kametan i Y, Suzuki D, Kohu K, Satake M, Suemizu H, Sasaki E, Ito T, Tamaoki N, Mizushima T, Ozawa M, Tani K, Kito M, Arai H, Koyanagi A, Yagita H, Habu S
    • Journal Title

      Exp Hematol

      Volume: 37 Pages: 1318-1329

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390154
  • [Journal Article] Generation of transgenic non-human primates with germline transmission2009

    • Author(s)
      Habu S
    • Journal Title

      Nature 459

      Pages: 523-527

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390154
  • [Journal Article] Antigen-specific antibody production of human B cells in NOG mice reconstituted with the human immune system.2008

    • Author(s)
      Ito R., M.Shiina, Y.Saito, Y.Tokuda, Y.Kametani, S.Habu
    • Journal Title

      Curr Top Microbiol Immunol 324

      Pages: 95-107

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18100005
  • [Journal Article] Development of human-human hybridoma from anti-Her-2 peptide-producing B cells in immunized NOG mouse.2006

    • Author(s)
      Kametani Y., M.Shiina, I.Katano, R.Ito, K.Ando, K.Toyama, H.Tsukamoto, T.Matsumura, Y.Saito, D.Ishikawa, T.Taki, M.Ito, K.Imai, Y.Tokuda, S.Kato, N.Tamaoki, S.Habu
    • Journal Title

      Exp Hematol 34

      Pages: 1239-1247

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18100005
  • [Journal Article] Overexpression of the Runx3 transcription factor increases the proportion of mature thymocytes of the CD8 single-positive lineage.2005

    • Author(s)
      Kohu K, Sato T, Watanabe T, Habu S, Satake M.
    • Journal Title

      J Immunol. 174(5)

      Pages: 2627-2636

    • Data Source
      KAKENHI-PROJECT-16017295
  • [Journal Article] Dual functions of Runx proteins for re-activating CD8 and silencing CD4 at the commitment process into CD8 thymocytes2005

    • Author(s)
      Sato T, Ohno S, Hayashi T, Sato C, Kohfu K, Satake M, Habu S
    • Journal Title

      Immunity (in press)

    • Data Source
      KAKENHI-PROJECT-16017295
  • [Journal Article] Immune responses to Nippostrongylus brasiliensis and tuberculin protein in GATA-3-transgenic mice.2005

    • Author(s)
      Ozawa H, Tamauchi H, Ito M, Terashima M, Inoue M, Hozumi K, Habu S
    • Journal Title

      Immunol Lett. 99(2)

      Pages: 228-235

    • Data Source
      KAKENHI-PROJECT-16017295
  • [Journal Article] Dual functions of Runx proteins for reactivating CD8 and silencing CD4 at the commitment process into CD8 thymocytes.2005

    • Author(s)
      Sato T, Ohno S, Hayashi T, Sato C, Kohu K, Satake M, Habu S.
    • Journal Title

      Immunity. 22(3)

      Pages: 317-328

    • Data Source
      KAKENHI-PROJECT-16017295
  • [Journal Article] Over-expression of the Runx3 Transcription Factor Increases the Proportion of Mature Thymocytes of the CD8 Single Positive Lineage2005

    • Author(s)
      Kohu K, Sato T, Ohno S, Habu S, Satake M., et al.(14人中13番目)
    • Journal Title

      J.Immunology (in press)

    • Data Source
      KAKENHI-PROJECT-16017295
  • [Journal Article] The limited positional effects of Eb to the Vb gene o on the ordered rearrangement and allelic exclusion.2005

    • Author(s)
      Suzuki D, Senoo M, Wang L, Habu S.
    • Journal Title

      Int.Immunol 17(12)

      Pages: 1553-1560

    • Data Source
      KAKENHI-PROJECT-16017295
  • [Journal Article] T-cell specific enhancement of histone H3 acetylation in 5' flanking region of the IL-2 gene.2005

    • Author(s)
      Wang L, Kametani Y, Katano I, Habu S.
    • Journal Title

      Biochem Biophys Res Commun. 331(2)

      Pages: 589-594

    • Data Source
      KAKENHI-PROJECT-16017295
  • [Journal Article] Evidence of GATA-3-dependent Th2 commitment during the in vivo immune response.2004

    • Author(s)
      Tamauchi H, Terashima M, Ito M, Maruyama H, Ikewaki N, Inoue M, Gao X, Hozumi K, Habu S.
    • Journal Title

      Int Immunol. 16

      Pages: 179-187

    • Data Source
      KAKENHI-PROJECT-16017295
  • [Journal Article] Transient suppression of IgG1 with IL-6 over-expression in immunized TCR-transgenic mice.2004

    • Author(s)
      Kametani Y, Katano I, Takei E, Habu S
    • Journal Title

      Immunol Lett. 93(1

      Pages: 27-32

    • Data Source
      KAKENHI-PROJECT-16017295
  • [Journal Article] Evidence of GATA-3-dependent Th2 commitment during the in vivo immune response.2004

    • Author(s)
      Tamauchi, H., Terashima M, Ito M, Habu S.
    • Journal Title

      Int Immunol 16

      Pages: 179-187

    • Data Source
      KAKENHI-PROJECT-16017295
  • [Journal Article] Transient suppression of IgG1 with IL-6 over-expression in immunized TCR-transgenic mice.2004

    • Author(s)
      Kametani Y, Katano I, Hirano Y, Mochida N, Takei E, Habu S.
    • Journal Title

      Immunol Lett. 93

      Pages: 27-32

    • Data Source
      KAKENHI-PROJECT-16017295
  • [Journal Article] Delta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivo.2004

    • Author(s)
      Hozumi K, Negishi N, Habu S, Owen MJ. et al.(10人中9番目)
    • Journal Title

      Nat Immunol. 5

      Pages: 638-644

    • Data Source
      KAKENHI-PROJECT-16017295
  • [Journal Article] Delta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivo.2004

    • Author(s)
      Hozumi K, Negishi N, Horowicz D, Habu S
    • Journal Title

      Nat Immunol. 5(6

      Pages: 638-644

    • Data Source
      KAKENHI-PROJECT-16017295
  • [Presentation] The effect of dietary fiber during pregnancy on Foxp3+tTregs of offspring2015

    • Author(s)
      Akihito Nakajima, Sachiko Miyake and Sonoko Habu
    • Organizer
      第44回日本免疫学会
    • Place of Presentation
      札幌
    • Year and Date
      2015-11-18
    • Data Source
      KAKENHI-PROJECT-15K08533
  • [Presentation] Increase of transplanted human hematopoietic stem cells in transgenic NOG mice expressing human Jagged-1 in osteoblasts2011

    • Author(s)
      Negishi N, Ito R, Hozumi K, Ando K, Habu S
    • Organizer
      3rd international workshop on humanized mice
    • Place of Presentation
      Pittsburgh, USA
    • Data Source
      KAKENHI-PROJECT-21390154
  • [Presentation] B細胞エピトープに基づく新規HER2ペプチドワクチンの抗腫瘍効果2010

    • Author(s)
      三朝博仁、亀谷美恵、片野いくみ、伊藤亮治、古川敦子、津田万里、今井浩三、垣生園子、幕内博康、徳田裕
    • Organizer
      第13回日本がん免疫学会総会
    • Year and Date
      2010-07-22
    • Data Source
      KAKENHI-PROJECT-21390154
  • [Presentation] Evidence for the coupling of DNA replication control and lineage choice into CD4/8 thymocytes(CD4/8胸腺細胞分化とDNA複製制御は共役する)2009

    • Author(s)
      Sato T, Chiba T, Sugou T, Satake M, Habu S
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Data Source
      KAKENHI-PROJECT-21390154
  • [Presentation] The physiological significance of D114 for T cell development in the thymus(胸腺内T細胞分化におけるD114の生理的役割)2009

    • Author(s)
      Hozumi K, Hirano K, Nakano Y, Yagita H, Habu S
    • Organizer
      第39回日本免疫学会総愛・学術集会
    • Year and Date
      2009-12-12
    • Data Source
      KAKENHI-PROJECT-21390154
  • 1.  NISHIMURA Takashi (30143001)
    # of Collaborated Projects: 11 results
    # of Collaborated Products: 0 results
  • 2.  SATO Takehito (50235363)
    # of Collaborated Projects: 9 results
    # of Collaborated Products: 0 results
  • 3.  ANDO Kiyoshi (70176014)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 1 results
  • 4.  OKUMURA Ko (50009700)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 1 results
  • 5.  TAMAOKI Norikazu (50055860)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 6.  ITO Mamoru (00176364)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 2 results
  • 7.  HOZUMI Katsuto (30246079)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 8.  UEYAMA Yoshito (30072408)
    # of Collaborated Projects: 3 results
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  • 9.  KATSUKI Motoya (20051732)
    # of Collaborated Projects: 3 results
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  • 10.  藤原 大美 (70116094)
    # of Collaborated Projects: 3 results
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  • 11.  吉田 孝人 (90041847)
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  • 12.  佐藤 昇志 (50158937)
    # of Collaborated Projects: 3 results
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  • 13.  白井 俊一 (30115860)
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  • 14.  西川 伸一 (60127115)
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  • 15.  菊谷 仁 (80161412)
    # of Collaborated Projects: 3 results
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  • 16.  八木田 秀雄 (30182306)
    # of Collaborated Projects: 3 results
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  • 17.  猪子 英俊 (10101932)
    # of Collaborated Projects: 3 results
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  • 18.  木村 穣 (10146706)
    # of Collaborated Projects: 2 results
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  • 19.  SATAKE Masanobu (50178688)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 20.  宮崎 純一 (10200156)
    # of Collaborated Projects: 2 results
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  • 21.  熊谷 善博 (80175314)
    # of Collaborated Projects: 2 results
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  • 22.  SIMPSON Elizabeth
    # of Collaborated Projects: 2 results
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  • 23.  MIYAKAWA Yoshitaka (50250238)
    # of Collaborated Projects: 1 results
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  • 24.  SUZUE Kazutomo (00333485)
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  • 25.  SUEMIZU Hiroshi (40332209)
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  • 26.  MAEDA Keiko (20053374)
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  • 27.  SHIMAMURA Kazuo (00119679)
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  • 28.  KATSURA Yoshimoto (90027095)
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  • 29.  HIROKAWA Katsuiku (00014093)
    # of Collaborated Projects: 1 results
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  • 30.  SAITO Takashi (50205655)
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  • 31.  SASAZUKI Takehiko (50014121)
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  • 38.  TSUCHIYA Kiichiro (40376786)
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  • 40.  HANDA Hiroshi (80107432)
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  • 43.  TADA Nobuhiko (80167494)
    # of Collaborated Projects: 1 results
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  • 44.  NAKANE Kazuo (60164240)
    # of Collaborated Projects: 1 results
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  • 45.  MORIUCHI Tetsuya (20174394)
    # of Collaborated Projects: 1 results
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  • 46.  NAKAJIMA Akihito (30439294)
    # of Collaborated Projects: 1 results
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    # of Collaborated Projects: 1 results
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  • 48.  HIRAMATSU Keiichi (10173262)
    # of Collaborated Projects: 1 results
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  • 50.  NAKANISHI Yumiko (10614274)
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  • 51.  OHNO Hiroshi (50233226)
    # of Collaborated Projects: 1 results
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  • 55.  野村 達次 (10072399)
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  • 56.  木梨 達雄 (30202039)
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  • 57.  山口 祐司 (00220286)
    # of Collaborated Projects: 1 results
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  • 58.  緒方 正人 (60224094)
    # of Collaborated Projects: 1 results
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  • 59.  仲野 徹 (00172370)
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  • 60.  猪口 貞樹 (60160008)
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  • 61.  服部 正策 (00164864)
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  • 65.  横山 峯介 (40090930)
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  • 66.  田島 知郎 (20056005)
    # of Collaborated Projects: 1 results
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  • 67.  徳田 裕 (20163975)
    # of Collaborated Projects: 1 results
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  • 68.  篠塚 孝男 (30110901)
    # of Collaborated Projects: 1 results
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  • 69.  渡辺 克仁 (90102855)
    # of Collaborated Projects: 1 results
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  • 70.  横山 清七 (50096278)
    # of Collaborated Projects: 1 results
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  • 71.  仙道 富士郎 (80091833)
    # of Collaborated Projects: 1 results
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  • 72.  佐辺 寿孝 (40187282)
    # of Collaborated Projects: 1 results
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  • 73.  岡田 秀親 (30160683)
    # of Collaborated Projects: 1 results
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  • 74.  吉木 敬 (60220612)
    # of Collaborated Projects: 1 results
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  • 75.  中内 啓光 (40175485)
    # of Collaborated Projects: 1 results
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  • 76.  徳久 剛史 (20134364)
    # of Collaborated Projects: 1 results
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  • 77.  日合 弘 (10073131)
    # of Collaborated Projects: 1 results
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  • 78.  赤松 健一
    # of Collaborated Projects: 1 results
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  • 79.  DENNIS Y LOH
    # of Collaborated Projects: 1 results
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  • 80.  LOH Dennis Y.
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 81.  LOH Dennis Y
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 82.  ZINKERNAGEL アール エム
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 83.  ZINKERNAGEL Rolf Martin
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 84.  木村 郁夫
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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