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Yagita Hideo  八木田 秀雄

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… Alternative Names

YAGITA Hideo  八木田 秀雄

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Researcher Number 30182306
Other IDs
Affiliation (Current) 2022: 順天堂大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2017: 順天堂大学, 医学部 免疫学講座, 準教授
2007 – 2016: Juntendo University, Immunology, Associate professor
2012: 順天堂大学, 医学部, 先任准教授
2008 – 2009: 順天堂大学, 医学部, 先任准教授
1988 – 2006: Associate Professor, Juntendo Univ., Sch. of Medicine, 医学部, 助教授 … More
2005: 順天堂大学, 医学部, 教授
2004: Juntendou Univ.Sch.Med., Dep.Immunol., Associate Professor
1998: 順天堂大学, 医学部・免疫学講座, 助教授
1996: 国立小児病院, 小児医療研究センター・順天堂大学・医学部・免疫学, 助教授
1992: 順天堂大, 医・免疫, 助教授
1992: 順天堂大, 医学部, 助教授
1990 – 1991: 順天堂大学, 医学部, 講師
1990 – 1991: 順天堂大学, 医学部・免疫, 助教授
1990: 順天堂大学, 医学部・免疫学, 助教授
1988: 順天堂大学, 医学部
1988: 順天堂大学, 医学部免疫学研究室, 助教授
1987: 順天堂大学, 医学部, 講師
1986: 順天堂大学, 医学部, 助手
1986: 順天堂大学, 医学部・免疫学研究室, 助手 Less
Review Section/Research Field
Principal Investigator
Immunology / Biological Sciences / Tumor immunology / Tumor therapeutics
Except Principal Investigator
Immunology / Biological Sciences / Hematology / 内科学一般 / Ophthalmology / Cerebral neurosurgery … More / Respiratory organ internal medicine / General pharmacology / Gastroenterology / Gastroenterology / Experimental pathology / 膠原病・アレルギー・感染症内科学 / Respiratory organ internal medicine / Pediatrics Less
Keywords
Principal Investigator
CD27 / DR5 / TWEAK / TRAIL / CD2 / キラーT細胞 / CD70 / LFA-1 / ICAM-1 / OX40 … More / CD40 / NK細胞 / Fasリガンド / Fas / 自己免疫疾患 / がん / 免疫 / 抗体療法 / PD-1 / 4-1BB / Fn14 / CD48 / tolerance / 移植 / IL-12 / FasL / アポトーシス / GVHD / 免疫賦活化 / Tim-3 / CTL / CD137 / NKT細胞 / CD94 / NKG2A / ICOS / CTLA-4 / T細胞活性化 / トレランス / CD4 / CD8 / VLA-4 / VCAM-1 / CD28 / CD80, CD86 / 接着分子 / transplantation / autoimmune disease / immune privilege / Th1 / Th2 / costimulation / 4-1BBL / CD30L / CD30 / TRANCE / RANK / LAK / NK / ILー2 / ILー2受容体 / 細胞障害性 / MHC非拘束性認識 / パーフォリン / 二反応性抗体 / 細胞傷害機序 / パ-フォリン / 好中球 / 細胞障害機序 / グランザイム / ICE / アポートシス / OX40リガンド / 腫瘍の転移 / ナチュラルキラー細胞 / B7-H3 / D114 / 膵癌 / 抗DR5抗体 / プロテアソーム阻害剤 / ヒストン脱アセチル化酵素阻害剤 / 抗ErbB-2抗体 / IL-21 / 乳癌 / 腎癌 / α-GalCer / PD-L1 / plasmacytoid DC / 樹状細胞 / TIM-3 / MFG-E8 / aV integrin / HMGB1 / IL-13Rα2 / αVβ3インテグリン / ErbB-2 / Notch2 / VISTA / IFN / Notch / RANKL / Lybhokine-activatedkiller / T細胞抗原レセプター / CD3 / CD16 / ヒト脳腫瘍の治療 / Poreforming Protein / 細胞間接着分子 / 細胞外マトリクス受容体 / インテグリン / LFAー1 / ICAMー1 / T細胞分化 / CD_2 / CD11a / 18 / CD54 / adhesion molecules / extracellular matrix receptor / T cell activation / integrins / LFA-3,CD48 / CD80,CD86 / LFA-3, CD48 / 免疫寛容 / CD80 / CD86 / CD95 / 腫瘍 / 免疫監視 / 活性化受容体 / 抑制性受容体 / 転移 / ネクローシス / IFN-γ / 免疫監視機構 / 発癌 / NK cells / tumor / immune surveillance / activating receptor / inhibitory receptor / OX40L / TNF / 腫瘍免疫 / 自己免疫 / 細胞死 / OX4OL / 0X40 / T細胞 / B細胞 / 分化 / 活性化 / 単クロ-ン抗体 / マウス / cDNA / モノクローナル抗体 / トランスフェクタント / リンパ球機能 / T細胞の分化 / B細胞の分化 / T cell / B cell / NK cell / Differentiation / Activation / Adhesion molecule / Monoclonal antibody … More
Except Principal Investigator
Fas / FasL / LFA / VLA / CD2 / CD80 / アポトーシス / CD86 / CD28 / GVHD / NK細胞 / パーフォリン / CD48 / TWEAK / TNF-α / MPI / HVG / GVH / metalloproteinase inhibitor / GVL / CD8 / パ-フォリン / LAK細胞 / 接着分子 / B細胞 / T細胞 / モノクロ-ナル抗体 / 抗体療法 / バイスペシフィック抗体 / がん遺伝子産物 / 画像診断 / イディオタイプ抗体 / NK / T細胞活性化 / キラー細胞 / VLA-4 / TRAIL / TNF / IL-7 / 慢性大腸炎 / 再生医療 / 炎症性腸疾患 / tolerance / Th1 / Th2 / HVGD / IL-4 / メタロプロテナーゼインヒビター / HIV / CD4 / キラ-細胞 / マクロファ-ジ / ストロ-マ細胞 / トランスジェニックマウス / ガングリオシド抗原 / LAK / 胸腺 / T細胞受容体 / ECM / モノクローナル抗体 / キラーT細胞 / インテグリン / フィブロネクチン / CTLA-4 / IL-7レセプター / 腸管免疫 / 粘膜リンパ球 / 腸管上皮細胞 / Notchシグナル / 免疫特権 / 副刺激シグナル / 移植免疫応答 / ICOS/B7RP-1(ICOSL) / ICOS/B7RP-1 / mAb / lymphocyte / トランスフェクタント / T cell / monoclonal antibody / VLA-5 / TNF-R / 全身性エリテマトーデス / CCR5 / CCR4 / TNF-alpha / 腸内細菌 / 自然免疫 / IgA / 自己免疫疾患 / Fn14 / 血管新生 / IL-2R / 標的細胞破壊 / キラ-因子 / バクスペンフィック抗体 / エレ-ヌ / cーKit / 細胞接着分子 / Perforin / r / 8 T cell / ヒトT細胞抗原 / 10D1 / T細胞分化 / ILー2 / ILー2R / キラ-T細胞 / 共焦点レザ-顕微鏡 / 骨髄 / ILー7 / SLF / ガングリオシ-ド抗原 / Killer T / 腫瘍細胞破壊機構 / 抗原ペプチド / マクロファージレクチン / 共集点レーザー顕微鏡 / B細胞初期分化 / ストローマ細胞 / 造血幹細胞 / CD34 / I型糖尿病 / 糖鎖転移酵素遺伝子 / NKレセプター / リガンド分子 / レクチン / 細胞障害機序 / B7 / B70 / 造血 / 赤芽球 / 赤芽球コロニー / 胎仔肝 / レトロウイルスベクター / 細胞ターゲッティング / 双特異性抗体 / 白血病細胞 / CALLA抗体 / 単クローン抗体 / 悪性グリオーマ / 腫瘍浸潤リンパ球 / T細胞抗原レセプター / 遺伝子治療 / 共刺激分子 / 免疫制御 / 免疫応答 / 86 / T細胞死 / CD4分子 / gp120 / AIDS / マトリックスメタロプロテアーゼ / SIV感染カニクイサル / 細胞障害性リンパ球 / Fasリガンド / 生体防御 / 抗腫瘍効果 / CTL / IFN / 細胞傷害活性 / 血清ホモシスチン / 葉酸 / ビタミンB12 / ビタミンB6 / 無症候性脳梗塞 / 寿命 / メチレンテトラハイドロ葉酸還元酵素 / ビタミンB_6 / ビタミンB_<12> / 骨髄細胞 / 転写因子 / transdifferentiation / 杯細胞分化 / Interferon Regulatory Factor (IRF) / Wntシグナル / 抗腫瘍免疫 / DR5 / 腫瘍細胞 / 局在 / がん抗体療法 / 胆管閉塞 / Importin β1 / PSC / TRAILレセプター / Galectin-9/Tim-3 / GITR/GITRL / ICOS/ICOSL / リンパ腫 / リンパ球の分化 / ホーミング / 分化抗原 / クローナリティー / T細胞レセプター遺伝子 / 免疫グロブリン遺伝子 / lympocyte / TcR / トレランス / 自己免疫 / 移植 / モノクロナール抗体 / 移植拒絶 / Thy-1 / ヘルパーT細胞 / 免疫寛容 / 拒絶反応 / allograft rejection / auto immune disease / マスト細胞 / FcεRI / IgE / 活性化 / フィブロネクチン(FN) / ビトロネクチン(VN) / ラミニン(LM) / コラーゲン(CL) / VLA-3,4,5 / RGDペプチド / 抗VLA-4抗体 / fibronectin / fibronectin receptor / rat mast cells / CD40 / ジーンターゲッティン / CD80,CD86 / CD27 / CD95L / 寛容 / アナジー / エイズ / anergy / HLA-classII / 児 / 抗核抗体 / HLA-class II / 妊娠 / SLE / HLA-classll / children / antinuclear antibodies / B cell / ルーブス腎炎 / ケモカインレセプター / シェーグレン症候群 / ループス腎炎 / 補体(CH50、C3) / Systemic Lupus Erythemotosus / Lupus Nephritis / Chemokine Receptor / sjogren's syndrome / 遺伝子 / 癌抗原 / ペプチド / 免疫 / ワクチン / 探索的臨床研究 / テーラーメイド型医療 / 拒絶抗原 / がん / 抗原 / 免疫療法 / Gene / Tumor antigen / Peptide / Immunity / Cytotoxic T lymphocytes / Vaccine / Translational reearch / Personalized medicine / 腫瘍壊死因子 / costimulatory molecule / 乳酸菌 / マウス実験腸炎モデル / OX40 / inflammatory bowel disease / therapy / mucosal immunity / oral tolerance / commensal bacteria / chronic colitis / costimulation / マウスモデル / 抗原特異性 / クローン病 / 潰瘍性大腸炎 / プロバイオテクス / 細胞移入 / 調節性T細胞 / 調節製T細胞 / 腸管粘膜免疫 / 単クローン / 慢性大腸炎モデル / inflammatory bowel diseases / murine model / Antigen-specific / Crohn's disease / Ulcerative colitis / Probiotics / Cell transfer / Transgenic mice / 腫瘍 / サイトカイン / 腫瘍拒絶 / IκBα / IL-8 / GM-CSF / RANTES / 炎症 / tumor / apoptosis / cytokine / angiogenesis / tumor rejection / 関節炎モデル / 実験的自己免疫性ぶどう膜網膜炎 / OVA誘発性喘息 / 実験的自己免疫性脳脊髄炎 / 補助シグナル分子 / CD28-B7ファミリー / TNF-TNFRファミリー / コラーゲン誘発性関節炎 / B7RP-1 / autoimmune diseases / collagen-induced arthritis / experimental autoimmune uveoretinitis / murine model of asthma / experimental autoimmune encephalomyelitis / costimulatory molecules / CD28-B7 family / TNF-TNFR family / TS / トランスフェクション / CD8遺伝子 / CD2遺伝子 / リンパ球機能分子 / FACS / DNAクローニング / サプレッサーT細胞 / T細胞レセプター / T細胞機能分子 / Ts / Monoclonal Antibody / 腫瘍微小環境 / リンパ管新生 / 腫瘍免疫 / 抗リンパ管新生療法 / 抗血管新生療法 / 血管 / リンパ管 / VISTAシグナル / がん免疫療法 / がんワクチン療法 / CD4陽性T細胞 / 細胞傷害性T細胞 / 樹状細胞 / 難治性がん / 癌免疫療法 / 活性化T細胞療法 / 癌ワクチン療法 / 樹状細胞ワクチン療法 / Notch ligand Delta4 / 樹状細胞ワクチン Less
  • Research Projects

    (61 results)
  • Research Products

    (199 results)
  • Co-Researchers

    (121 People)
  •  Cancer vaccine with Th1 inducing DC through Notch ligand Dll4

    • Principal Investigator
      Mochizuki Kazuhiro
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Fukushima Medical University
  •  Establishment of immuno-stimulatory antibody therapy against cancerPrincipal Investigator

    • Principal Investigator
      YAGITA Hideo
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Tumor therapeutics
    • Research Institution
      Juntendo University
  •  Sunitinib improves tumor microenvironment and augments the T cell infiltration and the effect of immunotherapy by DR-5

    • Principal Investigator
      Okazaki Tatsuma
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Tohoku University
  •  Immune regulation for tissue transplantation and regeneration in the eye

    • Principal Investigator
      Hori Junko
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Ophthalmology
    • Research Institution
      Nippon Medical School
  •  Molecular mechanisms of immunosuppressive intraocular microenvironment in corneal transplantation

    • Principal Investigator
      HORI Junko
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Ophthalmology
    • Research Institution
      Nippon Medical School
  •  Development of immuno-stimulatory antibody therapy against cancerPrincipal Investigator

    • Principal Investigator
      YAGITA Hideo
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Tumor immunology
    • Research Institution
      Juntendo University
  •  Contribution of intracellular TRAIL receptor to regulation of apoptosis induced by TRAIL

    • Principal Investigator
      KOJIMA Yuko
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Juntendo University
  •  Functional analysis of costimulatory molecules for autoimmune diseases

    • Principal Investigator
      OKUMURA Ko
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      Juntendo University
  •  Molecular mechanism of cancer immunosurveillance and its application to cancer therapyPrincipal Investigator

    • Principal Investigator
      YAGITA Hideo
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Juntendo University
  •  粘膜免疫の特殊性を応用した腸管免疫統御療法の開発

    • Principal Investigator
      渡辺 守
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University
  •  REGULATION OF TUMOR VESSEL FORMATION BY THE IMMUNE SYSTEM

    • Principal Investigator
      OKUMURA Ko
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      JUNTENDO UNIVERSITY
  •  粘膜免疫の特殊性を応用した腸管免疫統御療法の開発

    • Principal Investigator
      渡辺 守
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University
  •  Establishment of transgenic mice that recognize bacteria specific antigen and develop spontaneous colitis under specific pathogen free condition.

    • Principal Investigator
      KANAI Takanori
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  消化管粘膜免疫の特殊性を応用した腸管免疫機構の統御療法

    • Principal Investigator
      WATANABE Mamoru
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University
  •  Physiological and pathological functions of TNF/TNF receptor family molecules.Principal Investigator

    • Principal Investigator
      YAGITA Hideo
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      Juntendo University
  •  Molecular mechanisms for tumor recognition and destruction by NK cells.Principal Investigator

    • Principal Investigator
      YAGITA Hideo
    • Project Period (FY)
      2001 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Juntendo University
  •  Establishment of a novel therapy of Inflammatory bowel disease by inducible oral tolerance

    • Principal Investigator
      KANAI Takanori
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  TNF/TNF受容体ファミリー分子の発現と機能の解析Principal Investigator

    • Principal Investigator
      八木田 秀雄
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      Juntendo University
  •  Study of tumor associated antigens recognized by human CD8^+ cytotoxic T lymphocytes

    • Principal Investigator
      ITOH Kyogo
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kurume University School of Medicine
  •  Differential effects of anti Fas ligand and MPI on GVHD pathologies

    • Principal Investigator
      HIRANO Takao
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Juntendo University
  •  Differential effects of anti Fas ligand and anti TNF-alpha antibodies on GVHD pathologies

    • Principal Investigator
      HIRANO takao
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Juntendo University
  •  細胞障害性リンパ球による標的細胞破壊機構の解明およびその制御

    • Principal Investigator
      奥村 康
    • Project Period (FY)
      1999 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      Juntendo University
  •  ヒトの寿命とメチレンテトラハイドロ葉酸還元酵素遺伝子異常

    • Principal Investigator
      佐々木 英忠
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Tohoku University
  •  A metalloproteinase inhibitor prevents acute graft-versus-host disease while preserving graft-versus-leukemia effect of allogeneic bone marrow transplantation

    • Principal Investigator
      MIYAJIMA Hiroaki
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      JUNTENDO UNIVERSITY
  •  Analysis of Thl/Th2 imbalance of systemic lupus erythematosus

    • Principal Investigator
      YAMADA Masato
    • Project Period (FY)
      1999 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      Juntendo University
  •  HIV感染におけるT細胞アポトーシス誘導機序

    • Principal Investigator
      小柳津 直樹
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University
  •  細胞死(アポトーシス)誘導分子をターゲットとしたAIDS発症抑制

    • Principal Investigator
      奥村 康
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      Juntendo University
  •  A long duration follow up of childern born to patients With systematic lupus erythematosus (SLE)

    • Principal Investigator
      HASHIMOTO Hiroshi
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      内科学一般
    • Research Institution
      Juntendo University
  •  CD28シグナル制御による免疫応答調節とその分子機構の解折

    • Principal Investigator
      東 みゆき
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      National Research Institute for Child Health and Development
  •  Analyses on artifical induction of antigen-specific immunological tolerancePrincipal Investigator

    • Principal Investigator
      YAGITA Hideo
    • Project Period (FY)
      1996 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      Juntendo University School of Medicine
  •  CD28シグナル制御による免疫応答調節とその分子機構解析

    • Principal Investigator
      AZUMA Miyuki
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      Juntendo University
  •  Studies on the differention and activation mechanisms of T cell vi lymphocye functioning antigen (LFA).

    • Principal Investigator
      OKUMURA Ko
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Immunology
    • Research Institution
      Juntendo University School of Medicine
  •  抗潰瘍エフェクター機序の解析Principal Investigator

    • Principal Investigator
      八木田 秀雄
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Juntendo University
  •  悪性グリオーマ浸潤リンパ球に於けるT細胞抗原レセプターの分子生物学的解析

    • Principal Investigator
      新田 泰三
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Juntendo University
  •  インテグリン分子のリンパ球・血液細胞の分化に果たす役割

    • Principal Investigator
      武内 ゆみ子
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      The University of Tokyo
  •  レトロウイルスベクター系を用いた腫瘍細胞ターゲッティング法の開発:癌・白血病の遺伝子治療にむけたレトロウイルスベクターへの悪性リンパ腫特定細胞親和性の賦与

    • Principal Investigator
      谷 憲三朗
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      The University of Tokyo
  •  Analysis of adhesion molecules on mast cells

    • Principal Investigator
      HIRANO Takao, 奥村 康
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Juntendo University
  •  Analyzes on artifical induction of antigen-specific immunological tolerancePrincipal Investigator

    • Principal Investigator
      YAGITA Hideo
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      Juntendo University, School of Medicine
  •  腫瘍細胞破壊のキラーメカニズム

    • Principal Investigator
      橋本 嘉幸
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Tohoku University
  •  リンパ系幹細胞とストローマ細胞間の相互作用に関する研究

    • Principal Investigator
      西川 伸一
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Kumamoto University
  •  モノクローナル抗体による腫瘍関連抗原の検出と治療への応用

    • Principal Investigator
      高橋 利忠
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Aichi Cancer Center Research Institute
  •  研究課的ヒトキラー細胞に発現する新しいレクチン様分子の構造と腫瘍障害性における機能の解析

    • Principal Investigator
      屋部 登志雄
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Juntendo University
  •  キラーT細胞による腫瘍細胞の認識と破壊機構の解明Principal Investigator

    • Principal Investigator
      八木田 秀雄, 奥村 康
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Juntendo University
  •  Sudies on the differention and activation mechanisms of T cell via lymphocye functioning antigen (LFA).

    • Principal Investigator
      OKUMURA Ko
    • Project Period (FY)
      1992 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      Immunology
    • Research Institution
      Juntendo University
  •  腫瘍細胞破壊のキラ-メカニズム

    • Principal Investigator
      橋本 嘉幸
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Tohoku University
  •  リンパ系幹細胞とストロ-マ細胞間の相互作用に関する研究

    • Principal Investigator
      西川 伸一
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Kumamoto University
  •  モノクロ-ナル抗体による腫瘍関連抗原の検出と治療への応用

    • Principal Investigator
      高橋 利忠
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Aichi Cancer Center Research Institute
  •  腫瘍細胞破壊のキラ-メカニズム

    • Principal Investigator
      橋本 嘉幸
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Tohoku University
  •  リンパ系幹細胞とストロ-マ細胞間の相互作用に関する研究

    • Principal Investigator
      西川 伸一
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Kumamoto University
  •  モノクロ-ナル抗体による腫瘍関連抗原の検出と治療への応用

    • Principal Investigator
      高橋 利忠
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Aichi Cancer Center Research Institute
  •  キラ-T細胞による腫瘍細胞の認識と破壊機構の解明

    • Principal Investigator
      奥村 康
    • Project Period (FY)
      1990 – 1992
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Juntendo University
  •  ヒトT細胞膜抗原10D1の胸線内T細胞分化・活性化における役割の解析

    • Principal Investigator
      OBATA Tetsuji
    • Project Period (FY)
      1990 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      Juntendo University
  •  キラ-T細胞による腫瘍細胞の認識と破壊機構の解明

    • Principal Investigator
      奥村 康
    • Project Period (FY)
      1990 – 1992
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Juntendo University
  •  Molecular biological study on intercellular adhesion molecules involved in activation and differentiation of hematopoietic cells.Principal Investigator

    • Principal Investigator
      YAGITA Hideo
    • Project Period (FY)
      1990 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      Juntendo University School of Medicine
  •  キラー細胞による腫瘍細胞障害性とその誘導機序及びそれに対する抵抗性の分子的解析Principal Investigator

    • Principal Investigator
      八木田 秀雄
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Juntendo University
  •  HIV感染によるCD4陽性T細胞減少機序の分子免疫学的解析

    • Principal Investigator
      奥村 康
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Juntendo University
  •  Immuno-Melecular characterization of lymphocyte functioning antigen (LFA)

    • Principal Investigator
      OKUMURA Ko
    • Project Period (FY)
      1989 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      Juntendo University School of Medicine
  •  MHC非抱亜性キラー細胞による腫瘍の認識及び破壊機構の解明とその制癌への応用Principal Investigator

    • Principal Investigator
      八木田 秀雄
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Juntendo University
  •  Importance of CD2-LFA-3 interaction in differentiation and function of T and NK cells.Principal Investigator

    • Principal Investigator
      YAGITA Hideo
    • Project Period (FY)
      1988 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      Juntendo University School of Medicine
  •  マウス及びヒトT細胞白血病の転移におけるT細胞クロノタイプ及び分化抗原の転換

    • Principal Investigator
      奥村 康
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Juntendo University
  •  Immuno Molecular Analysis of Suppressor T cell receptor

    • Principal Investigator
      OKUMURA Ko
    • Project Period (FY)
      1986 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      Juntendo University

All 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Other

All Journal Article Presentation Book

  • [Book] 標準免疫学2013

    • Author(s)
      八木田秀雄
    • Total Pages
      459
    • Publisher
      医学書院
    • Data Source
      KAKENHI-PROJECT-22240089
  • [Book] 抗体を用いたがんに対する免疫応答の制御2009

    • Author(s)
      八木田秀雄
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-17016071
  • [Journal Article] SCIB2, an antibody DNA vaccine encoding NY-ESO-1 epitopes, induces potent antitumor immunity which is further enhaned by checkpoit blockade.2016

    • Author(s)
      Xue W, Metheringham RL, Brentville VA, Gunn B, Symonds P, Yagita H, Ramage JM, Durrant LG
    • Journal Title

      Oncoimmunology

      Volume: 5(6)

    • DOI

      10.1080/2162402x.2016.1169353

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26290059
  • [Journal Article] Radiation-induced enhancement of antitumor T cell immunity by VEGF-targeted 4-1BB costimulation.2016

    • Author(s)
      Schrand B, Verma B, Levay A, Patel S, Castro I, Benaduce AP, Brenneman R, Umland O, Yagita H, Gilboa E, Ishkanian AS
    • Journal Title

      Cancer Res

      Volume: 77(6) Pages: 1310-1321

    • DOI

      10.1158/0008-5472.can-16-2105

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26290059
  • [Journal Article] Systemic DC Activation Modulates the Tumor Microenvironment and Shapes the Long-Lived Tumor-Specific Memory Mediated by CD8+ T Cells.2016

    • Author(s)
      Shimizu K, Yamasaki S, Shinga J, Sato Y, Watanabe T, Ohara O, Kuzushima K, Yagita H, Komuro Y, Asakura M, Fujii S
    • Journal Title

      Cancer Res.

      Volume: 76(13) Pages: 3756-3766

    • DOI

      10.1158/0008-5472.can-15-3219

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26290059, KAKENHI-PROJECT-26430179, KAKENHI-PROJECT-15K09590
  • [Journal Article] Establishment of a therapeutic anti-pan HLA-class II monoclonal antibody that directly induces lymphoma cell death via large pore formation.2016

    • Author(s)
      Matsuoka S, Ishii Y, Nakao A, Abe M, Ohtsuji N, Momose S, Jin H, Arase H, Sugimoto K, Nakauchi Y, Masutani H, Maeda M, Yagita H, Komatsu N, Hino O
    • Journal Title

      PLoS One.

      Volume: 11

    • DOI

      10.1371/journal.pone.0150496

    • NAID

      120005838168

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15H04864, KAKENHI-PROJECT-25460386, KAKENHI-PROJECT-26670475, KAKENHI-PROJECT-15H02545, KAKENHI-PROJECT-15F15115, KAKENHI-PROJECT-26290059
  • [Journal Article] CD27 agonism plus PD-1 blockade recapitulates CD4+ T cell help in terapeutic anti-cancer vaccination.2016

    • Author(s)
      Ahrends T, Babala N, Xiao Y, Yagita H, van Eenennaam H, Borst J
    • Journal Title

      Cancer Res

      Volume: 印刷中

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26290059
  • [Journal Article] Agonistic CD40 mAb-driven IL-12 reverses resistance to anti-PD1 in a T cell-rich tumor.2016

    • Author(s)
      Ngiow SF, Young A, Blake SJ, Hill GR, Yagita H, Teng MW, Korman AJ, Smyth MJ
    • Journal Title

      Cancer Res

      Volume: 76(21) Pages: 6266-6277

    • DOI

      10.1158/0008-5472.can-16-2141

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26290059
  • [Journal Article] Combination anti-CTLA-4 and anti-RANKL in metastatic melanoma.2016

    • Author(s)
      Smyth MJ, Yagita H, McArthur GA
    • Journal Title

      J Clin Oncol

      Volume: 34(12)

    • DOI

      10.1200/jco.2013.51.3572

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26290059
  • [Journal Article] IL-17A-producing CD30(+) Vδ1 T cells drive inflammation-induced cancer progression2016

    • Author(s)
      Kimura Y, Nagai N, Tsunekawa N, Sato-Matsushita M, Yoshimoto T, Cua DJ, Iwakura Y, Yagita H, Okada F, Tahara H, Saiki I, Irimura T, Hayakawa Y.
    • Journal Title

      Cancer Sci

      Volume: 107 Pages: 1106-1214

    • DOI

      10.1111/cas.13005

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011, KAKENHI-PROJECT-15J11569, KAKENHI-PROJECT-25293011, KAKENHI-PROJECT-26290059, KAKENHI-PROJECT-26430158, KAKENHI-PROJECT-26460472, KAKENHI-PROJECT-15K07947, KAKENHI-PROJECT-15K08433, KAKENHI-PROJECT-15K08902, KAKENHI-PROJECT-26670023
  • [Journal Article] Protective Role of ICOS and ICOS Ligand in Corneal Transplantation and in Maintenance of Immune Privilege.2016

    • Author(s)
      Kunishige T, Taniguchi H, Terada M, Akiba H, Yagita H, Abe R, Hori J
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 57(15) Pages: 6815-6823

    • DOI

      10.1167/iovs.16-20644

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26462700, KAKENHI-PROJECT-15K20290, KAKENHI-PROJECT-16K09924
  • [Journal Article] The Notch ligand DLL4 defines a capability of human dendritic cells in regulating Th1 and Th17 differentiation.2016

    • Author(s)
      Meng L, Bai Z, He S, Mochizuki K, Purushe J, Sun H, Wang J, Yagita H, Mineishi S, Fung H, Yanik GA, Carcchio R, Fan X, Crisalli LM, Hexner EO, Reshef R, Zhang Y, Zhang Y
    • Journal Title

      J Immunol

      Volume: 196 Pages: 1070-1080

    • DOI

      10.4049/jimmunol.1501310

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26290059
  • [Journal Article] Tumor eradication by cisplatin is sustained by CD80/86-mediated costimulation of CD8+ T cells.2016

    • Author(s)
      Beyranvand Nejad E, van der Sluis TC, van Duikeren S, Yagita H, Janssen GM, van Veelen PA, Melief CJ, van der Burg SH, Arens R
    • Journal Title

      Cancer Res

      Volume: 76(29) Pages: 6017-6029

    • DOI

      10.1158/0008-5472.can-16-0881

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26290059
  • [Journal Article] Concomitant targeting of programmed death-1 (PD-1) and CD137 improves the efficacy of radiotherapy in a mouse model of human BRAFV600-mutant melanoma.2016

    • Author(s)
      Kroon P, Gadiot J, Peeters M, Gasparini A, Deken MA, Yagita H, Verheij M, Borst J, Blank CU, Verbrugge I
    • Journal Title

      Cancer Immunol Immunother

      Volume: 65(6) Pages: 753-763

    • DOI

      10.1007/s00262-016-1843-4

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26290059
  • [Journal Article] Agonists of the TRAIL death receptor DR5 sensitize intestinal stem cells to chemotherapy-induced cell death and trigger gastrointestinal toxicity.2016

    • Author(s)
      Finnberg, N. K., Gokare, P., Navaraj, A., Lang Luhs K. A., Cerniglia, G., Yagita, H., Takeda, K., Motoyama, N., and EL-Deiry, W. S.
    • Journal Title

      Cancer Res

      Volume: 76 Pages: 700-712

    • DOI

      10.1158/0008-5472.can-15-2759

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K14410, KAKENHI-PROJECT-26290059
  • [Journal Article] Differential contribution of three immune checkpoint (VISTA, CTLA-4, PD-1) pathways to antitumor responses against squamous cell carcinoma2016

    • Author(s)
      Kondo Y, Ohno T, Nishii N, Harada K, Azuma M
    • Journal Title

      Oral Oncol

      Volume: 57 Pages: 54-60

    • DOI

      10.1016/j.oraloncology.2016.04.005

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26253086, KAKENHI-PROJECT-26290059
  • [Journal Article] SCIB1, a huIgG1 antibody DNA vaccination, combined with PD-1 blockade induced efficient therapy of poorly immunogenic tumors.2016

    • Author(s)
      Xue W, Brentville VA, Symonds P, Cook KW, Yagita H, Metheringham RL, Durrant LG
    • Journal Title

      Oncotarget

      Volume: 7(50) Pages: 83088-83100

    • DOI

      10.18632/oncotarget.13070

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26290059
  • [Journal Article] CD27 agonism plus PD-1 blockade recapitulates CD4+ T cell help in therapeutic anti-cancer vaccination.2016

    • Author(s)
      Ahrends T, Babala N, Xiao Y, Yagita H, van Eenennaam H, Borst J
    • Journal Title

      Cancer Res

      Volume: 76(10) Pages: 2921-2931

    • DOI

      10.1158/0008-5472.can-15-3130

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26290059
  • [Journal Article] Notch controls the survival of memory CD4+ T cells by regulating glucose uptake.2015

    • Author(s)
      Maekawa Y, Ishifune C, Tsukumo S, Hozumi K, Yagita H, Yasutomo K.
    • Journal Title

      Nat Med

      Volume: 21 Pages: 55-61

    • DOI

      10.1038/nm.3758

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24590585, KAKENHI-PROJECT-26290059, KAKENHI-PROJECT-15K19131, KAKENHI-PLANNED-26110008, KAKENHI-PROJECT-26253063
  • [Journal Article] Rational conbination of immunotherapies with clinical efficacy in mice with advanced cancer.2015

    • Author(s)
      Bransi A, Camilo Salgado O, Beffinger M, Milo K, Silina K, Yagita H, Becher B, Knuth A, van den Broek M
    • Journal Title

      Cancer Immunol Res

      Volume: 3 Pages: 1279-1288

    • DOI

      10.1158/2326-6066.cir-15-0103-t

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26290059
  • [Journal Article] VEGF-A modulates expression of inhibitory checkpoints on CD8+ T cells in tumors.2015

    • Author(s)
      Voron T, Colussi O, Marcheteau E, Pernot S, Nizard M, Pointet A, Latreche S, Bergaya S, Benhamouda N, Tanchot C, Stockmann C, Combe P, Berger A, Zinzindohoue F, Yagita H, Tartour E, Taieb J, Terme M
    • Journal Title

      J Exp Med

      Volume: 212 Pages: 139-148

    • DOI

      10.1084/jem.20140559

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26290059
  • [Journal Article] Immunomodulatory effect of peritumorally administered interferon-beta on melanoma through tumor-associated macrophages.2015

    • Author(s)
      Kakizaki A, Fujimura T, Furudate S, Kambayashi Y, Yamauchi T, Yagita H, Aiba S
    • Journal Title

      Oncoimmunology

      Volume: 4

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26290059
  • [Journal Article] The PTEN pathway in Treg is a critical driver of the suppressive tumor microenvironment.2015

    • Author(s)
      Sharma MD, Shinde R, McGaha TL, Huang L, Holmgaard RB, Wolchok JD, Mautino MR, Celis E, Sharpe AH, Francisco LM, Powell JD, Yagita H, Mellor AL, Blazar BR, Munn DH
    • Journal Title

      Sci Adv

      Volume: 1

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26290059
  • [Journal Article] Combination immunotherapy with 4-1BB activation and PD-1 blockade enhances antitumor efficacy in a mouse model of subcutaneous tumor.2015

    • Author(s)
      Shindo Y, Yoshimura K, Kuramasu A, Watanabe Y, Ito H, Kondo T, Oga A, Ito H, Yoshino S, Hazama S, Tamada K, Yagita H, Oka M
    • Journal Title

      Anticancer Res

      Volume: 35 Pages: 129-136

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26290059
  • [Journal Article] Blockade of PD-1/PD-L1 promotes adoptive T-cell immunotherapy in a tolerogenic environment.2015

    • Author(s)
      Blake SJ, Ching AL, Kenna TJ, Galea R, Large J, Yagita H, Steptoe RJ
    • Journal Title

      PLoS One

      Volume: 10(3)

    • DOI

      10.1371/journal.pone.0119483

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26290059
  • [Journal Article] Bortezomib improves adoptive T cell therapy by sensitizing cancer cells to FasL cytotoxicity.2015

    • Author(s)
      Shanker A, Pellom ST, Dudimah DF, Thounaojam MC, de Kluiver RL, Brooks AD, Yagita H, McVicar DW, Murphy WJ, Longo DL, Sayers TJ
    • Journal Title

      Cancer Res

      Volume: 75 Pages: 5260-5272

    • DOI

      10.1158/0008-5472.can-15-0794

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26290059
  • [Journal Article] Thymus-derived regulatory T cells restrain pro-inflammatory Th1 responses by downregulating CD70 on dendritic cells.2015

    • Author(s)
      Dhainaut M, Coquerelle C, Uzureau S, Denoeud J, Acolty V, Oldenhove G, Galuppo A, Sparwasser T, Tielemans K, Pays E, Yagita H, Borst J, Moser M
    • Journal Title

      EMBO J

      Volume: 34 Pages: 1336-1348

    • DOI

      10.15252/embj.201490312

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26290059
  • [Journal Article] CD70 and IFN-1 selectively induce Eomesdermin or T-bet and synergize to promote CD8+ T-cell responses.2015

    • Author(s)
      Dong H, Franklin NA, Ritchea SB, Yagita H, Glennie MJ, Bullock TN
    • Journal Title

      Eur J Immunol

      Volume: 45 Pages: 3289-3301

    • DOI

      10.1002/eji.201445291

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26290059
  • [Journal Article] Hes1 suppresses acute myeloid leukemia development through FLT3 repression.2015

    • Author(s)
      Kato T, Sakata-Yanagimoto M, Nishikii H, Miyake Y, Yokayama Y, Asabe Y, Kamada Y, Ueno M, Obara N, Suzukawa K, Hasegawa Y, Kitabayashi I, Uchida K, Hirao A, Yagita H, Kageyama R, Chiba S
    • Journal Title

      Leukemia

      Volume: 29 Pages: 576-585

    • DOI

      10.1038/leu.2014.281

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24390241, KAKENHI-PUBLICLY-25112703, KAKENHI-PROJECT-25860778, KAKENHI-PROJECT-26290059
  • [Journal Article] Piperine enhances the efficacy ofTRAIL-based therapy of triple-negative breast cancer cells.2014

    • Author(s)
      Abdelhamad S, Yokoyama S, Refaat A, Ogura K, Yagita H, Awale S, Saiki I
    • Journal Title

      Anticancer Res

      Volume: 34 Pages: 1893-1899

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26290059
  • [Journal Article] ER stress regulates myeloid-derived suppressor cell fate through TRAIL-R-mediated apoptosis.2014

    • Author(s)
      Condamine T, Kumar V, Ramachandran IR, Youn J, Celis E, Finnberg N, El-Deiry WS, Winograd R, Vonderheide RH, English NR, Knight SC, Yagita H, McCaffrey JC, Antonia S, Hockstein N, Witt R, Masters G, Bauer T, Gabrilovich DI
    • Journal Title

      J Clin Invest

      Volume: 124 Pages: 2626-2639

    • DOI

      10.1172/jci74056

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26290059
  • [Journal Article] PD-1 blockade enhances T cell migration to tumors by elevating IFN-γ inducible chemokines2013

    • Author(s)
      Berrien-Elliott MM, Jackson SR, Meyer JM, Rouskey CJ, Nguyen TL, Yagita H, Greenberg P, Dipaolo RJ, Teague RM
    • Journal Title

      Cancer Res

      Volume: 73 Pages: 5209-5218

    • DOI

      10.1158/0008-5472.can-12-2179

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22240089
  • [Journal Article] The TWEAK receptor Fn14 is a therapeutic target in melanoma: Immunotoxins targeting Fn14 receptor for malignant melanoma treatment2013

    • Author(s)
      Zhou H, Ekmekcioglu S, Marks JW, Mohamedali KA, Asrani K, Phillips KK, Brown SA, Cheng E, Weiss MB,Hittelman WN, Tran NL, Yagita H, Winkles JA, Rosenblum MG
    • Journal Title

      J Invest Dermatol

      Volume: 133 Pages: 1052-1062

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22240089
  • [Journal Article] Simultaneous blockade of programmed death 1 and vascular endothelial growth factor receptor 2 (VEGFR2) induces synergistic anti-tumor effect in vivo2013

    • Author(s)
      Yasuda S
    • Journal Title

      Clin Exp Immunol

      Volume: 172 Pages: 500-506

    • DOI

      10.1111/cei.12069

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390366, KAKENHI-PROJECT-22240089, KAKENHI-PROJECT-24591887
  • [Journal Article] Combined blockade of TIM-3 and TIM-4 augments cancer vaccine efficacy against established melanomas.2013

    • Author(s)
      Baghdadi M, Nagao H, Yoshiyama H, Akiba H, Yagita H, Dosaka-Akita H, Jinushi M
    • Journal Title

      Cancer Immunology and Immunotherapy

      Volume: 62 Pages: 629-37

    • DOI

      10.1007/s00262-012-1371-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22240089, KAKENHI-PUBLICLY-23130501, KAKENHI-PROJECT-23501283, KAKENHI-PROJECT-23590534, KAKENHI-PUBLICLY-25112701, KAKENHI-PUBLICLY-25130701, KAKENHI-PROJECT-25461503
  • [Journal Article] Galectin-9-mediated protection from allo-specific T cells as a mechanism of immune privilege of corneal allografts2013

    • Author(s)
      Shimmura-Tomita M, Wang M, Taniguchi H, Akiba H, Yagita H, Hori J.
    • Journal Title

      PLoS One

      Volume: 8 (5)

    • DOI

      10.1371/journal.pone.0063620

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592619, KAKENHI-PROJECT-25461503
  • [Journal Article] Host immunity contributes to the anti-melanoma activity of BRAF inhibitors.2013

    • Author(s)
      Knight DA, Ngiow SF, Li M, Parmenter T, Mok S, Cass A, Haynes NM, Kinross K, Yagita H, Koya RC, Greber TG, Ribas A, McArthur GA, Smyth MJ
    • Journal Title

      J Cin Invest

      Volume: 123 Pages: 1371-1381

    • DOI

      10.1172/jci66236

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22240089
  • [Journal Article] Galectin-9-mediated protection from allo-specific T cells as a mechanism of immune privilege of corneal allografts2013

    • Author(s)
      Machiko Shimmura-Tomita, Mingcong Wang, Hiroko Taniguchi, Hisaya Akiba, Hideo Yagita and Junko Hori.
    • Journal Title

      PLOS ONE

      Volume: -

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592619
  • [Journal Article] Induction of pro-apoptotic antibodies to triple negative breast cancer by vaccination with TRAIL death receptor DR5 DNA.2012

    • Author(s)
      Piechocki MP, Wu GS, Jones RF, Jacob JB, Gibson H, Ethier SP, Abrams1 J, Yagita H, Venuprasad K, Wei WZ
    • Journal Title

      Int J Cancer

      Volume: 131 Pages: 2562-2572

    • DOI

      10.1002/ijc.27534

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22240089
  • [Journal Article] Epigenetic modulation enhances the therapeutic effect of anti-IL13Ralpha 2 antibody in human mesothelioma xenografts2012

    • Author(s)
      Takenouchi M, Hirai S, Sakuragi N, Yagita H, Hamada H, Kato K
    • Journal Title

      Clinical Cancer Research

      Volume: 17 Pages: 2819-2829

    • DOI

      10.1158/1078-0432.ccr-10-2986

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22240089, KAKENHI-PROJECT-22390118
  • [Journal Article] Radiotherapy promotes tumor-specific effector CD8+ T cells via dendritic cell activation.2012

    • Author(s)
      Gupta A, Probst HC, Vuong V, Landshammer A, Muth S, Yagita H, Schwendener R, Pruschy M, Knuth A, van den Broek M
    • Journal Title

      J Immunol

      Volume: 189 Pages: 558-566

    • DOI

      10.4049/jimmunol.1200563

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22240089
  • [Journal Article] Polyfunctional CD4+ T cells are essential for eradicating advanced B-cell lymphoma after chemotherapy.2012

    • Author(s)
      Ding ZC, Huang L, Blazar BR, Yagita H, Mellor AL, Munn DH, Zhou G
    • Journal Title

      Blood

      Volume: 120 Pages: 2229-2239

    • DOI

      10.1182/blood-2011-12-398321

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22240089
  • [Journal Article] Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1.2012

    • Author(s)
      Chiba, M. Baghdadi, H. Akiba, H. Yoshiyama, I. Kinoshita, H. Dosaka-Akita, Y. Fujioka, Y. Ohba, J. V. Gorman, J. D. Colgan, M. Hirashima, T. Uede, A. Takaoka, H. Yagita and M. Jinushi.
    • Journal Title

      Nature Immunology

      Volume: 13 Pages: 832-42

    • DOI

      10.1038/ni.2376

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J04616, KAKENHI-PROJECT-21390113, KAKENHI-PROJECT-22240089, KAKENHI-PROJECT-22590360, KAKENHI-PROJECT-22591098, KAKENHI-PROJECT-23390090, KAKENHI-PROJECT-23501283, KAKENHI-PROJECT-23590534, KAKENHI-PROJECT-23591132, KAKENHI-PROJECT-23659196, KAKENHI-PUBLICLY-23114501
  • [Journal Article] Cancer-induced immunosuppression: IL-18-elicited immunoablative NK cells.2012

    • Author(s)
      Terme M, Ullrich E, Aymeric L, Meinhardt K, Coudert J, Desbois M, Ghiringhelli F, Viaud S, Ryffel B, Yagita H, Chen L, Mecheri S, Kaplanski G, Prevost-Blondel A, Kato M, Schultze JL, Tartour E, Kroemer G, Degli-Esposti M, Chaput N, Zitvogel L
    • Journal Title

      Cancer Res

      Volume: 72 Pages: 2757-2767

    • DOI

      10.1158/0008-5472.can-11-3379

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22240089, KAKENHI-PROJECT-23650241, KAKENHI-PROJECT-24390157, KAKENHI-PROJECT-24406002
  • [Journal Article] Aging-associated B7-DC(+) B cells enhance anti-tumor immunity via Th1 and Th17 induction.2012

    • Author(s)
      Tomihara K, Shin T, Hurez VJ, Yagita H, Pardoll DM, Zhang B, Curiel TJ, Shin T
    • Journal Title

      Aging Cell

      Volume: 11 Pages: 128-138

    • DOI

      10.1111/j.1474-9726.2011.00764.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22240089, KAKENHI-PROJECT-23890069
  • [Journal Article] ATM-mediated DNA damage signals suppress antitumor immunity by integrin-αvβ3-dependent mechanisms2012

    • Author(s)
      Jinushi M
    • Journal Title

      Cancer Research

      Volume: 72 Pages: 56-65

    • DOI

      10.1158/0008-5472.can-11-2028

    • NAID

      120005090590

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390113, KAKENHI-PROJECT-21689031, KAKENHI-PROJECT-22240089, KAKENHI-PUBLICLY-23130501, KAKENHI-PROJECT-23590534, KAKENHI-PROJECT-23591132
  • [Journal Article] Radiotherapy increases the permissiveness of established mammary tumors to rejection by immunomodulatory antibodies.2012

    • Author(s)
      Verbrugge I, Hagekyriakou J, Sharp LL, Galli M, West AC, McLaughlin NM, Duret H, Yagita H, Johnstone RW, Smyth MJ, Haynes NM
    • Journal Title

      Cancer Res

      Volume: 72 Pages: 3163-3174

    • DOI

      10.1158/0008-5472.can-12-0210

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22240089
  • [Journal Article] The CD4+ T-cell help signal is transmitted from APC to CD8+ T-cells via CD27-CD70 interactions.2012

    • Author(s)
      Feau S, Garcia Z, Arens R, Yagita H, Borst J, Schoenberger SP
    • Journal Title

      Nat Commun

      Volume: 3 Pages: 948-948

    • DOI

      10.1038/ncomms1948

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22240089
  • [Journal Article] Anti-tumor activities and on-target toxicities mediated by TRAIL receptor agonist following co-treatment with panobinostat2011

    • Author(s)
      Martin BP, J Frew A, Bots M, Fox S, Long F, Takeda K, Yagita H, Atadja P, Smyth MJ, Johnstone RW
    • Journal Title

      Int J Cancer

      Volume: 128 Pages: 2735-2747

    • DOI

      10.1002/ijc.25594

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22240089
  • [Journal Article] Tumor-associated macrophages regulate tumorigenicity and anticancer drugresponses of cancer stem/initiating cells2011

    • Author(s)
      Jinushi M, Chiba S, Yoshiyama H, Masutomi K, Kinoshita I, Dosaka-Akita H, Yagita H, Takaoka A, Tahara H.
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 108巻 Pages: 112425-12430

    • DOI

      10.1073/pnas.1106645108

    • NAID

      10030575946

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249069, KAKENHI-PROJECT-21689031, KAKENHI-PROJECT-22240089, KAKENHI-PUBLICLY-23130501, KAKENHI-PROJECT-23590534, KAKENHI-PROJECT-23591132
  • [Journal Article] Combination of lentivector immunization and low dose chemotherapy or PD-1/PD-L1 blocking primes self-reactive T cells and induces anti-tumor immunity2011

    • Author(s)
      Sierro SR, Donda A, Perret R, Guillaume P, Yagita H, Levy F, Romero P
    • Journal Title

      Eur J Immunol

      Volume: 41 Pages: 2217-2228

    • DOI

      10.1002/eji.201041235

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22240089
  • [Journal Article] TLR2-dependent induction of IL-10 and Foxp3+CD25+CD4+ regulatory T cells prevents effective anti-tumor immunity induced by Pam2 lipopeptides in vivo2011

    • Author(s)
      Yamazaki, S., K. Okada, A. Maruyama, M. Matsumoto, and T. Seya.
    • Journal Title

      PLoS ONE

      Volume: 6(4)

    • DOI

      10.1371/journal.pone.0018833

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22114008, KAKENHI-PROJECT-22240089, KAKENHI-PROJECT-23390088, KAKENHI-PROJECT-23390120, KAKENHI-PROJECT-23590558
  • [Journal Article] Therapeutic potential of the TWEAK/Fn14 pathway in intractable gastrointestinal cancer2011

    • Author(s)
      Yoriki R, Akashi S, Sho M, Nomi T, Yamato I, Hotta K, Takayama T, Matsumoto S, Wakatsuki K, Migita K, Yagita H, Nakajima Y
    • Journal Title

      Exp Ther Med

      Volume: 2 Pages: 103-108

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/22977477

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22240089
  • [Journal Article] FOXO3 programs tumor-associated DCs to become tolerogenic in human and murine prostate cancer2011

    • Author(s)
      Watkins SK, Zhu Z, Riboldi E, Shafer-Weaver KA, Stagliano KE, Sklavos MM, Ambs S, Yagita H, Hurwitz AA
    • Journal Title

      J Clin Invest

      Volume: 121 Pages: 1361-1372

    • DOI

      10.1172/jci44325

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22240089
  • [Journal Article] Anti-TIM3 antibody promotes T cell IFN-gamma-mediated antitumor immunity and suppresses established tumors2011

    • Author(s)
      Ngiow SF, von Scheidt B, Akiba H, Yagita H, Teng MW, Smyth MJ
    • Journal Title

      Cancer Res

      Volume: 71 Pages: 3540-3551

    • DOI

      10.1158/0008-5472.can-11-0096

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22240089, KAKENHI-PROJECT-22591098
  • [Journal Article] Development and characterization of a potent immunoconjugate targeting the Fn14 receptor on solid tumor cells2011

    • Author(s)
      Zhou H, Marks JW, Hittelman WN, Yagita H, Cheung LH, Rosenblum MG, Winkles JA
    • Journal Title

      Mol Cancer Ther

      Volume: 10 Pages: 1276-1288

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22240089
  • [Journal Article] Importin-β-mediated nuclear localization of death receptor 5 (DR5) limits DR5/TNF-related-apoptosis inducing ligand (TRAIL)-induced cell death of human tumor cells2011

    • Author(s)
      Kojima Y, Nakayama M, Nishina T, Nakano H, Koyanagi M, Takeda K, Okumura K, Yagita H
    • Journal Title

      JOURNAL OF BIOLOGICAL CHEMISTRY

      Volume: 286 Pages: 43383-43393

    • DOI

      10.1074/jbc.m111.309377

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22240089, KAKENHI-PUBLICLY-23112519, KAKENHI-PUBLICLY-23117717, KAKENHI-PROJECT-23300355, KAKENHI-PROJECT-23390260, KAKENHI-PROJECT-23659404
  • [Journal Article] IL-18 induces PD-1-dependent immunosuppression in cancer.2011

    • Author(s)
      Terme M, Ullrich E, Aymeric L, Meinhardt K, Desbois M, Delahaye NF, Viaud S, Ryffel B, Yagita H, Kaplanski G, Prevost-Blondel A, Kato M, Schultze JL, Tartour E, Kroemer G, Chaput N, Zitvogel L
    • Journal Title

      Cancer Res.

      Volume: 71 Pages: 5412-5422

    • DOI

      10.1158/0008-5472.can-11-0993

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22240089, KAKENHI-PROJECT-23650241
  • [Journal Article] Anti-ErbB-2 mAb therapy requires type I and II interferons and synergizes with anti-PD-1 or anti-CD137 mAb therapy2011

    • Author(s)
      Stagg J, Loi S, Divisekera U, Ngiow SF, Duret H, Yagita H, Teng MW, Smyth MJ
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 108 Pages: 7142-7147

    • DOI

      10.1073/pnas.1016569108

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22240089
  • [Journal Article] PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors2010

    • Author(s)
      Sakanishi T, Yagita H
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 393 Pages: 4275-4280

    • DOI

      10.1016/j.bbrc.2010.02.092

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22240089
  • [Journal Article] Blockade of programmed death-1 pathway rescues the effector function of tumor-infiltrating T cells and enhances the antitumor efficacy of lentivector immunization2010

    • Author(s)
      Zhou Q, Xiao H, Liu Y, Peng Y, Hong Y, Yagita H, Chandler P, Munn DH, Mellor A, Fu N, He Y
    • Journal Title

      J Immunol

      Volume: 185 Pages: 5082-5092

    • DOI

      10.4049/jimmunol.1001821

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22240089
  • [Journal Article] Tumor-reactive CD4+ T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts.2010

    • Author(s)
      Quezada SA, Simpson TR, Peggs KS, Merghoub T, Vider J, Fan X, Blasberg R, Yagita H, Muranski P, Antony PA, Restifo NP, Allison JP
    • Journal Title

      J Exp Med 207

      Pages: 637-650

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016071
  • [Journal Article] Notch2 signaling is required for potent antitumor immunity in vivo2010

    • Author(s)
      Sugimoto K, Maekawa Y, Kitamura A, Nishida J, Koyanagi A, Yagita H, Kojima H, Chiba S, Shimada M, Yasutomo K
    • Journal Title

      J Immunol

      Volume: 184 Pages: 4673-4678

    • DOI

      10.4049/jimmunol.0903661

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20679005, KAKENHI-PROJECT-21590536, KAKENHI-PROJECT-22240089
  • [Journal Article] PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors.2010

    • Author(s)
      Curran MA, Montalvo W, Yagita H, Allison JP
    • Journal Title

      Proc Natl Acad Sci USA 107

      Pages: 4275-4280

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016071
  • [Journal Article] Optimized combination therapy using bortezomib, TRAIL and TLR agonists in established breast tumors2010

    • Author(s)
      Lee S, Yagita H, Sayers TJ, Celis E
    • Journal Title

      Cancer Immunol Immunother

      Volume: 59 Pages: 1073-1081

    • DOI

      10.1007/s00262-010-0834-0

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22240089
  • [Journal Article] Targeting antigen to diverse APCs inactivates memory CD8+ T cells without eliciting tissue-destructive effector function.2010

    • Author(s)
      Kenna TJ, Waldie T, McNally A, Thomson M, Yagita H, Thomas R, Steptoe RJ
    • Journal Title

      J Immunol 184

      Pages: 598-606

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016071
  • [Journal Article] Spatiotemporal basis of CTLA-4 costimulatory molecule-mediated negative regulation of T cell activation2010

    • Author(s)
      Yokosuka T, Kobayashi W, Takamatsu M, Sakata-Sogawa K, Zeng H, Yagita H, Tokunaga M, Saito T
    • Journal Title

      Immunity

      Volume: Vol.33 Pages: 326-339

    • DOI

      10.1016/j.immuni.2010.09.006

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20114004, KAKENHI-PROJECT-22240089
  • [Journal Article] Anti-tumor effects of depleting and non-depleting anti-CD27 monoclonal antibodies in immune-competent mice.2010

    • Author(s)
      Sakanishi T, Yagita H
    • Journal Title

      Biochem Biophys Res Commun 393

      Pages: 829-835

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016071
  • [Journal Article] Blockade of delta-like ligand 4 signaling inhibits both growth and angiogenesis of pancreatic cancer2010

    • Author(s)
      Oishi H, Sunamura M. Egawa S, Motoi F, Unno M, Furukawa T, Habib NA, Yagita H
    • Journal Title

      Pancreas

      Volume: 39 Pages: 897-903

    • DOI

      10.1097/mpa.0b013e3181ce7185

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22240089, KAKENHI-PROJECT-22390253, KAKENHI-PROJECT-22591512
  • [Journal Article] DNAM-1/CD155 interactions promote cytokine NK cell-mediated suppression of poorly immunogenic melanoma metastasis.2010

    • Author(s)
      Chan CJ, Andrew DM, McLaughlin NM, Yagita H, Gilfillan S, Colonna M, Smyth MJ
    • Journal Title

      J Immunol 184

      Pages: 902-911

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016071
  • [Journal Article] Darcy PK, Smyth MJ: CD11c+ dendritic cells and B cells contribute to the tumoricidal activity of anti-DR5 antibody therapy in established tumors2010

    • Author(s)
      Haynes NM, Hawkins ED, Li M, McLaughlin NM, Hammerling GJ, Schwendener R, Winoto A, Wensky A, Yagita H, Takeda K, Kershaw MH
    • Journal Title

      J Immunol

      Volume: 185 Pages: 532-541

    • DOI

      10.4049/jimmunol.0903624

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22240089
  • [Journal Article] DNAM-1/CD155 interactions promote cytokine NK cell-mediated suppression of poorly immunogenic melanoma metastasis2010

    • Author(s)
      Chan CJ, Andrew DM, McLaughlin NM, Yagita H, Gilfillan S, Colonna M, Smyth MJ
    • Journal Title

      J Immunol

      Volume: 184 Pages: 902-911

    • DOI

      10.4049/jimmunol.0903225

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22240089
  • [Journal Article] Control of established melanoma by CD27 stimulation is associated with enhanced effector function and persistence,and reduced PD-1 expression of tumor infiltrating CD8+ T cells2010

    • Author(s)
      Roberts DJ, Franklin NA, Kingeter LM, Yagita H, Tutt AL, Glennie MJ, Bullock TN
    • Journal Title

      J Immunother

      Volume: 33 Pages: 769-779

    • DOI

      10.1097/cji.0b013e3181ee238f

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22240089
  • [Journal Article] Peptide vaccine induces enhanced tumor growth associated with apoptosis induction in CD8+ T cells2010

    • Author(s)
      Muraoka D, Kato T, Wang L, Maeda Y, Noguchi T, Harada N, Takeda K, Yagita H, Guillaume P, Luescher I, Old LJ, Shiku H, Nishikawa H
    • Journal Title

      J Immunol

      Volume: 185 Pages: 3768-3776

    • DOI

      10.4049/jimmunol.0903649

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22240089
  • [Journal Article] Optimized combination therapy using bortezomib, TRAIL and TLR agonists in established breast tumors.2010

    • Author(s)
      Lee S, Yagita H, Sayers TJ, Celis E
    • Journal Title

      Cancer Immunol Immunother (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016071
  • [Journal Article] Tumor-reactive CD4+ T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts2010

    • Author(s)
      Quezada SA, Simpson TR, Peggs KS, Merghoub T, Vider J, Fan X, Blasberg R, Yagita H, Muranski P, Antony PA, Restifo NP, Allison JP
    • Journal Title

      J Exp Med

      Volume: 207 Pages: 637-650

    • DOI

      10.1084/jem.20091918

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22240089
  • [Journal Article] Combination therapy of established tumors by antibodies targeting immune activating and suppressing molecules2010

    • Author(s)
      Takeda K, Kojima Y, Uno T, Hayakawa Y, Teng MWL, Yoshizawa H, Yagita H, Geyjo F, Okumura K, Smyth MJ
    • Journal Title

      J Immunol

      Volume: 184 Pages: 5493-5501

    • DOI

      10.4049/jimmunol.0903033

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22240089
  • [Journal Article] Antigen presented by tumors in vivo determines the nature of CD8+ T cell cytotoxicity.2009

    • Author(s)
      Shanker A, Brooks AD, Jacobsen KM, Wine JW, Wiltrout RH, Yagita H, Sayers TJ
    • Journal Title

      Cancer Res 69

      Pages: 6615-6623

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016071
  • [Journal Article] PD-1/PD-L blockade prevents anergy induction and enhances the anti-tumor activities of glycolipid-activated invariant NKT cells.2009

    • Author(s)
      Parekh VV, Lalani S, Kim S, Halder R, Azuma M, Yagita H, Kumar V, Wu L, Kaer LV
    • Journal Title

      J Immunol 182

      Pages: 2816-2826

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016071
  • [Journal Article] NKG2A inhibits invariant NKT cell activation in hepatic injury.2009

    • Author(s)
      Kawamura T, Takeda K, Kaneda H, Matsumoto H, Hayakawa Y, Raulet DH, Ikarashi Y, Kronenberg M, Yagita H, Kinoshita K, Abo T, Okumura K, Smyth MJ
    • Journal Title

      J Immunol 182

      Pages: 250-258

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016071
  • [Journal Article] Clinical importance of B7-H3 expression in human pancreatic cancer.2009

    • Author(s)
      Yamato I, Sho M, Nomi T, Akahori T, Shimada K, Hotta K, Kanehiro H, Konishi N, Yagita H, Nakajima Y
    • Journal Title

      Br J Cancer 101

      Pages: 1709-1716

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016071
  • [Journal Article] Recall responses by helpless memory CD8+ T cells are restricted by the up-regulation of PD-1.2009

    • Author(s)
      Fuse S, Tsai C, Molloy MJ, Allie SR, Zhang W, Yagita H, Usherwood EJ
    • Journal Title

      J Immunol 182

      Pages: 4244-4254

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016071
  • [Journal Article] Blockade of B7-H1 or B7-DC induces an anti-tumor effect in a mouse pancreatic cancer model.2009

    • Author(s)
      Okudaira K, Hokari R, Tsuzuki Y, Okada Y, Komoto S, Watanabe C, Kurihara C, Kawaguchi A, Nagao S, Azuma M, Yagita H, Miura S
    • Journal Title

      Int J Oncol 35

      Pages: 741-749

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016071
  • [Journal Article] Tim-3 mediates phagocytosis of apoptotic cells and the cross-presentation.2009

    • Author(s)
      Nakayama M, Akiba H, Takeda K, Kojima Y, Hashiguchi M, Azuma M, Yagita H, Okumura K
    • Journal Title

      Blood 113

      Pages: 3821-3830

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016071
  • [Journal Article] Antibodies targeted to TRAIL receptor-2 and ErbB-2 synergize in vivo and induce an antitumor immune response.2008

    • Author(s)
      Stagg J, Sharkey J, Pommey S, Young R, Takeda K, Yagita H, Johnstone RW, Smyth MJ
    • Journal Title

      Proc Natl Acad Sci USA 105

      Pages: 16254-16259

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016071
  • [Journal Article] CD4+CD25+ Tregs control the TRAIL-dependent cytotoxicity of tumor-infiltrating DCs in rodent models of colon cancer.2008

    • Author(s)
      Roux S, Apetoh L, Chalmin F, Ladoire S, Mignot G, Puig PE, Lauvau G, Zitvogel L, Martin F, Chauffert B, Yagita H, Solary E, Ghiringhelli F
    • Journal Title

      J Clin Invest 118

      Pages: 3751-3761

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016071
  • [Journal Article] Watanabe Blockade of NKG2D signaling prevents the development of murine CD4+ T cell-mediated colitis2008

    • Author(s)
      Ito, Y., T., Kanai, T., Totsuka, R., Okamoto, K., Tsuchiya, Y., Nemoto, A., Yoshioka, T., Tomita, T., Nagaishi, N., Sakamoto, T., Sakanishi, K., Okumura, H., Yagita, M
    • Journal Title

      American journal of physiology 294

      Pages: 199-207

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390292
  • [Journal Article] Combination therapy of established cancer using a histone deacetylase inhibitor and a TRAIL receptor agonisit.2008

    • Author(s)
      Frew AJ, Lindemann RK, Martin BP, Clarke CJP, Sharkey J, Anthony DA, Banks KM, Haynes NM, Gangatirkar P, Stanley K, Bolden JE, Takeda K, Yagita H, Secrist JP, Smyth MJ, Johnstone RW
    • Journal Title

      Proc Natl Acad Sci USA 105

      Pages: 11317-11322

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016071
  • [Journal Article] Interleukin 21 enhances antibody-mediated tumor rejection.2008

    • Author(s)
      Smyth MJ, Teng MWL, Sharkey J, Westwood JA, Haynes NM, Yagita H, Takeda K, Sivakumar PV, Kershaw MH
    • Journal Title

      Cancer Res 68

      Pages: 3019-3025

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016071
  • [Journal Article] Dendritic cell-mediated NK cell activation is controlled by Jagged2-Notch interaction.2008

    • Author(s)
      Kijima M, Yamaguchi T, Isifune C, Maekawa Y, Koyanagi A, Yagita H, Chiba S, Kishihara K, Shimada M, Yasutomo K
    • Journal Title

      Proc Natl Acad Sci USA 105

      Pages: 7010-7015

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016071
  • [Journal Article] Differential effector mechanisms induced by vaccination with MUC1 DNA in the rejection of colon carcinoma growth at orthotopic sites and metastases.2008

    • Author(s)
      Sugiura D, Aida S, Denda-Nagai K, Takeda K, Kamata-Sakurai M, Yagita H, Irimura T
    • Journal Title

      Cancer Sci 99

      Pages: 2477-2484

    • NAID

      10024014429

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016071
  • [Journal Article] Programmed death-1/programmed death ligand 1 interaction regulates the induction and maintenance of invariant NKT cell anergy.2008

    • Author(s)
      Chang WS, Kim JY, Kim YJ, Kim YS, Lee JM, Azuma M, Yagita H, Kang CY
    • Journal Title

      J Immunol 181

      Pages: 6707-6710

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016071
  • [Journal Article] Combination of treatment with death receptor 5-specific antibody with therapeutic HPV DNA vaccination generates enhanced therapeutic anti-tumor effects.2008

    • Author(s)
      Tseng CW, Trimble C, Monie C, Alvarez RD, Huh WK, Buchsbaum DJ, Straughn JM, Wang MC, Yagita H, Hung CF, Wu TC
    • Journal Title

      Vaccine 26

      Pages: 4314-4319

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016071
  • [Journal Article] Death receptor 5-mediated apoptosis contributes to cholestatic liver disease.2008

    • Author(s)
      Takeda K, Kojima Y, Ikejima K, Harada K, Yamashina S, Okumura K, Aoyama T, Frese F, Ikeda H, Haynes NM, Cretney E, Yagita H, Sueyoshi N, Sato N, Nakanuma Y, Smyth MJ, Okumura K
    • Journal Title

      Proc Natl Acad Sci USA 105

      Pages: 10895-10900

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016071
  • [Journal Article] Notch2 integrates signaling by the transcriptional factors RBP-J and CREB1 to promote T cell cytotoxicity.2008

    • Author(s)
      Maekawa Y, Minato Y, Ishifune C, Kurihara T, Kitamura A, Kojima H, Yagita H, Sakata-Yanagimoto M, Saito T, Taniuchi I, Chiba S, Sone S, Yasutomo K
    • Journal Title

      Nature Immunol 9

      Pages: 1140-1147

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016071
  • [Journal Article] Downregulation of c-FLIP promotes caspase-dependent JNK activation and reactive oxygen species accumulation in tumor cells2008

    • Author(s)
      Nakajima, A., Y., Kojima, M., Nakayama, H., Yagita, K., Okumura, H., Nakano
    • Journal Title

      Oncogene 27

      Pages: 76-84

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390292
  • [Journal Article]2008

    • Author(s)
      Takeda K, Kojima Y, Ikejima K, Harada K, Yamashina S, Okumura K, Aoyama T, Fress S, Ikeda H, Hynes NM, Cretney E, Yagita H, Sueyoshi N, Sato N, Nakanuma Y, Smyth MJ, Okumura K
    • Journal Title

      Proc Natl Sci USA 105(31)

      Pages: 10895-10900

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590257
  • [Journal Article] Treating metastatic solid tumors with bortezomib and a tumor necrosis factor-related apoptosis-inducing ligand receptor agonist antibody.2008

    • Author(s)
      Shanker A, Brooks AD, Tristan CA, Wine JW, Elliot PJ, Yagita H, Takeda K, Smyth MJ, Murphy WJ, Sayers TJ
    • Journal Title

      J. Natl. Cancer Inst 100

      Pages: 649-662

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016071
  • [Journal Article] Death receptor 5 mediated-apoptosis contributes to cholestatic liver disease.2008

    • Author(s)
      Takeda K, Kojima Y, Ikejima K, Harada K, Yamashina S, Okumura K, Aoyama T, Frese s, Ikeda H, Hynes NM, Cretney E, Yagita H, Sueyoshi N, Sato N, Nakanuma Y, Smyth MJ, Okumura K
    • Journal Title

      Proc Natl Acad Sci U S A 105(31)

      Pages: 10895-10900

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590257
  • [Journal Article] Targeting death-inducing receptors in cancer therapy2007

    • Author(s)
      Takeda, K., J., Stagg, H., Yagita, K., Okumura, M. J., Smyth
    • Journal Title

      Oncogene 26

      Pages: 3745-3757

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390292
  • [Journal Article] A subset of dendritic cells induces CD4+ T cells to produce IFN-□by an IL-12-independent but CD70-dependent mechanism in vivo.2007

    • Author(s)
      Soares H, Waechter H, Glaichenhaus N, Mougneau E, Yagita H, Mizenina O, Dudziak D, Nussenzweig MC, Steinman RM
    • Journal Title

      J Exp Med 204

      Pages: 1095-1106

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016071
  • [Journal Article] Priming of CD8+ T cell responses by pathogens typically depends on CD70-mediated interactions with dendritic cells.2007

    • Author(s)
      Schildknecht A, Miescher I, Yagita H, van den Broek M
    • Journal Title

      Eur J Immunol 37

      Pages: 716-728

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016071
  • [Journal Article] Antibodies to T-cell Ig and mucin domain-containing proteins(Tim)-1 and -3 suppress the induction and progression of murine allergic conjunctivitis2007

    • Author(s)
      Fukushima, A., T., Sumi, K., Fukuda, N., Kumagai, T., Nishida, H., Akiba, K., Okumura, H., Yagita, H., Ueno
    • Journal Title

      Biochemical and biophysical research communications 353

      Pages: 211-216

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390292
  • [Journal Article] Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function.2007

    • Author(s)
      Xiao S, Najafian N, Reddy J, Albin M, Zhu C, Jensen E, Imitola J, Korn T, Anderson AC, Zhang Z, Gutierrez C, Moll T, Sobel RA, Umetsu DT, Yagita H, Akiba H, Strom T, Sayegh MH, DeKruyff RH, Khoury SJ, Kuchroo VK
    • Journal Title

      J Exp Med 204

      Pages: 1691-1702

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016071
  • [Journal Article] Tageting death-inducing receptors in cancer therapy.2007

    • Author(s)
      Takeda K, Stagg J, Yagita H, Okumura K, Smyth MJ
    • Journal Title

      Oncogene 26

      Pages: 3745-3757

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016071
  • [Journal Article] Clinical significance and therapeutic potential of the programmed death-1 ligand/programmed death-1 pathway in human pancreatic cancer.2007

    • Author(s)
      Nomi T, Sho M, Akahori T, Hamada K, Kubo A, Kanehiro H, Nakamura S, Enomoto K, Yagita H, Azuma M, Nakajima Y
    • Journal Title

      Clin Cancer Res 13

      Pages: 2151-2157

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016071
  • [Journal Article] Combined TLR/CD40 stimulation mediates potent immunity by regulating dendritic cell expression of CD70 in vivo.2007

    • Author(s)
      Sanchez PJ, McWilliams JA, Haluszczak C, Yagita H, Kedl RM
    • Journal Title

      J Immunol 178

      Pages: 1564-1572

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016071
  • [Journal Article] T-cell Ig and mucin domain-containing protein(Tim)-2 regulates murine allergic conjunctivitis during the effector phase2007

    • Author(s)
      Fukushima, A., T., Sumi, K., Fukuda, N., Kumagai, T., Nishida, K., Okumura, H., Akiba, H., Yagita, H., Ueno
    • Journal Title

      Immunology letters 110

      Pages: 133-138

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390292
  • [Journal Article] Blockade of the OX40ligand prolongs corneal allograft survival2007

    • Author(s)
      Hattori, T., Y., Usui, Y., Okunuki, Y., Sonoda, M., Usui, E., Takada, J., Mizuguchi, H., Yagita, K., Okumura, H., Akiba, M., Takeuchi
    • Journal Title

      European journal of immunology 37

      Pages: 3597-3604

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390292
  • [Journal Article] Perforin activity and immune homeaostasis: the common A91V polymorphism in perforin results in both pre- and post-synaptic defects in function.2007

    • Author(s)
      Voskoboinik I, Sutton VR, Ciccone A, House C, Chia J, Darcy PK, Yagita H, Trapani JA
    • Journal Title

      Blood 110

      Pages: 1184-1190

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016071
  • [Journal Article] B7-H3 regulates the development of experimental allergic conjunctivitis in mice2007

    • Author(s)
      Fukushima, A., T., Sumi, K., Fukuda, N., Kumagai, T., Nishida, T., Yamazaki, H., Akiba, K., Okumura, H., Yagita, H., Ueno
    • Journal Title

      Immunology letters 113

      Pages: 52-57

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390292
  • [Journal Article] Combined natural killer T-cell-based immunotherapy eradicates established tumors in mice.2007

    • Author(s)
      Teng MWL, Westwood JA, Darcy PK, Sharkey J, Tsuji M, Franck RW, Porcelli SA, Besra GS, Takeda K, Yagita H, Kershaw MH, Smyth MJ
    • Journal Title

      Cancer Res 67

      Pages: 7495-7504

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016071
  • [Journal Article] TNF receptor-associated factor 2-dependent canonical pathway is crucial for the development of Peyer's patches2007

    • Author(s)
      Piao, J. H., H., Yoshida, W. C., Yeh, T., Doi, X., Xue, H., Yagita, K., Okumura, H., Nakano
    • Journal Title

      J lmmunol 178

      Pages: 2272-2277

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390292
  • [Journal Article] Roles of programmed death-1(PD-1)/PD-1 ligands pathway in the development of murine acute myocarditis caused by coxsackievirus B32007

    • Author(s)
      Seko, Y., H., Yagita, K., Okumura, M., Azuma, R., Nagai
    • Journal Title

      Cardiovascular research 75

      Pages: 158-167

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390292
  • [Journal Article] Involvement of TNF-like weak inducer of apoptosis in the pathogenesis of collagen-induced arthritis2006

    • Author(s)
      Kamata, K., S., Kamijo, A., Nakajima, A., Koyanagi, H., Kurosawa, H., Yagita, K., Okumura
    • Journal Title

      J lmmunol 177

      Pages: 6433-6439

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390292
  • [Journal Article] 2006. Ameliorating effect of saporin-conjugated anti-CD llb monoclonal antibody in a murine T-cell-mediated chronic colitis2006

    • Author(s)
      Kanai, T., K., Uraushihara, T., Totsuka, Y., Nemoto, R., Fujii, T., Kawamura, S., Makita, D., Sawada, H., Yagita, K., Okumura, M., Watanabe
    • Journal Title

      Journal of gastroenterology and hepatology 21

      Pages: 1136-1142

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390292
  • [Journal Article] IL-21 enhances tumor-specific CTL induction by anti-DR5 antibody therapy.2006

    • Author(s)
      Smyth MJ, Hayakawa Y, Cretney E, Zerafa N, Sivakumar P, Yagita H, Takeda K
    • Journal Title

      J Immunol 176

      Pages: 6347-6355

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016071
  • [Journal Article] Eradication of established tumors in mice by a combination antibody-based therapy.2006

    • Author(s)
      Uno T, Takeda K, Kojima Y, Yoshizawa H, Akiba H, Mittler RS, Gejyo F, Okumura K, Yagita H, Smyth MJ
    • Journal Title

      Nature Med 12

      Pages: 693-698

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016071
  • [Journal Article] Preferential involvement of Tim-3 in the regulation of hepatic CD8+ T cells in murine acute graft-versus-host disease2006

    • Author(s)
      Oikawa, T., Y., Kamimura, H., Akiba, H., Yagita, K., Okumura, H., Takahashi, M., Zeniya, H., Tajiri, M., Azuma
    • Journal Title

      J lmmuno 1177

      Pages: 4281-4287

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390292
  • [Journal Article] 2006. B7-Hi-induced apoptosis as a mechanism of immune privilege of corneal allografts2006

    • Author(s)
      Hori, J., M., Wang, M., Miyashita, K., Tanemoto, H., Takahashi, T., Takemori, K., Okumura, H., Yagita, M., Azuma
    • Journal Title

      J lmmunol 177

      Pages: 5928-5935

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390292
  • [Journal Article] 2006. Eradication of established tumors in mice by a combination antibody-based therapy2006

    • Author(s)
      Uno, T., K., Takeda, Y., Kojima, H., Yoshizawa, H., Akiba, R. S., Mittler, F., Gejyo, K., Okumura, H., Yagita, M. J., Smyth
    • Journal Title

      Nature medicine 12

      Pages: 693-698

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390292
  • [Journal Article] Amelioration of bone loss in collagen-induced arthritis by neutralizing anti-RANKL monoclonal antibody2006

    • Author(s)
      Kamijo, S., A., Nakajima, K., Ikeda, K., Aoki, K., Ohya, H., Akiba, H., Yagita, K., Okumura
    • Journal Title

      Biochemical and biophysical research communications 347

      Pages: 124-132

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390292
  • [Journal Article] B7-H1-induced apoptosis as a mechanism of immune privilege of corneal allografts.2006

    • Author(s)
      Hori J, Wang M, Miyashita M, Tanemoto K, Takahashi H, Takemori T, Okumura K, Yagita H, Azuma M
    • Journal Title

      J Immunol 177

      Pages: 5928-5935

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016071
  • [Journal Article] Development of a whole cell vaccine for acute myeloid leukaemia2006

    • Author(s)
      Cheuk, A., T., L., Chan, B., Czepulkowski, S. A., Berger, H., Yagita, K., Okumura, F., Farzaneh, G. J., Mufti, B. A., Guinn
    • Journal Title

      Cancer Immunol Immunother 55

      Pages: 68-75

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390292
  • [Journal Article] Programed death (PD) ligand-1/PD-1 interaction is required for CD8+ T cell tolerance to tissue antigens.2006

    • Author(s)
      Martin-Orozco N, Wang Y, Yagita H, Dong C
    • Journal Title

      J Immunol 177

      Pages: 8291-8295

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016071
  • [Journal Article] A novel dendritic cell subset involved in tumor immunosurveillance.2006

    • Author(s)
      Taieb J, Chaput N, Menard C, Apetoh L, Ullrich E, Bonmort M, Pequignot M, Casares N, Terme M, Flament C, Opolon P, Lecluse Y, Metivier G, Tomasello E, Vivier E, Ghiringhelli F, Martin F, Klatzmann D, Poynard T, Tursz T, Raposo G, Yagita H, Ryffel B, Kroemer G, Zitvogel L
    • Journal Title

      Nature Med 12

      Pages: 214-219

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016071
  • [Journal Article] Resistance of infant leukemia with MLL rearrangement to tumor necrosis factor-related apoptosis-inducing ligand : a possible mechanism for poor sensitivity to antitumor immunity2006

    • Author(s)
      Inukai, T., X., Zhang, M., Goto, K., Hirose, K., Uno, K., Akahane, A., Nemoto, K., Goi, H., Sato, K., Takahashi, H., Honna, K., Kagami, K., Nakamoto, H., Yagita, K., Okumura, T., Koyama-Okazaki, S., Nakazawa, K., Sugita
    • Journal Title

      Leukemia 20

      Pages: 2119-2129

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390292
  • [Journal Article] An antiapoptotic protein, c-FLIPL, directly binds to MKK7 and inhibits the JNK pathway2006

    • Author(s)
      Nakajima, A., S., Komazawa-Sakon, M., Takekawa, T., Sasazuki, W. C., Yeh, H., Yagita, K., Okumura, H., Nakano
    • Journal Title

      The EMBO journal 25

      Pages: 5549-5559

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390292
  • [Journal Article] TWEAK mediates anti-tumor effect of tumor-infiltrating macrophage.2005

    • Author(s)
      Kaduka Y, Takeda K, Nakayama M, Kinoshita K, Yagita H, Okumura K
    • Journal Title

      Biochem Biophys Res Commun 331

      Pages: 384-390

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016071
  • [Journal Article] Beta2-microglobulin required for cell surface expression of blastocyst MHC.2005

    • Author(s)
      Tanaka, T., T Ebata, A.Tajima, K.Kinoshita, K.Okumura, H.Yagita
    • Journal Title

      Biochem Biophys Res Commun 332

      Pages: 311-317

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390120
  • [Journal Article] IFN-gamma-mediated negative feedback regulation of NKT-cell function by CD94/NKG2.2005

    • Author(s)
      Ota, T., K.Takeda, H.Akiba, Y.Hayakawa, K.Ogasawara, Y.Ikarashi, S.Miyake, H.Wakasugi, T.Yamamura, M.Kronenberg, D.H.Raulet, K.Kinoshita, H.Yagita, M.J.Smyth, K.Okumura
    • Journal Title

      Blood 106

      Pages: 184-192

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390120
  • [Journal Article] Blockade of B7-H1 on macrophages suppresses CD4+ T cell proliferation by augmenting IFN-gamma-induced nitric oxide production.2005

    • Author(s)
      Yamazaki, T., H.Akiba, A.Koyanagi, M.Azuma, H.Yagita, K.Okumura
    • Journal Title

      J Immunol 175

      Pages: 1586-1592

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390120
  • [Journal Article] Critical contribution of CD8O and CD86 to induction of anterior chamber-associated immune deviation.2005

    • Author(s)
      Tsukahara, R., M.Takeuchi, H.Akiba, T.Kezuka, K.Takeda, Y.Usui, M.Usui, H.Yagita, K.Okumura
    • Journal Title

      Int Immunol 17

      Pages: 523-530

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390120
  • [Journal Article] Clinical significance of programmed death-1 ligand-1 and programmed death-1 ligand-2 expression in human esophageal cancer.2005

    • Author(s)
      Ohigashi Y, Sho M, Yamada Y, Tsurui Y, Hamada K, Ikeda N, Mizuno T, Yoriki R, Kashizuka H, Yane K, Tsushima F, Otsuki N, Yagita H, Azuma M, Nakajima Y
    • Journal Title

      Clin Cancer Res 11

      Pages: 2947-2953

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016071
  • [Journal Article] IFN-□-mediated negative feedback regulation of NKT cell function by CD94/NKG2.2005

    • Author(s)
      Ota T, Takeda K, Akiba H, Hayakawa Y, Ogasawara K, Ikarashi Y, Miyake S, Wakasugi H, Yamamura T, Kronenberg M, Raulet DH, Kinoshita K, Yagita H, Smyth MJ, Okumura K
    • Journal Title

      Blood 106

      Pages: 184-192

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016071
  • [Journal Article] 2005.TWEAK mediates anti-tumor effect of tumor-infiltrating macrophage.2005

    • Author(s)
      Kaduka, Y., K.Takeda, M.Nakayama, K.Kinoshita, H.Yagita, K.Okumura
    • Journal Title

      Biochem Biophys Res Commun 331

      Pages: 384-390

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390120
  • [Journal Article] Amelioration of acute graft-versus-host disease by NKG2A engagement on donor T cells.2005

    • Author(s)
      Kawamura, H., H.Yagita, T.Nisizawa, N.Izumi, C.Miyaji, R.E.Vance, D.H.Raulet, K.Okumura, T.Abo
    • Journal Title

      Eur J Immunol 35

      Pages: 2358-2366

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390120
  • [Journal Article] ICOS costimulates invariant NKT cell activation.2005

    • Author(s)
      Kaneda, H., K.Takeda, T.Ota, Y.Kaduka, H.Akiba, Y.Ikarashi, H.Wakasugi, M.Kronenberg, K.Kinoshita, H.Yagita, K.Okumura
    • Journal Title

      Biochem Biophys Res Commun 327

      Pages: 201-207

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390120
  • [Journal Article] Sequential activation of NKT cells and NK cells provides effective innate immunotherapy of cancer.2005

    • Author(s)
      Smyth MJ, Wallace ME, Nutt SL, Yagita H, Godfrey DI, Hayakawa Y
    • Journal Title

      J Exp Med 201

      Pages: 1973-1985

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016071
  • [Journal Article] TRAIL identifies immature natural killer cells in newborn mice and adult mouse liver.2005

    • Author(s)
      Takeda, K., E.Cretney, Y.Hayakawa, T.Ota, H.Akiba, K.Ogasawara, H.Yagita, K.Kinoshita, K.Okumura, M.J.Smyth
    • Journal Title

      Blood 105

      Pages: 2082-2089

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390120
  • [Journal Article] Tumor necrosis factor alpha (TNFalpha) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNFalpha.2005

    • Author(s)
      Xue, X., J.H.Piao, A.Nakajima, S.Sakon-Komazawa, Y.Kojima, K.Mori, H.Yagita, K.Okumura, H.Harding, H.Nakano
    • Journal Title

      J Biol Chem 280

      Pages: 33917-33925

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390120
  • [Journal Article] ICOS costimulates invariant NKT cell activation.2005

    • Author(s)
      Kaneda H, Takeda K, Ota T, Kaduka Y, Akiba H, Ikarashi Y, Wakasugi H, Kronenberg M, Kinoshita K, Yagita H, Okumura K
    • Journal Title

      Biochem Biophys Res Commun 327

      Pages: 201-207

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016071
  • [Journal Article] Renal allograft rejection is prevented by adoptive transfer of anergic T cells in nonhuman primates.2005

    • Author(s)
      Bashuda, H., M.Kimikawa, K.Seino, Y.Kato, F.Ono, A.Shimizu, H.Yagita, S.Teraoka, K.Okumura
    • Journal Title

      J Clin Invest 115

      Pages: 1896-1902

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390120
  • [Journal Article] Immune responses against a single CD8+-T-cell epitope induced by virus vector vaccination can successfully control Trypanosoma cruzi infection.2005

    • Author(s)
      Miyahira, Y., Y.Takashima, S.Kobayashi, Y.Matsumoto, T.Takeuchi, M.Ohyanagi-Hara, A.Yoshida, A.Ohwada, H.Akiba, H.Yagita, K.Okumura, H.Ogawa
    • Journal Title

      Infect Immun 73

      Pages: 7356-7365

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390120
  • [Journal Article] 2005.Regulation of murine chronic colitis by CD4+CD25-programmed death-1+ T cells.2005

    • Author(s)
      Totsuka, T., T.Kanai, S.Makita, R.Fujii, Y.Nemoto, S.Oshima, R.Okamoto, A.Koyanagi, H.Akiba, K.Okumura, H.Yagita, M.Watanabe
    • Journal Title

      Eur J Immunol 35

      Pages: 1773-1785

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390120
  • [Journal Article] Induction of CD70 on dendritic cells through CD40 or TLR stimulation contributes to the development of CD8+ T cell responses in the absence of CD4+ T cells.2005

    • Author(s)
      Bullock TNJ, Yagita H
    • Journal Title

      J Immunol 174

      Pages: 710-717

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016071
  • [Journal Article] The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo.2005

    • Author(s)
      Akiba, H., K.Takeda, Y.Kojima, Y.Usui, N.Harada, T.Yamazaki, J.Ma, K.Tezuka, H.Yagita, K.Okumura
    • Journal Title

      J Immunol 175

      Pages: 2340-2348

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390120
  • [Journal Article] Induction of RANTES by TWEAK/Fn14 interaction in human keratinocytes.2004

    • Author(s)
      Jin, L., A.Nakao, M.Nakayama, N.Yamaguchi, Y.Kojima, N.Nakano, R.Tsuboi, K.Okumura, H.Yagita, H.Ogawa
    • Journal Title

      J Invest Dermatol 122

      Pages: 1175-1179

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390120
  • [Journal Article] TRAIL and its receptors as targets for cancer therapy.2004

    • Author(s)
      Yagita, H. et al.
    • Journal Title

      Cancer Sci 95

      Pages: 777-783

    • NAID

      10014170265

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390120
  • [Journal Article] TRAIL and its receptors as targets for cancer therapy.2004

    • Author(s)
      Yagita, H.
    • Journal Title

      Cancer Sci. 95

      Pages: 777-783

    • NAID

      10014170265

    • Data Source
      KAKENHI-PROJECT-13214096
  • [Journal Article] Genome wide analysis of TNF-inducible genes reveals that antioxidant enzymes are induced by TNF and responsible for elimination of ROS.2004

    • Author(s)
      Sasazuki, T., T.Okazaki, K.Tada, S.Sakon-Komazawa, M.Katano, M.Tanaka, H.Yagita, K.Okumura, N.Tominaga, Y.Hayashizaki, Y.Okazaki, H.Nakano
    • Journal Title

      Mol Immunol 41

      Pages: 547-551

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390120
  • [Journal Article] TRAIL and its receptors as targets for cancer therapy.2004

    • Author(s)
      Yagita, H., K.Takeda, Y.Hayakawa, M.J.Smyth, K.Okumura
    • Journal Title

      Cancer Sci 95

      Pages: 777-783

    • NAID

      10014170265

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390120
  • [Journal Article] Induction of tumor-specific T cell immunity by anti-DR5 antibody therapy.2004

    • Author(s)
      Takeda, K., N.Yamaguchi, H.Akiba, Y.Kojima, Y.Hayakawa, J.E.Tanner, T.J.Sayers, N.Seki, K.Okumura, H.Yagita, M.J.Smyth
    • Journal Title

      J Exp Med 199

      Pages: 437-448

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390120
  • [Journal Article] TWEAK/Fn14 interaction stimulates human bronchial epithelial cells to produce IL-8 and GM-CSF.2004

    • Author(s)
      Xu, H., A.Okamoto, J.Ichikawa, T.Ando, K.Tasaka, K.Masuyama, H.Ogawa, H.Yagita, K.Okumura, A.Nakao
    • Journal Title

      Biochem Biophys Res Commun 318

      Pages: 422-427

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390120
  • [Journal Article] Sensitization of human glioblastomas to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) by NF-kappaB inhibitors.2004

    • Author(s)
      Kasuga, C., T.Ebata, N.Kayagaki, H.Yagita, M.Hishii, H.Arai, K.Sato, K.Okumura
    • Journal Title

      Cancer Sci 95

      Pages: 840-844

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390120
  • [Journal Article] Ameliorating effect of anti-ICOS monoclonal antibody in a murine model of chronic colitis.2003

    • Author(s)
      Totsuka T, Kanai T^#, Iiyama R, Uraushihara K, Yamazaki M, Okamoto R, Hibi T, Tezuka K, Azuma M, Akiba H, Yagita H, Okumura K, Watanabe M.
    • Journal Title

      Gastroenterology 124

      Pages: 410-421

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590627
  • [Journal Article] Preventive effects of chronic colitis in CD4^+CD45RB^+ T cell-transferred SCID mice by anti-FasL mAb administration.2003

    • Author(s)
      Dan N, Kanai T, Totsuka T, Iiyama R, Yamazaki M, Sawada T, Miyata T, Yagita H, Okumura K, Watanabe M.
    • Journal Title

      Am J Physiol GI & Liver 285

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590627
  • [Journal Article] The role of inducible co-stimulator (ICOS)/B7 related protein-1 (B7RP-1) interaction in the functional development of Peyer's patches.2003

    • Author(s)
      Iiyama R, Kanai T^#, Uraushihara K, Totsuka T, Nakamura T, Miyata T, Yagita H, Kushi A, Suzuki K, Tezuka K, Watanabe M.
    • Journal Title

      Immunol Letters 88

      Pages: 63-70

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590627
  • [Journal Article] Blockade of B7-H1 suppresses the development of chronic intestinal inflammation.2003

    • Author(s)
      Kanai T, Totsuka T, Uraushihara K, Makita S, Nakamura T, Koganei K, Fukushima T, Akiba H, Yagita H, Okumura K, Machida U, Iwai H, Azuma M, Chen L, Watanabe M.
    • Journal Title

      J Immunol 171

      Pages: 4156-4163

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590627
  • [Journal Article] Preventive and therapeutic effects of chronic colitis in CD4^+CD45RB^+ T cell-transferred SCID mice by anti-OX40L mAb administration.2003

    • Author(s)
      Totsuka T, Kanai T^#, Uraushihara K, Iiyama R, Akiba H, Yagita H, Okumura K, Watanabe M.
    • Journal Title

      Am J Physiol GI & Liver 284

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590627
  • [Journal Article] Regulation of murine chronic colitis by CD4^+CD25^-Programed Death-1^+ T cells.

    • Author(s)
      Totsuka T, Kanai T, Makita S, Fujii R, Nemoto Y, Oshima S, Okamoto R, Koyanagi A, Akiba H, Okumura K, Yagita H, Watanabe M.
    • Journal Title

      Eur J Immunol (in the press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590627
  • [Journal Article] 2006. The role of the ICOS/B7RP-1 T cell costimulatory pathway in murine experimental autoimmune uveoretinitis

    • Author(s)
      Usui, Y., H., Akiba, M., Takeuchi, T., Kezuka, A., Takeuchi, T., Hattori, Y., Okunuki, T., Yamazaki, H., Yagita, M., Usui, K., Okumura
    • Journal Title

      European journal of immunology 36

      Pages: 3071-3081

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390292
  • [Journal Article] Ameliorating effect of saporin-conjugated anti-CD11b monoclonal antibody in a murine T-cell-mediated chronic colitis.

    • Author(s)
      Kanai T^#, Uraushihara K, Totsuka T, Nemoto Y, Fujii R, kawamura T, Makita S, Yagita H, Okumura K, Watanabe M.
    • Journal Title

      J Gastrornt Hepatol (in the press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590627
  • [Presentation] Role of B7-H3/TLT-2 pathway in immune privilege of corneal allografts2017

    • Author(s)
      Taniguchi, H Hase, H Akiba, H Yagita, M Azuma
    • Organizer
      ARVO 2017 (The Association for Research in Vision and Ophthalmology)
    • Place of Presentation
      Baltimore, USA
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26462700
  • [Presentation] Augmented anti-cancer therapeutic effect using antibodies to multiple target molecules with immune checkpoint blockade.2016

    • Author(s)
      Terashima K, Tanaka M, Imaida T, Ueda S, Yagita H, Masuko T
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-26290059
  • [Presentation] Expression of ICOS and Foxp3 on T cells infiltrating in corneal allografts2016

    • Author(s)
      H Taniguchi, T Kunishige, H Akiba, H Yagita, R Abe, J Hori
    • Organizer
      ARVO 2016 (The Association for Research in Vision and Ophthalmology)
    • Place of Presentation
      Seattle, WA, USA
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26462700
  • [Presentation] Molecular mechanisms of immune privilege of the cornea - as a potential of Immune Checkpoint therapy2016

    • Author(s)
      J Hori, H Taniguchi, M Azuma, R Abe, H Yagita
    • Organizer
      Tokyo Ocular immunology meeting
    • Place of Presentation
      東京
    • Year and Date
      2016-02-26
    • Invited
    • Data Source
      KAKENHI-PROJECT-26462700
  • [Presentation] Non-apoptotic, non-necrotic novel cell death (anapocosis) of lymphoma cells induced by therapeutic mAbs.2016

    • Author(s)
      Matsuoka S, Ishii Y, Yagita H
    • Organizer
      第45回日本免疫学会学術集会
    • Place of Presentation
      沖縄コンベンションセンター
    • Year and Date
      2016-12-05
    • Data Source
      KAKENHI-PROJECT-26290059
  • [Presentation] Antigen delivery to tumoral macrophages leads to eradication of tumor resistant to immune checkpoint inhibitors.2016

    • Author(s)
      Muraoka D, Seo N, Harada N, Fujii K, Komuro M, Imoto S, Yamaguchi R, Miyano S, Yagita H, Akiyoshi K, Shiku H
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-26290059
  • [Presentation] Anti-pan MHC mAb induce cell death for ex-vivo lymphoma cells by anapocosis.2016

    • Author(s)
      Matsuoka S, Ishii Y, Takamatsu H, Hasegawa H, Mizutani N, Yagita H, Hino O
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-26290059
  • [Presentation] Expression of ICOS and Foxp3 on T cells infiltrating in corneal allografts2016

    • Author(s)
      H Taniguchi, T Kunishige, H Akiba, H Yagita, R Abe, J Hori
    • Organizer
      ARVO
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2016-05-01
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26462700
  • [Presentation] A combination of anti-angiogenic and anti-lymphangiogenic therapies augments effects of an antitumor immunotherapy.2016

    • Author(s)
      Tsukita Y, Okazaki T, Yagita H, Ichinose M
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-26290059
  • [Presentation] Effect of regulation of immune checkpoint molecules on ADCC with NK cells.2015

    • Author(s)
      Tanaka M, Terashima K, Imaida T, Abe S, Ueda S, Yagi H, Yagita H, Masuko T
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-10-08
    • Data Source
      KAKENHI-PROJECT-26290059
  • [Presentation] The immunogenicity of antigen decides the tumoral inflammation and therapeutic efficacy of immune checkpoint blockades.2015

    • Author(s)
      Muraoka D, Seo N, Hayashi T, Harada N, Komura M, Yamaguchi R, Imoto S, Miyano S, Yagita H, Shiku H
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-10-08
    • Data Source
      KAKENHI-PROJECT-26290059
  • [Presentation] Cytolytic anti-pan HLA-class II mAb and anti-pan MHC class I mAb directly induces lymphoma cell death via large pore formation.2015

    • Author(s)
      Matsuoka S, Yagita H, Ishii Y
    • Organizer
      第44回日本免疫学会学術集会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2015-11-18
    • Data Source
      KAKENHI-PROJECT-26290059
  • [Presentation] VISTA and CTLA-4 combination blockade enhances multifunctionality of tumor infiltrating CD8+ T cells.2015

    • Author(s)
      Kondo Y, Ohno T, Bhingare AC, Yagita H, Harada K, Azuma M
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-10-08
    • Data Source
      KAKENHI-PROJECT-26290059
  • [Presentation] Combination immune checkpoint blockade with VISTA and CTLA-4 enhances anti-tumor responses.2015

    • Author(s)
      Kondo Y, Ohno T, Bhingare AC, Yagita H, Harada K, Azuma M
    • Organizer
      第44回日本免疫学会学術集会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2015-11-18
    • Data Source
      KAKENHI-PROJECT-26290059
  • [Presentation] Corneal Cell-Mediated Immune Regulation and Immune Privilege2015

    • Author(s)
      J Hori, H Taniguchi, M Azuma, R Abe, H Yagita
    • Organizer
      Harvard Medical School Cornea Center of Excellence international Workshop
    • Place of Presentation
      Boston, MA, USA
    • Year and Date
      2015-10-15
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26462700
  • [Presentation] 角膜移植後の免疫寛容における Tim-3 / Gal-9 経路の抑制的役割2012

    • Author(s)
      榛村真智子、堀 純子、王明聡、谷口ヒロ子、高橋浩、梯彰弘、 秋葉久弥、八木田秀雄
    • Organizer
      第 46 回日本眼炎症学会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23592619
  • [Presentation] アジュバントとしての免疫賦活化抗体2012

    • Author(s)
      八木田秀雄
    • Organizer
      日本がん免疫学会
    • Place of Presentation
      北海道大学学術交流会館
    • Invited
    • Data Source
      KAKENHI-PROJECT-22240089
  • [Presentation] 角膜移植後の免疫寛容におけるTim-3 / Gal-9経路の抑制的役割2012

    • Author(s)
      榛村真智子、堀純子、王明聡、谷口ヒロ子、高橋浩、梯彰弘、秋葉久弥、八木田秀雄
    • Organizer
      第46回日本眼炎症学会
    • Place of Presentation
      横浜
    • Year and Date
      2012-07-15
    • Data Source
      KAKENHI-PROJECT-23592619
  • [Presentation] 角膜移植後の眼局所におけるTLT-2の発現と機能2011

    • Author(s)
      谷口ヒロ子、堀純子、秋葉久弥、八木田秀雄、長谷英徳、東みゆき
    • Organizer
      第115回日本眼科学会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-12
    • Data Source
      KAKENHI-PROJECT-23592619
  • [Presentation] Correlation between proportion of splenic Foxp3+CD8+T regulatory cells and corneal allograft survival2011

    • Author(s)
      K. Wakayama, H. Taniguchi, H. Akiba, H. Yagita, M. Azuma, J. Hori
    • Organizer
      ARVO
    • Place of Presentation
      USA
    • Year and Date
      2011-05-01
    • Data Source
      KAKENHI-PROJECT-23592619
  • [Presentation] Correlation between proportion of splenic Foxp3+CD8+T regulatory cells and corneal allograft survival.2011

    • Author(s)
      K. Wakayama, H. Taniguchi, H. Akiba, H. Yagita, M. Azuma, J. Hori.
    • Organizer
      Association for Research in Vision and Ophthalmology(ARVO)
    • Place of Presentation
      フロリダ
    • Data Source
      KAKENHI-PROJECT-23592619
  • [Presentation] 角膜アログラフトの生着における脾臓内Foxp3+CD8+制御性T細胞の関与2011

    • Author(s)
      谷口ヒロ子、堀純子、秋葉久弥、八木田秀雄、東みゆき
    • Organizer
      第45回日本眼炎症学会
    • Place of Presentation
      京都
    • Year and Date
      2011-07-09
    • Data Source
      KAKENHI-PROJECT-23592619
  • [Presentation] 角膜移植の免疫特権におけるTim-3/Gal-9経路の役割2011

    • Author(s)
      榛村真智子、堀純子、王明聡、谷口ヒロ子、秋葉久弥、八木田秀雄
    • Organizer
      第16回Tokyo Ocular Immunology Meeting
    • Place of Presentation
      東京
    • Year and Date
      2011-09-30
    • Data Source
      KAKENHI-PROJECT-23592619
  • [Presentation] Expression of TLT-2 in corneal tissue and macrophages after corneal transplantation and association with immune privilege of corneal allografts2011

    • Author(s)
      H. Taniguchi, H. Sase, H. Akiba, H. Yagita, M. Azuma, J. Hori
    • Organizer
      ARVO
    • Place of Presentation
      USA
    • Year and Date
      2011-05-04
    • Data Source
      KAKENHI-PROJECT-23592619
  • [Presentation] 腫瘍免疫の基礎理論2010

    • Author(s)
      八木田秀雄
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2010-09-24
    • Data Source
      KAKENHI-PROJECT-22240089
  • [Presentation] 抗体を用いた抗腫瘍免疫の誘導と増強2008

    • Author(s)
      八木田秀雄
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-10-28
    • Data Source
      KAKENHI-PROJECT-17016071
  • [Presentation]2008

    • Author(s)
      Takeda K, Kojima Y, Yagita H, Smyth MJ, Okumura K
    • Organizer
      第38回日本免疫学会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2008-12-01
    • Data Source
      KAKENHI-PROJECT-19590257
  • [Presentation]2008

    • Author(s)
      Kojima Y, Takeda K, Yagita H, Smyth MJ, Okumura K
    • Organizer
      第38回日本免疫学会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2008-12-01
    • Data Source
      KAKENHI-PROJECT-19590257
  • [Presentation] Commensal bacteria regulate thymic Aire expression

    • Author(s)
      Nakajima A, Negishi N, Tsurui H, Nanno M, Yagita H, Okumura K, Miyake S, Habu S
    • Organizer
      第43回日本免疫学会学術集会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2014-12-10 – 2014-12-12
    • Data Source
      KAKENHI-PROJECT-26290059
  • [Presentation] Anti-tumor effects of mAb against a new immune-checkpoint molecule VISTA

    • Author(s)
      Kondo Y, Ohno T, Zhang C, Yagita H, Harada K, Azuma M
    • Organizer
      第73回日本癌学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PROJECT-26290059
  • [Presentation] Therapeutic anti-pan HLA class II mAb induces the death of leukemia/lymphoma cells via large pore formation

    • Author(s)
      Matsuoka S, Mizutani N, Yagita H, Hino O
    • Organizer
      第73回日本癌学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PROJECT-26290059
  • [Presentation] TNFR2 signaling in the epithelia may be involved in the development of colitis-associated tumor

    • Author(s)
      Watabe T, Nagaishi T, Suzuki M, Yamazaki M, Onizawa M, Jose N, Tokai A, Hosoya A, Totsuka M, Yagita H, Watanabe M
    • Organizer
      第43回日本免疫学会学術集会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2014-12-10 – 2014-12-12
    • Data Source
      KAKENHI-PROJECT-26290059
  • [Presentation] Anti-pan MHC class I and class II mAbs directly induce lymphoma cell death via large pore formation

    • Author(s)
      Matsuoka S, Yagita H, Ishii Y
    • Organizer
      第43回日本免疫学会学術集会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2014-12-10 – 2014-12-12
    • Data Source
      KAKENHI-PROJECT-26290059
  • [Presentation] Anti-tumor effects of mAb against a new immune-checkpoint molecule VISTA/PD-1H

    • Author(s)
      Kondo Y, Ohno T, Zhang C, Yagita H, Harada K, Azuma M
    • Organizer
      第43回日本免疫学会学術集会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2014-12-10 – 2014-12-12
    • Data Source
      KAKENHI-PROJECT-26290059
  • [Presentation] The suppression of naive T cells requires cell-to-cell contact by TSST-1-induced anergic T cellls

    • Author(s)
      Negishi N, Sato T, Kametani Y, Hori S, Yagita H, Okumura K, Habu S
    • Organizer
      第43回日本免疫学会学術集会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2014-12-10 – 2014-12-12
    • Data Source
      KAKENHI-PROJECT-26290059
  • [Presentation] Combination immunotherapy with 4-1BB mAb and PD-1 mAb enhances antitumor efficacy in mouse subcutaneous model

    • Author(s)
      Shindo Y, Yoshimura K, Kuramasu A, Ito H, Oga A, Maeda N, Yoshino S, Hazama S, Tamada K, Yagita H, Oka M
    • Organizer
      第73回日本癌学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PROJECT-26290059
  • 1.  OKUMURA Ko (50009700)
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  • 2.  AZUMA Miyuki (90255654)
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  • 4.  NAKANO Hiroyasu (70276476)
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  • 5.  HIRANO Takao (10165186)
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  • 99.  徳永 万喜洋
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  • 100.  大場 雄介
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  • 101.  瀬谷 司
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  • 104.  中尾 篤人
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  • 105.  増谷 弘
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  • 106.  荒瀬 尚
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  • 107.  JIN HUI
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  • 108.  加藤 昌志
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  • 110.  砂村 眞琴
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  • 111.  症 雅之
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  • 114.  早川 芳弘
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 115.  岡田 太
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 116.  善本 隆之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 117.  済木 育夫
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 118.  安倍 能之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 119.  大野 建州
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 120.  千葉 滋
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 121.  加藤 貴康
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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