YAGITA Hideo 八木田秀雄

Researcher Number	30182306
Other IDs
Affiliation (Current)	2020: 順天堂大学, 医学部, 先任准教授
Affiliation (based on the past Project Information) *help	2017: 順天堂大学, 医学部免疫学講座, 準教授 2007 – 2016: Juntendo University, Immunology, Associate professor 2012: 順天堂大学, 医学部, 先任准教授 2008 – 2009: 順天堂大学, 医学部, 先任准教授 1988 – 2006: Associate Professor, Juntendo Univ., Sch. of Medicine, 医学部, 助教授 … More
Review Section/Research Field	Principal Investigator Immunology / Biological Sciences / Tumor immunology / Tumor therapeutics Except Principal Investigator Immunology / Biological Sciences / Hematology / 内科学一般 / Ophthalmology / Cerebral neurosurgery … More
Keywords	Principal Investigator CD27 / DR5 / TWEAK / TRAIL / CD2 / キラーT細胞 / CD70 / LFA-1 / ICAM-1 / OX40 … More Except Principal Investigator Fas / FasL / LFA / VLA / CD2 / CD80 / アポトーシス / CD86 / CD28 / GVHD / NK細胞 / パーフォリン / CD48 / TWEAK / TNF-α / MPI / HVG / GVH / metalloproteinase inhibitor / GVL / CD8 / パ-フォリン / LAK細胞 / 接着分子 / B細胞 / T細胞 / モノクロ-ナル抗体 / 抗体療法 / バイスペシフィック抗体 / がん遺伝子産物 / 画像診断 / イディオタイプ抗体 / NK / T細胞活性化 / キラー細胞 / VLA-4 / TRAIL / TNF / IL-7 / 慢性大腸炎 / 再生医療 / 炎症性腸疾患 / tolerance / Th1 / Th2 / HVGD / IL-4 / メタロプロテナーゼインヒビター / HIV / CD4 / キラ-細胞 / マクロファ-ジ / ストロ-マ細胞 / トランスジェニックマウス / ガングリオシド抗原 / LAK / 胸腺 / T細胞受容体 / ECM / モノクローナル抗体 / キラーT細胞 / インテグリン / フィブロネクチン / CTLA-4 / IL-7レセプター / 腸管免疫 / 粘膜リンパ球 / 腸管上皮細胞 / Notchシグナル / 免疫特権 / 副刺激シグナル / 移植免疫応答 / ICOS/B7RP-1(ICOSL) / ICOS/B7RP-1 / mAb / lymphocyte / トランスフェクタント / T cell / monoclonal antibody / VLA-5 / TNF-R / 全身性エリテマトーデス / CCR5 / CCR4 / TNF-alpha / 腸内細菌 / 自然免疫 / IgA / 自己免疫疾患 / Fn14 / 血管新生 / IL-2R / 標的細胞破壊 / キラ-因子 / バクスペンフィック抗体 / エレ-ヌ / cーKit / 細胞接着分子 / Perforin / r / 8 T cell / ヒトT細胞抗原 / 10D1 / T細胞分化 / ILー2 / ILー2R / キラ-T細胞 / 共焦点レザ-顕微鏡 / 骨髄 / ILー7 / SLF / ガングリオシ-ド抗原 / Killer T / 腫瘍細胞破壊機構 / 抗原ペプチド / マクロファージレクチン / 共集点レーザー顕微鏡 / B細胞初期分化 / ストローマ細胞 / 造血幹細胞 / CD34 / I型糖尿病 / 糖鎖転移酵素遺伝子 / NKレセプター / リガンド分子 / レクチン / 細胞障害機序 / B7 / B70 / 造血 / 赤芽球 / 赤芽球コロニー / 胎仔肝 / レトロウイルスベクター / 細胞ターゲッティング / 双特異性抗体 / 白血病細胞 / CALLA抗体 / 単クローン抗体 / 悪性グリオーマ / 腫瘍浸潤リンパ球 / T細胞抗原レセプター / 遺伝子治療 / 共刺激分子 / 免疫制御 / 免疫応答 / 86 / T細胞死 / CD4分子 / gp120 / AIDS / マトリックスメタロプロテアーゼ / SIV感染カニクイサル / 細胞障害性リンパ球 / Fasリガンド / 生体防御 / 抗腫瘍効果 / CTL / IFN / 細胞傷害活性 / 血清ホモシスチン / 葉酸 / ビタミンB12 / ビタミンB6 / 無症候性脳梗塞 / 寿命 / メチレンテトラハイドロ葉酸還元酵素 / ビタミンB_6 / ビタミンB_<12> / 骨髄細胞 / 転写因子 / transdifferentiation / 杯細胞分化 / Interferon Regulatory Factor (IRF) / Wntシグナル / 抗腫瘍免疫 / DR5 / 腫瘍細胞 / 局在 / がん抗体療法 / 胆管閉塞 / Importin β1 / PSC / TRAILレセプター / Galectin-9/Tim-3 / GITR/GITRL / ICOS/ICOSL / リンパ腫 / リンパ球の分化 / ホーミング / 分化抗原 / クローナリティー / T細胞レセプター遺伝子 / 免疫グロブリン遺伝子 / lympocyte / TcR / トレランス / 自己免疫 / 移植 / モノクロナール抗体 / 移植拒絶 / Thy-1 / ヘルパーT細胞 / 免疫寛容 / 拒絶反応 / allograft rejection / auto immune disease / マスト細胞 / FcεRI / IgE / 活性化 / フィブロネクチン(FN) / ビトロネクチン(VN) / ラミニン(LM) / コラーゲン(CL) / VLA-3,4,5 / RGDペプチド / 抗VLA-4抗体 / fibronectin / fibronectin receptor / rat mast cells / CD40 / ジーンターゲッティン / CD80,CD86 / CD27 / CD95L / 寛容 / アナジー / エイズ / anergy / HLA-classII / 児 / 抗核抗体 / HLA-class II / 妊娠 / SLE / HLA-classll / children / antinuclear antibodies / B cell / ルーブス腎炎 / ケモカインレセプター / シェーグレン症候群 / ループス腎炎 / 補体(CH50、C3) / Systemic Lupus Erythemotosus / Lupus Nephritis / Chemokine Receptor / sjogren's syndrome / 遺伝子 / 癌抗原 / ペプチド / 免疫 / ワクチン / 探索的臨床研究 / テーラーメイド型医療 / 拒絶抗原 / がん / 抗原 / 免疫療法 / Gene / Tumor antigen / Peptide / Immunity / Cytotoxic T lymphocytes / Vaccine / Translational reearch / Personalized medicine / 腫瘍壊死因子 / costimulatory molecule / 乳酸菌 / マウス実験腸炎モデル / OX40 / inflammatory bowel disease / therapy / mucosal immunity / oral tolerance / commensal bacteria / chronic colitis / costimulation / マウスモデル / 抗原特異性 / クローン病 / 潰瘍性大腸炎 / プロバイオテクス / 細胞移入 / 調節性T細胞 / 調節製T細胞 / 腸管粘膜免疫 / 単クローン / 慢性大腸炎モデル / inflammatory bowel diseases / murine model / Antigen-specific / Crohn's disease / Ulcerative colitis / Probiotics / Cell transfer / Transgenic mice / 腫瘍 / サイトカイン / 腫瘍拒絶 / IκBα / IL-8 / GM-CSF / RANTES / 炎症 / tumor / apoptosis / cytokine / angiogenesis / tumor rejection / 関節炎モデル / 実験的自己免疫性ぶどう膜網膜炎 / OVA誘発性喘息 / 実験的自己免疫性脳脊髄炎 / 補助シグナル分子 / CD28-B7ファミリー / TNF-TNFRファミリー / コラーゲン誘発性関節炎 / B7RP-1 / autoimmune diseases / collagen-induced arthritis / experimental autoimmune uveoretinitis / murine model of asthma / experimental autoimmune encephalomyelitis / costimulatory molecules / CD28-B7 family / TNF-TNFR family / TS / トランスフェクション / CD8遺伝子 / CD2遺伝子 / リンパ球機能分子 / FACS / DNAクローニング / サプレッサーT細胞 / T細胞レセプター / T細胞機能分子 / Ts / Monoclonal Antibody / 腫瘍微小環境 / リンパ管新生 / 腫瘍免疫 / 抗リンパ管新生療法 / 抗血管新生療法 / 血管 / リンパ管 / VISTAシグナル / 癌免疫療法 / 体外活性化T細胞療法 / 活性化T細胞療法 / 癌ワクチン療法 / 樹状細胞ワクチン療法 / Notch ligand Delta4 / 樹状細胞ワクチン Less

Cancer vaccine with Th1 inducing DC through Notch ligand Dll4
- Principal Investigator
  
  Mochizuki Kazuhiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Fukushima Medical University
Establishment of immuno-stimulatory antibody therapy against cancerPrincipal Investigator
- Principal Investigator
  
  YAGITA Hideo
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Juntendo University
Sunitinib improves tumor microenvironment and augments the T cell infiltration and the effect of immunotherapy by DR-5
- Principal Investigator
  
  Okazaki Tatsuma
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Tohoku University
Immune regulation for tissue transplantation and regeneration in the eye
- Principal Investigator
  
  Hori Junko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Nippon Medical School
Molecular mechanisms of immunosuppressive intraocular microenvironment in corneal transplantation
- Principal Investigator
  
  HORI Junko
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Nippon Medical School
Development of immuno-stimulatory antibody therapy against cancerPrincipal Investigator
- Principal Investigator
  
  YAGITA Hideo
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Tumor immunology
- Research Institution
  Juntendo University
Contribution of intracellular TRAIL receptor to regulation of apoptosis induced by TRAIL
- Principal Investigator
  
  KOJIMA Yuko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Juntendo University
Functional analysis of costimulatory molecules for autoimmune diseases
- Principal Investigator
  
  OKUMURA Ko
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Juntendo University
Molecular mechanism of cancer immunosurveillance and its application to cancer therapyPrincipal Investigator
- Principal Investigator
  
  YAGITA Hideo
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Juntendo University
粘膜免疫の特殊性を応用した腸管免疫統御療法の開発
- Principal Investigator
  
  渡辺守
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
REGULATION OF TUMOR VESSEL FORMATION BY THE IMMUNE SYSTEM
- Principal Investigator
  
  OKUMURA Ko
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  JUNTENDO UNIVERSITY
粘膜免疫の特殊性を応用した腸管免疫統御療法の開発
- Principal Investigator
  
  渡辺守
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
Establishment of transgenic mice that recognize bacteria specific antigen and develop spontaneous colitis under specific pathogen free condition.
- Principal Investigator
  
  KANAI Takanori
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
消化管粘膜免疫の特殊性を応用した腸管免疫機構の統御療法
- Principal Investigator
  
  WATANABE Mamoru
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
Physiological and pathological functions of TNF/TNF receptor family molecules.Principal Investigator
- Principal Investigator
  
  YAGITA Hideo
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Juntendo University
Molecular mechanisms for tumor recognition and destruction by NK cells.Principal Investigator
- Principal Investigator
  
  YAGITA Hideo
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Juntendo University
Establishment of a novel therapy of Inflammatory bowel disease by inducible oral tolerance
- Principal Investigator
  
  KANAI Takanori
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
TNF/TNF受容体ファミリー分子の発現と機能の解析Principal Investigator
- Principal Investigator
  
  八木田秀雄
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Juntendo University
Study of tumor associated antigens recognized by human CD8^+ cytotoxic T lymphocytes
- Principal Investigator
  
  ITOH Kyogo
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kurume University School of Medicine
Differential effects of anti Fas ligand and MPI on GVHD pathologies
- Principal Investigator
  
  HIRANO Takao
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Juntendo University
Differential effects of anti Fas ligand and anti TNF-alpha antibodies on GVHD pathologies
- Principal Investigator
  
  HIRANO takao
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Juntendo University
細胞障害性リンパ球による標的細胞破壊機構の解明およびその制御
- Principal Investigator
  
  奥村康
- Project Period (FY)
  1999 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Juntendo University
ヒトの寿命とメチレンテトラハイドロ葉酸還元酵素遺伝子異常
- Principal Investigator
  
  佐々木英忠
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Tohoku University
A metalloproteinase inhibitor prevents acute graft-versus-host disease while preserving graft-versus-leukemia effect of allogeneic bone marrow transplantation
- Principal Investigator
  
  MIYAJIMA Hiroaki
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  JUNTENDO UNIVERSITY
Analysis of Thl/Th2 imbalance of systemic lupus erythematosus
- Principal Investigator
  
  YAMADA Masato
- Project Period (FY)
  1999 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  Juntendo University
HIV感染におけるT細胞アポトーシス誘導機序
- Principal Investigator
  
  小柳津直樹
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
細胞死(アポトーシス)誘導分子をターゲットとしたAIDS発症抑制
- Principal Investigator
  
  奥村康
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Juntendo University
A long duration follow up of childern born to patients With systematic lupus erythematosus (SLE)
- Principal Investigator
  
  HASHIMOTO Hiroshi
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内科学一般
- Research Institution
  Juntendo University
CD28シグナル制御による免疫応答調節とその分子機構の解折
- Principal Investigator
  
  東みゆき
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  National Research Institute for Child Health and Development
Analyses on artifical induction of antigen-specific immunological tolerancePrincipal Investigator
- Principal Investigator
  
  YAGITA Hideo
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Juntendo University School of Medicine
CD28シグナル制御による免疫応答調節とその分子機構解析
- Principal Investigator
  
  AZUMA Miyuki
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Juntendo University
Studies on the differention and activation mechanisms of T cell vi lymphocye functioning antigen (LFA).
- Principal Investigator
  
  OKUMURA Ko
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Immunology
- Research Institution
  Juntendo University School of Medicine
抗潰瘍エフェクター機序の解析Principal Investigator
- Principal Investigator
  
  八木田秀雄
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Juntendo University
悪性グリオーマ浸潤リンパ球に於けるT細胞抗原レセプターの分子生物学的解析
- Principal Investigator
  
  新田泰三
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Juntendo University
インテグリン分子のリンパ球・血液細胞の分化に果たす役割
- Principal Investigator
  
  武内ゆみ子
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
レトロウイルスベクター系を用いた腫瘍細胞ターゲッティング法の開発:癌・白血病の遺伝子治療にむけたレトロウイルスベクターへの悪性リンパ腫特定細胞親和性の賦与
- Principal Investigator
  
  谷憲三朗
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
Analysis of adhesion molecules on mast cells
- Principal Investigator
  
  HIRANO Takao, 奥村康
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Juntendo University
Analyzes on artifical induction of antigen-specific immunological tolerancePrincipal Investigator
- Principal Investigator
  
  YAGITA Hideo
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Juntendo University, School of Medicine
腫瘍細胞破壊のキラーメカニズム
- Principal Investigator
  
  橋本嘉幸
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tohoku University
リンパ系幹細胞とストローマ細胞間の相互作用に関する研究
- Principal Investigator
  
  西川伸一
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kumamoto University
モノクローナル抗体による腫瘍関連抗原の検出と治療への応用
- Principal Investigator
  
  高橋利忠
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Aichi Cancer Center Research Institute
研究課的ヒトキラー細胞に発現する新しいレクチン様分子の構造と腫瘍障害性における機能の解析
- Principal Investigator
  
  屋部登志雄
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Juntendo University
キラーT細胞による腫瘍細胞の認識と破壊機構の解明Principal Investigator
- Principal Investigator
  
  八木田秀雄, 奥村康
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Juntendo University
Sudies on the differention and activation mechanisms of T cell via lymphocye functioning antigen (LFA).
- Principal Investigator
  
  OKUMURA Ko
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Immunology
- Research Institution
  Juntendo University
腫瘍細胞破壊のキラ-メカニズム
- Principal Investigator
  
  橋本嘉幸
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tohoku University
リンパ系幹細胞とストロ-マ細胞間の相互作用に関する研究
- Principal Investigator
  
  西川伸一
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kumamoto University
モノクロ-ナル抗体による腫瘍関連抗原の検出と治療への応用
- Principal Investigator
  
  高橋利忠
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Aichi Cancer Center Research Institute
腫瘍細胞破壊のキラ-メカニズム
- Principal Investigator
  
  橋本嘉幸
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tohoku University
リンパ系幹細胞とストロ-マ細胞間の相互作用に関する研究
- Principal Investigator
  
  西川伸一
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kumamoto University
モノクロ-ナル抗体による腫瘍関連抗原の検出と治療への応用
- Principal Investigator
  
  高橋利忠
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Aichi Cancer Center Research Institute
キラ-T細胞による腫瘍細胞の認識と破壊機構の解明
- Principal Investigator
  
  奥村康
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Juntendo University
ヒトT細胞膜抗原10D1の胸線内T細胞分化・活性化における役割の解析
- Principal Investigator
  
  OBATA Tetsuji
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Juntendo University
キラ-T細胞による腫瘍細胞の認識と破壊機構の解明
- Principal Investigator
  
  奥村康
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Juntendo University
Molecular biological study on intercellular adhesion molecules involved in activation and differentiation of hematopoietic cells.Principal Investigator
- Principal Investigator
  
  YAGITA Hideo
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Juntendo University School of Medicine
キラー細胞による腫瘍細胞障害性とその誘導機序及びそれに対する抵抗性の分子的解析Principal Investigator
- Principal Investigator
  
  八木田秀雄
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Juntendo University
HIV感染によるCD4陽性T細胞減少機序の分子免疫学的解析
- Principal Investigator
  
  奥村康
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Juntendo University
Immuno-Melecular characterization of lymphocyte functioning antigen (LFA)
- Principal Investigator
  
  OKUMURA Ko
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Juntendo University School of Medicine
MHC非抱亜性キラー細胞による腫瘍の認識及び破壊機構の解明とその制癌への応用Principal Investigator
- Principal Investigator
  
  八木田秀雄
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Juntendo University
Importance of CD2-LFA-3 interaction in differentiation and function of T and NK cells.Principal Investigator
- Principal Investigator
  
  YAGITA Hideo
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Juntendo University School of Medicine
マウス及びヒトT細胞白血病の転移におけるT細胞クロノタイプ及び分化抗原の転換
- Principal Investigator
  
  奥村康
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Juntendo University
Immuno Molecular Analysis of Suppressor T cell receptor
- Principal Investigator
  
  OKUMURA Ko
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Juntendo University

[Book] 標準免疫学2013
- Author(s)
  八木田秀雄
- Total Pages
  459
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-22240089
[Book] 抗体を用いたがんに対する免疫応答の制御2009
- Author(s)
  八木田秀雄
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-17016071
[Journal Article] SCIB2, an antibody DNA vaccine encoding NY-ESO-1 epitopes, induces potent antitumor immunity which is further enhaned by checkpoit blockade.2016
- Author(s)
  Xue W, Metheringham RL, Brentville VA, Gunn B, Symonds P, Yagita H, Ramage JM, Durrant LG
- Journal Title
  
  Oncoimmunology
  
  Volume: 5(6)
- DOI
  10.1080/2162402x.2016.1169353
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290059
[Journal Article] Radiation-induced enhancement of antitumor T cell immunity by VEGF-targeted 4-1BB costimulation.2016
- Author(s)
  Schrand B, Verma B, Levay A, Patel S, Castro I, Benaduce AP, Brenneman R, Umland O, Yagita H, Gilboa E, Ishkanian AS
- Journal Title
  
  Cancer Res
  
  Volume: 77(6) Pages: 1310-1321
- DOI
  10.1158/0008-5472.can-16-2105
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290059
[Journal Article] Systemic DC Activation Modulates the Tumor Microenvironment and Shapes the Long-Lived Tumor-Specific Memory Mediated by CD8+ T Cells.2016
- Author(s)
  Shimizu K, Yamasaki S, Shinga J, Sato Y, Watanabe T, Ohara O, Kuzushima K, Yagita H, Komuro Y, Asakura M, Fujii S
- Journal Title
  
  Cancer Res.
  
  Volume: 76(13) Pages: 3756-3766
- DOI
  10.1158/0008-5472.can-15-3219
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26290059, KAKENHI-PROJECT-26430179, KAKENHI-PROJECT-15K09590
[Journal Article] Establishment of a therapeutic anti-pan HLA-class II monoclonal antibody that directly induces lymphoma cell death via large pore formation.2016
- Author(s)
  Matsuoka S, Ishii Y, Nakao A, Abe M, Ohtsuji N, Momose S, Jin H, Arase H, Sugimoto K, Nakauchi Y, Masutani H, Maeda M, Yagita H, Komatsu N, Hino O
- Journal Title
  
  PLoS One.
  
  Volume: 11
- DOI
  10.1371/journal.pone.0150496
- NAID
  120005838168
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04864, KAKENHI-PROJECT-25460386, KAKENHI-PROJECT-26670475, KAKENHI-PROJECT-15H02545, KAKENHI-PROJECT-15F15115, KAKENHI-PROJECT-26290059
[Journal Article] CD27 agonism plus PD-1 blockade recapitulates CD4+ T cell help in terapeutic anti-cancer vaccination.2016
- Author(s)
  Ahrends T, Babala N, Xiao Y, Yagita H, van Eenennaam H, Borst J
- Journal Title
  
  Cancer Res
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290059
[Journal Article] Agonistic CD40 mAb-driven IL-12 reverses resistance to anti-PD1 in a T cell-rich tumor.2016
- Author(s)
  Ngiow SF, Young A, Blake SJ, Hill GR, Yagita H, Teng MW, Korman AJ, Smyth MJ
- Journal Title
  
  Cancer Res
  
  Volume: 76(21) Pages: 6266-6277
- DOI
  10.1158/0008-5472.can-16-2141
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290059
[Journal Article] Combination anti-CTLA-4 and anti-RANKL in metastatic melanoma.2016
- Author(s)
  Smyth MJ, Yagita H, McArthur GA
- Journal Title
  
  J Clin Oncol
  
  Volume: 34(12)
- DOI
  10.1200/jco.2013.51.3572
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290059
[Journal Article] IL-17A-producing CD30+ Vδ1 T cells drive inflammation-induced cancer progression2016
- Author(s)
  Kimura Y, Nagai N, Tsunekawa N, Sato-Matsushita M, Yoshimoto T, Cua DJ, Iwakura Y, Yagita H, Okada F, Tahara H, Saiki I, Irimura T, Hayakawa Y.
- Journal Title
  
  Cancer Sci
  
  Volume: 107 Pages: 1106-1214
- DOI
  10.1111/cas.13005
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011, KAKENHI-PROJECT-15J11569, KAKENHI-PROJECT-25293011, KAKENHI-PROJECT-26290059, KAKENHI-PROJECT-26430158, KAKENHI-PROJECT-26460472, KAKENHI-PROJECT-15K07947, KAKENHI-PROJECT-15K08433, KAKENHI-PROJECT-15K08902, KAKENHI-PROJECT-26670023
[Journal Article] Protective Role of ICOS and ICOS Ligand in Corneal Transplantation and in Maintenance of Immune Privilege.2016
- Author(s)
  Kunishige T, Taniguchi H, Terada M, Akiba H, Yagita H, Abe R, Hori J
- Journal Title
  
  Invest Ophthalmol Vis Sci
  
  Volume: 57(15) Pages: 6815-6823
- DOI
  10.1167/iovs.16-20644
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26462700, KAKENHI-PROJECT-15K20290, KAKENHI-PROJECT-16K09924
[Journal Article] The Notch ligand DLL4 defines a capability of human dendritic cells in regulating Th1 and Th17 differentiation.2016
- Author(s)
  Meng L, Bai Z, He S, Mochizuki K, Purushe J, Sun H, Wang J, Yagita H, Mineishi S, Fung H, Yanik GA, Carcchio R, Fan X, Crisalli LM, Hexner EO, Reshef R, Zhang Y, Zhang Y
- Journal Title
  
  J Immunol
  
  Volume: 196 Pages: 1070-1080
- DOI
  10.4049/jimmunol.1501310
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290059
[Journal Article] Tumor eradication by cisplatin is sustained by CD80/86-mediated costimulation of CD8+ T cells.2016
- Author(s)
  Beyranvand Nejad E, van der Sluis TC, van Duikeren S, Yagita H, Janssen GM, van Veelen PA, Melief CJ, van der Burg SH, Arens R
- Journal Title
  
  Cancer Res
  
  Volume: 76(29) Pages: 6017-6029
- DOI
  10.1158/0008-5472.can-16-0881
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290059
[Journal Article] Concomitant targeting of programmed death-1 (PD-1) and CD137 improves the efficacy of radiotherapy in a mouse model of human BRAFV600-mutant melanoma.2016
- Author(s)
  Kroon P, Gadiot J, Peeters M, Gasparini A, Deken MA, Yagita H, Verheij M, Borst J, Blank CU, Verbrugge I
- Journal Title
  
  Cancer Immunol Immunother
  
  Volume: 65(6) Pages: 753-763
- DOI
  10.1007/s00262-016-1843-4
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290059
[Journal Article] Differential contribution of three immune checkpoint (VISTA, CTLA-4, PD-1) pathways to antitumor responses against squamous cell carcinoma.2016
- Author(s)
  Kondo Y, Ohno T, Nishii N, Harada K, Yagita H, Azuma M
- Journal Title
  
  Oral Oncol
  
  Volume: 57 Pages: 54-60
- DOI
  10.1016/j.oraloncology.2016.04.005
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26253086, KAKENHI-PROJECT-26290059
[Journal Article] Agonists of the TRAIL death receptor DR5 sensitize intestinal stem cells to chemotherapy-induced cell death and trigger gastrointestinal toxicity.2016
- Author(s)
  Finnberg, N. K., Gokare, P., Navaraj, A., Lang Luhs K. A., Cerniglia, G., Yagita, H., Takeda, K., Motoyama, N., and EL-Deiry, W. S.
- Journal Title
  
  Cancer Res
  
  Volume: 76 Pages: 700-712
- DOI
  10.1158/0008-5472.can-15-2759
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14410, KAKENHI-PROJECT-26290059
[Journal Article] SCIB1, a huIgG1 antibody DNA vaccination, combined with PD-1 blockade induced efficient therapy of poorly immunogenic tumors.2016
- Author(s)
  Xue W, Brentville VA, Symonds P, Cook KW, Yagita H, Metheringham RL, Durrant LG
- Journal Title
  
  Oncotarget
  
  Volume: 7(50) Pages: 83088-83100
- DOI
  10.18632/oncotarget.13070
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290059
[Journal Article] CD27 agonism plus PD-1 blockade recapitulates CD4+ T cell help in therapeutic anti-cancer vaccination.2016
- Author(s)
  Ahrends T, Babala N, Xiao Y, Yagita H, van Eenennaam H, Borst J
- Journal Title
  
  Cancer Res
  
  Volume: 76(10) Pages: 2921-2931
- DOI
  10.1158/0008-5472.can-15-3130
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290059
[Journal Article] Notch controls the survival of memory CD4+ T cells by regulating glucose uptake2015
- Author(s)
  Maekawa Y, Ishifune C, Tsukumo S, Hozumi K, Yagita H, Yasutomo K.
- Journal Title
  
  Nat Med
  
  Volume: 21 Pages: 55-61
- DOI
  10.1038/nm.3758
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590585, KAKENHI-PROJECT-26290059, KAKENHI-PROJECT-15K19131, KAKENHI-PLANNED-26110008, KAKENHI-PROJECT-26253063
[Journal Article] Rational conbination of immunotherapies with clinical efficacy in mice with advanced cancer.2015
- Author(s)
  Bransi A, Camilo Salgado O, Beffinger M, Milo K, Silina K, Yagita H, Becher B, Knuth A, van den Broek M
- Journal Title
  
  Cancer Immunol Res
  
  Volume: 3 Pages: 1279-1288
- DOI
  10.1158/2326-6066.cir-15-0103-t
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290059
[Journal Article] VEGF-A modulates expression of inhibitory checkpoints on CD8+ T cells in tumors.2015
- Author(s)
  Voron T, Colussi O, Marcheteau E, Pernot S, Nizard M, Pointet A, Latreche S, Bergaya S, Benhamouda N, Tanchot C, Stockmann C, Combe P, Berger A, Zinzindohoue F, Yagita H, Tartour E, Taieb J, Terme M
- Journal Title
  
  J Exp Med
  
  Volume: 212 Pages: 139-148
- DOI
  10.1084/jem.20140559
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26290059
[Journal Article] Immunomodulatory effect of peritumorally administered interferon-beta on melanoma through tumor-associated macrophages.2015
- Author(s)
  Kakizaki A, Fujimura T, Furudate S, Kambayashi Y, Yamauchi T, Yagita H, Aiba S
- Journal Title
  
  Oncoimmunology
  
  Volume: 4
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26290059
[Journal Article] The PTEN pathway in Treg is a critical driver of the suppressive tumor microenvironment.2015
- Author(s)
  Sharma MD, Shinde R, McGaha TL, Huang L, Holmgaard RB, Wolchok JD, Mautino MR, Celis E, Sharpe AH, Francisco LM, Powell JD, Yagita H, Mellor AL, Blazar BR, Munn DH
- Journal Title
  
  Sci Adv
  
  Volume: 1
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290059
[Journal Article] Combination immunotherapy with 4-1BB activation and PD-1 blockade enhances antitumor efficacy in a mouse model of subcutaneous tumor.2015
- Author(s)
  Shindo Y, Yoshimura K, Kuramasu A, Watanabe Y, Ito H, Kondo T, Oga A, Ito H, Yoshino S, Hazama S, Tamada K, Yagita H, Oka M
- Journal Title
  
  Anticancer Res
  
  Volume: 35 Pages: 129-136
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26290059
[Journal Article] Blockade of PD-1/PD-L1 promotes adoptive T-cell immunotherapy in a tolerogenic environment.2015
- Author(s)
  Blake SJ, Ching AL, Kenna TJ, Galea R, Large J, Yagita H, Steptoe RJ
- Journal Title
  
  PLoS One
  
  Volume: 10(3)
- DOI
  10.1371/journal.pone.0119483
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26290059
[Journal Article] Bortezomib improves adoptive T cell therapy by sensitizing cancer cells to FasL cytotoxicity.2015
- Author(s)
  Shanker A, Pellom ST, Dudimah DF, Thounaojam MC, de Kluiver RL, Brooks AD, Yagita H, McVicar DW, Murphy WJ, Longo DL, Sayers TJ
- Journal Title
  
  Cancer Res
  
  Volume: 75 Pages: 5260-5272
- DOI
  10.1158/0008-5472.can-15-0794
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290059
[Journal Article] Thymus-derived regulatory T cells restrain pro-inflammatory Th1 responses by downregulating CD70 on dendritic cells.2015
- Author(s)
  Dhainaut M, Coquerelle C, Uzureau S, Denoeud J, Acolty V, Oldenhove G, Galuppo A, Sparwasser T, Tielemans K, Pays E, Yagita H, Borst J, Moser M
- Journal Title
  
  EMBO J
  
  Volume: 34 Pages: 1336-1348
- DOI
  10.15252/embj.201490312
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290059
[Journal Article] CD70 and IFN-1 selectively induce Eomesdermin or T-bet and synergize to promote CD8+ T-cell responses.2015
- Author(s)
  Dong H, Franklin NA, Ritchea SB, Yagita H, Glennie MJ, Bullock TN
- Journal Title
  
  Eur J Immunol
  
  Volume: 45 Pages: 3289-3301
- DOI
  10.1002/eji.201445291
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290059
[Journal Article] Hes1 suppresses acute myeloid leukemia development through FLT3 repression.2015
- Author(s)
  Kato T, Sakata-Yanagimoto M, Nishikii H, Miyake Y, Yokayama Y, Asabe Y, Kamada Y, Ueno M, Obara N, Suzukawa K, Hasegawa Y, Kitabayashi I, Uchida K, Hirao A, Yagita H, Kageyama R, Chiba S
- Journal Title
  
  Leukemia
  
  Volume: 29 Pages: 576-585
- DOI
  10.1038/leu.2014.281
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390241, KAKENHI-PUBLICLY-25112703, KAKENHI-PROJECT-25860778, KAKENHI-PROJECT-26290059
[Journal Article] Piperine enhances the efficacy ofTRAIL-based therapy of triple-negative breast cancer cells.2014
- Author(s)
  Abdelhamad S, Yokoyama S, Refaat A, Ogura K, Yagita H, Awale S, Saiki I
- Journal Title
  
  Anticancer Res
  
  Volume: 34 Pages: 1893-1899
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26290059
[Journal Article] ER stress regulates myeloid-derived suppressor cell fate through TRAIL-R-mediated apoptosis.2014
- Author(s)
  Condamine T, Kumar V, Ramachandran IR, Youn J, Celis E, Finnberg N, El-Deiry WS, Winograd R, Vonderheide RH, English NR, Knight SC, Yagita H, McCaffrey JC, Antonia S, Hockstein N, Witt R, Masters G, Bauer T, Gabrilovich DI
- Journal Title
  
  J Clin Invest
  
  Volume: 124 Pages: 2626-2639
- DOI
  10.1172/jci74056
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26290059
[Journal Article] PD-1 blockade enhances T cell migration to tumors by elevating IFN-γ inducible chemokines2013
- Author(s)
  Berrien-Elliott MM, Jackson SR, Meyer JM, Rouskey CJ, Nguyen TL, Yagita H, Greenberg P, Dipaolo RJ, Teague RM
- Journal Title
  
  Cancer Res
  
  Volume: 73 Pages: 5209-5218
- DOI
  10.1158/0008-5472.can-12-2179
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240089
[Journal Article] The TWEAK receptor Fn14 is a therapeutic target in melanoma: Immunotoxins targeting Fn14 receptor for malignant melanoma treatment2013
- Author(s)
  Zhou H, Ekmekcioglu S, Marks JW, Mohamedali KA, Asrani K, Phillips KK, Brown SA, Cheng E, Weiss MB,Hittelman WN, Tran NL, Yagita H, Winkles JA, Rosenblum MG
- Journal Title
  
  J Invest Dermatol
  
  Volume: 133 Pages: 1052-1062
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240089
[Journal Article] Simultaneous blockade of programmed death 1 and vascular endothelial growth factor receptor 2 (VEGFR2) induces synergistic anti-tumour effect in vivo.2013
- Author(s)
  Yasuda S
- Journal Title
  
  Clin Exp Immunol
  
  Volume: 172 Pages: 500-506
- DOI
  10.1111/cei.12069
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390366, KAKENHI-PROJECT-22240089, KAKENHI-PROJECT-24591887
[Journal Article] Combined blockade of TIM-3 and TIM-4 augments cancer vaccine efficacy against established melanomas.2013
- Author(s)
  Baghdadi M, Nagao H, Yoshiyama H, Akiba H, Yagita H, Dosaka-Akita H, Jinushi M
- Journal Title
  
  Cancer Immunology, Immunotherapy
  
  Volume: 62 Pages: 629-37
- DOI
  10.1007/s00262-012-1371-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240089, KAKENHI-PUBLICLY-23130501, KAKENHI-PROJECT-23501283, KAKENHI-PROJECT-23590534, KAKENHI-PUBLICLY-25112701, KAKENHI-PUBLICLY-25130701, KAKENHI-PROJECT-25461503
[Journal Article] Host immunity contributes to the anti-melanoma activity of BRAF inhibitors.2013
- Author(s)
  Knight DA, Ngiow SF, Li M, Parmenter T, Mok S, Cass A, Haynes NM, Kinross K, Yagita H, Koya RC, Greber TG, Ribas A, McArthur GA, Smyth MJ
- Journal Title
  
  J Cin Invest
  
  Volume: 123 Pages: 1371-1381
- DOI
  10.1172/jci66236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240089
[Journal Article] Galectin-9-mediated protection from allo-specific T cells as a mechanism of immune privilege of corneal allografts.2013
- Author(s)
  Shimmura-Tomita M, Wang M, Taniguchi H, Akiba H, Yagita H, Hori J
- Journal Title
  
  PLoS One
  
  Volume: 8(5)
- DOI
  10.1371/journal.pone.0063620
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592619, KAKENHI-PROJECT-25461503
[Journal Article] Galectin-9-mediated protection from allo-specific T cells as a mechanism of immune privilege of corneal allografts2013
- Author(s)
  Machiko Shimmura-Tomita, Mingcong Wang, Hiroko Taniguchi, Hisaya Akiba, Hideo Yagita and Junko Hori.
- Journal Title
  
  PLOS ONE
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592619
[Journal Article] Induction of pro-apoptotic antibodies to triple negative breast cancer by vaccination with TRAIL death receptor DR5 DNA2012
- Author(s)
  Piechocki MP, Wu GS, Jones RF, Jacob JB, Gibson H, Ethier SP, Abrams1 J, Yagita H, Venuprasad K, Wei WZ
- Journal Title
  
  Int J Cancer
  
  Volume: 131 Pages: 2562-2572
- DOI
  10.1002/ijc.27534
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240089
[Journal Article] Epigenetic modulation enhances the therapeutic effect of anti-IL13Ralpha 2 antibody in human mesothelioma xenografts2012
- Author(s)
  Takenouchi M, Hirai S, Sakuragi N, Yagita H, Hamada H, Kato K
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 17 Pages: 2819-2829
- DOI
  10.1158/1078-0432.ccr-10-2986
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240089, KAKENHI-PROJECT-22390118
[Journal Article] Radiotherapy promotes tumor-specific effector CD8+ T cells via dendritic cell activation2012
- Author(s)
  Gupta A, Probst HC, Vuong V, Landshammer A, Muth S, Yagita H, Schwendener R, Pruschy M, Knuth A, van den Broek M
- Journal Title
  
  J Immunol
  
  Volume: 189 Pages: 558-566
- DOI
  10.4049/jimmunol.1200563
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240089
[Journal Article] Polyfunctional CD4+ T cells are essential for eradicating advanced B-cell lymphoma after chemotherapy2012
- Author(s)
  Ding ZC, Huang L, Blazar BR, Yagita H, Mellor AL, Munn DH, Zhou G
- Journal Title
  
  Blood
  
  Volume: 120 Pages: 2229-2239
- DOI
  10.1182/blood-2011-12-398321
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240089
[Journal Article] Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between thereceptor TIM-3 and the alarmin HMGB12012
- Author(s)
  Chiba, M. Baghdadi, H. Akiba, H. Yoshiyama, I. Kinoshita, H. Dosaka-Akita, Y. Fujioka, Y. Ohba, J. V. Gorman, J. D. Colgan, M. Hirashima, T. Uede, A. Takaoka, H. Yagita and M. Jinushi.
- Journal Title
  
  Nature Immunology
  
  Volume: 13 Pages: 832-42
- DOI
  10.1038/ni.2376
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J04616, KAKENHI-PROJECT-21390113, KAKENHI-PROJECT-22240089, KAKENHI-PROJECT-22590360, KAKENHI-PROJECT-22591098, KAKENHI-PROJECT-23390090, KAKENHI-PROJECT-23501283, KAKENHI-PROJECT-23590534, KAKENHI-PROJECT-23591132, KAKENHI-PROJECT-23659196, KAKENHI-PUBLICLY-23114501
[Journal Article] Cancer-Induced Immunosuppression: IL-18-Elicited Immunoablative NK Cells.2012
- Author(s)
  Terme M, Ullrich E, Aymeric L, Meinhardt K, Coudert J, Desbois M, Ghiringhelli F, Viaud S, Ryffel B, Yagita H, Chen L, Mecheri S, Kaplanski G, Prevost-Blondel A, Kato M, Schultze JL, Tartour E, Kroemer G, Degli-Esposti M, Chaput N, Zitvogel L
- Journal Title
  
  Cancer Res
  
  Volume: 72 Pages: 2757-2767
- DOI
  10.1158/0008-5472.can-11-3379
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240089, KAKENHI-PROJECT-23650241, KAKENHI-PROJECT-24390157, KAKENHI-PROJECT-24406002
[Journal Article] Aging-associated B7-DC(+) B cells enhance anti-tumor immunity viaTh1 and Th17 induction2012
- Author(s)
  Tomihara K, Shin T, Hurez VJ, Yagita H, Pardoll DM, Zhang B, Curiel TJ, Shin T
- Journal Title
  
  Aging Cell
  
  Volume: 11 Pages: 128-138
- DOI
  10.1111/j.1474-9726.2011.00764.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240089, KAKENHI-PROJECT-23890069
[Journal Article] ATM-Mediated DNA Damage Signals Mediate Immune Escape through Integrin-alphavbeta3-Dependent Mechanisms2012
- Author(s)
  Jinushi M
- Journal Title
  
  Cancer Research
  
  Volume: 72 Pages: 56-65
- DOI
  10.1158/0008-5472.can-11-2028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390113, KAKENHI-PROJECT-21689031, KAKENHI-PROJECT-22240089, KAKENHI-PUBLICLY-23130501, KAKENHI-PROJECT-23590534, KAKENHI-PROJECT-23591132
[Journal Article] Radiotherapy increases the permissiveness of established mammary tumors to rejection by immunomodulatory antibodies2012
- Author(s)
  Verbrugge I, Hagekyriakou J, Sharp LL, Galli M, West AC, McLaughlin NM, Duret H, Yagita H, Johnstone RW, Smyth MJ, Haynes NM
- Journal Title
  
  Cancer Res
  
  Volume: 72 Pages: 3163-3174
- DOI
  10.1158/0008-5472.can-12-0210
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240089
[Journal Article] The CD4+ T-cell help signal is transmitted from APC to CD8+ T-cells via CD27-CD70 interactions2012
- Author(s)
  Feau S, Garcia Z, Arens R, Yagita H, Borst J, Schoenberger SP
- Journal Title
  
  Nat Commun
  
  Volume: 3 Pages: 948-948
- DOI
  10.1038/ncomms1948
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240089
[Journal Article] Anti-tumor activities and on-target toxicities mediated by TRAIL receptor agonist following co-treatment with panobinostat2011
- Author(s)
  Martin BP, J Frew A, Bots M, Fox S, Long F, Takeda K, Yagita H, Atadja P, Smyth MJ, Johnstone RW
- Journal Title
  
  Int J Cancer
  
  Volume: 128 Pages: 2735-2747
- DOI
  10.1002/ijc.25594
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240089
[Journal Article] Combination of lentivector immunization and low dose chemotherapy or PD-1/PD-L1 blocking primes self-reactive T cells and induces anti-tumor immunity2011
- Author(s)
  Sierro SR, Donda A, Perret R, Guillaume P, Yagita H, Levy F, Romero P
- Journal Title
  
  Eur J Immunol
  
  Volume: 41 Pages: 2217-2228
- DOI
  10.1002/eji.201041235
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240089
[Journal Article] TLR2-dependent induction of IL-10 and Foxp3^+CD25^+CD4^+ regulatory T cells prevents effective anti- tumor immunity induced by Pam2 lipopeptides in vivo2011
- Author(s)
  Yamazaki, S., K. Okada, A. Maruyama, M. Matsumoto, and T. Seya.
- Journal Title
  
  PLoS ONE
  
  Volume: 6(4)
- DOI
  10.1371/journal.pone.0018833
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22114008, KAKENHI-PROJECT-22240089, KAKENHI-PROJECT-23390088, KAKENHI-PROJECT-23390120, KAKENHI-PROJECT-23590558
[Journal Article] Therapeutic potential of the TWEAK/Fn14 pathway in intractable gastrointestinal cancer2011
- Author(s)
  Yoriki R, Akashi S, Sho M, Nomi T, Yamato I, Hotta K, Takayama T, Matsumoto S, Wakatsuki K, Migita K, Yagita H, Nakajima Y
- Journal Title
  
  Exp Ther Med
  
  Volume: 2 Pages: 103-108
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/22977477
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240089
[Journal Article] FOXO3 programs tumor-associated DCs to become tolerogenic in human and murine prostate cancer2011
- Author(s)
  Watkins SK, Zhu Z, Riboldi E, Shafer-Weaver KA, Stagliano KE, Sklavos MM, Ambs S, Yagita H, Hurwitz AA
- Journal Title
  
  J Clin Invest
  
  Volume: 121 Pages: 1361-1372
- DOI
  10.1172/jci44325
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240089
[Journal Article] Anti-TIM3 antibody promotes T cell IFN-gamma-mediated antitumor immunity and suppresses established tumors2011
- Author(s)
  Ngiow SF, von Scheidt B, Akiba H, Yagita H, Teng MW, Smyth MJ
- Journal Title
  
  Cancer Res
  
  Volume: 71 Pages: 3540-3551
- DOI
  10.1158/0008-5472.can-11-0096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240089, KAKENHI-PROJECT-22591098
[Journal Article] Tumor-associated macrophages regulate tumorigenicity and anti-cancer drug responses of cancer stem/initiating cells.2011
- Author(s)
  Jinushi M, Chiba S, Yoshiyama H, Masutomi K, Kinoshita I, Dosaka-Akita H, Yagita H, Takaoka A, Tahara H
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 108 Pages: 112425-12430
- DOI
  10.1073/pnas.1106645108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249069, KAKENHI-PROJECT-21689031, KAKENHI-PROJECT-22240089, KAKENHI-PUBLICLY-23130501, KAKENHI-PROJECT-23590534, KAKENHI-PROJECT-23591132
[Journal Article] Development and characterization of a potent immunoconjugate targeting the Fn14 receptor on solid tumor cells2011
- Author(s)
  Zhou H, Marks JW, Hittelman WN, Yagita H, Cheung LH, Rosenblum MG, Winkles JA
- Journal Title
  
  Mol Cancer Ther
  
  Volume: 10 Pages: 1276-1288
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240089
[Journal Article] Importin beta1 Protein-mediated Nuclear Localization of Death Receptor 5 (DR5) Limits DR5/Tumor Necrosis Factor (TNF)-related Apoptosis-inducing Ligand (TRAIL)-induced Cell Death of Human Tumor Cells2011
- Author(s)
  Kojima Y, Nakayama M, Nishina T, Nakano H, Koyanagi M, Takeda K, Okumura K, Yagita H
- Journal Title
  
  JOURNAL OF BIOLOGICAL CHEMISTRY
  
  Volume: 286 Pages: 43383-43393
- DOI
  10.1074/jbc.m111.309377
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240089, KAKENHI-PUBLICLY-23112519, KAKENHI-PUBLICLY-23117717, KAKENHI-PROJECT-23300355, KAKENHI-PROJECT-23390260, KAKENHI-PROJECT-23659404
[Journal Article] IL-18 induces PD-1-dependent immunosuppression in cancer.2011
- Author(s)
  Terme M, Ullrich E, Aymeric L, Meinhardt K, Desbois M, Delahaye NF, Viaud S, Ryffel B, Yagita H, Kaplanski G, Prevost-Blondel A, Kato M, Schultze JL, Tartour E, Kroemer G, Chaput N, Zitvogel L
- Journal Title
  
  Cancer Res.
  
  Volume: 71 Pages: 5412-5422
- DOI
  10.1158/0008-5472.can-11-0993
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240089, KAKENHI-PROJECT-23650241
[Journal Article] Anti-ErbB-2 mAb therapy requires type I and II interferons and synergizes with anti-PD-1 or anti-CD137 mAb therapy2011
- Author(s)
  Stagg J, Loi S, Divisekera U, Ngiow SF, Duret H, Yagita H, Teng MW, Smyth MJ
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 108 Pages: 7142-7147
- DOI
  10.1073/pnas.1016569108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240089
[Journal Article] PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors2010
- Author(s)
  Sakanishi T, Yagita H
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 393 Pages: 4275-4280
- DOI
  10.1016/j.bbrc.2010.02.092
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240089
[Journal Article] Blockade of programmed death-1 pathway rescues the effector function of tumor-infiltrating T cells and enhances the antitumor efficacy of lentivector immunization2010
- Author(s)
  Zhou Q, Xiao H, Liu Y, Peng Y, Hong Y, Yagita H, Chandler P, Munn DH, Mellor A, Fu N, He Y
- Journal Title
  
  J Immunol
  
  Volume: 185 Pages: 5082-5092
- DOI
  10.4049/jimmunol.1001821
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240089
[Journal Article] Tumor-reactive CD4+ T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts.2010
- Author(s)
  Quezada SA, Simpson TR, Peggs KS, Merghoub T, Vider J, Fan X, Blasberg R, Yagita H, Muranski P, Antony PA, Restifo NP, Allison JP
- Journal Title
  
  J Exp Med 207
  
  Pages: 637-650
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016071
[Journal Article] Notch2 signaling is required for potent antitumor immunity in vivo2010
- Author(s)
  Sugimoto K, Maekawa Y, Kitamura A, Nishida J, Koyanagi A, Yagita H, Kojima H, Chiba S, Shimada M, Yasutomo K
- Journal Title
  
  J Immunol
  
  Volume: 184 Pages: 4673-4678
- DOI
  10.4049/jimmunol.0903661
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20679005, KAKENHI-PROJECT-21590536, KAKENHI-PROJECT-22240089
[Journal Article] PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors.2010
- Author(s)
  Curran MA, Montalvo W, Yagita H, Allison JP
- Journal Title
  
  Proc Natl Acad Sci USA 107
  
  Pages: 4275-4280
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016071
[Journal Article] Optimized combination therapy using bortezomib, TRAIL and TLR agonists in established breast tumors2010
- Author(s)
  Lee S, Yagita H, Sayers TJ, Celis E
- Journal Title
  
  Cancer Immunol Immunother
  
  Volume: 59 Pages: 1073-1081
- DOI
  10.1007/s00262-010-0834-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240089
[Journal Article] Targeting antigen to diverse APCs inactivates memory CD8+ T cells without eliciting tissue-destructive effector function.2010
- Author(s)
  Kenna TJ, Waldie T, McNally A, Thomson M, Yagita H, Thomas R, Steptoe RJ
- Journal Title
  
  J Immunol 184
  
  Pages: 598-606
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016071
[Journal Article] Spatiotemporal basis of CTLA-4 costimulatory molecule-mediated negative regulation of T cell activation2010
- Author(s)
  Yokosuka T, Kobayashi W, Takamatsu M, Sakata-Sogawa K, Zeng H, Yagita H, Tokunaga M, Saito T
- Journal Title
  
  Immunity
  
  Volume: Vol.33 Pages: 326-339
- DOI
  10.1016/j.immuni.2010.09.006
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20114004, KAKENHI-PROJECT-22240089
[Journal Article] Anti-tumor effects of depleting and non-depleting anti-CD27 monoclonal antibodies in immune-competent mice.2010
- Author(s)
  Sakanishi T, Yagita H
- Journal Title
  
  Biochem Biophys Res Commun 393
  
  Pages: 829-835
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016071
[Journal Article] Blockade of delta-like ligand 4signaling inhibits both growth and angiogenesis of pancreatic cancer2010
- Author(s)
  Oishi H, Sunamura M. Egawa S, Motoi F, Unno M, Furukawa T, Habib NA, Yagita H
- Journal Title
  
  Pancreas
  
  Volume: 39 Pages: 897-903
- DOI
  10.1097/mpa.0b013e3181ce7185
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240089, KAKENHI-PROJECT-22390253, KAKENHI-PROJECT-22591512
[Journal Article] DNAM-1/CD155 interactions promote cytokine NK cell-mediated suppression of poorly immunogenic melanoma metastasis.2010
- Author(s)
  Chan CJ, Andrew DM, McLaughlin NM, Yagita H, Gilfillan S, Colonna M, Smyth MJ
- Journal Title
  
  J Immunol 184
  
  Pages: 902-911
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016071
[Journal Article] Darcy PK, Smyth MJ: CD11c+ dendritic cells and B cells contribute to the tumoricidal activity of anti-DR5 antibody therapy in established tumors2010
- Author(s)
  Haynes NM, Hawkins ED, Li M, McLaughlin NM, Hammerling GJ, Schwendener R, Winoto A, Wensky A, Yagita H, Takeda K, Kershaw MH
- Journal Title
  
  J Immunol
  
  Volume: 185 Pages: 532-541
- DOI
  10.4049/jimmunol.0903624
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240089
[Journal Article] DNAM-1/CD155 interactions promote cytokine NK cell-mediated suppression of poorly immunogenic melanoma metastasis2010
- Author(s)
  Chan CJ, Andrew DM, McLaughlin NM, Yagita H, Gilfillan S, Colonna M, Smyth MJ
- Journal Title
  
  J Immunol
  
  Volume: 184 Pages: 902-911
- DOI
  10.4049/jimmunol.0903225
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240089
[Journal Article] Control of established melanoma by CD27 stimulation is associated with enhanced effector function and persistence,and reduced PD-1 expression of tumor infiltrating CD8+ T cells2010
- Author(s)
  Roberts DJ, Franklin NA, Kingeter LM, Yagita H, Tutt AL, Glennie MJ, Bullock TN
- Journal Title
  
  J Immunother
  
  Volume: 33 Pages: 769-779
- DOI
  10.1097/cji.0b013e3181ee238f
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240089
[Journal Article] Peptide vaccine induces enhanced tumor growth associated with apoptosis induction in CD8+ T cells2010
- Author(s)
  Muraoka D, Kato T, Wang L, Maeda Y, Noguchi T, Harada N, Takeda K, Yagita H, Guillaume P, Luescher I, Old LJ, Shiku H, Nishikawa H
- Journal Title
  
  J Immunol
  
  Volume: 185 Pages: 3768-3776
- DOI
  10.4049/jimmunol.0903649
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240089
[Journal Article] Optimized combination therapy using bortezomib, TRAIL and TLR agonists in established breast tumors.2010
- Author(s)
  Lee S, Yagita H, Sayers TJ, Celis E
- Journal Title
  
  Cancer Immunol Immunother (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016071
[Journal Article] Tumor-reactive CD4+ T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts2010
- Author(s)
  Quezada SA, Simpson TR, Peggs KS, Merghoub T, Vider J, Fan X, Blasberg R, Yagita H, Muranski P, Antony PA, Restifo NP, Allison JP
- Journal Title
  
  J Exp Med
  
  Volume: 207 Pages: 637-650
- DOI
  10.1084/jem.20091918
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240089
[Journal Article] Combination therapy of established tumors by antibodies targeting immune activating and suppressing molecules2010
- Author(s)
  Takeda K, Kojima Y, Uno T, Hayakawa Y, Teng MWL, Yoshizawa H, Yagita H, Geyjo F, Okumura K, Smyth MJ
- Journal Title
  
  J Immunol
  
  Volume: 184 Pages: 5493-5501
- DOI
  10.4049/jimmunol.0903033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240089
[Journal Article] Antigen presented by tumors in vivo determines the nature of CD8+ T cell cytotoxicity.2009
- Author(s)
  Shanker A, Brooks AD, Jacobsen KM, Wine JW, Wiltrout RH, Yagita H, Sayers TJ
- Journal Title
  
  Cancer Res 69
  
  Pages: 6615-6623
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016071
[Journal Article] PD-1/PD-L blockade prevents anergy induction and enhances the anti-tumor activities of glycolipid-activated invariant NKT cells.2009
- Author(s)
  Parekh VV, Lalani S, Kim S, Halder R, Azuma M, Yagita H, Kumar V, Wu L, Kaer LV
- Journal Title
  
  J Immunol 182
  
  Pages: 2816-2826
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016071
[Journal Article] NKG2A inhibits invariant NKT cell activation in hepatic injury.2009
- Author(s)
  Kawamura T, Takeda K, Kaneda H, Matsumoto H, Hayakawa Y, Raulet DH, Ikarashi Y, Kronenberg M, Yagita H, Kinoshita K, Abo T, Okumura K, Smyth MJ
- Journal Title
  
  J Immunol 182
  
  Pages: 250-258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016071
[Journal Article] Clinical importance of B7-H3 expression in human pancreatic cancer.2009
- Author(s)
  Yamato I, Sho M, Nomi T, Akahori T, Shimada K, Hotta K, Kanehiro H, Konishi N, Yagita H, Nakajima Y
- Journal Title
  
  Br J Cancer 101
  
  Pages: 1709-1716
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016071
[Journal Article] Recall responses by helpless memory CD8+ T cells are restricted by the up-regulation of PD-1.2009
- Author(s)
  Fuse S, Tsai C, Molloy MJ, Allie SR, Zhang W, Yagita H, Usherwood EJ
- Journal Title
  
  J Immunol 182
  
  Pages: 4244-4254
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016071
[Journal Article] Blockade of B7-H1 or B7-DC induces an anti-tumor effect in a mouse pancreatic cancer model.2009
- Author(s)
  Okudaira K, Hokari R, Tsuzuki Y, Okada Y, Komoto S, Watanabe C, Kurihara C, Kawaguchi A, Nagao S, Azuma M, Yagita H, Miura S
- Journal Title
  
  Int J Oncol 35
  
  Pages: 741-749
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016071
[Journal Article] Tim-3 mediates phagocytosis of apoptotic cells and the cross-presentation.2009
- Author(s)
  Nakayama M, Akiba H, Takeda K, Kojima Y, Hashiguchi M, Azuma M, Yagita H, Okumura K
- Journal Title
  
  Blood 113
  
  Pages: 3821-3830
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016071
[Journal Article] Antibodies targeted to TRAIL receptor-2 and ErbB-2 synergize in vivo and induce an antitumor immune response.2008
- Author(s)
  Stagg J, Sharkey J, Pommey S, Young R, Takeda K, Yagita H, Johnstone RW, Smyth MJ
- Journal Title
  
  Proc Natl Acad Sci USA 105
  
  Pages: 16254-16259
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016071
[Journal Article] CD4+CD25+ Tregs control the TRAIL-dependent cytotoxicity of tumor-infiltrating DCs in rodent models of colon cancer.2008
- Author(s)
  Roux S, Apetoh L, Chalmin F, Ladoire S, Mignot G, Puig PE, Lauvau G, Zitvogel L, Martin F, Chauffert B, Yagita H, Solary E, Ghiringhelli F
- Journal Title
  
  J Clin Invest 118
  
  Pages: 3751-3761
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016071
[Journal Article] Watanabe Blockade of NKG2D signaling prevents the development of murine CD4+ T cell-mediated colitis2008
- Author(s)
  Ito, Y., T., Kanai, T., Totsuka, R., Okamoto, K., Tsuchiya, Y., Nemoto, A., Yoshioka, T., Tomita, T., Nagaishi, N., Sakamoto, T., Sakanishi, K., Okumura, H., Yagita, M
- Journal Title
  
  American journal of physiology 294
  
  Pages: 199-207
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390292
[Journal Article] Combination therapy of established cancer using a histone deacetylase inhibitor and a TRAIL receptor agonisit.2008
- Author(s)
  Frew AJ, Lindemann RK, Martin BP, Clarke CJP, Sharkey J, Anthony DA, Banks KM, Haynes NM, Gangatirkar P, Stanley K, Bolden JE, Takeda K, Yagita H, Secrist JP, Smyth MJ, Johnstone RW
- Journal Title
  
  Proc Natl Acad Sci USA 105
  
  Pages: 11317-11322
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016071
[Journal Article] Interleukin 21 enhances antibody-mediated tumor rejection.2008
- Author(s)
  Smyth MJ, Teng MWL, Sharkey J, Westwood JA, Haynes NM, Yagita H, Takeda K, Sivakumar PV, Kershaw MH
- Journal Title
  
  Cancer Res 68
  
  Pages: 3019-3025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016071
[Journal Article] Dendritic cell-mediated NK cell activation is controlled by Jagged2-Notch interaction.2008
- Author(s)
  Kijima M, Yamaguchi T, Isifune C, Maekawa Y, Koyanagi A, Yagita H, Chiba S, Kishihara K, Shimada M, Yasutomo K
- Journal Title
  
  Proc Natl Acad Sci USA 105
  
  Pages: 7010-7015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016071
[Journal Article] Differential effector mechanisms induced by vaccination with MUC1 DNA in the rejection of colon carcinoma growth at orthotopic sites and metastases.2008
- Author(s)
  Sugiura D, Aida S, Denda-Nagai K, Takeda K, Kamata-Sakurai M, Yagita H, Irimura T
- Journal Title
  
  Cancer Sci 99
  
  Pages: 2477-2484
- NAID
  10024014429
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016071
[Journal Article] Programmed death-1/programmed death ligand 1 interaction regulates the induction and maintenance of invariant NKT cell anergy.2008
- Author(s)
  Chang WS, Kim JY, Kim YJ, Kim YS, Lee JM, Azuma M, Yagita H, Kang CY
- Journal Title
  
  J Immunol 181
  
  Pages: 6707-6710
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016071
[Journal Article] Combination of treatment with death receptor 5-specific antibody with therapeutic HPV DNA vaccination generates enhanced therapeutic anti-tumor effects.2008
- Author(s)
  Tseng CW, Trimble C, Monie C, Alvarez RD, Huh WK, Buchsbaum DJ, Straughn JM, Wang MC, Yagita H, Hung CF, Wu TC
- Journal Title
  
  Vaccine 26
  
  Pages: 4314-4319
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016071
[Journal Article] Death receptor 5-mediated apoptosis contributes to cholestatic liver disease.2008
- Author(s)
  Takeda K, Kojima Y, Ikejima K, Harada K, Yamashina S, Okumura K, Aoyama T, Frese F, Ikeda H, Haynes NM, Cretney E, Yagita H, Sueyoshi N, Sato N, Nakanuma Y, Smyth MJ, Okumura K
- Journal Title
  
  Proc Natl Acad Sci USA 105
  
  Pages: 10895-10900
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016071
[Journal Article] Notch2 integrates signaling by the transcriptional factors RBP-J and CREB1 to promote T cell cytotoxicity.2008
- Author(s)
  Maekawa Y, Minato Y, Ishifune C, Kurihara T, Kitamura A, Kojima H, Yagita H, Sakata-Yanagimoto M, Saito T, Taniuchi I, Chiba S, Sone S, Yasutomo K
- Journal Title
  
  Nature Immunol 9
  
  Pages: 1140-1147
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016071
[Journal Article] Downregulation of c-FLIP promotes caspase-dependent JNK activation and reactive oxygen species accumulation in tumor cells2008
- Author(s)
  Nakajima, A., Y., Kojima, M., Nakayama, H., Yagita, K., Okumura, H., Nakano
- Journal Title
  
  Oncogene 27
  
  Pages: 76-84
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390292
[Journal Article]2008
- Author(s)
  Takeda K, Kojima Y, Ikejima K, Harada K, Yamashina S, Okumura K, Aoyama T, Fress S, Ikeda H, Hynes NM, Cretney E, Yagita H, Sueyoshi N, Sato N, Nakanuma Y, Smyth MJ, Okumura K
- Journal Title
  
  Proc Natl Sci USA 105(31)
  
  Pages: 10895-10900
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590257
[Journal Article] Treating metastatic solid tumors with bortezomib and a tumor necrosis factor-related apoptosis-inducing ligand receptor agonist antibody.2008
- Author(s)
  Shanker A, Brooks AD, Tristan CA, Wine JW, Elliot PJ, Yagita H, Takeda K, Smyth MJ, Murphy WJ, Sayers TJ
- Journal Title
  
  J. Natl. Cancer Inst 100
  
  Pages: 649-662
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016071
[Journal Article] Death receptor 5 mediated-apoptosis contributes to cholestatic liver disease.2008
- Author(s)
  Takeda K, Kojima Y, Ikejima K, Harada K, Yamashina S, Okumura K, Aoyama T, Frese s, Ikeda H, Hynes NM, Cretney E, Yagita H, Sueyoshi N, Sato N, Nakanuma Y, Smyth MJ, Okumura K
- Journal Title
  
  Proc Natl Acad Sci U S A 105(31)
  
  Pages: 10895-10900
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590257
[Journal Article] Targeting death-inducing receptors in cancer therapy2007
- Author(s)
  Takeda, K., J., Stagg, H., Yagita, K., Okumura, M. J., Smyth
- Journal Title
  
  Oncogene 26
  
  Pages: 3745-3757
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390292
[Journal Article] A subset of dendritic cells induces CD4+ T cells to produce IFN-□by an IL-12-independent but CD70-dependent mechanism in vivo.2007
- Author(s)
  Soares H, Waechter H, Glaichenhaus N, Mougneau E, Yagita H, Mizenina O, Dudziak D, Nussenzweig MC, Steinman RM
- Journal Title
  
  J Exp Med 204
  
  Pages: 1095-1106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016071
[Journal Article] Priming of CD8+ T cell responses by pathogens typically depends on CD70-mediated interactions with dendritic cells.2007
- Author(s)
  Schildknecht A, Miescher I, Yagita H, van den Broek M
- Journal Title
  
  Eur J Immunol 37
  
  Pages: 716-728
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016071
[Journal Article] Antibodies to T-cell Ig and mucin domain-containing proteins(Tim)-1 and -3 suppress the induction and progression of murine allergic conjunctivitis2007
- Author(s)
  Fukushima, A., T., Sumi, K., Fukuda, N., Kumagai, T., Nishida, H., Akiba, K., Okumura, H., Yagita, H., Ueno
- Journal Title
  
  Biochemical and biophysical research communications 353
  
  Pages: 211-216
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390292
[Journal Article] Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function.2007
- Author(s)
  Xiao S, Najafian N, Reddy J, Albin M, Zhu C, Jensen E, Imitola J, Korn T, Anderson AC, Zhang Z, Gutierrez C, Moll T, Sobel RA, Umetsu DT, Yagita H, Akiba H, Strom T, Sayegh MH, DeKruyff RH, Khoury SJ, Kuchroo VK
- Journal Title
  
  J Exp Med 204
  
  Pages: 1691-1702
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016071
[Journal Article] Tageting death-inducing receptors in cancer therapy.2007
- Author(s)
  Takeda K, Stagg J, Yagita H, Okumura K, Smyth MJ
- Journal Title
  
  Oncogene 26
  
  Pages: 3745-3757
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016071
[Journal Article] Clinical significance and therapeutic potential of the programmed death-1 ligand/programmed death-1 pathway in human pancreatic cancer.2007
- Author(s)
  Nomi T, Sho M, Akahori T, Hamada K, Kubo A, Kanehiro H, Nakamura S, Enomoto K, Yagita H, Azuma M, Nakajima Y
- Journal Title
  
  Clin Cancer Res 13
  
  Pages: 2151-2157
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016071
[Journal Article] Combined TLR/CD40 stimulation mediates potent immunity by regulating dendritic cell expression of CD70 in vivo.2007
- Author(s)
  Sanchez PJ, McWilliams JA, Haluszczak C, Yagita H, Kedl RM
- Journal Title
  
  J Immunol 178
  
  Pages: 1564-1572
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016071
[Journal Article] T-cell Ig and mucin domain-containing protein(Tim)-2 regulates murine allergic conjunctivitis during the effector phase2007
- Author(s)
  Fukushima, A., T., Sumi, K., Fukuda, N., Kumagai, T., Nishida, K., Okumura, H., Akiba, H., Yagita, H., Ueno
- Journal Title
  
  Immunology letters 110
  
  Pages: 133-138
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390292
[Journal Article] Blockade of the OX40ligand prolongs corneal allograft survival2007
- Author(s)
  Hattori, T., Y., Usui, Y., Okunuki, Y., Sonoda, M., Usui, E., Takada, J., Mizuguchi, H., Yagita, K., Okumura, H., Akiba, M., Takeuchi
- Journal Title
  
  European journal of immunology 37
  
  Pages: 3597-3604
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390292
[Journal Article] Perforin activity and immune homeaostasis: the common A91V polymorphism in perforin results in both pre- and post-synaptic defects in function.2007
- Author(s)
  Voskoboinik I, Sutton VR, Ciccone A, House C, Chia J, Darcy PK, Yagita H, Trapani JA
- Journal Title
  
  Blood 110
  
  Pages: 1184-1190
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016071
[Journal Article] B7-H3 regulates the development of experimental allergic conjunctivitis in mice2007
- Author(s)
  Fukushima, A., T., Sumi, K., Fukuda, N., Kumagai, T., Nishida, T., Yamazaki, H., Akiba, K., Okumura, H., Yagita, H., Ueno
- Journal Title
  
  Immunology letters 113
  
  Pages: 52-57
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390292
[Journal Article] Combined natural killer T-cell-based immunotherapy eradicates established tumors in mice.2007
- Author(s)
  Teng MWL, Westwood JA, Darcy PK, Sharkey J, Tsuji M, Franck RW, Porcelli SA, Besra GS, Takeda K, Yagita H, Kershaw MH, Smyth MJ
- Journal Title
  
  Cancer Res 67
  
  Pages: 7495-7504
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016071
[Journal Article] TNF receptor-associated factor 2-dependent canonical pathway is crucial for the development of Peyer's patches2007
- Author(s)
  Piao, J. H., H., Yoshida, W. C., Yeh, T., Doi, X., Xue, H., Yagita, K., Okumura, H., Nakano
- Journal Title
  
  J lmmunol 178
  
  Pages: 2272-2277
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390292
[Journal Article] Roles of programmed death-1(PD-1)/PD-1 ligands pathway in the development of murine acute myocarditis caused by coxsackievirus B32007
- Author(s)
  Seko, Y., H., Yagita, K., Okumura, M., Azuma, R., Nagai
- Journal Title
  
  Cardiovascular research 75
  
  Pages: 158-167
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390292
[Journal Article] Involvement of TNF-like weak inducer of apoptosis in the pathogenesis of collagen-induced arthritis2006
- Author(s)
  Kamata, K., S., Kamijo, A., Nakajima, A., Koyanagi, H., Kurosawa, H., Yagita, K., Okumura
- Journal Title
  
  J lmmunol 177
  
  Pages: 6433-6439
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390292
[Journal Article] 2006. Ameliorating effect of saporin-conjugated anti-CD llb monoclonal antibody in a murine T-cell-mediated chronic colitis2006
- Author(s)
  Kanai, T., K., Uraushihara, T., Totsuka, Y., Nemoto, R., Fujii, T., Kawamura, S., Makita, D., Sawada, H., Yagita, K., Okumura, M., Watanabe
- Journal Title
  
  Journal of gastroenterology and hepatology 21
  
  Pages: 1136-1142
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390292
[Journal Article] IL-21 enhances tumor-specific CTL induction by anti-DR5 antibody therapy.2006
- Author(s)
  Smyth MJ, Hayakawa Y, Cretney E, Zerafa N, Sivakumar P, Yagita H, Takeda K
- Journal Title
  
  J Immunol 176
  
  Pages: 6347-6355
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016071
[Journal Article] Eradication of established tumors in mice by a combination antibody-based therapy.2006
- Author(s)
  Uno T, Takeda K, Kojima Y, Yoshizawa H, Akiba H, Mittler RS, Gejyo F, Okumura K, Yagita H, Smyth MJ
- Journal Title
  
  Nature Med 12
  
  Pages: 693-698
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016071
[Journal Article] Preferential involvement of Tim-3 in the regulation of hepatic CD8+ T cells in murine acute graft-versus-host disease2006
- Author(s)
  Oikawa, T., Y., Kamimura, H., Akiba, H., Yagita, K., Okumura, H., Takahashi, M., Zeniya, H., Tajiri, M., Azuma
- Journal Title
  
  J lmmuno 1177
  
  Pages: 4281-4287
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390292
[Journal Article] 2006. B7-Hi-induced apoptosis as a mechanism of immune privilege of corneal allografts2006
- Author(s)
  Hori, J., M., Wang, M., Miyashita, K., Tanemoto, H., Takahashi, T., Takemori, K., Okumura, H., Yagita, M., Azuma
- Journal Title
  
  J lmmunol 177
  
  Pages: 5928-5935
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390292
[Journal Article] 2006. Eradication of established tumors in mice by a combination antibody-based therapy2006
- Author(s)
  Uno, T., K., Takeda, Y., Kojima, H., Yoshizawa, H., Akiba, R. S., Mittler, F., Gejyo, K., Okumura, H., Yagita, M. J., Smyth
- Journal Title
  
  Nature medicine 12
  
  Pages: 693-698
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390292
[Journal Article] Amelioration of bone loss in collagen-induced arthritis by neutralizing anti-RANKL monoclonal antibody2006
- Author(s)
  Kamijo, S., A., Nakajima, K., Ikeda, K., Aoki, K., Ohya, H., Akiba, H., Yagita, K., Okumura
- Journal Title
  
  Biochemical and biophysical research communications 347
  
  Pages: 124-132
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390292
[Journal Article] B7-H1-induced apoptosis as a mechanism of immune privilege of corneal allografts.2006
- Author(s)
  Hori J, Wang M, Miyashita M, Tanemoto K, Takahashi H, Takemori T, Okumura K, Yagita H, Azuma M
- Journal Title
  
  J Immunol 177
  
  Pages: 5928-5935
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016071
[Journal Article] Development of a whole cell vaccine for acute myeloid leukaemia2006
- Author(s)
  Cheuk, A., T., L., Chan, B., Czepulkowski, S. A., Berger, H., Yagita, K., Okumura, F., Farzaneh, G. J., Mufti, B. A., Guinn
- Journal Title
  
  Cancer Immunol Immunother 55
  
  Pages: 68-75
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390292
[Journal Article] Programed death (PD) ligand-1/PD-1 interaction is required for CD8+ T cell tolerance to tissue antigens.2006
- Author(s)
  Martin-Orozco N, Wang Y, Yagita H, Dong C
- Journal Title
  
  J Immunol 177
  
  Pages: 8291-8295
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016071
[Journal Article] A novel dendritic cell subset involved in tumor immunosurveillance.2006
- Author(s)
  Taieb J, Chaput N, Menard C, Apetoh L, Ullrich E, Bonmort M, Pequignot M, Casares N, Terme M, Flament C, Opolon P, Lecluse Y, Metivier G, Tomasello E, Vivier E, Ghiringhelli F, Martin F, Klatzmann D, Poynard T, Tursz T, Raposo G, Yagita H, Ryffel B, Kroemer G, Zitvogel L
- Journal Title
  
  Nature Med 12
  
  Pages: 214-219
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016071
[Journal Article] Resistance of infant leukemia with MLL rearrangement to tumor necrosis factor-related apoptosis-inducing ligand : a possible mechanism for poor sensitivity to antitumor immunity2006
- Author(s)
  Inukai, T., X., Zhang, M., Goto, K., Hirose, K., Uno, K., Akahane, A., Nemoto, K., Goi, H., Sato, K., Takahashi, H., Honna, K., Kagami, K., Nakamoto, H., Yagita, K., Okumura, T., Koyama-Okazaki, S., Nakazawa, K., Sugita
- Journal Title
  
  Leukemia 20
  
  Pages: 2119-2129
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390292
[Journal Article] An antiapoptotic protein, c-FLIPL, directly binds to MKK7 and inhibits the JNK pathway2006
- Author(s)
  Nakajima, A., S., Komazawa-Sakon, M., Takekawa, T., Sasazuki, W. C., Yeh, H., Yagita, K., Okumura, H., Nakano
- Journal Title
  
  The EMBO journal 25
  
  Pages: 5549-5559
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390292
[Journal Article] TWEAK mediates anti-tumor effect of tumor-infiltrating macrophage.2005
- Author(s)
  Kaduka Y, Takeda K, Nakayama M, Kinoshita K, Yagita H, Okumura K
- Journal Title
  
  Biochem Biophys Res Commun 331
  
  Pages: 384-390
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016071
[Journal Article] Beta2-microglobulin required for cell surface expression of blastocyst MHC.2005
- Author(s)
  Tanaka, T., T Ebata, A.Tajima, K.Kinoshita, K.Okumura, H.Yagita
- Journal Title
  
  Biochem Biophys Res Commun 332
  
  Pages: 311-317
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390120
[Journal Article] IFN-gamma-mediated negative feedback regulation of NKT-cell function by CD94/NKG2.2005
- Author(s)
  Ota, T., K.Takeda, H.Akiba, Y.Hayakawa, K.Ogasawara, Y.Ikarashi, S.Miyake, H.Wakasugi, T.Yamamura, M.Kronenberg, D.H.Raulet, K.Kinoshita, H.Yagita, M.J.Smyth, K.Okumura
- Journal Title
  
  Blood 106
  
  Pages: 184-192
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390120
[Journal Article] Blockade of B7-H1 on macrophages suppresses CD4+ T cell proliferation by augmenting IFN-gamma-induced nitric oxide production.2005
- Author(s)
  Yamazaki, T., H.Akiba, A.Koyanagi, M.Azuma, H.Yagita, K.Okumura
- Journal Title
  
  J Immunol 175
  
  Pages: 1586-1592
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390120
[Journal Article] Critical contribution of CD8O and CD86 to induction of anterior chamber-associated immune deviation.2005
- Author(s)
  Tsukahara, R., M.Takeuchi, H.Akiba, T.Kezuka, K.Takeda, Y.Usui, M.Usui, H.Yagita, K.Okumura
- Journal Title
  
  Int Immunol 17
  
  Pages: 523-530
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390120
[Journal Article] Clinical significance of programmed death-1 ligand-1 and programmed death-1 ligand-2 expression in human esophageal cancer.2005
- Author(s)
  Ohigashi Y, Sho M, Yamada Y, Tsurui Y, Hamada K, Ikeda N, Mizuno T, Yoriki R, Kashizuka H, Yane K, Tsushima F, Otsuki N, Yagita H, Azuma M, Nakajima Y
- Journal Title
  
  Clin Cancer Res 11
  
  Pages: 2947-2953
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016071
[Journal Article] IFN-□-mediated negative feedback regulation of NKT cell function by CD94/NKG2.2005
- Author(s)
  Ota T, Takeda K, Akiba H, Hayakawa Y, Ogasawara K, Ikarashi Y, Miyake S, Wakasugi H, Yamamura T, Kronenberg M, Raulet DH, Kinoshita K, Yagita H, Smyth MJ, Okumura K
- Journal Title
  
  Blood 106
  
  Pages: 184-192
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016071
[Journal Article] 2005.TWEAK mediates anti-tumor effect of tumor-infiltrating macrophage.2005
- Author(s)
  Kaduka, Y., K.Takeda, M.Nakayama, K.Kinoshita, H.Yagita, K.Okumura
- Journal Title
  
  Biochem Biophys Res Commun 331
  
  Pages: 384-390
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390120
[Journal Article] Amelioration of acute graft-versus-host disease by NKG2A engagement on donor T cells.2005
- Author(s)
  Kawamura, H., H.Yagita, T.Nisizawa, N.Izumi, C.Miyaji, R.E.Vance, D.H.Raulet, K.Okumura, T.Abo
- Journal Title
  
  Eur J Immunol 35
  
  Pages: 2358-2366
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390120
[Journal Article] ICOS costimulates invariant NKT cell activation.2005
- Author(s)
  Kaneda, H., K.Takeda, T.Ota, Y.Kaduka, H.Akiba, Y.Ikarashi, H.Wakasugi, M.Kronenberg, K.Kinoshita, H.Yagita, K.Okumura
- Journal Title
  
  Biochem Biophys Res Commun 327
  
  Pages: 201-207
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390120
[Journal Article] Sequential activation of NKT cells and NK cells provides effective innate immunotherapy of cancer.2005
- Author(s)
  Smyth MJ, Wallace ME, Nutt SL, Yagita H, Godfrey DI, Hayakawa Y
- Journal Title
  
  J Exp Med 201
  
  Pages: 1973-1985
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016071
[Journal Article] TRAIL identifies immature natural killer cells in newborn mice and adult mouse liver.2005
- Author(s)
  Takeda, K., E.Cretney, Y.Hayakawa, T.Ota, H.Akiba, K.Ogasawara, H.Yagita, K.Kinoshita, K.Okumura, M.J.Smyth
- Journal Title
  
  Blood 105
  
  Pages: 2082-2089
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390120
[Journal Article] Tumor necrosis factor alpha (TNFalpha) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNFalpha.2005
- Author(s)
  Xue, X., J.H.Piao, A.Nakajima, S.Sakon-Komazawa, Y.Kojima, K.Mori, H.Yagita, K.Okumura, H.Harding, H.Nakano
- Journal Title
  
  J Biol Chem 280
  
  Pages: 33917-33925
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390120
[Journal Article] ICOS costimulates invariant NKT cell activation.2005
- Author(s)
  Kaneda H, Takeda K, Ota T, Kaduka Y, Akiba H, Ikarashi Y, Wakasugi H, Kronenberg M, Kinoshita K, Yagita H, Okumura K
- Journal Title
  
  Biochem Biophys Res Commun 327
  
  Pages: 201-207
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016071
[Journal Article] Renal allograft rejection is prevented by adoptive transfer of anergic T cells in nonhuman primates.2005
- Author(s)
  Bashuda, H., M.Kimikawa, K.Seino, Y.Kato, F.Ono, A.Shimizu, H.Yagita, S.Teraoka, K.Okumura
- Journal Title
  
  J Clin Invest 115
  
  Pages: 1896-1902
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390120
[Journal Article] Immune responses against a single CD8+-T-cell epitope induced by virus vector vaccination can successfully control Trypanosoma cruzi infection.2005
- Author(s)
  Miyahira, Y., Y.Takashima, S.Kobayashi, Y.Matsumoto, T.Takeuchi, M.Ohyanagi-Hara, A.Yoshida, A.Ohwada, H.Akiba, H.Yagita, K.Okumura, H.Ogawa
- Journal Title
  
  Infect Immun 73
  
  Pages: 7356-7365
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390120
[Journal Article] 2005.Regulation of murine chronic colitis by CD4+CD25-programmed death-1+ T cells.2005
- Author(s)
  Totsuka, T., T.Kanai, S.Makita, R.Fujii, Y.Nemoto, S.Oshima, R.Okamoto, A.Koyanagi, H.Akiba, K.Okumura, H.Yagita, M.Watanabe
- Journal Title
  
  Eur J Immunol 35
  
  Pages: 1773-1785
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390120
[Journal Article] Induction of CD70 on dendritic cells through CD40 or TLR stimulation contributes to the development of CD8+ T cell responses in the absence of CD4+ T cells.2005
- Author(s)
  Bullock TNJ, Yagita H
- Journal Title
  
  J Immunol 174
  
  Pages: 710-717
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016071
[Journal Article] The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo.2005
- Author(s)
  Akiba, H., K.Takeda, Y.Kojima, Y.Usui, N.Harada, T.Yamazaki, J.Ma, K.Tezuka, H.Yagita, K.Okumura
- Journal Title
  
  J Immunol 175
  
  Pages: 2340-2348
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390120
[Journal Article] Induction of RANTES by TWEAK/Fn14 interaction in human keratinocytes.2004
- Author(s)
  Jin, L., A.Nakao, M.Nakayama, N.Yamaguchi, Y.Kojima, N.Nakano, R.Tsuboi, K.Okumura, H.Yagita, H.Ogawa
- Journal Title
  
  J Invest Dermatol 122
  
  Pages: 1175-1179
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390120
[Journal Article] TRAIL and its receptors as targets for cancer therapy.2004
- Author(s)
  Yagita, H. et al.
- Journal Title
  
  Cancer Sci 95
  
  Pages: 777-783
- NAID
  10014170265
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390120
[Journal Article] TRAIL and its receptors as targets for cancer therapy.2004
- Author(s)
  Yagita, H.
- Journal Title
  
  Cancer Sci. 95
  
  Pages: 777-783
- NAID
  10014170265
- Data Source
  KAKENHI-PROJECT-13214096
[Journal Article] Genome wide analysis of TNF-inducible genes reveals that antioxidant enzymes are induced by TNF and responsible for elimination of ROS.2004
- Author(s)
  Sasazuki, T., T.Okazaki, K.Tada, S.Sakon-Komazawa, M.Katano, M.Tanaka, H.Yagita, K.Okumura, N.Tominaga, Y.Hayashizaki, Y.Okazaki, H.Nakano
- Journal Title
  
  Mol Immunol 41
  
  Pages: 547-551
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390120
[Journal Article] TRAIL and its receptors as targets for cancer therapy.2004
- Author(s)
  Yagita, H., K.Takeda, Y.Hayakawa, M.J.Smyth, K.Okumura
- Journal Title
  
  Cancer Sci 95
  
  Pages: 777-783
- NAID
  10014170265
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390120
[Journal Article] Induction of tumor-specific T cell immunity by anti-DR5 antibody therapy.2004
- Author(s)
  Takeda, K., N.Yamaguchi, H.Akiba, Y.Kojima, Y.Hayakawa, J.E.Tanner, T.J.Sayers, N.Seki, K.Okumura, H.Yagita, M.J.Smyth
- Journal Title
  
  J Exp Med 199
  
  Pages: 437-448
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390120
[Journal Article] TWEAK/Fn14 interaction stimulates human bronchial epithelial cells to produce IL-8 and GM-CSF.2004
- Author(s)
  Xu, H., A.Okamoto, J.Ichikawa, T.Ando, K.Tasaka, K.Masuyama, H.Ogawa, H.Yagita, K.Okumura, A.Nakao
- Journal Title
  
  Biochem Biophys Res Commun 318
  
  Pages: 422-427
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390120
[Journal Article] Sensitization of human glioblastomas to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) by NF-kappaB inhibitors.2004
- Author(s)
  Kasuga, C., T.Ebata, N.Kayagaki, H.Yagita, M.Hishii, H.Arai, K.Sato, K.Okumura
- Journal Title
  
  Cancer Sci 95
  
  Pages: 840-844
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390120
[Journal Article] Ameliorating effect of anti-ICOS monoclonal antibody in a murine model of chronic colitis.2003
- Author(s)
  Totsuka T, Kanai T^#, Iiyama R, Uraushihara K, Yamazaki M, Okamoto R, Hibi T, Tezuka K, Azuma M, Akiba H, Yagita H, Okumura K, Watanabe M.
- Journal Title
  
  Gastroenterology 124
  
  Pages: 410-421
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590627
[Journal Article] Preventive effects of chronic colitis in CD4^+CD45RB^+ T cell-transferred SCID mice by anti-FasL mAb administration.2003
- Author(s)
  Dan N, Kanai T, Totsuka T, Iiyama R, Yamazaki M, Sawada T, Miyata T, Yagita H, Okumura K, Watanabe M.
- Journal Title
  
  Am J Physiol GI & Liver 285
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590627
[Journal Article] The role of inducible co-stimulator (ICOS)/B7 related protein-1 (B7RP-1) interaction in the functional development of Peyer's patches.2003
- Author(s)
  Iiyama R, Kanai T^#, Uraushihara K, Totsuka T, Nakamura T, Miyata T, Yagita H, Kushi A, Suzuki K, Tezuka K, Watanabe M.
- Journal Title
  
  Immunol Letters 88
  
  Pages: 63-70
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590627
[Journal Article] Blockade of B7-H1 suppresses the development of chronic intestinal inflammation.2003
- Author(s)
  Kanai T, Totsuka T, Uraushihara K, Makita S, Nakamura T, Koganei K, Fukushima T, Akiba H, Yagita H, Okumura K, Machida U, Iwai H, Azuma M, Chen L, Watanabe M.
- Journal Title
  
  J Immunol 171
  
  Pages: 4156-4163
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590627
[Journal Article] Preventive and therapeutic effects of chronic colitis in CD4^+CD45RB^+ T cell-transferred SCID mice by anti-OX40L mAb administration.2003
- Author(s)
  Totsuka T, Kanai T^#, Uraushihara K, Iiyama R, Akiba H, Yagita H, Okumura K, Watanabe M.
- Journal Title
  
  Am J Physiol GI & Liver 284
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590627
[Journal Article] Regulation of murine chronic colitis by CD4^+CD25^-Programed Death-1^+ T cells.
- Author(s)
  Totsuka T, Kanai T, Makita S, Fujii R, Nemoto Y, Oshima S, Okamoto R, Koyanagi A, Akiba H, Okumura K, Yagita H, Watanabe M.
- Journal Title
  
  Eur J Immunol (in the press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590627
[Journal Article] 2006. The role of the ICOS/B7RP-1 T cell costimulatory pathway in murine experimental autoimmune uveoretinitis
- Author(s)
  Usui, Y., H., Akiba, M., Takeuchi, T., Kezuka, A., Takeuchi, T., Hattori, Y., Okunuki, T., Yamazaki, H., Yagita, M., Usui, K., Okumura
- Journal Title
  
  European journal of immunology 36
  
  Pages: 3071-3081
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390292
[Journal Article] Ameliorating effect of saporin-conjugated anti-CD11b monoclonal antibody in a murine T-cell-mediated chronic colitis.
- Author(s)
  Kanai T^#, Uraushihara K, Totsuka T, Nemoto Y, Fujii R, kawamura T, Makita S, Yagita H, Okumura K, Watanabe M.
- Journal Title
  
  J Gastrornt Hepatol (in the press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590627
[Presentation] Role of B7-H3/TLT-2 pathway in immune privilege of corneal allografts2017
- Author(s)
  Taniguchi, H Hase, H Akiba, H Yagita, M Azuma
- Organizer
  ARVO 2017 (The Association for Research in Vision and Ophthalmology)
- Place of Presentation
  Baltimore, USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462700
[Presentation] Augmented anti-cancer therapeutic effect using antibodies to multiple target molecules with immune checkpoint blockade.2016
- Author(s)
  Terashima K, Tanaka M, Imaida T, Ueda S, Yagita H, Masuko T
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-26290059
[Presentation] Expression of ICOS and Foxp3 on T cells infiltrating in corneal allografts2016
- Author(s)
  H Taniguchi, T Kunishige, H Akiba, H Yagita, R Abe, J Hori
- Organizer
  ARVO 2016 (The Association for Research in Vision and Ophthalmology)
- Place of Presentation
  Seattle, WA, USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462700
[Presentation] Molecular mechanisms of immune privilege of the cornea - as a potential of Immune Checkpoint therapy2016
- Author(s)
  J Hori, H Taniguchi, M Azuma, R Abe, H Yagita
- Organizer
  Tokyo Ocular immunology meeting
- Place of Presentation
  東京
- Year and Date
  2016-02-26
- Invited
- Data Source
  KAKENHI-PROJECT-26462700
[Presentation] Non-apoptotic, non-necrotic novel cell death (anapocosis) of lymphoma cells induced by therapeutic mAbs.2016
- Author(s)
  Matsuoka S, Ishii Y, Yagita H
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-26290059
[Presentation] Antigen delivery to tumoral macrophages leads to eradication of tumor resistant to immune checkpoint inhibitors.2016
- Author(s)
  Muraoka D, Seo N, Harada N, Fujii K, Komuro M, Imoto S, Yamaguchi R, Miyano S, Yagita H, Akiyoshi K, Shiku H
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-26290059
[Presentation] Anti-pan MHC mAb induce cell death for ex-vivo lymphoma cells by anapocosis.2016
- Author(s)
  Matsuoka S, Ishii Y, Takamatsu H, Hasegawa H, Mizutani N, Yagita H, Hino O
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-26290059
[Presentation] Expression of ICOS and Foxp3 on T cells infiltrating in corneal allografts2016
- Author(s)
  H Taniguchi, T Kunishige, H Akiba, H Yagita, R Abe, J Hori
- Organizer
  ARVO
- Place of Presentation
  Seattle, USA
- Year and Date
  2016-05-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462700
[Presentation] A combination of anti-angiogenic and anti-lymphangiogenic therapies augments effects of an antitumor immunotherapy.2016
- Author(s)
  Tsukita Y, Okazaki T, Yagita H, Ichinose M
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-26290059
[Presentation] Effect of regulation of immune checkpoint molecules on ADCC with NK cells.2015
- Author(s)
  Tanaka M, Terashima K, Imaida T, Abe S, Ueda S, Yagi H, Yagita H, Masuko T
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26290059
[Presentation] The immunogenicity of antigen decides the tumoral inflammation and therapeutic efficacy of immune checkpoint blockades.2015
- Author(s)
  Muraoka D, Seo N, Hayashi T, Harada N, Komura M, Yamaguchi R, Imoto S, Miyano S, Yagita H, Shiku H
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26290059
[Presentation] Cytolytic anti-pan HLA-class II mAb and anti-pan MHC class I mAb directly induces lymphoma cell death via large pore formation.2015
- Author(s)
  Matsuoka S, Yagita H, Ishii Y
- Organizer
  第44回日本免疫学会学術集会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-26290059
[Presentation] VISTA and CTLA-4 combination blockade enhances multifunctionality of tumor infiltrating CD8+ T cells.2015
- Author(s)
  Kondo Y, Ohno T, Bhingare AC, Yagita H, Harada K, Azuma M
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26290059
[Presentation] Combination immune checkpoint blockade with VISTA and CTLA-4 enhances anti-tumor responses.2015
- Author(s)
  Kondo Y, Ohno T, Bhingare AC, Yagita H, Harada K, Azuma M
- Organizer
  第44回日本免疫学会学術集会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-26290059
[Presentation] Corneal Cell-Mediated Immune Regulation and Immune Privilege2015
- Author(s)
  J Hori, H Taniguchi, M Azuma, R Abe, H Yagita
- Organizer
  Harvard Medical School Cornea Center of Excellence international Workshop
- Place of Presentation
  Boston, MA, USA
- Year and Date
  2015-10-15
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462700
[Presentation] 角膜移植後の免疫寛容における Tim-3 / Gal-9 経路の抑制的役割2012
- Author(s)
  榛村真智子、堀　純子、王明聡、谷口ヒロ子、高橋浩、梯彰弘、秋葉久弥、八木田秀雄
- Organizer
  第 46 回日本眼炎症学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23592619
[Presentation] アジュバントとしての免疫賦活化抗体2012
- Author(s)
  八木田秀雄
- Organizer
  日本がん免疫学会
- Place of Presentation
  北海道大学学術交流会館
- Invited
- Data Source
  KAKENHI-PROJECT-22240089
[Presentation] 角膜移植後の免疫寛容におけるTim-3 / Gal-9経路の抑制的役割2012
- Author(s)
  榛村真智子、堀純子、王明聡、谷口ヒロ子、高橋浩、梯彰弘、秋葉久弥、八木田秀雄
- Organizer
  第46回日本眼炎症学会
- Place of Presentation
  横浜
- Year and Date
  2012-07-15
- Data Source
  KAKENHI-PROJECT-23592619
[Presentation] 角膜移植後の眼局所におけるTLT-2の発現と機能2011
- Author(s)
  谷口ヒロ子、堀純子、秋葉久弥、八木田秀雄、長谷英徳、東みゆき
- Organizer
  第115回日本眼科学会
- Place of Presentation
  東京
- Year and Date
  2011-05-12
- Data Source
  KAKENHI-PROJECT-23592619
[Presentation] Correlation between proportion of splenic Foxp3+CD8+T regulatory cells and corneal allograft survival2011
- Author(s)
  K. Wakayama, H. Taniguchi, H. Akiba, H. Yagita, M. Azuma, J. Hori
- Organizer
  ARVO
- Place of Presentation
  USA
- Year and Date
  2011-05-01
- Data Source
  KAKENHI-PROJECT-23592619
[Presentation] Correlation between proportion of splenic Foxp3+CD8+T regulatory cells and corneal allograft survival.2011
- Author(s)
  K. Wakayama, H. Taniguchi, H. Akiba, H. Yagita, M. Azuma, J. Hori.
- Organizer
  Association for Research in Vision and Ophthalmology(ARVO)
- Place of Presentation
  フロリダ
- Data Source
  KAKENHI-PROJECT-23592619
[Presentation] 角膜アログラフトの生着における脾臓内Foxp3+CD8+制御性T細胞の関与2011
- Author(s)
  谷口ヒロ子、堀純子、秋葉久弥、八木田秀雄、東みゆき
- Organizer
  第45回日本眼炎症学会
- Place of Presentation
  京都
- Year and Date
  2011-07-09
- Data Source
  KAKENHI-PROJECT-23592619
[Presentation] 角膜移植の免疫特権におけるTim-3/Gal-9経路の役割2011
- Author(s)
  榛村真智子、堀純子、王明聡、谷口ヒロ子、秋葉久弥、八木田秀雄
- Organizer
  第16回Tokyo Ocular Immunology Meeting
- Place of Presentation
  東京
- Year and Date
  2011-09-30
- Data Source
  KAKENHI-PROJECT-23592619
[Presentation] Expression of TLT-2 in corneal tissue and macrophages after corneal transplantation and association with immune privilege of corneal allografts2011
- Author(s)
  H. Taniguchi, H. Sase, H. Akiba, H. Yagita, M. Azuma, J. Hori
- Organizer
  ARVO
- Place of Presentation
  USA
- Year and Date
  2011-05-04
- Data Source
  KAKENHI-PROJECT-23592619
[Presentation] 腫瘍免疫の基礎理論2010
- Author(s)
  八木田秀雄
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-22240089
[Presentation] 抗体を用いた抗腫瘍免疫の誘導と増強2008
- Author(s)
  八木田秀雄
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-17016071
[Presentation]2008
- Author(s)
  Takeda K, Kojima Y, Yagita H, Smyth MJ, Okumura K
- Organizer
  第38回日本免疫学会
- Place of Presentation
  京都国際会議場
- Year and Date
  2008-12-01
- Data Source
  KAKENHI-PROJECT-19590257
[Presentation]2008
- Author(s)
  Kojima Y, Takeda K, Yagita H, Smyth MJ, Okumura K
- Organizer
  第38回日本免疫学会
- Place of Presentation
  京都国際会議場
- Year and Date
  2008-12-01
- Data Source
  KAKENHI-PROJECT-19590257
[Presentation] Commensal bacteria regulate thymic Aire expression
- Author(s)
  Nakajima A, Negishi N, Tsurui H, Nanno M, Yagita H, Okumura K, Miyake S, Habu S
- Organizer
  第43回日本免疫学会学術集会
- Place of Presentation
  京都国際会議場
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-26290059
[Presentation] Anti-tumor effects of mAb against a new immune-checkpoint molecule VISTA
- Author(s)
  Kondo Y, Ohno T, Zhang C, Yagita H, Harada K, Azuma M
- Organizer
  第73回日本癌学会学術集会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26290059
[Presentation] Therapeutic anti-pan HLA class II mAb induces the death of leukemia/lymphoma cells via large pore formation
- Author(s)
  Matsuoka S, Mizutani N, Yagita H, Hino O
- Organizer
  第73回日本癌学会学術集会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26290059
[Presentation] TNFR2 signaling in the epithelia may be involved in the development of colitis-associated tumor
- Author(s)
  Watabe T, Nagaishi T, Suzuki M, Yamazaki M, Onizawa M, Jose N, Tokai A, Hosoya A, Totsuka M, Yagita H, Watanabe M
- Organizer
  第43回日本免疫学会学術集会
- Place of Presentation
  京都国際会議場
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-26290059
[Presentation] Anti-pan MHC class I and class II mAbs directly induce lymphoma cell death via large pore formation
- Author(s)
  Matsuoka S, Yagita H, Ishii Y
- Organizer
  第43回日本免疫学会学術集会
- Place of Presentation
  京都国際会議場
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-26290059
[Presentation] Anti-tumor effects of mAb against a new immune-checkpoint molecule VISTA/PD-1H
- Author(s)
  Kondo Y, Ohno T, Zhang C, Yagita H, Harada K, Azuma M
- Organizer
  第43回日本免疫学会学術集会
- Place of Presentation
  京都国際会議場
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-26290059
[Presentation] The suppression of naive T cells requires cell-to-cell contact by TSST-1-induced anergic T cellls
- Author(s)
  Negishi N, Sato T, Kametani Y, Hori S, Yagita H, Okumura K, Habu S
- Organizer
  第43回日本免疫学会学術集会
- Place of Presentation
  京都国際会議場
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-26290059
[Presentation] Combination immunotherapy with 4-1BB mAb and PD-1 mAb enhances antitumor efficacy in mouse subcutaneous model
- Author(s)
  Shindo Y, Yoshimura K, Kuramasu A, Ito H, Oga A, Maeda N, Yoshino S, Hazama S, Tamada K, Yagita H, Oka M
- Organizer
  第73回日本癌学会学術集会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26290059

1. OKUMURA Ko (50009700)

# of Collaborated Projects: 28 results

# of Collaborated Products: 42 results
2. AZUMA Miyuki (90255654)

# of Collaborated Projects: 7 results

# of Collaborated Products: 9 results
3. WATANABE Mamoru (10175127)

# of Collaborated Projects: 5 results

# of Collaborated Products: 7 results
4. NAKANO Hiroyasu (70276476)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
5. HIRANO Takao (10165186)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
6. KATO Kazunori (60233780)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
7. KANAI Takanori (40245478)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
8. TAKEDA Kazuyoshi (80272821)

# of Collaborated Projects: 3 results

# of Collaborated Products: 15 results
9. MIYAJIMA Hiroaki (80209907)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
10. 橋本嘉幸 (90072412)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
11. 西村孝司 (30143001)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
12. 湊長博 (40137716)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
13. 西川伸一 (60127115)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
14. 菊谷仁 (80161412)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
15. 垣生園子 (30051618)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
16. 高橋利忠 (00124529)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
17. 遠藤啓吾 (10115800)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
18. 益子高 (30157200)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
19. 今井浩三 (60117603)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
20. 屋部登志雄 (50239836)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
21. OBATA Tetsuji (10205445)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
22. HORI Junko (60251279)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
23. TANIGUCHI Hiroko (00535445)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
24. NAKAUCHI Hiromitsu (40175485)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
25. KUMAGAI Yoshihiro (80175314)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
26. RA Chisei (60230851)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
27. OSHIMI Kazuo (40089991)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
28. EBATA Tomohiko (30343487)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
29. AKIBA Hisaya (60338316)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
30. 栗林景容 (10064578)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
31. 中西守 (90090472)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
32. 宮崎純一 (10200156)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
33. 橋田充 (20135594)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
34. 榧垣伸彦 (80317403)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
35. 中村哲也 (70265809)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
36. KOJIMA Yuko (60231312)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
37. KITAHARA Yuki (30360176)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. HASHIMOTO Hiroshi (60053120)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. KOBAYASHI Sigeko (40186739)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. TAKASAKI Yoshinari (80154772)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
41. TOKANO Yoshiaki (40217469)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
42. YAMADA Masato (90311977)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
43. TAMURA Naoto (20227284)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
44. FUKAZAWA Toru (30301500)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
45. ITOH Kyogo (50125499)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
46. HIBI Toshifumi (50129623)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
47. NAKAYAMA Masafumi (20453582)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
48. Okazaki Tatsuma (40396479)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
49. Abe Ryo (20159453)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
50. Mochizuki Kazuhiro (30448633)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
51. Ohto Hitoshi (20150279)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
52. Fujimori Keiya (80285030)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
53. 大沢利昭 (40012603)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
54. 木梨達雄 (30202039)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
55. 山口祐司 (00220286)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
56. 古川鋼一 (80211530)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
57. 豊島聰 (40092283)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
58. 緒方正人 (60224094)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
59. 仲野徹 (00172370)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
60. 武内ゆみ子 (90179622)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
61. 谷憲三朗 (00183864)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
62. 小澤敬也 (30137707)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
63. 浅野茂隆 (50134614)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
64. 新田泰三 (80172724)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
65. 佐藤潔 (10112707)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
66. 小柳津直樹 (00282773)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
67. 佐々木英忠 (20004731)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
68. 土屋輝一郎 (40376786)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
69. 中村哲也 (30189047)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
70. 國重智之 (60516045)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
71. 佐野秀樹 (20448632)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
72. 小林正悟 (30566849)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
73. 菊田敦 (40224894)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
74. 橋本浩一 (50322342)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
75. HARADA Kenichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
76. Kobayashi Makoto

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
77. Tamai Tokiwa

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
78. Nihei Mayumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
79. Tsukita Yoko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
80. Komatsu Riyo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
81. 中田元巳

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
82. 吉野公一郎

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
83. ZOLTAN Ovary

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
84. OVARY Zoltan

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
85. Zhang Yi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
86. ISHIFUNE Chieko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
87. FUJII Shinーichiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
88. 前川洋一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
89. 安友康二

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
90. 葛島清隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
91. 山崎哲

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
92. 清水佳奈子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
93. 加藤聖子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
94. 十川久美子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
95. 徳永万喜洋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
96. 大場雄介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
97. 地主将久

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
98. 吉山裕規

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
99. 木下一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
100. 瀬谷司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
101. 松本美佐子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
102. 山崎小百合

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
103. 中尾篤人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
104. 増谷弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
105. 荒瀬尚

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
106. JIN HUI

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
107. 加藤昌志

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
108. 冨原圭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
109. 砂村眞琴

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
110. 症雅之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
111. 田原秀晃

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
112. 岩倉洋一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
113. 入村達郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
114. 早川芳弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
115. 岡田太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
116. 善本隆之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
117. 済木育夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
118. 安倍能之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
119. 大野建州

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
120. 千葉滋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
121. 加藤貴康

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YAGITA Hideo 八木田 秀雄

Research Projects

Research Products

Co-Researchers

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of immuno-stimulatory antibody therapy against cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of immuno-stimulatory antibody therapy against cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanism of cancer immunosurveillance and its application to cancer therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Physiological and pathological functions of TNF/TNF receptor family molecules.Principal Investigator

Principal Investigator

Project Period (FY)

YAGITA Hideo 八木田秀雄