Tsuchiya Kiichiro 土屋輝一郎

… Alternative Names

Researcher Number	40376786
Other IDs
Affiliation (Current)	2020: 東京医科歯科大学, 医学部附属病院, 准教授
Affiliation (based on the past Project Information) *help	2015 – 2020: 東京医科歯科大学, 医学部附属病院, 准教授 2015: 東京医科歯科大学, 医学部附属病院消化器内科, 准教授 2015: 東京医科歯科大学, 大学院医歯学総合研究科, 准教授 2013 – 2014: 東京医科歯科大学, 医歯(薬)学総合研究科, 寄附講座准教授 2012: 東京医科歯科大学, 医歯(薬)学総合研究科, 寄附講座講師 … More
Review Section/Research Field	Principal Investigator Gastroenterology / Biological Sciences / Basic Section 53010:Gastroenterology-related / Medium-sized Section 53:Organ-based internal medicine and related fields Except Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related / Biological Sciences / Medium-sized Section 53:Organ-based internal medicine and related fields
Keywords	Principal Investigator Atoh1 / Hath1 / 癌幹細胞 / 小腸 / 炎症性腸疾患 / シグナルスパイラル / 分化制御 / 標的遺伝子 / パネート細胞 / 抗菌物質 … More Except Principal Investigator 炎症性腸疾患 / Notchシグナル / Notch / Atoh1 / クローン病 / Wntシグナル / シグナル伝達 / Wnt / Hath1 / IL-7 / 再生医学 / トランスレーショナルリサーチ / 細胞内シグナル伝達 / マッピング生検 / バルーン内視鏡 / 腸管分化 / 転写因子 / iPS細胞 / 再生医療 / transdifferentiation / 杯細胞分化 / Interferon Regulatory Factor (IRF) / 免疫学 / 生体分子 / IL-7レセプター / Interferon Regulatory Factor(IRF) / 消化管粘膜免疫制御 / 免疫制御療法 / 腸管再生 / CEACAM1 / リンパ球 / 粘膜免疫 / サイトカイン / ダブルバルーン内視鏡 / DBE / 小腸生検 / 小腸培養 / 杯細胞 / 小腸内視鏡 / 生検検体 / 腸管上皮 / オルガノイド / ニッチ / 幹細胞ニッチ / 潜在的炎症 / 小腸がん / 網羅的遺伝子解析 / 腸内環境 / 共培養 / 幹細胞機能評価 / 疑似モデル構築 / 全身制御 / 発生・分化 / ユビキチン-プロテアソーム / Hath-1 / Differentiation / Regenerative medicine / Translational research / Signal transduction / 慢性大腸炎 / 大腸上皮再生 / 幹細胞 / Chronic colitis / Regeneration / Stem Cell / HD6 / 抗菌物質 / 粘膜バリア能 / 粘膜防御 / ナノネット / 小腸オルガノイド / 再燃予測 / 病態解明 / 炎症応答評価 / 分子マーカー / 臓器間制御 / ヒトオルガノイド / 複合臓器体外モデル / 胆管癌 / 胆汁 / 発癌機序 / 好発部位 / 炎症修飾 / 病変部由来オルガノイド / ヒト体外IBDモデル / 粘膜治癒 Less

ヒトクローン病モデル構築による粘膜治癒機構の解明Ongoing
- Principal Investigator
  
  大塚和朗
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokyo Medical and Dental University
ヒト体外複合臓器モデルによる生体維持機構解析Ongoing
- Principal Investigator
  
  渡辺守
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Tokyo Medical and Dental University
ヒトiPS細胞由来胆管細胞培養系を用いた胆管癌における新規発癌機序の解明Ongoing
- Principal Investigator
  
  小林正典
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokyo Medical and Dental University
腸上皮化生を主眼とした消化器がんのスキルス化機構に関する研究Principal InvestigatorOngoing
- Principal Investigator
  
  土屋輝一郎
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokyo Medical and Dental University
炎症性腸疾患病変部に共通する特異的本態の解明Ongoing
- Principal Investigator
  
  竹中健人
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokyo Medical and Dental University
位置運命決定因子におけるヒト成体器官機能制御の解明Principal InvestigatorOngoing
- Principal Investigator
  
  土屋輝一郎
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Tokyo Medical and Dental University
クローン病再燃予測システムの開発Ongoing
- Principal Investigator
  
  大塚和朗
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
ナノネット粘膜防御によるクローン病新規治療開発
- Principal Investigator
  
  荒木昭博
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
Single cell imaging in human intestinal stem cellPrincipal Investigator
- Principal Investigator
  
  Tsuchiya Kiichiro
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
Inflammation related carcinogenesis by spiral cell transformation using in vitro chronic colitis modelPrincipal Investigator
- Principal Investigator
  
  TSUCHIYA Kiichiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
The elucidation of homeostasis regulated by intestinal epithelial stem cells
- Principal Investigator
  
  Watanabe Mamoru
- Project Period (FY)
  2014 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
腸管上皮細胞における自然免疫応答スパイラル機構解析Principal Investigator
- Principal Investigator
  
  土屋輝一郎
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
ヒト大腸上皮培養による大腸癌幹細胞の分化破綻機構解析Principal Investigator
- Principal Investigator
  
  土屋輝一郎
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
Development of colitic mucosa repair therapy by the induction of regeneration-specific stem cell niche formation
- Principal Investigator
  
  Okamoto Ryuichi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
Analysis of the pathogenesis in CD using mapping biopsy from entire small intestine
- Principal Investigator
  
  Araki Akihiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
Comprehensive gene analysis of small intestinal cancer tumor
- Principal Investigator
  
  Ohtsuka Kazuo
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
The analysis for the regulation of IEC differentiation by the switching mechanism of GSK3Principal Investigator
- Principal Investigator
  
  TSUCHIYA Kiichiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
ヒト大腸上皮培養による大腸癌幹細胞の分化破綻機構解析Principal Investigator
- Principal Investigator
  
  土屋輝一郎
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
The elucidation of functional regulation and pathogenesis in the entire human small intestine.
- Principal Investigator
  
  ARAKI Akihiro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
The regulation of Paneth cells gene expression by Hath1Principal Investigator
- Principal Investigator
  
  TSUCHIYA Kiichirou
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
CEACAM1 regulates the cytokine network in intestinal mucosa
- Principal Investigator
  
  NAGAISHI Takashi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
Regeneration of intestinal mucosa and molecular mechanism of the failure of intestinal epithelial cells under intestinal inflammation.
- Principal Investigator
  
  WATANABE Mamoru
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
The analysis of the regulation in intestinal differentiation by thecomprehensive search of Hath1 target genesPrincipal Investigator
- Principal Investigator
  
  TSUCHIYA Kiichirou
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
腸管粘膜局所IL-7ネットワーク制御応用による新規免疾統御療法開発
- Principal Investigator
  
  渡辺守
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
Identification of the crosstalk between Notch signaling and Wnt signaling in the differentiation of the intestinal epithelial cells.
- Principal Investigator
  
  WATANABE Mamoru
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
Clarification of the interaction between the differentiation and immune regulation of goblet cells by Math1.Principal Investigator
- Principal Investigator
  
  TSUCHIYA Kiichiro
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
Identification of the Notch signal in intestinal epithelial cells and the failure of the intestinal differentiation in chronic colitis.
- Principal Investigator
  
  OKADA Eriko
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
粘膜免疫の特殊性を応用した腸管免疫統御療法の開発
- Principal Investigator
  
  WATANABE Mamoru
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University

[Journal Article] A subset of diffuse-type gastric cancer is susceptible to mTOR inhibitors and checkpoint inhibitors2019
- Author(s)
  Fukamachi H., Kim S., K., Koh J., Lee H. S., Sasaki Y., Yamashita K., Nishikawaji T., Shimada S., Akiyama Y., Byeon S. J., Bae D. H., Okuno K., Nakagawa M., Tanioka T., Inokuchi M., Kawachi H., Tsuchiya K., Kojima K., Tokino T., Eishi Y., Kim Y. S., Kim W. H., Yuasa Y., Tanaka S.
- Journal Title
  
  J Exp Clin Cancer Res
  
  Volume: 38 Pages: 127-127
- DOI
  10.1186/s13046-019-1121-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-16K08647, KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-18K19535, KAKENHI-PROJECT-18K19575, KAKENHI-PROJECT-16H02670, KAKENHI-PROJECT-18H02791, KAKENHI-PROJECT-15K06832, KAKENHI-PROJECT-16H06279
[Journal Article] Establishment of a system to evaluate the therapeutic effect and the dynamics of an investigational drug on ulcerative colitis using human colonic organoids2019
- Author(s)
  Nishimura R, Shirasaki T, Tsuchiya K, Miyake Y, Watanabe Y, Hibiya S, Watanabe S, Nakamura T, Watanabe M
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: in press
- DOI
  10.1007/s00535-018-01540-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19535, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-18H02791, KAKENHI-PROJECT-17H06654, KAKENHI-PROJECT-17K19513, KAKENHI-PROJECT-17K15930
[Journal Article] TP53 mutation by CRISPR system enhances the malignant potential of colon cancer.2019
- Author(s)
  Watanabe S, Tsuchiya K, Nishimura R, Shirasaki T, Katsukura N, Hibiya S, Okamoto R, Nakamura T, Watanabe M
- Journal Title
  
  Mol Cancer Res.
  
  Volume: in press
- DOI
  10.1158/1541-7786.mcr-18-1195
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-17K19513
[Journal Article] Ubiquitin D is up-regulated by synergy of Notch signaling and TNF-α in the inflamed intestinal epithelia of IBD patients.2019
- Author(s)
  Kawamoto Ami、Nagata Sayaka、Anzai Sho、Takahashi Junichi、Kawai Mao、Hama Minami、Nogawa Daichi、Yamamoto Kouhei、Kuno Reiko、Suzuki Kohei、Shimizu Hiromichi、Hiraguri Yui、Yui Shiro、Oshima Shigeru、Tsuchiya Kiichiro、Nakamura Tetsuya、Ohtsuka Kazuo、Kitagawa Masanobu、Okamoto Ryuichi、Watanabe Mamoru
- Journal Title
  
  Journal of Crohn and Colitis
  
  Volume: 13 Pages: 495-509
- DOI
  10.1093/ecco-jcc/jjy180
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09370, KAKENHI-PROJECT-18K07902, KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-17K19675, KAKENHI-PROJECT-18K19535, KAKENHI-PROJECT-18K15743, KAKENHI-PROJECT-18K15774, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-16H05284, KAKENHI-PROJECT-17H04024, KAKENHI-PROJECT-18H02791, KAKENHI-PROJECT-18H02867, KAKENHI-PROJECT-17K19513, KAKENHI-PROJECT-17K19674
[Journal Article] Contribution of ATOH1+ cells to the homeostasis, repair and tumorigenesis of the colonic epithelium.2018
- Author(s)
  Ishibashi Fumiaki、Shimizu Hiromichi、Nakata Toru、Fujii Satoru、Suzuki Kohei、Kawamoto Ami、Anzai Sho、Kuno Reiko、Nagata Sayaka、Ito Go、Murano Tatsuro、Mizutani Tomohiro、Oshima Shigeru、Tsuchiya Kiichiro、Nakamura Tetsuya、Watanabe Mamoru、Okamoto Ryuichi
- Journal Title
  
  Stem Cell Rep.
  
  Volume: 10 Pages: 27-42
- DOI
  10.1016/j.stemcr.2017.11.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19674, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H05284, KAKENHI-PROJECT-17K19675, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-17H04024, KAKENHI-PROJECT-17K19513
[Journal Article] Single cell analysis of Crohn’s disease patient-derived small intestinal organoids reveals disease activity-dependent modification of stem cell properties.2018
- Author(s)
  Suzuki Kohei、Murano Tatsuro、Shimizu Hiromichi、Ito Go、Nakata Toru、Fujii Satoru、Ishibashi Fumiaki、Kawamoto Ami、Anzai Sho、Kuno Reiko、Kuwabara Konomi、Takahashi Junichi、Tsuchiya Kiichiro、Nakamura Tetsuya、Ohtsuka Kazuo、Watanabe Mamoru、Okamoto Ryuichi
- Journal Title
  
  J Gastroenterol.
  
  Volume: 印刷中 Pages: 1035-1047
- DOI
  10.1007/s00535-018-1437-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H05284, KAKENHI-PROJECT-16K09302, KAKENHI-PROJECT-17K09370, KAKENHI-PROJECT-18K07902, KAKENHI-PROJECT-17K19675, KAKENHI-PROJECT-18K19535, KAKENHI-PROJECT-18K15743, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-17H04024, KAKENHI-PROJECT-18H02791, KAKENHI-PROJECT-18H02867, KAKENHI-PROJECT-17K19513, KAKENHI-PROJECT-17K19674
[Journal Article] Novel polyubiquitin imaging system, PolyUb-FC, reveals that K33-linked polyubiquitin is recruited by SQSTM1/p62.2018
- Author(s)
  Yoichi Nibe, Shigeru Oshima, Masanori Kobayashi, Chiaki Maeyashiki, Yu Matsuzawa, Kana Otsubo, Hiroki Matsuda, Emi Aonuma, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Shinichiro Nakada, Mamoru Watanabe
- Journal Title
  
  Autophagy
  
  Volume: 22 Pages: 347-358
- DOI
  10.1080/15548627.2017.1407889
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09372, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H05284, KAKENHI-PROJECT-16H05286, KAKENHI-PROJECT-16K15423, KAKENHI-PROJECT-17K19675, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-17H04024, KAKENHI-PROJECT-17K19513, KAKENHI-PROJECT-26241014
[Journal Article] Predictors of mucosal healing during induction therapy in patients with acute moderate-to-severe ulcerative colitis.2018
- Author(s)
  Motobayashi Maiko、Matsuoka Katsuyoshi、Takenaka Kento、Fujii Toshimitsu、Nagahori Masakazu、Ohtsuka Kazuo、Iwamoto Fumihiko、Tsuchiya Kiichiro、Negi Mariko、Eishi Yoshinobu、Watanabe Mamoru
- Journal Title
  
  Gastroenterol Hepatol.
  
  Volume: in press
- DOI
  10.1111/jgh.14565
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09370, KAKENHI-PROJECT-17K09372, KAKENHI-PROJECT-18K07902, KAKENHI-PROJECT-18K19535, KAKENHI-PROJECT-18H02791
[Journal Article] Data showing proliferation and differentiation of intestinal epithelial cells under targeted depletion of Notch ligands in mouse intestine.2017
- Author(s)
  Nakata T, Shimizu H, Nagata S, Ito G, Fujii S, Suzuki K, Kawamoto A, Ishibashi F, Kuno R, Anzai S, Murano T, Mizutani T, Oshima S, Tsuchiya K, Nakamura T, Hozumi K, Watanabe M, Okamoto R
- Journal Title
  
  Data in Brief
  
  Volume: 10 Pages: 551-556
- DOI
  10.1016/j.dib.2016.12.045
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H05284
[Journal Article] Regulation of intestinal homeostasis by the ulcerative colitis-associated gene RNF1862017
- Author(s)
  Fujimoto K, Kinoshita M, Tanaka H, Okuzaki D, Shimada Y, Kayama H, Okumura R, Furuta Y, Narazaki M, Tamura A, Hatakeyama S, Ikawa M, Tsuchiya K, Watanabe M, Kumanogoh A, Tsukita S, Takeda K
- Journal Title
  
  Mucosal Immunology
  
  Volume: 10 Pages: 446-445
- DOI
  10.1038/mi.2016.58
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H02511, KAKENHI-PROJECT-15H04690, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-15K15152, KAKENHI-ORGANIZER-25112001, KAKENHI-PLANNED-24113002
[Journal Article] Long-term Inflammation Transforms Intestinal Epithelial Cells of Colonic Organoids2017
- Author(s)
  Hibiya S, Tsuchiya K, Hayashi R, Horita N, Watanabe S, Shirasaki T, Nishimura R, Kimura N, Nishimura T, Gotoh N, Oshima S, Okamoto R, Nakamura T, Watanabe M
- Journal Title
  
  Journal of Crohn's and Colitis
  
  Volume: 61 Pages: 621-630
- DOI
  10.1093/ecco-jcc/jjw186
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H06770, KAKENHI-PROJECT-15K15287, KAKENHI-PROJECT-17K15930, KAKENHI-PROJECT-17H06654, KAKENHI-PROJECT-16K09302
[Journal Article] Indispensable role of Notch ligand-dependent signaling in the proliferation and stem cell niche maintenance of APC-deficient intestinal tumors.2017
- Author(s)
  Nakata T, Shimizu H, Nagata S, Ito G, Fujii S, Suzuki K, Kawamoto A, Ishibashi F, Kuno R, Anzai S, Murano T, Mizutani T, Oshima S, Tsuchiya K, Nakamura T, Hozumi K, Watanabe M, Okamoto R
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 482 Pages: 1296-1303
- DOI
  10.1016/j.bbrc.2016.12.031
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H05284
[Journal Article] Caudal type homeobox 2 expression induced by leukocytapheresis might be associated with mucosal healing in ulcerative colitis2017
- Author(s)
  Tsuchiya K, Hayashi R, Fukushima K, Hibiya S, Horita N, Negi M, Itoh E, Akashi T, Eishi Y, Motoya S, Takeuchi Y, Kunisaki R, Fukunaga K, Nakamura S, Yoshimura N, Takazoe M, Iizuka B, Suzuki Y, Nagahori M, Watanabe M
- Journal Title
  
  Journal of Gastroenterology and Hepatology
  
  Volume: 61 Pages: 1032-1039
- DOI
  10.1111/jgh.13645
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-17H06654
[Journal Article] HADHA, the alpha subunit of the mitochondrial trifunctional protein, is involved in long-chain fatty acid-induced autophagy in intestinal epithelial cells.2017
- Author(s)
  Maeyashiki C, Oshima S, Otsubo K, Kobayashi M, Nibe Y, Matsuzawa Y, Onizawa M, Nemoto Y, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Watanabe M
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 484 Pages: 636-641
- DOI
  10.1016/j.bbrc.2017.01.159
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H05286, KAKENHI-PROJECT-16H06771, KAKENHI-PROJECT-15K15288, KAKENHI-PROJECT-16K15423
[Journal Article] The ubiquitin hybrid gene UBA52 regulates ubiquitination of ribosome and sustains embryonic development.2016
- Author(s)
  Kobayashi M, Oshima S, Maeyashiki C, Nibe Y, Otsubo K, Matsuzawa Y, Memoto Y, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Watanabe M
- Journal Title
  
  Sci Rep
  
  Volume: 6 Pages: 36780-36780
- DOI
  10.1038/srep36780
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H05286, KAKENHI-PROJECT-26460963, KAKENHI-PROJECT-15K15288
[Journal Article] PGE2 is a direct and robust mediator of anion/fluid secretion by human intestinal epithelial cells2016
- Author(s)
  Fujii S, Okamoto R, Suzuki K, Kawamoto A, Ishibashi F, Nakata T, Murano T, Ito G, Shimizu H, Mizutani T, Oshima S, Tsuchiya K, Nakamura T, Araki A, Ohtsuka K, Watanabe M
- Journal Title
  
  Sci Rep
  
  Volume: 6 Pages: 36795-36795
- DOI
  10.1038/srep36795
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-15K15286, KAKENHI-PROJECT-16K09302
[Journal Article] Novel CD200 homologues iSEC1 and iSEC2 are gastrointestinal secretory cell-specific ligands of inhibitory receptor CD200R.2016
- Author(s)
  Kojima, T., Tsuchiya, K., Ikemizu, S., Yoshikawa, S., Yamanishi, Y., Watanabe, M., and Karasuyama, H.
- Journal Title
  
  Sci Rep
  
  Volume: 6 Pages: 36457-36457
- DOI
  10.1038/srep36457
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H05786, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-15K20969
[Journal Article] Reduced Human ホア-defensin 6 in Noninflamed Jejunal Tissue of Patients with Crohn's Disease.2016
- Author(s)
  Hayashi R , Tsuchiya K, Okamoto R,Watanabe M,et al
- Journal Title
  
  Inflamm Bowel Dis.
  
  Volume: 22 Pages: 1119-1128
- DOI
  10.1097/mib.0000000000000707
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K15286, KAKENHI-PROJECT-15K15287, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-25460945, KAKENHI-PROJECT-25461031, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-16K09302
[Journal Article] Associations of HLA class I alleles in Japanese patients with Crohn's disease.2015
- Author(s)
  102)Oryoji D, Hisamatsu T, Tsuchiya K, Umeno J, Ueda S, Yamamoto K, Matsumoto T, Watanabe M, Hibi T, Sasazuki T.
- Journal Title
  
  Genes Immun.
  
  Volume: 16 Pages: 54-56
- DOI
  10.1038/gene.2014.61
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-22133009, KAKENHI-PROJECT-24590935, KAKENHI-PUBLICLY-25114703, KAKENHI-PUBLICLY-25130704
[Journal Article] Suppressing TGFβ Signaling in Regenerating Epithelia in an Inflammatory Microenvironment Is Sufficient to Cause Invasive Intestinal Cancer2015
- Author(s)
  Oshima H, Nakayama M, Han TS, Naoi K, Ju X, Maeda Y, Robine S, Tsuchiya K, Sato T, Sato H, Taketo MM, Oshima M.
- Journal Title
  
  Cancer Research
  
  Volume: 75 Pages: 766-776
- DOI
  10.1158/0008-5472.can-14-2036
- NAID
  120005593962
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590935, KAKENHI-PUBLICLY-25114703, KAKENHI-PUBLICLY-25130704, KAKENHI-PROJECT-25430107, KAKENHI-PROJECT-26430110, KAKENHI-PROJECT-25460382
[Journal Article] Atonal homolog 1 protein stabilized by tumor necrosis factor α induces high malignant potential in colon cancer cell line.2015
- Author(s)
  Keita Fukushima, Kiichiro Tsuchiya,Okamoto Ryuichi, Mamoru Watanabe,et al
- Journal Title
  
  Cancer Sci.
  
  Volume: 106 Pages: 1000-1007
- DOI
  10.1111/cas.12703
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K15286, KAKENHI-PROJECT-15K15287, KAKENHI-PROJECT-15K15288, KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-25293170
[Journal Article] TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy.2015
- Author(s)
  Matsuzawa Y, Oshima S, Takahara M, Maeyashiki C, Nemoto Y, Kobayashi M, Nibe Y, Nozaki K, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Averil Ma, Watanabe M
- Journal Title
  
  Autophagy
  
  Volume: 11 Pages: 1052-1062
- DOI
  10.1080/15548627.2015.1055439
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460963, KAKENHI-PROJECT-15K15286, KAKENHI-PROJECT-15K15288, KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-25460946, KAKENHI-PROJECT-25293170
[Journal Article] Anti-Tumor Necrosis Factor Therapy in Inflammatory Bowel Disease.2015
- Author(s)
  Tsuchiya K
- Journal Title
  
  Front Gastrointest Res.
  
  Volume: 34 Pages: 1-8
- DOI
  10.1159/000381380
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K15287, KAKENHI-PROJECT-15H04808
[Journal Article] Reduced human α-defensin 6 in non-inflamed jejunal tissue of Crohn’s disease patients2015
- Author(s)
  Hayashi R , Tsuchiya K, Okamoto R, Watanabe M.et al.
- Journal Title
  
  Inflammatory Bowel Diseases
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293170
[Journal Article] RIPK3 regulates p62- LC3 complex formation via the caspase-8-dependent cleavage of p622015
- Author(s)
  Y. Matsuzawa , S. Oshima, Y. Nibe, M.Kobayashi, C. Maeyashiki, Y. Nemoto, T. Nagaishi, R. Okamoto R, K. Tsuchiya, T. Nakamura, M. Watanabe.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 456(1) Pages: 298-304
- DOI
  10.1016/j.bbrc.2014.11.075
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-24590935, KAKENHI-PROJECT-24590936, KAKENHI-PROJECT-24590937, KAKENHI-PUBLICLY-25114703, KAKENHI-PUBLICLY-25130704, KAKENHI-PROJECT-25293170, KAKENHI-PROJECT-25460946, KAKENHI-PROJECT-26460963, KAKENHI-PROJECT-26221307
[Journal Article] The advances of balloon endoscope2014
- Author(s)
  Araki A, Tsuchiya K, Watanabe M.
- Journal Title
  
  Clinical Journal of Gastroenterology
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460945
[Journal Article] Hes1 promotes the IL-22-mediated antimicrobial response by enhancing STAT3-dependent transcription in human intestinal epithelial cells.2014
- Author(s)
  Murano T, Okamoto R, Ito G, Nakata T, Hibiya S, Shimizu H, Fujii S, Kano Y, Mizutani T, Yui S, Akiyama-Morio J, Nemoto Y, Tsuchiya K, Nakamura T, Watanabe M
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 443 Pages: 840-6
- DOI
  10.1016/j.bbrc.2013.12.061
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590935, KAKENHI-PUBLICLY-25114703, KAKENHI-PUBLICLY-25130704, KAKENHI-PROJECT-25293170, KAKENHI-PROJECT-25670367, KAKENHI-PROJECT-25860524, KAKENHI-PROJECT-26221307
[Journal Article] Distinct expression patterns of Notch ligands, Dll1 and Dll4, in normal and inflamed mice intestine.2014
- Author(s)
  Shimizu H, Okamoto R, Ito G, Nakata T, Suzuki K, Murano T, Mizutani T, Tsuchiya K, Nakamura T, Hozumi K, Watanabe M.
- Journal Title
  
  2014
  
  Volume: 2
- DOI
  10.7717/peerj.370
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-24590935, KAKENHI-PUBLICLY-25114703, KAKENHI-PUBLICLY-25130704, KAKENHI-PROJECT-25293170, KAKENHI-PROJECT-25860524
[Journal Article] Fluorescent labelling of intestinal epithelial cells reveals independent long-lived intestinal stem cells in a crypt.2014
- Author(s)
  N. Horita, K. Tsuchiya, R. Hayashi, K. Fukushima, S. Hibiya, M. Fukuda, Y. Kano, T. Mizutani, Y. Nemoto, S. Yui, R. Okamoto, T. Nakamura, M. Watanabe
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 454 Pages: 493-499
- DOI
  10.1016/j.bbrc.2014.10.091
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-24590935, KAKENHI-PUBLICLY-25114703, KAKENHI-PUBLICLY-25130704, KAKENHI-PROJECT-25293170, KAKENHI-PROJECT-25670367, KAKENHI-PROJECT-25860524, KAKENHI-PROJECT-26221307
[Journal Article] Th1/Th17-mediated interstitial pneumonia in chronic colitis mice independent of intestinal microbiota2013
- Author(s)
  Nemoto Y, Watanabe M et al
- Journal Title
  
  J Immunol
  
  Volume: 190 Pages: 6616-25
- DOI
  10.4049/jimmunol.1202930
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229005, KAKENHI-PROJECT-23590934, KAKENHI-PROJECT-24590935, KAKENHI-PROJECT-24590936, KAKENHI-PROJECT-24659375, KAKENHI-PUBLICLY-25114703, KAKENHI-PUBLICLY-25130704, KAKENHI-PROJECT-25293170, KAKENHI-PROJECT-25670367
[Journal Article] 消化管幹細胞と消化器がん幹細胞2013
- Author(s)
  土屋輝一郎
- Journal Title
  
  日本内科学会雑誌
  
  Volume: 102 Pages: 2273-2278
- NAID
  10031202663
- Data Source
  KAKENHI-PROJECT-24590935
[Journal Article] The acquisition of malignant potential in colon cancer is regulated by the stabilization of Atonal homolog 1 protein2013
- Author(s)
  Kano Y
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 432 Pages: 175-181
- DOI
  10.1016/j.bbrc.2013.01.034
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-22130001, KAKENHI-PLANNED-22130009, KAKENHI-PROJECT-22229005, KAKENHI-PROJECT-23390062, KAKENHI-PROJECT-23659394, KAKENHI-PROJECT-23790357, KAKENHI-PROJECT-23790777, KAKENHI-PROJECT-24590935, KAKENHI-PLANNED-23102003, KAKENHI-PUBLICLY-23130506
[Journal Article] 消化管幹細胞と消化器がん幹細胞2013
- Author(s)
  土屋輝一郎
- Journal Title
  
  日本内科学会雑誌
  
  Volume: 102 Pages: 2273-2278
- NAID
  10031202663
- Data Source
  KAKENHI-PUBLICLY-25130704
[Journal Article] 消化管幹細胞と消化器がん幹細胞2013
- Author(s)
  土屋輝一郎
- Journal Title
  
  日本内科学会雑誌
  
  Volume: 102 Pages: 2273-2278
- NAID
  10031202663
- Data Source
  KAKENHI-PUBLICLY-25114703
[Journal Article] IL-7 promotes long-term in vitro survival of unique long-lived memory subset generated from mucosal effector memory CD4+ T cells in chronic colitis mice2013
- Author(s)
  Takahara M, Nemoto Y, Oshima S, Matsuzawa Y, Kanai T, Okamoto R, Tsuchiya K, Nakamura T, Yamamoto K, Watanabe M.
- Journal Title
  
  Immunol Lett
  
  Volume: 156 Pages: 82-93
- DOI
  10.1016/j.imlet.2013.09.001
- NAID
  120005468269
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-24590935, KAKENHI-PROJECT-24590936, KAKENHI-PUBLICLY-25114703, KAKENHI-PUBLICLY-25130704, KAKENHI-PROJECT-25293170
[Journal Article] 【特集：機能性消化管障害(FGID):診断と治療の進歩】I. FGIDの基本的知識　4. 感染症や腸内細菌の意義（免疫学的異常について）2013
- Author(s)
  土屋輝一郎
- Journal Title
  
  日本内科学会雑誌
  
  Volume: 102 Pages: 25-31
- Data Source
  KAKENHI-PROJECT-24590935
[Journal Article] Lineage-specific expression of bestrophin-2 and bestrophin-4 in human intestinal epithelial cells2013
- Author(s)
  Ito G, Okamoto R, Nakamura T, Watanabe M et al
- Journal Title
  
  PLoS One.
  
  Volume: 8
- DOI
  10.1371/journal.pone.0079693
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229005, KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-24590935, KAKENHI-PROJECT-24590936, KAKENHI-PUBLICLY-25114703, KAKENHI-PUBLICLY-25130704, KAKENHI-PROJECT-25293170, KAKENHI-PROJECT-25460945, KAKENHI-PROJECT-25461031, KAKENHI-PROJECT-25670367, KAKENHI-PROJECT-25860524
[Journal Article] 【特集：機能性消化管障害(FGID):診断と治療の進歩】I. FGIDの基本的知識　4. 感染症や腸内細菌の意義（免疫学的異常について）2013
- Author(s)
  土屋輝一郎
- Journal Title
  
  日本内科学会雑誌
  
  Volume: 102 Pages: 25-31
- Data Source
  KAKENHI-PUBLICLY-25114703
[Journal Article] 【特集：機能性消化管障害(FGID):診断と治療の進歩】I. FGIDの基本的知識　4. 感染症や腸内細菌の意義（免疫学的異常について）.2013
- Author(s)
  土屋輝一郎
- Journal Title
  
  日本内科学会雑誌
  
  Volume: 102 Pages: 25-31
- Data Source
  KAKENHI-PUBLICLY-25130704
[Journal Article] Bone marrow-mesenchymal stem cells are a major source of interleukin-7 and sustain colitis by forming the niche for colitogenic CD4 memory T cells2013
- Author(s)
  Nemoto Y, Nakamura T, Watanabe M et al
- Journal Title
  
  Gut
  
  Volume: 62 Pages: 1142-1152
- DOI
  10.1136/gutjnl-2012-302029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229005, KAKENHI-PROJECT-23590934, KAKENHI-PROJECT-23659394, KAKENHI-PROJECT-23790777, KAKENHI-PROJECT-24590933, KAKENHI-PROJECT-24590935, KAKENHI-PROJECT-24590936, KAKENHI-PROJECT-24659375, KAKENHI-PROJECT-25293170, KAKENHI-PROJECT-25670367, KAKENHI-PLANNED-23102003, KAKENHI-PUBLICLY-23130506
[Journal Article] Real-time analysis of P- gly coprotei n- mediated drug transport across primary intestinal epithelium three-dimensionally cultured in vitro2012
- Author(s)
  Mizutani T, Nakamura T, et al
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 419 Pages: 238-243
- DOI
  10.1016/j.bbrc.2012.01.155
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590803, KAKENHI-PROJECT-21590805, KAKENHI-PUBLICLY-22117508, KAKENHI-PROJECT-22229005, KAKENHI-PROJECT-22590694, KAKENHI-PROJECT-22590695, KAKENHI-PROJECT-22590696, KAKENHI-PLANNED-23102003, KAKENHI-PUBLICLY-23130506, KAKENHI-PROJECT-23590934, KAKENHI-PROJECT-23659394, KAKENHI-PROJECT-23790777, KAKENHI-PROJECT-24390186, KAKENHI-PROJECT-24590936, KAKENHI-PROJECT-24590937, KAKENHI-PUBLICLY-24112508
[Journal Article] Suppression ofhath1 gene expression directly regulated by hes1 via notch signaling is associated with goblet cell depletion in ulcerative colitis.2012
- Author(s)
  Zheng X, Nakamura T, et al
- Journal Title
  
  Inflamm Bowel Di
  
  Volume: 17 Pages: 2251-2260
- DOI
  10.1002/ibd.21611
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590805, KAKENHI-PUBLICLY-22117508, KAKENHI-PROJECT-22229005, KAKENHI-PROJECT-22590694, KAKENHI-PROJECT-22590695, KAKENHI-PUBLICLY-23130506, KAKENHI-PROJECT-23790777, KAKENHI-PROJECT-24659359
[Journal Article] Luminal CD4+ T cells penetrate gut epithelial monolayers and egress from lamina propria to blood circulation.2012
- Author(s)
  Nemoto Y, Watanabe M
- Journal Title
  
  Gastroenterology.
  
  Volume: 141 Pages: 2030-2039
- DOI
  10.1053/j.gastro.2011.08.035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590804, KAKENHI-PROJECT-21590805, KAKENHI-PUBLICLY-22117508, KAKENHI-PROJECT-22229005, KAKENHI-PROJECT-22590694, KAKENHI-PROJECT-22590695, KAKENHI-PUBLICLY-23130506, KAKENHI-PROJECT-23659394, KAKENHI-PROJECT-23790777
[Journal Article] Modified single-operator method for double-balloonendoscopy2012
- Author(s)
  Araki A, Suzuki S, Tsuchiya K, OshimaS, Okada E, Watanabe M
- Journal Title
  
  Dig Endosc.
  
  Volume: 24(6) Pages: 470-4
- DOI
  10.1111/j.1443-1661.2012.01321.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590694, KAKENHI-PROJECT-22590695, KAKENHI-PROJECT-24590935, KAKENHI-PUBLICLY-23130506
[Journal Article] Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5(+) stem cell.2012
- Author(s)
  Yui S, Nakamura T, Sato T, Nemoto Y, Mizutani T, Zheng X, Ichinose S, Nagaishi T, Okamoto R, Tsuchiya K, Clevers H, and Watanabe M
- Journal Title
  
  Nat. Med.
  
  Volume: 18 Pages: 618-23
- DOI
  10.1038/nm.2695
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590803, KAKENHI-PROJECT-21590805, KAKENHI-PROJECT-21590806, KAKENHI-PUBLICLY-22117508, KAKENHI-PROJECT-22229005, KAKENHI-PROJECT-22590694, KAKENHI-PROJECT-22590695, KAKENHI-PROJECT-22590696, KAKENHI-PLANNED-23102003, KAKENHI-PUBLICLY-23130506, KAKENHI-PROJECT-23590934, KAKENHI-PROJECT-23659394, KAKENHI-PROJECT-23790777, KAKENHI-PROJECT-23890204, KAKENHI-PROJECT-24390186, KAKENHI-PROJECT-24590936, KAKENHI-PROJECT-24590937, KAKENHI-PROJECT-24689036, KAKENHI-PROJECT-24790684, KAKENHI-PUBLICLY-24112508, KAKENHI-PUBLICLY-24112523
[Journal Article] Endoscopic ultrasound with double-balloon endoscopy for the diagnosis of inverted Meckel's diverticulum: a case report2012
- Author(s)
  Araki A, Tsuchiya K, Oshima S, Okada E,Suzuki S, Akiyama JM, Fujii T, OkamotoR, Watanabe M
- Journal Title
  
  J Med Case Rep.
  
  Volume: 6(1) Pages: 328-328
- DOI
  10.1186/1752-1947-6-328
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590694, KAKENHI-PROJECT-22590695, KAKENHI-PROJECT-23590934, KAKENHI-PROJECT-23790776, KAKENHI-PROJECT-23790777, KAKENHI-PROJECT-24590935, KAKENHI-PLANNED-23102003, KAKENHI-PUBLICLY-23130506
[Journal Article] The development of colitogenic CD4+ T cells is regulated by IL-7 in collaboration with NK cell function in a murine model of colitis.2012
- Author(s)
  Yamaji O, Totsuka T
- Journal Title
  
  J. Immunol
  
  Volume: 188 Pages: 2524-2536
- DOI
  10.4049/jimmunol.1100371
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590804, KAKENHI-PROJECT-21590805, KAKENHI-PROJECT-21590806, KAKENHI-PUBLICLY-22117508, KAKENHI-PROJECT-22229005, KAKENHI-PROJECT-22590694, KAKENHI-PROJECT-22590695, KAKENHI-PROJECT-22590696, KAKENHI-PUBLICLY-23130506, KAKENHI-PROJECT-23390112, KAKENHI-PROJECT-23590934, KAKENHI-PROJECT-23659223, KAKENHI-PROJECT-23659394, KAKENHI-PROJECT-23790777, KAKENHI-PROJECT-24590936, KAKENHI-PROJECT-24590937, KAKENHI-PLANNED-23102003
[Journal Article] Analysis of interferon signaling by infectious hepatitis C virus clones with substitutions of core amino acids 70 and 912011
- Author(s)
  Funaoka Y, Sakamoto N, Suda G, Itsui Y, Nakagawa M, Kakinuma S, Watanabe T, Nitta S, Kitazume A, Kiyohashi K, Murakawa M, Azuma S, Tsuchiya K,Watanabe M
- Journal Title
  
  J Virol
  
  Volume: 85 Pages: 5986-5994
- DOI
  10.1128/jvi.02583-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-21590832, KAKENHI-PROJECT-22790633, KAKENHI-PUBLICLY-23130506
[Journal Article] The suppression of Hath1 gene expression directly regulated by Hes1 via Notch signaling is associated with goblet cell depletion in ulcerative colitis.2011
- Author(s)
  Zheng X, Tsuchiya K, Okamoto R, Iwasaki M, Kano Y, Sakamoto N, Nakamura T, Watanabe M
- Journal Title
  
  Inflamm Bowel Dis. in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790653
[Journal Article] Upregulated IL-7Rα expression on colitogenic memory CD4+ T cells may participate in the development and persistence of chronic colitis2011
- Author(s)
  Shinohara, T., et al
- Journal Title
  
  J Immunol
  
  Volume: 186 Pages: 2623-2632
- DOI
  10.4049/jimmunol.1000057
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590531, KAKENHI-PROJECT-21590805, KAKENHI-PUBLICLY-22117508, KAKENHI-PROJECT-22229005, KAKENHI-PROJECT-22590694, KAKENHI-PROJECT-22590695, KAKENHI-PUBLICLY-23130506
[Journal Article] Magnetic resonance enterocolonography is useful for simultaneous evaluation of small and large intestinal lesions in Crohn's disease.2011
- Author(s)
  Hyun SB, Kitazume Y, Suzuki S, Watanabe M, et al
- Journal Title
  
  Inflamm Bowel Dis.
  
  Volume: 17 Pages: 1063-1072
- DOI
  10.1002/ibd.21510
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590805, KAKENHI-PROJECT-21590806, KAKENHI-PROJECT-22590694, KAKENHI-PROJECT-22590695, KAKENHI-PROJECT-22590696, KAKENHI-PUBLICLY-23130506, KAKENHI-PROJECT-23590934
[Journal Article] Longitudinal cell formation in the entire human small intestine is correlated with the localization of Hathl and KIN.2011
- Author(s)
  Iwasaki M, Tsuchiya K, Araki A, Watanabe M, et al.
- Journal Title
  
  J Gastroenterol.
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590694
[Journal Article] Upregulated IL-7 Receptor {alpha} Expression on Colitogenic Memory CD4+ T Cells May Participate in the Development and Persistence of Chronic Colitis.2011
- Author(s)
  Shinohara T, Nemoto Y, Kanai T, Kameyama K, Okamoto R, Tsuchiya K, Nakamura T, Totsuka T, Ikuta K, Watanabe M
- Journal Title
  
  J Immunol. in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790653
[Journal Article] Longitudinal cell formation in the entire human small intestine is correlated with the localization of Hath1 and Klf4.2011
- Author(s)
  Iwasaki M, Tsuchiya K, Suzuki S, Watanabe M, et al
- Journal Title
  
  J Gastroenterol.
  
  Volume: 46 Pages: 191-202
- DOI
  10.1007/s00535-010-0346-x
- NAID
  10029027237
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590805, KAKENHI-PROJECT-22590694, KAKENHI-PROJECT-22590695, KAKENHI-PUBLICLY-23130506, KAKENHI-PROJECT-23790777
[Journal Article] The suppression of Hath1 gene expression directly regulated by Hes1 via Notch signaling is associated with goblet cell depletion in ulcerative colitis.2011
- Author(s)
  Zheng X, Tsuchiya K, Watanabe M, et al.
- Journal Title
  
  Inflamm Bowel Dis.
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790653
[Journal Article] Inhibitory effect of a triterpenoid compound, with or without interferon-alpha, on hepatitis C virus infection2011
- Author(s)
  Watanabe T, Sakamoto N, Nakagawa M, Azuma S, Watanabe M, et al.
- Journal Title
  
  Antimicrobial Agents and Chemotherapy
  
  Volume: 55(6) Pages: 2537-2545
- DOI
  10.1128/aac.01780-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390226, KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-21590832, KAKENHI-PROJECT-22659145, KAKENHI-PROJECT-22790633, KAKENHI-PUBLICLY-23130506, KAKENHI-PROJECT-23790778
[Journal Article] Cell culture and in-vivo analyses of plaque-derived cytopathic hepatitis C virus mutants.2010
- Author(s)
  Mishima K, Tsuchiya K, Watanabe M(他12名、10番目)
- Journal Title
  
  Virology. 405(2)
  
  Pages: 361-369
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790653
[Journal Article] Delta-like 1 expression promotes goblet cell differentiation in Notch-inactivated human colonic epithelial cells.2010
- Author(s)
  Akiyama J, Tsuchiya K, Watanabe M(他5名、6番目)
- Journal Title
  
  Biochemical and Biophysical Research Communications. 393
  
  Pages: 662-667
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790653
[Journal Article] Magnetic resonance enterocolonography is u seful for simultaneous evaluation of small and large intestinal lesions in Crohn's disease.2010
- Author(s)
  Hyun SB, Tsuchiya K, Okada E, Araki A, Watanabe M.
- Journal Title
  
  Inflamm Bowel Dis.
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590694
[Journal Article] Longitudinal cell formation in the entire human small intestine is correlated with the localization of Hath1 and Klf4.2010
- Author(s)
  Iwasaki M, Tsuchiya K, Watanabe M, et al.
- Journal Title
  
  J Gastroenterol.
  
  Volume: (in press)
- NAID
  10029027237
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790653
[Journal Article] Comparison of HCV-associated gene expression and cell signaling pathways in cells with or without HCV replicon and in replicon-cured cells.2010
- Author(s)
  Nishimura-Sakurai Y, Tsuchiya K, Watanabe M(他18名、18番目)
- Journal Title
  
  J Gastroenterol. 45
  
  Pages: 523-536
- NAID
  10027216127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790653
[Journal Article] IL-2 is positively involved in the development of colitogenic CD4+ IL-7R alpha high memory T cells in chronic colitis.2010
- Author(s)
  Kameyama K, Tsuchiya K, Watanabe M(他8名、6番目)
- Journal Title
  
  Eur J Immunol 40(9)
  
  Pages: 2423-2436
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790653
[Journal Article] Magnetic resonance enterocolonography is useful for simultaneous evaluation of small and large intestinal lesions in Crohn's disease.2010
- Author(s)
  Hyun SB, Kitazume Y, Nagahori M, Toriihara A, Fujii T, Tsuchiya K, Suzuki S, Okada E, Araki A, Naganuma M, Watanabe M.
- Journal Title
  
  Inflamm Bowel Dis. in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790653
[Journal Article] Inhibition of HCV replication by a specific inhibitor of serin-arginine-rich protein kinase.2010
- Author(s)
  Karakama Y, Tsuchiya K, Watanabe M(他10名、10番目)
- Journal Title
  
  Antimicrob Agent Chemother. 54(8)
  
  Pages: 3179-3186
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790653
[Journal Article] Delta-like 1 expression promotes goblet cell differentiation in Notch-inactivated human colonic epithelial cells.2010
- Author(s)
  Akiyama J, Tsuchiya K, Watanabe M, et al.
- Journal Title
  
  Biochemical and Biophysical Research Communications.
  
  Volume: 393 Pages: 662-667
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790653
[Journal Article] IL-6-mediated intersubgenotypic variation of interferon sensitivity in hepatitis C virus genotype 2a/2b chimeric clones.2010
- Author(s)
  Suda G, Tsuchiya K, Watanabe M(他15名、14番目)
- Journal Title
  
  Virology. 407(1)
  
  Pages: 80-90
- Data Source
  KAKENHI-PROJECT-21790653
[Journal Article] Longitudinal cell formation in the entire human small intestine is correlated with the localization of Hath1 and Klf4.2010
- Author(s)
  Iwasaki M, Tsuchiya K, Okamoto R, Zheng X, Kano Y, Okamoto E, Okada E, Araki A, Suzuki S, Sakamoto N, Kitagaki K, Akashi T, Eishi Y, Nakamura T, Watanabe M
- Journal Title
  
  J Gastroenterol in press
- NAID
  10029027237
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790653
[Journal Article] Delta-like 1 expression promotes goblet cell differentiation in Notch-inactivated human colonic epithelial cells2010
- Author(s)
  Akiyama J, Tsuchiya K, et al.
- Journal Title
  
  Biochemical and Biophysical Research Communications (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790653
[Journal Article] Requirement of Notch activation duringregeneration of the intestinal epithelia2009
- Author(s)
  Okamoto R, Tsuchiya K, Nemoto Y, AkiyamaJ, Nakamura T, Kanai T, Watanabe M
- Journal Title
  
  Am JPhysiol GI & Liver 296
  
  Pages: 23-35
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590717
[Journal Article] Requirement of Notch activation during regeneration of the intestinal epithelia2009
- Author(s)
  Okamoto R, Tsuchiya K, Nemoto Y, Akiyama J, Nakamura T, Kanai T, Watanabe M
- Journal Title
  
  Am J Physiol GI & Liver 296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209027
[Journal Article] Musashi-1 suppresses expression of Paneth cell-specificgenes in human intestinal epithelial cells.2009
- Author(s)
  Murayama M. Tsuchiya K, etal.
- Journal Title
  
  J Gastroenterol. (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590717
[Journal Article] RANK-RANKL signaling pathway is critically involved in the function of CD4+CD25+ regulatory T Cells in chronic colitis2009
- Author(s)
  Totsuka T, Kanai T, Nemoto Y, Tomita T, Okamoto R, Tsuchiya K, Nakamura T, Sakamoto N, Akiba H, Okumura K, Yagita H, Watanabe M
- Journal Title
  
  J Immunol. 182
  
  Pages: 6079-6087
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209027
[Journal Article] Requirement of Notch activation during regeneration of the intestinal epithelia2009
- Author(s)
  Okamoto R, Tsuchiya K, et al.
- Journal Title
  
  Am J Physiol GI & Liver 296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790653
[Journal Article] Signaling pathway via TNFα/NFκB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis2009
- Author(s)
  Onizawa M, Tsuchiya K, et al.
- Journal Title
  
  Am J Physiol GI & Liver 296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790653
[Journal Article] Musashi-1 suppresses expression of Paneth cell specific genes in human intestinal epithelial cells.2009
- Author(s)
  Murayama M, Tsuchiya K, Watanabe M(他6名、3番目)
- Journal Title
  
  J Gastroenterol. 44
  
  Pages: 173-182
- NAID
  10025173646
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790653
[Journal Article] Long-Lived colitogenic CD4+ Memory T Cells residing outside the intestine participate in the perpetuation of chronic colitis2009
- Author(s)
  Nemoto Y, Kanai T, Kameyama K, Shinohara T, Sakamoto N, Totsuka T, Okamoto R, Tsuchiya K, Nakamura T, Sudo T, Matsumoto S, Watanabe M
- Journal Title
  
  J Immunol. 183
  
  Pages: 5059-5068
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209027
[Journal Article] Requirement of Notch activation during regeneration of theintestinal epithelia.2009
- Author(s)
  Okamoto R. Tsuchiya K, et al.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol 296
  
  Pages: 23-35
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590717
[Journal Article] Long-Lived Colitogenic CD4+ Memory T Cells Residing Outside the Intestine Participate in the Perpetuation of Chronic Colitis.2009
- Author(s)
  Nemoto Y, Tsuchiya K, Watanabe M(他9名、8番目)
- Journal Title
  
  J Immunol 183
  
  Pages: 5059-5068
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790653
[Journal Article] Musashi-1 suppresses expression of Paneth cell specific genes in human intestinal epithelial cells2009
- Author(s)
  Murayama M, Tsuchiya K, et al.
- Journal Title
  
  J Gastroenterol. 44
  
  Pages: 173-182
- NAID
  10025173646
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790653
[Journal Article] Long-Lived colitogenic CD4+ Memory T Cells residing outside the intestine participate in the perpetuation of chronic colitis2009
- Author(s)
  Nemoto Y, Tsuchiya K, et al.
- Journal Title
  
  J Immunol. 183
  
  Pages: 5059-5068
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790653
[Journal Article] Signaling pathway via TNF α /NF κ B in intestinal epithelial cellsmay be directly involved in colitis-associated carcinogenesis.2009
- Author(s)
  Onizawam, Tsuchiya K, etal
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590717
[Journal Article] RANK-RANKL Signaling Pathway Is Critically Involved in the Function of CD4+CD25+ Regulatory T Cells in Chronic Colitis.2009
- Author(s)
  Totsuka T, Tsuchiya K, Watanabe M(他9名、6番目)
- Journal Title
  
  J Immunol. 182
  
  Pages: 6079-6087
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790653
[Journal Article] Requirement of Notch activation during regeneration of the intestinal epithelia.2009
- Author(s)
  Okamoto R, Tsuchiya K, Watanabe M(他4名、2番目)
- Journal Title
  
  Am J Physiol GI & Liver. 296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790653
[Journal Article] Single-operator double-balloon endoscopy (DBE) is as effective as dual-operator DBE.2009
- Author(s)
  Araki A, Tsuchiya K, Watanabe M.(他6名、2番目)
- Journal Title
  
  J Gastroenterol Hepatol. 24(5)
  
  Pages: 770-775
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790653
[Journal Article] RANK-RANKL signaling pathway is critically involved in the function of CD4+CD25+ regulatory T Cells in chronic colitis2009
- Author(s)
  Totsuka T, Tsuchiya K, et al.
- Journal Title
  
  J Immunol. 182
  
  Pages: 6079-3087
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790653
[Journal Article] IL-7 is essential for lymphopenia-driven turnover of colitogenic CD4+ memory T cells in chronic colitis2009
- Author(s)
  Tomita T, Tsuchiya K, et al.
- Journal Title
  
  Eur J Immunol. 39
  
  Pages: 2737-2747
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790653
[Journal Article] Signaling pathway via TNF α/NFκB in intestinal epithelial cells may bedirectly involved in colitis- associated carcinogenesis.2009
- Author(s)
  Onizawa M, Tsuchiya K, Watanabe M(他13名、12番目)
- Journal Title
  
  Am J Physiol GI & Liver. 296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790653
[Journal Article] Single-operator double-balloon endoscopy2009
- Author(s)
  Arake A, Tsuchiya K, etal
- Journal Title
  
  J Gastroenterol Hepatol. (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590717
[Journal Article] Colitogenic CD4^+ effector-memory T cells actively recirculate in chronic coliticmice2008
- Author(s)
  Tomita T, Kanai T, Nemoto Y, Fujii T, Okamoto R, Tsuchiya K, Nakamura T, Sakamoto N, Totsuka T, Watanabe M
- Journal Title
  
  Inflamm Bowel Dis 14
  
  Pages: 1630-1640
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590717
[Journal Article] Negative feedback regulation of colitogenic CD4+ T cells by increased granulopoiesis2008
- Author(s)
  Nemoto Y, Kanai T, Tohda S, Totsuka T, Okamoto R, Tsuchiya K, Nakamura T, Sakamoto N, Fukuda T, Miura O, Yagita H, Watanabe M
- Journal Title
  
  Inflamm Bowel Dis 14
  
  Pages: 1491-1503
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590717
[Journal Article] Proteasomal degradation of Atoh1 by aberrant Wnt signaling maintains the undifferentiated state ofcolon cancer2008
- Author(s)
  Aragaki M, Tsuchiya K, Okamoto R, Yoshioka S, Nakamura T, Sakamoto N, KanaiT, Watanabe M
- Journal Title
  
  Biochem Biophys Res Commun 368
  
  Pages: 923-929
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590717
[Journal Article] Systemic, but not intestinal, IL-7 is essential for the persistence ofchronic colitis2008
- Author(s)
  Tomita T, Kanai T, Nemoto Y, Totsuka T, Okamoto R, Tsuchiya K, Sakamoto N, Watanabe M
- Journal Title
  
  J Immunol 180
  
  Pages: 383-390
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590717
[Journal Article] Proteasomal degradation of Atohl by aberrant Wnt signaling maintains the undifferentiated state of colon cancer.2008
- Author(s)
  Aragaki M, Tsuchiya K, et. al.
- Journal Title
  
  Biochem Biophys Res Commun. 368
  
  Pages: 923-929
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590717
[Journal Article] Systemic, but not intestinal, IL-7 is essential for the persistence of chronic colitis.2008
- Author(s)
  Tomita T, Tsuchiya K, et. al.
- Journal Title
  
  J Immunol. 180
  
  Pages: 383-390
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590717
[Journal Article] MyD88-dependent pathway in T cells directly modulates the expansion and survival of colitogenic CD4+ T cells in chronic colitis2008
- Author(s)
  Tomita T, Kanai T, Fujii T, Nemoto Y, Okamoto R, Tsuchiya K, Totsuka T, SakamotoN, Akira S, Watanabe M
- Journal Title
  
  J Immunol 180
  
  Pages: 5291-5299
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590717
[Journal Article] MyD88-dependent pathway in T cells directly modulates the expansion and survival of colitogenic CD4+ T cells in chronic colitis2008
- Author(s)
  Tomita T, Kanai T, Fujii T, Nemoto Y, Okamoto R, Tsuchiya K, Totsuka T, Sakamoto N, Akira S, Watanabe M
- Journal Title
  
  J Immunol. 180
  
  Pages: 5291-5299
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209027
[Journal Article] MyD88-dependent pathway in T Cells directly modulates the expansion of colitogenic CD4+ T Cells in chronic colitisl.2008
- Author(s)
  Tomita T, Tsuchiya K, et. al.
- Journal Title
  
  J Immunol. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590717
[Journal Article] Immunosenescent colitogenic CD4+ T cells convert to regulatory cells and suppress colitis.2008
- Author(s)
  Totsuka T, Tsuchiya K, et. al.
- Journal Title
  
  Eur J Immunol. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590717
[Journal Article] Systemic, but not intestinal, IL-7 is essential for the persistence of chronic colitis2008
- Author(s)
  Tomita T, Kanai T, Nemoto Y, Totsuka T, Okamoto R, Tsuchiya K, Sakamoto N, Watanabe M
- Journal Title
  
  J Immunol. 180
  
  Pages: 383-390
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209027
[Journal Article] Inducible expression of microRNA-194 is regulated byHNF-1a during intestinal epithelial cell differentiation.2008
- Author(s)
  Hino K, Tsuchiya K., et al.
- Journal Title
  
  RNA 14
  
  Pages: 1433-1442
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590717
[Journal Article] Flagellin stimulation suppresses IL-7 secretion of intestinalepithelial cells.2008
- Author(s)
  Yoshioka A, Tsuchiya K, et al.
- Journal Title
  
  Cytokine 44
  
  Pages: 57-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590717
[Journal Article] Negative Feedback Regulation of Colitogenic CD4 T Cellsby Increased Granulopoiesis.2008
- Author(s)
  Nemoto YごTsuchiya K., et al.
- Journal Title
  
  Inflamm Bowel Dis 14
  
  Pages: 1491-1503
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590717
[Journal Article] Colitogenic CD4 Effector-memory T Cells ActivelyRecirculate in Chronic Colitic Mice.2008
- Author(s)
  Tomita T, Tsuchiya K, et al.
- Journal Title
  
  Inflamm Bowel Dis 14
  
  Pages: 1630-1640
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590717
[Journal Article] Inducible expression of microRNA-194 is regulated by HNF-1 during intestinal epithelial cell differentiation2008
- Author(s)
  Hino K, Tsuchiya K, Taro Fukao, KotaroKiga, Ryuichi Okamoto, Tkanori Kanai, Watanabe M
- Journal Title
  
  RNA 14
  
  Pages: 1433-1442
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590717
[Journal Article] FTY720 suppresses the development of colitis in lymphoid-null mice bymodulating the trafficking of colitogenic CD4十T cells in bone marrow.2008
- Author(s)
  Fujii T. Tsuchiya K, et al.
- Journal Title
  
  Eur J Immunol. 38
  
  Pages: 3290-3303
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590717
[Journal Article] IL-7 is essential for the development and the persistence of chronic colitis running title : IL-7-dependent colitis.2007
- Author(s)
  Totsuka T, Tsuchiya K, et al.
- Journal Title
  
  J Immunol. (in press)
- Data Source
  KAKENHI-PROJECT-17590621
[Journal Article] IL-7 is essential for the development and the persistence of chronic colitis2007
- Author(s)
  Totsuka T, Kanai T, Nemoto Y, Makita S, Okamoto R, Tsuchiya K, Watanabe M
- Journal Title
  
  J Immunol. 178
  
  Pages: 4737-4748
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209027
[Journal Article] IL-7 is essential for the development and the persistence of chronic colitis.2007
- Author(s)
  Totsuka T, Tsuchiya K, et al.
- Journal Title
  
  J Immunol. 178
  
  Pages: 4737-4748
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590621
[Journal Article] Reciprocal targeting of Hath1 and β-catenin by Wnt-glycogen synthase kinase 3β in human colon cancer.2007
- Author(s)
  Tsuchiya K, et al.
- Journal Title
  
  Gastroenterology 132
  
  Pages: 208-220
- NAID
  40015644487
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590621
[Journal Article] Reciprocal targeting of Hath1 and β-catenin by Wnt-glycogen synthase kinase 3 β in human colon cancer.2007
- Author(s)
  Tsuchiya K, Watanabe M, et al.
- Journal Title
  
  Gastroenterology. 132
  
  Pages: 208-220
- NAID
  40015644487
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17209027
[Journal Article] Reciprocal targeting of Hath1 and β-catenin by Wnt-glycogen synthase kinase 3β in human colon cancer2007
- Author(s)
  Tsuchiya K, Nakamura T, Okamoto R, Kanai T, Watanabe M
- Journal Title
  
  Gastroenterology 132
  
  Pages: 208-220
- NAID
  40015644487
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590717
[Journal Article] Reciprocal targeting of Hath1 and β -catenin by Wnt-glycogen synthase kinase 3 β in human colon cancer.2007
- Author(s)
  Tsuchiya K, et al.
- Journal Title
  
  Gastroenterology. 132
  
  Pages: 208-220
- NAID
  40015644487
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590621
[Journal Article] Intestinal Lamina Propria Retaining CD4+CD25+Regulatory T Cells Is A Suppressive Site of Intestinal Inflammation.2007
- Author(s)
  Makita S, Tsuchiya K, et al.
- Journal Title
  
  J Immunol. (in press)
- Data Source
  KAKENHI-PROJECT-17590621
[Journal Article] Reciprocal targeting of Hath1 and β-catenin by Wnt-glycogen synthase kinase 3 β in human colon cancer.2007
- Author(s)
  Tsuchiya K, et al.
- Journal Title
  
  Gastroenterology. 132
  
  Pages: 208-220
- NAID
  40015644487
- Data Source
  KAKENHI-PROJECT-17590621
[Journal Article] Reciprocal targeting of Hath1 and β-catenin by Wnt-glycogen synthase kinase 3βin human colon cancer.2007
- Author(s)
  Tsuchiya K, Watanabe M, et al.
- Journal Title
  
  Gastroenterology. 132
  
  Pages: 208-220
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209027
[Journal Article] Reciprocal targeting of Hath1 and β-catenin by Wnt-glycogen synthase kinase 3 β in human colon cancer.2007
- Author(s)
  Tsuchiya K, Watanabe M, et al.
- Journal Title
  
  Gastroenterology. 132
  
  Pages: 208-220
- NAID
  40015644487
- Data Source
  KAKENHI-PROJECT-17047015
[Journal Article] Intestinal Lamina Propria retaining (CD4+CD25+) Regulatory T Cells Is A Suppressive Site of Internal Inflammation.2007
- Author(s)
  Makita S, Tsuchiya K, et al.
- Journal Title
  
  J Immunol. 178
  
  Pages: 4937-4046
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590621
[Journal Article] Reciprocal targeting of Hath1 and β-catenin by Wnt-glycogen synthase kinase 3β in human colon cancer.2007
- Author(s)
  Tsuchiya K, Watanabe M, et al.
- Journal Title
  
  Gastroenterology. 132
  
  Pages: 208-220
- NAID
  40015644487
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590624
[Journal Article] Intestinal lamina propria retaining CD4+CD25+regulatory T cells is a suppressive site of intestinal inflammation.2007
- Author(s)
  Makita S, Tsuchiya K, et. al.
- Journal Title
  
  J Immunol. 178
  
  Pages: 4937-4946
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590717
[Journal Article] Crosstalk between Wnt and Notch signaling in intestinal epithelial cell fate decision.2007
- Author(s)
  Nakamura T, Tsuchiya K, et. al.
- Journal Title
  
  J Gastroenterol. 42
  
  Pages: 705-710
- NAID
  10019816553
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590717
[Journal Article] Blockade of NKG2D signaling prevents the development of murine CD4+ T cell-mediated colitis.2007
- Author(s)
  Ito Y, Tsuchiya K, et. al.
- Journal Title
  
  Am J Physiol GI & Liver. 394
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590717
[Journal Article] IL-7 is essential for the development and the persistence of chronic colitis.2007
- Author(s)
  Totsuka T, Tsuchiya K, et. al.
- Journal Title
  
  J Immunol. 178
  
  Pages: 4737-4748
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590717
[Journal Article] IL-7 is essential for the development and the persistence of chronic colitis.2007
- Author(s)
  Totsuka T, Tsuchiya K, Watanabe M, et al.
- Journal Title
  
  J Immunol. 178
  
  Pages: 4737-4748
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590624
[Journal Article] Intestinal lamina propria retaining CD4+CD25+ regulatory T cells is a suppressive site of intestinal inflammation2007
- Author(s)
  Makita S, Kanai T, Nemoto Y, Totsuka T, Okamoto R, Tsuchiya K, Yamamoto M, Kiyono H, Watanabe M
- Journal Title
  
  J Immunol. 178
  
  Pages: 4937-4946
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209027
[Journal Article] Reciprocal targeting of Hath1 and β-catenin by Wnt-glycogen synthase kinase 3β in human colon cancer.2007
- Author(s)
  Tsuchiya K, Watanabe M, et. al.
- Journal Title
  
  Gastroenterology. 132
  
  Pages: 208-220
- NAID
  40015644487
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209027
[Journal Article] Intestinal lamina propria retaining CD4+CD25+ regulatory T cells is a suppressive site of intestinal inflammation2007
- Author(s)
  Makita S, Kanai T, Nemoto Y, Totsuka T, Okamoto R, Tsuchiya K, Yamamoto M, Kiyono H, Watanabe M
- Journal Title
  
  J Immunol 178
  
  Pages: 4937-4946
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590717
[Journal Article] Reciprocal targeting of Hathl and β-catenin by Wnt-glycogen synthase kinase 3 β in human colon cancer.2007
- Author(s)
  Tsuchiya K, Watanabe M, et. al.
- Journal Title
  
  Gastroenterology. 132
  
  Pages: 208-220
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590717
[Journal Article] IL-7 is essential for the development and the persistence of chronic colitis2007
- Author(s)
  Totsuka T, Kanai T, Nemoto Y, Makita S, Okamoto R, Tsuchiya K, Watanabe M
- Journal Title
  
  J Immunol 178
  
  Pages: 4737-4748
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590717
[Journal Article] Intestinal lamina propria retaining CD4+CD25+ regulatory T cells is a suppressive site of intestinal inflammation.2007
- Author(s)
  Makita S, Tsuchiya K, Watanabe M, et al.
- Journal Title
  
  J Immunol. 178
  
  Pages: 4937-4946
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590624
[Journal Article] Intestinal Lamina Propria Retaining CD4+CD25+ Regulatory T Cells Is A Suppressive Site of Intestinal Inflammation.2007
- Author(s)
  Makita S, Tsuchiya K, et al.
- Journal Title
  
  J Immunol. 178
  
  Pages: 4937-4946
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590621
[Journal Article] FTY720 suppresses CD4^+CD44^<high>CD62L^- effector memory T cell-mediated colitis2006
- Author(s)
  Fujii R, Tsuchiya K, Watanabe M, et al.
- Journal Title
  
  Am J Physiol. 291
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590624
[Journal Article] FTY720 suppresses CD4^+CD44^<high>CD62L^- effector memory T cell-mediated colitis.2006
- Author(s)
  Fujii R, Tsuchiya K, et al.
- Journal Title
  
  Am J Physiol. 291
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590621
[Journal Article] FTY720 suppresses CD4^+CD44^<high>CD62L effector memory T cell-mediated colitis.2006
- Author(s)
  Fujii R, Tsuchiya K, et al.
- Journal Title
  
  Am J Physiol. 291
- Data Source
  KAKENHI-PROJECT-17590621
[Journal Article] FTY720 suppresses CD4^+CD44^<high>CD62L^- effector memory T cell-mediated colitis.2006
- Author(s)
  Fujii R, Tsuchiya K, Watanabe M, et al.
- Journal Title
  
  Am J Physiol. 291
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590624
[Journal Article] IL-7 exacerbates chronic colitis with expansion of memory IL-7R^<high> CD4^+ mucosal T cells in mice.2005
- Author(s)
  Okada E, Tsuchiya K, et al.
- Journal Title
  
  Am J Physiol. 291
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590621
[Journal Article] Increase of bone marrow-derived secretory lineage epithelial cells during regeneration in the human intestine.2005
- Author(s)
  Matsumoto T, Tsuchiya K, Watanabe M, et al.
- Journal Title
  
  Gastroenterology. 128
  
  Pages: 1851-1867
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590624
[Journal Article] IRF-1 mediates upregulation of LMP7 by IFN-gamma and concerted expression of immunosubunits of the proteasome.2005
- Author(s)
  Namiki S, Tsuchiya K, Watanabe M, et al.
- Journal Title
  
  FEBS Lett. 579
  
  Pages: 2781-2787
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590624
[Journal Article] Increase of bone marrow-derived secretory lineage epithelia cells during regeneration in the human intestine.2005
- Author(s)
  Matsumoto T, Tsuchiya K, et al.
- Journal Title
  
  Gastroenterology 128
  
  Pages: 1851-1867
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590621
[Journal Article] IRF-1 mediates upregulation of LMP7 by IFN-gamma and concerted expression of immunosubunits of the proteasome.2005
- Author(s)
  Namiki S, Tsuchiya K, et al.
- Journal Title
  
  FEBS Lett. 579
  
  Pages: 2781-2787
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590621
[Journal Article] Increase of bone marrow-derived secretory lineage epithelial cells during regeneration in the human intestine.2005
- Author(s)
  Matsumoto T, Tsuchiya K, et al.
- Journal Title
  
  Gastroenterology. 128
  
  Pages: 1851-1867
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590621
[Journal Article] Increase of bone marrow-derived secretory lineage epithelial cells during regeneration in the human intestine.
- Author(s)
  Matsumoto T, Tsuchiya K, Watanabe M, et al.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590624
[Patent] ダブルバルーン内視鏡用係止具及び内視鏡用アダプタ2013
- Inventor(s)
  荒木昭博、土屋輝一郎、大島茂
- Industrial Property Rights Holder
  国立大学法人東京医科歯科大学
- Acquisition Date
  2013-10-12
- Data Source
  KAKENHI-PROJECT-22590694
[Presentation] TP53 mutation in human colonic organoids acquires resistance to in vitro long-term inflammation.2019
- Author(s)
  Tsuchiya K, Watanabe S, Shirasaki T, Nishimura R, Katsukura N, Hibiya S, Okamoto R, Nakamura T, Watanabe M
- Organizer
  ECCO2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02791
[Presentation] TP53 mutation in human colonic organoids acquires resistance to in vitro long-term inflammation.2019
- Author(s)
  Tsuchiya K, Watanabe S, Shirasaki T, Nishimura R, Katsukura N, Hibiya S, Okamoto R, Nakamura T, Watanabe M
- Organizer
  ECCO2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19535
[Presentation] Synergy of Notch signalling and TNF-α in the inflamed intestinal epithelia of IBD patients leads to up-regulation of UBD, a ubiquitin-like protein.2019
- Author(s)
  Kawamoto A, Nagata S, Anzai S, Takahashi J, Kawai M, Hama M, Nogawa D, Yamamoto K, Kuno R, Suzuki K, Shimizu H, Hiraguri Y, Yui S, Oshima S, Tsuchiya K, Nakamura T, Ohtsuka K, Kitagawa M, Okamoto R, Watanabe M
- Organizer
  ECCO2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221307
[Presentation] Synergy of Notch signalling and TNF-α in the inflamed intestinal epithelia of IBD patients leads to up-regulation of UBD, a ubiquitin-like protein.2019
- Author(s)
  Kawamoto A, Nagata S, Anzai S, Takahashi J, Kawai M, Hama M, Nogawa D, Yamamoto K, Kuno R, Suzuki K, Shimizu H, Hiraguri Y, Yui S, Oshima S, Tsuchiya K, Nakamura T, Ohtsuka K, Kitagawa M, Okamoto R, Watanabe M
- Organizer
  ECCO2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19535
[Presentation] UC-related and segment-specific properties of patientderived colonic organoids.2019
- Author(s)
  Suzuki K, Shimizu H, Kawai M, Takahashi J, Anzai S, Kawamoto A, Nagata S, Hiraguri Y, Yui S, Tsuchiya K, Nakamura T, Ohtsuka K, Okamoto R, Watanabe M
- Organizer
  ECCO2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221307
[Presentation] TP53 mutation in human colonic organoids acquires resistance to in vitro long-term inflammation.2019
- Author(s)
  Tsuchiya K, Watanabe S, Shirasaki T, Nishimura R, Katsukura N, Hibiya S, Okamoto R, Nakamura T, Watanabe M
- Organizer
  ECCO2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221307
[Presentation] Human colonic organoid treated with inflammatory factors might mimic the pathophysiology of epithelial cells in ulcerative colitis.2018
- Author(s)
  Hibiya S, Tsuchiya K, Watanabe S, Nishimura R, Shirasaki T, Oshima S, Okamoto R, Nakamura T, Watanabe M
- Organizer
  DDW 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02791
[Presentation] Identification of lesion-specific epithelial function of ulcerative colitis by comparing colonic organoids from lesion and non-lesion parts of same patients.2018
- Author(s)
  Shirasaki T, Tsuchiya K, Nishimura R, Watanabe S, Hibiya S, Katsukura N, Okamoto R, Nakamura T, Watanabe M
- Organizer
  DDW 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221307
[Presentation] Human colonic organoid treated with inflammatory factors might mimic the pathophysiology of epithelial cells in ulcerative colitis.2018
- Author(s)
  Hibiya S, Tsuchiya K, Watanabe S, Nishimura R, Shirasaki T, Oshima S, Okamoto R, Nakamura T, Watanabe M
- Organizer
  DDW 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221307
[Presentation] Identification of lesion-specific epithelial function of ulcerative colitis by comparing colonic organoids from lesion and non-lesion parts of same patients.2018
- Author(s)
  Shirasaki T, Tsuchiya K, Nishimura R, Watanabe S, Hibiya S, Katsukura N, Okamoto R, Nakamura T, Watanabe M
- Organizer
  DDW 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19535
[Presentation] Lesion-specific gene expression in the Epithelial cells of Crohn’s disease by comparing Small intestinal organoids from active and inactive Lesion in the same patient.2018
- Author(s)
  Hibiya S, Tsuchiya K, Nishimura R, Shirasaki T, Watanabe S, Katsukura N, Okamoto R, Nakamura T, Watanabe M
- Organizer
  UEGW 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221307
[Presentation] Identification of lesion-specific epithelial function of ulcerative colitis by comparing colonic organoids from lesion and non-lesion parts of same patients.2018
- Author(s)
  Shirasaki T, Tsuchiya K, Nishimura R, Watanabe S, Hibiya S, Katsukura N, Okamoto R, Nakamura T, Watanabe M
- Organizer
  DDW 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02791
[Presentation] Long-lived secretory cells residing in the mouse proximal colon serve as reserve stem cells under DNA damage-induced mucosal injury.2018
- Author(s)
  Kuwabara K, Ishibashi F, Kawamoto A, Anzai S, Takahashi J, Nagata S, Shimizu H, Yui S, Oshima S, Tsuchiya K, Nakamura T, Watanabe M, Okamoto R
- Organizer
  UEGW 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221307
[Presentation] Tp53 mutation enhances cell proliferation and stemness in human colon epithelial organoids and promotes a resistance against long-term inflammation.2018
- Author(s)
  Watanabe S, Tsuchiya K, Shirasaki T, Hibiya S, Nishimura S, Katsukura N, Oshima S, Okamoto R, Tetsuya N, Watanabe M
- Organizer
  UEGW 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02791
[Presentation] Tp53 mutation enhances cell proliferation and stemness in human colon epithelial organoids and promotes a resistance against long-term inflammation.2018
- Author(s)
  Watanabe S, Tsuchiya K, Shirasaki T, Hibiya S, Nishimura S, Katsukura N, Oshima S, Okamoto R, Tetsuya N, Watanabe M
- Organizer
  UEGW 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221307
[Presentation] Lesion-specific gene expression in the Epithelial cells of Crohn’s disease by comparing Small intestinal organoids from active and inactive Lesion in the same patient.2018
- Author(s)
  Hibiya S, Tsuchiya K, Nishimura R, Shirasaki T, Watanabe S, Katsukura N, Okamoto R, Nakamura T, Watanabe M
- Organizer
  UEGW 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02791
[Presentation] Single-cell level analysis of organoids derived from CD patients reveals disease-status related modifications of small intestinal stem cells.2018
- Author(s)
  Suzuki K, Kuwabara K, Takahashi J, Anzai S, Kuno R, Kawamoto A, Ishibashi F, Nagata S, Hiraguri Y, Yui S, Tsuchiya K, Nakamura T, Ohtsuka K, Okamoto R, Watanabe M
- Organizer
  DDW 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221307
[Presentation] Ectopic expression of reg3a in the mice distal Colon is mediated by interactions between notch and Il-22 signaling pathways, and promotes tissue repair By the augmentation of EGFR signaling.2018
- Author(s)
  Ishibashi F, Kuwabara K, Kawamoto A, Anzai S, Takahashi J, Nagata S, Shimizu H, Yui S, Oshima S, Tsuchiya K, Nakamura T, Watanabe M, Okamoto R
- Organizer
  UEGW 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221307
[Presentation] Crohn’s disease patient-derived small intestinal organoids reveal diseasestatus related modification of stem cell properties.2018
- Author(s)
  Suzuki K, Takahashi J, Hiraguri Y, Yui S, Shimizu H, Tsuchiya K, Nakamura T, Ohtsuka K, Okamoto R, Watanabe M
- Organizer
  5th TERMIS World Congress 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221307
[Presentation] Fetalization of colonic epithelium medicated by YAP/TAZ links ECM remodeling to tissue regeneration.2018
- Author(s)
  Yui S, Okamoto R, Tsuchiya K, Nakamura T, Watanabe M
- Organizer
  GI Research Academy2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221307
[Presentation] Crohn’s disease patient-derived small intestinal organoids reveal disease-status related modification of stem cell properties. 52018
- Author(s)
  Suzuki K, Murano T, Hiraguri Y, Takahashi J, Shimizu H,Anzai S, Kuwabara K, Kawamoto A, Ishibashi F, Yui S, Tsuchiya K, Nakamura T, Ohtsuka K, Watanabe M, Okamoto R
- Organizer
  5th TERMIS World Congress 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221307
[Presentation] Mouse colonic secretory cells de-differentiate into intestinal stem cells and promote mucosal repair through activation of NF-KB signaling.2018
- Author(s)
  Ishibashi F, Shimizu H, Kawamoto A, Suzuki K, Anzai S, Kuwabara K, Takahashi J, Nagata S, Oshima S, Tsuchiya K, Nakamura T, Watanabe M, Okamoto R
- Organizer
  ISSCR2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221307
[Presentation] Lesion-specific gene expression in the Epithelial cells of Crohn’s disease by comparing Small intestinal organoids from active and inactive Lesion in the same patient.2018
- Author(s)
  Hibiya S, Tsuchiya K, Nishimura R, Shirasaki T, Watanabe S, Katsukura N, Okamoto R, Nakamura T, Watanabe M
- Organizer
  UEGW 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19535
[Presentation] The identification of lesion-specific gene expression in intestinal epithelial cells of Ulcerative Colitis by comparing colonic organoids from lesion and non-lesion parts of same patients.2018
- Author(s)
  Nishimura R, Tsuchiya K, Shirasaki T, Watanabe S, Hibiya S, Okamoto R, Nakamura T, Watanabe M
- Organizer
  The 13th Congress of ECCO
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221307
[Presentation] 消化管幹細胞研究の最前線2017
- Author(s)
  土屋輝一郎
- Organizer
  第13回日本消化管学会総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2017-03-17
- Invited
- Data Source
  KAKENHI-PROJECT-15K15287
[Presentation] Atoh1 protein stability in sporadic colon cancer and colitis-associated cancer2017
- Author(s)
  Tsuchiya K
- Organizer
  BIT’s 10th Anniversary of Protein & Peptide Conference-2017
- Place of Presentation
  Hilton Fukuoka Sea Hawk（Japan）
- Year and Date
  2017-03-22
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04808
[Presentation] Reprogrammed Atoh1+ intestinal epithelial cells contribute to regenerate damaged colonic mucosa in DSS-induced colitis.2017
- Author(s)
  Ishibashi F, Shimizu H, Nakata T, Fujii S, Suzuki K, Kawamoto A, Anzai S, Kuno R, Nagata S, Ito G, Murano T, Oshima S, Tsuchiya K, Nakamura T, Okamoto R, Watanabe M
- Organizer
  UEGW2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221307
[Presentation] 炎症性腸疾患に付随するがんの病態解明2017
- Author(s)
  土屋　輝一郎、渡辺　守
- Organizer
  JDDW2017
- Data Source
  KAKENHI-PROJECT-15H04808
[Presentation] Lineage tracing reveals contribution of Atoh1+ cell-derived stem cells in the homeostasis, repair, and carcinogenesis of the intestinal epithelium2017
- Author(s)
  Ishibashi F, Shimizu H, Nakata T, Fujii S, Suzuki K, Kawamoto A, Anzai S, Kuno R, Nagata S, Ito G, Murano T, Oshima S, Tsuchiya K, Nakamura T, Okamoto R, Watanabe M
- Organizer
  DDW2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221307
[Presentation] Establishment of a colonic oranoid with Wnt-independent growth by long-term inflammatory stimulation.2017
- Author(s)
  Shuji Hibiya, Kiichiro Tsuchiya, Mamoru Watanabe
- Organizer
  第７６回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-15H04808
[Presentation] バルーン内視鏡生検検体を用いたクローン病病態解析.2017
- Author(s)
  土屋輝一郎、渡辺　守.
- Organizer
  第35回サイトプロテクション研究会
- Place of Presentation
  メルパルク京都（京都府京都市）
- Data Source
  KAKENHI-PROJECT-15H04808
[Presentation] TP53 mutation acquires higher malignant potential in human colon cancer cells2017
- Author(s)
  Watanabe S, Tsuchiya K, Shirasaki T, Hibiya S, Oshima S, Nakamura T, Nishimura R, Okamoto R, Watanabe M.
- Organizer
  UEGW2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04808
[Presentation] 消化管幹細胞研究の最前線.2017
- Author(s)
  土屋輝一郎
- Organizer
  第13回日本消化管学会総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2017-03-17
- Invited
- Data Source
  KAKENHI-PROJECT-15H04808
[Presentation] Mouse colonic organoid acquires wnt-independent survival property after long-term inflammation2016
- Author(s)
  Hibiya S, Tsuchiya K, Shirasaki T, Fukushima K, Oshima S, Okamoto R, Nakamura T, Watanabe M
- Organizer
  AOCC 2016
- Place of Presentation
  京都国際会議場（京都府・京都市)
- Year and Date
  2016-07-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221307
[Presentation] Mouse colonic organoid acquires wnt-independent survival property after long-term inflammation.2016
- Author(s)
  Shuji Hibiya, Kiichiro Tsuchiya, Tomoaki Shirasaki, Keita Fukushima, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe.
- Organizer
  AOCC2016
- Place of Presentation
  Kyoto International Conference Center, Kyoto（JAPAN）
- Year and Date
  2016-07-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04808
[Presentation] Stimulation with the ligands of toll like receptors in primary human organoids2016
- Author(s)
  Shirasaki T, Tsuchiya K, Hibiya S, Nishimura R, Watanabe S, Okamoto R, Nakamura T, Watanabe M
- Organizer
  AOCC 2016
- Place of Presentation
  京都国際会議場（京都府・京都市）
- Year and Date
  2016-07-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221307
[Presentation] Construction of In Vitro Model for Inflammatory Bowel Disease Using Primary Colonic Organoid2016
- Author(s)
  Hibiya S, Tsuchiya K, Shirasaki T, Fukushima K, Oshima S, Okamoto R, Nakamura T, Watanabe M
- Organizer
  DDW2016
- Place of Presentation
  サンディエゴ（アメリカ）
- Year and Date
  2016-05-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221307
[Presentation] ATOH1 Protein Stabilization in Tumor Acquires the Morphological Change to Signet Ring Cell Carcinoma With Cancer Stem Cell Enrichment in Colon Cancer.2016
- Author(s)
  Tsuchiya K, Hibiya S, Fukushima K, Shirasaki T, Okamoto R, Nakamura T, Watanabe M
- Organizer
  DDW2016
- Place of Presentation
  サンディエゴ（アメリカ）
- Year and Date
  2016-05-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221307
[Presentation] 長期炎症刺激による大腸上皮培養細胞の非可逆的NF κB シグナル活性.2016
- Author(s)
  日比谷秀爾、土屋輝一郎、白崎友彬、福島啓太、大島　茂、岡本隆一、中村哲也、渡辺　守.
- Organizer
  第102回日本消化器病学会総会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-15H04808
[Presentation] 炎症関連大腸がんにおけるがん幹細胞形質獲得機構2016
- Author(s)
  土屋　輝一郎
- Organizer
  日本がん分子標的治療学会第11回トランスレーショナルリサーチワークショップ
- Place of Presentation
  都市センターホテル（東京都千代田区）
- Year and Date
  2016-01-15
- Invited
- Data Source
  KAKENHI-PROJECT-15H04808
[Presentation] Construction of in vitro model for inflammatory bowel disease using primary colonic organoid.2016
- Author(s)
  Syuji Hibiya, Kiichiro Tsuchiya, Tomoaki Shirasaki, Keita Fukushima, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe.
- Organizer
  DDW2016
- Place of Presentation
  San Diego（USA）
- Year and Date
  2016-05-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04808
[Presentation] Jagged1 is Indispensable for the Maintenance of Tumor Stem Cell Niche in APC-Deficient Intestinal Adenomas2016
- Author(s)
  Nakata T, Ito G, Shimizu H, Fujii S, Suzuki K, Ishibashi F, Kawamoto A, Tsuchiya K, Nakamura T, Hozumi K, Okamoto R, Watanabe M
- Organizer
  DDW2016
- Place of Presentation
  サンディエゴ（アメリカ）
- Year and Date
  2016-05-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221307
[Presentation] 小腸内視鏡生検検体を用いたクローン病におけるα defensin 発現解析.2016
- Author(s)
  林　亮平、土屋輝一郎、渡辺　守.
- Organizer
  第102回日本消化器病学会総会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-15H04808
[Presentation] OLFM4 and UBD are up-regulated in the inflamed intestinal epithelia of IBD patients by synergy of Notch signaling and TNF-α2016
- Author(s)
  Kawamoto A, Ito G, Nakata T, Fujii S, Suzuki K, Ishibashi F, Shimizu H, Tsuchiya K, Nakamura T, Okamoto R, Watanabe M
- Organizer
  AOCC 2016
- Place of Presentation
  京都国際会議場（京都府・京都市)
- Year and Date
  2016-07-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221307
[Presentation] Atoh1 protein stabilization in colon tumor acquires the　morphological change to signet ring cell carcinoma with cancer stem cell　enrichment.2016
- Author(s)
  Tsuchiya K, Hibiya S, Fukushima K, Shirasaki T, Oshima S, Okamoto R, Nakamura T, Watanabe M
- Organizer
  APDW2016
- Place of Presentation
  神戸国際会議場（兵庫県・神戸市）
- Year and Date
  2016-11-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221307
[Presentation] Single-Cell Level Analysis Reveals Heterogeneous Expression of Stem-Cell Specific Genes in Human Small Intestinal Organoids2016
- Author(s)
  Suzuki K, Fujii S, Kawamoto A, Ishibashi F, Nakata T, Ito G, Shimizu H, Tsuchiya K, Nakamura T, Ohtsuka K, Okamoto R, Watanabe M
- Organizer
  DDW2016
- Place of Presentation
  サンディエゴ（アメリカ）
- Year and Date
  2016-05-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221307
[Presentation] 炎症関連大腸がんにおけるがん幹細胞形質獲得機構2016
- Author(s)
  土屋　輝一郎
- Organizer
  日本がん分子標的治療学会第11回トランスレーショナルリサーチワークショップ
- Place of Presentation
  都市センターホテル（東京都千代田区）
- Year and Date
  2016-01-15
- Data Source
  KAKENHI-PROJECT-15K15287
[Presentation] 炎症性腸疾患関連大腸がんの形質獲得機構2016
- Author(s)
  土屋輝一郎
- Organizer
  お茶の水がん学アカデミア１２４回集会
- Place of Presentation
  順天堂大学（東京都文京区）
- Invited
- Data Source
  KAKENHI-PROJECT-15H04808
[Presentation] Construction of in vitro model of ulcerative colitis using mouse primary colonic organoid.2016
- Author(s)
  Hibiya S, Tsuchiya K, Watanabe S, Shirasaki T, Oshima S, Okamoto R, Nakamura T, Watanabe M.
- Organizer
  UEGW2016
- Place of Presentation
  Vienna（Austria）
- Year and Date
  2016-10-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04808
[Presentation] ヒトLgr5 発現可視化による粘液産生大腸癌ニッチ解析2016
- Author(s)
  福島啓太、土屋輝一郎、加納嘉人、白崎友彬、日比谷秀爾、岡本隆一、中村哲也、渡辺　守.
- Organizer
  第102回日本消化器病学会総会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-15H04808
[Presentation] Construction of in vitro model of ulcerative colitis using mouse primary colonic organoid2016
- Author(s)
  Hibiya S, Tsuchiya K, Watanabe S, Shirasaki T, Oshima S, Okamoto R, Nakamura T, Watanabe M
- Organizer
  UEGW2016
- Place of Presentation
  ウィーン（オーストリア）
- Year and Date
  2016-10-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221307
[Presentation] Atoh1 protein stabilization in colon tumor acquires the phenotype of signet ring cell carcinoma with cancer stem cell enrichment.2016
- Author(s)
  Kiichiro Tsuchiya, Shuji Hibiya, Keita Fukushima, Tomoaki Shirasaki, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe.
- Organizer
  AOCC2016
- Place of Presentation
  Kyoto International Conference Center, Kyoto（JAPAN）
- Year and Date
  2016-07-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04808
[Presentation] In Vitro organoid model reveals PGF2 as a Robust Mediator of chloride & water secretion bt human intestinal epithelial cells.2016
- Author(s)
  Fujii S, Suzuki K, Kawamoto A, Ishibashi F, Nakata T, Ito G, Shimizu H, Mizutani T, Tsuchiya K, Nakamura T, Ohtsuka K, Okamoto R, Watanabe M
- Organizer
  DDW2016
- Place of Presentation
  サンディエゴ（アメリカ）
- Year and Date
  2016-05-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221307
[Presentation] Atoh1 protein stabilization in colon tumor acquires the　morphological change to signet ring cell carcinoma with cancer stem cell enrichment.2016
- Author(s)
  Tsuchiya K, Hibiya S, Fukushima K, Shirasaki T, Oshima S, Okamoto R, Nakamura T, Watanabe M.
- Organizer
  APDW2016
- Place of Presentation
  Kobe convention center, KOBE（JAPAN）
- Year and Date
  2016-11-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04808
[Presentation] ATOH1 Protein stabillzation in tumor acquires the morphological change to signet ring cell enrichment in colon cancer.2016
- Author(s)
  Kiichiro Tsuchiya, Shuji Hibiya, Keita Fukushima, Tomoaki Shirasaki, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe.
- Organizer
  DDW2016
- Place of Presentation
  San Diego（USA）
- Year and Date
  2016-05-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04808
[Presentation] 生検検体が切り拓くIBD病態解明と臨床展開.2016
- Author(s)
  土屋輝一郎
- Organizer
  第14回広島消化器免疫研究会
- Place of Presentation
  ホテルグランヴィア広島（広島県広島市）
- Invited
- Data Source
  KAKENHI-PROJECT-15H04808
[Presentation] Stimulation with the ligands of Toll like receptors in primary human organoids.2016
- Author(s)
  Tomoaki Shirasaki, Kiichiro Tsuchiya, Shuji Hibiya, Ryu Nishimura, Keita Fukushima, Sho Watanabe, Ryuichi Okamoto, Tetsuya Nakamura and Mamoru Watanabe.
- Organizer
  AOCC2016
- Place of Presentation
  Kyoto International Conference Center, Kyoto（JAPAN）
- Year and Date
  2016-07-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04808
[Presentation] Distinct Role of Notch Ligands, DLL1 and Dll4, in Normal and in Tumor Intestinal Epithelium.2015
- Author(s)
  Toru Nakata, Hiromichi Shimizu, Kohei Suzuki, Satoru Fujii, Go Ito, Kiichiro Tsuchiya, Tetsuya Nakamura, Ryuichi Okamoto, Katsuto Hozumi, Mamoru Watanabe.
- Organizer
  DDW 2015
- Place of Presentation
  ワシントン（米国）
- Year and Date
  2015-05-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Mapping biopsy of entire small intestine is useful to assess the pathogenesis of Crohn’s disease.2015
- Author(s)
  Kiichiro Tsuchiya, Ryohei Hayashi Mamoru Watanabe
- Organizer
  AOCC2015
- Place of Presentation
  北京（中国）
- Year and Date
  2015-06-18
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04808
[Presentation] Notch Ligands DLL1 and Dll4 Are Expressed by Distinct Population of Epithelial Cells in the Mice Intestine.2015
- Author(s)
  Hiromichi Shimizu, Kohei Suzuki, Satoru Fujii, Toru Nakata, Go Ito, Tatsuro Murano, Kiichiro Tsuchiya, Tetsuya Nakamura, Ryuichi Okamoto, Katsuto Hozumi, Mamoru Watanabe.
- Organizer
  DDW 2015
- Place of Presentation
  ワシントン；米国
- Year and Date
  2015-05-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Mapping biopsy of entire small intestine is useful to assess the pathogenesis of Crohn’s disease.2015
- Author(s)
  Kiichiro Tsuchiya, Ryohei Hayashi Mamoru Watanabe
- Organizer
  AOCC2015
- Place of Presentation
  北京（中国）
- Year and Date
  2015-06-18
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15287
[Presentation] Contiuous stimulation with cytokines leads to irreversible activation of NF-kB signaling in colonic epithelial cells by organoid culture.2015
- Author(s)
  Shuji Hibiya, Kiichiro Tsuchiya, Tomoaki Shirasaki, Keita Fukushima, Ryohei Hayashi, Nobukatsu Horita, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, M. Watanabe
- Organizer
  UEGW2015.
- Place of Presentation
  Barcelona（Spain）
- Year and Date
  2015-10-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221307
[Presentation] Atoh1 protein stabilized by TNF-α acquires enhanced malignant potential in colitis-associated colorectal cancer.2015
- Author(s)
  Tomoaki Shirasaki, Keita Fukushima, Kiichiro Tsuchiya, Shuuji Hibiya, Ryohei Hayashi, Nobukatsu Horita, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe.
- Organizer
  AOCC2015
- Place of Presentation
  北京（中国）
- Year and Date
  2015-06-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Establishment of a 3D cell culture-based screening platform to identify natural products that can regulate transepithelial water transport of the human gastrointestinal tract.2015
- Author(s)
  Fujii Satoru, Okamoto Ryuichi, Nakata Toru, Suzuki Kohei, Ishibashi Fumiaki, Kawamoto Ami, Segawa Sayaka-Ohashi, Mizutani Tomohiro, Tsuchiya Kiichiro, Nakamura Tetsuya, Mamoru Watanabe
- Organizer
  Pacifichem2015
- Place of Presentation
  Hawaii（U.S.A.）
- Year and Date
  2015-12-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221307
[Presentation] Continuous Stimulation With Cytokines Leads to Irreversible Accumulation of NF-kB Signaling in Colonic Epithelial Cells.2015
- Author(s)
  Shuji Hibiya, Kiichiro Tsuchiya, Keita Fukushima, Ryohei Hayashi, Nobukatsu Horita, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, M. Watanabe
- Organizer
  DDW 2015
- Place of Presentation
  Washington,D.C.（U.S.A.）
- Year and Date
  2015-05-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221307
[Presentation] Continuous Stimulation With Cytokines Leads to Irreversible Accumulation of NF-kB Signaling in Colonic Epithelial Cells.2015
- Author(s)
  Shuji Hibiya, Kiichiro Tsuchiya, Keita Fukushima, Ryohei Hayashi, Nobukatsu Horita, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe.
- Organizer
  DDW 2015
- Place of Presentation
  ワシントン（米国）
- Year and Date
  2015-05-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] The Acquisition of Cancer Stemness by Atoh1 in Colitis Associated Cancer2015
- Author(s)
  Kiichiro Tsuchiya, Keita Fukushima, Mamoru Watanabe
- Organizer
  8th Annual World Congress of Regenerative Medicine & Stem Cells
- Place of Presentation
  釜山（韓国）
- Year and Date
  2015-03-21
- Invited
- Data Source
  KAKENHI-PUBLICLY-25130704
[Presentation] Acquisition of enhanced malignant potential in inflammation associated colon cancer2015
- Author(s)
  Kiichiro Tsuchiya, Shuji Hibiya, Mamoru Watanabe
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-10-08
- Invited
- Data Source
  KAKENHI-PROJECT-15K15287
[Presentation] Establishment of a 3D cell culture-based screening platform to identify natural products that can regulate transepithelial water transport of the human gastrointestinal tract.2015
- Author(s)
  Satoru Fujii, Ryuichi Okamoto, Toru Nakata, Kohei Suzuki, Fumiaki Ishibashi, Ami Kawamoto,Sayaka Ohashi Segawa, Tomohiro Mizutani, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe.
- Organizer
  Pacifichem2015
- Place of Presentation
  ハワイ（米国）
- Year and Date
  2015-12-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] A novel fluorescent labelling system into small intestinal organoid reveals independent long-lived intestinal stem cells in a crypt.2015
- Author(s)
  Nobuyuki Horita, Kiichiro Tsuchiya, Ryohei Hayashi, Keita Fukushima, Shuji Hibiya, Masayoshi Fukuda, Tomohiro Mizutani, Ryuichi Okamoto, Testuya Nakamura and M. Watanabe
- Organizer
  AOCC2015
- Place of Presentation
  北京（China）
- Year and Date
  2015-06-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221307
[Presentation] A novel fluorescent labelling system into small intestinal organoid reveals independent long-lived intestinal stem cells in a crypt.2015
- Author(s)
  Horita N,Tsuchiya K,Hayashi R,Fukushima K,Hibiya S,Fukuda M,Mizutani T,Okamoto R,Nakamura T and Watanabe M.
- Organizer
  AOCC2015
- Place of Presentation
  北京（中国）
- Year and Date
  2015-06-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Acquisition of enhanced malignant potential in inflammation associated colon cancer2015
- Author(s)
  Kiichiro Tsuchiya, Shuji Hibiya, Mamoru Watanabe
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-10-08
- Invited
- Data Source
  KAKENHI-PROJECT-15H04808
[Presentation] Mapping biopsy of entire small intestine revealed specific gene expression in Crohn’s disease2015
- Author(s)
  Kiichiro Tsuchiya, Ryohei Hayashi, Shuji Hibiya, Keita Fukushima, Nobukatsu Horita, Tomoaki Shirasaki, Eriko Okada, Akihiro Araki, Kazuo Ohtsuka, Mamoru Watanabe
- Organizer
  UEG Week 2015
- Place of Presentation
  バルセロナ（スペイン）
- Year and Date
  2015-10-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04808
[Presentation] Enrichment of Intestinal Stem Cells by the 3D-Culture of IBD Patient Derived Intestinal epithelium.2015
- Author(s)
  Kohei Suzuki,Satoru Fujii,Toru Nakata,Ami Kawamoto,Fumiaki Ishibashi,Sayaka Ohashi Segawa, Tomohiro Mizutani, Kiichiro Tsuchiya,Kazuo Otsuka,Tetsuya Nakamura,Ryuichi Okamoto,Mamoru Watanabe.
- Organizer
  AOCC2015
- Place of Presentation
  北京（中国）
- Year and Date
  2015-06-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Contiuous stimulation with cytokines leads to irreversible activation of NF-γb signaling in colonic epithelial cells by organoid culture.2015
- Author(s)
  Shuji Hibiya, Kiichiro Tsuchiya, Tomoaki Shirasaki, Keita Fukushima, Ryohei Hayashi, Nobukatsu Horita, Shigeru Oshima ,Ryuichi Okamoto, Tetsuya Nakamura,Mamoru Watanabe
- Organizer
  UEGW2015
- Place of Presentation
  バルセロナ（スペイン）
- Year and Date
  2015-10-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] TNF-α stabilizes atoh1 protein in colitis-associated colorectal cancer resulting in enhanced malignant potential.2015
- Author(s)
  Tomoaki Shirasaki, Keita Fukushima, Kiichiro Tsuchiya, Shuuji Hibiya, Ryohei Hayashi, Nobukatsu Horita, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe.
- Organizer
  UEGW2015
- Place of Presentation
  バルセロナ（スペイン）
- Year and Date
  2015-10-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Enrichment of Intestinal Stem Cells by the 3D-Culture of IBD Patient Derived Intestinal epithelium.2015
- Author(s)
  Kohei Suzuki, Satoru Fujii, Toru Nakata, Ami Kawamoto, Fumiaki Ishibashi, Sayaka Ohashi Segawa, Tomohiro Mizutani, Kiichiro Tsuchiya, Kazuo Otsuka,Tetsuya Nakamura, Ryuichi Okamoto, M. Watanabe
- Organizer
  DDW 2015
- Place of Presentation
  Washington,D.C.（U.S.A.）
- Year and Date
  2015-05-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221307
[Presentation] The Acquisition of Cancer Stemness by Atoh1 in Colitis Associated Cancer2015
- Author(s)
  Kiichiro Tsuchiya, Keita Fukushima, Mamoru Watanabe
- Organizer
  8th Annual World Congress of Regenerative Medicine & Stem Cells
- Place of Presentation
  釜山（韓国）
- Year and Date
  2015-03-21
- Invited
- Data Source
  KAKENHI-PROJECT-24590935
[Presentation] Atoh1 Protein Expression by TNF-a and the Acquisition of Malignant Potential in Colitis- Associated Colorectal Cancer.2015
- Author(s)
  Keita Fukushima, Kiichiro Tsuchiya, Shuji Hibiya, Ryohei Hayashi, Nobukatsu Horita, Yoshihito Kano, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe.
- Organizer
  DDW 2015
- Place of Presentation
  ワシントン（米国）
- Year and Date
  2015-05-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] The Acquisition of Cancer Stemness by Atoh1 in Colitis Associated Cancer2015
- Author(s)
  Kiichiro Tsuchiya, Keita Fukushima, Mamoru Watanabe
- Organizer
  8th Annual World Congress of Regenerative Medicine & Stem Cells
- Place of Presentation
  釜山（韓国）
- Year and Date
  2015-03-21
- Invited
- Data Source
  KAKENHI-PUBLICLY-25114703
[Presentation] Mapping biopsy of entire small intestine revealed specific gene expression in Crohn’s disease2015
- Author(s)
  Kiichiro Tsuchiya, Ryohei Hayashi, Shuji Hibiya, Keita Fukushima, Nobukatsu Horita, Tomoaki Shirasaki, Eriko Okada, Akihiro Araki, Kazuo Ohtsuka, Mamoru Watanabe
- Organizer
  UEG Week 2015
- Place of Presentation
  バルセロナ（スペイン）
- Year and Date
  2015-10-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15287
[Presentation] Human alpha-Defensin 6 regulated by the cooperation of beta-catenin and Atoh1, might be the pathogenesis of Crohn’s Disease.2015
- Author(s)
  Hayashi R, Tsuchiya K, Hibiya S, Fukushima K, Horita N, Okada E, Araki A, Ohtsuka K, Watanabe M
- Organizer
  Digestive Disease Week 2015
- Place of Presentation
  Washington D.C.（USA）
- Year and Date
  2015-05-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460945
[Presentation] Molecular mechanism in the pathogenesis of the colitis-associated colorectal cancer.2014
- Author(s)
  Tsuchiya K
- Organizer
  The 32th Annual Meeting of Japanese Society for Cytoprotection & Cytobiology
- Place of Presentation
  Kyoto, Japan
- Invited
- Data Source
  KAKENHI-PUBLICLY-25130704
[Presentation] Notch signaling and TNF-α synergistically up-regulates expression of OLFM4 in human intestinal epithelial cells.2014
- Author(s)
  Go Ito, Ryuichi Okamoto, Tasturo Murano, Hiromichi Shimizu, Satoru Fujii, Toru Nakata, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe .
- Organizer
  第8回Japan-US Collabaration Conference in Gastroenterology
- Place of Presentation
  Intercontinental TOKYO BAY (東京都港区海岸1-16-2)
- Year and Date
  2014-11-21
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Innate immune spiral of intestinal epithelial cells by the long-term inflammation.2014
- Author(s)
  Tsuchiya K, Hibiya S, Watanabe M:
- Organizer
  The 73rd Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  パシフィコ横浜（横浜）
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PUBLICLY-25114703
[Presentation] Notch signaling and TNF-α synergistically promotes intracellular protein expression of OLFM4 in human intestinal epithelial cells.2014
- Author(s)
  Go Ito, Ryuichi Okamoto, Hiromichi Shimizu, Satoru Fujii, Toru Nakata, Kohei Suzuki, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe.
- Organizer
  The 2nd Annual Meeting of Asian Organization for Crohn's and Colitis
- Place of Presentation
  Seoul (Korea)
- Year and Date
  2014-06-21
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Notch Signaling and TNF-alpha synergistically promotes intracellular protein accumulation of olfm4 in the inflamed mucosa of ulcerative colitis.2014
- Author(s)
  Go Ito, Ryuichi Okamoto, Hiromichi Shimizu, Satoru Fujii, Toru Nakata, Kohei Suzuki, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe.
- Organizer
  UEGW2014
- Place of Presentation
  Vienna (Austria)
- Year and Date
  2014-10-21
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Innate immune spiral of intestinal epithelial cells by the long-term inflammation.2014
- Author(s)
  Tsuchiya K, Hibiya S, Watanabe M
- Organizer
  The 73rd Annual Meeting of the Japanese Cancer Association.
- Place of Presentation
  パシフィコ横浜（横浜）
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PUBLICLY-25130704
[Presentation] Molecular mechanism in the pathogenesis of the colitis-associated colorectal cancer.2014
- Author(s)
  Tsuchiya K
- Organizer
  The 32th Annual Meeting of Japanese Society for Cytoprotection & Cytobiology
- Place of Presentation
  Kyoto, Japan
- Invited
- Data Source
  KAKENHI-PUBLICLY-25114703
[Presentation] Distinct Expression Patterns of Notch Ligands, DLL1 and DLL4, in Normal and Inflamed Mice Intestine.2014
- Author(s)
  Hiromichi Shimizu, Ryuichi Okamoto, Go Ito, Satoru Fujii, Toru Nakata, Kohei Suzuki, Tatsuro Murano, Tomohiro Mizutani, Kiichiro Tsuchiya, Tetsuya Nakamura, Katsuto Hozumi, Mamoru Watanabe.
- Organizer
  The 2nd Annual Meeting of Asian Organization for Crohn's and Colitis
- Place of Presentation
  Seoul (Korea)
- Year and Date
  2014-06-21
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Molecular mechanism in the pathogenesis of the colitis-associated colorectal cancer2014
- Author(s)
  Tsuchiya K
- Organizer
  The 32th Annual Meeting of Japanese Society for Cytoprotection & Cytobiology
- Place of Presentation
  Kyoto, Japan
- Invited
- Data Source
  KAKENHI-PROJECT-24590935
[Presentation] Innate immune spiral of intestinal epithelial cells by the long-term inflammation.2014
- Author(s)
  Tsuchiya K, Hibiya S, Watanabe M
- Organizer
  The 73rd Annual Meeting of the Japanese Cancer Association.
- Place of Presentation
  パシフィコ横浜（横浜）
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PROJECT-24590935
[Presentation] 消化管幹細胞と消化器癌幹細胞2013
- Author(s)
  土屋輝一郎
- Organizer
  第110回日本内科学会講演会.
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PUBLICLY-25130704
[Presentation] 全小腸マッピング生検検体を用いた網羅的遺伝子発現解析によるクローン病特異的遺伝子の同定2013
- Author(s)
  堀田伸勝、土屋輝一郎、渡辺守
- Organizer
  第85回日本消化器内視鏡学会総会
- Place of Presentation
  京都、京都国際会館
- Data Source
  KAKENHI-PUBLICLY-25114703
[Presentation] Cancer Stemness In Mucinous Colon Cancer.2013
- Author(s)
  Tsuchiya K, Kano Y, Watanabe M
- Organizer
  BIT's 6th Annual World Congress of Regenerative Medicine & Stem Cells-2013.
- Place of Presentation
  大連、中国
- Invited
- Data Source
  KAKENHI-PUBLICLY-25114703
[Presentation] Cancer Stemness In Mucinous Colon Cancer.2013
- Author(s)
  Tsuchiya K, Kano Y, Watanabe M
- Organizer
  BIT's 6th Annual World Congress of Regenerative Medicine & Stem Cells-2013.
- Place of Presentation
  大連、中国
- Invited
- Data Source
  KAKENHI-PUBLICLY-25130704
[Presentation] Atoh1 protein stabilization acquired cancer stem cell phenotype and niche in colon cancer2013
- Author(s)
  Kano Y, Tsuchiya K, Okamoto R, Nakamura T, Watanabe M
- Organizer
  GI Research Academy 2013
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24590935
[Presentation] 消化管幹細胞と消化器癌幹細胞2013
- Author(s)
  土屋輝一郎
- Organizer
  第110回日本内科学会講演会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-24590935
[Presentation] Atoh1発現大腸癌における幹細胞形質獲得とニッチ形成2013
- Author(s)
  加納嘉人、土屋輝一郎、渡辺守
- Organizer
  JDDW2013
- Place of Presentation
  東京
- Data Source
  KAKENHI-PUBLICLY-25130704
[Presentation] 炎症関連大腸がんにおける悪性形質獲得機構解析2013
- Author(s)
  土屋輝一郎
- Organizer
  がん研究分野の特性等を踏まえた支援活動公開シンポジウム
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-24590935
[Presentation] Live imaging of single cell reveals single stem cell dynamics in an organoid derived from murine small intestine2013
- Author(s)
  Horita N, Tsuchiya K, Hibiya S, Fukushima K, Kano Y, Xiu Zheng, Okamoto R, Nakamura T , Watanabe M
- Organizer
  DDW2013
- Place of Presentation
  Orland, USA
- Data Source
  KAKENHI-PUBLICLY-25114703
[Presentation] 白血球除去療法（LCAP）による潰瘍性大腸炎の治療戦略2013
- Author(s)
  土屋輝一郎
- Organizer
  JDDW2013
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PUBLICLY-25130704
[Presentation] Live imaging of single cell reveals single stem cell dynamics in an organoid derived from murine small intestine.2013
- Author(s)
  Horita N, Tsuchiya K, Hibiya S, Fukushima K, Kano Y, Xiu Zheng, Okamoto R, Nakamura T , Watanabe M
- Organizer
  DDW2013
- Place of Presentation
  Orland, USA
- Data Source
  KAKENHI-PROJECT-24590935
[Presentation] Atoh1発現大腸癌における幹細胞形質獲得とニッチ形成2013
- Author(s)
  加納嘉人、土屋輝一郎、渡辺守
- Organizer
  JDDW2013
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590935
[Presentation] Atoh1proteinstabilizationacquiredcancerstemcell phenotype and niche in colon cancer2013
- Author(s)
  Kano Y, Tsuchiya K, Watanabe M
- Organizer
  第72回日本癌学会学術集会
- Place of Presentation
  横浜、パシフィコ横浜
- Data Source
  KAKENHI-PUBLICLY-25114703
[Presentation] Atoh1proteinstabilizationacquiredcancerstemcell phenotype and niche in colon cancer.2013
- Author(s)
  Kano Y, Tsuchiya K, Watanabe M
- Organizer
  第72回日本癌学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PUBLICLY-25130704
[Presentation] Atoh1 protein stabilization acquired cancer stem cell phenotype and niche in colon cancer2013
- Author(s)
  Kano Y, Tsuchiya K, Okamoto R, Nakamura T: Watanabe M
- Organizer
  GI Research Academy 2013
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PUBLICLY-25130704
[Presentation] Stabilization of Atoh1 protein by TNF-α in colitic cancer might acquire the cancer stemness.DDW20132013
- Author(s)
  Tsuchiya K, Fukushima K, Kano Y, Hibiya S, Horita N, Xiu Zheng, Okamoto R,Nakamura T, Watanabe M
- Organizer
  DDW2013
- Place of Presentation
  Orland,USA
- Data Source
  KAKENHI-PUBLICLY-25130704
[Presentation] 白血球除去療法（LCAP）による潰瘍性大腸炎の治療戦略2013
- Author(s)
  土屋輝一郎
- Organizer
  JDDW2013
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PUBLICLY-25114703
[Presentation] 炎症関連大腸がんにおける悪性形質獲得機構解析2013
- Author(s)
  土屋輝一郎
- Organizer
  がん研究分野の特性等を踏まえた支援活動公開シンポジウム.
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PUBLICLY-25130704
[Presentation] Atoh1proteinstabilizationacquiredcancerstemcell phenotype and niche in colon cancer.2013
- Author(s)
  Kano Y, Tsuchiya K, Watanabe M
- Organizer
  第72回日本癌学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24590935
[Presentation] Cancer Stemness In Mucinous Colon Cancer.2013
- Author(s)
  Tsuchiya K, Kano Y, Watanabe M
- Organizer
  BIT's 6th Annual World Congress of Regenerative Medicine & Stem Cells-2013
- Place of Presentation
  大連、中国
- Invited
- Data Source
  KAKENHI-PROJECT-24590935
[Presentation] 全小腸マッピング生検検体を用いた網羅的遺伝子発現解析によるクローン病特異的遺伝子の同定2013
- Author(s)
  堀田伸勝、土屋輝一郎、渡辺守
- Organizer
  第85回日本消化器内視鏡学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24590935
[Presentation] 全小腸マッピング生検検体を用いた網羅的遺伝子発現解析によるクローン病特異的遺伝子の同定2013
- Author(s)
  堀田伸勝、土屋輝一郎、渡辺守
- Organizer
  第85回日本消化器内視鏡学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PUBLICLY-25130704
[Presentation] Live imaging of single cell reveals single stem cell dynamics in an organoid derived from murine small intestine.2013
- Author(s)
  Horita N, Tsuchiya K, Hibiya S, Fukushima K, Kano Y, Xiu Zheng, Okamoto R, Nakamura T , Watanabe M
- Organizer
  DDW2013
- Place of Presentation
  Orland,USA
- Data Source
  KAKENHI-PUBLICLY-25130704
[Presentation] Atoh1 protein stabilization acquired cancer stem cell phenotype and niche in colon cancer2013
- Author(s)
  Kano Y, Tsuchiya K, Okamoto R, Nakamura T: Watanabe M
- Organizer
  GI Research Academy
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PUBLICLY-25114703
[Presentation] NSAIDs服用患者における全長小腸粘膜の病理学的検討2013
- Author(s)
  岡田英理子、土屋輝一郎、岩嵜美智子、堀田伸勝、福島啓太、日比谷秀爾、加納嘉人、大塚和朗、荒木昭博、渡辺　守
- Organizer
  第85回日本消化器内視鏡学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-25460945
[Presentation] 全小腸マッピング生検によるクローン病病態解析2013
- Author(s)
  土屋輝一郎、堀田伸勝、林　亮平、日比谷秀爾、福島啓太、加納嘉人、渡辺　守
- Organizer
  第51回小腸研究会
- Place of Presentation
  名古屋、名古屋国際会議場
- Data Source
  KAKENHI-PUBLICLY-25114703
[Presentation] 炎症関連大腸がんにおける悪性形質獲得機構解析2013
- Author(s)
  土屋輝一郎
- Organizer
  がん研究分野の特性等を踏まえた支援活動公開シンポジウム.
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PUBLICLY-25114703
[Presentation] Stabilization of Atoh1 protein by TNF-α in colitic cancer might acquire the cancer stemness2013
- Author(s)
  Tsuchiya K, Fukushima K, Kano Y, Hibiya S, Horita N, Xiu Zheng, Okamoto R,Nakamura T, Watanabe M
- Organizer
  DDW2013
- Place of Presentation
  Orland, USA
- Data Source
  KAKENHI-PROJECT-24590935
[Presentation] 白血球除去療法（LCAP）による潰瘍性大腸炎の治療戦略2013
- Author(s)
  土屋輝一郎
- Organizer
  JDDW2013
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-24590935
[Presentation] Atoh1発現大腸癌における幹細胞形質獲得とニッチ形成2013
- Author(s)
  加納嘉人、土屋輝一郎、渡辺守
- Organizer
  JDDW2013
- Place of Presentation
  東京
- Data Source
  KAKENHI-PUBLICLY-25114703
[Presentation] 全小腸マッピング生検によるクローン病病態解析2013
- Author(s)
  土屋輝一郎、堀田伸勝、林　亮平、日比谷秀爾、福島啓太、加納嘉人、渡辺　守
- Organizer
  第51回小腸研究会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24590935
[Presentation] Stabilization of Atoh1 protein by TNF-α in colitic cancer might acquire the cancer stemness.DDW20132013
- Author(s)
  Tsuchiya K, Fukushima K, Kano Y, Hibiya S, Horita N, Xiu Zheng, Okamoto R,Nakamura T, Watanabe M
- Organizer
  DDW2013
- Place of Presentation
  Orland, USA
- Data Source
  KAKENHI-PUBLICLY-25114703
[Presentation] 消化管幹細胞と消化器癌幹細胞2013
- Author(s)
  土屋輝一郎
- Organizer
  第110回日本内科学会講演会
- Place of Presentation
  東京、東京国際フォーラム
- Invited
- Data Source
  KAKENHI-PUBLICLY-25114703
[Presentation] 全小腸マッピング生検によるクローン病病態解析2013
- Author(s)
  土屋輝一郎、堀田伸勝、林　亮平、日比谷秀爾、福島啓太、加納嘉人、渡辺　守
- Organizer
  第51回小腸研究会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PUBLICLY-25130704
[Presentation] The stabilization of Atoh1 protein in colon cancer acquires cancer stemness and chemoresistance.2012
- Author(s)
  Tsuchiya K, Kano Y, Mizutani T, Yui S, Nakamura T, Watanabe M
- Organizer
  第10回幹細胞シンポジウム
- Place of Presentation
  淡路島
- Data Source
  KAKENHI-PUBLICLY-23130506
[Presentation] Flagellin response via TLR5 on basolateral membrane of primary intestinal epithelial cells is regulated by Notch signaling.2012
- Author(s)
  Tsuchiya K, Zheng X, Kano Y, Okamoto R, Nakamura T, Watanabe M
- Organizer
  DDW2012
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-24590935
[Presentation] 大腸における幹細胞維持とがん幹細胞発現機構2012
- Author(s)
  土屋輝一郎、加納嘉人、中村哲也、渡辺守
- Organizer
  第44回日本臨床分子形態学会総会・学術集会
- Place of Presentation
  高知
- Invited
- Data Source
  KAKENHI-PUBLICLY-23130506
[Presentation] The stabilization of Atoh1 protein in colon cancer acquires cancer stemness and chemoresistance.2012
- Author(s)
  Tsuchiya K, Kano Y, Mizutani T, Yui S, Nakamura T, Watanabe M
- Organizer
  第10回幹細胞シンポジウム.
- Place of Presentation
  淡路島
- Data Source
  KAKENHI-PROJECT-24590935
[Presentation] The acquisition of cancer stemness in colon cancer by the Atoh1 protein stabilization.2012
- Author(s)
  Kano Y, Tsuchiya K, Horita N, Zheng X, Okamoto R, Nakamura T, Watanabe M
- Organizer
  DDW2012
- Place of Presentation
  San Diego, USA
- Year and Date
  2012-05-19
- Data Source
  KAKENHI-PUBLICLY-23130506
[Presentation] Intestinal stem cells and cancer stem cells.2012
- Author(s)
  Tsuchiya K
- Organizer
  Cancer Stem Cell Symposium
- Place of Presentation
  福岡
- Invited
- Data Source
  KAKENHI-PUBLICLY-23130506
[Presentation] 大腸における幹細胞維持とがん幹細胞発現機構2012
- Author(s)
  土屋輝一郎、加納嘉人、中村哲也、渡辺守
- Organizer
  第44回日本臨床分子形態学会総会・学術集会
- Place of Presentation
  高知
- Invited
- Data Source
  KAKENHI-PROJECT-24590935
[Presentation] Intestinal stem cells and cancer stem cells.2012
- Author(s)
  Tsuchiya K
- Organizer
  Cancer Stem Cell Symposium
- Place of Presentation
  福岡
- Invited
- Data Source
  KAKENHI-PROJECT-24590935
[Presentation] The stabilization of Atoh1 protein in colitic cancer induces cancer stemness and chemoresistance.2012
- Author(s)
  Tsuchiya K, Kano Y, Watanabe M
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24590935
[Presentation] The stabilization of Atoh1 protein in colitic cancer induces cancer stemness and chemoresistance.2012
- Author(s)
  Tsuchiya K, Kano Y, Watanabe M
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PUBLICLY-23130506
[Presentation] The acquisition of cancer stemness in colon cancer by the Atoh1 protein stabilization.2012
- Author(s)
  Kano Y, Tsuchiya K, Horita N, Zheng X, Okamoto R, Nakamura T, Watanabe M
- Organizer
  DDW2012
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-24590935
[Presentation] Flagellin response via TLR5 on basolateral membrane of primary intestinal epithelial cells is regulated by Notch signaling.2012
- Author(s)
  Tsuchiya K, Zheng X, Kano Y, Okamoto R, Nakamura T, Watanabe M
- Organizer
  DDW2012
- Place of Presentation
  San Diego, USA
- Year and Date
  2012-05-19
- Data Source
  KAKENHI-PUBLICLY-23130506
[Presentation] The stabilization of Atoh1 protein in colorectal cancer mimics raucinous adenocarcinoma2011
- Author(s)
  土屋輝一郎
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PUBLICLY-23130506
[Presentation] Cdx2 and Hes1 regulate Hath1 gene expression independently of each other, associating with goblet cell content in Ulcerative Colitis2011
- Author(s)
  Zheng X, Tsuchiya K
- Organizer
  DDW 2011
- Place of Presentation
  Chicago
- Year and Date
  2011-05-09
- Data Source
  KAKENHI-PUBLICLY-23130506
[Presentation] Flagellin via TLR5 on basolateral membrane of primary intestinal epithelial cells. (IEC) shows the role of IEC in the response to bacteria2011
- Author(s)
  Tsuchiya K
- Organizer
  UEGW2011
- Place of Presentation
  Stockholm
- Year and Date
  2011-10-26
- Data Source
  KAKENHI-PUBLICLY-23130506
[Presentation] IBDにおける消化管上皮の分化制御と免疫応答2011
- Author(s)
  土屋輝一郎
- Organizer
  第39回日本臨床免疫学会総会
- Place of Presentation
  東京(招待講演)
- Year and Date
  2011-09-17
- Data Source
  KAKENHI-PUBLICLY-23130506
[Presentation] The contribution of Atoh1/Hath1 to phenotypic gene expression for Paneth cells.2010
- Author(s)
  Tsuchiya K, Okamoto R, Watanabe M
- Organizer
  DDW2010
- Place of Presentation
  New Orleans
- Year and Date
  2010-05-05
- Data Source
  KAKENHI-PROJECT-21790653
[Presentation] Hes1 via Notch signaling directly suppresses Atoh1/Hath1 gene transcription, resulting in the goblet cell depletion of Ulcerative Colitis.2010
- Author(s)
  Xiu Zheng, Tsuchiya K, Watanabe M
- Organizer
  DDW2010
- Place of Presentation
  New Orleans.
- Year and Date
  2010-05-05
- Data Source
  KAKENHI-PROJECT-21790653
[Presentation] Silencing of Atoh1 gene expression by Hes1 via Notch signaling results in the goblet cell depletion of Ulcerative Colitis.2010
- Author(s)
  Tsuchiya K, Okamoto R, Watanabe M
- Organizer
  14th International Congress of Immunology.
- Place of Presentation
  Kobe.
- Year and Date
  2010-09-25
- Data Source
  KAKENHI-PROJECT-21790653
[Presentation] The contribution of Atoh1/Hath1 to phenotypic gene expression for Paneth cells.2010
- Author(s)
  Tsuchiya K, Okamoto R, Watanabe M
- Organizer
  DDW2010.
- Place of Presentation
  New Orleans.
- Year and Date
  2010-05-05
- Data Source
  KAKENHI-PROJECT-21790653
[Presentation] ダブルバルーン内視鏡による全小腸マッピング生検の有用性2010
- Author(s)
  土屋輝一郎、岩嵜美智子、鄭秀、岡本英子、加納嘉人、岡本隆一、中村哲也、荒木昭博、渡辺守
- Organizer
  第28回大腸検査学会総会
- Place of Presentation
  東京
- Year and Date
  2010-11-28
- Data Source
  KAKENHI-PROJECT-22590694
[Presentation] Colon carcinogenesis is divided in the undifferentiation and proliferation regulated by Atoh1 and beta-catenin on Wnt signaling, respectively2009
- Author(s)
  Tsuchiya K, et al.
- Organizer
  GASTRO2009
- Place of Presentation
  London
- Year and Date
  2009-11-23
- Data Source
  KAKENHI-PROJECT-21790653
[Presentation] Colon carcinogenesis is divided in the undifferentiation and proliferation regulated by Atoh1 and beta-catenin on Wnt signaling, respectively.2009
- Author(s)
  Tsuchiya K, Okamoto R, Watanabe M
- Organizer
  UEGW2009.
- Place of Presentation
  London.
- Year and Date
  2009-11-23
- Data Source
  KAKENHI-PROJECT-21790653
[Presentation] GSK3 inhibitor induces the intestinal differentiation by the protein stabilization of Atoh12009
- Author(s)
  Tsuchiya K, et al.
- Organizer
  DDW2009
- Place of Presentation
  Chicago
- Year and Date
  2009-06-02
- Data Source
  KAKENHI-PROJECT-21790653
[Presentation] GSK3 inhibitor induces the intestinal differentiation by the protein stabilization of Atoh12009
- Author(s)
  Tsuchiya K, Okamoto R, Nakamura T, Watanabe M
- Organizer
  DDW2009
- Place of Presentation
  Chicago
- Year and Date
  2009-06-02
- Data Source
  KAKENHI-PROJECT-19209027
[Presentation] GSK3 inhibitor induces the intestinal differentiation by the protein stabilization of Atohl.2009
- Author(s)
  Tsuchiya K, Watanabe M, et al.
- Organizer
  DDW2009
- Place of Presentation
  Chicago
- Year and Date
  2009-06-02
- Data Source
  KAKENHI-PROJECT-19209027
[Presentation] Notch Signaling suppresses the transcriptional activity of Hathl gene. resulting in the undifferentiated form of human intestinal epithelial cells.2008
- Author(s)
  Tsuchiya K
- Organizer
  DDW2008
- Place of Presentation
  San Diego (U. S. A)
- Year and Date
  2008-05-20
- Data Source
  KAKENHI-PROJECT-19590717
[Presentation] Notch signaling suppresses the transcriptional activity of Hath1 Gene, resulting in the undifferentiated form of human intestinal epithelial cells2008
- Author(s)
  Tsuchiya K, Inoue K, Aragaki M, Okamoto R, Nakamura T, Kanai T, Watanabe M
- Organizer
  DDW2008
- Place of Presentation
  San Diego
- Year and Date
  2008-05-20
- Data Source
  KAKENHI-PROJECT-19209027
[Presentation] Dysregulated differentiation of intestinal epithelia in UC2008
- Author(s)
  Okamoto R, Tsuchiya K, Nakamura T, Kanai T, Watanabe M
- Organizer
  3rd Japan-Korea IBD Symposium
- Place of Presentation
  Korea(Seoul)
- Year and Date
  2008-09-20
- Data Source
  KAKENHI-PROJECT-19590717
[Presentation] Notch signaling suppresses the transcriptional activity of Hath1 Gene, resulting in the undifferentiated form of human intestinal epithelial cells.2008
- Author(s)
  Tsuchiya K, Watanabe M
- Organizer
  DDW 2008
- Place of Presentation
  San Diego
- Year and Date
  2008-05-20
- Data Source
  KAKENHI-PROJECT-19209027
[Presentation] Notch signaling suppresses the transcriptional activity of Hath1 Gene, resulting in the undifferentiated form of human intestinal epithelial cells2008
- Author(s)
  Tsuchiya K, Inoue K, Aragaki M, Okamoto R, Nakamura T, Kanai T, Watanabe M
- Organizer
  DDW 2008
- Place of Presentation
  San Diego
- Year and Date
  2008-05-20
- Data Source
  KAKENHI-PROJECT-19590717
[Presentation] Novel Wnt signaling pathway targeting Hathl protein in inverse regulation to β-catenin, suppresses differentiation potency in human colon cancer.2007
- Author(s)
  Tsuchiya K
- Organizer
  APDW 2007.
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19590717
[Presentation] Stabilization of Atohl protein induces Mucin2 gene expression in human colon cancer cells.2007
- Author(s)
  Tsuchiya K
- Organizer
  DDW 2007.
- Place of Presentation
  Washington, D.C
- Year and Date
  2007-05-23
- Data Source
  KAKENHI-PROJECT-19590717
[Presentation] Activated notch signaling suppresses generation of goblet cells in the human intestinal mucosa2007
- Author(s)
  Okamoto R, Tsuchiya K, Kanai T, Watanabe M
- Organizer
  DDW 2007
- Place of Presentation
  Washington, D.C.
- Year and Date
  2007-05-20
- Data Source
  KAKENHI-PROJECT-19590717
[Presentation] Stabilization of Atoh1 protein induces Mucin2 gene expression in human colon cancer cells2007
- Author(s)
  Tsuchiya K, Okamoto R, Kanai T, Watanabe M
- Organizer
  DDW 2007
- Place of Presentation
  Washington, D.C.
- Year and Date
  2007-05-23
- Data Source
  KAKENHI-PROJECT-19590717
[Presentation] Stabilization of Atoh1 protein induces Mucin2 gene expression in human coloncancer cells.2007
- Author(s)
  Tsuchiya K, Watanabe M
- Organizer
  DDW 2007.
- Place of Presentation
  Washington, D.C
- Year and Date
  2007-05-23
- Data Source
  KAKENHI-PROJECT-19209027
[Presentation] IL-22-MEDIATED ANTIMICROBIAL RESPONSE IS REGULATED BY HES1 VIA STAT3-DEPENDENT TRANSCRIPTION IN HUMAN INTESTINAL EPITHELIAL CELLS
- Author(s)
  R. Okamoto, T. Murano, H. Shimizu, G. Ito, S. Fujii, T. Nakata, K. Tsuchiya, T. Nakamura, M. Watanabe
- Organizer
  UEGW 2013
- Place of Presentation
  ベルリン、ドイツ
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Complete conversion of crypt progenitor cells into Atoh1-positive cells by targeted deletion of Dll1 and Dll4 in Lgr5-positive intestinal stem cells
- Author(s)
  Hiromichi Shimizu, Ryuichi Okamoto, Satoru Fujii, Go Ito, Tatsuro Murano, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe
- Organizer
  DDW 2013
- Place of Presentation
  オーランド、米国
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Hes1 promotes IL-22-mediated antimicrobial response through enhancement of STAT3-dependent transcription in human intestinal epithelial cells
- Author(s)
  Ryuichi Okamoto, Tatsuro Murano, Hiromichi Shimizu, Go Ito, Satoru Fujii, Kiichiro Tsuchiya, Tetsuya Nakamura, and Mamoru Watanabe
- Organizer
  The 1st Annual Meeting of Asian Organization for Crohn's and Colitis
- Place of Presentation
  東京、ラフォーレ東京
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] LINEAGE-SPECIFIC EXPRESSION OF BESTROPHIN-2 AND BESTROPHIN-4 IS REGULATED BY NOTCH SIGNALING IN HUMAN INTESTINAL EPITHELIAL CELLS
- Author(s)
  G. Ito , R. Okamoto, T. Murano, H. Shimizu, K. Tsuchiya, T. Nakamura, M. Watanabe
- Organizer
  UEGW 2013
- Place of Presentation
  ベルリン、ドイツ
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] COMPLETE CONVERSION OF CRYPT PROGENITOR CELLS INTO ATOH1-POSITIVE CELLS BY TARGETED DELETION OF DLL1 AND DLL4 IN LGR5-POSITIVE INTESTINAL STEM CELLS
- Author(s)
  H. Shimizu, R. Okamoto, T. Nakata, S. Fujii, G. Ito, T. Murano, K. Tsuchiya, T. Nakamura, M. Watanabe
- Organizer
  UEGW 2013
- Place of Presentation
  ベルリン、ドイツ
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Notch signaling regulates expression of Bestrophin-4, a novel enterocyte-specific HCO3-/Cl- channel, in human intestinal epithelial cells.
- Author(s)
  Go Ito, Ryuichi Okamoto, Satoru Fujii, Hiromichi Shimizu, Tatsuro Murano, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe
- Organizer
  DDW 2013
- Place of Presentation
  オーランド、米国
- Data Source
  KAKENHI-PROJECT-25293170

1. WATANABE Mamoru (10175127)

# of Collaborated Projects: 20 results

# of Collaborated Products: 158 results
2. NAKAMURA Tetsuya (70265809)

# of Collaborated Projects: 4 results

# of Collaborated Products: 80 results
3. Ohtsuka Kazuo (00338443)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
4. HANDA Hiroshi (80107432)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. OKADA Eriko (20376784)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
6. ARAKI Akihiro (80361690)

# of Collaborated Projects: 3 results

# of Collaborated Products: 13 results
7. 大島茂 (50376787)

# of Collaborated Projects: 3 results

# of Collaborated Products: 19 results
8. NAGAISHI Takashi (60447464)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
9. FUKAO Taro (20401127)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
10. 柿沼晴 (30372444)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
11. TAKEDA Kiyoshi (20309446)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. Okamoto Ryuichi (50451935)

# of Collaborated Projects: 1 results

# of Collaborated Products: 46 results
13. KIYONO Hiroshi (10271032)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. KUBOTA Daisuke (00376790)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 八木田秀雄 (30182306)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 垣生園子 (30051618)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 油井史郎 (00383886)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 鬼澤道夫 (30783352)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
19. 赤星径一 (80749523)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 伴大輔 (40376736)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 小林正典 (10825459)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 竹中健人 (10783368)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. CHEN Cheng-hsin

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
24. HINOHARA Kunihiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. TAMURA Atsushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. HARA Takahiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. OSHIMA Hiroko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. NAKAYAMA Mizuho

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. SUZUKI Shinji

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
30. NAKADA Shinichiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. TOTSUKA Teruji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 金井隆典

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
33. 坂本直哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
34. 中川美奈

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
35. 後藤典子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 畠山鎮次

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 渡部昌

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. 伊川正人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
39. 月田早智子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
40. 笹月健彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
41. 時野隆至

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
42. 秋山好光

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
43. 田中真二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
44. 島田周

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
45. 佐々木泰史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
46. 深町博史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
47. 西村龍

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
48. 日比谷秀爾

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
49. 佐藤博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
50. 水谷知裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
51. 根本泰宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
52. 長堀正和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
53. 長沼誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
54. 藤井俊光

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
55. 烏山一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
56. 山西吉典

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
57. 大岡真也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
58. 櫻井幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
59. 佐藤俊朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
60. 森尾純子(秋山純子)

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
61. 荒瀬尚

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tsuchiya Kiichiro 土屋 輝一郎

TSUCHIYA Kiichirou 土屋 輝一郎

Research Projects

Research Products

Co-Researchers

ヒトクローン病モデル構築による粘膜治癒機構の解明Ongoing

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ヒト体外複合臓器モデルによる生体維持機構解析Ongoing

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ヒトiPS細胞由来胆管細胞培養系を用いた胆管癌における新規発癌機序の解明Ongoing

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腸上皮化生を主眼とした消化器がんのスキルス化機構に関する研究Principal InvestigatorOngoing

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炎症性腸疾患病変部に共通する特異的本態の解明Ongoing

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位置運命決定因子におけるヒト成体器官機能制御の解明Principal InvestigatorOngoing

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クローン病再燃予測システムの開発Ongoing

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Single cell imaging in human intestinal stem cellPrincipal Investigator

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Inflammation related carcinogenesis by spiral cell transformation using in vitro chronic colitis modelPrincipal Investigator

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腸管上皮細胞における自然免疫応答スパイラル機構解析Principal Investigator

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ヒト大腸上皮培養による大腸癌幹細胞の分化破綻機構解析Principal Investigator

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Tsuchiya Kiichiro 土屋輝一郎

TSUCHIYA Kiichirou 土屋輝一郎