Kiyono Hiroshi 清野宏

… Alternative Names

Researcher Number	10271032
Affiliation (Current)	2020: 東京大学, 医科学研究所, 特任教授
Affiliation (based on the past Project Information) *help	2018 – 2019: 東京大学, 医科学研究所, 特任教授 2002 – 2016: The Institute of Medical Science The University of Tokyo, Professor, 医科学研究所, 教授 2007: 東大, 医科学研究所, 教授 2005: Tokyo University, Graduate School of Medicine, Professor, 医学研究科, 教授 2004 – 2005: 東京大学, 医学系研究科, 教授 1995 – 2003: 大阪大学, 微生物病研究所, 教授 1998 – 2002: 大阪大学, 微生物研究所, 教授
Review Section/Research Field	Principal Investigator Biological Sciences / Immunology / Immunology / Medium-sized Section 53:Organ-based internal medicine and related fields / Broad Section I Except Principal Investigator Gastroenterology / 内科学一般 / Biological Sciences / Applied optics/Quantum optical engineering / Immunology … More
Keywords	Principal Investigator 粘膜免疫 / 粘膜ワクチン / IgA / 経鼻ワクチン / 分泌型IgA / 粘膜アジュバント / 経口ワクチン / 粘膜免疫調節因子 / AIDSワクチン / 経口免疫 … More Except Principal Investigator 粘膜免疫 / サイトカイン / 炎症性腸疾患 / IL-7 / 免疫病 / T細胞 / 転写因子 / 食物アレルギー / inflammatory bowel disease / HIV / CXCR4 / CTL / アポトーシス / シグナル伝達 / 自然免疫 / 疫学 / 免疫学 / パイエル板 / ILISPOT / IDIP / 蛍光色素 / 粘膜免疫機構 / cytokine / Fluorescent dye / 免疫検査 / Immunoassay / HIV-1 / AIDS / mucosal immunity / NALT / IgA / mucosal immune system / food allergy / Bacteroides vulgatus / HVJ-liposome / 腸管免疫 / 再生医療 / 腸管上皮細胞 / 骨髄細胞 / 慢性大腸炎 / regenerative medicine / intestinal epithelial cell / bone marrow cell / FTY720 / IL-10^<- / ->マウス / Th1 / Atoh1 / Hath1 / Wnt / Notch / エイズ / CD26 / HHV8 / Fas / CXCR-4 / ヒト免疫不全ウイルス / 免疫不全 / 細胞傷害性T細胞 / インターロイキン2 / インターロイキン8 / エイズリンパ腫 / 自己免疫疾患 / 慢性炎症 / 原発性免疫不全症 / 免疫寛容の破綻 / チロシンキナーゼ / 免疫病の修復 / 免疫不全症 / 自己免疫症患 / ケモカイン / 自己抗原 / Btk / GPIアンカー / PIG-V / Sema4A / sema6D / TLR / MyD88非依存症性経路 / gH-gL-gO / LANA / 感染症 / ヒトヘルペスウイルス6 / セマフォリン / Toll様レセプター / インターロイキン6 / ヒトヘルペルウイルス6 / CD40 / ヒトヘルペスウイルス / 感染免疫 / ノックアウトマウス / 早期誘導反応 / 後期適応免疫 / Helicobacter pylori / 免疫 / 感染宿主 / 人種差 / 遺伝子型 / H.pylori / 病理 / 消化器病学 / 生体防御 / 免疫応答 / 生体恒常性 / 自己認識 / 免疫制御 / 胸腺 / 自己免疫病 / 炎症 / がん / 免疫系自己 / 自己識別 / 免疫病態 / 自己寛容 / 免疫組織 / がん免疫 / 獲得免疫 / 免疫老化 / 白血病 / アナジー / G蛋白 / 自己免疫 / 小腸粘膜傷害 / NSAID / 樹状細胞 / ＮＳＡＩＤ / 小腸粘膜障害 / ＮＳＡＩＤｓ / CD103陽性樹状細胞 / NSAIDｓ / 免疫検査法 / 自動化 / パターン認識 / レーザー / バイオメディカル / ILISPOT法 / 抗原特異抗体 / 免疫担当細胞 / immunoassay / automation / pattern recognition / laser / 免疫寛容 / B細胞 / 発生工学 / ポリコ-ム遺伝子 / 水晶体特異的遺伝子発現 / 有機リン系農薬センサー / T cell / Immunological tolerance / B cell / Transgenics / Polycomb genes / Crystallin gene / Biosensor / Transcriptional factor / 自動化細胞計測 / 画像処理 / 含フッ素化合物 / 白色光レーザ / Automated measurement of cell / Cytokin / Image processing / Fluorine-containing compound / White light laser / CCR5 / SDF-1 / dendritic cells / mucosol immunity / gp120 / V3ループ / エイズワクチン / Pathophysiology / Immune response / AIDS Control / Chemokine / Chemokine Receptor / ワクチン / 経鼻免疫 / インフルエンザ菌 / 肺炎球菌 / RSウイルス / 鼻粘膜 / 中耳粘膜 / マウス / CD4^+T細胞 / P6 / Intranasal immunization / vaccine / Mucosal immune system / Haemophilus influenzae / Streptococcus pneumoniae / RS virue / 経口免疫 / 神経内分泌系 / 食物アレルギーモデルマウス / 上皮細胞間リンパ球 / 鶏卵アレルギー / 神経ペプチド / クリプトパッチ / 消化管アレルギー / 炎症性腸管障害 / 卵白アルブミン / ニューロペプチド / 好中球 / CD4_+T細胞 / 消化管粘膜障害 / 炎症性粘膜障害 / 経口免疫寛容 / 粘膜ワクチン / トランスジェニックマウス / oral immunization / neuroendocrine system / animal model for food allergy / intraepithelial lymphocyte / egg white allergy / TCRα鎖欠損マウス / 食餌抗原 / 成分栄養 / 腸内細菌叢 / TCR α- / - mice / elemental diet / enteric flora / 含フッ素置換基 / カラーセンタレーザ / 赤外スペクトル / 赤外ラマン分光 / 赤外吸収 / 炭素-フッ素結合 / Fluorine-containing substituent / Color-center laser / Infrared spectrum / Infrared Raman spectroscopy / Infrared absorption / Carbon-fluorine bond / NF-kB / デコイ型核酸 / HVJ-liposome法 / 神経因性疼痛 / 遺伝子導入 / ベクター / デコイ / 疼痛過敏 / NF-κB / decoy / heuropathic pain / IL-7レセプター / 植物アレルギー / 粘膜リンパ球 / 骨髄幹細胞 / IL-7 receptor / mucosal jmmunity / chronic cohtis / IL-10遺伝子欠損マウス / 大腸粘膜固有層リンパ球 / 腸間膜リンパ節 / 粘膜固有層 / FK506 / Interleukin-10 gene-deficient mice / Colonic lamina propria lymphocyte / Peyer's patch / Mesenteric lymph node / Lamina propria / 腸上皮細胞 / 細胞分化 / 慢性腸炎 / 消化管粘膜免疫 / 粘膜IL-7 / IL-7レセプター機構 / 腸管上皮細胞分化 / Interferon Regulatory Factor (IRF) / 骨髄細胞transdifferentiation / Il-7レセプター / cell differentiation / chronic colitis / transcriptional factor / IL-10ノックアウトマウス / Bcl-2トランスジェニックマウス / 腸管上皮 / 消化管上皮 / Inflammatory Bowel Disease / IL-10 knock out mouse / Bcl transgenic mouse / Intestinal epithelium / apoptosis / 再生医学 / トランスレーショナルリサーチ / 発生・分化 / Wntシグナル / Notchシグナル / 細胞内シグナル伝達 / ユビキチン-プロテアソーム / 腸管分化 / Hath-1 / Differentiation / Regenerative medicine / Translational research / Signal transduction Less

消化管の階層的粘膜支持連関システムによる粘膜防御機構の解明Principal InvestigatorOngoing
- Principal Investigator
  
  清野宏
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  The University of Tokyo
Multi Regulatory System for Gut Homeostasis and InflammationPrincipal InvestigatorOngoing
- Principal Investigator
  
  清野宏
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section I
- Research Institution
  The University of Tokyo
Immunological crosstalk between nasal and reproductive mucosal tissuePrincipal Investigator
- Principal Investigator
  
  Kiyono Hiroshi
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo
顎顔面免疫と生殖器免疫のクロストークPrincipal Investigator
- Principal Investigator
  
  清野宏
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo
Investigation of the role of mucosal inductive site and indigenous bacteria on the NSAID-induced enteropathy
- Principal Investigator
  
  IIJIMA Hideki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Analysis of antigen-uptake network at mucosal epithelial layerPrincipal Investigator
- Principal Investigator
  
  KIYONO Hiroshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo
Mucosal Immunology and self‐discriminationPrincipal Investigator
- Principal Investigator
  
  KIYONO Hiroshi
- Project Period (FY)
  2007 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Immunological Self Recognition and its Disorders
- Principal Investigator
  
  MINATO Nagahiro
- Project Period (FY)
  2007 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
生体防御と免疫病制御の統合的パラダイム
- Principal Investigator
  
  MINATO Nagahiro
- Project Period (FY)
  2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Kyoto University
粘膜免疫監視の場としてのGALT・NALTを介した免疫制御誘導の解明Principal Investigator
- Principal Investigator
  
  清野宏
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Identification of the crosstalk between Notch signaling and Wnt signaling in the differentiation of the intestinal epithelial cells.
- Principal Investigator
  
  WATANABE Mamoru
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
エイズ粘膜ワクチン開発へ向けて:HIV特異的分泌型IgA誘導システムの開発Principal Investigator
- Principal Investigator
  
  清野宏
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
粘膜免疫監視の場としてのGALT・NALTを介した免疫制御誘導の解明Principal Investigator
- Principal Investigator
  
  清野宏
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Regulation of Intestinal Mucosal Immunity in a Mouse Model on Inflammatory Bowel Disease
- Principal Investigator
  
  ITO Toshinori
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Osaka University
HIV特異的分泌型IgA誘導粘膜ワクチン開発へ向けての基礎研究Principal Investigator
- Principal Investigator
  
  清野宏
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Development of a novel therapy for the treatment of chronic colitis based on the manipulation of mucosal immune response and the clarification of tissue specific system for epithelial regeneration.
- Principal Investigator
  
  WATANABE Mamoru
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
粘膜ワクチンへの基礎研究:HIV特異的分泌型IgA誘導システムの開発Principal Investigator
- Principal Investigator
  
  清野宏
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
粘膜ワクチンへの基礎研究:HIV特異的分泌型IgA誘導型アジュバント開発Principal Investigator
- Principal Investigator
  
  清野宏
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Elucidation of the mechanism for regurating mucosal immune response and application for the treatment of chronic colitis and food allergy.
- Principal Investigator
  
  WATANABE Mamoru
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
Study of mucosal immune response in the murine model of inflammatory bowel disease -Therapeutic effect of a new immunosuppressive reagent FTY720-
- Principal Investigator
  
  ITO Toshinori
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Osaka University
H.pylori感染者の病型決定因子に関する集学的研究
- Principal Investigator
  
  若月芳雄
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  Kyoto University
Therapy of neuropathic pain by using a gene-based approach of NF-κB decoy
- Principal Investigator
  
  MASHIMO Takashi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Osaka University
免疫病とその修復
- Principal Investigator
  
  高津聖志
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokyo
Application of a color-center laser to an immunoassay using an IR-Raman spectroscopy technique.
- Principal Investigator
  
  KAMEMARU Shun-ichi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Applied optics/Quantum optical engineering
- Research Institution
  Kitami Institute of Technology
感染免疫の分子基盤の新展開
- Principal Investigator
  
  吉開泰信
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Nagoya University
H.pylori菌感染症の病型決定因子に関する集学的研究
- Principal Investigator
  
  若月芳雄
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  Kyoto University
Characterization of Novel Mucosal Modulator for IgAPrincipal Investigator
- Principal Investigator
  
  KIYONO Hiroshi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Immunology
- Research Institution
  Osaka University
Basic Research for AIDS control A02 ; Pathophysiology and immunology of HIV-1 infection
- Principal Investigator
  
  UCHIYAMA Takashi
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  KYOTO UNIVERSITY
The mucosal immune system of the upper respiratory tract and development of nasal vaccine for upper respiratory tract infection
- Principal Investigator
  
  MOGI Goro
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Oita Medical University
Establishment of disease mechanism of inflammatory and allergic disorders in the intestinal mucosa from the mucosal immune system and development for their treatments
- Principal Investigator
  
  NAGURA Hiroshi
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Human pathology
- Research Institution
  Tohoku University
A study of the environmental factors for the development of inflammatory bowel disease
- Principal Investigator
  
  INOUE Yoshifumi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Osaka University
感染症と免疫病の分子生物学と医学
- Principal Investigator
  
  山西弘一, 岸本忠三
- Project Period (FY)
  1997 – 2003
- Research Category
  
  Grant-in-Aid for COE Research
- Research Institution
  Osaka University
Application of a whitelight laser and dye to medical treatment.
- Principal Investigator
  
  KAMEMARU Shun-ichi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Applied optics/Quantum optical engineering
- Research Institution
  Kitami Institute of Technology
Characterization of mucosal intranet formed by γδ/αβ T cells and epithelial cellsPrincipal Investigator
- Principal Investigator
  
  KIYONO Hiroshi
- Project Period (FY)
  1997 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (A).
- Research Field
  
  Immunology
- Research Institution
  Osaka University
AIDS粘膜ワクチン:Th1/Th2型細胞によるHIV特異的粘膜免疫の誘導Principal Investigator
- Principal Investigator
  
  清野宏
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
Regulation of Gene Expression
- Principal Investigator
  
  TANIGUCHI Masaru
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Chiba University, School of Medicine
Mucosal Vaccines : Vectors and Adjuvants for Novel Th1 and Th2 cellsPrincipal Investigator
- Principal Investigator
  
  KIYONO Hiroshi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Immunology
- Research Institution
  Osaka University
エイズの病態と制御に関する基礎研究柱3.病態の免疫学的基盤
- Principal Investigator
  
  UCHIYAMA Takashi
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
AIDS粘膜ワクチン:Th1/Th2型細胞によるHIV特異的粘膜免疫の誘導Principal Investigator
- Principal Investigator
  
  清野宏
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
Visualized measurement of cell by laser and fluorescence dye, -Its application to immunology and cancer treatment-
- Principal Investigator
  
  FUJII Kanichi
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Ibaraki University

[Book] 次世代アジュバント開発のためのメカニズム解明と安全性評価2017
- Author(s)
  清野宏、幸　義和、中橋　理佳、畔上　達彦
- Total Pages
  354
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-23229004
[Book] リンパ学会誌2016
- Author(s)
  Nakahashi, R., Nagatake, T. and Kiyono, H.
- Publisher
  株式会社ライフメディコム
- Data Source
  KAKENHI-PROJECT-23229004
[Book] 実験医学2016
- Author(s)
  Nakahashi, R. and Kiyono, H.
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-23229004
[Book] 歯界展望2017年特別号2016
- Author(s)
  Kishikawa, S. and Kiyono, H.
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-23229004
[Book] Medical Science Digest2016
- Author(s)
  Azegami, T. and Kiyono, H.
- Publisher
  New Science
- Data Source
  KAKENHI-PROJECT-23229004
[Book] 粘膜免疫の最新情報2016
- Author(s)
  Yoshihara, S. and Kiyono, H.
- Total Pages
  5
- Publisher
  日本口腔・咽頭科学会　事務局
- Data Source
  KAKENHI-PROJECT-23229004
[Book] 化学療法の領域2016
- Author(s)
  Kashima, K., Takeyama, N., Yuki, Y. and Kiyono, H.
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-23229004
[Book] 細胞工学(粘膜免疫システム)2011
- Author(s)
  清野宏
- Publisher
  (株)秀潤社
- Data Source
  KAKENHI-PROJECT-20249028
[Book] 臨床粘膜免疫学2010
- Author(s)
  清野宏
- Total Pages
  722
- Publisher
  株式会社シナジー
- Data Source
  KAKENHI-PLANNED-19059003
[Book] 臨床粘膜免疫学2010
- Author(s)
  清野宏
- Total Pages
  722
- Publisher
  (株)シナジー
- Data Source
  KAKENHI-PROJECT-20249028
[Book] 臨床粘膜免疫学2010
- Author(s)
  清野宏
- Total Pages
  722
- Publisher
  株式会社シナジー
- Data Source
  KAKENHI-PROJECT-20249028
[Book] 臨床粘膜免疫学
- Author(s)
  清野宏
- Publisher
  (株)シナジー
- Data Source
  KAKENHI-PLANNED-19059003
[Journal Article] MicroRNA-mediated dynamic control of mucosal immunity.2017
- Author(s)
  Park, EJ., Shimaoka, M. and Kiyono, H.
- Journal Title
  
  Int Immunol
  
  Volume: - Pages: 157-163
- DOI
  10.1093/intimm/dxx019
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23229004, KAKENHI-PROJECT-16K08581, KAKENHI-PROJECT-16K15759
[Journal Article] E-NPP3 controls plasmacytoid dendritic cell numbers in the small intestine.2017
- Author(s)
  Furuta, Y., Tsai, S-H., Kinoshita, M., Fujimoto, K., Okumura, R., Umemoto, E., Kurashima, Y, Kiyono, H., Kayama, H., Takeda, K.
- Journal Title
  
  PLoS One
  
  Volume: 12
- DOI
  10.1371/journal.pone.0172509
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23229004, KAKENHI-PROJECT-15H02511, KAKENHI-PROJECT-15K15152, KAKENHI-PROJECT-16K08838
[Journal Article] Mucosal Ecological Network of Epithelium and Immune Cells for Gut Homeostasis and Tissue Healing2017
- Author(s)
  Kurashima, Y. and Kiyono, H.
- Journal Title
  
  Annu Rev Immunol.
  
  Volume: - Pages: 119-147
- DOI
  10.1146/annurev-immunol-051116-052424
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23229004, KAKENHI-PROJECT-16H06243
[Journal Article] Critical role of interleukin-4 modulating regulatory T cells for desensitization, tolerance and inflammation of food allergy.2017
- Author(s)
  Nakajima-Adachi, H., Shibahara, K., Fujimura, Y., Takeyama, J., Hiraide, E., Kikuchi, A., Murakami, H., Hosono, A., Nochi, T., Wakatsuki, Y., Shimojo, N., Kaminogawa, S., Sato, R., Kiyono, H. and Hachimura, S.
- Journal Title
  
  PLoS ONE
  
  Volume: 12
- DOI
  10.1371/journal.pone.0172795
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23229004, KAKENHI-PROJECT-16H06207, KAKENHI-PROJECT-26292065, KAKENHI-PROJECT-26660245, KAKENHI-PROJECT-15K07443
[Journal Article] Epithelial extracellular ATP: an initiator of immunity to parasitic infections2017
- Author(s)
  Nelson, S., Kiyono, H. and Kurashima, Y.
- Journal Title
  
  Immunology and Cell Biology
  
  Volume: 95 Pages: 117-8
- DOI
  10.1038/icb.2016.106
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23229004, KAKENHI-PROJECT-16H06243
[Journal Article] Nanogel-based nasal ghrelin vaccine prevents obesity.2017
- Author(s)
  Azegami, T., Yuki, Y., Sawada, S,, Mejima, M., Ishige, K., Akiyoshi, K., Itoh, H. and Kiyono H.
- Journal Title
  
  Mucosal Immunology
  
  Volume: -
- DOI
  10.1038/mi.2016.137
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23229004
[Journal Article] Seed Metabolome analysis of a transgenic rice line expressing cholera toxin B-subunit.2017
- Author(s)
  Ogawa, T., Kashima, K., Yuki, Y., Mejima, M., Kurokawa, S., Okazawa, A., Kiyono, H. and Ohta, D.
- Journal Title
  
  Science Reports
  
  Volume: -
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23229004
[Journal Article] Critical role of TSLP-responsive mucosal dendritic cells in the induction of nasal antigen-specific IgA response2017
- Author(s)
  Joo,S., Fukuyama, Y., Park,E-J., Yuki, Y., Kurashima, Y., Ziegler, S.F. and Kiyono,H.
- Journal Title
  
  Mucosal Immunol.
  
  Volume: - Pages: 901-911
- DOI
  10.1038/mi.2016.103
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23229004, KAKENHI-PROJECT-16K08581, KAKENHI-PROJECT-16H06243
[Journal Article] Allograft inflammatory factor 1 is a regulator of transcytosis in M cells2017
- Author(s)
  Kishikawa, S., Sato, S., Kaneto, S. Uchino, S., Kohsaka, S., Nakamura, S. and Kiyono, H.
- Journal Title
  
  Nat Commun
  
  Volume: 8 Pages: 14509-14509
- DOI
  10.1038/ncomms14509
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23229004, KAKENHI-PROJECT-16K08836, KAKENHI-PLANNED-25117009
[Journal Article] The spleen is the site where mast cells are induced in the development of food allergy.2017
- Author(s)
  Toyoshima, S., Wakamatsu, E., Ishida, Y., Obata, Y., Kurashima, Y., Kiyono, H. and Abe, R.
- Journal Title
  
  International Immunology
  
  Volume: -
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23229004
[Journal Article] Impaired airway mucociliary function reduces antigen-specific IgA immune response to immunization with a claudin-4-targeting nasal vaccine in mice.2017
- Author(s)
  Kunisawa, J., Yagi, K., Ikegami, K., Hamazaki, Y., Suzuki, H., Nagatake, T., Kiyono, H., Kondoh, M., Nasu, A. and Setou, M.
- Journal Title
  
  Journal of Controlled Release
  
  Volume: -
- NAID
  120006551757
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23229004
[Journal Article] ISH NIA OS-02 attenuation of hypertension by less-invasive intranasal vaccination against angiotensin II type 1 receptor in spontaneously hypertensive rats.2016
- Author(s)
  Azegami, T., Yuki, Y., Hayashi, K., Nakamura, M., Hishikawa, A., Kiyono, H. and Itoh, H.
- Journal Title
  
  Journal of Hypertension
  
  Volume: 1 Pages: 42-42
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23229004
[Journal Article] Epithelial glycosylation in gut homeostasis and inflammation2016
- Author(s)
  Goto, Y., Uematsu, S. and Kiyono, H.
- Journal Title
  
  Nat Immunol.
  
  Volume: 17 Pages: 1244-1251
- DOI
  10.1038/ni.3587
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23229004, KAKENHI-PUBLICLY-15H01367, KAKENHI-PROJECT-16H06229, KAKENHI-PROJECT-15K14404
[Journal Article] Differential analyses of major allergen proteins in wild-type rice and rice producing a fragment of anti-rotavirus antibody.2016
- Author(s)
  Yuki Y, Kurokawa S, Kozuka-Hata H, Tokuhara D, Mejima M, Kuroda M, Oyama M, Nishimaki-Mogami T, Teshima R, Kiyono H.
- Journal Title
  
  Regul Toxicol Pharmacol.
  
  Volume: 76 Pages: 128-136
- DOI
  10.1016/j.yrtph.2016.01.023
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26505001, KAKENHI-PROJECT-23229004, KAKENHI-PLANNED-16H06578
[Journal Article] MicroRNA-orchestrated pathophysiologic control in gut homeostasis and inflammation.2016
- Author(s)
  Lee, J., Park, E.J. and Kiyono H.
- Journal Title
  
  BMB Reports
  
  Volume: 49 Pages: 263-9
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23229004
[Journal Article] The Ectoenzyme E-NPP3 Negatively Regulates ATP-Dependent Chronic Allergic Responses by Basophils and Mast Cells.2015
- Author(s)
  Tsai, S-H., Kinoshita, M., Kusu, T., Kayama, H., Okumura, R., Ikeda, K., Shimada, Y., Takeda, A., Yoshikawa, S., Obata-Ninomiya, K., Kurashima, Y., Sato, S., Umemoto, E., Kiyono, H., Karasuyama, H. and Takeda, K.
- Journal Title
  
  Immunity
  
  Volume: 42(2) Pages: 279-293
- DOI
  10.1016/j.immuni.2015.01.015
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23229004, KAKENHI-PLANNED-24111005, KAKENHI-PROJECT-24390093, KAKENHI-PROJECT-24390120, KAKENHI-PROJECT-24590252, KAKENHI-PROJECT-25860353, KAKENHI-PROJECT-26870172, KAKENHI-PROJECT-26893047
[Journal Article] A Novel Transgenic Rice-based Vaccine:2015
- Author(s)
  Azegami, T., Itoh, H., Kiyono, H. and Yuki, Y.
- Journal Title
  
  Arch. Immunol. Ther. Ex
  
  Volume: 63(2) Pages: 87-99
- DOI
  10.1007/s00005-014-0303-0
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23229004, KAKENHI-PROJECT-24659203
[Journal Article] レチノイン酸代謝による皮膚バリアの恒常性維持－線維芽細胞によるマスト細胞調節機構－2015
- Author(s)
  佐藤健、倉島洋介、國澤純、清野宏
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 63(2) Pages: 139-145
- Data Source
  KAKENHI-PROJECT-23229004
[Journal Article] Negative regulation of DSS-induced experimental colitis by PILRα2015
- Author(s)
  Kishida, K., Kohyama, M., Kurashima, Y., Kogure, Y., Wang, J., Hirayasu, K., Suenaga, T., Kiyono, H., Kunisawa, J. and Arase, H.
- Journal Title
  
  International immunology
  
  Volume: - Pages: 307-314
- DOI
  10.1093/intimm/dxv004
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23229004, KAKENHI-PROJECT-23390112, KAKENHI-PLANNED-24115005, KAKENHI-PROJECT-24590584, KAKENHI-PUBLICLY-25133705, KAKENHI-PROJECT-25460565, KAKENHI-PROJECT-25670143, KAKENHI-PROJECT-26870334, KAKENHI-PROJECT-26893047
[Journal Article] Nanogel-based pneumococcal surface protein A nasal vaccine induces microRNA-associated Th17 cell responses with neutralizing antibodies against Streptococcus pneumonia in macaques.2015
- Author(s)
  Fukuyama, Y., Yuki, Y., Katakai, Y., Harada, N., Takahashi, H., Takeda, S., Mejima, M., Joo, S., Kurokawa, S., Sawada, S., Shibata, H., Park, EJ., Fujihashi., K, Briles, D., Yasutomi, Y., Tsukada, H., Akiyoshi, K., Kiyono, H.
- Journal Title
  
  Mucosal Immunology
  
  Volume: -
- DOI
  10.1038/mi.2015.5
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23229004, KAKENHI-PROJECT-24659203, KAKENHI-PROJECT-25670225
[Journal Article] Loss of Lymph Node Fibroblastic Reticular Cells and High Endothelial Cells Is Associated with Humoral Immunodeficiency in Mouse Graft-versus-Host Disease.2015
- Author(s)
  Suenaga, F., Ueha, S., Abe, J., Kosugi-Kanaya, M., Wang, Y., Yokoyama, A., Shono, Y., Shand, F. H., Morishita, Y., Kunisawa, J., Sato, S., Kiyono, H. and Matsushima, K.
- Journal Title
  
  J Immunol.
  
  Volume: 194(1) Pages: 398-406
- DOI
  10.4049/jimmunol.1401022
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23229004, KAKENHI-PROJECT-25293113, KAKENHI-PROJECT-25460491, KAKENHI-PROJECT-25860353
[Journal Article] 腸管バリアとしての糖鎖修飾とその制御2015
- Author(s)
  後藤義幸、清野宏
- Journal Title
  
  実験医学
  
  Volume: 33(4) Pages: 544-549
- Data Source
  KAKENHI-PROJECT-23229004
[Journal Article] Comparative whole-genome analyses of selection marker–free rice-based cholera toxin B-subunit vaccine lines with wild-type lines.2015
- Author(s)
  Kashima, K., Mejima, M., Kurokawa, S., Kuroda, M., Kiyono, H. and Yuki, Y.
- Journal Title
  
  BMCGgenomics
  
  Volume: 48 Pages: 48-48
- DOI
  10.1186/s12864-015-1285-y
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23229004, KAKENHI-PROJECT-24659203
[Journal Article] Development of selection marker-free rice-based oral cholera toxin B-subunit vaccine and characterization of location and structure of transgene by using whole genome resequencing analysis.2015
- Author(s)
  Mejima, M., Kashima, K., Kuroda, M., Takeyama, N., Kurokawa S., Fukuyama Y., Kiyono H., Itoh, K., Mitsui, T., and Yuki, Y.
- Journal Title
  
  Plant Cell Tiss. Org. Cult.
  
  Volume: 120 Pages: 35-48
- DOI
  10.1007/s11240-014-0575-4
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23229004, KAKENHI-PROJECT-24659203
[Journal Article] Mucosal immunosenescence in the gastrointestinal tract: A mini-review.2015
- Author(s)
  Sato, S., Kiyono, H. and Fujihashi, K.
- Journal Title
  
  Gerontology
  
  Volume: -
- DOI
  10.1159/000368897
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23229004
[Journal Article] Vitamins mediate immunological homeostasis and diseases at the surface of the body.2015
- Author(s)
  Kunisawa J. and Kiyono H.
- Journal Title
  
  Endocr. Metab. Immune Disord. Drug Targets
  
  Volume: 15(1) Pages: 25-30
- DOI
  10.2174/1871530314666141021114651
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23229004
[Journal Article] Skin-barrier homeostasis through Cyp26b1-mediated inhibition of ATP-dependent mast-cell activation by fibroblasts2014
- Author(s)
  Kurashima Y, Amiya T, Fjisawa K, Shibata N, Suzuki Y, Kogure Y, Hashimoto E, Otsuka A, Kabashima K, Sato S, Sato T, Kubo M, Akira S, Miyake K, Kunisawa J, Kiyono H.
- Journal Title
  
  Immunity
  
  Volume: 40 Pages: 530-41
- DOI
  10.1016/j.immuni.2014.01.014
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-11J04859, KAKENHI-PROJECT-23229004, KAKENHI-PROJECT-24249058, KAKENHI-PROJECT-24659217, KAKENHI-PUBLICLY-25116706, KAKENHI-PROJECT-25860353, KAKENHI-PROJECT-26293111, KAKENHI-PROJECT-26670241, KAKENHI-PROJECT-26893047
[Journal Article] Specific Expression of Apolipoprotein A-IV in the Follicle-Associated Epithelium of the Small Intestine2014
- Author(s)
  Tokuhara, D., Nochi, T., Matsumura, A., Mejima, M., Takahashi, Y., Kurokawa, S., Kiyono, H. and Yuki Y.
- Journal Title
  
  Dig Dis Sci.
  
  Volume: 59 Pages: 2682-2692
- DOI
  10.1007/s10620-014-3203-6
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23229004, KAKENHI-PROJECT-24659203, KAKENHI-PROJECT-26660245
[Journal Article] A rice-based soluble form of a murine TNF -specific llama variable domain of heavy-chain antibody suppresses collagen -induced arthritis in mice.2014
- Author(s)
  Abe, M., Yuki, Y., Kurokawa, S., Mejima, M., Kuroda, M., Park, E.J., Scheller, J. Nakanishi, U. and Kiyono, H.
- Journal Title
  
  J. Biotechnol.
  
  Volume: 10:175 Pages: 45-52
- DOI
  10.1016/j.jbiotec.2014.02.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23229004
[Journal Article] Innate lymphoid cells regulate intestinal epithelial cell glycosylation.2014
- Author(s)
  Goto, Y., Obata, T., Kunisawa, J., Sato, S., Ivanov, I., Lamichhane, A., Takeyama, N., Kamioka, M., Sakamoto, M., Matsuki, T., Setoyama, H., Imaoka, A., Uematsu, S., Akira, S., Domino, S., Kulig, P., Becher, B., Renauld, J-C., Sasakawa, C., Umesaki, Y., Benno, Y. and Kiyono, H.
- Journal Title
  
  Science
  
  Volume: 345(6202) Pages: 1254009-1254009
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23229004
[Journal Article] The mucosal immune system for vaccine development.2014
- Author(s)
  Lamichhane, A., Azegami, T. and Kiyono, H.
- Journal Title
  
  Vaccine
  
  Volume: 32(49) Pages: 6711-6723
- DOI
  10.1016/j.vaccine.2014.08.089
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23229004
[Journal Article] Runx2-I Isoform Contributes to Fetal Bone Formation Even in the Absence of Specific N-Terminal Amino Acids.2014
- Author(s)
  Nakajima-Adachi, H., Kikuchi, A., Fujimura, Y., Shibahara, K., Makino, T., Goseki-Sone, M., Kihara-Fujioka, M., Nochi, T., Kurashima, Y., Igarashi, O., Yamamoto, M., Kunisawa, J., Toda, M., Kaminogawa, S., Sato, R., Kiyono, H., and Hachimura, S.
- Journal Title
  
  PLoS One
  
  Volume: 9 Pages: 108294-108294
- DOI
  10.1371/journal.pone.0108294
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23229004, KAKENHI-PROJECT-24390412, KAKENHI-PROJECT-25670773, KAKENHI-PROJECT-25860353
[Journal Article] Generation of colonic IgA-secreting cells in the caecal patch.2014
- Author(s)
  Masahata, K., Umemoto, E., Kayama, H., Kotani, M., Nakamura, S., Kurakawa, T., Kikuta, J., Gotoh, K., Motooka, D., Sato, S., Higuchi, T., Baba, Y., Kurosaki, T., Kinoshita, M., Shimada, Y., Kimura, T., Okumura, R., Takeda, A., Tajima, M., Yoshie, O., Fukuzawa, M., Kiyono, H., Fagarasan, S., Iida, T., Ishii, M., Takeda, K
- Journal Title
  
  Nature Comm.
  
  Volume: 5 Pages: 1-13
- DOI
  10.1038/ncomms4704
- NAID
  40020212243
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-21229007, KAKENHI-PROJECT-23229004, KAKENHI-PROJECT-23501273, KAKENHI-PROJECT-23591632, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111005, KAKENHI-PROJECT-24390120, KAKENHI-PROJECT-24590252, KAKENHI-PROJECT-24689023, KAKENHI-PROJECT-25670272, KAKENHI-PROJECT-25860353, KAKENHI-PROJECT-25893117, KAKENHI-PROJECT-26221306, KAKENHI-PROJECT-26460582, KAKENHI-PROJECT-26461437
[Journal Article] 次世代ワクチン開発への課題と挑戦-経口ワクチン-2014
- Author(s)
  鹿島光司、幸義和、清野宏
- Journal Title
  
  BIO INDUSTRY
  
  Volume: 31(6) Pages: 4-10
- Data Source
  KAKENHI-PROJECT-23229004
[Journal Article] Vaginal memory T cells induced by intranasal vaccination are critical for protective T cell recruitment and prevention of genital HSV-2 disease.2014
- Author(s)
  Sato, A., Suwanto, A., Okabe, M., Sato, S., Nochi, T., Imai, T., Koyanagi, N., Kunisawa, J., Kawaguchi, Y. and Kiyono, H.
- Journal Title
  
  J. Virol.
  
  Volume: 88(23) Pages: 13699-13708
- DOI
  10.1128/jvi.02279-14
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23229004, KAKENHI-PROJECT-25860353, KAKENHI-PROJECT-26660245
[Journal Article] New era for mucosal mast cells: their roles in inflammation, allergic immune responses and adjuvant development.2014
- Author(s)
  Kurashima Y, Kiyono H.
- Journal Title
  
  Exp. Mol. Med.
  
  Volume: 46
- DOI
  10.1038/emm.2014.7
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-11J04859, KAKENHI-PROJECT-23229004, KAKENHI-PROJECT-26893047
[Journal Article] 粘膜ワクチンを基盤とした次世代ワクチンの開発2014
- Author(s)
  福山賀子、清野宏
- Journal Title
  
  最新医学
  
  Volume: 69(4) Pages: 62-69
- Data Source
  KAKENHI-PROJECT-23229004
[Journal Article] 抑制型免疫システムを応用した次世代型抗アレルギーワクチンの開発2014
- Author(s)
  高里良宏、倉島洋介、清野宏、國澤純
- Journal Title
  
  BIO INDUSTRY
  
  Volume: 31(6) Pages: 55-60
- Data Source
  KAKENHI-PROJECT-23229004
[Journal Article] Regulation of intestinal IgA responses by dietary palmitic acid and its metabolism2014
- Author(s)
  Kunisawa J, Hashimoto E, Inoue A, Nagasawa R, Suzuki Y, Ishikawa I, Shikata S, Arita M, Aoki J, Kiyono H.
- Journal Title
  
  J Immunol
  
  Volume: 193 Pages: 1666-1671
- DOI
  10.4049/jimmunol.1302944
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-22116001, KAKENHI-PLANNED-22116006, KAKENHI-PROJECT-23229004, KAKENHI-PROJECT-24659217, KAKENHI-PUBLICLY-25116706, KAKENHI-PROJECT-26293111, KAKENHI-PROJECT-26670241
[Journal Article] Challenge in mucosal vaccines for the control of infectious diseases.2014
- Author(s)
  Azegami, T., Yuki, Y., and Kiyono, H.
- Journal Title
  
  Int. Immunol.
  
  Volume: 26 Pages: 517-528
- DOI
  10.1093/intimm/dxu063
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23229004
[Journal Article] 細胞外核酸を介したマスト細胞の活性化と炎症性腸疾患2014
- Author(s)
  倉島洋介、清野宏、國澤純
- Journal Title
  
  生化学
  
  Volume: 86(6) Pages: 798-802
- NAID
  40020314288
- Data Source
  KAKENHI-PROJECT-23229004
[Journal Article] 自然リンパ球による腸管上皮細胞の糖鎖修飾誘導・制御システム2014
- Author(s)
  後藤義幸、清野宏
- Journal Title
  
  分子消化器病
  
  Volume: 11(4) Pages: 86-88
- Data Source
  KAKENHI-PROJECT-23229004
[Journal Article] Peyer's patches play a protective role in nonsteroidal anti-inflammatory drug-induced enteropathy in mice2014
- Author(s)
  Hiyama S, Iijima H, Shinzaki S, Inoue T, Shiraishi E, Kawai S, Araki M, Kato M, Hayashi Y, Nishida T, Fujii H, Mukai A, Shibata N, Sato S, Kiyono H, Gotoh K, Motooka D, Nakamura S, Iida T, Tsujii M, Takehara T.
- Journal Title
  
  Inflammatory Bowel Diseases
  
  Volume: 5 Pages: 790-799
- DOI
  10.1097/mib.0000000000000017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-14J08881, KAKENHI-PROJECT-23229004, KAKENHI-PROJECT-23590941, KAKENHI-PROJECT-24390188, KAKENHI-PROJECT-25860353, KAKENHI-PROJECT-26460969
[Journal Article] Mucosal adjuvants for vaccines to control upper respiratory infections in the elderly.2014
- Author(s)
  Fujihashi, K., Sato S., and Kiyono, H.
- Journal Title
  
  Experimental Gerontology
  
  Volume: 54 Pages: 21-26
- DOI
  10.1016/j.exger.2014.01.006
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23229004, KAKENHI-PROJECT-25860353
[Journal Article] Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors2012
- Author(s)
  Kurashima Y, Amiya T, Nochi T, Fujisawa K, Haraguchi T, Iba H, Tsutsui H, Sato S, Nakajima S, Iijima H, Kubo M, Kunisawa J, Kiyono H
- Journal Title
  
  Nat Commun
  
  Volume: 3 Pages: 1034-1034
- Data Source
  KAKENHI-PROJECT-23590941
[Journal Article] Epithelial barrier: an interface for the cross-communication between gut flora and immune system.2012
- Author(s)
  Goto, Y., Kiyono, H.
- Journal Title
  
  Immunol Rev.
  
  Volume: 245 Pages: 147-163
- DOI
  10.1111/j.1600-065x.2011.01078.x
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-19059009, KAKENHI-PROJECT-23229004
[Journal Article] Peaceful mutualism in the gut : revealing key commensal bacteria for the creation and maintenance of immunological homeostasis.2011
- Author(s)
  Kunisawa J, Kiyono H.
- Journal Title
  
  Cell Host Microbe.
  
  Volume: 17 Pages: 83-4
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19059003
[Journal Article] The airway antigen sampling system: Respiratory M cells as an alternative gateway for inhaled antigens2011
- Author(s)
  Kim, D-Y., Sato, A., Fukuyama, S., Sagara, H, Nagatake, T., Kong, IG., Goda, K., Nochi, T., Kunisawa, J., Sato, S., Yokota, Y., Lee, CH., and Kiyono, H
- Journal Title
  
  J. Immunol
  
  Volume: 186 Pages: 4253-4262
- Data Source
  KAKENHI-PLANNED-19059003
[Journal Article] Peaceful mutualism in the gut: revealing key commensal bacteria for the creation and maintenance of immunological homeostasis2011
- Author(s)
  Kunisawa, J., and Kiyono, H
- Journal Title
  
  Cell Host Microbe
  
  Volume: 9 Pages: 83-84
- Data Source
  KAKENHI-PLANNED-19059003
[Journal Article] Epithelial cell microRNAs in gut immunity2011
- Author(s)
  Goto, Y., and Kiyono, H
- Journal Title
  
  Nat Immunol
  
  Volume: 12 Pages: 195-197
- Data Source
  KAKENHI-PLANNED-19059003
[Journal Article] Epithelial cell microRNAs in gut immunity.2011
- Author(s)
  Goto Y, Kiyono H.
- Journal Title
  
  Nat Immunol.
  
  Volume: 12 Pages: 195-7
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19059003
[Journal Article] Distinct fucosylation of M cells and epithelial cells by Fut1 and Fut2, respectively, in response to intestinal environmental stress2011
- Author(s)
  Terahara, K., Nochi, T., Yoshida, M., Takahashi, Y., Goto, Y., Hatai, H., Kurokawa, S., Jang, H-M., Kweon, M-N, Domino, SE., Hiroi, T., Yuki, Y., Tsunetsugu-Yokota, Y., Kobayashi, K., and Kiyono, H
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 404 Pages: 822-828
- Data Source
  KAKENHI-PLANNED-19059003
[Journal Article] Distinct fucosylation of M cells and epithelial cells by Fut1 and Fut2, respectively, in response to intestinal environmental stress.2011
- Author(s)
  Terahara K, Nochi T, Yoshida M, Takahashi Y, Goto Y, Hatai H, Kurokawa S, Jang MH, Kweon MN, Domino SE, Hiroi T, Yuki Y, Tsunetsugu-Yokota Y, Kobayashi K, Kiyono H.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 404 Pages: 822-8
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19059003
[Journal Article] Distinct fucosylation of M cells and epithelial cells by Fut1 and Fut2, respectively, in response to intestinal environmental stress.2011
- Author(s)
  Terahara K, Nochi T, Yoshida M, Takahashi Y, Goto Y, Hatai H, Kurokawa S, Jang MH, Kweon MN, Domino SE, Hiroi T, Yuki Y, Tsunetsugu-Yokota Y, Kobayashi K, Kiyono H.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 404 Pages: 822-828
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249028
[Journal Article] Secretory IgA-mediated protection against V.cholerae and heat-labile enterotoxin-producing enterotoxigenic Escherichia coli by rice-based vaccine.2010
- Author(s)
  Tokuhara D, Yuki Y, Nochi T, Kodama T, Mejima M, Kurokawa S, Takahashi Y, Nanno M, Nakanishi U, Takaiwa F, Honda T, Kiyono H.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 107 Pages: 8794-9
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19059003
[Journal Article] Mucosal regulatory cells in the gastrointestinal tract and periodontium.2010
- Author(s)
  Takahashi I, Fujihashi K, Kiyono H.
- Journal Title
  
  Periodontol
  
  Volume: 54 Pages: 247-256
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249028
[Journal Article] In vivo molecular imaging analysis of a nasal vaccine that induces protective immunity against botulism in nonhuman primates.2010
- Author(s)
  Yuki Y, Nochi T, Harada N, Katakai Y, Shibata H, Mejima M, Kohda T, Tokuhara D, Kurokawa S, Takahashi Y, Ono F, Kozaki S, Terao K, Tsukada H, Kiyono H.
- Journal Title
  
  J Immunol.
  
  Volume: 185 Pages: 5436-43
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19059003
[Journal Article] Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus.2010
- Author(s)
  Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S.
- Journal Title
  
  J Virol.
  
  Volume: 84 Pages: 12703-12
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19059003
[Journal Article] Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus.2010
- Author(s)
  Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S.
- Journal Title
  
  J Vjrol.
  
  Volume: 84 Pages: 12703-12712
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249028
[Journal Article] Aberrant interaction of the gut immune system with environmental factors in the development of food allergies.2010
- Author(s)
  Kunisawa J, Kiyono H.
- Journal Title
  
  Curr Allergy Asthma Rep.
  
  Volume: 10 Pages: 215-21
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19059003
[Journal Article] Indigenous opportunistic bacteria inhabit mammalian gut-associated lymphoid tissues and share a mucosal antibody-mediated symbiosis.2010
- Author(s)
  Obata T, Goto Y, Kunisawa J, Sato S, Sakamoto M, Setoyama H, Matsuki T, Nonaka K, Shibata N, Gohda M, Kagiyama Y, Nochi T, Yuki Y, Fukuyama Y, Mukai A, Shinzaki S, Fujihashi K, Sasakawa C, Iijima H, Goto M, Umesaki Y, Benno Y, Kiyono H.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 107 Pages: 7419-24
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19059003
[Journal Article] Aberrant interaction of the gut immune system with environmental factors in the development of food allergies.2010
- Author(s)
  Kunisawa J, Kiyono H.
- Journal Title
  
  Curr Allergy Asthma Rep. 10
  
  Pages: 215-221
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249028
[Journal Article] Antigen-sampling cells in the salmonid intestinal epithelium.2010
- Author(s)
  Fuglem B, Jirillo E, Bjerkas I, Kiyono H, Nochi T, Yuki Y, Raida M, Fischer U, Koppang EO.
- Journal Title
  
  Dev Comp Immunol.
  
  Volume: 34 Pages: 768-774
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249028
[Journal Article] IL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease-associated inflammation and lymphomagenesis.2010
- Author(s)
  Malamut G, El Machhour R, Montcuquet N, Martin-Lanneree S, Dusanter-Fourt I, Verkarre V, Mention JJ, Rahmi G, Kiyono H, Butz EA, Brousse N, Cellier C, Cerf-Bensussan N, Meresse B.
- Journal Title
  
  J Clin Invest.
  
  Volume: 120 Pages: 2131-43
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19059003
[Journal Article] Nanogel antigenic protein-delivery system for adjuvant-free intranasal vaccines.2010
- Author(s)
  Nochi T, Yuki Y, Takahashi H, Sawada S, Mejima M, Kohda T, Harada N, Kong IG, Sato A, Kataoka N, Tokuhara D, Kurokawa S, Takahashi Y, Tsukada H, Kozaki S, Akiyoshi K, Kiyono H.
- Journal Title
  
  Nat Mater.
  
  Volume: 9 Pages: 572-8
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19059003
[Journal Article] Secretory IgA-mediated protection against V. cholerae and heat-labile enterotoxin-producing enterotoxigenic Escherichia coli by rice-based vaccine2010
- Author(s)
  Tokuhara, D., Yuki, Y., Nochi, T., Kodama, T., Mejima, M., Kurokawa, S., Takahashi, Y., Nanno, M., Nakanishi, U., Takaiwa, F., Honda, T., and Kiyono, H
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: 107 Pages: 8794-8799
- Data Source
  KAKENHI-PLANNED-19059003
[Journal Article] Mucosal regulatory cells in the gastrointestinal tract and periodontium.2010
- Author(s)
  Takahashi I, Fujihashi K, Kiyono H.
- Journal Title
  
  Periodontol
  
  Volume: 54 Pages: 247-56
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19059003
[Journal Article] Nanogel antigenic protein-delivery system for adjuvant-free intranasal vaccines2010
- Author(s)
  Nochi, T., Yuki, Y., Takahashi, H., Sawada, SI., Mejima, M., Kohda, T., Harada, N., Kong, IG., Sato, A., Kataoka, N., Tokuhara, D., Kurokawa, S., Takahashi, Y., Tsukada, H., Kozaki, S., Akiyoshi, K., and Kiyono, H
- Journal Title
  
  Nature Mater
  
  Volume: 9 Pages: 572-578
- Data Source
  KAKENHI-PLANNED-19059003
[Journal Article] High affinity of interaction between superantigen and T cell receptor Vbeta molecules induces a high level and prolonged expansion of superantigen-reactive CD4+ T cells.2010
- Author(s)
  Omoe K, Nunomura W, Kato H, Li ZJ, Igarashi O, Araake M, Sano K, Ono HK, Abe Y, Hu DL, Nakane A, Kiyono H, Takakuwa Y, Shinagawa K, Uchiyama T, Imanishi K.
- Journal Title
  
  J Biol Chem.
  
  Volume: 285 Pages: 30427-35
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19059003
[Journal Article] In vivo molecular imaging analysis of a nasal vaccine that induces protective immunity against botulism in nonhuman primates.2010
- Author(s)
  Yuki Y, Nochi T, Harada N, Katakai Y, Shibata H, Mejima M, Kohda T, Tokuhara D, Kurokawa S, Takahashi Y, Ono F, Kozaki S, Terao K, Tsukada H, Kiyono H.
- Journal Title
  
  JImmunol.
  
  Volume: 185 Pages: 5436-5443
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249028
[Journal Article] IL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease-associated inflammation and lymphomagenesis.2010
- Author(s)
  Malamut G, El Machhour R, Montcuquet N, Martin-Lanneree S, Dusanter-Fourt I, Verkarre V, Mention JJ, Rahmi G, Kiyono H, Butz EA, Brousse N, Cellier C, Cerf-Bensussan N, Meresse B.
- Journal Title
  
  J Clin Invest.
  
  Volume: 120 Pages: 2131-2143
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249028
[Journal Article] Indigenous opportunistic bacteria inhabit mammalian gut-associated lymphoid tissues and share a mucosal antibody-mediated symbiosis2010
- Author(s)
  Obata, T., Goto, Y., Kunisawa, J., Sato, S., Sakamoto, M., Setoyama, H., Matsuki, T., Nonaka, K., Shibata, N., Gohda, M., Kagiyama, Y., Nochi, T., Yuki, Y., Fukuyama, Y., Mukai, A., Shinzaki, S., Fujihashi, K., Sasakawa, C., Iijima, H., Goto, M., Umesaki, Y., Benno, Y., and Kiyono, H
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: 107 Pages: 7419-7424
- Data Source
  KAKENHI-PLANNED-19059003
[Journal Article] Aberrant interaction of the gut immune system with environmentalfactors in the development of food allergies.2010
- Author(s)
  Kunisawa J, Kiyono H.
- Journal Title
  
  Curr Allergy Asthma Rep.
  
  Volume: 10 Pages: 215-221
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249028
[Journal Article] Nanogel antigenic protein-delivery system for adjuvant-free intranasal vaccines.2010
- Author(s)
  Nochi T, Yuki Y, Takahashi H, Sawada S, Mejima M, Kohda T, Harada N, Kong IG, Sato A, Kataoka N, Tokuhara D, Kurokawa S, Takahashi Y, Tsukada H, Kozaki S, Akiyoshi K, Kiyono H.
- Journal Title
  
  Nat Mater.
  
  Volume: 9 Pages: 572-578
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249028
[Journal Article] Secretory IgA-mediated protection against V.cholerae and heat-labileenterotoxin-producing enterotoxigenic Escherichia coli by rice-based vaccine.2010
- Author(s)
  Tokuhara D, Yuki Y, Nochi T, Kodama T, Mejima M, Kurokawa S, Takahashi Y, Nanno M, Nakanishi U, Takaiwa F, Honda T, Kiyono H.
- Journal Title
  
  Proc Natl Acad Sci USA.
  
  Volume: 107 Pages: 8794-8799
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249028
[Journal Article] Indigenous opportunistic bacteria inhabit mammalian gut-associatedlymphoid tissues and share a mucosal antibody-mediated symbiosis.2010
- Author(s)
  Obata T, Goto Y, Kunisawa J, Sato S, Sakamoto M, Setoyama H, Matsuki T, Nonaka K, Shibata N, Gohda M, Kagiyama Y, Nochi T, Yuki Y, Fukuyama Y, Mukai A, Shinzaki S, Fujihashi K, Sasakawa C, Iijima H, Goto M, Umesaki Y, Benno Y, Kiyono H.
- Journal Title
  
  Proc Natl Acad Sci USA.
  
  Volume: 107 Pages: 7419-7424
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249028
[Journal Article] Mucosal vaccines : novel advances in technology and delivery2009
- Author(s)
  Yuki, Y., Kiyono, H.
- Journal Title
  
  Expert Rev Vaccines 8
  
  Pages: 1083-1097
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19059003
[Journal Article] Mucosal vaccines : novel advances in technology and delivery.2009
- Author(s)
  Yuki, Y., Kiyono, H.
- Journal Title
  
  Expert Rev Vaccines. 8
  
  Pages: 1083-1097
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249028
[Journal Article] A Rice-based oral cholera vaccine induces macaque-specific systemic neutralizing Abs but does not influence pre-existing intestinal immunity2009
- Author(s)
  Nochi, T., Yuki,Y., Katakai, Y., Shibata, H., Tokuhara,D., Mejima, M., Kurokawa,S., Takahashi,Y., Nakanishi, U., Ono, F., Mimuro, H., Sasakawa, S., Takaiwa, F., Terao, K., and Kiyono, H
- Journal Title
  
  J. Immunol
  
  Volume: 183 Pages: 6538-6544
- Data Source
  KAKENHI-PLANNED-19059003
[Journal Article] Id2-, RORγt-, and LTβR-independent lymphoid organogenesis in ocular immunity2009
- Author(s)
  Nagatake, T., Fukuyama, S, Kim. D-Y., Goda, K., Igarashi.O., Sato,S., Nochi, T., Sagara, H.,Yokota, Y., Jetten, AM., Kaisho, T., Akira, A., Mimuro, H., Sasakawa, C., Fukui, Y., Fujihashi, K., Akiyama, T., Inoue, J., Penninger, J.M., Kunisawa, J., and Kiyono, H
- Journal Title
  
  J. Exp. Med
  
  Volume: 206 Pages: 2351-2364
- Data Source
  KAKENHI-PLANNED-19059003
[Journal Article] Mucosal immunosenescence : New developments and vaccines to contr-ol infectious diseases.2009
- Author(s)
  Fujihashi, K., Kiyono, H.
- Journal Title
  
  Trends Immunol. 30
  
  Pages: 334-343
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249028
[Journal Article] Mucosal immunosenescence : New developments and vaccines to control infectious diseases2009
- Author(s)
  Fujihashi, K. and Kiyono, H
- Journal Title
  
  Trends Immunol
  
  Volume: 30 Pages: 334-343
- Data Source
  KAKENHI-PLANNED-19059003
[Journal Article] Mucosal immunosenescence : New developments and vaccines to contr-olinfectious diseases2009
- Author(s)
  Fujihashi, K., Kiyono, H.
- Journal Title
  
  Trends Immunol 30
  
  Pages: 334-343
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19059003
[Journal Article] Uptake through glycoprotein 2 of FimH(+) bacteria by M cells initiates mucosal immune response2009
- Author(s)
  Hase, K., Kawano, K., Nochi, T., Pontes, GS., Fukuda, S., Ebisawa, M., Kadokura, K., Tobe, T., Fujimura, Y., Kawano, S., Yabashi, A., Waguri, S., Nakato, G., Kimura, S., Murakami, T., Iimura, M., Hamura, K., Fukuoka, S., Lowe, AW., Itoh, K., Kiyono, H., and Ohno, H
- Journal Title
  
  Nature
  
  Volume: 462 Pages: 226-230
- Data Source
  KAKENHI-PLANNED-19059003
[Journal Article] RANKL is necessary and sufficient to initiate development of antigen-sampling M cells in the intestinal epithelium2009
- Author(s)
  Knoop, KA., Kumar, N., Butler, BR., Sakthivel, SK., Taylor, RT., Nochi, T., Akiba, H., Yagita, H., Kiyono, H., and Williams, IR
- Journal Title
  
  J. Immunol
  
  Volume: 183 Pages: 5738-5747
- Data Source
  KAKENHI-PLANNED-19059003
[Journal Article] Expression of newly identified secretory CEACAM1(a) isoforms in the intestional epithelium2009
- Author(s)
  Terahara, K., Yoshida, M., Taguchi, F., Igarashi, O., Nochi, T., Gotoh, Y., Yamamoto, T., Tsunetsugu-Yokota, Y., Beauchemin, N., and Kiyono, H
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 383 Pages: 340-346
- Data Source
  KAKENHI-PLANNED-19059003
[Journal Article] Colonic patches direct the cross-talk between systemic compartments and large intestine independently of innate immunity2008
- Author(s)
  Chang, SY., Cha, HR., Uematsu, S., Akira, S., Igarashi, O., Kiyono, H., and Kweon, M-N
- Journal Title
  
  J. Immunol
  
  Volume: 180 Pages: 1609-18
- Data Source
  KAKENHI-PLANNED-19059003
[Journal Article] Peyer's patches are required for intestinal IgA responses to Salmonella.2008
- Author(s)
  Hashizume, T., Togawa, A., Nochi, T., Igarashi, O., Kweon, M. N. , Kiyono, H. and Yamamoto, M.
- Journal Title
  
  Infect Immun. 76
  
  Pages: 927-934
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249028
[Journal Article] Colonic patches direct the cross-talk between systemic compartments and large intestine independently of innate immunity.2008
- Author(s)
  Sun-Young Chang, Hye-Ran Cha, Uematsu, S., Akira, S., Igarashi, 0., Kiyono, H., and Mi-Na Kweon
- Journal Title
  
  J. Immunol. 180
  
  Pages: 1609-1618
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19059003
[Journal Article] The mucosa : at the frontlines of immunity.2008
- Author(s)
  Fehervaril, Z., and Kiyono, H.
- Journal Title
  
  Trends Immunol 29
  
  Pages: 503-504
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19059003
[Journal Article] Nasal Vaccination with the 40-Kilodalton outer membrane protein of Porphyromonas gingivalis and a nontoxic chimeric enterotoxin adjuvant induces lomg-term protective immunity with reduced levels of immunoglobulin E antibodies.2008
- Author(s)
  Momoi, F., Hashizume, T., Kurita-Ochiai, T., Yuki, Y., Kiyono, H ., and Yamamoto, M.
- Journal Title
  
  Infect Immun. 76
  
  Pages: 7840-7846
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249028
[Journal Article] Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFκB-inducing kinase in stromal cells.2008
- Author(s)
  Kunisawa, J., Gohda, M., Kurashima, Y., Ishikawa, I., Higuchi, M. and Kiyono, H.
- Journal Title
  
  Blood. 111
  
  Pages: 4646-4652
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19059003
[Journal Article] Nasal Vaccination with the 40-Kilodalton outer membrane protein of Porphyromonas gingivalis and a nontoxic chimeric enterotoxin adjuvant induces lomg-term protective immunity with reduced levels of immunoglobulin E antibodies.2008
- Author(s)
  Momoi, F., Hashizume, T., Kurita-Ochiai, T., Yuki, Y., Kiyono, H., and Yamamoto, M.
- Journal Title
  
  Infect Immun. 76
  
  Pages: 7840-7846
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19059003
[Journal Article] The mucosa: at the frontlines of immunity2008
- Author(s)
  Fehervari1, Z., and Kiyono, H
- Journal Title
  
  Trends Immunol
  
  Volume: 29 Pages: 503-504
- Data Source
  KAKENHI-PLANNED-19059003
[Journal Article] Comprehensive gene expression analysis among Peyer's patch M cells, villous M cells and intestinal epithelial cells by DNA microarray analysis2008
- Author(s)
  Terahara, K., Yoshida, M., Igarashi, O., Nochi, T., Pontes, GS., Hase, K., Ohno, H., Kurokawa, S., Mejima, M., Takayama, N., Yuki, Y., Lowe, AW. and Kiyono, H
- Journal Title
  
  J. Immunol
  
  Volume: 180 Pages: 7840-7846
- Data Source
  KAKENHI-PLANNED-19059003
[Journal Article] Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkB-inducing kinase in stromal cells.2008
- Author(s)
  Kunisawa, J., Gohda, M., Kurashima, Y., Ishikawa, I., Higuchi, M . and Kiyono, H.
- Journal Title
  
  Blood. 111
  
  Pages: 4646-4652
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249028
[Journal Article] Colonic patches direct the cross-talk between systemic compartments and large intestine independently of innate immunity.2008
- Author(s)
  Sun-Young Chang, Hye-Ran Cha, Uematsu, S., Akira, S., Igaras hi, O., Kiyono, H.,and Mi-Na Kweon
- Journal Title
  
  J. Immunol 180
  
  Pages: 1609-1618
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249028
[Journal Article] Comprehensive gene expression analysis among peyer's patch M cells, villous M cells and intestinal epithelial cells by DNA microarray analysis.2008
- Author(s)
  Terahara, T., Igarashi, O., Yoshid a, M., Nochi, T., Kurokawa, S.,Takayama, N., Yuki, Y., Low, A W. and Kiyono, H.
- Journal Title
  
  J. Immunol. 180
  
  Pages: 7840-7846
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249028
[Journal Article] Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5.2008
- Author(s)
  Uematsu, S., Fujimoto, K., Jang, MH., Yang, BG., Jung, YJ., Nishiyama, M., Sato, S., Tsujimura, T., Yamamoto, M., Yokota, Y., Kiyono, H., Miyasaka, M., Ishii, KJ., Akira, S.
- Journal Title
  
  Nat Immunol 9
  
  Pages: 769-776
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19059003
[Journal Article] Sphingosine 1-phosphate regulates the egress of IgA plasmablasts from Peyer's patches for intestinal IgA responses.2008
- Author(s)
  Gohda, M., Kunisawa, J., Miura, F., Kagiyama, Y., Kurashima, Y., Higuchi, M., Ishika wa, I., Ogahara, I. and Kiyono, H.
- Journal Title
  
  J. Immunol. 180
  
  Pages: 5335-5343
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19059003
[Journal Article] Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 52008
- Author(s)
  Uematsu, S., Fujimoto, K., Jang, MH., Yang, BG., Jung, YJ., Nishiyama, M., Sato, S., Tsujimura, T., Yamamoto, M., Yokota, Y., Kiyono, H., Miyasaka, M., Ishii, KJ., and Akira, S
- Journal Title
  
  Nature Immunol
  
  Volume: 9 Pages: 769-776
- Data Source
  KAKENHI-PLANNED-19059003
[Journal Article] Immunological commonalities and distinctions between airway and digestive immunity.2008
- Author(s)
  Kunisawa, J., Nochi, T. and Kiyono, H.
- Journal Title
  
  Trends Immunol. 29
  
  Pages: 505-513
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19059003
[Journal Article] Immunological commonalities and distinctions between airway and digestive immunity.2008
- Author(s)
  Kunisawa, J., Nochi, T. and Kiyono, H.
- Journal Title
  
  Trends Immunol. 29
  
  Pages: 505-513
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249028
[Journal Article] Peyer's patches are required for intestinal IgA responses to Salmonella2008
- Author(s)
  Hashizume, T., Togawa, A., Nochi, T., Igarashi, O., Kweon, MN., Kiyono, H. and Yamamoto, M
- Journal Title
  
  Infect. Immun
  
  Volume: 76 Pages: 927-934
- Data Source
  KAKENHI-PLANNED-19059003
[Journal Article] Cutting edge : Langerin+ dendritic cells in the mesenteric lymph node set the stage for skin and gut immune system cross-talk.2008
- Author(s)
  Chang, SY., Cha, HR., Igarashi, O., Rennert, PD., Kissenpfennig, A., Malissen, B., Nanno, M., Kiyono, H., and Kweon, MN.
- Journal Title
  
  J. Immunol. 180
  
  Pages: 4361-4365
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19059003
[Journal Article] Sphingosine 1-phosphate regulates the egress of IgA plasmablasts from Peyer's patches for intestinal IgA responses.2008
- Author(s)
  Gohda, M., Kunisawa, J., Miura, F., Kagiyama, Y., Kurashima, Y. , Higuchi, M., Ishikawa, I., Ogahara, I. and Kiyono, H.
- Journal Title
  
  J. Immunol. 180
  
  Pages: 5335-5343
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249028
[Journal Article] Tonic B cell activation by radioprotective105/MD-1 promotes diseaseprogression in MRL/lpr mice.2008
- Author(s)
  Kobayashi T, Takahashi K, Nagai Y, Shibata T, Otani M, Izui S, Akira S, Gotoh Y, Kiyono H, and Miyake K.
- Journal Title
  
  Int Immunol. 20
  
  Pages: 881-891
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19059003
[Journal Article] Peyer's patches are required for intestinal IgA responses to Salmonella.2008
- Author(s)
  Hashizume, T., Togawa, A., Nochi, T., Igarashi, O., Kweon, M.N., Kiyono, H. and Yamamoto, M.
- Journal Title
  
  Infect Immun. 76
  
  Pages: 927-934
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19059003
[Journal Article] Comprehensive gene expression analysis among peyer's patch M cells, villous M cells and intestinal epithelial cells by DNA microarray analysis.2008
- Author(s)
  Terahara, T., Igarashi, O., Yoshida, M., Nochi, T., Kurokawa, S., Takayama, N., Yuki, Y., Low, AW. and Kiyono, H.
- Journal Title
  
  J. Immunol. 180
  
  Pages: 7840-7846
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19059003
[Journal Article] Therapeutic effects of roxithromycin in Interleukin-10-deficient colitis2007
- Author(s)
  H.Tamagawa, T.Hiroi, T.Mizushima, T.Ito, H.Matsuda, H.Kiyono
- Journal Title
  
  Inflamm Bowel Dis (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591311
[Journal Article] Therapeutic effects of roxithromycin in Interleukin-10-deficient colitis.2007
- Author(s)
  H.Tamagawa, T.Hiroi, T.Mizushima, T.Ito, H.Matsuda, H.Kiyono
- Journal Title
  
  Inflamm Bowel Dis (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591311
[Journal Article] Production of a recombinant cholera toxin B subunit-insulin B chain peptide hybrid protein by Brevibacillus choshinensis expression system as a nasal vaccine against autoimmune diabetes.2005
- Author(s)
  Yuki, Y., Hara-Yakoyama, C., Guadiz, AA., Udak, S., Kiyono, H.
- Journal Title
  
  Biotechnol.Bioeng. 92
  
  Pages: 803-809
- Data Source
  KAKENHI-PROJECT-17047009
[Journal Article] A marvel of mucosal T cells and secretory antibodies for the creation of first lines of defense.2005
- Author(s)
  Kunisawa, J., Kiyono, H.
- Journal Title
  
  Cell Mol.Life Sci 62
  
  Pages: 1308-1321
- Data Source
  KAKENHI-PROJECT-17047009
[Journal Article] Prenatal blockage of lymphotoxin beta receptor and TNF receptor p55 signaling cascade resulted in the acceleration of tissue genesis for isolated lymphoid follicles in the large intestine.2005
- Author(s)
  Kweon, M.N., Yamamoto, M., Rennert, P.D., Park, E.J., Lee, A.Y., Chang, S.Y., Hiroi, T., Nanno, M., Kiyono, H
- Journal Title
  
  J.Immunol. 174
  
  Pages: 4365-4372
- Data Source
  KAKENHI-PROJECT-16017230
[Journal Article] A novel neurotoxoid vaccine prevents mucosal botulism.2005
- Author(s)
  Kobayashi, R., Kohda, T., Kataoka, K., Ihara, H., Kozaki, S., Pascual, DW., Staats, HF., Kiyono, H., McGhee, JR., Fujihashi K.
- Journal Title
  
  J.Immunol. 174
  
  Pages: 2190-2195
- Data Source
  KAKENHI-PROJECT-17047009
[Journal Article] Production of a recombinant cholera toxin B subunit-insulin B chain peptide hybrid protein by Brevibacillus choshinensis expression system as a nasal vaccine against autoimmune diabetes.2005
- Author(s)
  Yuki, Y., Hara-Yakoyama, C., Guadiz, AA., Udak, S., Kiyono, H.
- Journal Title
  
  Biotechnol.Bioeng. 92
  
  Pages: 803-809
- Data Source
  KAKENHI-PROJECT-16017230
[Journal Article] Mucosa-associated lymphoid tissues in the aerodigestive tract : their shared and divergent traits and their importance to the orchestration of the mucosal immune system.2005
- Author(s)
  Kunisaw, J., Fukuyama, S., Kiyono, H.
- Journal Title
  
  Curr.Mol.Med. 5
  
  Pages: 557-572
- Data Source
  KAKENHI-PROJECT-17047009
[Journal Article] Triggering of TLR3 by polyI:C in human corneal epithelial cells to induce inflammatory cytokines.2005
- Author(s)
  Ueta, M., Hamuro, J., Kiyono, H., Kinoshita, S.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 331
  
  Pages: 285-294
- Data Source
  KAKENHI-PROJECT-17047009
[Journal Article] A rice-based edible vaccine expressing multiple T cell epitopes induces oral tolerance for inhibition of Th-2 mediated IgE responses.2005
- Author(s)
  Takagi, H., Hiroi, H., Yang, L., Tada, Y., Yuki, Y., Takamura, K., Ishimitsu, R., Kawauchi, H., Kiyono, H., Takaiwa, F.
- Journal Title
  
  Proc.Nat.Acad.Sci.USA. 102
  
  Pages: 17525-17530
- Data Source
  KAKENHI-PROJECT-17047009
[Journal Article] Nontoxic Shiga toxin derivatives from Escherichia coli possess adjuvant activity for the augmentation of antigen-specific immune responses via dendritic cell activation.2005
- Author(s)
  Ohmura, M., Yamamoto, M., Tomiyama-Miyaji, C., Yuki, Y., Takeda, Y., Kiyono, H.
- Journal Title
  
  Infect.Immun. 73
  
  Pages: 4088-4097
- Data Source
  KAKENHI-PROJECT-16017230
[Journal Article] Mucosa-associated lymphoid tissues in the aerodigestive tract : their shared and divergent traits and their importance to the orchestration of the mucosal immune system.2005
- Author(s)
  Kunisaw, J., Fukuyama, S., Kiyono, H.
- Journal Title
  
  Curr.Mol.Med. 5
  
  Pages: 557-572
- Data Source
  KAKENHI-PROJECT-16017230
[Journal Article] A novel neurotoxoid vaccine prevents mucosal botulism.2005
- Author(s)
  Kobayashi, R., Kohda, T., Kataoka, K., Ihara, H., Kozaki, S., Pascual, DW., Staats, HF., Kiyono, H., McGhee, JR., Fujihashi, K.
- Journal Title
  
  J.Immunol. 174
  
  Pages: 2190-2195
- Data Source
  KAKENHI-PROJECT-16017230
[Journal Article] Intestinal gamma delta T cells develop in mice lacking thymus, all lymph nodes, Peyer's patches, and isolated lymphoid follicles.2005
- Author(s)
  Nonaka, S., Naito, T., Chen, H., Yamamoto, M., Moro, K., Kiyono, H.
- Journal Title
  
  J.Immunol. 174
  
  Pages: 1906-1912
- Data Source
  KAKENHI-PROJECT-17047009
[Journal Article] A marvel of mucosal T cells and secretory antibodies for the creation of first lines of defense.2005
- Author(s)
  Kunisawa, J., Kiyono, H.
- Journal Title
  
  Cell Mol.Life Sci 62
  
  Pages: 1308-1321
- Data Source
  KAKENHI-PROJECT-16017230
[Journal Article] Colitis in mice lacking the common cytokine receptor gamma chain is mediated by IL-6-producing CD4+T cells.2005
- Author(s)
  Kai, Y., Takahashi, I., Ishikawa, H., Hiroi, T., Mizushima, T., Matsuda, C., Kishi, D., Hamada, H., Tamagawa, H., Ito, T., Yoshizaki, K., Kishimoto, T., Matsuda, H., Kiyono, H.
- Journal Title
  
  Gastroenterology. 128
  
  Pages: 922-934
- Data Source
  KAKENHI-PROJECT-16017230
[Journal Article] Colitis in mice lacking the common cytokine receptor gamma chain is mediated by IL-6-producing CD4+ T cells.2005
- Author(s)
  Kai, Y., Takahashi, I., Ishikawa, H., Hiroi, T., Mizushima, T., Matsuda, C., Kishi, D., Hamada, H., Tamagawa, H., Ito, T., Yoshizaki, K., Kishimoto, T., Matsuda, H., Kiyono, H.
- Journal Title
  
  Gastroenterology. 128
  
  Pages: 922-934
- Data Source
  KAKENHI-PROJECT-17047009
[Journal Article] A rice-based edible vaccine expressing multiple T cell epitopes induces oral tolerance for inhibition of Th-2 mediated IgE responses.2005
- Author(s)
  Takagi, H., Hiroi, H., Yang, L., Tada, Y., Yuki, Y., Takamura, K., Ishimitsu, R., Kawauchi, H., Kiyono, H., Takaiwa, F.
- Journal Title
  
  Proc.Nat.Acad.Sci.USA. 102
  
  Pages: 17525-17530
- Data Source
  KAKENHI-PROJECT-16017230
[Journal Article] Intestinal gamma delta T cells develop in mice lacking thymus, all lymph nodes, Peyer's patches, and isolated lymphoid follicles.2005
- Author(s)
  Nonaka, S., Naito, T., Chen, H., Yamamoto, M., Moro, K., Kiyono, H.
- Journal Title
  
  J.Immunol. 174
  
  Pages: 1906-1912
- Data Source
  KAKENHI-PROJECT-16017230
[Journal Article] Nontoxic Shiga toxin derivatives from Escherichia coli possess adjuvant activity for the augmentation of antigen-specific immune responses via dendritic cell activation.2005
- Author(s)
  Ohmura, M., Yamamoto, M., Tomiyama -Miyaji, C., Yuki, Y., Takeda, Y., Kiyono, H.
- Journal Title
  
  Infect.Immun. 73
  
  Pages: 4088-4097
- Data Source
  KAKENHI-PROJECT-17047009
[Journal Article] Triggering of TLR3 by polyI:C in human corneal epithelial cells to induce inflammatory cytokines.2005
- Author(s)
  Ueta, M., Hamuro, J., Kiyono, H., Kinoshita, S.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 331
  
  Pages: 285-294
- Data Source
  KAKENHI-PROJECT-16017230
[Journal Article] Prenatal blockage of lymphotoxin beta receptor and TNF receptor p55 signaling cascade resulted in the acceleration of tissue genesis for isolated lymphoid follicles in the large intestine.2005
- Author(s)
  Kweon, M.N., Yamamoto, M., Rennert, P.D., Park, E.J., Lee, A.Y., Chang, S.Y., Hiroi, T., Nanno, M., Kiyono, H
- Journal Title
  
  J.Immunol. 174
  
  Pages: 4365-4372
- Data Source
  KAKENHI-PROJECT-17047009
[Journal Article] Nalt-versus peyer' s patch-mediated mucosal imunity.2004
- Author(s)
  Kiyono, H., Fukuyama S.
- Journal Title
  
  Nature Reviews Immunology 4
  
  Pages: 699-710
- Data Source
  KAKENHI-PROJECT-16017230
[Journal Article] Nalt-versus peyer' s-patch-mediated mucosal immunity2004
- Author(s)
  Kiyono, H., Fukuyama, S.
- Journal Title
  
  Nature Reviews Immunology 4
  
  Pages: 699-710
- Data Source
  KAKENHI-PROJECT-16043214
[Journal Article] Peyer's patches play a protective role in non-steroidal anti-inflammatory drug-induced enteropathy in mice
- Author(s)
  Hiyama S, Iijima H, Shinzaki S, Inoue T, Shiraishi E, Kawai S, Araki M, Kato M, Hayashi Y, Nishida T, Fujii H, Mukai A, Shibata N, Sato S, Kiyono H, Gotoh K, Motooka D, Nakamura S, Iida T, Tsujii M, Takehara T
- Journal Title
  
  Inflamm Bowel Dis
  
  Volume: (In press)
- Data Source
  KAKENHI-PROJECT-23590941
[Patent] 炎症性腸疾患の検査方法及び検査用キット2010
- Inventor(s)
  清野宏, 佐藤慎太郎, 小幡高士, 飯島英樹
- Industrial Property Rights Holder
  清野宏, 佐藤慎太郎, 小幡高士, 飯島英樹
- Industrial Property Number
  2010-072790
- Filing Date
  2010-03-26
- Data Source
  KAKENHI-PROJECT-20249028
[Presentation] 腸管マルチエコシステムによる炎症制御2017
- Author(s)
  Kiyono, H.
- Organizer
  The 17th Symposium on Japanese Society for Pediatoric Inflammatory Bowel Disease
- Place of Presentation
  Osaka, Japan
- Year and Date
  2017-02-05
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] コメ型経口ワクチンMucoRice開発プロジェクト2017
- Author(s)
  Kiyono H.
- Organizer
  Joint Symposium of The University of Tokyo and Institute of Industrial Science, Activities lead by NY Office,
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2017-01-20
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] Uniqueness of Mucosa-associated Lymphoid Tissues for Clinical Application2016
- Author(s)
  Kiyono H.
- Organizer
  The 40th Annual Meeting of the Japanese Society of Lymphology
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2016-06-25
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] カチオン化ナノゲルデリバリーシステムを用いた次世代型経鼻ワクチンの開発2016
- Author(s)
  Kiyono H.
- Organizer
  The 20th Annual meeting of the Japanese Society for Vaccinology
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2016-10-22
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] Intenstinal M cells contribute to maintenance of gut immune homeostasis2016
- Author(s)
  Kiyono H.
- Organizer
  The 45th Annual Meeting of The Japanese Society for Immunology
- Place of Presentation
  Okinawa, Japan
- Year and Date
  2016-12-05
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] Cutting Edge of Mucosal Immunology and Its Clinical Application2016
- Author(s)
  Kiyono H.
- Organizer
  International Symposium on Recent Advances in Rhinosinusitis and Nasal Polyposis
- Place of Presentation
  Kuara Lumpur, Malaysia
- Year and Date
  2016-11-21
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] ガーナにおける感染症サーベイランス体制強化とコレラ菌・HIVなどの腸管粘膜感染防御に関する研究2016
- Author(s)
  Kiyono H.
- Organizer
  Japan Agency for Medical Research and Development’s　革新的医療技術創出拠点project Symposium
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2016-12-19
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] 粘膜免疫の最新情報と炎症性疾患の制御に向けた経粘膜治療戦略2016
- Author(s)
  Kiyono H.
- Organizer
  The 29th Annual Meeting of Japan Society of Stomata-pharyngology
- Place of Presentation
  Matsue-shi, Shimane-ken
- Year and Date
  2016-09-08
- Invited
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] Mucosal Multi-ecosystem for the Induction and Regulation of Symbiosis and Protection2016
- Author(s)
  Kiyono H.
- Organizer
  The 60th Annual General Assembly and Scientific Meeting of the Japan Colleage of Rheumatology.
- Place of Presentation
  Yokohama, Japan
- Year and Date
  2016-04-23
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] Innate lymphoid cell and T cell synchronously regulate gut epithelial cell fucosylation2016
- Author(s)
  Kiyono H.
- Organizer
  The 10th International Symposium on Glycosyltransferases
- Place of Presentation
  Toronto, Canada
- Year and Date
  2016-06-19
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] MucoRice and NanoGel: New Generation of Mucosal Vaccines for Aero-digestive Infectious Diseases2016
- Author(s)
  Kiyono H.
- Organizer
  HWASUN International Vaccine Forum
- Place of Presentation
  Hwasun, Korea
- Year and Date
  2016-06-10
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] Regulation of Epithelial Clycosylation by Mucosal Immunity and Gut Microbiota2016
- Author(s)
  Kiyono H.
- Organizer
  The 23rd General meeting of the Japanese Association for Dental Science
- Place of Presentation
  Fukuoka, Japan
- Year and Date
  2016-10-23
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] Epithelial Cells-Innate Lymphoid Cells-Th Cells Trio-regulation for Gut Homeostasis and Inflammation2016
- Author(s)
  Kiyono H.
- Organizer
  The 4th Annual Meeting of the International Cytokine and Interferon Society
- Place of Presentation
  San Francisco, USA
- Year and Date
  2016-10-18
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] Epithlial Cells-Innate Lymphoid Cells-T Cells Trio-regulation for Gut homeostasis and Inflammation2016
- Author(s)
  Kiyono H.
- Organizer
  International Cytokine & Interferon Society, ICIS Cytokines 2016
- Place of Presentation
  San Francisco, USA
- Year and Date
  2016-10-18
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] “Mucosal Innate Lymphoid Cells and Mast Cells for the Regulation of Symbiosis and Inflammation”2015
- Author(s)
  Kiyono, H.
- Organizer
  World Immune Regulation Meeting IX
- Place of Presentation
  Davos, Switzerland.
- Year and Date
  2015-03-21
- Invited
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] “The Mucosal Immune System for Symbiosis and Elimination”2015
- Author(s)
  Kiyono, H.
- Organizer
  The 34th Shirokane Symposium, The 50th Anniversary of Founding of the Kitasato University School of pharmacy
- Place of Presentation
  Tokyo, Japan.
- Year and Date
  2015-02-28
- Invited
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] “Mucosal Immunity: The Adaptation of oral-Digestive Immune System for Vaccine Development”2015
- Author(s)
  Kiyono, H.
- Organizer
  The 3rd Medical Advisor Workshop, The Academy of Clinical Dentistry
- Place of Presentation
  Tokyo, Japan.
- Year and Date
  2015-02-11
- Invited
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] “Innovative Oral Vaccine：MucoRice”2015
- Author(s)
  Kiyono, H.
- Organizer
  “2015 Seminar for the Quality and Safety Improvements of Dental Practice” Kanagawa Dental Association
- Place of Presentation
  Kanagawa, Japan.
- Year and Date
  2015-03-08
- Invited
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] “Advancing the Knowledge of Immunology for Disease Treatments.”2015
- Author(s)
  Kiyono, H.
- Organizer
  Science Council of Japan and The Pharmaceutical Society of Japan Symposium
- Place of Presentation
  Tokyo, Japan.
- Year and Date
  2015-01-09
- Invited
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] "Mucosal Connections Between Airway and Reproductive Immunity"2014
- Author(s)
  Kiyono, H.
- Organizer
  10th Research Symposium on Human Natural Defense System in Conjunction with PRAMS 2014 in Commemoration of the 10th Anniversary of The Airway Mucus Institute
- Place of Presentation
  Seoul, Korea
- Year and Date
  2014-10-18
- Invited
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] “Mucosal Links between Innate-epithelial Cells and Commensal Flora for the Development of New Immune-prevention and -therapy”2014
- Author(s)
  Kiyono, H.
- Organizer
  2nd Novo Nordisk Innovation Summit 2014
- Place of Presentation
  Tokyo, Japan.
- Year and Date
  2014-10-01
- Invited
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] “Rice Protein Body and Cationic Nanogel as Antigen Delivery Vehicle for Mucosal Vaccines”2014
- Author(s)
  Kiyono, H.
- Organizer
  8th International Symposium on Nanomedicine (ISNM2014)
- Place of Presentation
  Matsuyama, Ehime.
- Year and Date
  2014-12-06
- Invited
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] “Oral Vaccine, MucoRice Fighting against the Diarrhea”2014
- Author(s)
  Kiyono, H.
- Organizer
  JSI organized Public Lecture Series Meneki Fushigi Mirai 2014.
- Place of Presentation
  Tokyo, Japan.
- Year and Date
  2014-08-10
- Invited
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] “Mucosal Innate Immune System and Vaccine Development”2014
- Author(s)
  Kiyono, H.
- Organizer
  The 1st International Symposium on Mucosal Immunity and Vaccine Development 2014.
- Place of Presentation
  Tokyo, Japan.
- Year and Date
  2014-10-21
- Invited
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] “Can We Prevent Infectious Diseases by Rice?”2014
- Author(s)
  Kiyono, H.
- Organizer
  Seminar for Knowledge of Hub, National University Joint Usage-Research Center
- Place of Presentation
  Tokyo, Japan.
- Year and Date
  2014-04-18
- Invited
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] “Innate Lymphoid Cells Regulate Intestinal Epithelial Cell Fucosylation for Symbiosis and Elimination”2014
- Author(s)
  Kiyono, H.
- Organizer
  The 26th Symposium on Microbial Sciences ~The Symphony of Microbial Science and Medical care~
- Place of Presentation
  Tokyo, Japan.
- Year and Date
  2014-09-19
- Invited
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] “Microbial Molding of Mucosal Immunity”2014
- Author(s)
  Kiyono, H.
- Organizer
  ACR/ARHP Annual Meeting
- Place of Presentation
  Boston, USA.
- Year and Date
  2014-11-14
- Invited
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] “Development of Mucosal Immunology Driven Rice-based Vaccine “MucoRice” by the Fusion Research of Medical, Agricultural and Engineering Sciences”2014
- Author(s)
  Kiyono, H.
- Organizer
  The 13th Shikoku Immunology Forum 2014
- Place of Presentation
  Tokushima, Japan.
- Year and Date
  2014-06-21
- Invited
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] “Cross-talk between the Mucosal Immune System and Environmental Factors”2014
- Author(s)
  Kiyono, H.
- Organizer
  11th Nestlé International Nutrition Symposium on “Nutrition and the Human Gut Microbiome”
- Place of Presentation
  Lausanne, Switzerland.
- Year and Date
  2014-10-23
- Invited
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] “Mucosal Connections between Microbial Ecology and Immunity for the Homeostasis and Inflammatory Responses”2014
- Author(s)
  Kiyono, H.
- Organizer
  7th International Immunonutrition Workshop -Eating for Preventing-
- Place of Presentation
  Carovigno, Italy.
- Year and Date
  2014-05-01
- Invited
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] ”Fusion of Medical, Plant and Engineering Science Led to the Creation of Rice-based Vaccine, MucoRice”2014
- Author(s)
  Kiyono, H.
- Organizer
  SKIL Future Forum -Science Leads to Safe Life-
- Place of Presentation
  Tokyo, Japan.
- Year and Date
  2014-04-18
- Invited
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] “Rice-based Oral Vaccine “MucoRice” for the Control of Enteric Diarrheal Disease”2014
- Author(s)
  Kiyono, H.
- Organizer
  The 62nd Annual Meeting of the Japanese Society for Virology
- Place of Presentation
  Yokohama, Japan
- Year and Date
  2014-11-10
- Invited
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] “Trends in Immunological Memory and Vaccine Development”, Organizer and Speaker, “Mucosal Immunity and Vaccine Development”2014
- Author(s)
  Kiyono, H.
- Organizer
  The 2nd Symposium of International Immunological Memory and Vaccine Forum, (IIMVF)
- Place of Presentation
  La Jolla, USA.
- Year and Date
  2014-08-26
- Invited
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] “Development of Next Generation Vaccine based on Mucosal Immunology~Future of Mucosal Vaccine”2014
- Author(s)
  Kiyono, H.
- Organizer
  The 65th Kanto Region Otorhinolaryngology Allergy Discussion Group
- Place of Presentation
  Tokyo, Japan.
- Year and Date
  2014-09-21
- Invited
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] The Intestinal Immune System for Mucosal Connections of Immunity, Commensal Microbiota and Vaccine2013
- Author(s)
  Kiyono, H.
- Organizer
  2013 Joint Meeting of the 13th Aaian Pan-pacific Society for Pediatric Gastroenterology, Hepatology and Nuritutionand the 40th Japanese Society for Pediatric Gastroenterology, Hepatology and Nutrition
- Place of Presentation
  Tokyo, Japan.
- Invited
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] Reverse Control of ATP-P2X7-dependent Mast Cells in Mucosa and Skin for Inflammation2013
- Author(s)
  Kiyono, H.
- Organizer
  Annual Meeting of the French Society for Immunology
- Place of Presentation
  Paris, France.
- Invited
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] Mucosal Connection for Immunity, Tolerance and Commensal Microbiota2013
- Author(s)
  Kiyono, H.
- Organizer
  JSPS: France-Japan Joint Forum “Frontiers inInnate Immunity”
- Place of Presentation
  Strasbourg, France.
- Invited
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] Immunological Interventions and Vaccine Development for the Elderly2013
- Author(s)
  Kiyono, H.
- Organizer
  ICI 15th Satellite Symposium “Aging and the Immune System”
- Place of Presentation
  Milan, Italy.
- Invited
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] Peyer's patches play a protective role in NSAIDs-induced small bowel injury2013
- Author(s)
  Hiyama, S., Iijima, H., Shinzaki, S., Shibata, N., Sato S., Tsujii, M., Kiyono, H., Takehara, T
- Organizer
  第42回日本免疫学会
- Place of Presentation
  幕張メッセ
- Data Source
  KAKENHI-PROJECT-23590941
[Presentation] The Mucosal immune system for New Generation of Prophylaxis and Therapeutic Nasal and Oral vaccines2013
- Author(s)
  Kiyono, H.
- Organizer
  The 7th International Symposium on Recent Advances in Rhinosinusitis and Nasal Polyposis
- Place of Presentation
  Shimane, Japan.
- Invited
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] The Intestinal Microbiota for Mucosal Decision of Immunity and Tolerance2013
- Author(s)
  Kiyono, H.
- Organizer
  International Yakult Symposium 2013 on “The Intestinal Microbiota and Probiotics: Exploiting Their Influence on Health”
- Place of Presentation
  London, UK.
- Invited
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] Immune Regulation and Monitoring at the Epithelial Surface of the Intestine2013
- Author(s)
  Kiyono, H.
- Organizer
  Fondation Mérieux: Targeting Commensal Flora to Better Shape Protective Immune Responses for Better Disease Prevention and Therapy
- Place of Presentation
  Annucy, France.
- Invited
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] MucoRice System for New Generation of Prophylaxis and Therapeutic Oral Vaccine2013
- Author(s)
  Kiyono, H.
- Organizer
  The 7th Vaccine & ISV Congress
- Place of Presentation
  Barcelona, Spain.
- Invited
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] Chaperon-Like Antigen Presentaion by Nanogel-Based Vaccine at Nasal Epithelium.2011
- Author(s)
  KIYONO H.
- Organizer
  Avison Biomedical Symposium 2011
- Place of Presentation
  Seoul, Korea
- Year and Date
  2011-02-25
- Data Source
  KAKENHI-PROJECT-20249028
[Presentation] Chaperon-Like Antigen Presentaion by Nanogel-Based Vaccine at Nasal Epithelium2011
- Author(s)
  HIROSHI KIYONO
- Organizer
  Avison Biomedical Symposium 2011
- Place of Presentation
  Seoul, Korea
- Year and Date
  2011-02-25
- Data Source
  KAKENHI-PLANNED-19059003
[Presentation] Chaperon-Like Antigen Presentaion by Nanogel-Based Vaccine at Nasal Epithelium2011
- Author(s)
  HIROSHI KIYONO
- Organizer
  Avison Biomedical Symposium 2011
- Place of Presentation
  Seoul, Korea
- Year and Date
  2011-02-25
- Data Source
  KAKENHI-PROJECT-20249028
[Presentation] Mucosal chaperoning nanogel vaccine for the induction of protective immunity.2010
- Author(s)
  KIYONO H.
- Organizer
  The 10^<th> Awaji International Forum on Infection and Immunity (United states-Japan Cooperative Medical Science Program 23rd Joint Meeting of the AIDS Panels.
- Place of Presentation
  Awaji, Japan
- Year and Date
  2010-09-08
- Data Source
  KAKENHI-PROJECT-20249028
[Presentation] Basic principals of immune responces: innate versus adaptive immunity.2010
- Author(s)
  KIYONO H.
- Organizer
  The 10^<th> International Advanced Course on Vaccinology in Asia Pacific Region.
- Place of Presentation
  Seoul, Korea
- Year and Date
  2010-05-10
- Data Source
  KAKENHI-PROJECT-20249028
[Presentation] Intra-tissue habitation of intestinal opportunistic bacteria in mammalian gut-associated lymphoid tissues for the creation of a mucosal antibody-mediated symiosis2010
- Author(s)
  HIROSHI KIYONO
- Organizer
  40^<th> Annual Meeting DGFI German Society for Immunology
- Place of Presentation
  Leipzig, Germany
- Year and Date
  2010-09-26
- Data Source
  KAKENHI-PLANNED-19059003
[Presentation] Basic principals of immune responces : innate versus adaptive immunity2010
- Author(s)
  HIROSHI KIYONO
- Organizer
  The 10^<th> International Advanced Course on Vaccinology in Asia Pacific Region
- Place of Presentation
  Seoul, Korea
- Year and Date
  2010-05-10
- Data Source
  KAKENHI-PLANNED-19059003
[Presentation] Craniofacial Mucosal Immune Sysem : Uniqueness of lymphoid Organogenesis and Immunological Function for NALT and TALT2010
- Author(s)
  HIROSHI KIYONO
- Organizer
  The 7^<th> Intenational Symposium on Tonsils and Mucosal Barriers of the Upper Airways
- Place of Presentation
  Asahikawa, Hokkaido旭川グランドホテル
- Year and Date
  2010-07-08
- Data Source
  KAKENHI-PLANNED-19059003
[Presentation] Basic principals of immune responces : innate versus adaptive immunity2010
- Author(s)
  HIROSHI KIYONO
- Organizer
  The 10^<th> International Advanced Course on Vaccinology in Asia Pacific Region
- Place of Presentation
  Seoul, Korea
- Year and Date
  2010-05-10
- Data Source
  KAKENHI-PROJECT-20249028
[Presentation] Mucosal Immunity in the Control of Infectious Diseases.2010
- Author(s)
  KIYONO H
- Organizer
  Pasteur-Areva Course Anti-Viral Imjmunity
- Place of Presentation
  Shanghai., China
- Year and Date
  2010-05-28
- Data Source
  KAKENHI-PROJECT-20249028
[Presentation] Role of Intestinal Glycosylation for the Mucosal Immne System and Mucosal Vaccine Development2010
- Author(s)
  HIROSHI KIYONO
- Organizer
  1^<st> Asia Pacific Workshop on Neurovirology Seoul 2010
- Place of Presentation
  Seoul, Korea.
- Year and Date
  2010-07-16
- Data Source
  KAKENHI-PROJECT-20249028
[Presentation] Intra-tissue habitation of intestinal opportunistic bacteria in mammalian gut-associated lymphoid tissues for the creation of a mucosal antibody-mediated symiosis2010
- Author(s)
  HIROSHI KIYONO
- Organizer
  40^<th> Annual Meeting DGFI German Society for Immunology
- Place of Presentation
  Leipzig, Germany
- Year and Date
  2010-09-26
- Data Source
  KAKENHI-PROJECT-20249028
[Presentation] Mucosal Nanogel-based Chaperon Vaccine for the induction of protective immunity2010
- Author(s)
  HIROSHI KIYONO
- Organizer
  4^<th> Vaccine and ISV Annual Global Congres
- Place of Presentation
  Vienna, Austria
- Year and Date
  2010-10-04
- Data Source
  KAKENHI-PROJECT-20249028
[Presentation] Intra-Tissue habitation of commensal bacteria in Peyer's patches for gut immunity.2010
- Author(s)
  KIYONO H.
- Organizer
  8^<th> German-Japanease Symposium, Regulation of immune response and diseases.
- Place of Presentation
  Cuxhahen, Germany
- Year and Date
  2010-09-27
- Data Source
  KAKENHI-PROJECT-20249028
[Presentation] New Prospects on the Aerodigestive Immunity for Mucosal Vactine Development2010
- Author(s)
  HIROSHI KIYONO
- Organizer
  Prato Conference on the Pathogenesis of Bacterial Diseasesof Animals
- Place of Presentation
  Prato, Italy
- Year and Date
  2010-10-09
- Data Source
  KAKENHI-PROJECT-20249028
[Presentation] Intra-Tissue habitation of commensal bacteria in Peyer's patches for gut immunity2010
- Author(s)
  HIROSHI KIYONO
- Organizer
  8^<th> German-Japanease Symposium, Regulation of immune response and diseases
- Place of Presentation
  Cuxhahen, Germany.
- Year and Date
  2010-09-27
- Data Source
  KAKENHI-PLANNED-19059003
[Presentation] New Prospects on the Aerodigestive Immunity for Mucosal Vaccine Development2010
- Author(s)
  HIROSHI KIYONO
- Organizer
  Prato Conference on the Pathogenesis of Bacterial Diseases of Animals
- Place of Presentation
  Prato, Italy
- Year and Date
  2010-10-09
- Data Source
  KAKENHI-PLANNED-19059003
[Presentation] Mucosal Nanogel-based Chaperon Vaccine for the induction of protective immunity.2010
- Author(s)
  KIYONO H.
- Organizer
  4^<th> Vaccine and ISV Annual Global Congress.
- Place of Presentation
  Vienna, Austria
- Year and Date
  2010-10-04
- Data Source
  KAKENHI-PROJECT-20249028
[Presentation] Novel Strategy for Mucosal Vaccine Development : MucoRice and MucoNanogel2010
- Author(s)
  清野宏
- Organizer
  Adaptive and Innate Immune Resposes to Neglected Tropical Disease Conference
- Place of Presentation
  SanDiego, USA
- Year and Date
  2010-01-10
- Data Source
  KAKENHI-PROJECT-20249028
[Presentation] Mucosal Immunity in the Control of Infectious Diseases2010
- Author(s)
  HIROSHI KIYONO
- Organizer
  Pasteur-Areva Course Anti-Viral Imjmunity
- Place of Presentation
  Shanghai, China
- Year and Date
  2010-05-28
- Data Source
  KAKENHI-PLANNED-19059003
[Presentation] Role of Intestinal Glycosylation for the Mucosal Immne System and Mucosal Vaccine Development.2010
- Author(s)
  KIYONO H.
- Organizer
  1^<st> Asia Pacific Workshop on Neurovirology Seoul 2010
- Place of Presentation
  Seoul, Korea
- Year and Date
  2010-07-16
- Data Source
  KAKENHI-PROJECT-20249028
[Presentation] Mucosal chaperoning nanogel vaccine for the induction of protective immunity2010
- Author(s)
  HIROSHI KIYONO
- Organizer
  The 10^<th> Awaji International Forum on Infection and Immunity (United states-Japan Cooperative Medical Science Program 23^<rd> Joint Meeting of the AIDS Panels
- Place of Presentation
  Awaji, Japan.淡路夢舞台国際会議場
- Year and Date
  2010-09-08
- Data Source
  KAKENHI-PLANNED-19059003
[Presentation] Novel Strategy for Mucosal Vaccine Development : MucoRice and MucoNanogel2010
- Author(s)
  清野宏
- Organizer
  Adaptive and Innate Immune Resposes to Neglected Tropical Disease Conference
- Place of Presentation
  SanDiego, USA
- Year and Date
  2010-01-10
- Data Source
  KAKENHI-PLANNED-19059003
[Presentation] Craniofacial Mucosal Immune Sysem : Uniqueness of lymphoid Organogenesis and Immunological Function for NALT and TALT.2010
- Author(s)
  KIYONO H.
- Organizer
  The 7^<th> Intenational Symposium on Tonsils and Mucosal Barriers of the Upper Airways
- Place of Presentation
  Asahikawa., Hokkaido
- Year and Date
  2010-07-08
- Data Source
  KAKENHI-PROJECT-20249028
[Presentation] New Prospects on the Aerodigestive Immunity for Mucosal Vaccine Development.2010
- Author(s)
  KIYONO H.
- Organizer
  Prato Conference on the Pathogenesis of Bacterial Diseasesof Animals.
- Place of Presentation
  Prato, Italy
- Year and Date
  2010-10-09
- Data Source
  KAKENHI-PROJECT-20249028
[Presentation] Craniofacial Mucosal Immune Sysem : Uniqueness of lymphoid Organogenesis and Immunological Function for NALT and TALT2010
- Author(s)
  HIROSHI KIYONO
- Organizer
  The 7^<th> Intenational Symposium on Tonsilsand Mucosal Barriers of the Upper Airways
- Place of Presentation
  Asahikawa Grand Hotel
- Year and Date
  2010-07-08
- Data Source
  KAKENHI-PROJECT-20249028
[Presentation] Mucosal Immunity in the Control of Infectious Diseases2010
- Author(s)
  HIROSHI KIYONO
- Organizer
  Pasteur-Areva Course Anti-Viral Imjmunity
- Place of Presentation
  Shanghai, China
- Year and Date
  2010-05-28
- Data Source
  KAKENHI-PROJECT-20249028
[Presentation] Mucosal Nanogel-based Chaperon Vaccine for the induction of protective immunity2010
- Author(s)
  HIROSHI KIYONO
- Organizer
  4^<th> Vaccine and ISV Annuals Global Congress
- Place of Presentation
  Vienna, Austria
- Year and Date
  2010-10-04
- Data Source
  KAKENHI-PLANNED-19059003
[Presentation] Intra-Tissue habitation of commensal bacteria in Peyer's patches for gut immunity2010
- Author(s)
  HIROSHI KIYONO
- Organizer
  8^<th> German-Japanease Symposium, Regulation of immune response and diseases
- Place of Presentation
  Cuxhahen, Germany
- Year and Date
  2010-09-27
- Data Source
  KAKENHI-PROJECT-20249028
[Presentation] New Prospect for Mucosal Vaccine Development : MucoRiceTM for Refrigeration-and Needle/Shiringe-free vaccine.2010
- Author(s)
  清野宏
- Organizer
  The 2nd International Symposium of Innovative Bioproduction Kobe (iBioK)
- Place of Presentation
  Kobe, Japan
- Year and Date
  2010-01-22
- Data Source
  KAKENHI-PROJECT-20249028
[Presentation] Mucosal chaperoning nanogel vaccine for the induction of protective immunity2010
- Author(s)
  HIROSHI KIYONO
- Organizer
  The 10^<th> Awaji Inteertional Forum on Infection and Immunity (United states-Japan Cooperative Medical Science Program 23^<rd> Joint Meeting of the AIDS Panels
- Place of Presentation
  Awaji, 淡路夢舞台国際会議場
- Year and Date
  2010-09-08
- Data Source
  KAKENHI-PROJECT-20249028
[Presentation] New Prospect for Mucosal Vaccine Development : MucoRiceTM for Refrigeration-and Needle/Shiringe-free vaccine2010
- Author(s)
  清野宏
- Organizer
  The 2nd International Symposium of Innovative B-ioproduction Kobe(iBioK)
- Place of Presentation
  Kobe, Japan
- Year and Date
  2010-01-22
- Data Source
  KAKENHI-PLANNED-19059003
[Presentation] Intra-tissue habitation of intestinal opportunistic bacteria in mammalian gut-associated lymphoid tissues for the creation of a mucosal antibody-mediated symbiosis.2010
- Author(s)
  KIYONO H.
- Organizer
  40^<th> Annual Meeting DGFI German Society for Immunology.
- Place of Presentation
  Leipzig, Germany
- Year and Date
  2010-09-26
- Data Source
  KAKENHI-PROJECT-20249028
[Presentation] Role of Intestinal Glycosylation for the Mucosal Immne System and Mucosal Vaccine Development2010
- Author(s)
  HIROSHI KIYONO
- Organizer
  1^<st> Asia Pacific Workshop on Neurovirology Seoul 2010
- Place of Presentation
  Seoul, Korea.
- Year and Date
  2010-07-16
- Data Source
  KAKENHI-PLANNED-19059003
[Presentation] Rice-Based Vaccine : New Generation of Mucosal Vacine2009
- Author(s)
  清野宏
- Organizer
  14th International Congress of Mucosal Immunology
- Place of Presentation
  Boston, USA
- Year and Date
  2009-07-08
- Data Source
  KAKENHI-PROJECT-20249028
[Presentation] Mucosal Immunity : A Driving Force for the Development of New Generation of Oral Vaccine2009
- Author(s)
  清野宏
- Organizer
  The 13th International Conference on Emerging Infection Dieseases of the Pacific Rum : Focus on Enteric Diseases.
- Place of Presentation
  Kolkata, India.
- Year and Date
  2009-04-06
- Data Source
  KAKENHI-PROJECT-20249028
[Presentation] 粘膜免疫による腸内細菌共生の構築2009
- Author(s)
  清野宏
- Organizer
  第91回日本消化器病学会中国支部例会
- Place of Presentation
  岡山, 日本
- Year and Date
  2009-06-13
- Data Source
  KAKENHI-PLANNED-19059003
[Presentation] The Craniofacial and Mucosal Immune System2009
- Author(s)
  清野宏
- Organizer
  Japanese Journal of Rhinology
- Place of Presentation
  島根, 日本
- Year and Date
  2009-10-03
- Data Source
  KAKENHI-PLANNED-19059003
[Presentation] Rice-Based Vaccine : New Generation of Mucosal Vacine2009
- Author(s)
  清野宏
- Organizer
  14th International Congress of Mucosal Immunol-ogy
- Place of Presentation
  Boston, USA.
- Year and Date
  2009-07-08
- Data Source
  KAKENHI-PLANNED-19059003
[Presentation] The Craniofacial and Mucosal Immune System2009
- Author(s)
  清野宏
- Organizer
  Japanese Journal of Rhinology
- Place of Presentation
  島根,日本
- Year and Date
  2009-10-03
- Data Source
  KAKENHI-PROJECT-20249028
[Presentation] New Prospect for Vaccine Development : MucoRice and MucoNanogel2009
- Author(s)
  清野宏
- Organizer
  3rd Vaccine Global Congress
- Place of Presentation
  Singapore Singapore
- Year and Date
  2009-10-04
- Data Source
  KAKENHI-PLANNED-19059003
[Presentation] Mucosal Decision of Immunity and Tolerance for Creation of Symbiosis2009
- Author(s)
  清野宏
- Organizer
  The 6th Extraordinary International Symposium on Recent Advances in Otitis Media
- Place of Presentation
  Seoul, Korea
- Year and Date
  2009-05-06
- Data Source
  KAKENHI-PROJECT-20249028
[Presentation] Sessionl "Id2, RORgt, and LTbR independent initiation of TALT genesis in ocular immunity." and Sessionl "Indigenous opportunistic bacteria inhabit mammalian gut associated lymphoid tissues for gut immunity."2009
- Author(s)
  清野宏
- Organizer
  Mucosal immunology Workshop at Trudeau Institute
- Place of Presentation
  New York, USA
- Data Source
  KAKENHI-PLANNED-19059003
[Presentation] 粘膜免疫による腸内細菌共生機構の構築2009
- Author(s)
  清野宏
- Organizer
  第63回日本細菌学会東北支部総会
- Place of Presentation
  盛岡,日本
- Year and Date
  2009-08-20
- Data Source
  KAKENHI-PROJECT-20249028
[Presentation] Mucosal Harmony for Immunity and Tolerance in Vaccine Development2009
- Author(s)
  清野宏
- Organizer
  2nd European Congress of Immunology
- Place of Presentation
  Berlin, Germany
- Year and Date
  2009-09-14
- Data Source
  KAKENHI-PROJECT-20249028
[Presentation] Mucosal Immunity : A Driving Force for the Development of New Generation of Oral Vaccine2009
- Author(s)
  清野宏
- Organizer
  The 13th International Conference on Emerging In fection Dieseases of the Pacific Rum : Focus on Enteric Diseases
- Place of Presentation
  Kolkata, India
- Year and Date
  2009-04-06
- Data Source
  KAKENHI-PLANNED-19059003
[Presentation] Session1"Id2, RORgt, and LTbR independent initiation of TALT genesis in ocular immunity."and Session2"Indigenous opportunistic bacteria inhabit mammalian gut associated lymphoid tissues for gut immunity."2009
- Author(s)
  清野宏
- Organizer
  Mucosal immunology Workshop at Trudeau Institute
- Place of Presentation
  New York, USA
- Data Source
  KAKENHI-PROJECT-20249028
[Presentation] Mucosal Harmony for Immunity and Tolerance in Vaccine Development2009
- Author(s)
  清野宏
- Organizer
  2nd European Congress of Immunology
- Place of Presentation
  Berlin, Germany
- Year and Date
  2009-09-14
- Data Source
  KAKENHI-PLANNED-19059003
[Presentation] 粘膜免疫による腸内細菌共生の構築2009
- Author(s)
  清野宏
- Organizer
  第91回日本消化器病学会中国支部例会
- Place of Presentation
  岡山,日本
- Year and Date
  2009-06-13
- Data Source
  KAKENHI-PROJECT-20249028
[Presentation] 粘膜免疫による腸内細菌共生機構の構築2009
- Author(s)
  清野宏
- Organizer
  第63回日本細菌学会東北支部総会
- Place of Presentation
  盛岡, 日本
- Year and Date
  2009-08-20
- Data Source
  KAKENHI-PLANNED-19059003
[Presentation] MucoRice : New Horizon for the Development of Oral Vaccine2009
- Author(s)
  清野宏
- Organizer
  12th Asia Pacific-International Molecular Biology Network(A-IMBN)Symposium
- Place of Presentation
  Penang, Malaysia
- Year and Date
  2009-10-27
- Data Source
  KAKENHI-PLANNED-19059003
[Presentation] Mucosal Decision of Immunity and Tolerance for Creation of Symbiosis2009
- Author(s)
  清野宏
- Organizer
  The 6th Extraordinary International Symposium on Recent Advances in Otitis Media
- Place of Presentation
  Seoul, Korea
- Year and Date
  2009-05-06
- Data Source
  KAKENHI-PLANNED-19059003
[Presentation] MucoRice : New Horizon for the Development of Oral Vaccine2009
- Author(s)
  清野宏
- Organizer
  12th Asia Pacific-International Molecular Biology Network (A-IMBN) Symposium
- Place of Presentation
  Penang, Malaysia
- Year and Date
  2009-10-27
- Data Source
  KAKENHI-PROJECT-20249028
[Presentation] New Prospect for Vaccine Development : MucoRice and MucoNanogel2009
- Author(s)
  清野宏
- Organizer
  3rd Vaccine Global Congress
- Place of Presentation
  Singapore
- Year and Date
  2009-10-04
- Data Source
  KAKENHI-PROJECT-20249028
[Presentation] Spick-and-Span for the Development of MucoRice and Nanoantibody for the Control of Viral and Bacterial Infection
- Author(s)
  Kiyono, H
- Organizer
  25th Annual Meeting of the Japanese Society for AIDS Research, International Symposium on “HIV and Mucosal Immunity”
- Place of Presentation
  東京、ハイアットリージェンシー東京
- Invited
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] Spick-and-Span in Mucosal Immunity: From Homeostasis to Vaccine Development
- Author(s)
  Kiyono, H
- Organizer
  Todai International Forum 2011 System Biology and Genomic Medicine Forum
- Place of Presentation
  Paris, France
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] Mucosal Chaperoning Vaccines for Upper Respiratory Tract Infections
- Author(s)
  Kiyono, H
- Organizer
  The 14th International Rhinologic Society and 30th International Symposium on Infection and Allergy of the Nose
- Place of Presentation
  東京、ANAインターコンチネンタル東京
- Invited
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] Resistance to helminthic infection is dependent on mast cell activation mediated by ATP in Spi-B-deficient mice.
- Author(s)
  Shimokawa, C., Kanaya, T., Ishikawa, K., Kurashima Y., Kiyono, H., Kaisho T. and Ohno, H.
- Organizer
  The 43rd Annual Meeting of The Japanese Society for Immunology, Kyoto
- Place of Presentation
  Kyoto, Japan.
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] Mucosal integrated immunological seesaw between mutualization and elimination in the intestine
- Author(s)
  Kiyono, H
- Organizer
  The 19th East Asia Joint Symposium on Biomedical Research "Moleculer Understanding for Physiology and Pathology."
- Place of Presentation
  Seoul, Korea
- Invited
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] Critical role of TSLP-TSLPR interaction in inducing secretory IgA responses after mucosal immunizations.
- Author(s)
  Joo, S., Fukuyama, Y., Yuki Y., Kurashima, Y., Ziegler, S.F., Park E-J. and Kiyono, H.
- Organizer
  The 43rd Annual Meeting of The Japanese Society for Immunology
- Place of Presentation
  Kyoto, Japan.
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] Gut Microflora Influences Pathology in the Kawasaki Disease (KD) VasculitisMouse Model
- Author(s)
  Wakita, D., Kurashima, Y., Takasato, Y., Lee, Y., Shimada, K., Chen, S., Crother, T. R., Fishbein, M. C., Lehman, T.J.A., Kiyono, H., and Arditi , M.
- Organizer
  International Kawasaki Disease Symposium
- Place of Presentation
  Hawaii, USA.
- Year and Date
  2015-02-03 – 2015-02-06
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] MucoRice: Rice-based Oral Vaccine Development
- Author(s)
  Kiyono, H
- Organizer
  Molecular Immunology & Immunogenetics Congress 2012
- Place of Presentation
  Antalya, Turkey
- Invited
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] E-NPP3 (CD203c) negatively regulates ATP-dependent allergic responses by basophils and mast cells.
- Author(s)
  Tsai, S-H., Kinoshita, M., Kayama, H., Okuma, R., Kiyono, H., Karasuyama, H. and Takeda, K.
- Organizer
  The 43rd Annual Meeting of The Japanese Society for Immunology
- Place of Presentation
  Kyoto, Japan.
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] Vaginal resident memory T cells induced by intranasal vaccination are critical for early clearance of genital HSV-2 infection.
- Author(s)
  Suwanto, A., Sato A., Sato S., Nochi, T., Kunisawa, J. and Kiyono, H.
- Organizer
  The 43rd Annual Meeting of The Japanese Society for Immunology
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] Spick-and-span in mucosal vaccine development
- Author(s)
  Kiyono, H
- Organizer
  The 34th Naito Conference on Infection, Immunity and their Contral for Health: Mucosal Barrier, Pathogen and Vaccine
- Place of Presentation
  札幌、シャトレーゼガトーキングダムサッポロ
- Invited
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] Mucosal integreated immunological seesaw between physiological and pathological inflammation
- Author(s)
  Kiyono, H
- Organizer
  IEIIS 2012 Homeostatic Inflammation Symposium
- Place of Presentation
  東京、一橋記念講堂
- Invited
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] Spick-and-span in Mucosal Immunity: From Intestional Homeostasis to Vaccine Develipment
- Author(s)
  Kiyono, H
- Organizer
  A-IMBN Symposium
- Place of Presentation
  Jeju , Korea
- Invited
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] Loss of lymph node fibroblastic reticular cells and high endothelial cells underlies humoral immunodeficiency in mouse GVHD.
- Author(s)
  Ueha, S., Suenaga, F., Abe, J., Kosugi, M., Shono, Y., Kunisawa, J., Sato S., Kiyono, H. and Matsushima, K.
- Organizer
  The 43rd Annual Meeting of The Japanese Society for Immunology
- Place of Presentation
  Kyoto, Japan.
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] MucoRice: Fusion of Mucosal immunology and plant biology ked to the development of rice-based oral vaccine
- Author(s)
  Kiyono, H
- Organizer
  The 10th International Congress on Plant Molecular Biology
- Place of Presentation
  Jeju , Korea
- Invited
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] The Mucosal Gateway System for Antigen-sampling and Homestatic Niche.
- Author(s)
  Kiyono, H
- Organizer
  The 15th International Congress of Mucosal Immunology
- Place of Presentation
  Paris, France
- Invited
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] “Reciprocal Cooperation of Intra-tissue Commensal Bacteria, Innate Lymphoid Cells and Mast Cells for the Integrated Mucosal Immunoregulation”
- Author(s)
  Kiyono, H.
- Organizer
  The 38th Aso Symposium 2014.
- Place of Presentation
  Kumamoto, Japan.
- Year and Date
  2014-07-25 – 2014-07-26
- Invited
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] Spick and Span in Intestional Immunity: From Mucosal Homeostasis to Vaccine Development
- Author(s)
  Kiyono, H
- Organizer
  The 35th General Meeting of Turkish Society of Microbiology
- Place of Presentation
  Izmir, Turkey
- Invited
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] Mucosal Innate Immune System for Mutalisum, Inflammation and Elimination
- Author(s)
  Kiyono, H
- Organizer
  The 4th Microbial Pathogenesis & Immunity Symposium
- Place of Presentation
  Seoul, Korea
- Invited
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] Mucosal Decisions of Mutualisum and Elimination for Surface barrier system
- Author(s)
  Kiyono, H
- Organizer
  The 6th Annual International Symposium in Institute of Dermatological Science(IDS)
- Place of Presentation
  Seoul, Korea
- Invited
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] Mucosal Vaccine for the Control of Infectious Diseases
- Author(s)
  Kiyono, H
- Organizer
  STS International Forum 9th Annual Meeting
- Place of Presentation
  京都、国立京都国際会館
- Invited
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] Spick-and-Span for the Development of Transgenic-Rice (MucoRice) based Oral Vaccine
- Author(s)
  Kiyono, H
- Organizer
  International Union of Microbiological Societies 2011
- Place of Presentation
  札幌、札幌コンベンションセンター
- Invited
- Data Source
  KAKENHI-PROJECT-23229004
[Presentation] Mucosal Integration of Mutualism and Elimination for Surface barrier System
- Author(s)
  Kiyono, H
- Organizer
  International Meeting of the Microbioligical Society of Korea
- Place of Presentation
  Seoul, Korea
- Invited
- Data Source
  KAKENHI-PROJECT-23229004

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Kiyono Hiroshi 清野 宏

清野 宏 キヨノ ヒロシ

KIYONO Hiroshi 清野 宏

Research Projects

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消化管の階層的粘膜支持連関システムによる粘膜防御機構の解明Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Multi Regulatory System for Gut Homeostasis and InflammationPrincipal InvestigatorOngoing

Principal Investigator

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Immunological crosstalk between nasal and reproductive mucosal tissuePrincipal Investigator

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顎顔面免疫と生殖器免疫のクロストークPrincipal Investigator

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Analysis of antigen-uptake network at mucosal epithelial layerPrincipal Investigator

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Mucosal Immunology and self‐discriminationPrincipal Investigator

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粘膜免疫監視の場としてのGALT・NALTを介した免疫制御誘導の解明Principal Investigator

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エイズ粘膜ワクチン開発へ向けて:HIV特異的分泌型IgA誘導システムの開発Principal Investigator

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粘膜免疫監視の場としてのGALT・NALTを介した免疫制御誘導の解明Principal Investigator

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Kiyono Hiroshi 清野宏

清野宏キヨノヒロシ

KIYONO Hiroshi 清野宏