KISHIMOTO Tadamitsu 岸本忠三

Researcher Number	10093402
Other IDs
Affiliation (Current)	2021: 大阪大学, 免疫学フロンティア研究センター, 教授
Affiliation (based on the past Project Information) *help	2017: 大阪大学, 免疫学フロンティア研究センター, 教授 2014 – 2016: 大阪大学, 免疫学フロンティア研究センター, 特任教授 2002: 総長 2002: Osaka University, President, 総長 1999 – 2002: 大阪大学, 医学系研究科, 総長 … More
Review Section/Research Field	Principal Investigator Biological Sciences Except Principal Investigator Immunology / Orthopaedic surgery / Immunology / Biological Sciences / Pathological medical chemistry / Immunology / Immunology
Keywords	Principal Investigator サイトカイン / 自己免疫疾患 / インターロイキン6 / CD40 / IL-6 / NF-IL6 / IL-2レセプター / BSF2 / IL-5 / 急性期反応 … More Except Principal Investigator 免疫寛容 / 自己免疫疾患 / Arid5a / 免疫制御 / 免疫病 / リン酸化 / RNA結合タンパク質 / NMR / Biosensor / トランスジェニックマウス / 免疫応答 / MHC / サイトカイン / シグナル伝達 / cytokine / signal transduction / IL-6 / FasL / STAT / SSl-1 / Src / Lyn / RNA安定性制御 / osteoblast / transcription / osteoclast / cvtokine / osteoporosis / differention / RNA安定性 / ユビキチンプロテアソーム系 / NF-κB / MAPK / 転写後制御 / Immunology / interleukin-6 / mRNA Stability / トランスゲニックマウス / インターロイキン / 組みかえDNA / バイオテクノロジー / リンフォカイン / 免疫機能分子 / 自己認識 / 分裂酵母 / Cre-IoxP / 形態形成 / 高等植物 / 遺伝子標的 / 分子相互作用 / バイオセンサー / 免疫系 / ATPase / 温度感受性突然変異体 / 細胞周期 / DNA再複製 / バイオモニタリング / RNAプロセシング / 遺伝子ターゲティング / 蛋白高次機能構造 / 胚形成 / 植物 / Fission yeast / Cre-loxP / Morphogenesis / Higher plants / Gene targeting / Protein interaction / 総括班 / 情報提供 / 情報交換 / 国際シンポジウム / ジーンノックアウトマウス / immune regulation / immune tolerance / group of generalization / providing information / information exchanges / international symposium / transgenic mouse / gene knockout mouse / T細胞 / B細胞 / 発生工学 / ポリコ-ム遺伝子 / 水晶体特異的遺伝子発現 / 有機リン系農薬センサー / 転写因子 / T cell / Immunological tolerance / B cell / Transgenics / Polycomb genes / Crystallin gene / Transcriptional factor / CD40, CD40L / CD80, CD86 / HSI / CD95L / TCR / TGF-β / Smad / CD40 / アポトーシス / TCR-peptides / CD40-CD40L / TGF-beta / 抗原受容体 / 補助受容体 / 細胞分化 / 炎症疾患 / 免疫異常 / ノックアウトマウス / immune response / antigen receptor / co-receptor / cell differentiation / autoimmune disease / inflammation / 軟骨由来因子 / 軟骨由来抗腫瘍因子 / 線維芽細胞由来内皮細胞増殖因子 / エリスロポエチン様因子 / インスリン作用促進因子 / 血小板由来増殖阻害因子 / 腫瘍増殖促進因子 / Bリンパ球分化因子 / Cartilage-Derived Factor (CDF) / Cartilage-derived Anti-Tumor Factor (CATF) / Fibroblast-derived Endothelial Cell Growth Factor (f-ECGF) / Erythropoietin-like factor / Insulin-Stimulating Peptide (ISP) / Platelet-Derived Growth Inhibitor (PDGI) / Tumor Growth Stimulating Activity (TGSA) / Immune Regulation / Phosphorylation / Degradation / Ubiquitination / p38 MAPK / ユビキチン化 / タンパク質分解 / T細胞過剰活性化 / 転写後調節 / IL-6 mRNA / STAT分子 / Th17細胞 / Regnase-1 / インフルエンザ / 感染・炎症 / サイトカインストーム Less

ＭＡＰＫシグナルに関連したＡｒｉｄ５ａタンパク質分解機構の解明Host Researcher
- Host Researcher
  
  岸本忠三
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Research Field
  
  Immunology
- Research Institution
  Osaka University
The pathogenic role of Arid5a in infection and autoimmunity.
- Principal Investigator
  
  MASUDA Kazuya
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Osaka University
免疫細胞および自己免疫疾患のＩＬ－６　ｍＲＮＡ調節におけるＡｒｉｄ５ａの役割Host Researcher
- Host Researcher
  
  岸本忠三
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Research Field
  
  Immunology
- Research Institution
  Osaka University
Regulatory mechanism of signal transduction in the immune system.
- Principal Investigator
  
  HIRANO Toshio
- Project Period (FY)
  1999 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
感染症と免疫病の分子生物学と医学Principal Investigator
- Principal Investigator
  
  山西弘一, 岸本忠三
- Project Period (FY)
  1997 – 2003
- Research Category
  
  Grant-in-Aid for COE Research
- Research Institution
  Osaka University
Immune regulation and signal tranduction
- Principal Investigator
  
  OKUMURA Ko
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Immunology
- Research Institution
  Juntendo University School of Medicine
Regulation of Gene Expression
- Principal Investigator
  
  TANIGUCHI Masaru
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Chiba University, School of Medicine
Immune regulation and signal tranduction
- Principal Investigator
  
  OKUMURA Ko
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Juntendo University School of Medicine
骨粗鬆症の基礎に関する分子機構の研究動向の調査
- Principal Investigator
  
  野田政樹
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokyo Medical and Dental University
Regulation of Gene Expression
- Principal Investigator
  
  TANIGUCHI Masaru
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Chiba University
Studies on molecular mechanisms of autoimmune diseasesPrincipal Investigator
- Principal Investigator
  
  KISHIMOTO Tadamitsu
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Osaka University
免疫病の分子・遺伝子治療に関する研究Principal Investigator
- Principal Investigator
  
  KISHIMOTO Tadamitsu
- Project Period (FY)
  1993 – 1996
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Molecular mechanism of immune regulation and immune tolerance
- Principal Investigator
  
  SASAZUKI Takehiko
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
免疫制御・寛容の分子機構
- Principal Investigator
  
  SASAZUKI Takehiko
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Institution
  Kyushu University
Studies on the regulation of gene expression in lymphoid cells.Principal Investigator
- Principal Investigator
  
  KISHIMOTO Tadamitsu
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Osaka University
Studies on the regulation of gene expression in lymphoid cells.Principal Investigator
- Principal Investigator
  
  KISHIMOTO Tadamitsu
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Osaka University
Exchange of the informations in the cooperative immunology research between the US-Japan Bords.Principal Investigator
- Principal Investigator
  
  KISHIMOTO Tadamitsu
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Overseas Scientific Survey.
- Research Institution
  Institute for Molecular and Cellular Biology, Osaka University
Studies on molecular regulation of the immune systemPrincipal Investigator
- Principal Investigator
  
  KISHIMOTO Tadamitsu
- Project Period (FY)
  1989 – 1992
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Research Institution
  Osaka University
生命科学技術の進展への象疫学の対応
- Principal Investigator
  
  奥村康
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  Immunology
- Research Institution
  Juntendo University
米国西海岸地域における分子免疫生物学の進捗に関する調査研究Principal Investigator
- Principal Investigator
  
  岸本忠三
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Overseas Scientific Research
リンフォカインとそのアクセプターに関する免疫学的及び分子生物学的研究Principal Investigator
- Principal Investigator
  
  岸本忠三
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Osaka University
生命科学技術の進展への免疫学の対応
- Principal Investigator
  
  多田富雄
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo
リンフォカインとそのアクセプターに関する免疫学的及び分子生物学的研究Principal Investigator
- Principal Investigator
  
  岸本忠三
- Project Period (FY)
  1985
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Osaka University
Bリンパ球増殖・分化機構の解明とその異常制御に関する研究Principal Investigator
- Principal Investigator
  
  KISHIMOTO Tadamitsu
- Project Period (FY)
  1985 – 1988
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Research Institution
  Institute for Molecular and Cellular Biology, Osaka University
Reaction mechanisms of various growth regulators and differentiation regulators and their clinical applications
- Principal Investigator
  
  SUZUKI Fujio
- Project Period (FY)
  1984 – 1986
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Osaka University

All 2017 2016 2015

All Journal Article Presentation Patent

[Journal Article] TLR4-induced NF-κB and MAPK signaling regulate the IL-6 mRNA stabilizing protein Arid5a.2017
- Author(s)
  Nyati KK, Masuda K, Zaman MM, Dubey PK, Millrine D, Chalise JP, Higa M, Li S, Standley DM, Saito K, Hanieh H, Kishimoto T.
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: 45 Pages: 2687-2703
- DOI
  10.1093/nar/gkx064
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15F15907, KAKENHI-PROJECT-16K19155
[Journal Article] Arid5a-deficient mice are highly resistant to bleomycin-induced lung injury.2017
- Author(s)
  Dubey PK, Masuda K, Nyati KK, Zaman MM, Chalise JP, Millrine D, Kai W, Ripley B, Kishimoto T.
- Journal Title
  
  Int. Immunol.
  
  Volume: 29 Pages: 79-85
- DOI
  10.1093/intimm/dxx004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15F15907
[Journal Article] Arid5a regulates naïve CD4+ T-cell fate through selective stabilization of Stat3 mRNA2016
- Author(s)
  Masuda, K., Ripley, B., Nyati, K., Dubey, P., Zaman, M., Hanieh, H., Hoga, M., Yamashita, K., Standley, D., Mashima, T., Katahira, M., Okamoto, T., Matsuura, Y., Takeuchi, O. and Kishimoto, T.
- Journal Title
  
  the Journal of Experimental Medicine
  
  Volume: 213 Pages: 605619-605619
- DOI
  10.1084/jem.20151289
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H00813, KAKENHI-PROJECT-26840020, KAKENHI-PROJECT-26860328, KAKENHI-PROJECT-15H04736
[Journal Article] Arid5a exacerbates IFN-γ-mediated septic shock by stabilizing T-bet mRNA2016
- Author(s)
  Zaman MM, Masuda K, Nyati KK, Dubey PK, Ripley B, Wang K, Chalise JP, Higa M, Hanieh H, Kishimoto T.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 113 Pages: 11543-11548
- DOI
  10.1073/pnas.1613307113
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15F15907, KAKENHI-PROJECT-16K19155
[Patent] 新規な敗血症治療剤及び/又はそのスクリーニング方法2015
- Inventor(s)
  岸本忠三、増田和哉、中外製薬
- Industrial Property Rights Holder
  岸本忠三、増田和哉、中外製薬
- Industrial Property Rights Type
  特許
- Filing Date
  2015-04-16
- Overseas
- Data Source
  KAKENHI-PROJECT-26860328
[Patent] 新規な肺疾患治療剤及び/又はそのスクリーニング方法2015
- Inventor(s)
  岸本忠三、増田和哉、中外製薬
- Industrial Property Rights Holder
  岸本忠三、増田和哉、中外製薬
- Industrial Property Rights Type
  特許
- Filing Date
  2015-06-30
- Overseas
- Data Source
  KAKENHI-PROJECT-26860328
[Presentation] T-cell intrinsic role of Arid5a as a stability protein of Stat3 mRNA in an IL-6-dependent manner2015
- Author(s)
  Kazuya Masuda, Barry Ripley, Kishan Kumar Nyati, Praveen Kumar Dubey, Mohammad Mahabub-Uz Zaman and Tadamitsu Kishimoto
- Organizer
  The 44th Annual Meeting of The Japanese society for Immunology
- Place of Presentation
  札幌
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-26860328

1. SASAZUKI Takehiko (50014121)

# of Collaborated Projects: 13 results

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2. OKUMURA Ko (50009700)

# of Collaborated Projects: 12 results

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3. HONJO Tasuku (80090504)

# of Collaborated Projects: 9 results

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4. HIRANO Tosio (40136718)

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5. WATANABE Takeshi (40028684)

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6. KIKUTANI Hitoshi (80161412)

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7. TANIGUCHI Masaru (80110310)

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8. TANIGUCHI Tadatsugu (50133616)

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9. TAKATSU Kiyoshi (10107055)

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10. 多田富雄 (10009136)

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11. NISHIKAWA Shinichi (60127115)

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12. AKIRA Shizuo (50192919)

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13. SUGAMURA Kazuo (20117360)

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14. NYATI Kishan Kumar

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26. SAITO Takashi (50205655)

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32. KYO Masaharu (70195395)

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33. WATANABE Masao (90240522)

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35. KOMEDA Yoshifumi (10124215)

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36. KATO Koichi (20211849)

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37. MURAKAMI Yuji (70272995)

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38. YOSHIDA Minoru (80191617)

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39. ISOGAI Akira (20011992)

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40. WAKASUGI Hiro (10112632)

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41. SHINOZAKI Kazuo (20124216)

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42. FUJII Tadashi (20011611)

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43. YAMADA Tetsuji (00191320)

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53. MIYAZONO Kouhei (90209908)

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54. SUZUKI Fujio (40028717)

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88. 村口篤 (20174287)

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89. DAVIS M.

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90. REINHARZ E.

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91. KIYONO H.

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92. LOH D.

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93. KINCADE Paul

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94. BALTIMORE Da

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95. SERCARZ Eli

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96. MCDEVITT Hug

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97. PAUL W. Kincade

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98. DAVID Baltimore

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99. ELI Sercarz

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100. HUGH O. McDevitt

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101. マリセン B.

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102. バーリング R.

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103. マティス D.

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104. ベノワ C.

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105. クーパー J.A.

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106. ハーガン I.M.

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107. ラジャウスキー K.

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108. シラー F.W.

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109. デュマ C.

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110. ツジイ F.I.

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111. ロバーツ G.C.K.

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112. デルセニー M.

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113. フォルセン K.S.

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114. TSUJI Federick

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115. FORSEN Karl

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116. COOPER Jonathan

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117. HAGAN Iain

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118. ROBERTS Gordon

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119. NAKASEKO Nobuyuki

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120. DUMAS C.

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121. SCHELLER Frieder

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122. DELSENY Michel

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123. MATHIS Diane

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124. BENOIST Christophe

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125. MALISSEN Bernard

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126. BALLING Rudolf

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127. RAJEWSKY Klaus

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128. 和田雅人

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129. スレイマン C.W.

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130. ラスキー R.

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131. シュミット R.D.

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132. マリッセン B.

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133. MATHIS D.

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134. BENOIST C

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135. PIATIGORSKY ジェイ

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136. MARTY J.L.

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137. THOMPSON C.

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138. GOSSLER A

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139. VAN Snick J.

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140. MITCHISON N.

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141. BORNKAMM G.W

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142. CHEIN K.R.

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143. HERZENBERG L

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144. YAMANE Isao

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145. NYATI KISHAN

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146. OKAMOTO Toru

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147. 真嶋司

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148. 松浦善治

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KISHIMOTO Tadamitsu 岸本 忠三

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ＭＡＰＫシグナルに関連したＡｒｉｄ５ａタンパク質分解機構の解明Host Researcher

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免疫細胞および自己免疫疾患のＩＬ－６ ｍＲＮＡ調節におけるＡｒｉｄ５ａの役割Host Researcher

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感染症と免疫病の分子生物学と医学Principal Investigator

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Studies on molecular mechanisms of autoimmune diseasesPrincipal Investigator

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免疫病の分子・遺伝子治療に関する研究Principal Investigator

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Studies on the regulation of gene expression in lymphoid cells.Principal Investigator

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Studies on the regulation of gene expression in lymphoid cells.Principal Investigator

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KISHIMOTO Tadamitsu 岸本忠三

免疫細胞および自己免疫疾患のＩＬ－６　ｍＲＮＡ調節におけるＡｒｉｄ５ａの役割Host Researcher

[Journal Article] Arid5a regulates naïve CD4+ T-cell fate through selective stabilization of Stat3 mRNA2016