Kuzuyama Tomohisa 葛山智久

… Alternative Names

Researcher Number	30280952
Other IDs
External Links
Affiliation (Current)	2022: 東京大学, 大学院農学生命科学研究科(農学部), 教授
Affiliation (based on the past Project Information) *help	2022: 東京大学, 農学生命科学研究科, 教授 2018 – 2021: 東京大学, 大学院農学生命科学研究科(農学部), 教授 2014 – 2017: 東京大学, 生物生産工学研究センター, 准教授 2011: The University of Tokyo, 准教授 2011: 東京大学, 生物生産工学センター, 准教授 … More
Review Section/Research Field	Principal Investigator Science and Engineering / Biological Sciences / Bioproduction chemistry/Bioorganic chemistry / Bioproduction chemistry/Bioorganic chemistry / Transformative Research Areas, Section (II) / Bioorganic chemistry / Basic Section 38040:Bioorganic chemistry-related / Medium-sized Section 38:Agricultural chemistry and related fields Except Principal Investigator Science and Engineering / Fisheries chemistry / Bioproduction chemistry/Bioorganic chemistry / Bioorganic chemistry
Keywords	Principal Investigator 生合成 / 放線菌 / 遺伝子 / テルペノイド / biosynthesis / Streptomyces / テルペン / ポリケタイド / 反応機構 / nonmevalonate pathway … More Except Principal Investigator 生合成 / 天然物化学 / BE-40644 / メバロン酸経路 / 非メバロン酸経路 / longestin / carquinostatin / HMG CoA reductase / novobiocin / 2-C-methyl-D-erythritol 2,4-cyclodiphosphate / 3-hydroxy-3-methylglutaryl coenzyme A reductase / 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol / 生合成リデザイン / 合成生物学 / 生合成工学 / 生物分子科学 / 微細藻類 / トリテルペン / 炭化水素 / 代替石油生産 / Botryococcus braunii / イソプレノイド / スクアレン / プレスクアレン二リン酸 / Botryococcene / メチルエリスリトールリン酸 / プレスクアレンニリン酸 / (E)-4-hydroxy-3-methylbut-2-eneyl 1-diphosphate reductase / ゲノム情報 / 物質生産 / バイオインフォマティクス / メタボローム / 二次代謝産物 / 抗生物質 / 抗腫瘍性物質 / ゲノム / 天然物 / ペプチド合成酵素 / 大腸菌 / 化学酵素合成 / 海洋生物 / テルペン生合成 / 抗菌活性 / 遺伝子操作 / 枯草菌 / マラリア / テルペン / 組換え微生物 / 生物活性 / T細胞 / 免疫寛容 / B細胞 / 発生工学 / ポリコ-ム遺伝子 / 水晶体特異的遺伝子発現 / 有機リン系農薬センサー / 転写因子 / T cell / Immunological tolerance / B cell / Transgenics / Polycomb genes / Crystallin gene / Biosensor / Transcriptional factor / naphterpin / BE-40644の生合成 / TANGO-HMBC / テルペノイド化合物の生合成 / Streptomyces aeriouvider / HMG CoAreducatase / Streptomyces aeriouvifer / ナフテルピンの生合成 / メナキノンの生合成 / Streptomyces argenteolus / ロンゲスチンの生合成研究 / non-mevalonate pathway / HMG Co-A reductase / Streptomyces aureouvifer / 3-hydroxy-3-methylglutaryl coezyme A reductase / 2-C-methyl-D-erythritol4-phosphate / 4-(cytidine5'-diphospho)-2-C-methyl-D-erythritol / 2-phospho-4-(cytidine5'-diphospho)-2-C-methyl-D-erythritol / 1-deoxyxylulose5-phosphate reductoisomerase / 2-C-methyl-D-erythriitol 4-phosphate / 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase / 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase / 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol / 1-deoxyxylulose / ノボビオシン / 2-C-methylerythritol / 1-deoxyxylulose 5-phosphate reductoisomerase / 2-C-methyl-D-erythritol 4-phosphate / 2-phospho-4-(cytidine 5' -diphospho)-2-C-methyl-D-erythritol / 1- deoxyxylulose 5-phosphate reductoisomerase / mevalonate pathway / nonmevalonate pathway / メロテルペノイド / 放線菌 Less

Systems biosynthetics based on accumulation, prediction, and creation of biological reactionsArea Organizer
- Area Organizer
  
  葛山智久
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
予知生合成科学・研究総括班Principal Investigator
- Principal Investigator
  
  葛山智久
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  The University of Tokyo
構造多様性一挙構築型生体反応の集積・予知・創出Principal Investigator
- Principal Investigator
  
  葛山智久
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  The University of Tokyo
生物合成系の再設計による革新的核酸系化合物の創製Principal Investigator
- Principal Investigator
  
  葛山智久
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38040:Bioorganic chemistry-related
- Research Institution
  The University of Tokyo
既存モチーフ配列を有さない革新的テルペン合成酵素の探索研究Principal Investigator
- Principal Investigator
  
  葛山智久
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  The University of Tokyo
メロテルペノイド生合成マシナリーの機能と構造に関する研究Host Researcher
- Host Researcher
  
  葛山智久
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Research Field
  
  Bioorganic chemistry
- Research Institution
  The University of Tokyo
Redesigning Biosynthetic Machineries (Project Team)
- Principal Investigator
  
  Abe Ikuro
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
Development and precise functional analysis of innovative biosynthetic machinery to create complex skeletonsPrincipal Investigator
- Principal Investigator
  
  Kuzuyama Tomohisa
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
生合成リデザイン・国際活動支援班
- Principal Investigator
  
  阿部郁朗
- Project Period (FY)
  2016 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
Reaction mechanism of unique terpene synthases, that is elucidated by synthetic chemistry and structural biologyPrincipal Investigator
- Principal Investigator
  
  Kuzuyama Tomohisa
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  The University of Tokyo
Biosynthetic machinery: Deciphering and regulating the system for creating structural diversity of baioactive metabolites
- Principal Investigator
  
  OIKAWA Hideaki
- Project Period (FY)
  2010 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  Hokkaido University
テルペンおよびヌクレオシド系抗生物質生合成マシナリーの解明とエンジニアリングPrincipal Investigator
- Principal Investigator
  
  葛山智久
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
Search for anti-malaria agents from marine organisms
- Principal Investigator
  
  MATSUNAGA Shigeki
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Fisheries chemistry
- Research Institution
  The University of Tokyo
遺伝情報を利用した放線菌二次代謝産物の同定と生合成研究Principal Investigator
- Principal Investigator
  
  葛山智久
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  The University of Tokyo
Studies on the mechanisms for biosynthesis of useful hydrocarbons by a green microalga based on data from EST analyses.
- Principal Investigator
  
  OKADA Shigeru
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Fisheries chemistry
- Research Institution
  The University of Tokyo
非天然型プレニル化芳香族化合物合成系の構築とその利用Principal Investigator
- Principal Investigator
  
  葛山智久
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
イソプレンユニット生合成経路を標的とした抗菌剤と抗マラリア剤開発のための探索研究Principal Investigator
- Principal Investigator
  
  葛山智久
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
Biosynthetic studies on a novel 17-membered macro-cyclic compound produced by a Streptomyces strainPrincipal Investigator
- Principal Investigator
  
  KUZUYAMA Tomohisa
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  The University of Tokyo
非天然型プレニル化芳香族化合物合成系の構築Principal Investigator
- Principal Investigator
  
  葛山智久
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
イソプレンユニット生合成経路を標的とした抗菌剤と抗マラリア剤開発のための探索研究Principal Investigator
- Principal Investigator
  
  葛山智久
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
放線菌の生産する新規17員環マクロサイクリック化合物の生合成研究Principal Investigator
- Principal Investigator
  
  葛山智久
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  The University of Tokyo
新規一次代謝経路、非メバロン酸経路を標的とした抗菌剤開発のための探索研究Principal Investigator
- Principal Investigator
  
  葛山智久
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
未解明一次代謝経路、非メバロン酸経路に関与する遺伝子の機能解析Principal Investigator
- Principal Investigator
  
  葛山智久
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  The University of Tokyo
未解明一次代謝経路、非メバロン酸経路に関与する遺伝子の機能解析Principal Investigator
- Principal Investigator
  
  葛山智久
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
テルペン-ポリケタイド融合化合物ナフテルピンの生合成Principal Investigator
- Principal Investigator
  
  葛山智久
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
未解明一次代謝経路、非メバロン酸経路に関与する遺伝子の機能解析Principal Investigator
- Principal Investigator
  
  葛山智久
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
非メバロン酸経路特異的阻害物質に関する研究Principal Investigator
- Principal Investigator
  
  葛山智久
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  The University of Tokyo
テルペンーポリケタイド融合化合物ナフテルピンの生合成Principal Investigator
- Principal Investigator
  
  葛山智久
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
未解明一次代謝経路、非メバロン酸経路に関する遺伝子の機能解析Principal Investigator
- Principal Investigator
  
  葛山智久
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
新規テルペン生合成経路、非メバロン酸経路の解明、及びその生合成遺伝子の取得Principal Investigator
- Principal Investigator
  
  葛山智久
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  The University of Tokyo
Biosynthetic studies on terpenoids produced by Actinomycetes by focusing on the nonmevalonate pathway
- Principal Investigator
  
  SETO Haruo
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  The University of Tokyo
放線菌の生産するテルペノイドの生合成遺伝子のクローニングと解析Principal Investigator
- Principal Investigator
  
  葛山智久
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  The University of Tokyo
Regulation of Gene Expression
- Principal Investigator
  
  TANIGUCHI Masaru
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Chiba University, School of Medicine
Biosynthetic Studies of terpenoids produced by actinomycetes
- Principal Investigator
  
  SETO Haruo
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  The University of Tokyo

[Book] "Chapter 12 Mevalonate Pathway in Archaea and Bacteria." In Comprehensive Natural Products II. Chemistry & Biology2010
- Author(s)
  Kuzuyama T., H.Hemmi, S.Takahashi(共著)
- Total Pages
  24
- Publisher
  Elsevier
- Data Source
  KAKENHI-ORGANIZER-22108001
[Journal Article] Biosynthetic pathways and enzymes involved in the production of phosphonic acid natural products2021
- Author(s)
  Shiraishi T, Kuzuyama T.
- Journal Title
  
  Biosci Biotechnol Biochem
  
  Volume: 85 Pages: 42-52
- DOI
  10.1093/bbb/zbaa052
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06453
[Journal Article] Reconstitution of a Highly Reducing Type II PKS System Reveals 6π-Electrocyclization Is Required for o-Dialkylbenzene Biosynthesis2021
- Author(s)
  Zhang J, Yuzawa S, Thong WL, Shinada T, Nishiyama M, Kuzuyama T.
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 143 Pages: 2962-2969
- DOI
  10.1021/jacs.0c13378
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06453, KAKENHI-PUBLICLY-19H04661
[Journal Article] Recent Advances in the Biosynthesis of Carbazoles Produced by Actinomycetes2020
- Author(s)
  Kobayashi M, Kuzuyama T.
- Journal Title
  
  Biomolecules
  
  Volume: 10 Pages: 1147-1147
- DOI
  10.3390/biom10081147
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06453
[Journal Article] Structural and mechanistic insight into terpene synthases that catalyze the irregular non-head-to-tail coupling of prenyl substrates2019
- Author(s)
  Kobayashi, M., Kuzuyama, T.
- Journal Title
  
  Chembiochem
  
  Volume: 20 Pages: 29-33
- DOI
  10.1002/cbic.201800510
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06453
[Journal Article] An Unprecedented Cyclization Mechanism in the Biosynthesis of Carbazole Alkaloids in Streptomyces2019
- Author(s)
  Kobayashi M, Tomita T, Shin-ya K, Nishiyama M, Kuzuyama T.
- Journal Title
  
  Angew Chem Int Ed Engl
  
  Volume: 58 Pages: 13349-13353
- DOI
  10.1002/anie.201906864
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06453
[Journal Article] Recent advances in the biosynthesis of nucleoside antibiotics2019
- Author(s)
  Shiraishi T, Kuzuyama T.
- Journal Title
  
  J Antibiot
  
  Volume: 72 Pages: 913-923
- DOI
  10.1038/s41429-019-0236-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06453
[Journal Article] 新奇骨格を創成する革新的生合成マシナリーの開拓2019
- Author(s)
  白石太郎、葛山智久
- Journal Title
  
  FARUAW
  
  Volume: 55 Issue: 7 Pages: 679-683
- DOI
  10.14894/faruawpsj.55.7_679
- NAID
  130007671598
- ISSN
  0014-8601, 2189-7026
- Language
  Japanese
- Data Source
  KAKENHI-PLANNED-16H06453
[Journal Article] An Unusual Skeletal Rearrangement in the Biosynthesis of the Sesquiterpene Trichobrasilenol from Trichoderma2019
- Author(s)
  Murai K, Lauterbach L, Teramoto K, Quan Z, Barra L, Yamamoto T, Nonaka K, Shiomi K, Nishiyama M, Kuzuyama T, Dickschat JS.
- Journal Title
  
  Angew Chem Int Ed Engl
  
  Volume: 58 Pages: 15046-15050
- DOI
  10.1002/anie.201907964
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06453
[Journal Article] The Amipurimycin and Miharamycin Biosynthetic Gene Clusters: Unraveling the Origins of 2-Aminopurinyl Peptidyl Nucleoside Antibiotics2019
- Author(s)
  Romo AJ, Shiraishi T, Ikeuchi H, Lin GM, Geng Y, Lee YH, Liem PH, Ma T, Ogasawara Y, Shin-ya K, Nishiyama M, Kuzuyama T, Liu HW.
- Journal Title
  
  J Am Chem Soc
  
  Volume: 141 Pages: 14152-14159
- DOI
  10.1021/jacs.9b03021
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06453
[Journal Article] Biosynthesis of the uridine-derived nucleoside antibiotic A-94964: Identification and characterization of the biosynthetic gene cluster provide insight into the biosynthetic pathway2019
- Author(s)
  Shiraishi, T., Nishiyama, M., Kuzuyama T.
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 17 Pages: 461-466
- DOI
  10.1039/c8ob02765j
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06453
[Journal Article] Biochemical and Structural Analysis of FomD That Catalyzes the Hydrolysis of Cytidylyl (S)-2-Hydroxypropylphosphonate in Fosfomycin Biosynthesis2018
- Author(s)
  Sato, S., Miyanaga, A., Kim, S. Y., Kuzuyama, T., Kudo, F., Eguchi, T.
- Journal Title
  
  Biochemistry
  
  Volume: 57 Pages: 4858-4866
- DOI
  10.1021/acs.biochem.8b00690
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06453, KAKENHI-PUBLICLY-17H05434, KAKENHI-PROJECT-18H02095
[Journal Article] Discovery of an antibacterial isoindolinone-containing tetracyclic polyketide by cryptic gene activation and characterization of its biosynthetic gene cluster2018
- Author(s)
  Thong, W. L., Shin-ya, K., Nishiyama, M., Kuzuyama, T.
- Journal Title
  
  ACS Chem. Biol.
  
  Volume: 13 Pages: 2615-2622
- DOI
  10.1021/acschembio.8b00553
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06453
[Journal Article] C-Methylation catalyzed by Fom3, a cobalamin-dependent radical S-adenosyl-L-methionine enzyme in fosfomycin biosynthesis2018
- Author(s)
  Sato, S., Kudo, F., Kuzuyama, T., Hammerschmidt, F., Eguchi, T.
- Journal Title
  
  Biochemistry
  
  Volume: 57 Pages: 4963-4966
- DOI
  10.1021/acs.biochem.8b00614
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06453, KAKENHI-PUBLICLY-17H05434, KAKENHI-PROJECT-18H02095
[Journal Article] Discovery of unprecedented hydrazine-forming machinery in bacteria2018
- Author(s)
  Matsuda Kenichi、Tomita Takeo、Shin-ya Kazuo、Wakimoto Toshiyuki、Kuzuyama Tomohisa、Nishiyama Makoto
- Journal Title
  
  J. Am. Chem. Soc.
  
  Volume: 140 Pages: 9083-9086
- DOI
  10.1021/jacs.8b05354
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06448, KAKENHI-PLANNED-16H06453, KAKENHI-PROJECT-17H06168, KAKENHI-PROJECT-18H02581, KAKENHI-PROJECT-17F17114
[Journal Article] Characterization of bafilomycin biosynthesis in Kitasatospora setae KM-6054 and comparative analysis of gene clusters in Actinomycetales microorganisms.2017
- Author(s)
  Nara, A., Hashimoto, T., Komatsu, M., Nishiyama, M., Kuzuyama, T., Ikeda, H.
- Journal Title
  
  J. Antibiot.
  
  Volume: 印刷中 Pages: 616-624
- DOI
  10.1038/ja.2017.33
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06453, KAKENHI-PLANNED-16H06447
[Journal Article] Biosynthetic Origin of the Hydroxamic Acid Moiety of Trichostatin A: Identification of Unprecedented Enzymatic Machinery Involved in Hydroxylamine Transfer2017
- Author(s)
  Kei Kudo, Taro Ozaki, Kazuo Shin-ya, Makoto Nishiyama, Tomohisa Kuzuyama
- Journal Title
  
  J. Am. Chem. Soc.
  
  Volume: 139 Pages: 6799-6802
- DOI
  10.1021/jacs.7b02071
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06453
[Journal Article] Structural Insights into the CotB2-Catalyzed Cyclization of Geranylgeranyl Diphosphate to the Diterpene Cyclooctat-9-en-7-ol2017
- Author(s)
  Takeo Tomita, Seung-Young Kim, Kazuya Teramoto, Ayuko Meguro, Taro Ozaki, Ayako Yoshida, Yudai Motoyoshi, Naoki Mori, Ken Ishigami, Hidenori Watanabe, Makoto Nishiyama, Tomohisa Kuzuyama
- Journal Title
  
  ACS Chemical Biology
  
  Volume: 12 Pages: 1621-1628
- DOI
  10.1021/acschembio.7b00154
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06453, KAKENHI-PROJECT-17J40083
[Journal Article] Structure and Mechanism of the Monoterpene Cyclolavandulyl Diphosphate Synthase that Catalyzes Consecutive Condensation and Cyclization2017
- Author(s)
  Takeo Tomita, Masaya Kobayashi, Yuma Karita, Yoko Yasuno, Tetsuro Shinada, Makoto Nishiyama, Tomohisa Kuzuyama
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 56 Pages: 14913-14917
- DOI
  10.1002/anie.201708474
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06453, KAKENHI-PUBLICLY-17H05448, KAKENHI-PROJECT-15J10131
[Journal Article] Methylcobalamin-dependent radical SAM C-methyltransferase Fom3 recognizes cytidylyl-2-hydroxyethylphosphonate and catalyzes the nonstereoselective C-methylation in fosfomycin biosynthesis2017
- Author(s)
  Sato Shusuke、Kudo Fumitaka、Kim Seung-Young、Kuzuyama Tomohisa、Eguchi Tadashi
- Journal Title
  
  Biochemistry
  
  Volume: 56 Pages: 3519-3522
- DOI
  10.1021/acs.biochem.7b00472
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06451, KAKENHI-PLANNED-16H06453, KAKENHI-PUBLICLY-17H05434, KAKENHI-PROJECT-15H03834
[Journal Article] Mechanistic insights into Diels-Alder reactions in natural product biosynthesis2017
- Author(s)
  Hashimoto, T., Kuzuyama, T.
- Journal Title
  
  Curr. Opin. Chem. Biol.
  
  Volume: 35 Pages: 117-123
- DOI
  10.1016/j.cbpa.2016.09.015
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06453
[Journal Article] Fosfomycin Biosynthesis via Transient Cytidylylation of 2-Hydroxyethylphosphonate by the Bifunctional Fom1 Enzyme2017
- Author(s)
  Su-Hee Cho, Seung-Young Kim, Takeo Tomita, Taro Shiraishi, Jin-Soo Park, Shusuke Sato, Fumitaka Kudo, Tadashi Eguchi, Nobutaka Funa, Makoto Nishiyama and Tomohisa Kuzuyama
- Journal Title
  
  ACS Chem. Biol.
  
  Volume: 12 Pages: 2209-2215
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06453
[Journal Article] Biosynthetic studies on terpenoids produced by Streptomyces2017
- Author(s)
  Kuzuyama, T.
- Journal Title
  
  J. Antibiot.
  
  Volume: 印刷中 Pages: 811-818
- DOI
  10.1038/ja.2017.12
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-16H06453, KAKENHI-PROJECT-26292058
[Journal Article] An unusual terpene cyclization mechanism involving a carbon-carbon bond rearrangement2015
- Author(s)
  Meguro, A., Motoyoshi, Y., Teramoto, K., Ueda, S., Totsuka, Y., Tomita, T., Kim, S.-Y., Kimura, T. Igarashi, M., Sawa, R., Shinada, T., Nishiyama, M. and Kuzuyama, T.
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 127 Pages: 4353-4356
- DOI
  10.1002/anie.201411923
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23228001, KAKENHI-PROJECT-26292058
[Journal Article] "Cation-Stitching Cascade": exquisite control of terpene cyclization in cyclooctatin biosynthesis2015
- Author(s)
  Sato, H., Teramoto, K., Masumoto, Y., Tezuka, N., Sakai, K., Ueda, S., Totsuka, Y., Shinada, T., Nishiyama, M., Wang, C., Kuzuyama, T., Uchiyama, M.
- Journal Title
  
  Sci. Rep.
  
  Volume: 5 Pages: 18471-18471
- DOI
  10.1038/srep18471
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23228001, KAKENHI-PROJECT-14F04908, KAKENHI-PROJECT-26292058, KAKENHI-PROJECT-24229001
[Journal Article] Terpene synthases are widely distributed in bacteria.2015
- Author(s)
  Y. Yamada, T. Kuzuyama, M. Komatsu, K. Shin-ya, S. Omura, D.E. Cane, H. Ikeda
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: 112 Pages: 857-857
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-ORGANIZER-22108001
[Journal Article] Genome Mining for Sesterterpenes Using Bifunctional Terpene Synthases Reveals a Unified Intermediate of Di/Sesterterpenes2015
- Author(s)
  Y. Ye, A. Minami, A. Mandi, C. Liu, T. Taniguchi, T. Kuzuyama, K. Monde, K. Gomi, and H. Oikawa
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 137 Pages: 11846-11853
- DOI
  10.1021/jacs.5b08319
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H01835, KAKENHI-PROJECT-15H03111, KAKENHI-PROJECT-26292058
[Journal Article] Terpene synthases are widely distributed in bacteria.2015
- Author(s)
  Y. Yamada, T. Kuzuyama, M. Komatsu, K. Shin-ya, S. Omura, D.E. Cane, H. Ikeda
- Journal Title
  
  Proceedings of the National Academy of Sciences of the United States of America
  
  Volume: 112 Pages: 857-862
- DOI
  10.1073/pnas.1422108112
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-22108006, KAKENHI-PROJECT-25450112, KAKENHI-PROJECT-26292058
[Journal Article] Crystallization and preliminary X-ray diffraction analysis of cyclolavandulyl diphosphate synthase, a new member of the cis-isoprenyl diphosphate synthase superfamily2014
- Author(s)
  Tomita T, Ozaki T, Matsuda K, Nishiyama M, Kuzuyama T.
- Journal Title
  
  Acta Crystallographica Section F Structural Biology Communications
  
  Volume: 70 Pages: 1410-1413
- DOI
  10.1107/s2053230x14018883
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26292058
[Journal Article] Cyclolavandulyl skeleton biosynthesis via both condensation and cyclization catalyzed by an unprecedented member of the cis-isoprenyl diphosphate synthase superfamily2014
- Author(s)
  Ozaki T, Zhao P, Shinada T, Nishiyama M, Kuzuyama T.
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 136 Pages: 4837-4840
- DOI
  10.1021/ja500270m
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26292058
[Journal Article] 構造多様性を創出する新奇テルペノイド合成酵素の発見2014
- Author(s)
  尾崎太郎、葛山智久
- Journal Title
  
  バイオサイエンスとインダストリー
  
  Volume: 72 Pages: 412-414
- NAID
  40020209341
- Data Source
  KAKENHI-PROJECT-26292058
[Journal Article] The single cellular green microalga Botryococcus braunii, race B possesses three distinct 1-deoxy-D-xylulose 5-phosphate synthases2012
- Author(s)
  D. Matsushima、H. Jenke-Kodama、Y. Sato、Y. Fukunaga、K. Sumimoto、T. Kuzuyama、S. Matsunaga、S. Okada
- Journal Title
  
  Plant Sci.
  
  Volume: 185-186 Pages: 309-320
- DOI
  10.1016/j.plantsci.2012.01.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380130
[Journal Article] テルペノイドの増産を可能にする新規アセトアセチルCoA合成酵素2011
- Author(s)
  岡村英治、葛山智久
- Journal Title
  
  バイオサイエンスとインダストリー
  
  Volume: 69 Pages: 125-126
- NAID
  10027781267
- Data Source
  KAKENHI-PROJECT-21380071
[Journal Article] Unprecedented acetoacetyl-coenzyme A synthesizing enzyme of the thiolase superfamily involved in the mevalonate pathway2010
- Author(s)
  Eiji Okamura, Takeo Tomita, Ryuichi Sawa, Makoto Nishiyama, Tomohisa Kuzuyama
- Journal Title
  
  Proc.Natl.Acad.Sci.USA
  
  Volume: 107 Pages: 11265-11270
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380071
[Journal Article] Unprecedented acetoacetyl-coenzyme A synthesizing enzyme of the thiolase superfamily involved in the mevalonate pathway2010
- Author(s)
  Okamura E, Tomita T, Sawa R, Nishiyama M, Kuzuyama T
- Journal Title
  
  Proc.Natl.Acad.Sci.USA
  
  Volume: 107 Pages: 11265-11270
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22108001
[Journal Article] Cloning and heterologous expression of the cyclooctatin biosynthetic gene cluster afford aditerpene cyclase and two P450 hydroxylases2009
- Author(s)
  Kim S-Y., P.Zhao, M.Igarashi, R.Sawa, M.Nishiyama, T.Kuzuyama
- Journal Title
  
  Chemistry & Biology 16
  
  Pages: 736-743
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380071
[Journal Article] テルペノイドーポリケチド融合化合物の生合成とその鍵酵素を利用した有用物質生産2007
- Author(s)
  T. Kuzuyama
- Journal Title
  
  蛋白質・核酸・酵素 52
  
  Pages: 1736-1741
- Data Source
  KAKENHI-PROJECT-18018008
[Journal Article] Preferential recognition of a microbial metabolite by human Vγ2Vδ2 T cells.2007
- Author(s)
  Puan, K.J., C. Jin, H. Wang, G. Sarikonda, A.M. Raker, H.K. Lee, M.I. Samuelson, E. Marker-Hermann, L. Pasa-Tolic, E. Nieves, J.L. Giner, T. Kuzuyama, and C.T. Morita.
- Journal Title
  
  Int. Immunol. 19
  
  Pages: 657-673
- NAID
  10027388917
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18032022
[Journal Article] 天然有機化合物の多様性を生み出す芳香族基質プレニル基転移酵素2006
- Author(s)
  葛山智久, 熊野匠人, 西山真
- Journal Title
  
  ファインケミカル 35・2
  
  Pages: 5-14
- Data Source
  KAKENHI-PROJECT-17019011
[Journal Article] 天然有機化合物の多様性を生み出す芳香族基質プレニル基転移酵素2006
- Author(s)
  葛山智久, 熊野匠人
- Journal Title
  
  ファインケミカル 35・2
  
  Pages: 5-14
- Data Source
  KAKENHI-PROJECT-18018008
[Journal Article] Structural basis for the promiscuous biosynthetic prenylation of aromatic natural products2005
- Author(s)
  Tomohisa Kuzuyama, Joseph P.Noel, Stephane B.Richard
- Journal Title
  
  Nature 435
  
  Pages: 983-987
- Data Source
  KAKENHI-PROJECT-17019011
[Patent] Novel Aromatic Prenyltransferases, Nucleic Acids Encoding Same and Uses2006
- Inventor(s)
  Tomohisa Kuzuyama, Joseph P.Noel, Stephane B.Richard
- Industrial Property Rights Holder
  Toudai TLO, The Salk Institute for Biological Studies
- Filing Date
  2006-01-27
- Data Source
  KAKENHI-PROJECT-17019011
[Patent] GPP synthase derived from Actinomycetes and method for producing GPP using it2005
- Inventor(s)
  Tomohisa Kuzuyama, Joseph P.Noel, Stephane B.Richard
- Industrial Property Rights Holder
  Toudai TLO, The Salk Institute for Biological Studies
- Filing Date
  2005-09-07
- Data Source
  KAKENHI-PROJECT-17019011
[Presentation] 複雑骨格を構築する生合成マシナリーの機能予知2021
- Author(s)
  葛山智久
- Organizer
  日本農芸化学会2021年度大会
- Invited
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] 生合成の in vitro 再構成系を利用した新規 trichostatin 類縁体の創生2021
- Author(s)
  松田悠太郎、湯澤賢、青山美和子、大澤宏祐、吉田将人、土井隆行、新家一男、西山真、葛山智久
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] スクアレン合成酵素に似た放線菌由来芳香族プレニル基転移酵素の構造学的研究2021
- Author(s)
  永田隆平、末宗周憲、山本将輝、小林正弥、品田哲郎、西山真、永野真吾、葛山智久
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] Biosynthesis of the nucleoside-derived natural product angustmycin2021
- Author(s)
  Jiaqi XIA, Taro SHIRAISHI, Tomohisa KUZUYAMA
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] イソプレノイド生合成経路は新発見の宝庫2019
- Author(s)
  葛山　智久
- Organizer
  日本農芸化学会2019年度大会シンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] Understanding Biochemical Mechanism in Natural Product Biosynthesis2019
- Author(s)
  Tomohisa Kuzuyama
- Organizer
  Genentech Lecture
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] Understanding Biochemical Mechanism in Terpenoid Biosynthesis2019
- Author(s)
  Tomohisa Kuzuyama
- Organizer
  日中分野別ハイレベル研究者交流会2019：医薬・健康領域
- Invited
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] 生合成再設計を指向した天然化合物骨格形成機構の解明2019
- Author(s)
  葛山智久
- Organizer
  微生物ウィークシンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] 微生物の多様なイソプレノイド生合成機構2019
- Author(s)
  葛山智久
- Organizer
  琉球大学熱帯生物圏研究センター第5回 TBRCセミナー
- Invited
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] 複雑骨格を創成する革新的生合成マシナリーの開拓と精密機能解析2019
- Author(s)
  葛山智久
- Organizer
  新学術領域生合成リデザイン第７回公開シンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] Unraveling the biosynthesis of the phosphonate antibiotic fosfomycin2018
- Author(s)
  葛山　智久
- Organizer
  1st German-Japanese Joint Symposium on the Biosynthesis of Natural Products
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] Trichoderma属糸状菌由来Brasilane型セスキテルペン合成酵素の機能解析2018
- Author(s)
  寺本　和矢、野中　健一、塩見　和朗、西山　真、葛山　智久
- Organizer
  日本農芸化学会2018年度大会
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] 放線菌のメロテルペノイド生合成における普遍的脱アミノ化反応に関する研究2018
- Author(s)
  葛山　智久
- Organizer
  日本応用酵素協会第44回研究発表会
- Invited
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] Activation of cryptic gene clusters led to the discovery of novel polyketides in Streptomyces2018
- Author(s)
  葛山　智久
- Organizer
  The 3rd A3 Foresight Symposium on Chemical & Synthetic Biology of Natural Products
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] プレニルインドール化合物carquinostatin Aの生合成研究2018
- Author(s)
  小林　正弥、新家　一男、西山　真、葛山　智久
- Organizer
  日本農芸化学会2018年度大会
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] 新規thioviridamide類縁体の創出と生合成酵素の機能解析2018
- Author(s)
  工藤　慧、小岩井　花恵、新家　一男、池田　治生、西山　真、葛山　智久
- Organizer
  日本農芸化学会2018年度大会
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] Understanding biochemical mechanism in natural product biosynthesis2018
- Author(s)
  葛山　智久
- Organizer
  Egypt/Japan Joint Seminar on Natural Products
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] ペプチジルヌクレオシド系抗生物質Amipurimycinの生合成に関する研究2018
- Author(s)
  池内　秀雄、白石　太郎、新家　一男、西山　真、葛山　智久
- Organizer
  日本農芸化学会2018年度大会
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] 複雑骨格を創成する革新的生合成マシナリーの開拓と精密機能解析2018
- Author(s)
  葛山　智久
- Organizer
  新学術領域生合成リデザイン第5回公開シンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] 放線菌のメロテルペノイド生合成における普遍的脱アミノ化機構の解析2018
- Author(s)
  野口　智弘、工藤　慧、西山　真、葛山　智久
- Organizer
  日本農芸化学会2018年度大会
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] 原核生物由来テルペン合成酵素の探索と解析2018
- Author(s)
  村井恵一、新家　一男、西山　真、葛山　智久
- Organizer
  日本農芸化学会2018年度大会
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] Activation of cryptic gene clusters led to the discovery of novel polyketides in Streptomyces2017
- Author(s)
  Thong, Wei-li, Kuzuyama, T.
- Organizer
  JSPS-NRCT2017
- Place of Presentation
  バンコク（タイ）
- Year and Date
  2017-03-01
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] 原核生物由来テルペン合成酵素の探索と解析2017
- Author(s)
  村井　恵一、新家　一男、西山　真、葛山　智久
- Organizer
  第27回イソプレノイド研究会
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] Investigating Biosynthetic of the Antituberculous Agent Caprazamycin2017
- Author(s)
  Taro Shiraishi, Makoto Nishiyama, Tomohisa Kuzuyama
- Organizer
  International Symposium on Biology of Actinomycetes
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] シクロラバンデュリル二リン酸合成酵素の結晶構造解析2017
- Author(s)
  小林正弥, 富田武郎, 品田哲郎, 西山真, 葛山智久
- Organizer
  日本農芸化学会2017年度大会
- Place of Presentation
  京都女子大学（京都府京都市）
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] Elucidation of Multistep Reaction Cascade Catalyzed by the Diterpene Cyclase CotB22017
- Author(s)
  Kazuya Teramoto, Makoto Nishiyama, Tomohisa Kuzuyama
- Organizer
  International Symposium on Biology of Actinomycetes
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] Discovery and biosynthetic characterization of a natural product biosynthesized via AmCP-mediated machinery2017
- Author(s)
  Matsuda, K., Hasebe, F., Shiwa, Y., Kanesaki, Y., Tomita, T., Yoshikawa, H., Shin-ya, K., Kuzuyama, T. Nishiyama, M.
- Organizer
  US-Japan Seminar on the Biosynthesis of Natural Products for Young Researchers
- Place of Presentation
  東京工業大学（東京都目黒区）
- Year and Date
  2017-03-04
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] Novel Polyketides Discovered via Activation of Cryptic Genes from Streptomyces2017
- Author(s)
  Wei li Thong, Kazuo Shin-ya, Makoto Nishiyama, Tomohisa Kuzuyama
- Organizer
  International Symposium on Biology of Actinomycetes
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] 放線菌のメロテルペノイド生合成における普遍的脱アミノ化機構の解析2017
- Author(s)
  野口智弘、工藤慧、西山真、葛山智久
- Organizer
  日本農芸化学会2017年度大会
- Place of Presentation
  京都女子大学（京都府東山区）
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] カプラザマイシン生合成に関与する特異なメチル基転移酵素の機能解析2017
- Author(s)
  白石　太郎、五十嵐　雅之、西山真、葛山　智久
- Organizer
  日本放線菌学会2017年度大会
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] Understanding Biochemical Mechanism in Natural Product Biosynthesis2017
- Author(s)
  Tomohisa Kuzuyama
- Organizer
  1st China-Japan Joint Symposium on Natural Product Biosynthesis
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] Biosynthesis of a Histone Deacetylase Inhibitor Trichostatin A2017
- Author(s)
  Kudo K, Shin-ya, K, Nishiyama, M., Kuzuyama, K.
- Organizer
  Biosynthesis of a Histone Deacetylase Inhibitor Trichostatin A
- Place of Presentation
  東京工業大学（東京都目黒区）
- Year and Date
  2017-03-04
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] Structural Studies on the Biosynthesis of Cyclolavandulyl Skeleton Catalyzed by an Unprecedented Terpene Synthase2017
- Author(s)
  Masaya Kobayashi, Takeo Tomita, Makoto Nishiyama, Tomohisa Kuzuyama
- Organizer
  International Symposium on Biology of Actinomycetes
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] Biosynthesis of Prenylated Indole Alkaloids in Streptomyces2017
- Author(s)
  Masaya Kobayashi, Makoto Nishiyama, Tomohisa Kuzuyama
- Organizer
  US-Japan Seminar on the Biosynthesis of Natural Products for Young Researchers
- Place of Presentation
  東京工業大学（東京都目黒区）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] Biosynthesis of the Nucleoside Antibiotic A-949642017
- Author(s)
  Shiraishi, T., Nishiyama, M., Kuzuyama, T.
- Organizer
  US-Japan Seminar on the Biosynthesis of Natural Products for Young Researchers
- Place of Presentation
  東京工業大学（東京都目黒区）
- Year and Date
  2017-03-04
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] 放線菌のメロテルペノイド生合成における普遍的脱アミノ化機構の解析2017
- Author(s)
  野口智弘, 工藤慧, 西山真, 葛山智久
- Organizer
  日本放線菌学会2017年度大会
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] カプラザマイシン生合成における小タンパク質を介したアシル化反応の発見2017
- Author(s)
  白石太郎、廣昇、五十嵐雅之、西山真、葛山智久
- Organizer
  日本農芸化学会2017年度大会
- Place of Presentation
  京都女子大学（京都府東山区）
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] Understanding biochemical mechanism in natural product biosynthesis2017
- Author(s)
  Tomohisa Kuzuyama
- Organizer
  Directing Biosynthesis V
- Place of Presentation
  コベントリー（英国）
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] Novel Polyketides Discovered via Activation of Cryptic Genes from Streptomyces2017
- Author(s)
  Thong, Wei-li, Kuzuyama, T.
- Organizer
  US-Japan Seminar on the Biosynthesis of Natural Products for Young Researchers
- Place of Presentation
  東京工業大学（東京都目黒区）
- Year and Date
  2017-03-04
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] 複雑骨格を創成する革新的生合成マシナリーの開拓と精密機能解析2017
- Author(s)
  葛山智久
- Organizer
  新学術領域「生合成リデザイン」第一回公開シンポジウム
- Place of Presentation
  東京大学（東京都文京区）
- Invited
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] プレニルインドール化合物carquinostatin Aの生合成研究2017
- Author(s)
  小林　正弥,　新家　一男,　西山　真,　葛山　智久
- Organizer
  日本放線菌学会2017年度大会
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] Trichoderma属糸状菌由来テルペン合成酵素の探索と機能解析2017
- Author(s)
  寺本和矢、石神健、野中健一、塩見和朗、西山真、葛山智久
- Organizer
  日本農芸化学会2017年度大会
- Place of Presentation
  京都女子大学（京都府京都市）
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] Biosynthetic Origin of the Hydroxamic Acid Moiety of Trichostatin A: Identification of Unprecedented Enzymatic Machinery Involved in Hydroxylamine Transfer2017
- Author(s)
  Kei Kudo, Taro Ozaki, Kazuo Shin-ya, Makoto Nishiyama, Tomohisa Kuzuyama
- Organizer
  International Symposium on Biology of Actinomycetes
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] Mechanistic insights into terpene cyclization reactions2017
- Author(s)
  Tomohisa Kuzuyama
- Organizer
  U.S./Japan Seminar on Natural Product Biosynthesis
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] Isolation of isoindolinomycin, a novel isoindolinone-derived natural product discovered via activation of cryptic gene cluster from Streptomyces2017
- Author(s)
  Thong, Wei-li, Kuzuyama, T.
- Organizer
  日本農芸化学会2017年度大会
- Place of Presentation
  京都女子大学（京都府東山区）
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] ペプチジルヌクレオシド系抗生物質Amipurimycinの生合成に関する研究2017
- Author(s)
  池内秀雄,　新家一男　西山真,　葛山智久
- Organizer
  日本農芸化学会2017年度大会
- Place of Presentation
  京都女子大学（京都府東山区）
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] シクロラバンデュリル2リン酸合成酵素の結晶構造解析2016
- Author(s)
  小林正弥、富田武郎、品田哲郎、西山真、葛山智久
- Organizer
  イソプレノイド研究会
- Place of Presentation
  長崎シーボルト大学（長崎県西彼杵郡）
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] 放線菌のテルペノイド生合成機構に関する研究2016
- Author(s)
  葛山智久
- Organizer
  北里大学受賞講演会
- Place of Presentation
  北里大学（東京都港区）
- Year and Date
  2016-01-29
- Invited
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] テルペンに関する最近の話題2016
- Author(s)
  葛山智久
- Organizer
  日本農芸化学会2016年度大会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2016-03-27
- Invited
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] Bacillus alcalophilus由来セスタテルペン/トリテルペン合成酵素ホモログの機能解析2016
- Author(s)
  田中慧里奈、石神健、富田武郎、西山真、葛山智久
- Organizer
  イソプレノイド研究会
- Place of Presentation
  長崎シーボルト大学（長崎県西彼杵郡）
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] 放線菌由来ジテルペン環化酵素CotB2が触媒する精巧な環化反応機構の解明2016
- Author(s)
  寺本和矢、目黒亜由子、本吉祐大、佐藤玄、増本優衣、手塚則亨、坂井健太、上田翔太、遠塚悠輔、安藤祐美、富田武郎、金承榮、木村智之、五十嵐雅之、澤竜一、品田哲郎、王超、内山真伸、西山真、葛山智久
- Organizer
  日本農芸化学会2016年度大会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] 微生物由来テルペノイドの生合成研究2016
- Author(s)
  葛山智久
- Organizer
  住木・梅澤記念賞受賞講演会
- Place of Presentation
  学士会館（東京都千代田区）
- Invited
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] アシル化反応に関与する新奇キャリアタンパク質の発見2016
- Author(s)
  白石太郎、廣昇、五十嵐雅之、西山真、葛山智久
- Organizer
  日本放線菌学会2016年度大会
- Place of Presentation
  東京大学（東京都文京区）
- Year and Date
  2016-09-08
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] ジテルペン環化酵素が触媒する多段階反応機構の解明2016
- Author(s)
  寺本和矢、目黒亜由子、本吉祐大、佐藤玄、増本優衣、手塚則亨、坂井健太、上田翔太、遠塚悠輔、安藤祐美、富田武郎、金承榮、木村智之、五十嵐雅之、澤竜一、品田哲郎、王超、内山真伸、西山真、葛山智久
- Organizer
  天然有機化合物討論会
- Place of Presentation
  東北大学（宮城県仙台市）
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] 放線菌由来新奇テルペン環化酵素の結晶構造解析2016
- Author(s)
  小林正弥、尾﨑太郎、富田武郎、西山真、葛山智久
- Organizer
  日本放線菌学会2016年度大会
- Place of Presentation
  東京大学（東京都文京区）
- Year and Date
  2016-09-01
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] Structural and biochemical studies of cytidylyltransferase involved in the biosynthesis of the phosphonate-antibiotic fosfomycin2016
- Author(s)
  Cho, Su-Hee, Kuzuyama, T.
- Organizer
  日本放線菌学会2016年度大会
- Place of Presentation
  東京大学（東京都文京区）
- Year and Date
  2016-09-08
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] Biosynthesis of novel polyketides discovered via activation of cryptic genes from Streptomyces2016
- Author(s)
  Thong, Wei-li, Kuzuyama, T.
- Organizer
  日本放線菌学会2016年度大会
- Place of Presentation
  東京大学（東京都文京区）
- Year and Date
  2016-09-08
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] Biosynthesis of the antituberculous agent caprazamycin2016
- Author(s)
  Taro Shiraishi, Makoto Nishiyama and Tomohisa Kuzuyama
- Organizer
  2016 SIMB Annual Meeting and Exhibition
- Place of Presentation
  ニューオーリンズ（米国）
- Year and Date
  2016-07-24
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] 放線菌由来環状天然化合物の骨格形成機構2016
- Author(s)
  葛山智久
- Organizer
  日本農芸化学会2016年度第一回関東支部例会
- Place of Presentation
  東京農業大学（東京都世田谷区）
- Invited
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] 放線菌の生産するヌクレオシド系抗結核性抗生物質に関する研究2016
- Author(s)
  葛山智久
- Organizer
  HiHA 第８回 Workshop「代謝と健康」
- Place of Presentation
  広島大学（広島県東広島市）
- Invited
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] 微生物由来テルペノイドの生合成研究2016
- Author(s)
  葛山智久
- Organizer
  住木・梅澤記念賞受賞講演
- Place of Presentation
  学士会館（東京都千代田区）
- Invited
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] Studies on the Biosynthesis of the Peptidyl Nucleoside Antibiotic Amipurimycin2016
- Author(s)
  池内秀雄、新家一男、西山真、葛山智久
- Organizer
  日本放線菌学会2016年度大会
- Place of Presentation
  東京大学（東京都文京区）
- Year and Date
  2016-09-08
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] Trichoderma属糸状菌由来モノテルペン合成酵素の探索と機能解析2016
- Author(s)
  寺本和矢、石神健、野中健一、塩見和朗、西山真、葛山智久
- Organizer
  イソプレノイド研究会
- Place of Presentation
  長崎シーボルト大学（長崎県西彼杵郡）
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] アリル基質同士の縮合と環化反応を触媒する新奇テルペン合成酵素の発見 ○小林正弥, 尾﨑太郎1, 趙平1,富田武郎, 苅田祐馬, 保野陽子, 西村栄治, 品田哲郎, 西山真, 葛山智久2015
- Author(s)
  小林正弥, 尾﨑太郎, 趙平, 富田武郎, 苅田祐馬, 保野陽子, 西村栄治, 品田哲郎, 西山真, 葛山智久
- Organizer
  イソプレノイド研究会
- Place of Presentation
  東北大学（宮城県仙台市）
- Year and Date
  2015-09-14
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] 放線菌由来ジテルペン環化酵素CotB2の特異な環化反応機構の解明2015
- Author(s)
  寺本和矢, 目黒亜由子, 本吉祐大, 上田翔太, 遠塚悠輔, 安藤祐美, 坂井健太,富田武郎, 金承榮, 木村智之, 五十嵐雅之, 澤竜一, 品田哲郎, 西山真, 葛山智久
- Organizer
  イソプレノイド研究会
- Place of Presentation
  東北大学（宮城県仙台市）
- Year and Date
  2015-09-14
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] 放線菌のテルペノイド生合成機構に関する研究2015
- Author(s)
  葛山智久
- Organizer
  日本放線菌学会
- Place of Presentation
  富山国際会議場（富山県富山市）
- Year and Date
  2015-09-07
- Invited
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] Biosynthesis of terpenoids produced by Streptomyces2015
- Author(s)
  Tomohisa Kuzuyama
- Organizer
  2015 KMB International Symposium & Annual Meeting
- Place of Presentation
  全州（韓国）
- Year and Date
  2015-06-24
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] ゲラニルファルネソールおよびファルネシルファルネソールの合成研究2015
- Author(s)
  石神健、葛山智久、渡邉秀典
- Organizer
  香料・テルペンおよび精油化学に関する討論会
- Place of Presentation
  近畿大学（大阪府東大阪市）
- Year and Date
  2015-09-05
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] Bacterial Indole Prenyltransferases for Chemoenzymatic Synthesis of Prenylated Compounds2015
- Author(s)
  Intan Timur Maisyarah, Kazuo shin-ya, Makoto Nishiyama, Tomohisa Kuzuyama
- Organizer
  日本放線菌学会
- Place of Presentation
  富山国際会議場（富山県富山市）
- Year and Date
  2015-09-07
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] 多様なイソプレノイド生合成機構とその関連遺伝子2015
- Author(s)
  葛山智久
- Organizer
  千葉工大フォーラム
- Place of Presentation
  千葉工業大学（千葉県習志野市）
- Year and Date
  2015-06-19
- Invited
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] イソプレノイド生合成経路の収斂進化2015
- Author(s)
  葛山智久
- Organizer
  日本分子生物学会
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Year and Date
  2015-12-01
- Invited
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] An Unusual Terpene Cyclization Mechanism Involving a Carbon－Carbon Bond Rearrangement2015
- Author(s)
  Tomohisa Kuzuyama
- Organizer
  TERPNET2015
- Place of Presentation
  バンクーバー（カナダ）
- Year and Date
  2015-06-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] 放線菌由来テルペノイド生合成マシナリーの解明2014
- Author(s)
  葛山智久
- Organizer
  科研費新学術領域「生合成マシナリー」第８回公開シンポジウム
- Place of Presentation
  東京大学薬学部講堂（東京都文京区）
- Year and Date
  2014-12-06
- Invited
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] Biosynthesis of anti-influenza virus diterpene wickerols and other terpenoids produced by Trichoderma atroviride FKI-38492014
- Author(s)
  寺本和矢、西山真、葛山智久
- Organizer
  第14回東京大学生命科学シンポジウム
- Place of Presentation
  東京大学伊藤国際学術研究センター（東京都文京区）
- Year and Date
  2014-04-26
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] Biosynthesis of anti-influenza virus diterpene wickerols and other terpenoids produced by Trichoderma atroviride FKI-38492014
- Author(s)
  寺本和矢、西山真、葛山智久
- Organizer
  第3回生物生産工学研究センター研究発表会
- Place of Presentation
  東京大学農学部一条ホール（東京都文京区）
- Year and Date
  2014-04-22
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] Biosynthesis of terpenoids produced by Streptomyces2014
- Author(s)
  Tomohisa Kuzuyama
- Organizer
  Simposium Nasional Kimia Bahan Alam XXII
- Place of Presentation
  バンドン（インドネシア）
- Year and Date
  2014-10-21
- Invited
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] 放線菌由来環状天然化合物の骨格形成機構の解明2014
- Author(s)
  葛山智久
- Organizer
  生物生産工学研究センターシンポジウム
- Place of Presentation
  東京大学農学部一条ホール（東京都文京区）
- Year and Date
  2014-12-08
- Invited
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] メバロン酸経路の新規初発反応と反応機構の解明2010
- Author(s)
  岡村英治、富田武郎、澤竜一、西山真、葛山智久
- Organizer
  第52回天然有機化合物討論会
- Place of Presentation
  静岡県コンベンションアーツセンター(静岡県)
- Year and Date
  2010-09-30
- Data Source
  KAKENHI-PROJECT-21380071
[Presentation] Functional characterization of Streptomyces ABBA prenyltransferases in the biosyntheses of naphthoquinone derivatives and novobiocin2010
- Author(s)
  Tomohisa Kuzuyama
- Organizer
  60^<th> SIM Annual Meeting
- Place of Presentation
  San Francisco Convention Center (USA)(招待講演)
- Year and Date
  2010-08-03
- Data Source
  KAKENHI-ORGANIZER-22108001
[Presentation] 放線菌のメバロン酸経路遺伝子クラスターに見出した新規チオラーゼスーパーファミリー2010
- Author(s)
  葛山智久
- Organizer
  日本農芸化学会2010年度大会シンポジウム
- Place of Presentation
  東京
- Year and Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-21380071
[Presentation] Unusual cyclization mechanism of Streptomyces terpene cyclases
- Author(s)
  Tomohisa Kuzuyama
- Organizer
  Natural Product Discovery in the Post Genomic Era
- Place of Presentation
  サンディエゴ（米国）
- Year and Date
  2015-01-11 – 2015-01-15
- Invited
- Data Source
  KAKENHI-PROJECT-26292058

1. EGUCHI Tadashi (60201365)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
2. ABE Ikuro (40305496)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. DAIRI Tohru (70264679)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. IKEDA Haruo (90159632)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
5. SAITO Kazuki (00146705)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. MATSUNAGA Shigeki (60183951)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. GOMI Katsuya (60302197)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. KANAYA Shigehiko (90224584)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. ISHIKAWA Jun (40202957)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. SETO Haruo (10013335)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. FURIHATA Kazuo (20219091)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. SHIN-YA Kazuo (20251481)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. HAYAKAWA Yoichi (20208606)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. 高橋洋子 (80197186)

# of Collaborated Projects: 2 results

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# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
24. OIKAWA Hideaki (00185175)

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# of Collaborated Products: 1 results

Kuzuyama Tomohisa 葛山 智久

KUZUYAMA Tomohisa 葛山 智久

Research Projects

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Co-Researchers

Systems biosynthetics based on accumulation, prediction, and creation of biological reactionsArea Organizer

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予知生合成科学・研究総括班Principal Investigator

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構造多様性一挙構築型生体反応の集積・予知・創出Principal Investigator

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生物合成系の再設計による革新的核酸系化合物の創製Principal Investigator

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既存モチーフ配列を有さない革新的テルペン合成酵素の探索研究Principal Investigator

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メロテルペノイド生合成マシナリーの機能と構造に関する研究Host Researcher

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Redesigning Biosynthetic Machineries (Project Team)

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Development and precise functional analysis of innovative biosynthetic machinery to create complex skeletonsPrincipal Investigator

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生合成リデザイン・国際活動支援班

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Reaction mechanism of unique terpene synthases, that is elucidated by synthetic chemistry and structural biologyPrincipal Investigator

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Biosynthetic machinery: Deciphering and regulating the system for creating structural diversity of baioactive metabolites

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テルペンおよびヌクレオシド系抗生物質生合成マシナリーの解明とエンジニアリングPrincipal Investigator

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Search for anti-malaria agents from marine organisms

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Kuzuyama Tomohisa 葛山智久

KUZUYAMA Tomohisa 葛山智久