HORINOUTI Sueharu 堀之内末治

… Alternative Names

Researcher Number	80143410
External Links
Affiliation (based on the past Project Information) *help	2009 : 東京大学, 大学院・農学生命科学 2008 – 2009 : 東大, 農学生命科学研究科, 教授 2007 : The University of Tokyo, 大学院・農学生命科学研究科, 教授 2006 : 東京大学, 大学院農学生命科学研究科, 教授 1996 – 2005 : 東京大学, 大学院・農学生命科学研究科, 教授 … More
Review Section/Research Field	Principal Investigator 応用微生物学・応用生物化学 / Biological Sciences / 発酵・醸造 / Applied microbiology / 応用微生物学・発酵学 Except Principal Investigator 発酵・醸造 / 応用微生物学・発酵学 / Biological Sciences / 応用微生物学・応用生物化学 / Bioorganic chemistry
Keywords	Principal Investigator 放線菌 / 形態分化 / 二次代謝 / A-ファクター / 抗生物質生産 / Streptomyces / Streptomyces griseus / A-factor / 抗生物質 / 自己調節因子 … More Except Principal Investigator 細胞周期 / ヒストンアセチル化 / 分裂酵母 / 共生 / トリコスタチン / レプトマイシン / HDAC / FK228 / SCOP / リグノセルロ-ス / Saccharomyces cerevisiae / 爆砕 / エタノ-ル / キシロ-ス / symbiosis / Biosensor / NMR / セルラ-ゼ / キシラン / セルラーゼ / 絶対共生細菌 / 凝乳酵素 / トラポキシン / リグニンペルオキシダ-ゼ / unsaturated fatty acid synthetase / 免疫寛容 / 糖タンパク質 / inclusior body / 免疫系 / 細胞死 / トリプトファナーゼ / がん遺伝子 / 多倍体 / 遺伝子発現 / Hsp70 / Transcriptional factor / cdc mutant / amine oxidase / 多剤耐性遺伝子 / 反応遷移状態 / Enzyme activity / tryptophan / Histone acetylation / プロドラッグ / グルタチオン / ヒストンデアセチラーゼ / トランスジェニックマウス / 16 sDNA / RNAプロセシング / キシラーゼ / クロマチン / 核外移行 / バイオセンサー / 細胞導入 / β-チロシナーゼ / Site-directed mutagenesis / ミドカイン / 染色体高次構造 / Polycomb genes / アスパラギン酸プロテア-ゼ / two-hybrid system / プロテインキナ-ゼ / 微小管 / 酸化還元 / バイオモニタリング / 酵素活性 / 核外移行シグナル / 遺伝子ターゲティング / Ras / ラディシコ-ル / 生合成遺伝子 / Flow cytometry / Staurosporine / 転写制御 / サブサイト / ACETYLATION / Protein interaction / 植物 / ポリコ-ム遺伝子 / cloning / 糖鎖 / 遺伝子クロ-ニング / チューブリン / アクチンストレスファイバー / B cell / 温度感受性突然変異体 / GnT-III / CYCLIC TETRAPEPTIDES / グリコシルトランスフェラーゼ遺伝子 / Protein kinase / アセチル化 / リグノセルロース / taka-amylaseA / cellulase / ベイシジン / パーオキシダーゼ / カルボキシペプチダーゼ / シアル酸転移酵素 / 水晶体特異的遺伝子発現 / 16sDNA / 水蒸気爆砕 / 分子相互作用 / 転写因子 / Inclusion body / radicicol / 生合成酵素 / DRUG DESIGN / 不飽和脂肪酸合成酵素 / 遺伝子クローニング / ドラッグデザイン / キシロース / CRM1 / 免疫病 / 抽出発酵 / 耐熱性 / 多剤耐性 / エンドサイトーシス / キチン合成・分解酵素 / 蛋白質工学 / チロシンキナ-ゼ / アポトーシス / チオール / gene / シアリルルイスX / Transgenics / MICROTUBULE / Morphogenesis / サイクリン依存症キナーゼ / THIOL / シアリダーゼ / Trichostatin / heat-stable enzyme / チロシンキナーゼ / Symbiobacterium / growth factor / エタノール / Prochymosin / 酸性プロテアーゼ / thermophile / β-チロシナ-ゼ / 好熱菌 / preussin / タカアミラーゼA / P‐糖蛋白質 / B細胞 / Cre-IoxP / ムコ-ルレンニン / トリプトファン / 高等植物 / 活性天然物 / 発現 / シグナル伝達 / アミン酸化酵素 / 糸状菌 / DNA再複製 / 胚形成 / ATPase / 発生工学 / 生合成工学 / Cell cycle control / 好熱性共生細菌 / クローン化 / CDK / リフォ-ルディング / 糖鎖遺伝子 / 形態形成 / クローニング / caroxypeptidase / gene structure and expression in filamentous fingi / 遺伝子標的 / Site directed mutagenesis / Leptomycin / Cre-loxP / 耐熱性酵素 / Preussin / ヒストン / 代謝制御 / 二次代謝 / 癌細胞 / Crystallin gene / Radicicol / 蛋白高次機能構造 / Gal転移酵素 / 有機リン系農薬センサー / キチン合成酵素 / α1-6フコシルトランスフェラーゼ / T細胞 / チロシン77 / キモシン / chitin synthetase / 環状テトラペプチド / 倍数性 / Immunological tolerance / Gene targeting / 遺伝子 / 部位指定変異 / MAPキナーゼ / タカアミラーゼA遺伝子 / ラディシコール / チトクロームP-450 / chymosin / tryptophanase / 部位特異的変異 / 絶体共生細菌 / リフォ-ルデイング / 糸状菌遺伝子の構造と発現制御 / T細胞受容体 / バイオテクノロジー / inclusion body / T cell / Higher plants / 蛋白工学 / トリプトファナ-ゼ / Fission yeast / プロキモシン Less

放線菌の二次代謝、形態分化を司る制御機構の統括的解明Principal Investigator
- Principal Investigator
  
  堀之内末治
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Applied microbiology
- Research Institution
  The University of Tokyo
High efficient production of secondary metabolites on the basis of genomes of StreptomycesPrincipal Investigator
- Principal Investigator
  
  IKEDA Haruo, 堀之内末治
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kitasato University
  The University of Tokyo
放線菌ストレプトミセス・グリセウスのA‐ファクター制御カスケードの網羅的解明Principal Investigator
- Principal Investigator
  
  堀之内末治
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
微生物カルモジュリン:放線菌における増殖、形態分化の制御Principal Investigator
- Principal Investigator
  
  堀之内末治
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Applied microbiology
- Research Institution
  The University of Tokyo
放線菌ストレプトミセス・グリセウスのA-ファクター制御カスケードの網羅的解明Principal Investigator
- Principal Investigator
  
  堀之内末治
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
放線菌ストレプトミセス・グリセウスのA-ファクター制御カスケードの網羅的解明Principal Investigator
- Principal Investigator
  
  堀之内末治
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
カルモジュリン制御のプロトタイプ:放線菌における二次代謝、形態分化の制御Principal Investigator
- Principal Investigator
  
  堀之内末治
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  応用微生物学・応用生物化学
- Research Institution
  The University of Tokyo
放線菌ストレプトミセス・グリセウスのゲノム解析のための基盤研究Principal Investigator
- Principal Investigator
  
  堀之内末治
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
人工的生合成遺伝子クラスターを賦与した放線菌によるフラボノイド化合物の発酵生産Principal Investigator
- Principal Investigator
  
  堀之内末治
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  応用微生物学・応用生物化学
- Research Institution
  The University of Tokyo
Comprehensive study on regulatory systems for the initiation of secondary metabolism and morphological development in StreptomycesPrincipal Investigator
- Principal Investigator
  
  HORINOUCHI Sueharu
- Project Period (FY)
  2001 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  応用微生物学・応用生物化学
- Research Institution
  The University of Tokyo
放線菌ストレプトミセス・グリセウスのゲノム解析のための基盤整備Principal Investigator
- Principal Investigator
  
  堀之内末治
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
DEVELOPMENT OF CANCER THERAPEUTICS BASED ON REGULATION OF CHROMATIN STRUCTURE AND FUNCTION
- Principal Investigator
  
  YOSHIDA Minoru
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  RIKEN
  The University of Tokyo
放線菌のカルコン合成酵素様遺伝子を用いたフラボノイド醗酵生産の基盤研究Principal Investigator
- Principal Investigator
  
  堀之内末治
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  応用微生物学・応用生物化学
- Research Institution
  The University of Tokyo
Studies on the structure and function of A-factor receptor based on its X-ray crystallographic structurePrincipal Investigator
- Principal Investigator
  
  HORINOUCHI Sueharu
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (A).
- Research Field
  
  応用微生物学・応用生物化学
- Research Institution
  THE UNIVERSITY OF TOKYO
コンビナトリアル生合成法によるフラボノイドの発酵生産Principal Investigator
- Principal Investigator
  
  堀之内末治
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  応用微生物学・応用生物化学
- Research Institution
  The University of Tokyo
細胞周期と細胞死のシグナル伝達阻害剤の開発とその分子作用機構
- Principal Investigator
  
  吉田稔
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokyo
Japan-UK Joint Study on Molecular Genetics of StreptomycesPrincipal Investigator
- Principal Investigator
  
  HORINOUCHI Sueharu
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  応用微生物学・応用生物化学
- Research Institution
  The University of Tokyo
Studies on A-factor receptor protein involved in secondary metabolism and morphorogical differentiation in Streptomyces griseusPrincipal Investigator
- Principal Investigator
  
  HORINOUCHI Sueharu
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  応用微生物学・応用生物化学
- Research Institution
  The University of Tokyo
Study on the genetics of acetic acid bacteria for the efficient vinegar productionPrincipal Investigator
- Principal Investigator
  
  HORINOUCHI Sueharu
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用微生物学・応用生物化学
- Research Institution
  The University of Tokyo
細胞周期の分子機構とその抑制剤の開発
- Principal Investigator
  
  吉田稔
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
Regulation of Gene Expression
- Principal Investigator
  
  TANIGUCHI Masaru
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Chiba University, School of Medicine
天然物の生合成機構とその人為的制御
- Principal Investigator
  
  柿沼勝巳
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Tokyo Institute of Technology
Regulation of secondary metabolism and cell differentiation by A-factor and protein phosphorylation in Streptomyces.Principal Investigator
- Principal Investigator
  
  HORINOUCHI Sueharu
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  応用微生物学・応用生物化学
- Research Institution
  The University of Tokyo
Improvement of milk-clotting enzyme, Mucor rennin, by protein engineering and 「genetic engineering.Principal Investigator
- Principal Investigator
  
  HORINOUCHI Sueharu
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  応用微生物学・応用生物化学
- Research Institution
  The University of Tokyo
Analysis of a growth factor of a thermophilic symbiotic bacteria
- Principal Investigator
  
  BEPPU Teruhiko
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  応用微生物学・応用生物化学
- Research Institution
  Nihon University
新しいG1,G2期特異的細胞周期阻害剤の探索とそれを用いた増殖制御機構の解析
- Principal Investigator
  
  別府輝彦
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
糖鎖遺伝子の特異性
- Principal Investigator
  
  谷口直之
- Project Period (FY)
  1993 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
Regulation of Gene Expression
- Principal Investigator
  
  TANIGUCHI Masaru
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Chiba University
Genetical and biochemical analyzes of multiple functions in filamentous fungi
- Principal Investigator
  
  TSUKAGOSHI Norihiro
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  応用微生物学・発酵学
- Research Institution
  NAGOYA UNIVERSITY
Regulation of secondary metabolism and cellular differentiation by A-factor and signal transduction systems in StreptomycesPrincipal Investigator
- Principal Investigator
  
  HORINOUCHI Sueharu
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  応用微生物学・発酵学
- Research Institution
  The University of Tokyo
リグノセルロ-ス資源の生物燃料への変換
- Principal Investigator
  
  吉田敏臣
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
新しいG1,G2期特異的細胞周期阻害剤の探索とそれを用いた増殖制御機構の解析
- Principal Investigator
  
  別府輝彦
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
リグノセルロ-ス資源の生物燃料への変換
- Principal Investigator
  
  吉田敏臣
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
新しいG_1,G_2期特異的細胞周期阻害剤の探索とそれを用いた増殖制御機構の解析
- Principal Investigator
  
  BEPPU Teruhiko
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
ウシキモシンおよびムコ-ルレンニンの蛋白工学的研究
- Principal Investigator
  
  別府輝彦
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  応用微生物学・発酵学
- Research Institution
  The University of Tokyo
リグノセルロース資源の生物燃料への変換
- Principal Investigator
  
  吉田敏臣
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
放線菌の化学調節物質Aーファクタ-をめぐる調節ネットワ-クに関する研究Principal Investigator
- Principal Investigator
  
  堀之内末治
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  発酵・醸造
- Research Institution
  The University of Tokyo
絶対共生細菌の生産する耐熱性β-チロシナ-ゼ遺伝子のクロ-ン化と共生機構の解明
- Principal Investigator
  
  別府輝彦
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  発酵・醸造
- Research Institution
  The University of Tokyo
カルバペネム生産性放線菌における微量調節因子に関する研究Principal Investigator
- Principal Investigator
  
  堀之内末治
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  発酵・醸造
- Research Institution
  The University of Tokyo
諸外国におけるバイオサイエンスの研究動向調査
- Principal Investigator
  
  軽部征夫
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Overseas Scientific Research
Improvement and reconstitution of procymosin by recombinant DNA techniques
- Principal Investigator
  
  BEPPU Teruhiko.
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  発酵・醸造
- Research Institution
  The University of Tokyo
Cloning of a gene for heat-stable tryptophanase produced by an obligatorily symbiotic and thermophilic bacterium.
- Principal Investigator
  
  UOZUMI Takeshi
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  発酵・醸造
- Research Institution
  The University of Tokyo

All 2009 2008 2007 2006 2005 2004 2003 2002 2001

All Journal Article Presentation Book

[Book] Chemical Communication among Bacteria2008
- Author(s)
  Sueharu Horinouchi
- Total Pages
  15
- Publisher
  American Society for Microbiology
- Data Source
  KAKENHI-PROJECT-17019009
[Book] 「農芸化学の事典」(鈴木昭憲, 荒井綜一編)2003
- Author(s)
  堀之内末治
- Publisher
  朝倉書店、東京
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13854005
[Book] Encyclopedia of Agricultural Chemistry2003
- Author(s)
  Sueharu Horinouchi
- Publisher
  Asakura-shoten
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13854005
[Journal Article] Identification and gene disruption of small noncoding RNAs in Streptomyces griseus.2009
- Author(s)
  Tezuka T, Hara H.Ohnishi Y, Horinouchi S
- Journal Title
  
  J.Bacteriol. 191
  
  Pages : 4896-4904
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019009
[Journal Article] Enzymatic synthesis of bis-5-alkylresorcinols by resorcinol-producing type III polyketide synthases.2009
- Author(s)
  Miyanaga, A., Horinouchi, S.
- Journal Title
  
  J. Antibiot 62
  
  Pages : 371-376
- Data Source
  KAKENHI-PROJECT-17019009
[Journal Article] CebR as a master regulator for cellulose/cellooligosaccharide catabolism affects morphological development in Streptomyces griseus.2009
- Author(s)
  Marushima, K., Ohnishi, Y., Horinouchi, S.
- Journal Title
  
  J. Bacteriol 191
  
  Pages : 5930-5940
- Data Source
  KAKENHI-PROJECT-17019009
[Journal Article] Identification and characterization of target genes of the GinI/GinR quorum-sensing system in Gluconacetobacter intermedius.2009
- Author(s)
  Iida A, Ohnishi Y, Horinouchi S
- Journal Title
  
  Microbiol. 155
  
  Pages : 3021-3032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019009
[Journal Article] Biosynthesis of aliphatic polyketides by type III polyketide synthase and methyltransferase in Bacillus subtilis.2009
- Author(s)
  Nakano, C., Ozawa, H., Akanuma, G., Funa, N., Horinouchi, S.
- Journal Title
  
  J. Bacteriol 191
  
  Pages : 4916-4923
- Data Source
  KAKENHI-PROJECT-17019009
[Journal Article] Dynamic changes in the extracellular proteome caused by absence of a pleiotropic regulator AdpA in Streptomyces griseus.2009
- Author(s)
  Akanuma, G., Hara, H., Ohnishi, Y., Horinouchi, S.
- Journal Title
  
  Mol. Microbiol 73
  
  Pages : 898-912
- Data Source
  KAKENHI-PROJECT-17019009
[Journal Article] Enzymatic synthesis of bis-5-alkylresorcinols by resorcinol-Producing type III polyketide synthases.2009
- Author(s)
  Miyanaga A, Horinouchi S
- Journal Title
  
  J.Antibiot. 62
  
  Pages : 371-376
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019009
[Journal Article] DNA microarray analysis of global gene regulation by A-factor in Streptomyces griseus.2009
- Author(s)
  Hara, H., Ohnishi, Y., Horinouchi, S.
- Journal Title
  
  Microbiology 155
  
  Pages : 2197-2210
- Data Source
  KAKENHI-PROJECT-17019009
[Journal Article] Combinatorial biosynthesis of plant medicinal polyketides by microorganisms. Curr.2009
- Author(s)
  Horinouchi, S.
- Journal Title
  
  Opin. Chem. Biol. 13
  
  Pages : 197-204
- Data Source
  KAKENHI-PROJECT-17019009
[Journal Article] Biosynthesis of aliphatic polyketides by type III polyketide synthase and methyltransferase in Bacillus subtilis.2009
- Author(s)
  Nakano C, Ozawa H, Akanuma G, Funa N, Horinouchi S
- Journal Title
  
  J.Bacteriol. 191
  
  Pages : 4916-4923
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019009
[Journal Article] Identification and gene disruption of small noncoding RNAs in Streptomyces griseus.2009
- Author(s)
  Tezuka, T., Hara, H., Ohnishi, Y., Horinouchi, S.
- Journal Title
  
  J. Bacteriol 191
  
  Pages : 4896-4904
- Data Source
  KAKENHI-PROJECT-17019009
[Journal Article] Curcuminoid biosynthesis by two type III polyketide synthases in the herb Curcuma longa.2009
- Author(s)
  Katsuyama Y, Kita T, Funa N, Horinouchi S
- Journal Title
  
  J.Biol.Chem. 284
  
  Pages : 11160-11170
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019009
[Journal Article] Physically discrete beta-lactamase-type thioesterase catalyzes product release in atrochrysone synthesis by iterative type I polyketide synthase.2009
- Author(s)
  Awakawa T, Yokota K, Funa N, Doi F, Mori N, Watanabe H, Horinouchi S
- Journal Title
  
  Chem.Biol. 161
  
  Pages : 613-623
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019009
[Journal Article] Curcuminoid biosynthesis by two type III polyketide synthases in the herb Curcuma longa.2009
- Author(s)
  Katsuyama, Y., Kita, T., Funa, N., Horinouchi, S.
- Journal Title
  
  J. Biol. Chem. 284
  
  Pages : 11160-11170
- Data Source
  KAKENHI-PROJECT-17019009
[Journal Article] Combinatorial biosynthesis of Plant medicinal polyketides by microorganisms.2009
- Author(s)
  Horinouchi S
- Journal Title
  
  Curr.Opin.Chem.Biol. 13
  
  Pages : 197-204
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019009
[Journal Article] Identification and characterization of multiple curcumin synthases from the herb Curcuma longa.2009
- Author(s)
  Katsuyama, Y., Kita, T., Horinouchi, S.
- Journal Title
  
  FEBS Lett. 583
  
  Pages : 2799-2803
- Data Source
  KAKENHI-PROJECT-17019009
[Journal Article] Physically discrete beta-lactamase-type thioesterase catalyzes product release in atrochrysone synthesis by iterative type I polyketide synthase.2009
- Author(s)
  Awakawa, T., Yokota, K., Funa, N., Doi, F., Mori, N., Watanabe, H., Horinouchi, S.
- Journal Title
  
  Chem. Biol. 16
  
  Pages : 613-623
- Data Source
  KAKENHI-PROJECT-17019009
[Journal Article] Identification and characterization of multiple curcumin synthases from the herb Curcuma longa.2009
- Author(s)
  Katsuyama Y, Kita T, Horinouchi S
- Journal Title
  
  FEBS Lett. 583
  
  Pages : 2799-2803
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019009
[Journal Article] CebR as a master regulator for cellulose/cellooligosaccharide catabolism affects morphological development in Streptomyces griseus.2009
- Author(s)
  Marushima K, Ohnishi Y, Horinouchi S
- Journal Title
  
  J.Bacteriol. 191
  
  Pages : 5930-5940
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019009
[Journal Article] Conditionally positive effect of the TetR-family transcriptional regulator AtrA on streptomycin production by Streptomyces griseus.2008
- Author(s)
  Hirano, S., Tanaka, K., Ohnishi, Y., Horinouchi, S.
- Journal Title
  
  Microbiology 154
  
  Pages : 905-914
- Data Source
  KAKENHI-PROJECT-17019009
[Journal Article] A novel pair of terminal protein and telomere-associated protein for replication of the linear chromosome of Streptomyces griseus.2008
- Author(s)
  Suzuki, H., Marushima, K., Ohnishi, Y., Horinouchi, S.
- Journal Title
  
  Biosci. Biotechnol. Biochem 72
  
  Pages : 2973-2980
- Data Source
  KAKENHI-PROJECT-17019009
[Journal Article]2008
- Author(s)
  Sueharu Horinouchi
- Journal Title
  
  Chemical Communication among Bacteria(American Society for Microbiology)
  
  Pages : 363-377
- Data Source
  KAKENHI-PROJECT-19208009
[Journal Article] Direct transfer of starter substrates from type I fatty acid synthase to type III polyketide synthases in phenolic lipid synthesis.2008
- Author(s)
  Miyanaga, A., Funa, N., Awakawa, T., Horinouchi, S.
- Journal Title
  
  Proc. Natl. Acad. Sci. 105
  
  Pages : 871-876
- Data Source
  KAKENHI-PROJECT-17019009
[Journal Article] Phenolic lipids synthesized by type III polyketide synthase confer penicillin resistance on Streptomyces griseus.2008
- Author(s)
  Funabashi, M., Funa, N., Horinouchi, S.
- Journal Title
  
  J. Biol. Chem. 283
  
  Pages : 13983-13991
- Data Source
  KAKENHI-PROJECT-17019009
[Journal Article] Production of curcuminoids by Escherichia coli containing an artificial biosynthesis pathway.2008
- Author(s)
  Katsuyama, Y., Matsuzawa, M., Funa, N., Horinouchi, S.
- Journal Title
  
  Microbiology 154
  
  Pages : 2620-2628
- Data Source
  KAKENHI-PROJECT-17019009
[Journal Article] Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350.2008
- Author(s)
  Ohnishi, Y., Ishikawa, J., Hara, H., Suzuki, H., Ikenoya, M., Ikeda, H., Yamashita, A., Hattori, M., Horinouchi, S.
- Journal Title
  
  J. Bacteriol 190
  
  Pages : 4050-4060
- Data Source
  KAKENHI-PROJECT-17019009
[Journal Article] 有用遺伝子の天然保存庫としての放線菌2006
- Author(s)
  堀之内末治
- Journal Title
  
  学術月報 58
  
  Pages : 762-766
- Data Source
  KAKENHI-PROJECT-17019009
[Journal Article] 放線菌機能の制御、発掘、応用2005
- Author(s)
  堀之内末治
- Journal Title
  
  バイオサイエンスとインダストリー 63
  
  Pages : 11-16
- Data Source
  KAKENHI-PROJECT-16013210
[Journal Article] Streptomyces as a reservoir of useful genes (in Japanese).2005
- Author(s)
  Sueharu Horinouchi
- Journal Title
  
  Gakujutu-Geppo 58
  
  Pages : 762-766
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13854005
[Journal Article] 有用遺伝子の天然保存庫としての放線菌2005
- Author(s)
  堀之内末治
- Journal Title
  
  学術月報 58
  
  Pages : 762-766
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13854005
[Journal Article] 放線菌機能の制御、発掘、応用2005
- Author(s)
  堀之内末治
- Journal Title
  
  バイオサイエンスとインダストリー 63
  
  Pages : 11-16
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13854005
[Journal Article] 放線菌機能の制御、発掘、応用2005
- Author(s)
  堀之内末治
- Journal Title
  
  バイオサイエンスとインダストリー 63
  
  Pages : 11-16
- Data Source
  KAKENHI-PROJECT-17019009
[Journal Article] Regulation, mining and polishing of Streptomyces functions (in Japanese).2005
- Author(s)
  Sueharu Horinouchi
- Journal Title
  
  Bioscience & Industry 63
  
  Pages : 11-16
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13854005
[Journal Article] 有用物質生産の場としての放線菌2004
- Author(s)
  堀之内末治
- Journal Title
  
  バイオサイエンスとインダストリー 59
  
  Pages : 526-529
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13854005
[Journal Article] 「目でみるバイオ」放線菌A-ファクター受容体の構造と機能2004
- Author(s)
  堀之内末治
- Journal Title
  
  バイオサイエンスとインダストリー 62
  
  Pages : 503-504
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13854005
[Journal Article] Structure and function of the A-factor receptor (in Japanese).2004
- Author(s)
  Sueharu Horinouchi
- Journal Title
  
  Bioscience & Industry 62
  
  Pages : 503-504
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13854005
[Journal Article] 「目でみるバイオ」放線菌A-ファクター受容体の構造と機能2004
- Author(s)
  堀之内末治
- Journal Title
  
  バイオサイエンスとインダストリー 62
  
  Pages : 503-504
- Data Source
  KAKENHI-PROJECT-13854005
[Journal Article] 「目でみるバイオ」放線菌A-ファクター受容体の構造と機能2004
- Author(s)
  堀之内末治
- Journal Title
  
  バイオサイエンスとインダストリー 62
  
  Pages : 503-504
- Data Source
  KAKENHI-PROJECT-16013210
[Journal Article] AfsR as an integrator of signals that are sensed by multiple serine/threonine kinases in Streptomyces coelicolor A3(2).2003
- Author(s)
  Sueharu Horinouchi
- Journal Title
  
  J.Ind.Microbiol.Biotechnol. 30
  
  Pages : 462-467
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13854005
[Journal Article] 放線菌の真核型キナーゼは飾りではなく生育必需品2003
- Author(s)
  堀之内末治
- Journal Title
  
  バイオサイエンスとインダストリー 61
  
  Pages : 330-331
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13854005
[Journal Article] Eukaryotic-type protein kinases in Streptomyces are never accessories but necessaries for health growth (in Japanese).2003
- Author(s)
  Sueharu Horinouchi
- Journal Title
  
  Bioscience & Industry 61
  
  Pages : 330-331
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13854005
[Journal Article] A microbial hormone, A-factor, as a master switch for morphological differentiation and secondary metabolism in Streptomyces griseus.2002
- Author(s)
  Sueharu Horinouchi
- Journal Title
  
  Front, Biosci. 7
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13854005
[Journal Article] A microbial hormone, A-factor, as a master switch for morphological differentiation and secondary metabolism in Streptomyces griseus.2002
- Author(s)
  Sueharu Horinouchi
- Journal Title
  
  Front.Biosci. 7
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13854005
[Journal Article] 原核と真核の境界微生物としての放線菌の形態分化2002
- Author(s)
  堀之内末治
- Journal Title
  
  日本農芸化学会誌 76
  
  Pages : 937-939
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13854005
[Journal Article] Morphogenesis of Streptomyces, a boundary microorganism (in Japanese).2002
- Author(s)
  Sueharu Horinouchi
- Journal Title
  
  Nippon Nogeikagaku-kaishi 76
  
  Pages : 937-939
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13854005
[Journal Article] Streptomyces as a factory for production of useful substances (in Japanese).2001
- Author(s)
  Sueharu Horinouchi
- Journal Title
  
  Bioscience & Industry 59
  
  Pages : 526-529
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13854005
[Journal Article] The A-factor regulatory cascade and cAMP in the regulation of physioligical and morpholigical development in Streptomyces griseus.2001
- Author(s)
  Sueharu Horinouchi
- Journal Title
  
  J. Ind. Microbiol. Biotechnol. 27
  
  Pages : 177-182
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13854005
[Journal Article] The A-factor regulatory cascade and cAMP in the regulation of physiological and morphological development in Streptomyces griseus.2001
- Author(s)
  Sueharu Horinouchi
- Journal Title
  
  J.Ind.Microbiol.Biotechnol. 27
  
  Pages : 177-182
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13854005
[Presentation] 放線菌遺伝子のコンビナトリアル生合成への利用2007
- Author(s)
  堀之内末治
- Organizer
  福山大学グリーンサイエンス研究センター公開講演会-土壌細菌の底力:放線菌と枯草菌-
- Place of Presentation
  福山大学
- Year and Date
  2007-09-15
- Data Source
  KAKENHI-PROJECT-17019009
[Presentation] コンビナトリアル生合成と微生物2007
- Author(s)
  堀之内末治
- Organizer
  豊かな社会を創造する科学技術シンポジウム、長瀬科学技術振興財団
- Place of Presentation
  大阪国際交流センター
- Year and Date
  2007-09-30
- Data Source
  KAKENHI-PROJECT-17019009
[Presentation] コンビナトリアル生合成と微生物2007
- Author(s)
  堀之内末治
- Organizer
  豊かな社会を創造する科学技術シンポジウム、長瀬科学技術振興財団
- Place of Presentation
  大阪国際交流センター
- Year and Date
  2007-09-30
- Data Source
  KAKENHI-PROJECT-19208009
[Presentation] 放線菌遺伝子のコンビナトリアル生合成への利用2007
- Author(s)
  堀之内末治
- Organizer
  福山大学グリーンサイエンス研究センター公開講演会-土壌細菌の底力:放線菌と枯草菌-
- Place of Presentation
  福山大学
- Year and Date
  2007-09-15
- Data Source
  KAKENHI-PROJECT-19208009
[Presentation] 「非微生物型」物質の微生物による発酵生産2007
- Author(s)
  堀之内末治
- Organizer
  Arnold L. Demain 先生の傘寿を祝う講演会、日本放線菌学会
- Place of Presentation
  北里研究所
- Year and Date
  2007-11-30
- Data Source
  KAKENHI-PROJECT-19208009
[Presentation] 「非微生物型」物質の微生物による発酵生産2007
- Author(s)
  堀之内末治
- Organizer
  Arnold L. Demain先生の傘寿を祝う講演会、日本放線菌学会
- Place of Presentation
  北里研究所
- Year and Date
  2007-11-30
- Data Source
  KAKENHI-PROJECT-17019009

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HORINOUTI Sueharu 堀之内 末治

堀ノ内 末治 ホリノウチ スエハル

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Co-Researchers

放線菌の二次代謝、形態分化を司る制御機構の統括的解明Principal Investigator

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High efficient production of secondary metabolites on the basis of genomes of StreptomycesPrincipal Investigator

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放線菌ストレプトミセス・グリセウスのA‐ファクター制御カスケードの網羅的解明Principal Investigator

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微生物カルモジュリン:放線菌における増殖、形態分化の制御Principal Investigator

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放線菌ストレプトミセス・グリセウスのA-ファクター制御カスケードの網羅的解明Principal Investigator

Principal Investigator

Project Period (FY)

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放線菌ストレプトミセス・グリセウスのA-ファクター制御カスケードの網羅的解明Principal Investigator

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カルモジュリン制御のプロトタイプ:放線菌における二次代謝、形態分化の制御Principal Investigator

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放線菌ストレプトミセス・グリセウスのゲノム解析のための基盤研究Principal Investigator

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人工的生合成遺伝子クラスターを賦与した放線菌によるフラボノイド化合物の発酵生産Principal Investigator

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Comprehensive study on regulatory systems for the initiation of secondary metabolism and morphological development in StreptomycesPrincipal Investigator

Principal Investigator

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放線菌ストレプトミセス・グリセウスのゲノム解析のための基盤整備Principal Investigator

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DEVELOPMENT OF CANCER THERAPEUTICS BASED ON REGULATION OF CHROMATIN STRUCTURE AND FUNCTION

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放線菌のカルコン合成酵素様遺伝子を用いたフラボノイド醗酵生産の基盤研究Principal Investigator

Principal Investigator

Project Period (FY)

HORINOUTI Sueharu 堀之内末治

堀ノ内末治ホリノウチスエハル