SAKAMOTO HIROSHI 坂本博

… Alternative Names

SAKAMOTO Hiroshi 坂本博

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Researcher Number	00187048
Other IDs
Affiliation (Current)	2025: 九州医療科学大学, 生命医科学部, 教授
Affiliation (based on the past Project Information) *help	2016 – 2019: 神戸大学, 理学研究科, 教授 2011 – 2016: 神戸大学, 理学(系)研究科(研究院), 教授 1999 – 2007: Kobe University, Faculty of Science, Professor, 理学部, 教授 1992 – 1998: 神戸大学, 理学部, 助教授 1987 – 1991: 京都大学, 理学部, 助手
Review Section/Research Field	Principal Investigator Molecular biology / Biological Sciences / Developmental biology / Molecular biology / 幹細胞生物学 / Genome biology / Genome biology / 分子遺伝学・分子生理学 Except Principal Investigator Biological Sciences
Keywords	Principal Investigator RNA結合蛋白質 / Hu蛋白質 / 神経細胞 / スプライシング / 生殖細胞 / 始原生殖細胞 / 線虫 / RNA-binding protein / AU-rich element / 細胞内局在 … More / 神経分化 / 蛋白質間相互作用 / Sxl蛋白質 / ショウジョウバエ / クロモドメイン蛋白質 / MRG-1 / クロモドメインタンパク質 / neuron / in vitro selection / 翻訳制御 / ゲノム / RNA結合ドメイン / 核外移行シグナル / ポリ(A)配列 / AU-rich配列 / 神経 / RNA結合特異性 / 性特異的スプライシング / mRNA安定性 / 3'非翻訳領域 / 細胞分化 / 細胞増殖 / スプライシング制御 / RNA / transcriptional regulation / chromatin remodeling / histone / mes genes / mep-1 gene / mrg-1 gene / primordial germ cell / 母性蛋白質 / 核局在 / ヒストンメチル化 / ヒストンアセチル化 / 転写活性化 / MEP-1 / 転写調節 / クロマチン再編成 / ヒストン / mes遺伝子 / mep-1遺伝子 / mrg-1遺伝子 / mRNA decay / meiosis / rRNA processing / germ cell / translational regulation / neuronal cell / 性分化 / クロモドメイン / mRNAの安定性 / 体細胞分裂 / リボソーム生合成 / mRNA核外輸送受容体 / NXF1 / TAP / Mmi1 / Mei2 / Huタンパク質 / 遺伝子発現抑制 / キャップ構造依存的翻訳 / HuD / mRNA分解 / 減数分裂 / rRNAプロセシング / RNA結合タンパク質 / protein-protein interaction / Hu protein / 免疫沈降法 / 線虫変異体 / P19 cell / PC12 cell / Subcellular localization / nuclear export signal / Hu proteins / 神経成長因子 / 生物学的機能 / 核移行シグナル / P19細胞 / PC12細胞 / poly (A) sequence / cDNA cloning / neuronal RNA binding protein / mouse / RRM / 神経特異的発現 / 選択的スプライシング / CDNA クローリング / 神経特異的RNA結合蛋白質 / マウス / RNAの核外輸送 / 品質管理 / 核外輸送 / RNAスプライシング / 遺伝子発現調節 / ゲノム機能発現 / 性決定 / 発現制御 / 核酸 / 遺伝子 / RNA品質管理 / 性決定遺伝子 / 異常スプライシング / 細胞質スプライシング / エキソン連結部複合体 / mRNA品質管理 / RNAinterference / 発生分化 / RNAi / リンカー領域 / アミノ酸置換 / 機能ドメイン / GFP蛍光 / ゲノムデータベース / HeLa細胞 / ポリメラーゼ連鎖反応 / RNAヘリカーゼ / スプライシングの活性化 / トランスフェクション法 / transformerー2遺伝子 / transformer遺伝子 / doublesex遺伝子 / スプライシング異常 / 知識情報処理 / デ-タベ-ス / エキソン予測 / 配列解析 / ゲノム解析 / ル-ルベ-ス・システム / RNA スプライシング … More Except Principal Investigator NMR / RNA / スプライシング / tRNA / データベース / 異常スプライシング / RNAスプライシング / レトロポゾン / Post-transcriptional Control / Translational Control / RAN Interference / Noncoding RNA / Molecular Mimicry / RNP Complex / Network / 翻訳調節 / 転写後調節 / RNA干渉 / ノンコーディングRNA / ポストゲノム / 分子擬態 / 高次複合機能 / RNA蛋白質複合体 / ネットワーク / Biosensor / Protein interaction / Gene targeting / Higher plants / Morphogenesis / Cre-loxP / Fission yeast / 植物 / 胚形成 / 蛋白高次機能構造 / 遺伝子ターゲティング / RNAプロセシング / バイオモニタリング / DNA再複製 / 細胞周期 / 温度感受性突然変異体 / ATPase / 免疫病 / 免疫系 / バイオセンサー / 分子相互作用 / 遺伝子標的 / 高等植物 / 形態形成 / Cre-IoxP / 分裂酵母 / sx1 protein / stable isotope labeling / base pairing / modified nucleoside / alternative splicing / splicing / ミトコンドリアtRNA / mRNAスプライシング / rRNA / RNA結合蛋白質 / ミトコンドリア / リボザイム / nRNAスプライシング / 機能構造 / 蛋白質 / 安定同位体標識 / 塩基対合 / 修飾ヌクレオシド / オルタナテイブスプライシング / RNAドメイン / 部異特異的突然変異導入法 / RNA触媒 / RNA・タンパク質複合体 / 核内キャップ構造結合タンパク質 / HeLa細胞核抽出液 / in vitro mRNAスプライシング反応系 / 部位特異的突然変異体生成法 / RNaseP-RNA成分 / 卵母細胞 / 核内キャップ構造認識因子 / ATP要求性 / ノースウエスタン法 / transformer(tra)遺伝子 / Sex-lethal(Sxl)遺伝子 / 二次構造 / マウス免疫グロブリンμ鎖遺伝子 / アビジンービオチンの特異的親和性 / 第二段階反応 / mRNA前駆体スプライシング反応 / 性決定遺伝子 / ショウジョウバエ / 免疫グロブリンμ鎖遺伝子 / オルタナティブスプライシング / U6snRNA / キャップ構造 / mRNA前駆体 / 選択的スプライシング / 配列解析 / ニュートラル・ネット / 反復配列 / 性決定 / 転移RNA / ドロソフィラ / イントロン / 逆転写 / RLVP / 自己切断 / リボゾ-ム / RNAワ-ル-ド Less

Elucidation of the regulatory mechanism of mRNA stability, which is essential for germ cell differentiation and growthPrincipal Investigator
- Principal Investigator
  
  Sakamoto Hiroshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Developmental biology
- Research Institution
  Kobe University
A novel function of RNA splicing in control of proliferation and differentiation of germ cellsPrincipal Investigator
- Principal Investigator
  
  SAKAMOTO HIROSHI
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Molecular biology
- Research Institution
  Kobe University
Mechanism of the nuclear retention of unspoiled RNAs that ensures proper expression of genomic informationPrincipal Investigator
- Principal Investigator
  
  Sakamoto Hiroshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Genome biology
- Research Institution
  Kobe University
Comprehensive identification of abnormally spliced RNAs and elucidation of their significancePrincipal Investigator
- Principal Investigator
  
  SAKAMOTO Hiroshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Genome biology
- Research Institution
  Kobe University
Analysis of the mrg-1 gene function required for differentiation of primordial germ cells in the nematode C.elegansPrincipal Investigator
- Principal Investigator
  
  SAKAMOTO Hiroshi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  幹細胞生物学
- Research Institution
  Kobe University
Regulative mechanisms of cell proliferation and differentiation by RNA-binding proteinsPrincipal Investigator
- Principal Investigator
  
  SAKAMOTO Hiroshi
- Project Period (FY)
  2002 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
線虫の発生分化過程におけるRNA結合蛋白質機能の網羅的解析Principal Investigator
- Principal Investigator
  
  坂本博
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
Spatiotemporal Network of RNA Information Flow
- Principal Investigator
  
  NAKAMURA Yoshikazu
- Project Period (FY)
  2001 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
RNA結合蛋白質Huの機能特異性を決定するアミノ酸残基の解析Principal Investigator
- Principal Investigator
  
  坂本博
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kobe University
線虫の発生分化過程におけるRNA結合蛋白質機能の網羅的解析Principal Investigator
- Principal Investigator
  
  坂本博
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
Functional analysis of Hu proteins that induce neuronal differentiationPrincipal Investigator
- Principal Investigator
  
  SAKAMOTO Hiroshi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Molecular biology
- Research Institution
  Kobe University
神経特異的HuD蛋白質の細胞内シャトリングシグナルの解析Principal Investigator
- Principal Investigator
  
  坂本博
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kobe University
神経特異的RNA結合蛋白質Huによる細胞分化誘導機構の解析Principal Investigator
- Principal Investigator
  
  坂本博
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kobe University
神経特異的Hu蛋白質の機能ドメイン構造の解析Principal Investigator
- Principal Investigator
  
  坂本博
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kobe University
Studies on the Biological Functions of Neuron-specific RNA-binding Proteins in Cultured CellsPrincipal Investigator
- Principal Investigator
  
  SAKAMOTO Hiroshi
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Molecular biology
- Research Institution
  Kobe University
GFP蛍光による線虫RNA結合蛋白質の網羅的発現部位解析手法の確立Principal Investigator
- Principal Investigator
  
  坂本博
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Molecular biology
- Research Institution
  Kobe University
ショウジョウバエSxl蛋白質のRNA結合特異性と蛋白質間相互作用Principal Investigator
- Principal Investigator
  
  坂本博
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kobe University
Structure, function and expression of the genes for mouse neuronal RNA-binding proteinsPrincipal Investigator
- Principal Investigator
  
  SAKAMOTO Hiroshi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Molecular biology
- Research Institution
  KOBE University
ショウジョウバエS×l遺伝子における性特異的スプライシング機構Principal Investigator
- Principal Investigator
  
  坂本博
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kobe University
データベースと人工知能を用いたRNAスプライス部位選択に関する研究
- Principal Investigator
  
  中井謙太
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Okazaki National Research Institutes
ショウジョウバエSxl遺伝子における性特異的スプライシング機構Principal Investigator
- Principal Investigator
  
  坂本博
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kobe University
スプライシングに関与するRNAヘリカーゼ遺伝子のクローニングPrincipal Investigator
- Principal Investigator
  
  坂本博
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Kobe University
Regulation of Gene Expression
- Principal Investigator
  
  TANIGUCHI Masaru
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Chiba University
データベースと人工知能を用いたRNAスプライス部位選択に関する研究
- Principal Investigator
  
  中井謙太
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Okazaki National Research Institutes
Mechanism of RNA function expression
- Principal Investigator
  
  WATANABE Kimitsuna
- Project Period (FY)
  1992 – 1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
RNAの新しい機能に関する研究
- Principal Investigator
  
  岡田典弘
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  University of Tsukuba
デ-タベ-スと人工知能を用いたRNAスプライス部位選択に関する研究Principal Investigator
- Principal Investigator
  
  坂本博
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
ショウジョウバエのdsx遺伝子における性特異的スプライシング機構の研究Principal Investigator
- Principal Investigator
  
  坂本博
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  分子遺伝学・分子生理学
- Research Institution
  Kyoto University
RNAの新しい機能に関する研究
- Principal Investigator
  
  岡田典弘
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  University of Tsukuba
遺伝子発現におけるRNAスプライシングの分子生物学的研究
- Principal Investigator
  
  SHIMURA Yoshiro
- Project Period (FY)
  1987 – 1990
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Research Institution
  Kyoto University

All 2019 2018 2017 2016 2015 2014 2013 2012 2011 2008 2007 2006 2005 2004 Other

All Journal Article Presentation

[Journal Article] MRG-1 is required for both chromatin-based transcriptional silencing and genomic integrity of primordial germ cells in C. elegans.2019
- Author(s)
  Miwa, T., Inoue, K., Sakamoto, H.
- Journal Title
  
  Genes to Cells
  
  Volume: 24 Issue: 5 Pages: 377-389
- DOI
  10.1111/gtc.12683
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07411, KAKENHI-PROJECT-17J02073
[Journal Article] Control of the heat stress-induced alternative splicing of a subset of genes by hnRNP K.2016
- Author(s)
  Yamamoto K, Furukawa M, Fukumura K, Kawamura A, Yamada T, Suzuki H, Hirose T, Sakamoto H, Inoue K.
- Journal Title
  
  Genes Cells.
  
  Volume: 21 Issue: 9 Pages: 1006-1014
- DOI
  10.1111/gtc.12400
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26113002, KAKENHI-PROJECT-26290062, KAKENHI-PROJECT-26291001, KAKENHI-PROJECT-15K14451
[Journal Article] The Exon Junction Complex controls the efficient and faithful splicing of a subset of transcripts involved in mitotic cell-cycle progression.2016
- Author(s)
  Fukumura, K., Wakabayashi, S., Kataoka, N., Sakamoto, H., ;Suzuki, Y., ;Nakai, K., Mayeda, A., Inoue, K.
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 17 Issue: 8 Pages: 1153-1153
- DOI
  10.3390/ijms17081153
- NAID
  120005838148
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26290062, KAKENHI-PROJECT-15K14451
[Journal Article] Interaction and colocalization of HERMES/RBPMS with NonO, PSF, and G3BP1 in neuronal cytoplasmic RNP granules in mouse retinal line cells.2015
- Author(s)
  Furukawa, M.T., Sakamoto, H., and Inoue, K.
- Journal Title
  
  Genes to Cells
  
  Volume: 20 Issue: 4 Pages: 257-266
- DOI
  10.1111/gtc.12224
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25290076, KAKENHI-PROJECT-26290062, KAKENHI-PROJECT-14J04370
[Journal Article] Restricted distribution of mrg-1 mRNA in C. elegans primordial germ cells through germ granule-independent regulation2015
- Author(s)
  Miwa, T., Takasaki, T., Inoue, K., Sakamoto, H.
- Journal Title
  
  Genes to Cells
  
  Volume: 20 Issue: 11 Pages: 932-942
- DOI
  10.1111/gtc.12285
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K14451, KAKENHI-PROJECT-26290062
[Journal Article] Developmental expression and evolution of muscle-specific microRNA s conserved in vertebrates.2013
- Author(s)
  Saori Tani, Shigehiro Kuralcu, Hiroshi Sakamoto, Kunio Inoue and Rie Kusakabe.
- Journal Title
  
  Evolution & Development
  
  Volume: 15 Issue: 4 Pages: 293-304
- DOI
  10.1111/ede.12039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J02096, KAKENHI-PROJECT-23510234, KAKENHI-PROJECT-23770250, KAKENHI-PROJECT-25440108
[Journal Article] A specific set of EJC subunits is required for the nuclear retention of unspliced RNAs in C. elegans2013
- Author(s)
  Masami Shiimori, KunioInoue, Hiroshi Sakamoto
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: Jan ; 33(2) Issue: 2 Pages: 444-56
- DOI
  10.1128/mcb.01298-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J02501, KAKENHI-PROJECT-23510234, KAKENHI-PROJECT-24657118, KAKENHI-ORGANIZER-20112001, KAKENHI-PLANNED-20112003
[Journal Article] Functional and direct interaction between the RNA binding protein HuD and active Akt12012
- Author(s)
  Fujiwara, T., Fukao, A., Sasano, Y., Matsuzaki, H., Kikkawa, U., Imataka, A., Inoue, K., Endo, S., Sonenberg, N. Thoma, C., & Sakamoto, H.
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: 40 Pages: 1944-1953
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23510234
[Journal Article] Translational inhibition by deadenylation-independent mechanisms is central to microRNA-mediated silencing in zebrafish2012
- Author(s)
  Mishima, Y., Fukao, A., Kishimoto, T., Sakamoto, H., Fujiwara, T., Inoue, K.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: 109 Pages: 1104-1109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23510234
[Journal Article] VAB-10 spectraplakin acts in cell and nuclear migration in Caenorhabditis elegans2011
- Author(s)
  Kim HS, Murakami R, Quintin S, Mori M, Ohkura K, Tamai KK, Labouesse M, Sakamoto H, Nishiwaki K.
- Journal Title
  
  Development
  
  Volume: 138 Pages: 4013-4023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23510234
[Journal Article] Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G.2008
- Author(s)
  Miyakawa, S., Nomura, Y., Sakamoto, T., Yamaguchi, Y., Kato, K., Yamazaki, S., Nakamura, Y.
- Journal Title
  
  RNA (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13051101
[Journal Article] Structural and molecular basis for hyperspecificity of RNA aptamerto human immunoglobulin G.2008
- Author(s)
  Miyakawa, S., Nomura, Y., Sakamoto, T., Yamaguchi, Y., Kato, K., Yamazaki, S., Nakamura, Y.
- Journal Title
  
  RNA (Apr 25[Epub ahead of print])
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13051101
[Journal Article] Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G.2008
- Author(s)
  Miyakawa, S., Nomura, Y., Sakamoto, T., Yamaguchi, Y., Kato, K., Yamazaki, S., Nakamura, Y.
- Journal Title
  
  RNA Apr 25 (Epub ahead of print)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13051101
[Journal Article] Spatiotemporal localization of germ plasm RNAs during zebrafish oogenesis.2007
- Author(s)
  Kosaka, K., Kawakami, K., Sakamoto, H., Inoue, K.
- Journal Title
  
  Mech. Dev. 124
  
  Pages: 279-289
- Data Source
  KAKENHI-PROJECT-13051101
[Journal Article] MRG-1, an autosome-associated protein, silences X-linked genes and protects germline immortality in Caenorhabditis elegans.2007
- Author(s)
  Takasaki T., Liu, Z., Habara, Y., Nishiwaki, K., Nakayama, J., Inoue, K., Sakamoto, H., Strome, S.
- Journal Title
  
  Development 134
  
  Pages: 757-767
- Data Source
  KAKENHI-PROJECT-13051101
[Journal Article] Differential regulation of germline specific mRNAs in soma and primordial germ cells by zebrafish miR-430.2006
- Author(s)
  Mishima, Y., Giraldez, A.J., Takeda, Y., Fujiwara, T., Sakamoto, H., Schier, A.F., Inoue, K.
- Journal Title
  
  Current Biology 16
  
  Pages: 12135-21142
- Data Source
  KAKENHI-PROJECT-13051101
[Journal Article] NMR structures of double loops of an RNA aptamer against mammalian initiation factor 4A.2005
- Author(s)
  Sakamoto, T., Oguro, A., Kawai, G., Sonenberg, N., Ohtsu, T., Nakamura, Y.
- Journal Title
  
  Nucl. Acids Res. 33
  
  Pages: 745-754
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13051101
[Journal Article] NMR structures of double loops of an RNA aptamer against mammalian initiation factor 4A.2005
- Author(s)
  Sakamoto, T.
- Journal Title
  
  Nucl.Acids Res. 33
  
  Pages: 745-754
- Data Source
  KAKENHI-PROJECT-13051101
[Journal Article] NMR structures of double loops of an RNA aptamer against mammalian initiation factor 4A.2005
- Author(s)
  Sakamoto, T., Oguro, A., Kawai, G., Sonenberg, N., Ohtsu.T., Nakamura.Y.
- Journal Title
  
  Nucl.Acids Res. 33
  
  Pages: 745-754
- Data Source
  KAKENHI-PROJECT-13051101
[Journal Article] The Escherichia coli argU10 (Ts) phenotype is caused by a reduction in the cellular level of the argUt RNA for the rare codons AGA and AGG2004
- Author(s)
  K.Sakamoto
- Journal Title
  
  J.Bacteriol. 186
  
  Pages: 5899-5905
- Data Source
  KAKENHI-PROJECT-13051101
[Presentation] 線虫C. elegansにおいてクロモドメイン蛋白質MRG-1は始原生殖細胞における転写抑制制御に必要である2018
- Author(s)
  巳波孝至、高崎輝恒、井上邦夫、坂本博
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K07411
[Presentation] The chromodomain protein MRG-1 is required for global repression of Pol II-dependent transcription in the primordial germ cells in C. elegans2018
- Author(s)
  巳波孝至、井上邦夫、坂本博
- Organizer
  線虫研究の未来を創る会
- Data Source
  KAKENHI-PROJECT-17K07411
[Presentation] The chromodomain protein MRG-1 is required for global repression of Pol II-dependent transcription in the primordial germ cells in C. elegans2018
- Author(s)
  巳波孝至、高崎輝恒、井上邦夫、坂本博
- Organizer
  第70回日本細胞生物学会、第51回日本発生生物学会合同大会
- Data Source
  KAKENHI-PROJECT-17K07411
[Presentation] 熱ストレス応答性選択的スプライシング制御機構の解明2018
- Author(s)
  川浪巧、逵本実希、坂本博、井上邦夫
- Organizer
  第20回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-17K07411
[Presentation] Chromodomain protein MRG-1 is required for global repression of Pol II-dependent transcription in the primordial germ cells in C. elegans.2017
- Author(s)
  Miwa, T., Takasaki, T., Inoue, K., Sakamoto, H.
- Organizer
  第50回発生生物学会年会
- Data Source
  KAKENHI-PROJECT-17K07411
[Presentation] 線虫クロモドメイン蛋白質MRG-1は始原生殖細胞における転写抑制制御に必要である2017
- Author(s)
  巳波孝至、高崎輝恒、井上邦夫、坂本博
- Organizer
  第40回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K07411
[Presentation] 線虫始原生殖細胞におけるクロモドメイン蛋白質MRG-1の機能解析2017
- Author(s)
  巳波孝至、高崎輝恒、井上邦夫、坂本博
- Organizer
  関西地区線虫勉強会
- Data Source
  KAKENHI-PROJECT-17K07411
[Presentation] 線虫C.elegansの生殖細胞形成に必須なクロマチン制御因子群の始原生殖細胞への限局機構の解析2015
- Author(s)
  巳波孝至、高崎輝恒、井上邦夫、坂本博
- Organizer
  第17回RNA学会年会
- Place of Presentation
  ホテルライフォート札幌（北海道・札幌市）
- Year and Date
  2015-07-15
- Data Source
  KAKENHI-PROJECT-15K14451
[Presentation] 線虫C. elegansの始原生殖細胞成熟過程におけるクロマチン制御機構の研究2015
- Author(s)
  巳波孝至、高崎輝恒、井上邦夫、坂本博
- Organizer
  関西地区線虫勉強会
- Place of Presentation
  関西学院大学梅田キャンパス（大阪府・大阪市）
- Year and Date
  2015-10-15
- Data Source
  KAKENHI-PROJECT-26290062
[Presentation] 線虫C.elegansの生殖細胞形成に必須なクロマチン制御因子群の始原生殖細胞への限局機構の解析2015
- Author(s)
  巳波孝至、高崎輝恒、井上邦夫、坂本博
- Organizer
  第17回RNA学会年会
- Place of Presentation
  ホテルライフォート札幌（北海道・札幌市）
- Year and Date
  2015-07-15
- Data Source
  KAKENHI-PROJECT-26290062
[Presentation] 線虫C. elegansの生殖細胞形成に必須なクロマチン制御因子群の始原生殖細胞への限局機構の解析2015
- Author(s)
  巳波孝至、井上邦夫、坂本博、高崎輝恒
- Organizer
  第38回日本分子生物学会
- Place of Presentation
  神戸国際展示場（兵庫県・神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K14451
[Presentation] 線虫C. elegansの生殖細胞形成に必須なクロマチン制御因子群の始原生殖細胞への限局機構の解析2015
- Author(s)
  巳波孝至、井上邦夫、坂本博、高崎輝恒
- Organizer
  第38回日本分子生物学会
- Place of Presentation
  神戸国際展示場（兵庫県・神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26290062
[Presentation] 線虫C. elegansの始原生殖細胞成熟過程におけるクロマチン制御機構の研究2015
- Author(s)
  巳波孝至、高崎輝恒、井上邦夫、坂本博
- Organizer
  関西地区線虫勉強会
- Place of Presentation
  関西学院大学梅田キャンパス（大阪府・大阪市）
- Year and Date
  2015-10-15
- Data Source
  KAKENHI-PROJECT-15K14451
[Presentation] 線虫C. elegansにおけるRNAの輸送経路を決める機構の解析2014
- Author(s)
  相澤理丞、井上邦夫、坂本博
- Organizer
  関西地区線虫勉強会
- Place of Presentation
  関西学院大学梅田キャンパス、大阪市
- Year and Date
  2014-10-23
- Data Source
  KAKENHI-PROJECT-26290062
[Presentation] 線虫C.elegansにおける生殖細胞形成に関与するクロモドメインタンパクMRG-1の局在機構の解析2014
- Author(s)
  巳波孝至、高崎輝恒、坂本博
- Organizer
  関西地区線虫勉強会ジョイントミーティング
- Place of Presentation
  関西学院大学梅田キャンパス
- Data Source
  KAKENHI-PROJECT-23510234
[Presentation] 線虫C.elegans生殖細胞におけるスプライシング関連タンパク質リン酸化酵素SPK-1の機能解析2013
- Author(s)
  土橋匠、高崎輝恒、井上邦夫、坂本博
- Organizer
  RNAフロンティアミーティング2013
- Place of Presentation
  ラフォーレ修善寺　静岡県
- Data Source
  KAKENHI-PROJECT-23510234
[Presentation] 線虫C.elegans生殖細胞におけるスプライシング関連因子SPK-1の機能解析2013
- Author(s)
  土橋匠、高崎輝恒、井上邦夫、坂本博
- Organizer
  関西地区線虫勉強会ジョイントミーティング
- Place of Presentation
  関西学院大学梅田キャンパス
- Data Source
  KAKENHI-PROJECT-23510234
[Presentation] 線虫C.elegansにおけるRNAの輸送経路を決める機構の解析2013
- Author(s)
  相澤理丞、井上邦夫、坂本博
- Organizer
  RNAフロンティアミーティング2013
- Place of Presentation
  ラフォーレ修善寺　静岡県
- Data Source
  KAKENHI-PROJECT-23510234
[Presentation] MRG-1 acts as an epigenome interpreter of Lys36 methylation on histone H32013
- Author(s)
  Teruaki Takasaki, Thea Egelhofer, Andreas Rechtsteiner, Hiroshi Sakamoto, Susan Strome
- Organizer
  The 19th International C.elegans Meeting
- Place of Presentation
  カリフォルニア大学ロサンゼルス校（アメリカ合衆国）
- Data Source
  KAKENHI-PROJECT-23510234
[Presentation] 線虫C.elegansにおける生殖細胞形成に関与するクロマチンリモデリング因子群の局在機構の解析2013
- Author(s)
  巳波孝至、高崎輝恒、井上邦夫、坂本博
- Organizer
  RNAフロンティアミーティング2013
- Place of Presentation
  ラフォーレ修善寺　静岡県
- Data Source
  KAKENHI-PROJECT-23510234
[Presentation] EJC core subunits have a novel gatekeeper function in mRNA quality control in the nematode C. elegans2012
- Author(s)
  Masami Shiimori, Kunio Inoue & Hiroshi Sakamoto
- Organizer
  The 22th CDB Meeting - RNA Sciences in Cell and Developmental Biology II
- Place of Presentation
  理研神戸CDB
- Data Source
  KAKENHI-PROJECT-23510234
[Presentation] 線虫EJC中核因子Y１４はスプライシング未完了RNAの核外輸送を防ぐ2012
- Author(s)
  椎森仁美、井上邦夫、坂本博
- Organizer
  第14回日本RNA学会年会
- Place of Presentation
  東北大学百周年記念会館、仙台市
- Data Source
  KAKENHI-PROJECT-23510234
[Presentation] EJC core subunits have a novel gatekeeper function in mRNA quality control in the nematode C. elegans2012
- Author(s)
  Masami Shiimori, Kunio Inoue, Hiroshi Sakamoto
- Organizer
  The 22th CDB Meeting - RNA Sciences in Cell and Developmental Biology II
- Place of Presentation
  理化学研究所CDB、神戸市
- Data Source
  KAKENHI-PROJECT-23510234
[Presentation] 線虫 EJC 中核因子 Y14はスプライシング未完了 RNA の核外輸送を防ぐ2012
- Author(s)
  椎森仁美、井上邦夫、坂本博
- Organizer
  第14回日本 RNA 学会年会
- Data Source
  KAKENHI-PROJECT-23510234
[Presentation] Two EJC core subunits, Y14 and MAG-1, have a novel gatekeeper function in mRNA quality control in the nematode C. elegans2011
- Author(s)
  Masami Shiimori, Shunichi Wakabayashi, Yutaka Suzuki, Kenta Nakai, Kunio Inoue & Hiroshi Sakamoto
- Organizer
  The16th annual Meeting of the RNA Society
- Place of Presentation
  京都国際会館
- Data Source
  KAKENHI-PROJECT-23510234
[Presentation] 線虫 Y14はイントロンを含む未スプライシング RNA の核外輸送を防ぐ2011
- Author(s)
  椎森仁美、井上邦夫、坂本博
- Organizer
  RNA フロンティアミーティング2011
- Place of Presentation
  あいち健康プラザ
- Data Source
  KAKENHI-PROJECT-23510234
[Presentation] 線虫Y14はイントロンを含む未スプライシングRNAの核外漏出を防ぐ2011
- Author(s)
  坂本博
- Organizer
  第84回日本生化学会大会(招待講演)
- Place of Presentation
  京都国際会館
- Data Source
  KAKENHI-PROJECT-23510234
[Presentation] AML1 Runt domainに結合するRNAアプタマーの立体構造にもとづく相互作用モデル。2007
- Author(s)
  飯渕宏昭, 野村祐介, 冨士原和也, 千葉学, 田中卓, 田中陽一郎, 福永淳一, 神津知子, 中村義一, 河合剛太, 坂本泰一
- Organizer
  BMB2007 (第30回日本分子生物学会年会・第80回日本生化学会大会合同大会)
- Place of Presentation
  横浜
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13051101
[Presentation] AML1 Runt domainに結合するRNAアプタマーの構造解析。2007
- Author(s)
  野村祐介, 冨士原和也, 千葉学, 飯渕宏昭, 田中卓, 田中陽一郎, 福永淳一, 神津知子, 中村義一, 河合剛太, 坂本泰一
- Organizer
  第46回NMR討論会
- Place of Presentation
  札幌
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13051101
[Presentation] Solution structures of two hairpin loops of an RNA aptamer against mammalian initiation factor 4A.2006
- Author(s)
  Sakamoto, T., Oguro, A., Kawai, G., Ohtsu, T., Nakamura, Y.
- Organizer
  International RNA Society meeting
- Place of Presentation
  Seattle
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13051101
[Presentation] Solution structures of two hairpin loops of an RNA aptamer against mammalian initiation factor 4A.2006
- Author(s)
  Sakamoto, T., Oguro, A., Kawai, G., Ohtsu, T., Nakamura, Y.
- Organizer
  第45回NMR検討会
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13051101
[Presentation] 翻訳開始因子eIF4Aに結合するアプタマーの2つのヘアピン構造2004
- Author(s)
  坂本泰一, 小黒明広, 河合剛太, Nahum Sonenberg, 大津敬, 中村義一
- Organizer
  第6回RNAミーティング(日本RNA学会年会)
- Place of Presentation
  熊本
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13051101
[Presentation] 線虫C.elegansにおけるクロモドメイン蛋白質MRG-1の始原生殖細胞への限局メカニズムの解析
- Author(s)
  巳波孝至、井上邦夫、坂本博、高崎輝恒
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  パシフィコ横浜、横浜市
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-26290062
[Presentation] 線虫C.elegansにおけるRNAの輸送経路を決めるメカニズムの解析
- Author(s)
  相澤理丞、井上邦夫、坂本博
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  パシフィコ横浜、横浜市
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-26290062

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73. 志田壽利 (00144395)

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# of Collaborated Products: 0 results
74. 野本明男 (70112670)

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75. 谷口維紹 (50133616)

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76. 堀田凱 (30010036)

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# of Collaborated Products: 0 results
77. 渡辺嘉典 (20212326)

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78. FUKUMOTO Shoichi

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# of Collaborated Products: 0 results
79. AIZAWA Risuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
80. MIWA Takashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
81. DOBASHI Takumi

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# of Collaborated Products: 0 results
82. マリセン B.

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# of Collaborated Products: 0 results
83. バーリング R.

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84. マティス D.

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# of Collaborated Products: 0 results
85. ベノワ C.

# of Collaborated Projects: 1 results

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86. クーパー J.A.

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87. ハーガン I.M.

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88. ラジャウスキー K.

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89. シラー F.W.

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90. デュマ C.

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91. ツジイ F.I.

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92. ロバーツ G.C.K.

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93. デルセニー M.

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94. フォルセン K.S.

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95. TSUJI Federick

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96. FORSEN Karl

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97. COOPER Jonathan

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# of Collaborated Products: 0 results
98. HAGAN Iain

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# of Collaborated Products: 0 results
99. ROBERTS Gordon

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100. NAKASEKO Nobuyuki

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101. DUMAS C.

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# of Collaborated Products: 0 results
102. SCHELLER Frieder

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103. DELSENY Michel

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104. MATHIS Diane

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105. BENOIST Christophe

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# of Collaborated Products: 0 results
106. MALISSEN Bernard

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# of Collaborated Products: 0 results
107. BALLING Rudolf

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# of Collaborated Products: 0 results
108. RAJEWSKY Klaus

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# of Collaborated Products: 0 results
109. 和田雅人

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# of Collaborated Products: 0 results
110. スレイマン C.W.

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# of Collaborated Products: 0 results
111. ラスキー R.

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112. シュミット R.D.

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# of Collaborated Products: 0 results
113. マリッセン B.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
114. 京極好正

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115. 広瀬哲郎

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# of Collaborated Products: 1 results

SAKAMOTO HIROSHI 坂本 博

SAKAMOTO Hiroshi 坂本 博

Research Projects

Research Products

Co-Researchers

Elucidation of the regulatory mechanism of mRNA stability, which is essential for germ cell differentiation and growthPrincipal Investigator

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A novel function of RNA splicing in control of proliferation and differentiation of germ cellsPrincipal Investigator

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Mechanism of the nuclear retention of unspoiled RNAs that ensures proper expression of genomic informationPrincipal Investigator

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Comprehensive identification of abnormally spliced RNAs and elucidation of their significancePrincipal Investigator

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Analysis of the mrg-1 gene function required for differentiation of primordial germ cells in the nematode C.elegansPrincipal Investigator

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Regulative mechanisms of cell proliferation and differentiation by RNA-binding proteinsPrincipal Investigator

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線虫の発生分化過程におけるRNA結合蛋白質機能の網羅的解析Principal Investigator

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Spatiotemporal Network of RNA Information Flow

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RNA結合蛋白質Huの機能特異性を決定するアミノ酸残基の解析Principal Investigator

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線虫の発生分化過程におけるRNA結合蛋白質機能の網羅的解析Principal Investigator

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Functional analysis of Hu proteins that induce neuronal differentiationPrincipal Investigator

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神経特異的HuD蛋白質の細胞内シャトリングシグナルの解析Principal Investigator

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神経特異的RNA結合蛋白質Huによる細胞分化誘導機構の解析Principal Investigator

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SAKAMOTO HIROSHI 坂本博

SAKAMOTO Hiroshi 坂本博