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tanaka keiji  田中 啓二

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TANAKA Keiji  田中 啓二

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Researcher Number 10108871
Other IDs
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Affiliation (Current) 2023: 公益財団法人東京都医学総合研究所, 基礎医科学研究分野, 理事長
2023: 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 理事長
Affiliation (based on the past Project Information) *help 2020 – 2023: 公益財団法人東京都医学総合研究所, 基礎医科学研究分野, 理事長
2019: 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 理事長
2017: 東京都医学総合研究所, 理事長
2012 – 2017: 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 所長
2014: 公益財団法人東京都医学総合研究所, 所長 … More
2014: 公益財団法人東京都医学総合研究所, 研究所, 所長
2013: 東京都医学総合研究所, 所長
2011: 財団法人東京都医学総合研究所, 生体分子先端研究分野, 所長
2010: 東京都臨床医学総合研究所, 所長代行
2009 – 2010: (財)東京都医学総合研究所, 東京都臨床医学総合研究所, 理事
2009: 東京都医学研究機構, 研究員
2009: Tokyo Metropolitan Organization for Medical Research, 東京都臨床医学総合研究所, 参事研究員
2008: Tokyo Metropolitan Organization for Medical Research, 東京都臨床医学総合研究所, 参事研究員
2007: Tokyo Metropolitan Organization for Medical Research, 東京都臨床医学総合研究所, 参事研究員
2005 – 2006: (財)東京都医学研究機構, 東京都臨床医学総合研究所, 参事研究員
2005: 東京都医学研究機構, 研究員
2004: the tokyo metropolitan institute of medical science, the tokyo metropolitan institute of medical science, Acting Director, 東京都臨床医学綜合研究所, 参事研究員
2001 – 2004: 財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 参事研究員
2000 – 2004: 東京都臨床医学総合研究所, 部長
2000: Tokyo Metropolitan Institute of Medical Science, Laboratory Chief, 部長(研究職)
2000: 東京都臨床医学総合研究所, 分子腫瘍学研究部門, 部長(研究職)
1999: 東京都・臨床医学総合研究所, 部長(研究職)
1996 – 1998: 東京都臨床医学総合研究所, 部長
1997: (財)東京都臨床医学総合研究所, 化学療法研究部門, 研究員
1997: The Tokyo Metropolitan Institute of Medical Science, Researcher, 化学療法研究部門, 研究員
1997: Researcher, 化学療法・研究部門, 研究員
1996: 財団法人東京都臨床医学総合研究所, 化学療法研究部門, 研究員
1996: 財団法人東京都臨床医学総合研究所, 科学療法研究部門, 研究員
1994 – 1996: 徳島大学, 酵素科学研究センター, 教授
1995: Tokushima Univ., 酵素科学研究センター, 助教授
1987 – 1994: 徳島大学, 酵素科学研究センター, 助手
1990: 徳島大, 酵素センター, 助手
1989 – 1990: 徳島大学, 酵素センター, 助手
1989: Institute for Enzyme Research, University of Tokushima, Research Assistant, 助手
1986: 徳島大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Biological Sciences / Medium-sized Section 44:Biology at cellular to organismal levels, and related fields / Pathological medical chemistry / General medical chemistry / Structural biochemistry / Functional biochemistry / 物質生物化学
Except Principal Investigator
Biological Sciences / Pathological medical chemistry / Neurology … More / Urology / General medical chemistry / Cell biology / Biophysics / Human pathology / Structural biochemistry Less
Keywords
Principal Investigator
プロテアソーム / ユビキチン / タンパク質分解 / ubiquitin / proteasome / ATP依存性プロテアーゼ / 蛋白質分解 / 抗原プロセシング / PA28 / 脳神経疾患 … More / 蛋白質 / ATP / 神経変性疾患 / オートファジー / 蛋白分解 / 細胞周期 / 多成分複合体 / 品質管理 / TAP / MHC / 液-液相分離 / メンブレンレスオルガネラ / 液滴 / RAD23B / プロテアソーム顆粒 / プロテオーム / 免疫学 / 酵素 / バイオテクノロジー / ユビキチンリガーゼ / 免疫識別 / 抗原提示 / ストレス応答 / 遺伝子破壊 / 一次構造 / プロテアソ-ム / 相分離 / 液ー液相分離 / 液一液相分離 / PROTACs / 遺伝学的解析 / 液―液相分離 / 細胞内タンパク質分解 / Molecular Structure / Multisubunit Complex / Multifunctional Enzyme / Intracellular Protease / 多機能酵素複合体 / 20S粒子 / プロテアーゼ複合体 / 高分子量プロテアーゼ / 造腫瘍性変動 / 遺伝子構造 / 細胞内分布 / 活性調節 / 分子構造 / 巨大分子 / 多機能酵素 / 細胞内プロテアーゼ / neurodegenerative diseases / protein / stress / signal transduction / enzyme / ユビキチン様蛋白質 / NEDD8 / SCF / ストレス / シグナル伝達 / ATP-dependent protease / primary structure / cDNA cloning / proteolysis / structure-function relationship / gene disruption / ATPase / 構造-機能相関 / cDNAクローニング / CDNAクローニング / 構造機能相関 / antigenic peptide / endogenous antigen / antigen presentation / antigen processing / キラーT細胞 / 免疫制御 / 抗原プロセッシング / 抗原エピトープ / 免疫プロテアソーム / インターフェロン-γ / 抗原ペプチド / TAp / 内在性抗原 / バノオテクノロジー / マイトファジー / autophagy / 胸腺特異的プロテアソーム / ガン / 分子多様性 / 分子集合 / CDKキナーゼ / サイクリン / 免疫始動制御 / 細胞周期制御 / 熱ショック蛋白HSP70 / 分子シャペロン / 酵母 / 分子遺伝学 / 細胞増殖 / 多機能プロテア-ゼ / 高分子量プロテア-ゼ / cDNAクロ-ニング / 多機能プロテア-ゼ複合体 … More
Except Principal Investigator
プロテアソーム / 蛋白分解 / ユビキチン / 増殖因子 / オートファジー / プロテアーゼ / 細胞周期 / プロテアソ-ム / 肝細胞 / Proteasome / 増殖抑制因子 / NMR / 初代培養 / Nda1 / MCM / 26S proteasone / Mos / Tom1 / K-252a / RCC1 / Ubiquitin / エネルギー依存性蛋白分解 / 抗原プロセシング / エネルギー依存性蛋白質分解 / 多機能プロテア-ゼ複合体 / インターロイキン / 分化 / 細胞膜調節因子 / 初代培養肝細胞 / TGF-β / リソソーム / X線構造解析 / バイオモジュレーター / カルパイン / プロテオリシス / 肝再生 / 細胞接触 / 蛋白分解酵素 / 細胞増殖因子 / 神経変性疾患 / 脳神経疾患 / 遺伝子 / 生理学 / 細胞・組織 / 蛋白質 / 細胞内分解 / TAT / Parkinson / Mitochondria / Parkinson's disease / DJ-1 / mitochondria / Phorbol ester(TPA) / cAMP / Interleukin-1beta / Transforming growth factor(TGF)-beta / Cell contact / Primary culture / Growth factors / Hepatocytes / 組織構築 / 細胞分化 / 増殖と機能 / 肝細胞培養 / 肝組織 / 混合培養 / 細胞膜 / DNA合成 / 細胞間相互作用 / 増殖 / ホルボ-ルエステル / cyclic AMP / Interleukin(IL-1) / Transfoming Growth Factor(TGF-beta) / ホルボル・エステル(TPA) / CAMP / Interleukin-1β / Transforming growth factor(TGF)-β / Ornithine Decarboxylase / Calpain / Proteases / Protein Degradation / Proteolysis / トリプターゼ / X線解析 / オルニチン脱炭酸酵素 / Immuno-response / Crystal Structure / 細胞内蛋白分解 / X線結晶解析 / 免疫応答 / X線結晶構造解析 / ACTIVATING FACTOR / INTERFERON-gamma / ANTIGEN PRESENTATION / ANTIGEN PROSECCING / PROTEASOME / MHCクラスI / プロテアソーム活性化因子 / γ型インターフェロン / 活性化因子 / インターフェロンγ / 抗原提示 / immunohistochemistry / cell degeneation / ubiquitin / inhibitor / protease / aging / Alzheimer's disease / 免疫組織化学 / 細胞変性 / インヒビター / 老化 / アルツハイマー病 / yeast mutant pre1-1 / reticulocyte lysate / 26S proteasomes / energy-dependent proteolysis / mutant protein / primary hyperoxaluria type 1 / alanine : glyoxylate aminotransferase / serine : pyruvate aminotransferase / ユビキチン系 / 蓚酸 / 酵母変異株prel-1 / エネルギー症候性蛋白質分解 / 酵母変異株pre1-1 / 網状赤血球溶血液 / 26Sプロテアソーム / 変異蛋白質 / 原発性高蓚酸尿症1型 / アラニン:グリオキシル酸トランスアミナーゼ / セリン:ピルビン酸トランスアミナーゼ / Cyclin A / G2ブロック / MPF / PCC / セントロメア / サイクリン / G2 / CDC2 / 染色体 / cdc28 / TOMI / MOS / ライセンス因子 / CyclinA / Biosensor / Protein interaction / Gene targeting / Higher plants / Morphogenesis / Cre-loxP / Fission yeast / 植物 / 胚形成 / 蛋白高次機能構造 / 遺伝子ターゲティング / RNAプロセシング / バイオモニタリング / DNA再複製 / 温度感受性突然変異体 / ATPase / 免疫病 / 免疫系 / バイオセンサー / 分子相互作用 / 遺伝子標的 / 高等植物 / 形態形成 / Cre-IoxP / 分裂酵母 / MHC classI-restricted antigen presentation / Gamma-interferon / Supramolecular complex / Antigen Processing / Cell cycle / Energy-dependent proteolysis / 細胞増殖・分化 / エネルギ-依存性分子識別 / 蛋白質超分子複合体 / エネルギー依存性分子識別 / 分子適合 / 抗原プロセシング・提示 / 細胞内蛋白質分解機構 / 遺伝子転写制御機構 / 多機能プロテアーゼ複合体 / MHCクラスI拘束性抗原提示 / MHCクラスエ拘束性抗原提示 / ガンマ型インターフェロン / 超分子複合体 / High molecular weight protease / Multisubunit complex / Structural analysis / Multicatalytic protease / Proteasomes / 発生と分化 / cDNAクロ-ニング / 20S環状粒子 / 細胞内プロテア-ゼ / 分子遺伝学 / 高分子量プロテア-ゼ / 構造解析 / 多成分複合体 / 多機能プロテア-ゼ / 肝癌細胞 / 血小板 / 細胞増殖調節 / 前癌状態 / 過形成腫粒 / 肝細胞の増殖と分化 / 自己免疫病 / HLA立体構造 / ゲノム / 疾病 / HLA / データベース / 疾病感受性 / 進化 / 自己免疫疾患 / 移植 / 疾患抵抗性 / 疾患感受性 / 立体構造 / ゲノム多様性 / ＨＬＡ / シグナル伝達 / 複合体 / 電子顕微鏡 / X線結晶学 / 相互作用 / タンパク質 / 生物物理学 / 分子生物学 / 細胞生物学 / 生化学 / 構造生物学 / ミトファジー / パーキンソン病 / calcitonin-related polypeptide(CGRP1) / calcitonin / calcitonin/calcitonin-related polypeptide(CGRP1) / セロトニン受容体アゴニスト / 転写障害 / ユビチキン / ポリグルタミン / )球脊髄性筋萎縮症 / 分子シャペロン / ユビキチン-プロテアゾーム系 / 運動ニューロン / JNK / 神経変性 / 球脊髄性筋萎縮症 / ポリグルタミン病 / ホームページ / 基質蛋白質の選別 / モディファイアー蛋白質 / モディファイアー蛋白 / 蛋白質分解 / 免疫プロテアソーム / 蛋白質の寿命 / 蛋白質分解酵素 / オルニチン脱炭素酵素 / バイオモジュレータ / 遺伝子発現 / 腎細胞癌 / 肝臓機能 / 遺伝子破壊 / 癌胎児性蛋白 / 生物工学 / 遺伝子操作 / ツメガエル卵の発現系 / 肝細胞の初代培養 / 卵母細胞 / マイクロインジェクション / ヒト単球 / 細胞工学 / 発現ベクタ- / 増殖制御因子 / 蛋白復合体 / 白血病細胞 / 異常発現 / 細胞増殖 / がん細胞 / 多機能プロテアーゼ / Tーキニノーゲン / processing / 発情勃起 / 神経腫瘍 / 経胎盤投与 / エチルニトロソ尿素 / 無アルブミンラット Less

  • Research Projects

    (44 results)

  • Research Products

    (599 results)

  • Co-Researchers

    (237 People)

  •  プロテアソーム：相分離とユビキチンが拓く生理病態学Principal Investigator

    • Principal Investigator
      田中 啓二
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 44:Biology at cellular to organismal levels, and related fields
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science

  •  Cell Biology of ProteasomesPrincipal Investigator

    • Principal Investigator
      TANAKA Keiji
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 44:Biology at cellular to organismal levels, and related fields
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science

  •  リン酸化ユビキチンを手がかりにマイトファジーの全貌にせまるHost Researcher

    • Host Researcher
      田中 啓二
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for JSPS Fellows
    • Research Field
      Cell biology
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science

  •  The Proteasome: Mechanistic Actions and In-depth Physiopathological AnalysesPrincipal Investigator

    • Principal Investigator
      TANAKA Keiji
    • Project Period (FY)
      2014 – 2019
    • Research Category
      Grant-in-Aid for Specially Promoted Research
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science

  •  Multidisciplinary research on autophagy: from molecular mechanisms to disease states

    • Principal Investigator
      Mizushima Noboru
    • Project Period (FY)
      2013 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo

  •  Structural basis of cell-signaling complexes mediating signal perception, transduction and responses.

    • Principal Investigator
      HAKOSHIMA Toshio
    • Project Period (FY)
      2010 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Nara Institute of Science and Technology

  •  Integrated redearch for HLA disease and evolution

    • Principal Investigator
      SASAZUKI Takehiko
    • Project Period (FY)
      2010 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Kyushu University

  •  In-depth Analysis of Proteasome-Mediated Regulatory ProteolysisPrincipal Investigator

    • Principal Investigator
      TANAKA Keiji
    • Project Period (FY)
      2009 – 2013
    • Research Category
      Grant-in-Aid for Specially Promoted Research
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science

  •  Development of Molecular Targeted Disease Modifying Therapy for Polyglutamine Diseases

    • Principal Investigator
      SOBUE Gen
    • Project Period (FY)
      2009 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Neurology
    • Research Institution
      Nagoya University

  •  Effects of mitophagy on cell death in Parkinson's disease model cells

    • Principal Investigator
      SAIKI Shinji
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Neurology
    • Research Institution
      Juntendo University

  •  Analyses of Molecular Assembly and Diversity of ProteasomesPrincipal Investigator

    • Principal Investigator
      TANAKA Keiji
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Specially Promoted Research
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research

  •  Studies on proteolysis mediated by the proteasomes and ubiquitinPrincipal Investigator

    • Principal Investigator
      TANAKA Keiji
    • Project Period (FY)
      2001 – 2005
    • Research Category
      Grant-in-Aid for Specially Promoted Research
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research

  •  蛋白質分解-新しいモディフアイアー蛋白質による制御

    • Principal Investigator
      木南 英紀
    • Project Period (FY)
      2000 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Juntendo University

  •  プロテアソームによる細胞周期と免疫始動制御Principal Investigator

    • Principal Investigator
      田中 啓二
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research

  •  蛋白分解のニューバイオロジー

    • Principal Investigator
      鈴木 紘一
    • Project Period (FY)
      1996 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Tokyo Metropolitan Institute of Gerontology
      The University of Tokyo

  •  プロテアソームの分子様態・結晶構造と機能解析に関する研究

    • Principal Investigator
      MORIMOTO Yukio
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Himeji Institute of Technology

  •  Mechanism of Selective Degradation of Proteins

    • Principal Investigator
      SUZUKI Koichi
    • Project Period (FY)
      1996 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Metropolitan Institute of Gerontology
      The University of Tokyo

  •  プロテアソームによる細胞周期の制御Principal Investigator

    • Principal Investigator
      田中 啓二
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokushima

  •  バイオモジュレーターとしてのプロテアーゼ

    • Principal Investigator
      SUZUKI Koichi
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Field
      Structural biochemistry
    • Research Institution
      The University of Tokyo

  •  プロテアソームの分子構造と細胞生物学的機能解析Principal Investigator

    • Principal Investigator
      田中 啓二
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Functional biochemistry
    • Research Institution
      The University of Tokushima

  •  Development of the reconstituted antigen presenting system and its medical applicationPrincipal Investigator

    • Principal Investigator
      TANAKA Keiji
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      The Tokyo Metropolitan Institute of Medical Science
      The University of Tokushima

  •  Crystal Structure Analysis of Bovine 20S Proteasome at High Resolution.

    • Principal Investigator
      MORIMOTO Yukio
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biophysics
    • Research Institution
      Himeji Institute of Technology
      The University of Tokushima

  •  Structural and genetic analysis of proteasomesPrincipal Investigator

    • Principal Investigator
      TANAKA Keiji
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Structural biochemistry
    • Research Institution
      The Tokyo Metropolitan Institute of Medical Science

  •  蛋白質分解システムとストレス応答Principal Investigator

    • Principal Investigator
      田中 啓二
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokushima

  •  Intracellular Degradation of a Mutant Serine : Pyruvate/Alanine : Glyoxylate Aminotransferase

    • Principal Investigator
      ICHIYAMA Arata
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Hamamatsu University School of Medicine

  •  Abnormal Expressions of Proteases and Inhibitors in the brains of Alzheimer's disease and aging.

    • Principal Investigator
      II Kunio
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Human pathology
    • Research Institution
      The University of Tokushima

  •  RESEARCH FOR THE MHC CLASS I RESTRICTED ANTIGEN PROCESSING AND PRESENTATION

    • Principal Investigator
      AKIYAMA Kinya, 安芸 雅史
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Urology
    • Research Institution
      THE UNIVERSITY OF TOKUSHIMA

  •  Regulation of Gene Expression

    • Principal Investigator
      TANIGUCHI Masaru
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Chiba University

  •  Regulation of MPF activation and Institute of Mitosis

    • Principal Investigator
      NISHIMOTO Takeharu
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyushu University

  •  Studies on structure and the biological functions of a large multi-molecular complex "the proteasome"

    • Principal Investigator
      ICHIHARA Akira
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for Specially Promoted Research
    • Research Institution
      Institute for Enzyme Research, The University of Tokushima

  •  プロテアソ-ム(巨大蛋白分解酵素復合体)の構造解析と癌化における発現異常の解明

    • Principal Investigator
      市原 明
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The University of Tokushima

  •  培養肝細胞を用いた機能と増殖を調節する肝組織構築の生化学的研究

    • Principal Investigator
      市原 明
    • Project Period (FY)
      1990 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      The University of Tokushima

  •  尿路性器癌におけるプロテアソ-ムの異常発現機構に関する研究

    • Principal Investigator
      香川 征
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Urology
    • Research Institution
      The University of Tokushima

  •  遺伝子破壊法による酵母プロテアソ-ム(巨大蛋白分解酵素複合体)の機能解析Principal Investigator

    • Principal Investigator
      田中 啓二
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      物質生物化学
    • Research Institution
      The University of Tokushima

  •  無アルブミンラットによる癌研究

    • Principal Investigator
      長瀬 すみ
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Sasaki Institute

  •  多機能プロテアーゼ復合体(プロテアソーム)の機能と癌化における異常発現機構の解析

    • Principal Investigator
      ICHIHARA Akira
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The University of Tokushima

  •  真核生物に遍在するプロテアソ-ム(多成分プロテア-ゼ復合体)の遺伝子構造解析Principal Investigator

    • Principal Investigator
      田中 啓二
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      The University of Tokushima

  •  肝細胞増殖制御因子の生物工学的技法による同定,遺伝子構造解析と大量生産のシステム化

    • Principal Investigator
      市原 明
    • Project Period (FY)
      1989 – 1991
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      General medical chemistry
    • Research Institution
      The University of Tokushima

  •  Structure and Cell Biology of a Novel Multicatalytic Proteinase Complex

    • Principal Investigator
      ICHIHARA Akira
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      General medical chemistry
    • Research Institution
      The University of Tokushima

  •  培養肝細胞を用いた増殖と分化の制御機構の研究

    • Principal Investigator
      市原 明
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The University of Tokushima

  •  培養肝細胞を用いた増殖と分化の制御機構の研究

    • Principal Investigator
      市原 明
    • Project Period (FY)
      1987
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The University of Tokushima

  •  Molecular Structure and Functional Propeerties of a High Molecular Weight-Multiprotease ComplexPrincipal Investigator

    • Principal Investigator
      TANAKA Keiji
    • Project Period (FY)
      1987 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      The University of Tokushima

  •  培養肝細胞を用いた増殖と分化の制御機構の研究

    • Principal Investigator
      市原 明
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The University of Tokushima

  •  Biochemical studies on tissue architecture of liver, which controls functions and growth, using primary cultured hepatocytes

    • Principal Investigator
      ICHIHARA Akira
    • Project Period (FY)
      1986 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      University of Tokushima

All 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 Other

All Journal Article Presentation Book Patent

  • [Book] 実験医学2020
    • Author(s)
      田中啓二、若槻壮市
    • Total Pages
      240
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-19H00997

  • [Book] 「構造生命科学からトランススケール・イメージングによる細胞動態学へ」実験医学増刊号2020
    • Author(s)
      田中啓二、若槻壮市(編集)
    • Total Pages
      240
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Book] Medical Science Digest2019
    • Author(s)
      田中啓二
    • Total Pages
      35
    • Publisher
      ニューサイエンス社
    • Data Source
      KAKENHI-PROJECT-19H00997

  • [Book] Ubiquitin chain elongation : An intriguing strategy. Mol Cell (preview)2014
    • Author(s)
      Iwai, K. and Tanaka, K.
    • Total Pages
      3
    • Publisher
      Cell Press
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Book] プログレッシブ 生命科学　（第一版）2014
    • Author(s)
      吉森 保、岡正啓、米田悦啓、田中亀代次、西條將文、岩井一宏、菊池章、松本真司、岡村康司、 山本浩靖、木原進士、松岡達、高木都、犬束歩、山中章弘、金井好克、磯谷綾子、伊川正人 古川貴久、戸田達史、他
    • Total Pages
      312
    • Publisher
      南山堂
    • Data Source
      KAKENHI-ORGANIZER-25111001

  • [Book] FROM EAST TO WEST : Pioneers in Parkinson's disease in Japan-A historical overview of major achievement in research2014
    • Author(s)
      Tanaka, K.
    • Total Pages
      2
    • Publisher
      QOL laboratory Corp
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Book] Keio J.Med.2012
    • Author(s)
      Tanaka, K.
    • Publisher
      慶應義塾大学(in press)
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Book] Brain and Nerve2012
    • Author(s)
      松田憲之, 田中啓二, 小松雅明
    • Total Pages
      6
    • Publisher
      医学書院
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Book] Curr.Opini.Immunol2012
    • Author(s)
      Takahama, Y., Takada, K., Murata, S., Tanaka, K.
    • Total Pages
      7
    • Publisher
      Elsevier Ltd.
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Book] 「アレルギー」(社)日本アレルギー学会編2012
    • Author(s)
      田中啓二
    • Publisher
      (社)日本アレルギー学会(印刷中)
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Book] Annual Review 2012神経2012
    • Author(s)
      田中啓二, 松田憲之, 尾勝圭
    • Total Pages
      6
    • Publisher
      中外医学社
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Book] 化学と生物(日本農芸化学会学会誌)2011
    • Author(s)
      松田憲之, 田中啓二
    • Total Pages
      7
    • Publisher
      日本農芸化学会
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Book] 実験医学2011
    • Author(s)
      松田憲之, 尾勝圭, 田中啓二
    • Total Pages
      7
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Book] Assembly and function of the proteasome. "Ubiquitin Family Modifiers and the Proteasome : Reviews and Protocols"2011
    • Author(s)
      Saeki, Y, Tanaka, K.
    • Publisher
      Humana Press. SPRINGER SCIENCE+BUSINESS MEDIA, New York, (USA)(In press)
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Book] Surgery Frontier 2011年6月号特集2011
    • Author(s)
      田中啓二
    • Total Pages
      6
    • Publisher
      メジカルビュー社
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Book] 病理と臨床2011
    • Author(s)
      田中啓二
    • Total Pages
      5
    • Publisher
      文光堂
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Book] ライフサイエンス「新着論文レビュー」2011
    • Author(s)
      佐伯泰、田中啓二
    • Publisher
      大学共同利用機関法人情報・システム研究機構ライフサイエンス統合データベースセンター
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Book] 実験医学2011年7月増刊2011
    • Author(s)
      田中啓二
    • Total Pages
      8
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Book] 日本栄養・食糧学会誌2011
    • Author(s)
      田中啓二
    • Total Pages
      8
    • Publisher
      公益社団法人日本栄養・食糧学会(総説)
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Book] Methods in Molecular Biology2011
    • Author(s)
      Saeki, Y, Tanaka, K.
    • Total Pages
      23
    • Publisher
      Humana Press. New York (USA)
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Book] Bio Clinica2011
    • Author(s)
      松田憲之, 田中啓二
    • Total Pages
      5
    • Publisher
      北隆館
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Book] 神経内科2011
    • Author(s)
      井口正寛, 松田憲之, 田中啓二
    • Total Pages
      7
    • Publisher
      科学評論社
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Book] ユビキチンとプロテアソーム : 炎症・再生医学辞典2009
    • Author(s)
      田中啓二
    • Publisher
      朝倉書店(印刷中)
    • Data Source
      KAKENHI-PROJECT-17002019

  • [Book] ユビキチン・プロテアソーム・オートファジー : 免疫の事典2009
    • Author(s)
      田中啓二
    • Publisher
      朝倉書店(印刷中)
    • Data Source
      KAKENHI-PROJECT-17002019

  • [Book] 蛋白質の寿命 : 蛋白質の事典2009
    • Author(s)
      田中啓二
    • Publisher
      朝倉書店(印刷中)
    • Data Source
      KAKENHI-PROJECT-17002019

  • [Book] 巨大で複雑な蛋白質分解装置の動態と作動機構「構造プロテオミクスの新時代 : 医薬の分子設計と構造生物学の融合」蛋白質核酸酵素 増刊号2009
    • Author(s)
      水島恒裕・田中啓二
    • Publisher
      共立出版(印刷中)
    • Data Source
      KAKENHI-PROJECT-17002019

  • [Book] 「分子細胞生物学辞典」:免疫プロテアソーム・ハイブリッドプロテアソーム2008
    • Author(s)
      田中啓二
    • Publisher
      東京化学同人
    • Data Source
      KAKENHI-PROJECT-17002019

  • [Book] ユビキチン-プロテアソーム系「細胞の蛋白質品質管理機構と心血管疾患」血管医学2008
    • Author(s)
      田中啓二
    • Total Pages
      4
    • Publisher
      メディカルレビュー社
    • Data Source
      KAKENHI-PROJECT-17002019

  • [Book] 「分子細胞生物学辞典」 : 免疫プロテアソーム・ハイブリッドプロテアソーム2008
    • Author(s)
      田中啓二(分担)
    • Total Pages
      2
    • Publisher
      東京化学同人
    • Data Source
      KAKENHI-PROJECT-17002019

  • [Book] ユビキチンと神経変性 : 臨床神経科学(Clinical Neuroscience)2008
    • Author(s)
      田中啓二
    • Total Pages
      2
    • Publisher
      中外医薬社
    • Data Source
      KAKENHI-PROJECT-17002019

  • [Book] プロテアソームの新しいユビキチンレセプター. 細胞工学2008
    • Author(s)
      佐伯泰、田中啓二
    • Publisher
      学研メディカル秀潤社
    • Data Source
      KAKENHI-PROJECT-17002019

  • [Book] プロテアソームの新しいユビキチンレセプター.細胞工学2008
    • Author(s)
      佐伯泰、田中啓二
    • Total Pages
      2
    • Publisher
      秀潤社
    • Data Source
      KAKENHI-PROJECT-17002019

  • [Book] プロテアソーム:キーワード:蛋白質の一生「蛋白質核酸酵素」増刊号2008
    • Author(s)
      田中啓二
    • Publisher
      共立出版
    • Data Source
      KAKENHI-PROJECT-17002019

  • [Book] ユビキチンと神経変性:臨床神経科学(Clinical Neuroscience)2008
    • Author(s)
      田中啓二
    • Publisher
      中外医学社
    • Data Source
      KAKENHI-PROJECT-17002019

  • [Book] プロテアソーム : キーワード : 蛋白質の一生.蛋白質核酸酵素」増刊号2008
    • Author(s)
      田中啓二
    • Total Pages
      7
    • Publisher
      共立出版
    • Data Source
      KAKENHI-PROJECT-17002019

  • [Book] 蛋白質の寿命:蛋白質の事典2008
    • Author(s)
      田中啓二
    • Publisher
      朝倉書店
    • Data Source
      KAKENHI-PROJECT-17002019

  • [Book] Ubiquity and diversity of the proteasome system. In " Protein Degradation"(Eds. By Mayer, R. J., Ciechanover, A., and Rechsteiner, M.)2006
    • Author(s)
      Tanaka, K., Yashiroda, H., Murata, S.
    • Publisher
      Wiley-VCH Verlag GmbH, Weinheim, Germany
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13002008

  • [Book] Ubiquity and diversity of the proteasome system. In " Protein Degradation" (Eds. By Mayer, R. J., Ciechanover, A., and Rechsteiner, M.)2006
    • Author(s)
      Tanaka, K., Yashiroda, H., Murata, S.
    • Publisher
      Wiley-VCH Verlag GmbH, Weinheim, Germany
    • Data Source
      KAKENHI-PROJECT-17002019

  • [Book] Ubiquity and diversity of the proteasome system. In "Protein Degradation"(Eds. By Mayer, R.J., Ciechanover, A., and Rechsteiner, M.)2006
    • Author(s)
      Tanaka, K.
    • Publisher
      Wiley-VCH Verlag GmbH, Weinheim, Germany in press
    • Data Source
      KAKENHI-PROJECT-17002019

  • [Book] Methods in Enzymology : Large- and small-scale purification of mammalian 26S proteasomes.2005
    • Author(s)
      Hirano, Y., Murata, S., Tanaka, K.
    • Publisher
      Academic Press, New York(in press)
    • Data Source
      KAKENHI-PROJECT-13002008

  • [Book] Preparation of proteasomes. in "Cell Biology : A Laboratory Handbook" (Ed. by J.E.Celis) 3rd edition.2005
    • Author(s)
      Tanaka, K.
    • Publisher
      Academic Press, New York
    • Data Source
      KAKENHI-PROJECT-17002019

  • [Book] 巨大で複雑な蛋白質分解装置の動態と作動機構「構造プロテオミクスの新時代:医薬の分子設計と構造生物学の融合」蛋白質核酸酵素増刊号
    • Author(s)
      水島恒裕・田中啓二
    • Publisher
      共立出版
    • Data Source
      KAKENHI-PROJECT-17002019

  • [Book] ユビキチン・プロテアソーム・オートファジー:免疫の事典
    • Author(s)
      田中啓二
    • Publisher
      朝倉書店(印刷中)
    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] The effect of nutrient deprivation on proteasome activity in 4-week-old mice and 24-week-old mice2022
    • Author(s)
      Nobuyuki Tanahashi, Moeko Komiyama, Mina Tanaka, Yuta Yokobori Shigeo Murata, and Keiji Tanaka
    • Journal Title

      Journal of Nutritional Biochemistry

      Volume: 0 Pages: 0-0

    • DOI

      10.1016/j.jnutbio.2022.108993

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K11658, KAKENHI-PLANNED-18H05500, KAKENHI-PROJECT-18H04022, KAKENHI-PROJECT-19H00997

  • [Journal Article] Unfolding is the driving force for mitochondrial import and degradation of the Parkinson's disease-related protein DJ-12021
    • Author(s)
      Queliconi BB, Kojima W, Kimura M, Imai K, Udagawa C, Motono C, Hirokawa T, Tashiro S, Caaveiro JMM, Tsumoto K, Yamano K, Tanaka K, Matsuda N
    • Journal Title

      J Cell Sci

      Volume: 134 Issue: 22 Pages: 1-1

    • DOI

      10.1242/jcs.258653

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K11543, KAKENHI-PROJECT-18H02443, KAKENHI-PLANNED-18H05500, KAKENHI-PLANNED-19H05712, KAKENHI-PROJECT-19H00997

  • [Journal Article] Loss of peptide: N -glycanase causes proteasome dysfunction mediated by a sugar-recognizing ubiquitin ligase2021
    • Author(s)
      Yoshida Yukiko、Asahina Makoto、Murakami Arisa、Kawawaki Junko、Yoshida Meari、Fujinawa Reiko、Iwai Kazuhiro、Tozawa Ryuichi、Matsuda Noriyuki、Tanaka Keiji、Suzuki Tadashi
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 118 Issue: 27

    • DOI

      10.1073/pnas.2102902118

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02443, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05499, KAKENHI-PLANNED-19H05712, KAKENHI-PROJECT-17H06174, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-19H02926

  • [Journal Article] TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains2021
    • Author(s)
      Kaiho-Soma Ai、Akizuki Yoshino、Igarashi Katsuhide、Endo Akinori、Shoda Takuji、Kawase Yasuko、Demizu Yosuke、Naito Mikihiko、Saeki Yasushi、Tanaka Keiji、Ohtake Fumiaki
    • Journal Title

      Molecular Cell

      Volume: 81 Issue: 7 Pages: 1411-1424.e7

    • DOI

      10.1016/j.molcel.2021.01.023

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07009, KAKENHI-PROJECT-17H01882, KAKENHI-PLANNED-18H05498, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-20K22726, KAKENHI-PROJECT-17H03986, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-21H03604, KAKENHI-PROJECT-21K05320

  • [Journal Article] Mammalian BCAS3 and C16orf70 associate with the autophagosome formation site in response to selective and non-selective autophagy2021
    • Author(s)
      Kojima, K., Yamano, K., Kosako, H., Imai, K., Kikuchi, R., Tanaka, K., and Matsuda, M.
    • Journal Title

      Autophagy

      Volume: 17 Pages: 2011-2036

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H00997

  • [Journal Article] Critical role of mitochondrial ubiquitination and the OPTN?ATG9A axis in mitophagy2020
    • Author(s)
      Yamano Koji、Kikuchi Reika、Kojima Waka、Hayashida Ryota、Koyano Fumika、Kawawaki Junko、Shoda Takuji、Demizu Yosuke、Naito Mikihiko、Tanaka Keiji、Matsuda Noriyuki
    • Journal Title

      Journal of Cell Biology

      Volume: 219 Issue: 9 Pages: 1-23

    • DOI

      10.1083/jcb.201912144

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-19K07009, KAKENHI-PLANNED-18H05500, KAKENHI-PLANNED-18H05502, KAKENHI-PLANNED-19H05712, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-18K06237

  • [Journal Article] Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses.2020
    • Author(s)
      Oikawa D, Sato Y, Ohtake F, Komakura K, Hanada K, Sugawara K, Terawaki S, Mizukami Y, Phuong HT, Iio K, Obika S, Fukushi M, Irie T, Tsuruta D, Sakamoto S, Tanaka K, Saeki Y, Fukai S, Tokunaga F.
    • Journal Title

      Commun. Biol.

      Volume: 3 Issue: 1 Pages: 163-163

    • DOI

      10.1038/s42003-020-0882-8

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K22541, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-ORGANIZER-16H06429, KAKENHI-PLANNED-18H05501, KAKENHI-PROJECT-18H02619, KAKENHI-PROJECT-17K19560, KAKENHI-PROJECT-19K22968, KAKENHI-PLANNED-16H06575, KAKENHI-PUBLICLY-19H04837, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-18K06937, KAKENHI-PLANNED-18H05498, KAKENHI-PROJECT-16H06276

  • [Journal Article] Ribosomal protein S7 ubiquitination during ER stress in yeast is associated with selective mRNA translation and stress outcome2020
    • Author(s)
      Matsuki Yasuko、Matsuo Yoshitaka、Nakano Yu、Iwasaki Shintaro、Yoko Hideyuki、Udagawa Tsuyoshi、Li Sihan、Saeki Yasushi、Yoshihisa Tohru、Tanaka Keiji、Ingolia Nicholas T.、Inada Toshifumi
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 19669-19669

    • DOI

      10.1038/s41598-020-76239-3

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06481, KAKENHI-PROJECT-20K06490, KAKENHI-PUBLICLY-19H05281, KAKENHI-PROJECT-18H03977, KAKENHI-PROJECT-19H00997, KAKENHI-PLANNED-18H05498, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-17H04998

  • [Journal Article] Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation2020
    • Author(s)
      A. Nishiyama, C. Mulholland, S. Bultmann, S. Kori, A. Endo, Y. Saeki, W. Qin, C. Trummer, Y. Chiba, H. Yokoyama, S. Kumamoto, T. Kawakami, H. Hojo, G. Nagae, H. Aburatani, K. Tanaka, K. Arita, H. Leonhardt, M. Nakanishi
    • Journal Title

      Nat. Commun.

      Volume: 11 Issue: 1 Pages: 1222-1222

    • DOI

      10.1038/s41467-020-15006-4

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K05316, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05498, KAKENHI-PUBLICLY-19H05285, KAKENHI-PLANNED-19H05744, KAKENHI-PROJECT-18H03993, KAKENHI-PROJECT-18H02392, KAKENHI-PROJECT-19H03153, KAKENHI-PROJECT-19J22030, KAKENHI-PLANNED-19H05740, KAKENHI-PROJECT-17H01398, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-18K07963, KAKENHI-ORGANIZER-19H05739

  • [Journal Article] The HOIL-1L ligase modulates immune signalling and cell death via monoubiquitination of LUBAC2020
    • Author(s)
      Fuseya Yasuhiro、Fujita Hiroaki、Kim Minsoo、Ohtake Fumiaki、Nishide Akira、Sasaki Katsuhiro、Saeki Yasushi、Tanaka Keiji、Takahashi Ryosuke、Iwai Kazuhiro
    • Journal Title

      Nature Cell Biology

      Volume: － Issue: 6 Pages: 663-673

    • DOI

      10.1038/s41556-020-0517-9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-ORGANIZER-18H05497, KAKENHI-PROJECT-20K16144, KAKENHI-PLANNED-18H05499, KAKENHI-PROJECT-17H06174, KAKENHI-PROJECT-19H00997, KAKENHI-PLANNED-18H05498, KAKENHI-PUBLICLY-20H05319, KAKENHI-PROJECT-17H03986

  • [Journal Article] A substrate-trapping strategy to find E3 ubiquitin ligase substrates identifies Parkin and TRIM28 targets2020
    • Author(s)
      Watanabe Masashi、Saeki Yasushi、Takahashi Hidehisa、Ohtake Fumiaki、Yoshida Yukiko、Kasuga Yusuke、Kondo Takeshi、Yaguchi Hiroaki、Suzuki Masanobu、Ishida Hiroki、Tanaka Keiji、Hatakeyama Shigetsugu
    • Journal Title

      Communications Biology

      Volume: 3 Issue: 1 Pages: 592-592

    • DOI

      10.1038/s42003-020-01328-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K22408, KAKENHI-PUBLICLY-19H05280, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-18H02378, KAKENHI-PROJECT-18H02607, KAKENHI-PROJECT-19K22401, KAKENHI-PLANNED-18H05498, KAKENHI-PROJECT-17H03986

  • [Journal Article] Stress- and ubiquitylation-dependent phase separation of the proteasome2020
    • Author(s)
      Yasuda Sayaka、Tsuchiya Hikaru、Kaiho Ai、Guo Qiang、Ikeuchi Ken、Endo Akinori、Arai Naoko、Ohtake Fumiaki、Murata Shigeo、Inada Toshifumi、Baumeister Wolfgang、Fernandez-Busnadiego Ruben、Tanaka Keiji、Saeki Yasushi
    • Journal Title

      Nature

      Volume: 578 Issue: 7794 Pages: 296-300

    • DOI

      10.1038/s41586-020-1982-9

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05498, KAKENHI-PLANNED-18H05500, KAKENHI-PUBLICLY-19H05281, KAKENHI-PROJECT-18H03993, KAKENHI-PROJECT-18H04022, KAKENHI-PROJECT-18K14913, KAKENHI-PROJECT-26000014, KAKENHI-PROJECT-17H03986, KAKENHI-PROJECT-19H00997

  • [Journal Article] Loss of Parkin contributes to mitochondrial turnover and dopaminergic neuronal loss in aged mice.2020
    • Author(s)
      Noda S, Sato S, Fukuda T, Tada N, Uchiyama Y, Tanaka K, Hattori N.
    • Journal Title

      Neurobiol Dis.

      Volume: 136 Pages: 104717-104717

    • DOI

      10.1016/j.nbd.2019.104717

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07850, KAKENHI-PROJECT-19K22603, KAKENHI-PROJECT-18H04043, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-19K23782

  • [Journal Article] The PINK1-Parkin axis: An Overview.2020
    • Author(s)
      Tanaka K.
    • Journal Title

      Neurosci Res.

      Volume: S0168-0102 Pages: 30571-1

    • DOI

      10.1016/j.neures.2020.01.006

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-26000014

  • [Journal Article] Thymoproteasome and peptidic self2019
    • Author(s)
      Takahama Y, Ohigashi I, Murata S, Tanaka K.
    • Journal Title

      Immunogenetics

      Volume: 71 Issue: 3 Pages: 217-221

    • DOI

      10.1007/s00251-018-1081-3

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08884, KAKENHI-PROJECT-16H02630, KAKENHI-PROJECT-25221102, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-26000014

  • [Journal Article] Detection of ubiquitination activity and identification of ubiquitinated substrates using TR-TUBE2019
    • Author(s)
      Yoshida, Y., Saeki, Y., Tsuchiya, H., and Tanaka, K.
    • Journal Title

      Methods Enzymol

      Volume: 618 Pages: 135-147

    • DOI

      10.1016/bs.mie.2018.12.032

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K14913, KAKENHI-ORGANIZER-18H05497, KAKENHI-PROJECT-18H03993, KAKENHI-PROJECT-16K07705, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-19H02926, KAKENHI-PROJECT-26000014

  • [Journal Article] Parkin recruitment to impaired mitochondria for nonselective ubiquitylation is facilitated by MITOL2019
    • Author(s)
      Koyano Fumika、Yamano Koji、Kosako Hidetaka、Tanaka Keiji、Matsuda Noriyuki
    • Journal Title

      Journal of Biological Chemistry

      Volume: 294 Issue: 26 Pages: 10300-10314

    • DOI

      10.1074/jbc.ra118.006302

    • NAID

      120006959752

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08635, KAKENHI-PROJECT-18K06237, KAKENHI-PROJECT-18K14708, KAKENHI-PLANNED-18H05500, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-26000014, KAKENHI-PROJECT-18H02443

  • [Journal Article] Trans-omics impact of thymoproteasome in cortical thymic epithelial cells.2019
    • Author(s)
      Ohigashi I, Tanaka Y, Kondo K, Fujimori S, Kondo H, Palin A, Hoffmann V, Kozai M, Matsushita Y, Uda S, Motosugi R, Hamazaki J, Kubota H, Murata S, Tanaka K, Katagiri T, Kosako H, Takahama Y
    • Journal Title

      Cell Reports

      Volume: 29 Issue: 9 Pages: 2901-2916

    • DOI

      10.1016/j.celrep.2019.10.079

    • NAID

      120006894616

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07062, KAKENHI-PLANNED-17H06419, KAKENHI-PUBLICLY-18H04801, KAKENHI-PLANNED-18H05500, KAKENHI-PROJECT-16H02630, KAKENHI-PROJECT-18H04022, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-18H02431, KAKENHI-PROJECT-17K08884, KAKENHI-PROJECT-26000014, KAKENHI-PLANNED-16H06577

  • [Journal Article] Parkin‐mediated ubiquitylation redistributes MITOL/March5 from mitochondria to peroxisomes2019
    • Author(s)
      Koyano Fumika、Yamano Koji、Kosako Hidetaka、Kimura Yoko、Kimura Mayumi、Fujiki Yukio、Tanaka Keiji、Matsuda Noriyuki
    • Journal Title

      EMBO reports

      Volume: 20 Issue: 12

    • DOI

      10.15252/embr.201947728

    • NAID

      120006942558

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08635, KAKENHI-PROJECT-18K06237, KAKENHI-PROJECT-18K14708, KAKENHI-PLANNED-18H05500, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-17H03675, KAKENHI-PROJECT-26000014, KAKENHI-PLANNED-19H05712, KAKENHI-PROJECT-18H02443

  • [Journal Article] Structural insights into ubiquitin recognition and Ufd1 interaction of Npl42019
    • Author(s)
      Sato Yusuke、Tsuchiya Hikaru、Yamagata Atsushi、Okatsu Kei、Tanaka Keiji、Saeki Yasushi、Fukai Shuya
    • Journal Title

      Nature Communications

      Volume: 10 Issue: 1 Pages: 5708-5708

    • DOI

      10.1038/s41467-019-13697-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05498, KAKENHI-PLANNED-18H05501, KAKENHI-PROJECT-18H03993, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-19H03162, KAKENHI-PROJECT-18K14913, KAKENHI-PROJECT-26000014

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    • Author(s)
      Ohtake, F., Tsuchiya, H., Tanaka, K., and Saeki, Y.
    • Journal Title

      Methods Enzymol

      Volume: 618 Pages: 105-133

    • DOI

      10.1016/bs.mie.2018.12.019

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K14913, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05498, KAKENHI-PROJECT-18H03993, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-17H03986, KAKENHI-PROJECT-16K14702

  • [Journal Article] Collided ribosomes form a unique structural interface to induce Hel2‐driven quality control　pathways2019
    • Author(s)
      Ikeuchi Ken、Tesina Petr、Matsuo Yoshitaka、Sugiyama Takato、Cheng Jingdong、Saeki Yasushi、Tanaka Keiji、Becker Thomas、Beckmann Roland、Inada Toshifumi
    • Journal Title

      The EMBO Journal

      Volume: 38 Issue: 5

    • DOI

      10.15252/embj.2018100276

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-INTERNATIONAL-15K21743, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05498, KAKENHI-PLANNED-26116003, KAKENHI-PROJECT-18H03993, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-26000014

  • [Journal Article] Sugar-Recognizing Ubiquitin Ligases: Action Mechanisms and Physiology.2019
    • Author(s)
      Yoshida Y, Mizushima T, Tanaka K.
    • Journal Title

      Front Physiol.

      Volume: 10 Pages: 104-104

    • DOI

      10.3389/fphys.2019.00104

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K07705, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-19H02926, KAKENHI-PROJECT-26000014

  • [Journal Article] Endosomal Rab cycles regulate Parkin-mediated mitophagy.2018
    • Author(s)
      Yamano K, Wang C, Sarraf SA, Münch C, Kikuchi R, Noda NN, Hizukuri Y, Kanemaki MT, Harper W, Tanaka K, Matsuda N, Youle RJ.
    • Journal Title

      eLife

      Volume: 7

    • DOI

      10.7554/elife.31326

    • NAID

      120006457172

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K15091, KAKENHI-PLANNED-25111004, KAKENHI-PROJECT-16K15095, KAKENHI-PROJECT-16K18545, KAKENHI-PROJECT-26000014, KAKENHI-PUBLICLY-18H04719, KAKENHI-PROJECT-18H02170, KAKENHI-PROJECT-18H02443

  • [Journal Article] Structural insights into ubiquitin phosphorylation by PINK12018
    • Author(s)
      Okatsu Kei、Sato Yusuke、Yamano Koji、Matsuda Noriyuki、Negishi Lumi、Takahashi Akiko、Yamagata Atsushi、Goto-Ito Sakurako、Mishima Masaki、Ito Yutaka、Oka Toshihiko、Tanaka Keiji、Fukai Shuya
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 10382-10382

    • DOI

      10.1038/s41598-018-28656-8

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-17H05887, KAKENHI-PUBLICLY-17H05888, KAKENHI-PLANNED-18H05501, KAKENHI-PROJECT-16H04749, KAKENHI-PROJECT-16H04750, KAKENHI-PROJECT-17H03676, KAKENHI-PROJECT-18H02443, KAKENHI-PROJECT-26000014

  • [Journal Article] Loss of autophagy in dopaminergic neurons causes Lewy pathology and motor dysfunction in aged mice.2018
    • Author(s)
      Sato S, Uchihara T, Fukuda T, Noda S, Kondo H, Saiki S, Komatsu M, Uchiyama Y, Tanaka K, Hattori N.
    • Journal Title

      Sci Rep.

      Volume: ８ Issue: 1 Pages: 2813-2813

    • DOI

      10.1038/s41598-018-21325-w

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K06780, KAKENHI-PROJECT-17K07797, KAKENHI-PROJECT-16K14572, KAKENHI-PLANNED-25111006, KAKENHI-PLANNED-25111007, KAKENHI-PROJECT-15H04842, KAKENHI-PROJECT-15H04843, KAKENHI-PROJECT-17H03555, KAKENHI-PROJECT-26000014, KAKENHI-PROJECT-18H04043

  • [Journal Article] K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains.2018
    • Author(s)
      Ohtake, F., Tsuchiya, H., Saeki, Y., and Tanaka, K
    • Journal Title

      PNAS

      Volume: 115 Issue: 7 Pages: 1401-1408

    • DOI

      10.1073/pnas.1716673115

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K14702, KAKENHI-PROJECT-26293018, KAKENHI-PROJECT-17H03986, KAKENHI-PROJECT-26000014

  • [Journal Article] HERC2 facilitates BLM and WRN helicase complex interaction with RPA to suppress G-quadruplex DNA.2018
    • Author(s)
      Wu, W., Rokutanda, N., Takeuchi, J., Lai, Y., Maruyama, R., Togashi, Y., Nishikawa, H., Arai, N., Miyoshi, Y., Suzuki, N., Saeki, Y., Tanaka, K., and Ohta, T.
    • Journal Title

      Cancer Res.

      Volume: 78 Pages: 6371-6385

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Journal Article] Accelerated invagination of vacuoles as a stress response in chronically heat-stressed yeasts.2018
    • Author(s)
      Ishii, A., Kawai, K., Noda, H., Kato, H., Takeda, K., Asakawa, K., Ichikawa, Y., Sasanami, T., Tanaka, K., and Kimura, Y.
    • Journal Title

      Sci Rep.

      Volume: 8 Issue: 1 Pages: 2-644

    • DOI

      10.1038/s41598-018-20781-8

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26000014, KAKENHI-PROJECT-17H03902

  • [Journal Article] Ub-ProT reveals global length and composition of protein ubiquitylation in cells2018
    • Author(s)
      Tsuchiya, H., Burana, D., Ohtake, F., Arai, N., Kaiho, A., Komada, M., Tanaka,K., and Saeki, Y.
    • Journal Title

      Nature Commun

      Volume: 9 Issue: 1 Pages: 524-524

    • DOI

      10.1038/s41467-018-02869-x

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K14702, KAKENHI-PROJECT-26293018, KAKENHI-PUBLICLY-17H05681, KAKENHI-PROJECT-17H03986, KAKENHI-PROJECT-26000014

  • [Journal Article] Reactive oxygen species up-regulate expression of muscle atrophy-associated ubiquitin ligase Cbl-b in rat L6 skeletal muscle cells.2018
    • Author(s)
      Yuushi Okumura et al.
    • Journal Title

      Am J Physiol Cell Physiol.

      Volume: 印刷中 Issue: 6 Pages: C721-C731

    • DOI

      10.1152/ajpcell.00184.2017

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09585, KAKENHI-ORGANIZER-15H05935, KAKENHI-PLANNED-15H05937, KAKENHI-PROJECT-15H04931, KAKENHI-PROJECT-15J40096, KAKENHI-PROJECT-26000014, KAKENHI-PROJECT-18K08453, KAKENHI-PLANNED-15H05936, KAKENHI-PUBLICLY-18H04981

  • [Journal Article] Cytosolic N-Glycans : Triggers for Ubiquitination Directing Proleasomal and Autophagic Degradation : Molecular Systems for Monitoring Cytosolic N-Glycans as Signals for Unwanted Proteins and Organelles.2018
    • Author(s)
      Yoshida, Y. and Tanaka, K.
    • Journal Title

      BioEssays

      Volume: 40 Issue: 3

    • DOI

      10.1002/bies.201700215

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26000014, KAKENHI-PROJECT-16K07705

  • [Journal Article] The immunoproteasome and thymoproteasome: functions, evolution and human disease2018
    • Author(s)
      Murata S, Takahama Y, Kasahara M, Tanaka K
    • Journal Title

      Nature Immunol.

      Volume: 19 Issue: 9 Pages: 923-931

    • DOI

      10.1038/s41590-018-0186-z

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-ORGANIZER-18H05497, KAKENHI-PROJECT-16H02630, KAKENHI-PROJECT-25221102, KAKENHI-PROJECT-26000014

  • [Journal Article] Ubiquitination of stalled ribosome triggers ribosome-associated quality control2017
    • Author(s)
      Matsuo Y, Ikeuchi K, Saeki Y, Iwasaki S, Schmidt C, Udagawa T, Sato F, Tsuchiya H, Becker T, Tanaka K, Ingolia NT, Beckmann R, Inada T
    • Journal Title

      Nature Communications

      Volume: 8 Issue: 1 Pages: 159-159

    • DOI

      10.1038/s41467-017-00188-1

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07243, KAKENHI-PROJECT-26293018, KAKENHI-PLANNED-26116003, KAKENHI-PROJECT-16K18486, KAKENHI-PROJECT-26000014, KAKENHI-PUBLICLY-17H05679, KAKENHI-PROJECT-17H04998

  • [Journal Article] In Vivo Ubiquitin Linkage-type Analysis Reveals that the Cdc48-Rad23/Dsk2 Axis Contributes to K48-linked Chain Specificity of the Proteasome in Yeast.2017
    • Author(s)
      Tsuchiya, H., Ohtake, F., Arai, N., Kaiho, A., Yasuda, S., Tanaka, K., and Saeki, Y.
    • Journal Title

      Mol Cell

    • Description
      【掲載確定】 in press
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Journal Article] In vivo ubiquitin linkage-type analysis reveals that the Cdc48-Rad23/Dsk2 axis contributes to K48-linked chain specificity of the proteasome.2017
    • Author(s)
      Tsuchiya, H., Ohtake, F., Arai, N., Kaiho, A., Yasuda, S., Tanaka, K., and Saeki, Y.
    • Journal Title

      Mol. Cell

      Volume: 66 Issue: 4 Pages: 488-502

    • DOI

      10.1016/j.molcel.2017.04.024

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26293018, KAKENHI-PROJECT-26000014

  • [Journal Article] Crystal structure of human proteasome assembly chaperone PAC4 involved in proteasome formation2017
    • Author(s)
      Eiji Kurimoro, Tadashi Satoh, Yuri Ito, Eri Ishihara, Kenta Okamoto, Maho Yagi-Utsumi, Keiji Tanaka, and Koichi Kato
    • Journal Title

      Protein Sci.

      Volume: 26 Issue: 5 Pages: 1080-1085

    • DOI

      10.1002/pro.3153

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H02491, KAKENHI-PROJECT-15K21680, KAKENHI-PROJECT-17K15441, KAKENHI-ORGANIZER-25102001, KAKENHI-PLANNED-25102008, KAKENHI-PROJECT-26000014

  • [Journal Article] Ubiquitination of exposed glycoproteins by SCFFBXO27 directs damaged lysosomes for autophagy.2017
    • Author(s)
      Yoshida Y, Yasuda S, Fujita T, Hamasaki M, Murakami A, Kawawaki J, Iwai K, Saeki Y, Yoshimori T, Matsuda N, Tanaka K
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 114 Issue: 32 Pages: 8574-8579

    • DOI

      10.1073/pnas.1702615114

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07705, KAKENHI-WRAPUP-17H06078, KAKENHI-PLANNED-25111002, KAKENHI-PROJECT-17H06174, KAKENHI-PROJECT-15H04371, KAKENHI-PROJECT-26000014

  • [Journal Article] Purkinje Cells Are More Vulnerable to the Specific Depletion of Cathepsin D Than to That of Atg72017
    • Author(s)
      Koike Masato、Shibata Masahiro、Sunabori Takehiko、Yamaguchi Junji、Sakimura Kenji、Komatsu Masaaki、Tanaka Keiji、Uchiyama Yasuo
    • Journal Title

      The American Journal of Pathology

      Volume: 187 Issue: 7 Pages: 1586-1600

    • DOI

      10.1016/j.ajpath.2017.02.020

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08522, KAKENHI-PROJECT-17K19444, KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-25000015, KAKENHI-PROJECT-26000014

  • [Journal Article] Structural basis for specific cleavage of Lys6-linked polyubiquitin chains by USP302017
    • Author(s)
      Sato Yusuke、Okatsu Kei、Saeki Yasushi、Yamano Koji、Matsuda Noriyuki、Kaiho Ai、Yamagata Atsushi、Goto-Ito Sakurako、Ishikawa Minoru、Hashimoto Yuichi、Tanaka Keiji、Fukai Shuya
    • Journal Title

      Nature Structural & Molecular Biology

      Volume: 24 Issue: 11 Pages: 911-919

    • DOI

      10.1038/nsmb.3469

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K15072, KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26293018, KAKENHI-PROJECT-16H04749, KAKENHI-PROJECT-16H04750, KAKENHI-PROJECT-15J10559, KAKENHI-PROJECT-16K18545, KAKENHI-PROJECT-26000014

  • [Journal Article] A human PSMB11 variant affects thymoproteasome processing and CD8+ T cell production2017
    • Author(s)
      Ohigashi I, Ohte Y, Setoh K, Nakase H, Maekawa A, Kiyonari H, Hamazaki Y, Sekai M, Sudo T, Tabara Y, Sawai H, Omae Y, Yuliwulandari R, Tanaka Y, Mizokami M, Inoue H, Kasahara M, Minato N, Tokunaga K, Tanaka K, Matsuda F, Murata S, Takahama Y.
    • Journal Title

      JCI Insight

      Volume: 2 Issue: 10 Pages: 1-14

    • DOI

      10.1172/jci.insight.93664

    • NAID

      120006733720

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08884, KAKENHI-PROJECT-15K19125, KAKENHI-PUBLICLY-15H01154, KAKENHI-PLANNED-24111008, KAKENHI-PROJECT-16H02630, KAKENHI-PROJECT-17H04123, KAKENHI-PROJECT-15K15151, KAKENHI-PROJECT-26000014, KAKENHI-PROJECT-15H04716

  • [Journal Article] Foxn1-β5t transcriptional axis controls CD8+ T cell production in the thymus.2017
    • Author(s)
      Uddin MM, Ohigashi I, Motosugi R, Nakayama T, Sakata M, Hamazaki J, Nishito Y, Rode I, Tanaka K, Takemoto T, Murata S, Takahama Y.
    • Journal Title

      Nat Commun

      Volume: 8 Issue: 1 Pages: 14419-14419

    • DOI

      10.1038/ncomms14419

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111004, KAKENHI-PROJECT-25221102, KAKENHI-PROJECT-16H02630, KAKENHI-PROJECT-15K19130, KAKENHI-PROJECT-16K08228, KAKENHI-PROJECT-26000014

  • [Journal Article] HTLV-1 Tax induces formation of the active macromolecular IKK complex by generating Lys63- and Met1-linked hybrid polyubiquitin chains.2017
    • Author(s)
      Shibata Y, Tokunaga F, Goto E, Komatsu G, Gohda J, Saeki Y, Tanaka K, Takahashi H, Sawasaki T, Inoue S, Oshiumi H, Seya T, Nakano H, Tanaka Y, Iwai K, and Inoue J.
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      PLoS Pathog.

      Volume: 13 Issue: 12 Pages: e1006162-e1006162

    • DOI

      10.1371/journal.ppat.1006162

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-15H01172, KAKENHI-PUBLICLY-15H01553, KAKENHI-PUBLICLY-16H01192, KAKENHI-PLANNED-16H06575, KAKENHI-PLANNED-16H06579, KAKENHI-PLANNED-24112002, KAKENHI-PLANNED-24112008, KAKENHI-PLANNED-26110003, KAKENHI-PROJECT-15H04694, KAKENHI-PROJECT-16H04729, KAKENHI-PROJECT-26290036, KAKENHI-PROJECT-15K15353, KAKENHI-PROJECT-15K18468, KAKENHI-PROJECT-15K08517, KAKENHI-PROJECT-16K01378, KAKENHI-PROJECT-16K15210, KAKENHI-PROJECT-26000014

  • [Journal Article] Parkinson’s disease-related DJ-1 functions in thiol quality control against aldehyde attack in vitro2017
    • Author(s)
      Matsuda Noriyuki、Kimura Mayumi、Queliconi Bruno Barros、Kojima Waka、Mishima Masaki、Takagi Kenji、Koyano Fumika、Yamano Koji、Mizushima Tsunehiro、Ito Yutaka、Tanaka Keiji
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 12816-12816

    • DOI

      10.1038/s41598-017-13146-0

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-16H00847, KAKENHI-PUBLICLY-17H05887, KAKENHI-PUBLICLY-17H05888, KAKENHI-PROJECT-15H04339, KAKENHI-PROJECT-16F15387, KAKENHI-PROJECT-17J03737, KAKENHI-PROJECT-15K14494, KAKENHI-PROJECT-16K18545, KAKENHI-PROJECT-26000014

  • [Journal Article] Inhibitory effects of local anesthetics on the proteasome and their biological actions2017
    • Author(s)
      Bahrudin, U.; Unno, M.; Nishio, K.; Kita, A.; Li, P.; Kato, M.; Inoue, M.; Tsujitani, S.; Murakami, T.; Sugiyama, R.; Saeki, Y.; Obara, Y.; Tanaka, K.; Yamaguchi, H.; Sakane, I.; Kawata, Y.; Itoh, T.; Ninomiya, H.; Hisatome, I.; Morimoto, Y.
    • Journal Title

      Sci. Rep.

      Volume: 7 Issue: 1 Pages: 5079-5079

    • DOI

      10.1038/s41598-017-04652-2

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26241030, KAKENHI-PROJECT-15K08277, KAKENHI-PROJECT-26000014

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    • Author(s)
      Ishimura R, Obata M, Kageyama S, Daniel J, Tanaka K, Komatsu M.
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      FEBS Lett.

      Volume: 591 Issue: 1 Pages: 196-204

    • DOI

      10.1002/1873-3468.12518

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-16J07037, KAKENHI-PROJECT-26000014

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    • Author(s)
      Yamaguchi J, Suzuki C, Nanao T, Kakuta S, Ozawa K, Tanida I, Saitoh T, Sunabori T, Komatsu M, Tanaka K, Aoki S, Sakimura K, Uchiyama Y.
    • Journal Title

      Autophagy

      Volume: 17 Issue: 5 Pages: 1-14

    • DOI

      10.1080/15548627.2017.1314897

    • NAID

      120006881392

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K12749, KAKENHI-PROJECT-17K19444, KAKENHI-PROJECT-26713005, KAKENHI-PUBLICLY-17H05533, KAKENHI-PUBLICLY-17H06009, KAKENHI-PLANNED-17H06415, KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-26461277, KAKENHI-PROJECT-25000015, KAKENHI-PROJECT-26000014, KAKENHI-PROJECT-17K15550, KAKENHI-PROJECT-16H04650

  • [Journal Article] Structure of the Dnmt1 reader module complexed with a unique two-mono-ubiquitin mark on histone H3 reveals the basis for DNA methylation maintenance.2017
    • Author(s)
      Ishiyama S, Nishiyama A, Saeki Y, Moritsugu K Morimoto D, Yamaguchi L, Arai N, Matsumura R, Kawakami T, Mishima Y, Hojo H, Shimamura S, Ishikawa F, Tajima S, Tanaka K, Ariyoshi M, Shirakawa M, Ikeguchi M, Kidera A, Suetake I, Arita K, Nakanishi M
    • Journal Title

      Mol Cell

      Volume: 68 Issue: 2 Pages: 350-360

    • DOI

      10.1016/j.molcel.2017.09.037

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K14418, KAKENHI-PROJECT-16K14714, KAKENHI-PROJECT-16K18503, KAKENHI-PROJECT-26293018, KAKENHI-PLANNED-26119004, KAKENHI-PROJECT-16H04180, KAKENHI-PROJECT-16H04780, KAKENHI-PROJECT-16H04818, KAKENHI-PROJECT-15K05565, KAKENHI-PROJECT-15K18520, KAKENHI-PROJECT-26000014

  • [Journal Article] The ubiquitin signal and autophagy : an orchestrated dance leading to mitochondrial degradation2016
    • Author(s)
      Koji Yamano, K., Matsuda, N., and Tanaka, K.
    • Journal Title

      EMBO Rep.

      Volume: 17 Issue: 3 Pages: 300-3016

    • DOI

      10.15252/embr.201541486

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26000014, KAKENHI-PUBLICLY-15H01196

  • [Journal Article] Structural analysis of a function-associated loop mutant of the substrate recognition domain of Fbs1 ubiquitin ligase.2016
    • Author(s)
      Nishio, K., Yoshida, Y., Tanaka, K., Mizushima, T.
    • Journal Title

      Acta Crystallographica Section F

      Volume: 72 Issue: 8 Pages: 619-626

    • DOI

      10.1107/s2053230x16011018

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PLANNED-24112009, KAKENHI-PROJECT-26000014

  • [Journal Article] p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming2016
    • Author(s)
      Saito T, Ichimura Y, Taguchi K, Suzuki T, Mizushima T, Takagi K, Hirose Y, Nagahashi M, Iso T, Fukutomi T, Ohishi M, Endo K, Uemura T, Nishito Y, Okuda S, Obata M, Kouno T, Imamura R, Tada Y, Obata R, Yasuda D, Takahashi K, Fujimura T, Pi J, Lee MS, Ueno T, Ohe T, Mashino T, Wakai T, Kojima H, Okabe T, Nagano T et al.
    • Journal Title

      Nature Commun

      Volume: 7 Issue: 1 Pages: 12030-12030

    • DOI

      10.1038/ncomms12030

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-16H01190, KAKENHI-PLANNED-24112009, KAKENHI-PLANNED-25111006, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-26242088, KAKENHI-PROJECT-26253019, KAKENHI-PROJECT-15H04670, KAKENHI-PROJECT-15H04692, KAKENHI-PROJECT-16H05137, KAKENHI-PROJECT-26460354, KAKENHI-PROJECT-26460384, KAKENHI-PROJECT-16K15228, KAKENHI-PROJECT-26830080, KAKENHI-PROJECT-16K10565, KAKENHI-PROJECT-15KK0325, KAKENHI-PROJECT-26000014

  • [Journal Article] Biallelic Variants in UBA5 Link Dysfunctional UFM1 Ubiquitin-like Modifier Pathway to Severe Infantile-Onset Encephalopathy.2016
    • Author(s)
      Muona M, Ishimura R, Laari A,...... , Komatsu M.
    • Journal Title

      Am J Hum Genet.

      Volume: 99 Issue: 3 Pages: 683-94

    • DOI

      10.1016/j.ajhg.2016.06.020

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-16H05137, KAKENHI-PROJECT-16J07037, KAKENHI-PROJECT-26830080, KAKENHI-PROJECT-15K18373, KAKENHI-PROJECT-26000014

  • [Journal Article] The Ankrd13 family of ubiquitin-interacting motif-bearing proteins regulates valosin-containing protein/p97 protein-mediated lysosomal trafficking of caveolin I.2016
    • Author(s)
      Burana, D., Yoshihara, H., Tanno, H., Yamamoto, A., Saeki, Y., Tanaka, K., and Komada, M.
    • Journal Title

      J Biol Chem.

      Volume: 291 Pages: 6218-6231

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Journal Article] Unexpected mitochondrial matrix localization of Parkinson's disease-related DJ-1 mutants but not wild type DJ-1.2016
    • Author(s)
      Kojima, W., Kujuro, Y., Okatsu, K., Bruno, Q., Koyano, F., Kimura, M., Yamano, K., Tanaka, K., and Matsuda, N.
    • Journal Title

      Genes to Cells

      Volume: 21 Issue: 7 Pages: 772-788

    • DOI

      10.1111/gtc.12382

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PUBLICLY-15H01196, KAKENHI-PROJECT-26000014

  • [Journal Article] Essential role of specialized proteasome subunits in thymic selection of CD8 T cells2016
    • Author(s)
      Kincaid, E. Z. Murata, S., Tanaka, K., and Rock, K. L.
    • Journal Title

      Nat Immunol

    • Description
      【掲載確定】 in press
    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Journal Article] Ankrd13 family of ubiquitin-interacting motif-bearing proteins regulates VCP/p97-mediated lysosomal traffic of caveolin-1.2016
    • Author(s)
      Burana, D., Yoshihara, H., Tanno, H., Yamamoto, A., Saeki, Y., Tanaka, K., and Komada, M.
    • Journal Title

      J. Biol. Chem.

      Volume: 291 Issue: 12 Pages: 6218-6231

    • DOI

      10.1074/jbc.m115.710707

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-24112003, KAKENHI-PROJECT-15H04293, KAKENHI-PROJECT-26000014, KAKENHI-PLANNED-24112008

  • [Journal Article] p62/Sqstml promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming.2016
    • Author(s)
      Saito, T., Ichimura, Y., Taguchi, K., Suzuki, T., Mizushima, T., Takagi, K., Hirose, Y., Nagahashi, M., Iso, T., Fukutomi, T., Ohishi, M., Endo, K., Uemura, T., Nishito, Y., Okuda, S., Obata, M., Kouno, T., Imamura, R., Tada, Y., Obata, R., Yasuda, D., Takahashi, K., Fujimura, T., Pi, J., Lee, M-S., Ueno, T., Ohe, T., Mashino, T., Wakai, T., Kojima, H., Okabe, T., Nagano, T., Motohashi, H., Waguri, S., Soga, T., Yamamoto, M., Tanaka, K., and Komatsu, M.
    • Journal Title

      Nat Commun.

    • Description
      【掲載確定】 in press
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Journal Article] The K48-K63 branched ubiquitin chain regulates NF-kappaB signaling2016
    • Author(s)
      Ohtake F, Saeki Y, Ishido S, Kanno J, Tanaka K
    • Journal Title

      Mol. Cell

      Volume: 64 Issue: 2 Pages: 251-266

    • DOI

      10.1016/j.molcel.2016.09.014

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-24112003, KAKENHI-PLANNED-24112008, KAKENHI-PROJECT-26000014, KAKENHI-PLANNED-24112004, KAKENHI-PROJECT-16K14702

  • [Journal Article] The E3 ubiquitin ligase TRIM23 regulates adipocyte differentiation via stabilization of the adipocyte activator PPAR gamma.2015
    • Author(s)
      Watanabe, M., Takahashi, H., Saeki, Y., Ozaki, T., Itoh, S., Suzuki, M., Mizushima, W., Tanaka, K. and Hatakeyama, S.
    • Journal Title

      eLIFE

      Volume: 4

    • DOI

      10.7554/elife.05615

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25860201, KAKENHI-PROJECT-15K15058, KAKENHI-PLANNED-24112006, KAKENHI-PLANNED-24112008, KAKENHI-PLANNED-24118002, KAKENHI-PROJECT-15H04690, KAKENHI-PROJECT-15H04701, KAKENHI-PROJECT-26670130, KAKENHI-PROJECT-26000014

  • [Journal Article] TCR affinity for thymoproteasome-dependent positively selecting peptides conditions antigen responsiveness in CD8(+) T cells2015
    • Author(s)
      Takada K, Van Laethem F, Xing Y, Akane K, Suzuki H, Murata S, Tanaka K, Jameson SC, Singer A, Takahama Y.
    • Journal Title

      Nature Immunology

      Volume: 16 Issue: 10 Pages: 1069-1076

    • DOI

      10.1038/ni.3237

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460576, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111004, KAKENHI-PROJECT-25221102, KAKENHI-PROJECT-26000014

  • [Journal Article] Thymoproteasomes produce unique peptide motifs for positive selection of CD8(+) T cells.2015
    • Author(s)
      Sasaki K, Takada K, Ohte Y, Kondo H, Sorimachi H, Tanaka K, Takahama Y, Murata S.
    • Journal Title

      Nature Communications

      Volume: 6 Issue: 1 Pages: 7484-7484

    • DOI

      10.1038/ncomms8484

    • NAID

      120006999409

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26460576, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111004, KAKENHI-PROJECT-25221102, KAKENHI-PROJECT-14J12345, KAKENHI-PROJECT-26000014

  • [Journal Article] Mutations in the deubiquitinase gene USP8 cause Cushing’s disease2015
    • Author(s)
      Reincke M, Sbiera S, Hayakawa A, Theodoropoulou M, Osswald A, Beuschlein F, Meitinger T, Mizuno-Yamasaki E, Kawaguchi K, Saeki Y, Tanaka K, Wieland T, Graf E, Saeger W, Ronchi CL, Allolio B, Buchfelder M, Strom TM, Fassnacht M & Komada M
    • Journal Title

      Nat. Genet.

      Volume: 47 Issue: 1 Pages: 31-38

    • DOI

      10.1038/ng.3166

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PLANNED-24112003, KAKENHI-PLANNED-24112008, KAKENHI-PROJECT-26000014

  • [Journal Article] Nedd4-induced mono-ubiquitination of IRS-2 enhances IGF signaling and mitogenic activity.2015
    • Author(s)
      Toshiaki Fukushima, Hidehito Yoshihara, Haruka Furuta, Fumihiko Hakuno, Jing Luan, Cunming Duan, Yasushi Saeki, Keiji Tanaka, Shun-Ichiro Iemura, TohruNatsume, Kazuhiro Chida, Yusuke Nakatsu, Hideaki Kamata, Tomoichiro Asano, and Shin-Ichiro Takahashi
    • Journal Title

      Nature communications

      Volume: 6 Issue: 1 Pages: 6780-6780

    • DOI

      10.1038/ncomms7780

    • NAID

      120006348510

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23370062, KAKENHI-PROJECT-24380152, KAKENHI-PROJECT-24657092, KAKENHI-PROJECT-24790928, KAKENHI-PROJECT-25850220, KAKENHI-PROJECT-26460369, KAKENHI-PUBLICLY-15H01382, KAKENHI-PUBLICLY-15H01406, KAKENHI-PLANNED-24112008, KAKENHI-ORGANIZER-24115001, KAKENHI-PLANNED-24115007, KAKENHI-PROJECT-25221204, KAKENHI-PROJECT-15H04583, KAKENHI-PROJECT-26000014

  • [Journal Article] VCP/Cdc48 rescues the growth defect of a GPI10 mutant in yeast.2015
    • Author(s)
      Ohnuma Y, Takata T, Kawawaki J, Yasuda K, Tanaka K, Kimura Y, Kakizuka A.
    • Journal Title

      FEBS Lett.

      Volume: 589 Issue: 5 Pages: 576-80

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      10.1016/j.febslet.2015.01.017

    • NAID

      120005531440

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24249082, KAKENHI-PROJECT-26440070, KAKENHI-PROJECT-26000014

  • [Journal Article] The unexpected role of polyubiquitin chains in the formation of fibrillar aggregates.2015
    • Author(s)
      Morimoto D,Walinda E, Fukada H, Sou YS, Kageyama S, Hoshino M, Fujii T, Tsuchiya H, Saeki Y, Arita K, Ariyoshi M, Tochio H, Iwai K, Namba K, Komatsu M, Tanaka K, Shirakawa M.
    • Journal Title

      Nat Commun.

      Volume: 6 Issue: 1 Pages: 6116-6116

    • DOI

      10.1038/ncomms7116

    • NAID

      120005528125

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-21121006, KAKENHI-ORGANIZER-24112001, KAKENHI-PLANNED-24112002, KAKENHI-PLANNED-24112008, KAKENHI-PROJECT-25000013, KAKENHI-PLANNED-25111006, KAKENHI-PUBLICLY-25112514, KAKENHI-PLANNED-26119004, KAKENHI-PROJECT-26440025, KAKENHI-PROJECT-26860224, KAKENHI-PROJECT-25253019, KAKENHI-PROJECT-26000014

  • [Journal Article] Conserved Mode of Interaction between Yeast Bro1 Family V Domains and YP(X)nL Motif-Containing Target Proteins2015
    • Author(s)
      Yoko Kimura, Mirai Tanigawa, Junko Kawawaki, Kenji Takagi, Tsunehiro Mizushima, Tatsuya Maeda, Keiji Tanaka
    • Journal Title

      Eukaryotic Cell

      Volume: 14 Issue: 10 Pages: 976-982

    • DOI

      10.1128/ec.00091-15

    • NAID

      120005671359

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26440070, KAKENHI-PLANNED-24112009, KAKENHI-PROJECT-25291042, KAKENHI-PROJECT-26000014

  • [Journal Article] Thymoproteasomes produce unique peptide motifs for positive selection of CD8+ T cells2015
    • Author(s)
      Katsuhiro Sasakil, Kensuke Takada, Yuki Ohte, Hiroyuki Kondo, Hiroyuki Sorimachi, Keiji Tanaka, Yousuke Takahama, Shigeo Murata
    • Journal Title

      Nat Commun. in press

    • NAID

      120006999409

    • Description
      印刷中
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Journal Article] Site-specific Interaction Mapping of Phosphorylated Ubiquitin to Uncover Parkin Activation.2015
    • Author(s)
      Koji Yamano, Bruno B. Queliconi, Fumika Koyano, Yasushi Saeki, Takatsugu Hirokawa, Keiji Tanaka§,and Noriyuki Matsuda
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 290 Issue: 42 Pages: 25199-25211

    • DOI

      10.1074/jbc.m115.671446

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K19037, KAKENHI-PUBLICLY-15H01196, KAKENHI-PLANNED-24112008, KAKENHI-PUBLICLY-26111729, KAKENHI-PROJECT-26650042, KAKENHI-PROJECT-26000014

  • [Journal Article] Ubiquitin acetylation inhibits polyubiquitin chain elongation.2015
    • Author(s)
      Ohtake F, Saeki Y, Sakamoto K, Ohtake K, Nishikawa H, Tsuchiya H, Ohta T, Tanaka K, Kanno J.
    • Journal Title

      EMBO Rep.

      Volume: 16 Issue: 2 Pages: 192-201

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      10.15252/embr.201439152

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-24112005, KAKENHI-PLANNED-24112008, KAKENHI-PROJECT-26290042, KAKENHI-PROJECT-26291035, KAKENHI-PROJECT-26670730, KAKENHI-PROJECT-26870853, KAKENHI-PLANNED-24112004, KAKENHI-PROJECT-26000014

  • [Journal Article] Parkin receptor on damaged mitochondria revisited -uncovering the role of phosphorylated ubiquitin chain2015
    • Author(s)
      Matsuda, N. and Tanaka, K.
    • Journal Title

      Autophagy

      Volume: 11 Issue: 9 Pages: 1700-1701

    • DOI

      10.1080/15548627.2015.1071760

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Journal Article] The Structural Differences between a Glycoprotein Specific F-Box Protein Fbs1 and Its Homologous Protein FBG3.2015
    • Author(s)
      Kumanomidou T, Nishio K, Takagi K, Nakagawa T, Suzuki A, Yamane T, Tokunaga F, Iwai K, Murakami A, Yoshida Y, Tanaka K, Mizushima T.
    • Journal Title

      PLoS One.

      Volume: 10 Issue: 10 Pages: e0140366-e0140366

    • DOI

      10.1371/journal.pone.0140366

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K08259, KAKENHI-PUBLICLY-15H01172, KAKENHI-PLANNED-24112009, KAKENHI-PROJECT-15H04694, KAKENHI-PROJECT-26000014, KAKENHI-PLANNED-24112002, KAKENHI-PROJECT-25253019

  • [Journal Article] Measurement of proteasome activity in peripheral blood mononuclear cells as an indicator of susceptibility to bortezomib-induced severe neurological adverse events in patients with multiple myeloma2015
    • Author(s)
      Cho, Y., Hori, M., Okoshi, Y., Fujisawa, F., Shinagawa, A., Kudo, D., Komeno, T., Yoshida, C., Katsura, Y., Ota, I., Shimizu, S., Kamoshita, M., Sasaki, K., Tanaka, K., Mukai, H. Y., and Kojima, H.
    • Journal Title

      Acta Haematol.

      Volume: 134 Issue: 1 Pages: 25-31

    • DOI

      10.1159/000369445

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Journal Article] Phosphorylated ubiquitin chain is the genuine Parkin receptor.2015
    • Author(s)
      K. Okatsu, F. Koyano, M. Kimura, H. Kosako, Y. Saeki, K. Tanaka and N. Matsuda
    • Journal Title

      The Journal of Cell Biology

      Volume: 209 Issue: 1 Pages: 111-128

    • DOI

      10.1083/jcb.201410050

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26440101, KAKENHI-PROJECT-15K19037, KAKENHI-PUBLICLY-15H01196, KAKENHI-PLANNED-24112008, KAKENHI-PUBLICLY-26111729, KAKENHI-PROJECT-26650042, KAKENHI-PROJECT-26000014

  • [Journal Article] A comprehensive method for detecting ubiquitinated substrates using TR-TUBE2015
    • Author(s)
      Yoshida, Y., Saeki, Y., Murakami, A., Kawawaki, J., Tsuchiya, H., Yoshihara, H., Shindo, M., and Tanaka, K.
    • Journal Title

      Proc. Natl. Acad. Sci. USA.

      Volume: 112 Issue: 15 Pages: 4630-4635

    • DOI

      10.1073/pnas.1422313112

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-24112008, KAKENHI-PROJECT-26000014

  • [Journal Article] Unconventional PINK1 localization mechanism to the outer membrane of depolarized mitochondria drives Parkin recruitment2015
    • Author(s)
      Okatsu, K., Kimura, M., Oka, T., Tanaka, K., and Matsuda N.
    • Journal Title

      J Cell Sci

      Volume: 128 Pages: 964-978

    • DOI

      10.1242/jcs.161000

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26000014, KAKENHI-PROJECT-26440106, KAKENHI-PUBLICLY-15H01196, KAKENHI-PUBLICLY-26111729, KAKENHI-PROJECT-26650042

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    • Author(s)
      Matsuda, N. and Tanaka, K.
    • Journal Title

      Nature (News and Views)

      Volume: 524 Issue: 7565 Pages: 294-295

    • DOI

      10.1038/nature15199

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Journal Article] Liganded ERα stimulates the E3 ubiquitin ligase activity of UBE3C to facilitate cell proliferation2015
    • Author(s)
      Okada M, Ohtake F, Nishikawa H, Wu W, Saeki Y, Takana K, Ohta T
    • Journal Title

      Molecular Endocrinology

      Volume: 29 Issue: 11 Pages: 1646-1657

    • DOI

      10.1210/me.2015-1125

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26460402, KAKENHI-PLANNED-24112005, KAKENHI-PLANNED-24112008, KAKENHI-PUBLICLY-26102741, KAKENHI-PROJECT-26670730, KAKENHI-PROJECT-26290042, KAKENHI-PROJECT-26000014

  • [Journal Article] Modification of ASC1 by UFM1 is crucial for ERα transactivation and breast cancer development.2014
    • Author(s)
      Yoo, HM., Kang, SH., Kim, JY., Lee, JE., Seong, MW., Lee, SW., Ka, SH., Sou,YS., Komatsu, M., Tanaka, K., Lee, ST., Noh, DY., Baek, SH., Jeon, YJ., *Chung, CH.
    • Journal Title

      Mol. Cell

      Volume: 56 Issue: 2 Pages: 261-274

    • DOI

      10.1016/j.molcel.2014.08.007

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-26000014, KAKENHI-PROJECT-26650012

  • [Journal Article] LC3B is indispensable for selective autophagy of p62 but not basal autophagy.2014
    • Author(s)
      Maruyama Y, Sou YS, Kageyama S, Takahashi T, Ueno T, Tanaka K, Komatsu M, Ichimura Y.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 446 Issue: 1 Pages: 309-315

    • DOI

      10.1016/j.bbrc.2014.02.093

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24790332, KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-25460400, KAKENHI-PROJECT-26000014

  • [Journal Article] Dissection of the role of p62/Sqstml in activation of Nrf2 during xenophagy.2014
    • Author(s)
      Ishimura, R., Tanaka, K., and Komatsu, M.
    • Journal Title

      FEBS Lett.

      Volume: 588 Issue: 5 Pages: 822-828

    • DOI

      10.1016/j.febslet.2014.01.045

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012, KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-26000014

  • [Journal Article] The ESCRT-III adaptor protein Brol controls functions of regulator for free ubiauitin chains 1 (Rful) in ubiquitin homeostasis2014
    • Author(s)
      Kimura Y, Kawawaki J, Kakiyama Y, Shimoda A, and Tanaka K
    • Journal Title

      J Biol Chem

      Volume: 289 Issue: 31 Pages: 21760-21769

    • DOI

      10.1074/jbc.m114.550871

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26000014, KAKENHI-PROJECT-26440070

  • [Journal Article] The significant role of autophagy in the granular layer in normal skin differentiation and hair growth.2014
    • Author(s)
      Yoshihara, N., Ueno, T., Takagi, A., Trejo, JA., Haruna, K., Suga, Y., Komatsu, M., Tanaka, K., *Ikeda, S.
    • Journal Title

      Arch. Dermatol. Res.

      Volume: 307 Issue: 2 Pages: 159-169

    • DOI

      10.1007/s00403-014-1508-0

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-26000014, KAKENHI-PROJECT-26860897

  • [Journal Article] Quantitative live-cell imaging reveals spatiotemporal dynamics and cytoplasmic assembly of the 26S proteasome2014
    • Author(s)
      Pack, Chan-Gi., Yukii, H., Toh-e, A., Kudo, T., Tsuchiya, H., Kaiho, A., Sakata, E., Murata, S., Yokosawa, H., Sako, Y., Baumeister, W., Tanaka, K., and Saeki, Y
    • Journal Title

      Nat Commun.

      Volume: 5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Ubiquitin is phosphorylated by PINK1 to activate parkin.2014
    • Author(s)
      Koyano, F., Okatsu, K., Kosako, H., Tamura, Y., Go, E., Kimura, M., Kimura, Y., Tsuchiya, H., Yoshihara, H., Hirokawa, T., Endo, T., Fon. E. A., Trempe, J. F., Saeki, Y., Tanaka, K., and Matsuda, N.
    • Journal Title

      Nature

      Volume: 510(in press) Issue: 7503 Pages: 162-166

    • DOI

      10.1038/nature13392

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-23570231, KAKENHI-PLANNED-24112008, KAKENHI-PROJECT-24657072, KAKENHI-PUBLICLY-25112522, KAKENHI-PROJECT-25870311, KAKENHI-PROJECT-26000014, KAKENHI-PUBLICLY-26111729, KAKENHI-PROJECT-26440070, KAKENHI-PROJECT-26440101, KAKENHI-PROJECT-26650042, KAKENHI-PROJECT-22227003

  • [Journal Article] Ubiquitin is phosphorylated by PINK1 to activate parkin2014
    • Author(s)
      Koyano,F., Okatsu, K., Kosako, H., Tamura, Y., Go, E., Kimura, M., Kimura, Y., Tsuchiya, H., Yoshihara, H., Hirokawa, T., Endo, T., Fon. E.A., Trempe, J.F., Saeki, Y., Tanaka, K., and Matsuda, N.
    • Journal Title

      Nature

      Volume: 510 Pages: 162-166

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Proteasome dysfunction activates autophagy and the Keap1-Nrf2 pathway2014
    • Author(s)
      Kageyama S, Sou YS, Uemura T, Kametaka S, Saito T, Ishimura R, Kouno T, Bedford L, Mayer RJ, Lee MS, Yamamoto M, Waguri S, Tanaka K, and Komatsu M.
    • Journal Title

      J Biol Chem

      Volume: 289 Issue: 36 Pages: 24944-24955

    • DOI

      10.1074/jbc.m114.580357

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24249015, KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-26000014, KAKENHI-PROJECT-26253019, KAKENHI-PROJECT-26830080, KAKENHI-PROJECT-26860224

  • [Journal Article] Pba3-Pba4 heterodimer acts as a molecular matchmaker in proteasome α-ring formation2014
    • Author(s)
      Takagi, K., Saeki, Y., Yashiroda, H., Yagi, H., Kaiho, A., Murata, S., Yamane, T., Tanaka, K., Mizushima, T. and Kato, K.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 450 Issue: 2 Pages: 1110-1114

    • DOI

      10.1016/j.bbrc.2014.06.119

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PLANNED-24112008, KAKENHI-PROJECT-24570208, KAKENHI-ORGANIZER-25102001, KAKENHI-PLANNED-25102008, KAKENHI-PROJECT-25870631, KAKENHI-PROJECT-26000014, KAKENHI-PROJECT-26293018

  • [Journal Article] Tongue pressure as a novel biomarker of spinal and bulbar muscular atrophy (SBMA)2014
    • Author(s)
      Mano T, Katsuno M, Banno H, Suzuki K, Suga N, Hashizume A, Araki A, Watanabe H, Tanaka S, Yamamoto M, Sobue G
    • Journal Title

      Neurology

      Volume: 82 Issue: 3 Pages: 255-262

    • DOI

      10.1212/wnl.0000000000000041

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229011, KAKENHI-PLANNED-22110005, KAKENHI-PROJECT-23390230, KAKENHI-PROJECT-24659428

  • [Journal Article] Quantitative live-cell imaging reveals spatio-temporal dynamics and cytoplasmic assembly of the 26S proteasome2014
    • Author(s)
      Pack, CG., Yukii, H.,　Toh-e, A., Kudo, T., Tsuchiya, H., Kaiho, A., Sakata, E., Murata, S., Sako, Y., Baumeister, W., Tanaka, K., and Saeki, Y.
    • Journal Title

      Nature Commun

      Volume: 5 Issue: 1 Pages: 3396-3396

    • DOI

      10.1038/ncomms4396

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-24112008, KAKENHI-PROJECT-24657097, KAKENHI-PROJECT-25221102, KAKENHI-PROJECT-26000014

  • [Journal Article] PARK2/Parkin-mediated mitochondrial clearance contributes to proteasome activation during slow-twitch muscle atrophy via NFE2L1 nuclear translocation.2014
    • Author(s)
      Furuya N, Ikeda SI, Sato S, Soma S, Ezaki J, Trejo JA, Takeda-Ezaki M, Fujimura T, Arikawa-Hirasawa E, Tada N, Komatsu M, Tanaka K, Kominami E, Ueno T.
    • Journal Title

      Autophagy

      Volume: 10 Issue: 4 Pages: 631-41

    • DOI

      10.4161/auto.27785

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-23111003, KAKENHI-PROJECT-23592350, KAKENHI-PROJECT-24390224, KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-25350901, KAKENHI-PROJECT-25670426, KAKENHI-PROJECT-26000014

  • [Journal Article] Backbone 1H, 13C, and 15N assignments of yeast Ump1, an intrinsically disordered protein that functions as a proteasome assembly chaperone2014
    • Author(s)
      Y.Uekusa, K.Okawa, M.Yagi-Utsumi, O.Serve, Y. Nakagawa, T.Mizushima, H.Yagi, Y.Saeki, K.Tanaka, and K.Kato
    • Journal Title

      Biomol. NMR Assign.

      Volume: 8 Issue: 2 Pages: 383-386

    • DOI

      10.1007/s12104-013-9523-1

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-25102001, KAKENHI-PLANNED-25102008, KAKENHI-PROJECT-26000014

  • [Journal Article] Structural Basis for Proteasome Formation Controlled by an Assembly Chaperone Nas22014
    • Author(s)
      Satoh T, Saeki Y, Hiromoto T, Wang YH, Uekusa Y, Yagi H, Yoshihara H, Yagi-Utsumi M, Mizushima T, Tanaka K, Kato K
    • Journal Title

      Structure

      Volume: (掲載確定) Issue: 5 Pages: 731-743

    • DOI

      10.1016/j.str.2014.02.014

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-13J07852, KAKENHI-PROJECT-21000012, KAKENHI-PLANNED-24112008, KAKENHI-PROJECT-24657097, KAKENHI-PROJECT-24657113, KAKENHI-PROJECT-24770102, KAKENHI-ORGANIZER-25102001, KAKENHI-PLANNED-25102008, KAKENHI-PUBLICLY-25121730, KAKENHI-PROJECT-26000014

  • [Journal Article] Quantitative live-cell imagingreveals moleculardynamics andcytoplasmic assembly ofthe 26Sproteasome2014
    • Author(s)
      Pack, Chan-Gi., Yukii, H., Toh-e, A., Kudo,T., Tsuchiya, H., Kaiho, A., Sakata, E., Murata, S., Yokosawa, H., Sako, Y., Baumeister, W., Tanaka, K., and Saeki, Y.
    • Journal Title

      Nat Commun.

      Volume: 2014

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Translational research on disease-modifying therapies for neurodegenerative diseases2013
    • Author(s)
      Katsuno M, Watanabe H, Tanaka F, Sobue G
    • Journal Title

      Neurology and Clinical Neuroscience

      Volume: 1 Issue: 1 Pages: 3-10

    • DOI

      10.1002/ncn3.7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229011, KAKENHI-PROJECT-24659428

  • [Journal Article] Defective immune responses in mice lacking LUBAC-mediated linear ubiquitination in B cells2013
    • Author(s)
      Sasaki, Y., Sano, S., Nakahara, M., Murata, S., Kometani, K., Aiba, Y., Sakamoto, S., Watanabe, Y., Tanaka, K., Kurosaki, T., and lwai, K.
    • Journal Title

      EMBO J.

      Volume: 32 Issue: 18 Pages: 2463-2476

    • DOI

      10.1038/emboj.2013.184

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-21229007, KAKENHI-ORGANIZER-24112001, KAKENHI-PLANNED-24112002, KAKENHI-PROJECT-24659136, KAKENHI-PROJECT-25221102, KAKENHI-PROJECT-25253019

  • [Journal Article] A dimeric PINK1-containing complex on depolarized mitochondria stimulates Parkin recruitment2013
    • Author(s)
      Kei Okatsu, Midori Uno, Fumika Koyano, Etsu Go, Mayumi kimura, Toshihiko Oka, Keiji Tanaka, Noriyuki Matsuda
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 288 Issue: 51 Pages: 36372-84

    • DOI

      10.1074/jbc.m113.509653

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J06061, KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-23570232, KAKENHI-PROJECT-23687018, KAKENHI-PUBLICLY-24111557, KAKENHI-PUBLICLY-25112522

  • [Journal Article] A multi-purpose fusion tag derived from an unstructured and hyper-acidic region of the amyloid precursor protein.2013
    • Author(s)
      Sangawa, Tabata, S., Suzuki, K., Saeki, Y., Tanaka, K., and Takagi, J.
    • Journal Title

      Protein Science in press

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Aire-expressing thymic medullary epithelial cells originate from β5t-expressing progenitor cells.2013
    • Author(s)
      Ohigashi, I., Zuklys, S., Sakata, M., Mayer, GE., Zhanybekova. S., Murata, S., Tanaka, K., Hollander, G., and Takahama, Y.
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 110 Issue: 24 Pages: 9885-9890

    • DOI

      10.1073/pnas.1301799110

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-23249025, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111004, KAKENHI-PROJECT-25221102, KAKENHI-PROJECT-25860361

  • [Journal Article] The parallel reaction monitoring method contributes to highly sensitive polyubiquitin chain quantification2013
    • Author(s)
      Hikaru Tsuchiya1, Keiji Tanaka1*, and Yasushi Saeki1*
    • Journal Title

      Biochem Biophys Res Commun. in press. (*cocorespondences)

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Aire-expressing thymic medullary epithelial cells originate from β5t-expressing progenitor cells.2013
    • Author(s)
      Ohigashi, I., Zuklys, S., Sakata, M., Mayer, GE., Zhanybekova. S., Murata, S., Tanaka, K., Hollander, G., and Takahama, Y.
    • Journal Title

      Proc Natl Acad Sci USA in press.

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] A dimeric PINK1-containing complex on depolarized mitochondria stimulates Parkin recruitment2013
    • Author(s)
      OkatsuK, Uno M, Koyano F,Go E, KimuraM, Oka T,Tanaka K, Matsuda N.
    • Journal Title

      J. Biol. Chem.

      Volume: 288 Pages: 36372-36384

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Proteostasis and neurodegeneration: the roles of proteasomal degradation and autophagy.2013
    • Author(s)
      Tanaka, K., and Matsuda, N.
    • Journal Title

      Biochim. Biophys. Acta Molecular Cell Research in press

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Heat shock factor-1 influences pathological lesion distribution of polyglutamine-induced neurodegeneration2013
    • Author(s)
      Kondo N, Katsuno M, Adachi H, Minamiyama M, Doi H, Matsumoto S, Miyazaki Y, Iida M, Tohnai G, Nakatsuji H, Ishigaki S, Fujioka Y, Watanabe H, Tanaka F, Nakai A, Sobue G
    • Journal Title

      Nat Commun

      Volume: 4 Issue: 1 Pages: 1405-1405

    • DOI

      10.1038/ncomms2417

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229011, KAKENHI-PROJECT-23390230, KAKENHI-PROJECT-24659428, KAKENHI-PLANNED-22110005

  • [Journal Article] Parkin catalyzed ubiquitin-ester transfer is triggered by PINK1-dependent phosphorylation2013
    • Author(s)
      Masahiro Iguchi, Yuki Kujuro, Kei Okatsu, Fumika Koyano, Hidetaka Kosako, Mayumi Kimura, Norihiro Suzuki, Shinichiro Uchiyama, Keiji Tanaka, Noriyuki Matsuda
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 288 Issue: 30 Pages: 22019-32

    • DOI

      10.1074/jbc.m113.467530

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J06061, KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-23570231, KAKENHI-PROJECT-23687018, KAKENHI-PUBLICLY-24111557, KAKENHI-PUBLICLY-25112522, KAKENHI-PROJECT-25860721

  • [Journal Article] Proteostasis and neurodegeneration : the roles of proteasomal degradation and autophagy.2013
    • Author(s)
      Tanaka, K. and Matsuda, N.
    • Journal Title

      Biochim. Biophys. Acta (Molecular Cell Research)

      Volume: 1843 Issue: 1 Pages: 197-204

    • DOI

      10.1016/j.bbamcr.2013.03.012

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] The principal PINK1 and Parkin cellular events triggered in response to dissipation of mitochondrial membrane potential occur in primary neurons.2013
    • Author(s)
      Koyano, F., Okatsu, K., Ishigaki, S., Fujioka, Y., Kimura, M., Sobue, G., Tanaka, K.* and Matsuda, N*
    • Journal Title

      Genes Cells in press. (*cocorespondences)

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] A multi-purpose fusion tag derived from an unstructured and hyper-acidic region of the amyloid precursor protein.2013
    • Author(s)
      Sangawa, T., Tabata, S., Suzuki, K., Saeki, Y., Tanaka, K., and Takagi, J.
    • Journal Title

      Protein Science

      Volume: 22 Issue: 6 Pages: 840-850

    • DOI

      10.1002/pro.2254

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012, KAKENHI-ORGANIZER-24111001, KAKENHI-PROJECT-24651260, KAKENHI-PROJECT-24657097, KAKENHI-PLANNED-24112008

  • [Journal Article] Cytoplasmic proteasomes are not indispensable for cell growth in Saccharomyces cerevisiae2013
    • Author(s)
      Hikaru Tsuchiya1, Naoko Arai1, Keiji Tanaka1*, and Yasushi Saeki1*
    • Journal Title

      Biochem Biophys Res Commun. in press. (*cocorespondences)

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.2013
    • Author(s)
      Ichimura, Y., Waguri, S., Sou, Y., Kageyama, S., Hasegawa, J., Ishimura, R., Saito, T., Yang, Y., Kouno, T., Fukutomi, T., Hoshii, T., Atsushi, H., Takagi, K., Mizushima, T., Motohashi, H., Lee, M-S., Yoshimori, T., Tanaka, K., Yamamoto, M., and Komatsu, K.
    • Journal Title

      Mol Cell

      Volume: 51 Issue: 5 Pages: 618-631

    • DOI

      10.1016/j.molcel.2013.08.003

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21000012, KAKENHI-PLANNED-23116002, KAKENHI-PROJECT-23247034, KAKENHI-PLANNED-24112009, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24390075, KAKENHI-PROJECT-24790332, KAKENHI-PROJECT-24790967, KAKENHI-PLANNED-25111002, KAKENHI-PUBLICLY-25118710, KAKENHI-PROJECT-25460400, KAKENHI-PROJECT-25870631

  • [Journal Article] Distinct acoustic features in spinal and bulbar muscular atrophy patients with laryngospasm.2013
    • Author(s)
      Tanaka S, Banno H, Katsuno M, Suzuki K, Suga N, Hashizume A, Mano T, Araki A, Watanabe H, Adachi H, Tatsumi H, Yamamoto M, Sobue G.
    • Journal Title

      J Neurol Sci.

      Volume: 337 Issue: 1-2 Pages: 193-200

    • DOI

      10.1016/j.jns.2013.12.010

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229011, KAKENHI-PLANNED-22110005

  • [Journal Article] Spatial arrangement and functional role of α subunits of proteasome activator PA28 in hetero-oligomeric form.2013
    • Author(s)
      Sugiyama, M., Sahashi, H., Kurimoto, E., Takata, S., Yagi, H., Kanai, K., Sakata, E., Minami, Y., Tanaka, K., and Kato K.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 432 Issue: 1 Pages: 141-145

    • DOI

      10.1016/j.bbrc.2013.01.071

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-24657113, KAKENHI-PLANNED-20107004

  • [Journal Article] The proteasome : from basic mechanisms to emerging roles.2013
    • Author(s)
      Tanaka, K.
    • Journal Title

      Keio J Med.

      Volume: 62 Pages: 1-12

    • NAID

      10031160102

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] The proteasome: from basic mechanisms to emerging roles.2013
    • Author(s)
      Tanaka, K.
    • Journal Title

      Keio J. Med.

      Volume: 62 Pages: 1-12

    • NAID

      10031160102

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Involvement of Bag6 and theTRC pathwayin proteasome assembly2013
    • Author(s)
      Akahane, T., Sahara, K., Yashiroda, H., Tanaka, K., andMurata, S.
    • Journal Title

      Nat Commun.

      Volume: 4 Issue: 1 Pages: 2234-2234

    • DOI

      10.1038/ncomms3234

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-24570208, KAKENHI-PROJECT-25221102

  • [Journal Article] p62/SQSTM1 differentially removes the toxic mutant androgen receptor via autophagy and inclusion formation in a spinal and bulbar muscular atrophy mouse model2013
    • Author(s)
      Doi H, Adachi H, Katsuno M, Minamiyama M, Matsumoto S, Kondo N, Miyazaki Y, IidaM,Tohnai G, Qiang Q, Tanaka F, Yanagawa T, WarabiE,Ishii T, Sobue G
    • Journal Title

      J Neurosci

      Volume: 33 Issue: 18 Pages: 7710-7727

    • DOI

      10.1523/jneurosci.3021-12.2013

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229011, KAKENHI-PLANNED-22110005, KAKENHI-PROJECT-23390230, KAKENHI-PROJECT-23390231, KAKENHI-PROJECT-24659428, KAKENHI-PROJECT-25220103

  • [Journal Article] Parkin catalyzed ubiquitin-ester transfer is triggered by PINK1-dependent phosphorylation2013
    • Author(s)
      Iguchi, M., Kujuro, Y., Okatsu, K., Koyano, F., Kosako, H., Kimura, M., Suzuki, N., Uchiyama, S., Tanaka, K., and Matsuda, N.
    • Journal Title

      J Biol Chem

      Volume: 288 Pages: 22019-22032

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Phosphorylation ofp62 activatesthe Keap1-Nrf2 pathway duringselective autophagy2013
    • Author(s)
      Ichimura, Y., Waguri, S., Sou, Y., Kageyama, S., Hasegawa, J., Ishimura, R., Saito, T.,Yang, Y., Kouno, T., Fukutomi, T., Hoshii, T.,Atsushi, H., Takagi, K., Mizushima, T., Motohashi, H., Lee, M-S., Yoshimori, T., Tanaka, K., Yamamoto, M., and Komatsu, K.
    • Journal Title

      Mol Cell

      Volume: 51 Pages: 618-631

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Cytoplasmic proteasomes are not indispensable for cell growth in Saccharomyces cerevisiae.2013
    • Author(s)
      Tsuchiya, H., Arai, N., Tanaka, K., and Saeki, Y.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 436 Issue: 3 Pages: 372-376

    • DOI

      10.1016/j.bbrc.2013.05.105

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] The parallel reaction monitoring method contributes to highly sensitive polyubiquitin chain quantification.2013
    • Author(s)
      Tsuchiya, H., Tanaka, K., and Saeki, Y.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 436 Issue: 2 Pages: 223-229

    • DOI

      10.1016/j.bbrc.2013.05.080

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-24657097

  • [Journal Article] Endogenous nitrated nucleotide is a key mediator of autophagy and innate defense against bacteria.2013
    • Author(s)
      Ito C, Saito Y, Nozawa T, Fujii S, Sawa T, Inoue H, Matsunaga T, Khan S, Akashi S, Hashimoto R, Aikawa C, Takahashi E, Sagara H, Komatsu M, Tanaka K, Akaike T, Nakagawa I, Arimoto H.
    • Journal Title

      Mol. Cell

      Volume: 52 Issue: 6 Pages: 794-804

    • DOI

      10.1016/j.molcel.2013.10.024

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-11F01105, KAKENHI-PROJECT-12J06857, KAKENHI-ORGANIZER-20117001, KAKENHI-PLANNED-20117005, KAKENHI-PLANNED-20117006, KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-24390082, KAKENHI-PROJECT-24590527, KAKENHI-PROJECT-24790413, KAKENHI-PUBLICLY-25125708, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-25253020, KAKENHI-PROJECT-25282236, KAKENHI-PROJECT-25293370, KAKENHI-PROJECT-25305013, KAKENHI-PROJECT-25670775

  • [Journal Article] The principal PINK1 and Parkin cellular events triggered in response to dissipation of mitochondrial membrane potential also occur in primary neurons2013
    • Author(s)
      Fumika Koyano, Kei Okatsu, Shinsuke Ishigaki, Yusuke Fujioka, Mayumi Kimura, Keiji Tanaka, Noriyuki Matsuda
    • Journal Title

      Genes to Cells

      Volume: 18 Issue: 8 Pages: 672-81

    • DOI

      10.1111/gtc.12066

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J06061, KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-23687018, KAKENHI-PUBLICLY-24111557, KAKENHI-PUBLICLY-25112522

  • [Journal Article] Different dynamic movements of wild-type and pathogenic VCPs and the ir cofactors to damaged mitochondria in a Parkin-mediated mitochondrial quality control system2013
    • Author(s)
      Yoko Kimura, Junpei Fukushi, Seiji Hori, Noriyuki Matsuda, Kei Okatsu, Yukie Kakiyama, Junko Kawawaki, Akira Kakizuka, Keiji Tanaka
    • Journal Title

      Genes to Cells

      Volume: 18 Issue: 12 Pages: 1131-43

    • DOI

      10.1111/gtc.12103

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J06061, KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-23249016, KAKENHI-PROJECT-23570184

  • [Journal Article] Mitochondrial hexokinase HKI is a novel substrate of the Parkin ubiquitin ligase.2012
    • Author(s)
      Okatsu, K., Iemura, S., Koyano, F., Go, E., Kimura, M., Natsume, T., Tanaka, K., and Matsuda, N.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 428 Pages: 197-202

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Proteasomal degradation resolves competition between cell polarization and cellular wound healing.2012
    • Author(s)
      Kono, K., Saeki, Y., Yoshida, S., Tanaka, K., and Pellman, D.
    • Journal Title

      Cell

      Volume: 150 Pages: 151-164

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Thymic nurse cells do not nurse most T cells but support TCR revision in cortical thymocytes.2012
    • Author(s)
      Nakagawa, Y., Ohigashi, I., Nitta, T., Tanaka, K., Murata, S., Sakata, M., and Takahama, Y.
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 109 Pages: 20572-20577

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis.2012
    • Author(s)
      Tashiro, Y., Urushitani, M., Inoue, H., Koike, M., Uchiyama, Y., Komatsu, M., Tanaka, K., Yamazaki, M., Abe, M., Misawa. H., Sakimura, K., Ito, H., and Takahashi, R.
    • Journal Title

      J. Biol, Chem.

      Volume: 287 Pages: 42984-42994

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] β5t-containing thymoproteasome : thymic cortical epithelial cell-specific expression and role in positive selection of CD8^+ T cells2012
    • Author(s)
      Takahama, Y., Takada, K., Murata, S., Tanaka, K.
    • Journal Title

      Curr.Opini.Immunol.

      Volume: 24 Pages: 92-98

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Smad7-deficient mice show growth retardation with reduced viability2012
    • Author(s)
      Tojo M, Takebe A, Takahashi S, Tanaka K, Imamura T, Miyazono K, Chiba T
    • Journal Title

      J Biochem.

      Volume: (in press) Issue: 6 Pages: 621-631

    • DOI

      10.1093/jb/mvs022

    • NAID

      10031166104

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012, KAKENHI-PLANNED-22112002, KAKENHI-PROJECT-23570221

  • [Journal Article] Discrimination of spinal and bulbar muscular atrophy from amyotrophic lateral sclerosis using sensory nerve action potentials.2012
    • Author(s)
      Hama T, Hirayama M, Hara T, Nakamura T, Atsuta N, Banno H, Suzuki K, Katsuno M, Tanaka F, Sobue G.
    • Journal Title

      Muscle Nerve

      Volume: 45 Issue: 2 Pages: 169-174

    • DOI

      10.1002/mus.22291

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229011, KAKENHI-PROJECT-21600003, KAKENHI-PLANNED-22110005, KAKENHI-PROJECT-23390230, KAKENHI-PROJECT-23790986, KAKENHI-PROJECT-24500458

  • [Journal Article] Viral delivery of miR-196a ameliorates the SBMA phenotype via the silencing of CELF22012
    • Author(s)
      Miyazaki Y, Adachi H, Katsuno M, Minamiyama M, Jiang YM, Huang Z, Doi H, Matsumoto S, Kondo N, Iida M, Tohnai G, Tanaka F, Muramatsu S, Sobue G
    • Journal Title

      Nat Med

      Volume: 18 Issue: 7 Pages: 1136-1141

    • DOI

      10.1038/nm.2791

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229011, KAKENHI-PROJECT-23390231, KAKENHI-PROJECT-23590473, KAKENHI-PUBLICLY-23110515

  • [Journal Article] The proteasome : molecular machinery and pathophysiological roles2012
    • Author(s)
      Tanaka, K., Mizushima, T., Saeki, Y.
    • Journal Title

      Biol Chem.

      Volume: 393 Issue: 4 Pages: 217-234

    • DOI

      10.1515/hsz-2011-0285

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012, KAKENHI-PUBLICLY-23121525, KAKENHI-PROJECT-23657080

  • [Journal Article] Assembly and function of the proteasome.2012
    • Author(s)
      Saeki, Y and Tanaka, K.
    • Journal Title

      Methods Mol Biol

      Volume: 832 Pages: 315-337

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Proteasomal degradation resolves competition between cell polarization and cellular wound healing2012
    • Author(s)
      Kono, K., Saeki, Y., Yoshida, S., Tanaka, K., Pellman, D.
    • Journal Title

      Cell

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Naratriptan mitigates CGRP1-associated motor neuron degeneration caused by expanded polyglutamine2012
    • Author(s)
      Minamiyama M, Katsuno M, Adachi H, Doi H, Kondo N, Iida M, Ishigaki S, Fujioka Y, Matsumoto S, Miyazaki Y, Tanaka F, Kurihara H, Sobue G
    • Journal Title

      Nat Med

      Volume: 18 Issue: 10 Pages: 1531-1538

    • DOI

      10.1038/nm.2932

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229011, KAKENHI-PUBLICLY-23013007, KAKENHI-PROJECT-23390230, KAKENHI-PROJECT-23659107, KAKENHI-PROJECT-24249047

  • [Journal Article] Differential change of clinical outcome measures in spinal and bulbar muscular atrophy: comparison of natural history with placebo-treated group.2012
    • Author(s)
      Hashizume A, Katsuno M, Banno H, Suzuki K, Suga N, Tanaka F, Sobue G.
    • Journal Title

      J Neurol.

      Volume: 259 Issue: 4 Pages: 712-719

    • DOI

      10.1007/s00415-011-6251-2

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229011, KAKENHI-PLANNED-22110005, KAKENHI-PROJECT-23390230, KAKENHI-PROJECT-23790986

  • [Journal Article] The proteasome : from basic mechanisms to emerging roles2012
    • Author(s)
      Tanaka, K.
    • Journal Title

      Keio J.Med.

      Volume: (in press)

    • NAID

      10031160102

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Defective axonal transport in motor neuron diseases.2012
    • Author(s)
      Ikenaka K, Katsuno M, Kawai K, Ishigaki S, Tanaka F, Sobue G.
    • Journal Title

      Int J Mol Sci.

      Volume: 13 Issue: 1 Pages: 1225-1238

    • DOI

      10.3390/ijms13011225

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229011, KAKENHI-PLANNED-22110005, KAKENHI-PROJECT-23390230

  • [Journal Article] Structural basis for specific recognition of Rpt1, an ATPase subunit of the 26S proteasome, by the proteasome-dedicated chaperone Hsm32012
    • Author(s)
      Takagi, K., Kim, S., Yukii, H., Ueno, M., Morishita , R., Endo, Y., Kato, K., K., Tanaka, K., Saeki, Y., and Mizushima, Y.
    • Journal Title

      J Biol Chem.

      Volume: 287 Pages: 12172-12182

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Current status of treatment of spinal and bulbar muscular atrophy2012
    • Author(s)
      Tanaka F, Katsuno M, Banno H, Suzuki K, Adachi H, Sobue G
    • Journal Title

      Neural Plast

      Volume: 2012 Pages: 369284-369284

    • DOI

      10.1155/2012/369284

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229011, KAKENHI-PROJECT-23790986, KAKENHI-PROJECT-24659428

  • [Journal Article] Molecular pathophysiology and disease-Modifying therapies for spinal and bulbar muscular atrophy2012
    • Author(s)
      Katsuno M, Banno H, Suzuki K, Adachi H, Tanaka F, Sobue G
    • Journal Title

      Arch Neurol

      Volume: 69 Issue: 4 Pages: 436-440

    • DOI

      10.1001/archneurol.2011.2308

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229011, KAKENHI-PLANNED-22110005, KAKENHI-PROJECT-23390230, KAKENHI-PROJECT-23790986, KAKENHI-PROJECT-24659428

  • [Journal Article] Decreased proteasomal activity causes age-related phenotypes and promotes the development of metabolic abnormalities.2012
    • Author(s)
      Tomaru U, Takahashi S, Ishizu A, Miyatake Y, Gohda A, Suzuki S, Ono A, Ohara J, Baba T, Murata S, Tanaka K, and Kasahara M.
    • Journal Title

      Am. J. Pathol.

      Volume: 180 Pages: 963-972

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Cross-sectional and longitudinal analysis of an oxidative stress biomarker for spinal and bulbar muscular atrophy.2012
    • Author(s)
      Mano, T., Katsuno, M., Banno, H., Suzuki, K., Suga, N., Hashizume, A., Tanaka, F., Sobue, G.
    • Journal Title

      Muscle Nerve

      Volume: 46 Issue: 5 Pages: 692-697

    • DOI

      10.1002/mus.23413

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229011, KAKENHI-PROJECT-23390230, KAKENHI-PROJECT-23790986

  • [Journal Article] Perspectives on molecular targeted therapies and clinical trials for neurodegenerative diseases2012
    • Author(s)
      Katsuno M, Tanaka F, Sobue G
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: 83 Issue: 3 Pages: 329-335

    • DOI

      10.1136/jnnp-2011-301307

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229011, KAKENHI-PLANNED-22110005, KAKENHI-PROJECT-23390230, KAKENHI-PROJECT-24659428

  • [Journal Article] Oxidative stress induced by glutathione depletion reproduces pathological modifications of TDP-43 linked to TDP-43 proteinopathies.2012
    • Author(s)
      Iguchi Y,Katsuno M,Takagi S.Ishigaki S,Niwa JI,Hasegawa M,Tanaka F,Sobue G
    • Journal Title

      Neurobiol Dis

      Volume: 45 Issue: 3 Pages: 862-870

    • DOI

      10.1016/j.nbd.2011.12.002

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229011, KAKENHI-PLANNED-22110005, KAKENHI-PROJECT-22390175, KAKENHI-PUBLICLY-23110526, KAKENHI-PROJECT-23240050, KAKENHI-PROJECT-23659452

  • [Journal Article] Localization of the proteasomal ubiquitin receptors Rpn10 and Rpn13 by electron cryomicroscopy2012
    • Author(s)
      Sakata E, Bohn S, Mihalache O, Kiss P, Beck F, Nagy I, Nickell S, Tanaka K, Saeki Y, Förster F, and Baumeister W.
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 109 Pages: 1479-1484

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Localization of the proteasomal ubiquitin receptors Rpn10 and Rpn13 by electron cryomicroscopy2012
    • Author(s)
      Sakata E, Bohn S, Mihalache O, Kiss P, Beck F, Nagy I, Nickell S, Tanaka K, Saeki Y, Forster F, Baumeister W
    • Journal Title

      Proc Nall Acad Sci USA

      Volume: 109 Issue: 1 Pages: 1479-1484

    • DOI

      10.1073/pnas.1117648108

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Disruption of axonal transport in motor neuron diseases2012
    • Author(s)
      Ikenaka K, Katsuno M, Kawai K, Ishigaki S, Tanaka F, Sobue G
    • Journal Title

      Int J Mol Sci

      Volume: 13 Pages: 1225-1238

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229011

  • [Journal Article] Decreased proteasomal activity causes age-related phenotypes and promotes the development of metabolic abnormalities2012
    • Author(s)
      Tomaru U, Takahashi S, Ishizu A, Miyatake Y, Gohda A, Suzuki S, Ono A, Ohara J, Baba T, Murata S, Tanaka K, Kasahara M
    • Journal Title

      Am.J.Pathol.

      Volume: 180 Issue: 3 Pages: 963-972

    • DOI

      10.1016/j.ajpath.2011.11.012

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-21390112, KAKENHI-PROJECT-22590353, KAKENHI-PROJECT-23657083, KAKENHI-PROJECT-23659195, KAKENHI-PROJECT-23790430, KAKENHI-PROJECT-23790532, KAKENHI-PROJECT-24390091, KAKENHI-PROJECT-24659171

  • [Journal Article] Longitudinal changes of outcome measures in spinal and bulbar muscular atrophy.2012
    • Author(s)
      Hashizume, A., Katsuno, M., Banno, H., Suzuki, K., Suga, N., Mano, T., Atsuta, N., Oe, H., Watanabe, H., Tanaka, F., Sobue, G.
    • Journal Title

      Brain

      Volume: 35 Issue: 9 Pages: 2838-2848

    • DOI

      10.1093/brain/aws170

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229011, KAKENHI-PROJECT-23390230, KAKENHI-PROJECT-23790986

  • [Journal Article] Pathogenesis and molecular targeted therapy of spinal and bulbar muscular atrophy (SBMA).2012
    • Author(s)
      Banno, H., Katsuno, M., Suzuki, K., Tanaka, F., Sobue, G.
    • Journal Title

      Cell Tissue Res

      Volume: 349 Issue: 1 Pages: 313-320

    • DOI

      10.1007/s00441-012-1377-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229011, KAKENHI-PROJECT-23790986, KAKENHI-PROJECT-24659428

  • [Journal Article] Pathogenesis and therapy of spinal and bulbar muscular atrophy (SBMA)2012
    • Author(s)
      Katsuno M, Tanaka F, Adachi H, Banno H, Suzuki K, Watanabe H, Sobue G
    • Journal Title

      Prog Neurobiol

      Volume: 99 Issue: 3 Pages: 246-256

    • DOI

      10.1016/j.pneurobio.2012.05.007

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229011, KAKENHI-PROJECT-23390230, KAKENHI-PROJECT-23790986, KAKENHI-PROJECT-24659428

  • [Journal Article] The proteasome: molecular machinery and pathophysiological roles.2012
    • Author(s)
      Tanaka, K., Mizushima, T., and Saeki, Y.
    • Journal Title

      Biol Chem.

      Volume: 393 Pages: 217-234

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria2012
    • Author(s)
      尾勝圭
    • Journal Title

      Nature Communications

      Volume: 3 Issue: 1 Pages: 1016-1016

    • DOI

      10.1038/ncomms2016

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J06061, KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-22370042, KAKENHI-PROJECT-22370071, KAKENHI-PROJECT-23570231, KAKENHI-PROJECT-23570232, KAKENHI-PROJECT-23687018, KAKENHI-PROJECT-24657138, KAKENHI-PROJECT-24790896, KAKENHI-PLANNED-23111003, KAKENHI-PUBLICLY-23129506, KAKENHI-PUBLICLY-24111557, KAKENHI-PUBLICLY-24113717

  • [Journal Article] β5t-containing thymoproteasome: thymic cortical epithelial cell-specific expression and role in positive selection of CD8+ T cells.2012
    • Author(s)
      Takahama, Y., Takada, K., Murata, S., and Tanaka, K.
    • Journal Title

      Curr. Opini. Immunol.

      Volume: 24 Pages: 92-98

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Liver autophagy contributes to the maintenance of blood glucose and amino acid levels.2011
    • Author(s)
      Ezaki, J., Matsumoto, N., Takeda-Ezaki, M., Komatsu, M., Takahashi, K., Hiraoka, Y., Taka, H., Fujimura, T., Takehana, K., Yoshida, M., Iwata, J., Tanida, I., Furuya, N., Zheng, D-m., Tada, N., Tanaka, K., Kominami, E., Uenol, T.
    • Journal Title

      Autophagy

      Volume: (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Crystal structure of the UBA domain of p62 and its interaction with ubiquitin2011
    • Author(s)
      Isogai, S., Morimoto, D., Arita, K., Unzai, S., Tenno, T., Hasegawa, J., Sou, Y.S., Komatsu, M., Tanaka, K., Shirakawa, M., Tochio, H.
    • Journal Title

      J Biol Chem.

      Volume: 286 Issue: 36 Pages: 31864-318674

    • DOI

      10.1074/jbc.m111.259630

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012, KAKENHI-PLANNED-21121006, KAKENHI-PROJECT-21247013, KAKENHI-PUBLICLY-22113511, KAKENHI-PROJECT-22370038, KAKENHI-PROJECT-22687008, KAKENHI-PLANNED-23115004, KAKENHI-PROJECT-23570145, KAKENHI-PROJECT-23659586

  • [Journal Article] Autophagy in the intestinal epithelium reduces endotoxin-induced inflammatory responses by inhibiting NF-κB activation.2011
    • Author(s)
      Fujishima, Y., Nishiumi, S., Masuda, A., Inoue, J., Nguyen, G.M., Irino, Y., Komatsu, M., Tanaka, K., Kutsumi, H., Azuma, T., Yoshida, M.
    • Journal Title

      Arch.Biochem.Biophys.

      Volume: 506 Pages: 223-235

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] The catalytic activity of Ubp6 enhances maturation of the proteasomal regulatory particle2011
    • Author(s)
      Sakata, E., Stengel, F., Fukunaga, K., Zhou, M., Saeki, Y., Forster, F., Baumeister, W., Tanaka, K., and Robinson, CV.
    • Journal Title

      Mol. Cell

      Volume: 42 Pages: 637-649

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Ontogeny of thymic cortical epithelial cells expressing the thymoproteasome subunit beta5t2011
    • Author(s)
      Mat Ripen A
    • Journal Title

      European Journal of Immunology

      Volume: 41 Issue: 5 Pages: 1278-1287

    • DOI

      10.1002/eji.201041375

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-19059010, KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-23249025

  • [Journal Article] Sharpin is a component of the NF-κB activating linear ubiquitin chain assembly complex2011
    • Author(s)
      Tokunaga, F., Nakagawa, T., Nakahara, M., Saeki, Y., Taniguchi, M., Sakata, S., Tanaka, K., Nakano, H., Iwai, I.
    • Journal Title

      Nature

      Volume: 471 Issue: 7340 Pages: 633-636

    • DOI

      10.1038/nature09815

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012, KAKENHI-PLANNED-22117006, KAKENHI-PUBLICLY-23117717, KAKENHI-PROJECT-23657075, KAKENHI-PROJECT-23659404

  • [Journal Article] Parkin mediates apparent E2-independent monoubiquitination in vitro and contains an intrinsic activity that catalyzes polyubiquitination2011
    • Author(s)
      Chew, KCM*., Matsuda, M*., Saisho, K., Lim, GGY., Chai, C., Tan, HM., Tanaka, K., Lim, K-L.(*equally contribution)
    • Journal Title

      PloS ONE.

      Volume: 6(5) Issue: 5 Pages: e19720-e19720

    • DOI

      10.1371/journal.pone.0019720

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-23687018

  • [Journal Article] Transforming growth factor-β signaling in motor neuron diseases.2011
    • Author(s)
      Katsuno M, Adachi H, Banno H, Suzuki K, Tanaka F, Sobue G.
    • Journal Title

      Current Mol Med.

      Volume: 11 Pages: 48-56

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229011

  • [Journal Article] Role of persistent activation of Nrf2 through p62 in hepatocarcinogenesis2011
    • Author(s)
      Inami, Y., Waguri, S., Sakamoto, A., Kouno, T., Nakada, K., Hino, O., Watanabe, S., Andoh, J., Iwadate, M., Yamatmto, M., Lee. M-S., Tanaka, K., Komatsu, K.
    • Journal Title

      J.Cell.Biol.

      Volume: 193 Pages: 275-284

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Akt suppresses retrograde degeneration of dopaminergic axons by inhibition of macroautophagy2011
    • Author(s)
      Chens, H-C., Kim, SR., Oo, TF., Kareva, T., Yarygina, O., Rzhetskaya, M., Wang, C., During, M., Talloczy, Z., Tanaka, K., Komatsu, M., Kobayashi, K., Okano, H., Kholodilov, N., Burke, RE.
    • Journal Title

      J.Neurosci.

      Volume: 31 Issue: 6 Pages: 2125-2135

    • DOI

      10.1523/jneurosci.5519-10.2011

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Ontogeny of thymic cortical epithelial cells expressing thymoproteasome subunit β5t.2011
    • Author(s)
      Ripen, AM., Nitta, T., Murata, S., Tanaka, K., Takahama, Y.
    • Journal Title

      Eur.J.Immunol.

      Volume: 32 Pages: 29-40

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Role of persistent activation of Nrf2 through p62 in hepatocarcinogenesis.2011
    • Author(s)
      Inami, Y., Waguri, S., Sakamoto, A., Kouno, T., Nakada, K., Hino, O., Watanabe, S., Andoh, J., Iwadate, M., Yamamoto, M., Lee.M-S., Tanaka, K., Komatsu, K.
    • Journal Title

      J.Cell.Biol.

      Volume: 193 Pages: 275-284

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Assembly defect due to a PSMB8 mutation reduces proteasome activity and causes the autoinflammatory disorder, Nakajo-Nishimura syndrome2011
    • Author(s)
      Arima, K., Kinoshita, A., Mishima, H., Kanazawa, N., Kaneko, T., Mizushima, T., Ichinose, K., Nakamura, H., Tsujino, A., Kawakami, A., Matsunaka, M., Kasagi, S., Kawano, S., Kumagai, S., Ohmura, K., Mimori, T., Hirano, M., Ueno, S., Tanaka, K., Tanaka, M., Toyoshima, I., Sugino, H., Yamakawa, A., Tanaka, K., Niikawa, N., Furukawa, F., Murata, S., Eguchi, K., Ida, H., Yoshiura, K.
    • Journal Title

      Proc.Natl.Acad.Sci.USA

      Volume: 108 Issue: 36 Pages: 14914-14919

    • DOI

      10.1073/pnas.1106015108

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-21591097, KAKENHI-PROJECT-22591094, KAKENHI-PROJECT-22659071, KAKENHI-PROJECT-23500455, KAKENHI-PROJECT-23591651, KAKENHI-PROJECT-23657083, KAKENHI-PROJECT-23791115, KAKENHI-PROJECT-23791230

  • [Journal Article] Sharpin is a component of the NF-κB activating linear ubiquitin chain assembly complex.2011
    • Author(s)
      Tokunaga, F., Nakagawa, T., Nakaharal, M., Saeki, Y., Taniguchi, M., Sakata, S., Tanaka, K., Nakano, H., Iwai, I.
    • Journal Title

      Nature

      Volume: 471 Pages: 633-636

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Parkin Mediates Apparent E2-independent Monoubiquitination In Vitro and Contains an Intrinsic Activity that Catalyzes Polyubiquitination.2011
    • Author(s)
      Chew, KCM., Matsuda, M., Saisho, K., Lim, GGY., Chai, C., Tan, HM., Tanaka, K., Lim 1, K-L.
    • Journal Title

      PLoS ONE.

      Volume: (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] The catalytic activity of Ubp6 enhances maturation of the proteasomal regulatory particle2011
    • Author(s)
      Sakata, E., Stengel, F., Fukunaga, K., et al
    • Journal Title

      Molecular Cell

      Volume: 42 Issue: 5 Pages: 637-649

    • DOI

      10.1016/j.molcel.2011.04.021

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J06251, KAKENHI-PROJECT-20370065, KAKENHI-PROJECT-21000012

  • [Journal Article] Control of AIF-mediated cell death by antagonistic functions of CHIP ubiquitin E3 ligase and USP2 deubiquitinating enzyme.2011
    • Author(s)
      Oh, K.H., Yang, S.W., Park, J.M., Seol, J.H., Iemura, S., Natsume, T., Murata, S., Tanaka, K., Jeon, Y.J., Chung, C.H.
    • Journal Title

      Cell Death and Differ.

      Volume: (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Autophagy-deficient mice develop multiple liver tumors.2011
    • Author(s)
      Takamura, A., Komatsu, M., Hara, T., Sakamoto, A., Kishi, C., Waguri, S., Eishi, Y., Hino O., Tanaka, K., Mizushima, N.
    • Journal Title

      Genes Dev.

      Volume: 25 Pages: 795-800

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] The CD40-Autophagy Pathway Is Needed for Host Protection Despite IFN-Г-Dependent Immunity and CD40 Induces Autophagy via Control of P21 Levels.2011
    • Author(s)
      Portillo, J.A., Okenka, G., Reed, E., Subauste, A., Van, Grol, J., Gentil, K., Komatsu, M., Tanaka, K., Landreth, G., Levine, B., Subauste, C.S.
    • Journal Title

      PLoS One.

      Volume: 5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Control of AIF-mediated cell death by antagonistic functions of CHIP ubiquitin E3 ligase and USP2 deubiquitinating enzyme2011
    • Author(s)
      Oh, K.H., Yang, S.W., Park, J.M., Seol, J.H., Iemura, S., Natsume, T., Murata, S., Tanaka, K., Jeon, Y.J., Chung, C.H.
    • Journal Title

      Cell Death Differ.

      Volume: 18 Issue: 8 Pages: 1326-1336

    • DOI

      10.1038/cdd.2011.3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Liver autophagy contributes to the maintenance of blood glucose and amino acid levels2011
    • Author(s)
      Ezaki, J., Matsumoto, N., Takeda-Ezaki, M., Komatsu, M., Takahashi, K., Hiraoka, Y., Taka, H., Fujimura, T., Takehana, K., Yoshida, M., Iwata, J., Tanida, I., Furuya, N., Zheng, D-m., Tada, N., Tanaka, K., Kominami, E., Ueno, T.
    • Journal Title

      Autophagy

      Volume: 7 Issue: 7 Pages: 727-736

    • DOI

      10.4161/auto.7.7.15371

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-21570155, KAKENHI-PROJECT-22700656

  • [Journal Article] Autophagy-deficient mice develop multiple liver tumors2011
    • Author(s)
      Takamura, A., Komatsu, M., Hara, T., Sakamoto, A., Kishi, C., Waguri, S., Eishi, Y., Hino O., Tanaka, K., Mizushima, N
    • Journal Title

      Genes Dev.

      Volume: 25 Issue: 8 Pages: 795-800

    • DOI

      10.1101/gad.2016211

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-21659045

  • [Journal Article] Structure of ubiquitin-fold modifier 1 specific protease, UfSP22011
    • Author(s)
      Ha, B.H., Jeon, Y.J., Shin, S.C., Tatsumi, K., Komatsu, M., Tanaka, K., Watson, C.M., Wallis, G., Chung, C.H., Kim, E.E.
    • Journal Title

      J.Biol.Chem.

      Volume: 286 Issue: 12 Pages: 10248-10257

    • DOI

      10.1074/jbc.m110.172171

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Skp1 stabilizes the conformation of F-box proteins2011
    • Author(s)
      Yoshida, Y., Murakami, A., Tanaka, K.
    • Journal Title

      Biochem.Biophys.Res.Commun.

      Volume: 41 Issue: 1 Pages: 24-28

    • DOI

      10.1016/j.bbrc.2011.05.098

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-21580121

  • [Journal Article] A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans2011
    • Author(s)
      Kitamura A, Maekawa Y, Uehara H, Izumi K, Kawachi I, Nishizawa M, Toyoshima Y, Takahashi H, Standley DM, Tanaka K, Hamazaki J, Murata S, Obara K, Toyoshima I, Yasutomo K.
    • Journal Title

      J Clin Invest

      Volume: 121 Issue: 10 Pages: 4150-4160

    • DOI

      10.1172/jci58414

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20679005, KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-21570169, KAKENHI-PROJECT-21590536, KAKENHI-PROJECT-23591236, KAKENHI-PROJECT-23657083, KAKENHI-PROJECT-23791179

  • [Journal Article] Akt Suppresses Retrograde Degeneration of Dopaminergic Axons by Inhibition of Macroautophagy.2011
    • Author(s)
      Cheng, H-C., Kim, SR., Oo, TF., Kareva, T., Yarygina, O., Rzhetskaya, M., Wang, C., During, M., Talloczy, Z., Tanaka, K., Komatsu, M., Kobayashi, K., Okano, H., Kholodilov, N., Burke, RE.
    • Journal Title

      J.Neurosci.

      Volume: 31 Pages: 2125-2135

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Structure of ubiquitin-fold modifier 1 specific protease, UfSP2.2011
    • Author(s)
      Ha, B.H., Jeon, Y.J., Shin, S.C, Tatsumi, K., Komatsu, M., Tanaka, K., Watson, C.M., Wallis, G., Chung, C.H., Kim, E.E.
    • Journal Title

      J.Biol.Chem.

      Volume: 286 Pages: 10248-10257

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] The catalytic activity of Ubp6 enhances maturation of the proteasomal regulatory particle.2011
    • Author(s)
      Sakata, E., Stengel, F., Fukunaga, K., Zhou, M., Saeki, Y., Forster, F., Baumeister, W., Tanaka, K., Robinson, CV.
    • Journal Title

      Mol.Cell

      Volume: (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Autophagy in the intestinal epithelium reduces endotoxin-induced inflammatory responses by inhibiting NF-κB activation2011
    • Author(s)
      Fujishima, Y., Nishiumi, S., Masuda, A., Inoue, J., Nguyen, G.M., Irino, Y., Komatsu, M., Tanaka, K., Kutsumi, H., Azuma, T., Yoshida, M.
    • Journal Title

      Arch.Biochem.Biophys.

      Volume: 506 Pages: 223-235

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy.2010
    • Author(s)
      Matsuda N, Sato S, Shiba K, Okatsu K, Saisho K, Gautier CA, Sou YS, Saiki S, Kawajiri S, Sato F, Kimura M, Komatsu M, Hattori N, Tanaka K.
    • Journal Title

      J Cell Biol 189

      Pages: 211-221

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790853

  • [Journal Article] Thymoproteasome shapes immunocompetent repertoire of CD8 T cells.2010
    • Author(s)
      Nitta, T., Murata, S., Sasaki, K., Fujii, H., Ripen, A.M., Ishimaru, N., Koyasu, S., Tanaka, K., Takahama, Y.
    • Journal Title

      Immunity

      Volume: 32 Pages: 29-40

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Crystallization and preliminary X-ray characterization of Skp1-FBG3 complex.2010
    • Author(s)
      Kumanomidou, T., Nakagawa, T., Mizushima, T., Suzuki, A., Tokunaga, F., Iwai, K., Yoshida, Y., Tanaka, K., Yamane, T.
    • Journal Title

      Acta Crystallogr Sect F Struct Biol Cryst Commun.

      Volume: 66 Pages: 95-98

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Activity-based profiling reveals reactivity of the murine thymoproteasome-specific subunit beta5t.2010
    • Author(s)
      Florea, B.I., Verdoes, M., Li, N., van den Linden, W.A., Geurink, P.P., van den Elst, H., Hofmann, T., de Ru, A., van Veelen, P.A., Tanaka, K., Sasaki, K., Murata, S., den Dulk, H., Brouwer, J., Ossendorp, F.A., Kisselev, A.F., Overkleeft, H.S.
    • Journal Title

      Chem Biol.

      Volume: 17 Pages: 795-801

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.2010
    • Author(s)
      Komatsu, M., Kurokawa, H., Waguri, S., Taguchi, K., Kobayashi, A., Ichimura, Y., Sou, Y-S., Ueno, I., Sakamoto, A., Tong.K.I., Kim, M., Nishito Y., Iemura, S., Natsume, T., Ueno, T., Kominami, E., Motohashi, H., Tanaka, K., Yamamoto, M.
    • Journal Title

      Nat.Cell Biol.

      Volume: 12 Pages: 213-223

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Regulatory mechanisms involved in the control of ubiquitin homeostasis.2010
    • Author(s)
      Kimura, Y., Tanaka, K.
    • Journal Title

      J.Biochem.

      Volume: 147 Pages: 793-798

    • NAID

      10027876238

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Novel type of E3 ligase for Ufm1-conjugating system.2010
    • Author(s)
      Tatsumi, K., Sou, Y., Tada, N., Nakamura, E., Iemura, S., Natsume, T., Kang, SW., Chung, CH., Kasahara, M., Kominami, E., Tanaka, K., Komatsu, M.
    • Journal Title

      J.Biol.Chem.

      Volume: 285 Pages: 5417-5427

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Dorfin ameliorates phenotypes in a transgenic mouse model of amyotrophic lateral sclerosis2010
    • Author(s)
      Sone J, Niwa JI, Kawai K, Ishigaki S, Yamada SI, Adachi H, Katsuno M, Tanaka F, Doyu M, Sobue G.
    • Journal Title

      J Neurosci Res. 88

      Pages: 123-135

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229011

  • [Journal Article] Disrupted TGF-beta signaling in spinal and bulbar muscular atrophy2010
    • Author(s)
      Katsuno M, Adachi H, Minamiyama M, Waza M, Doi H, Kondo N, Mizoguchi H, Nitta A, Yamada K, Banno H, Suzuki K, Tanaka F, Sobue G.
    • Journal Title

      J Neurosci. 30

      Pages: 5702-5712

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229011

  • [Journal Article] Clinical features and molecular mechanisms of spinal and bulbar muscular atrophy (SBMA).2010
    • Author(s)
      Katsuno M, Banno H, Suzuki K, Adachi H, Tanaka F, Sobue G.
    • Journal Title

      Adv Exp Med Biol.

      Volume: 685 Pages: 64-74

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229011

  • [Journal Article] Ubiquitin accumulation in autophagy-deficinet mice is dependent on the Nrf2-mediated stress response pathway : a potential role for protein aggregation in autophagic substrate selection.2010
    • Author(s)
      Riley, B.E., Kaiser, S.E., Shaler, T.A., Ng, A.C.Y., Hara, T., Hipp, M.S., Lage, K., Xavier, R.J., Ryu, K-Y., Taguchi, K., Yamamoto, M., Tanaka, K., Mizushima, N., Komatsu, M., Kopito, R.R.
    • Journal Title

      J.Cell Biol.

      Volume: 191 Pages: 537-552

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] PINK1 stabilized by depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy.2010
    • Author(s)
      Matsuda, N., Sato, S., Shiba, K., Okatsu, K., Saisho, K., Gautier, CA Sou, Y., Saiki, S., Kawajiri, S., Sato, F., Kimura, M., Komatsu, M., Hattori, N., Tanaka, K.
    • Journal Title

      J Cell Biol.

      Volume: 189 Pages: 211-221

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense.2010
    • Author(s)
      Arimoto, K.I., Funami, K., Saeki, Y., Tanaka, K., Okawa, K., Takeuchi, O., Akira, S., Murakami, Y., Shimotohno, K.
    • Journal Title

      Proc.Natl.Acad.Sci.USA

      Volume: 07 Pages: 15856-15861

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria.2010
    • Author(s)
      Okatsu, K., Saisho, K., Shimanuki, M., Nakada, K., Shitara, H., Sou, Y., Kimura, M., Sato, S., Hattori, N., Komatsu, M., Tanaka.K., Matsuda, N.
    • Journal Title

      Genes Cells

      Volume: 15 Pages: 887-900

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and importance of latent 20S proteasomes in maintaining cellular homeostasis.2010
    • Author(s)
      Sasaki, K., Hamazaki, J., Koike, M., Hirano, Y., Komatsu, M., Uchiyama, Y., Tanaka, K., Murata, M.
    • Journal Title

      Mol Cell.Biol.

      Volume: 30 Pages: 3864-3874

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Disrupted transforming growth factor-beta signaling in spinal and bulbar muscular atrophy.2010
    • Author(s)
      Katsuno M, Adachi H, Minamiyama M, Waza M, Doi H, Kondo N, Mizoguchi H, Nitta A, Yamada K, Banno H, Suzuki K, Tanaka F, Sobue G
    • Journal Title

      J Neurosci

      Volume: 30 Pages: 5702-5712

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229011

  • [Journal Article] The profile of motor unit number estimation (MUNE) in spinal and bulbar muscular atrophy2010
    • Author(s)
      Suzuki K, Katsuno M, Banno H, Takeuchi Y, Kawashima M, Suga N, Hashizume A, Hama T, Uchida K, Yamashita F, Nakamura T, Hirayama M, Tanaka F, Sobue G.
    • Journal Title

      J Neurol Neurosurg Psychiatry 81

      Pages: 567-571

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229011

  • [Journal Article] Lectin-like ERAD players in ER and cytosol.2010
    • Author(s)
      Yoshida, Y., Tanaka, K.
    • Journal Title

      Biochem.Biophys.Acta

      Volume: 1800 Pages: 172-180

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] PINK1 stabilized by depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy2010
    • Author(s)
      Matsuda, N., Sato, S., Shiba, K., Okatsu, K., Saisho, K., Gautier, CA Sou, Y., Saiki, S., Kawajiri, S., Sato, F., Kimura, M., Komatsu, M., Hattori, N., and Tanaka, K.
    • Journal Title

      J Cell Biol.

      Volume: 189 Pages: 211-221

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response.2010
    • Author(s)
      Maruyama, T., Kadowaki, H., Okamoto, N., Nagai, A., Naguro, I., Matsuzawa, A., Shibuya, H., Tanaka, K., Murata, S., Takeda, K., Nishito, h H., Ichijo, H.
    • Journal Title

      EMBO J.

      Volume: 9 Pages: 2501-2514

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Does impairment of the ubiquitin-proteasome system or the autophagy-lysosome pathway predispose individuals to neurodegenerative disorders such as Parkinson's disease?2010
    • Author(s)
      Matsuda, N., Tanaka, K.
    • Journal Title

      J Alzheimer's Dis.

      Volume: 19 Pages: 1-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Dissection of the assembly pathway of the proteasome lid in Saccharomyces cerevisiae.2010
    • Author(s)
      Fukunaga, K., Kudo, T., Toh-e, A., Tanaka, K., Saeki, Y.
    • Journal Title

      Biochem.Biophys.Res.Commun.

      Volume: 396 Pages: 1048-1053

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Role of thymic cortex-specific self-peptides in positive selection of T cells.2010
    • Author(s)
      Takahama, Y., Nitta, T., Ripen, A.M., Nitta, S., Murata, M., Tanaka, K.
    • Journal Title

      Semin.Immunol.

      Volume: 22 Pages: 287-293

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Disrupted TGF-beta signaling in spinal and bulbar muscular atrophy2010
    • Author(s)
      Katsuno M, Adachi H, Minamiyama M, Waza M, Doi H, Kondo N, Mizoguchi H, Nitta A, Yamada K, Banno H, Suzuki K, Tanaka F, Sobue G
    • Journal Title

      J Neurosci

      Volume: 30 Issue: 16 Pages: 5702-5712

    • DOI

      10.1523/jneurosci.0388-10.2010

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229011

  • [Journal Article] Crystal structure of UbcH5b～ubiquitin intermediate : Insight into the formation of the self-assembled E2～Ub conjugates.2010
    • Author(s)
      Sakata, E., Satoh, T., Yamamoto, S., Yamaguchi, Y., Yagi-Utsumi, M., Kurimoto, E., Tanaka, K., Wakatsuki, S., Kato, K.
    • Journal Title

      Structure

      Volume: 18 Pages: 138-147

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Crystal structure of yeast Rpn14, a chaperone of the 19S regulatory particles of the proteasome.2010
    • Author(s)
      Kim, S., Saeki, S., Fukunaga, K., Suzuki, A., Takagi, K., Yamane, T., Tanaka, K., Mizushima, T., Kato, K.
    • Journal Title

      J.Biol.Chem.

      Volume: 285 Pages: 15159-151566

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Efficacy and safety of leuprorelin in patients with spinal and bulbar muscular atrophy (JASMITT study) : a multicentre, randomised, double-blind, placebo-controlled trial.2010
    • Author(s)
      Katsuno M, Banno H, Suzuki K, Takeuchi Y, Kawashima M, Yabe I, Sasaki H, Aoki M, Morita M, Nakano I, Kanai K, Ito S, Ishikawa K, Mizusawa H, Yamamoto T, Tsuji S, Hasegawa K, Shimohata T, Nishizawa M, Miyajima H, Kanda F, Watanabe Y, Nakashima K, Tsujino A, Yamashita T, Uchino M, Fujimoto Y, Tanaka F, Sobue Cr ; for the Japan SBMA Interventional Trial for TAP-144-SR (JASMITT) study group.
    • Journal Title

      Lancet Neurol.

      Volume: 9 Pages: 875-884

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229011

  • [Journal Article] PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy.2010
    • Author(s)
      Matsuda N, Sato S, Shiba K, Okatsu K, Saisho K, Gautier CA, Sou YS, Saiki S, Kawajiri S, Sato F, Kimura M, Komatsu M, Hattori N, Tanaka K.
    • Journal Title

      Journal of Cell Biology

      Volume: 189 Pages: 211-221

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790853

  • [Journal Article] Thymoproteasome shapes immunocompetent repertoire of CD8 T cells2010
    • Author(s)
      Nitta, T., Murata, S., Sasaki, K., Fujii, H., Ripen, A. M., Ishimaru, N., Koyasu, S., Tanaka, K., and Takahama, Y.
    • Journal Title

      Immunity

      Volume: 32 Pages: 29-40

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] The proteasome : Overview of structure and functions.2009
    • Author(s)
      Tanaka, K.
    • Journal Title

      Proc. Jpn. Acad. Ser B Phys Biol Sci. 85

      Pages: 12-36

    • NAID

      130000093918

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] Assembly pathway of the mammalian proteasome base subcomplex is mediated by multiple specific chaperones2009
    • Author(s)
      Kaneko, T., Hamazaki, J., Iemura, S., Sasaki, K., Furuyama, K., Natsume, T., Tanaka, K., and Murata, S.
    • Journal Title

      Cell

      Volume: 137 Pages: 914-925

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Autophagy regulates lipid metabolism.2009
    • Author(s)
      Singh, R., Kaushik, S., Wang, Y., Xiang, Y., Novak, I., Komatsu, M., Tanaka, K., Cuervo, AM, and Czaja, M.
    • Journal Title

      Nature 458

      Pages: 1131-1135

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] Thymic environments of T-cell repertoire formation.2009
    • Author(s)
      Nitta, T., Murata, S., Ueno, T., Tanaka, K., and Takahama, Y.
    • Journal Title

      Adv Immunol in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] Molecular mechanisms of proteasome assembly.2009
    • Author(s)
      Murata, S., Yashiroda, H., and Tanaka, K.
    • Journal Title

      Nat Rev Mol Cell Biol 10

      Pages: 104-115

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] Correlation between pyramidal tract degeneration and widespread white matter involvement in amyotrophic lateral sclerosis : a study with tractography and diffusion-tensor imaging2009
    • Author(s)
      Senda J, Ito M, Watanabe H, Atsuta N, Kawai Y, Katsuno M, Tanaka F, Naganawa S, Fukatsu H, Sobue G.
    • Journal Title

      Amyotroph Lateral Scler. 10

      Pages: 288-294

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229011

  • [Journal Article] Genetic evidence linking age-dependent attenuation of the 26S proteasome with aging process.2009
    • Author(s)
      Tonoki, A., Kuranaga, E., Tomioka, T., Hamazaki, J., Murata, S., Tanaka, K., and Miura. M.
    • Journal Title

      Mol Cell Biol. 29

      Pages: 1095-1106

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] An inhibitor of deubiquitinating enzyme regulates ubiquitin homeostasis2009
    • Author(s)
      Kimura, Y., Yashiroda, H., Kudo, T., Koitabashi, S., Murata, S., Kakizuka, A., and Tanaka, K.
    • Journal Title

      Cell

      Volume: 137 Pages: 549-559

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] Linear ubiquitination of NEMO triggers NF-κB activation.2009
    • Author(s)
      Tokunaga, T., Sakata, S., Satomi, Y., Kirisako, T., Kamei, K., Nakagawa, T., Murata, S., Yamaoka, S., Takao, T., Tanaka, K., and Iwai K.
    • Journal Title

      Nature Cell Biol. 11

      Pages: 123-132

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] The proteasome: Overview of structure and functions.2009
    • Author(s)
      Tanaka, K.
    • Journal Title

      Proc Jpn Acad Ser B85

      Pages: 12-36

    • NAID

      130000093918

    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] Multiple proteasome-interacting proteins assist the assembly of the yeast 19S regulatory particle2009
    • Author(s)
      Saeki, Y., Toh-e, A., Kudo, T., Kawamura, H., and Tanaka, K.
    • Journal Title

      Cell

      Volume: 137 Pages: 900-913

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Journal Article] An inhibitor of deubiquitinating enzyme regulates ubiquitin homeostasis.2009
    • Author(s)
      Kimura, Y., Yashiroda, H., Kudo, T., Koitabashi, S., Murata, S., Kakizuka, A., and Tanaka, K.
    • Journal Title

      Cell in press (May 1^<st>).

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] Lysine 63-linked polyubiquitin chain may serve as a targeting signal for the 26S proteasome.2009
    • Author(s)
      Saeki, Y., Kudo, T., Sone, T., Kikuchi, Y., Yokosawa, H., Toh-e, A., Tanaka, K.
    • Journal Title

      EMBO J 28

      Pages: 359-371

    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] Molecular mechanisms of proteasome assembly.2009
    • Author(s)
      Murata, S., Yashiroda, H., Tanaka, K.
    • Journal Title

      Nat Rev Mol Cell Biol 10

      Pages: 104-115

    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] The cellular pathways of neuronal autophagy and their implication in neurodegenerative diseases.2009
    • Author(s)
      Yue, Z., Friedman, L., Komatsu, M., and Tanaka, K.
    • Journal Title

      Biochem Biophys Acta - Mol Cell Res. in press.

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] TDP-43 Depletion Induces Neuronal Cell Damage through Dysregulation of Rho Family GTPases2009
    • Author(s)
      Iguchi Y, Katsuno M, Niwa J, Yamada S, Sone J, Waza M, Adachi H, Tanaka F, Nagata K, Arimura N, Watanabe T, Kaibuchi K, Sobue G.
    • Journal Title

      J Biol Chem. 284

      Pages: 22059-22066

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229011

  • [Journal Article] An inhibitor of deubiquitinating enzyme regulates ubiquitin homeostasis.2009
    • Author(s)
      Kimura, Y., Yashiroda, H., Kudo, T., Koitabashi, S., Murata, S., Kakizuka, A., Tanaka, K.
    • Journal Title

      Cell 137

      Pages: 549-559

    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] Assembly pathway of the mammalian proteasome base subcomplex is mediated by multiple specific chaperones.2009
    • Author(s)
      Kaneko, T., Hamazaki, J., Iemura, S., Sasaki, K., Furuyama, K., Natsume, T., Tanaka, K., Murata, S.
    • Journal Title

      Cell 137

      Pages: 914-925

    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] Exclusive expression of proteasome subunit β5t in the human thymic cortex.2009
    • Author(s)
      Tomaru, U., Ishizu, A., Murata, S., Miyakate, Y., Suzuki, S., Takahashi, S., Kazamaki, T., Ohara, J., Baba, T., Iwasaki, S., Fugo, K., Otsuka, N., Tanaka, K., and Kasahara, M.
    • Journal Title

      Blood in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] Heat shock proteins in neurodegenerative diseases : Pathogenic roles and therapeutic implications2009
    • Author(s)
      Adachi H, Katsuno M, Waza M, Minamiyama M, Tanaka F, Sobue G.
    • Journal Title

      Int J Hyperthermia 25

      Pages: 647-654

    • Data Source
      KAKENHI-PROJECT-21229011

  • [Journal Article] Multiple proteasome-interacting proteins assist the assembly of the yeast 19S regulatory particle.2009
    • Author(s)
      Saeki, Y., Toh-e, A., Kudo, T., Kawamura, H., Tanaka, K.
    • Journal Title

      Cell 137

      Pages: 900-913

    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] Lysine 63-linked polyubiquitin chain may serve as a targeting signal for the 26S proteasome.2009
    • Author(s)
      Saeki, Y., Kudo, T., Sone, T., Kikuchi, Y., Yokosawa, H., Toh-e, A., and Tanaka, K.
    • Journal Title

      EMBO J. 28

      Pages: 359-371

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] Mammalian 26S proteasomes remain intact during protein degradation.2008
    • Author(s)
      Kriegenburg, F., Seeger, M., Saeki, Y., Tanaka, K., Lauridsen, A-M.B., Hartmann-Petersen, R., Hendil, K.B.
    • Journal Title

      Cell 135

      Pages: 355-365

    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] Cell biology : two hands for degradation.2008
    • Author(s)
      Saeki, Y. and Tanaka, K.
    • Journal Title

      Nature (News and Views) 453

      Pages: 460-461

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice.2008
    • Author(s)
      Sou, Y., Waguri, S., Iwata, J., Ueno, T., Fujimura, T., Hara, T., Sawada, N., Yamada, A., Mizushima, N., Uchiyama, Y., Kominami, E., Tanaka, K., and Komatsu, M.
    • Journal Title

      Mol Biol Cell 19

      Pages: 4762-4775

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] Thymoproteasome: probable role in generating positively selecting peptides.2008
    • Author(s)
      Murata, S., Takahama, Y., Tanaka, K.
    • Journal Title

      Curr Opini Immunol 20

      Pages: 192-196

    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] Cell biology: two hands for degradation.2008
    • Author(s)
      Saeki, Y., Tanaka, K.
    • Journal Title

      Nature 453

      Pages: 460-461

    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] Mammalian 26S proteaspmes remain intact during protein degradation.2008
    • Author(s)
      Kriegenburg, F., Seeger, M., Saeki, Y., Tanaka, K., Lauridsen, A-M. B., Hartmann-Petersen, R., and Hendil, K. B.
    • Journal Title

      Cell 135

      Pages: 355-365

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] Crystal structure of a chaperone complex that contributes to the assembly of yeast 20S proteasomes.2008
    • Author(s)
      Yashiroda, H., Mizushima, T., Okamoto, K., Kameyama, T., Hayashi, H., Kishimoto, T., Kasahara, M., Kurimoto, E., Sakata, E., Suzuki, A., Hirano, Y., Murata, S., Kato, K., Yamane, T., Tanaka, K.
    • Journal Title

      Nat Struct Mol Biol 15

      Pages: 228-236

    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] Selective turnover of p62/a170/Sqstm1 by autophagy.2008
    • Author(s)
      Ichimura, Y., Kominami, E., Tanaka, K., and Komatsu, M.
    • Journal Title

      Autophagy 4

      Pages: 1063-1066

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] Autophagy in pancreatic beta cells is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet.2008
    • Author(s)
      Ebato, C., Uchida, T., Arakawa, M., Komatsu, M., Ueno, T., Azumal, K., Hirose, T., Tanaka, K., Kominami, E., Kawamori, R., Fujitani, Y., and Watada, H.
    • Journal Title

      Cell Metab. 8

      Pages: 325-332

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] Modest cortex and promiscuous medulla for thymic repertoire formation.2008
    • Author(s)
      Takahama, Y., Tanaka, K., and Murata, S.,
    • Journal Title

      Trends Immunol 29

      Pages: 251-155

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] c-Cbl-dependent monoubiquitination and lysosomal degradation of gp1302008
    • Author(s)
      Tanaka, Y., et. al.
    • Journal Title

      Mol.Cell.Biol 28

      Pages: 4805-4818

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] Dissecting β-ring assembly pathway of the mammalian 20S proteasome.2008
    • Author(s)
      Hirano, Y., Kaneko, T., Okamoto, K., Bai, M., Yashiroda, H., Furuyama, K., Kato, K., Tanaka, K., and Murata, S.
    • Journal Title

      EMBO J. 27

      Pages: 2204-2213

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] -ring assembly pathway of the mammalian 20S proteasome.2008
    • Author(s)
      Hirano, Y., Kaneko, T., Okamoto, K., Bai, M., Yashiroda, H., Furuyama, K., Kato, K., Tanaka, K., Murata, S.
    • Journal Title

      EMBO J 27

      Pages: 2204-2213

    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] A novel ubiquitin ligase involved in p57^<Kip2> proteolysis regulates osteoblast cell differentiation.2008
    • Author(s)
      Kim, M., Nakamoto, T., Nishimori, S., Tanaka, K., and Chiba, T.
    • Journal Title

      EMBO Rep. 9

      Pages: 878-884

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] Crystal structure of a chaperone complex that contributes to the assembly of yeast 20S proteasomes.2008
    • Author(s)
      Yashiroda, H., Mizushima, T., Okamoto, K., Kameyama, T., Hayashi, H., Kishimoto, T., Kasahara, M., Kurimoto, E., Sakata, E., Suzuki, A., Hirano. Y., Murata, S., Kato, K., Yamane, T., and Tanaka, K.
    • Journal Title

      Nature Struct. Mol. Biol. 15

      Pages: 228-236

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] Thymoproteasome : probable role in generating positively selecting peptides.2008
    • Author(s)
      Murata, S., Takahama, Y., and Tanaka, K.
    • Journal Title

      Curr Opini Immunol 20

      Pages: 192-196

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] Essential role of Macroautophagy in Pancreatic β-Cell Survival and Proliferation.2008
    • Author(s)
      Jung, HS., Chung, KW., Kim, JW., Kim, J., Komatsu, M., Tanaka, K., Nguyen, YH., Kang, TM., Jeong, YT., Han, MS., Lee, MK., Kim, KW., and Lee, MS.
    • Journal Title

      Cell Metab. 8

      Pages: 318-324

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] Unlocking the proteasome door.2007
    • Author(s)
      Saeki, Y, Tanaka, K.
    • Journal Title

      Mol Cell 27

      Pages: 865-867

    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] Regulation of CD8+ T cell development by thymus-specific proteasomes.2007
    • Author(s)
      Murata, S., Sasaki, K., Kishimoto, T., Niwa, S., Hayashi, H., Takahama, Y., Tanaka, K.
    • Journal Title

      Science 316

      Pages: 1349-1353

    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] Structural basis for selection of glycosylated substrate by SCFFbs1 ubiquitin ligase.2007
    • Author(s)
      Mizushima, T., Yoshida, Y., Kumanomidou, T., Hasegawa, Y., Suzuki, A., Yamane, T., Tanaka, K.
    • Journal Title

      Proc Natl Acad Sci USA 104

      Pages: 5777-5781

    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice.2007
    • Author(s)
      Komatsu, M., Waguri, S., Koike, M., Sou, Y., Ueno, T., Hara, T., Mizushima, N., Iwata, J., Ezaki, J., Murata, S., Hamazaki, J., Nishito, Y., Iemura, S., Natsume, N., Yanagawa, T., Uwayama, J., Warabi, E., Yoshida, H., Ishii, T., Kobayashi, A., Yamamoto, M., Yue, Z., Uchiyama, Y., Kominami, E., Tanaka, K.
    • Journal Title

      Cell 131

      Pages: 1149-1163

    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes.2006
    • Author(s)
      Hamazaki, J., Iemura, S., Natsume, T., Yashiroda, H., Tanaka, K., Murata, S.
    • Journal Title

      EMBO J. 25

      Pages: 4524-4536

    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] Cooperation of multiple chaperones required for the assembly of mammalian 20S proteasomes.2006
    • Author(s)
      Hirano, Y., Hayashi, H., Iemura, S., Hendil, K.B., Niwa, S., Kishimoto, T., Natsume, T., Kasahara, M., Tanaka, K., Murata, S.
    • Journal Title

      Mol Cell 24

      Pages: 977-984

    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] Loss of autophagy in the central nervous system causes neurodegeneration2006
    • Author(s)
      Komatsu, M., Waguri, S., Chiba, T., Murata, S., Iwata, J., Ueno, T., Koike, M., Uchiyama, Y., Kominami, E., Tanaka, K.
    • Journal Title

      Nature 441

      Pages: 880-884

    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] Loss of autophagy in the central nervous system causes neurodegeneration.2006
    • Author(s)
      Komatsu, M., Waguri, S., Chiba, T., Murata, S., Iwata, J., Ueno, T., Koike, M., Uchiyama, Y., Kominami, E., Tanaka, K.
    • Journal Title

      Nature 441

      Pages: 880-884

    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] 14-3-3h is a novel regulator of parkin ubiquitin-ligase2006
    • Author(s)
      Sato, S., Chiba, T., Sakata, E., Kato, K., Mizuno, Y., Hattori, N, Tanaka, K
    • Journal Title

      EMBO J. 25

      Pages: 211-221

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13002008

  • [Journal Article] Diverse effects of pathogenic mutations of Parkin that catalyzes multiple mono-ubiquitylation in vitro2006
    • Author(s)
      Matsuda, N., Kitami, T., Suzuki, T., Mizuno, Y., Hattori, N., Tanaka, K.
    • Journal Title

      J. Biol. Chem. 281

      Pages: 3204-3209

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13002008

  • [Journal Article] Diverse effects of pathogenic mutations of Parkin that catalyzes multiple mono-ubiquitylation in vitro2006
    • Author(s)
      Matsuda, N., Kitami, T., Suzuki, T., Mizuno, Y., Hattori, N., Tanaka, K
    • Journal Title

      J. Biol. Chem. 281

      Pages: 3204-3209

    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] 14-3-3h is a novel regulator of parkin ubiquitin-ligase2006
    • Author(s)
      Sato, S., Chiba, T., Sakata, E., Kato, K., Mizuno, Y., Hattori, N, Tanaka, K.
    • Journal Title

      EMBO J. 25

      Pages: 211-221

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13002008

  • [Journal Article] SUMO-specific protease UlpA positively regulates p53 tumor suppressor by promoting self-ubiquitination of Mdm22006
    • Author(s)
      Moon Hee Lee, M.H., Lee, E.J., Choi, S., J., Lee, S.W., Chung, S.S., Seol, J.H., Baek, S.H., Kim, K.L., Chiba, T., Tanaka, K., Bang, O.S., Chung, C.H.
    • Journal Title

      Nature Cell Biol. 8

      Pages: 1424-1431

    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] 14-3-3h is a novel regulator of parkin ubiquitin-ligase2006
    • Author(s)
      Sato, S., Chiba, T., Sakata, E., Kato, K., Mizuno, Y., Hattori, N., Tanaka, K.
    • Journal Title

      EMBO J. 25

      Pages: 211-221

    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes2006
    • Author(s)
      Hamazaki, J., Iemura, S., Natsume, T., Yashiroda, H., Tanaka, K., Murata, S.
    • Journal Title

      EMBO J. 25

      Pages: 4524-4536

    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] Cooperation of multiple chaperones required for the assembly of mammalian 20S proteasomes2006
    • Author(s)
      Hirano, Hayashi, H., Iemura, S., Hendil, K.B., Niwa, S., Kishimoto, T., Natsume, T., Kasahara, M., Tanaka, K., Murata, S.
    • Journal Title

      Mol Cell 24

      Pages: 977-984

    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] DDB2, the xeroderma pigmentosum group E gene product, is directly ubiquitylated by Cullin 4A-based ubiquitin ligase complex2005
    • Author(s)
      Matsuda, N., Azuma, K., Saijo, M., Iemura, S-I., Hioki, Y., Natsume, T., Chiba, T., Tanaka, K., Tanaka, K.
    • Journal Title

      DNA Repair 4

      Pages: 537-545

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13002008

  • [Journal Article] A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes2005
    • Author(s)
      Hirano, Y., Hendil, K.B., Yashiroda, H., Iemura, S., Nagane, R., Hioki, Y., Natsume, T., Tanaka, K., Murata, S.
    • Journal Title

      Nature 437

      Pages: 1381-1385

    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice.2005
    • Author(s)
      Komatsu, M., Waguri, S., Ueno, T., Murata, S., Tanida, I., Ezaki, E., Mizushima, N., Ohsumi, Y., Uchiyama, Y., Kominami, E., Tanaka, K., Chiba, T.
    • Journal Title

      J. Cell Biol 169

      Pages: 425-434

    • Data Source
      KAKENHI-PROJECT-17002019

  • [Journal Article] Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice2005
    • Author(s)
      Komatsu, M., Waguri, S., Ueno, T., Murata, S., Tanida, I., Ezaki, E., Mizushima, N., Ohsumi, Y., Uchiyama, Y., Kominami, E., Tanaka, K., Chiba, T.
    • Journal Title

      J. Cell Biol. 169

      Pages: 425-434

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13002008

  • [Journal Article] A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes2005
    • Author(s)
      Hirano, Y., Hendil, K.B., Yashiroda, H., Iemura, S., Nagane, R., Hioki, Y., Natsume, T., Tanaka, K., Murata, S.
    • Journal Title

      Nature 437

      Pages: 1381-1385

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13002008

  • [Journal Article] UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex.2005
    • Author(s)
      Sugasawa, K., Okuda, Y., Saijo, M., Nishi, R., Matsuda, N., Chu, G., Mori, T., Iwai, S., Tanaka, K., Hanaoka, F.
    • Journal Title

      Cell (in press)

    • Data Source
      KAKENHI-PROJECT-13002008

  • [Journal Article] Glycoprotein-specific ubiquitin-ligases recognize N-glycans in unfolded substrates2005
    • Author(s)
      Yoshida, Y., Fukiya, K., Adachi, E., Iwai, K., Tanaka, K.
    • Journal Title

      EMBO Rep. 6

      Pages: 239-244

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13002008

  • [Journal Article] Glycoprotein-specific ubiquitin-ligases recognize N-glycans in unfolded.2005
    • Author(s)
      Yoshida, Y., Fukiya, K., Adachi, E., Iwai, K., Tanaka, K.
    • Journal Title

      EMBO Rep. 6

      Pages: 239-244

    • Data Source
      KAKENHI-PROJECT-13002008

  • [Journal Article] Impairment o starvation-induced and constitutive autophagy in Atg7-deficient mice2005
    • Author(s)
      Komatsu, M., Waguri, S., Ueno, T., Murata, S., Tanida, I., Ezaki, E., Mizushima, N., Ohsumi, Y., Uchiyama, Y., Kominami, E., Tanaka, K., Chiba, T.
    • Journal Title

      J. Cell Biol. 169

      Pages: 425-434

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13002008

  • [Journal Article] A novel protein-conjugating system for Ufml, a ubiquitin-fold modifier2004
    • Author(s)
      Komatsu, M., Chiba, T., Tatsumi, K., Iemura, S., Tanida, I., Okazaki, N., Ueno, T., Kominami, E., Natsume, T., Tanaka, K.
    • Journal Title

      EMBO J. 23

      Pages: 1977-1986

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13002008

  • [Journal Article] A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier2004
    • Author(s)
      Komatsu, M., Chiba, T., Tatsumi, K., Iemura, S., Tanida, I., Okazaki, N., Ueno, T., Kominami, E., Natsume, T., Tanaka, K.
    • Journal Title

      EMBO J. 23

      Pages: 1977-1986

    • Data Source
      KAKENHI-PROJECT-13002008

  • [Journal Article] Hub1 is an essential ubiquitin-like protein without functioning as a typical modifier in fission yeast.2004
    • Author(s)
      Yashiroda, H., Tanaka, K.
    • Journal Title

      Genes to Cells 9

      Pages: 1189-1197

    • Data Source
      KAKENHI-PROJECT-13002008

  • [Journal Article] Structural basis of sugar-recognizing ubiquitin ligase2004
    • Author(s)
      Mizushima, T., Hirao, T., Yoshida, Y., Lee, S.J., Chiba, T., Iwai, K., Yamaguchi, Y., Kato, K., Tsukihara, T., Tanaka, K.
    • Journal Title

      Nature Struct.& Mol.Biol. 11

      Pages: 365-370

    • Data Source
      KAKENHI-PROJECT-13002008

  • [Journal Article] A novel protein-conjugating system for Ufml, a ubiquitin-fold modifier2004
    • Author(s)
      Komatsu, M., Chiba, T., Tatsumi, K., Iemura, S., Tanida, I., Okazaki, N., Ueno, T., Kominami, E., Natsume, T., Tanaka, K..
    • Journal Title

      EMBO J. 23

      Pages: 1977-1986

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13002008

  • [Journal Article] Hubl is an essential ubiquitin-like protein without functioning as a typical modifier in fission yeast2004
    • Author(s)
      Yashiroda, H., Tanaka, K.
    • Journal Title

      Genes Cells 9

      Pages: 1189-1197

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13002008

  • [Journal Article] Structural basis of sugar-recognizing ubiquitin ligase2004
    • Author(s)
      Mizushima, T., Hirao, T., Yoshida, Y., Lee, S.J., Chiba, T., Iwai, K., Yamaguchi, Y., Kato, K., Tsukihara, T., Tanaka, K.
    • Journal Title

      Nature Struct. Mol. Biol. 11

      Pages: 365-370

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13002008

  • [Journal Article] The molecular chaperone Hsp90 interacts with 26S proteasomes and regulates their a ssembly2003
    • Author(s)
      Imai, J., Maruya, M., Yashiroda, H., Yahara, I., Tanaka, K.
    • Journal Title

      EMBO J. 22

      Pages: 3557-3567

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13002008

  • [Journal Article] The molecular chaperone Hsp90 interacts with 26S proteasomes and regulates their assembly2003
    • Author(s)
      Imai, J., Maruya, M., Yashiroda, H., Yahara, I., Tanaka, K.
    • Journal Title

      EMBO J. 22

      Pages: 3557-3567

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13002008

  • [Journal Article] Parkin binds the Rpn10 subunit of 26S proteasomes with the ubiquitin-like domain2003
    • Author(s)
      Sakata, E., Yamaguchi, Y., Kurimoto, E., Kikuchi, J., Yokoyama, S., Yamada, S., Kawahara, H., Yokosawa, H., Hattori, N., Mizuno, Y., Tanaka, K., Kato, K.
    • Journal Title

      EMBO Rep. 4

      Pages: 301-306

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13002008

  • [Journal Article] Parkin binds the Rpn10 subunit of 26S proteasomes with the ubiquitin-like domain2003
    • Author(s)
      Sakata, E., Yamaguchi, Y., Kurimoto, E., Kikuchi, J., Yokoyama, S., Yamada, S., Kawahara, H., Yokosawa, H., Hattori, N.Mizuno, Y., Tanaka, K., Kato, K.
    • Journal Title

      EMBO Rep 4

      Pages: 301-306

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13002008

  • [Journal Article] Conditional knockdown of proteasomes results in cell-cycle arrest and enhanced expression of molecular chaperones Hsp70 and Hsp40 in chicken DT40 cells2003
    • Author(s)
      Tanahashi-Hori, T., Tanahashi, N., Tanaka, K., Chiba, T.
    • Journal Title

      J. Biol. Chem. 278

      Pages: 16237-16243

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13002008

  • [Journal Article] Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains2003
    • Author(s)
      Yoshida, Y., Tokunaga, F., Chiba, T., Iwai, K., Tanaka, K., Tai, T.
    • Journal Title

      J. Biol. Chem. 278

      Pages: 43877-43884

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13002008

  • [Journal Article] Two distinct pathways mediated by PA28 and hsp90 in MHC class I antigen processing2002
    • Author(s)
      Yamano, T., Murata, S., Shimbara, N., Tanaka, N., Chiba, T., Tanaka, K., Yui, K., Udono, H.
    • Journal Title

      J. Exp. Med. 196

      Pages: 185-196

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13002008

  • [Journal Article] The structure of the mammalian 20S proteasome at 2.75Å resolution2002
    • Author(s)
      Unno, M., Mizushima, T., Morimoto, Y., Tomisugi, Y., Tanaka, K., Yasuoka, N., Tsukihara, T.
    • Journal Title

      Structure 10

      Pages: 609-618

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13002008

  • [Journal Article] 26S proteasomes function as stable entities2002
    • Author(s)
      Hendil, K.B., Hartmann-Petersen, R., Tanaka.K.
    • Journal Title

      J. Mol. Biol. 315

      Pages: 627-636

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13002008

  • [Journal Article] E3 ubiquitin-ligase that recognizes sugar chains2002
    • Author(s)
      Yoshida, Y., Chiba, T., Tokunaga, T., Kawasaki, H., Iwai, K., Suzuki, T., Ito, Y., Matsuoka, K., Yoshida, M., Tanaka, K., Tai, T.
    • Journal Title

      Nature 418

      Pages: 438-442

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13002008

  • [Journal Article] The structure of the mammalian 20S proteasome at 2.75 Å resolution2002
    • Author(s)
      Unno, M., Mizushima, T., Morimoto, Y., Tomisugi, Y., Tanaka, K., Yasuoka, N., Tsukihara, T.
    • Journal Title

      Structure 10

      Pages: 609-618

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13002008

  • [Journal Article] Two distinct pathways mediated by PA28 and hsp90 in MHC class I antigen processing2002
    • Author(s)
      Yamano, T., Murata, S., Shimbara, N., Tanaka, N., Chiba, T., Tanaka, K.Yui, K., Udono, H.
    • Journal Title

      J. Exp. Med. 196

      Pages: 185-196

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13002008

  • [Journal Article] 26S proteasomes function as stable entities2002
    • Author(s)
      Hendil, K.B., Hartmann-Petersen, R., Tanaka, K.
    • Journal Title

      J. Mol. Biol. 315

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13002008

  • [Journal Article] CHIP is a chaperone-dependent E3 ligase that ubiquitylates unfolded protein2001
    • Author(s)
      Murata, S., Minami, Y., Minami, M., Chiba, T., Tanaka, K
    • Journal Title

      EMBO Rep. 2

      Pages: 1133-1138

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13002008

  • [Journal Article] NEDD8 recruits E2-ubiquitin to SCF E3-ligase2001
    • Author(s)
      Kawakami, T., Chiba, T., Suzuki, T., Iwai, K., Yamanaka, K., Minato, N., Hidaka, Y., Shimbara, N., Suzuki, H., Osak, F., Omata, M., Tanaka, K
    • Journal Title

      EMBO J. 20

      Pages: 4003-4012

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13002008

  • [Journal Article] Immunoproteasome assembly and antigen processing in mice lacking both PA28a and PA28b.2001
    • Author(s)
      Murata, S., Udono, H., Tanahashi, N., Hamada, N., Adachi, K., Yamano, T., Yui, K., Kobayashi, N., Kawahara, M., Tanaka, K., Chiba, T.
    • Journal Title

      EMBO J. 20

      Pages: 5898-5907

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13002008

  • [Journal Article] NEDD8 recruits E2-ubiquitin to SCF E3-ligase2001
    • Author(s)
      Kawakami, T., Chiba, T., Suzuki, T., Iwai, K., Yamanaka, K., Minato, N., Hidaka, Y., Shimbara, N., Suzuki, H., Osak, F., Omata, M., Tanaka, K.
    • Journal Title

      EMBO J. 20

      Pages: 4003-4012

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13002008

  • [Journal Article] Immunoproteasome assembly and antigen processing in mice lacking both PA28a and PA28b2001
    • Author(s)
      Murata, S., Udono, H., Tanahashi, N., Hamada, N., Adachi, K., Yamano, T., Yui, K., Kobayashi, N., Kasahara, M., Tanaka, K., Chiba, T.
    • Journal Title

      EMBO J 20

      Pages: 5898-5907

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13002008

  • [Journal Article] The NEDD8 system is essential for cell cycle progression and morphogenetic pathway in mice2001
    • Author(s)
      Tateishi, K., Omata, M., Tanaka, K., Chiba, T.
    • Journal Title

      J. Cell Biol. 155

      Pages: 571-580

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13002008

  • [Journal Article] CHIP is a chaperone- dependent E3 ligase that ubiquitylates unfolded protein2001
    • Author(s)
      Murata, S., Minami, Y., Minami, M., Chiba, T., Tanaka, K.
    • Journal Title

      EMBO Rep. 2

      Pages: 1133-1138

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13002008

  • [Journal Article] Impariment of starvation-induced and constitutive autophagy in Atg7-deficient mice.
    • Author(s)
      Komatsu, M., Waguri, S., Ueno, T., Murata, S., Tanida, I., Ezaki, E., Mizushima, N., Ohsumi, Y., Uchiyama, Y., Kominami, E., Tanaka, K.K., Chiba, T.
    • Journal Title

      J.Cell Biol. (In press)

    • Data Source
      KAKENHI-PROJECT-13002008

  • [Journal Article] Loss of autophagy in the central nervous system causes neurodegeneration
    • Author(s)
      Komatsu, M., Waguri, S., Chiba, T., Murata, S., Iwata, J., Ueno, T., Koike, M., Uchiyama, Y., Kominami, E., Tanaka, K.
    • Journal Title

      Nature (in press)(Published online 19 April 2006, doi:10.1038/ nature 04723).

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13002008

  • [Journal Article] Loss of autophagy in the central nervous system causes neurodegeneration
    • Author(s)
      Komatsu, M., Waguri, S., Chiba, T., Murata, S., Iwata, J., Ueno, T., Koike, M., Uchiyama, Y., Kominami, E., Tanaka, K
    • Journal Title

      Nature (Published online 19 April 2006, doi : 10.1038/nature 04723). (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13002008

  • [Patent] ポリユビキチン化基質の同定方法2014
    • Inventor(s)
      吉田雪子、佐伯泰、土屋光、村上有沙、田中啓二
    • Industrial Property Rights Holder
      (公財)東京都医学総合研究所
    • Filing Date
      2014-11-13
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Patent] A novel versatile method for determining ubiuuitin chain length reveals functional units of polyyubiguitin chains in cells2013
    • Inventor(s)
      佐伯 泰, 土屋 光, 海保 愛, 田中啓二
    • Industrial Property Rights Holder
      (公財)東京都医学総合研究所
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-11-08
    • Overseas
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Patent] A novel versatile method for determining ubiquitin chain length reveals functional units of polyyubiquitin chains in cells2013
    • Inventor(s)
      佐伯泰、土屋光、海保愛、田中啓二
    • Industrial Property Rights Holder
      (公財)東京都医学総合研究所
    • Filing Date
      2013-11-08
    • Overseas
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Patent] ポリユビキチン化基質の同定方法2013
    • Inventor(s)
      吉田雪子, 佐伯 泰, 土屋 光, 村上有沙, 田中啓二
    • Industrial Property Rights Holder
      (公財)東京都医学総合研究所
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-11-15
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Patent] ポリユビキチン化基質の同定方法2013
    • Inventor(s)
      吉田雪子、佐伯泰、土屋光、村上有沙、田中啓二
    • Industrial Property Rights Holder
      (公財)東京都医学総合研究所
    • Filing Date
      2013-11-15
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Patent] 条件的自食作用欠損動物及び疾患モデル動物2011
    • Inventor(s)
      田中啓二、千葉智樹、小松雅明
    • Industrial Property Rights Holder
      (公財)東京都医学総合研究所
    • Acquisition Date
      2011-05-27
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Patent] 肝疾患治療薬2011
    • Inventor(s)
      田中啓二、小松雅明、丹羽眞一郎、牧野泰孝、笠間隆志
    • Industrial Property Rights Holder
      (公財)東京都医学総合研究所
    • Filing Date
      2011-07-14
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Patent] 条件的自食作用欠損動物及び疾患モデル動物2003
    • Inventor(s)
      田中啓二, 千葉智樹, 小松雅明
    • Industrial Property Rights Holder
      (財)東京都医学研究機構
    • Filing Date
      2003-06-20
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13002008

  • [Presentation] Proteo- and Organello-stasis Linked to Neurodegeneration2022
    • Author(s)
      Keiji TANAKA
    • Organizer
      JSN 63rd Annual Meeting Commemorative Lecture
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H00997

  • [Presentation] 私のプロテアソーム研究 ～温故知新～2022
    • Author(s)
      田中啓二
    • Organizer
      先端モデル動物支援プラットフォーム (AdAMS) 成果発表会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H00997

  • [Presentation] Autophagy and Nutrition2022
    • Author(s)
      Keiji TANAKA
    • Organizer
      The 8th Asian Congress of Dietetics
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H00997

  • [Presentation] 基礎研究余話「役に立たない研究」と「役に立つ研究」2022
    • Author(s)
      田中啓二
    • Organizer
      日本学術会議主催学術フォーラム 国際基礎科学年（IYBSSD2022） ～持続可能な世界のために
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H00997

  • [Presentation] プロテアソームの基礎から医学研究へ2022
    • Author(s)
      田中啓二
    • Organizer
      日本臨床ストレス応答学会 第16回大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H00997

  • [Presentation] オートファジーと栄養2022
    • Author(s)
      田中啓二
    • Organizer
      第39回日本微量栄養素学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H00997

  • [Presentation] プロテアソーム ～基礎から医学研究へ～2021
    • Author(s)
      田中啓二
    • Organizer
      星薬科大学 先端生命科学研究所 Webシンポジウム「新しい薬のモダリティ」
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H00997

  • [Presentation] プロテアソーム ～基礎から医学研究へ～2021
    • Author(s)
      田中啓二
    • Organizer
      第101回 北海道医学大会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H00997

  • [Presentation] プロテアソーム ～基礎から最先端研究へ～2021
    • Author(s)
      田中啓二
    • Organizer
      第3回 ヒトレトロウイルス学共同研究セミナー
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H00997

  • [Presentation] プロテアソーム ～ 基礎から最先端研究へ ～2020
    • Author(s)
      田中啓二
    • Organizer
      第29回泌尿器科分子・細胞研究会：未知との遭遇～基礎研究は楽しい～ イブニングセミナー2
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H00997

  • [Presentation] プロテアソーム ～ 基礎から医学応用へ ～2020
    • Author(s)
      田中啓二
    • Organizer
      第24回日本がん分子標的治療学会（基調講演 1）
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H00997

  • [Presentation] プロテアソーム ～選択的なタンパク質リサイクルシステム～2020
    • Author(s)
      田中啓二
    • Organizer
      第13回オートファジー研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H00997

  • [Presentation] タンパク質分解：プロテアソームとオートファジー2020
    • Author(s)
      田中啓二
    • Organizer
      第24回日本肝臓学会大会：特別講演
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H00997

  • [Presentation] Phase Separated Proteasome Condensates: For Nuclear Proteolysis.2019
    • Author(s)
      Keiji Tanaka
    • Organizer
      Joint Annual Meeting of 71st JSCB & 19th PSSJ, Joint Symposium. Emerging concepts of protein science: From nanoscale to cells
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H00997

  • [Presentation] 蛋白質科学の新常識 : ナノスケールから細胞まで2019
    • Author(s)
      S. Yasuda, H. Tsuchiya, Y. Saeki, and K. Tanaka
    • Organizer
      第19回日本蛋白質科学会年会・第71回日本細胞生物学会大会、合同企画シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] Phase Separated Proteasome Condensates : For Nuclear Proteolysis2019
    • Author(s)
      Keiji Tanaka
    • Organizer
      Joint Annual Meeting of 71st JSCB & 19th PSSJ, Joint Symposium. Emerging concepts of protein science : From nanoscale to cells
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] プロテアソーム～相分離が拓く新しいタンパク質分解機構～2019
    • Author(s)
      田中啓二
    • Organizer
      第二回 形態解析ワークショップー 多様な顕微鏡を用いて
    • Invited
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] 細胞内恒常性機能維持機構とがん・老化関連疾患. 「肺線維症における細胞老化の意義と治療的応用」2019
    • Author(s)
      田中啓二
    • Organizer
      第4回 肺トランスレーショナルメデイシン研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] The Proteasome - Action Mechanisms and Spatiotemporal Dynamics2019
    • Author(s)
      Keiji Tanaka
    • Organizer
      Ken-ichi Arai Memorial Symposium
    • Invited
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] プロテアソーム～ 相分離が拓く新しいタンパク質分解機構 ～2019
    • Author(s)
      田中啓二
    • Organizer
      第二回　形態解析ワークショップ － 多様な顕微鏡を用いて
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H00997

  • [Presentation] The Proteasome : Stress and Phase Separation2019
    • Author(s)
      Keiji Tanaka
    • Organizer
      NIH-Japan-JSPS Symposium: Symposium
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H00997

  • [Presentation] 細胞内恒常性機能維持機とがん・老化関連疾患.2019
    • Author(s)
      田中啓二
    • Organizer
      第4回 肺トランスレーショナルメデイシン研究会「肺線維症における細胞老化の意義と治療的応用」
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H00997

  • [Presentation] The Proteasome　～ Action Mechanisms and Spatiotemporal Dynamics ～2019
    • Author(s)
      Keiji Tanaka
    • Organizer
      Ken-ichi Arai Memorial Symposium
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H00997

  • [Presentation] The Proteasome : Stress and Phase Separation2019
    • Author(s)
      Keiji Tanaka
    • Organizer
      NIH-Japan-JSPS Symposium : Symposium Theme : Inflammation
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] これから科学者を目指す君たちへ2018
    • Author(s)
      田中啓二
    • Organizer
      秋田大学市民講演会
    • Invited
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] ユビキチンとプロテアソーム～基礎から医学研究へ～.2018
    • Author(s)
      田中啓二
    • Organizer
      国立国際医療研究センター研究所(NCGMRI)“冬期リトリート”
    • Invited
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] The Proteasome～Structure and Immunological Roles～2018
    • Author(s)
      Keiji Tanaka
    • Organizer
      The XVI International Symposium on Amyloidosis (ISA2018)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] Spatio-temporal Dynamics of Human Proteasomes in Stress Responses2018
    • Author(s)
      Keiji Tanaka
    • Organizer
      The 8th Proteasome and Autophagy Workshop
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] Assembly and Spatio-temporal Dynamics2018
    • Author(s)
      Keiji Tanaka
    • Organizer
      24th IUBMB-15th FAOBMB Congress, N. Protein modification and regulation (4) [SY1-1] PTM in Cell Signaling
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] プロテアソーム～動作原理から生理機能～2018
    • Author(s)
      田中啓二
    • Organizer
      新潟大学 医学部 セミナー
    • Invited
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] プロテアソーム ～四半世紀の研究を回想する～2018
    • Author(s)
      田中啓二
    • Organizer
      徳島大学 先端酵素学研究所設立記念シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] The Proteasome ～Action Mechanisms and Physiology～2018
    • Author(s)
      Keiji Tanaka
    • Organizer
      Advanced Forum on Protein Sciences in Beijing
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] Parkin - Overview.2018
    • Author(s)
      Keiji Tanaka
    • Organizer
      The 41st Annual Meeting of the Japan Neuroscience Society on New Horizon of Neuroscience, “Parkin” 20th anniversary International symposium
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] The Proteasome ～Structure and Spatiotemporal Dynamics～2018
    • Author(s)
      Keiji Tanaka
    • Organizer
      Asian Pacific Prion Symposium 2018 (APPS2018)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] プロテアソーム～選択的なタンパク質リサイクルシステム～2018
    • Author(s)
      田中啓二
    • Organizer
      自治医科大学大学院医学研究科 開設40周年記念事業
    • Invited
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] The Proteasome ～Assembly and Spatiotemporal Dynamics～2018
    • Author(s)
      Keiji Tanaka
    • Organizer
      International Symposium on “Proteins : from the Cradle to the Grave”
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] Cell-mediated Immunity govern by Immunoproteasome and Thymoproteasome, “Ubiquitin Family, Autophagy and Diseases”2018
    • Author(s)
      Keiji Tanaka
    • Organizer
      Cold Spring Harbor Asia Conference (CSH Asia)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] プロテアソーム～もう一つのタンパク質リサイクルシステム2017
    • Author(s)
      田中啓二
    • Organizer
      ～東工大栄誉教授・大隅良典氏 ノーベル賞受賞記念「七人の侍」講演会
    • Invited
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] タンパク質分解と生命医科学研究2017
    • Author(s)
      田中啓二
    • Organizer
      平成28年度 東京都医師会功労賞表彰式および医学研究賞・グループ研究賞受賞記念講演会
    • Place of Presentation
      東京都医師会館(東京都千代田区)
    • Year and Date
      2017-02-25
    • Invited
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] プロテアソームを手探りに免疫の世界を楽しむ2017
    • Author(s)
      田中啓二
    • Organizer
      第19回免疫サマースクール in 湘南
    • Invited
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] タンパク質リサイクルシステム～プロテアソーム と オートファジー2017
    • Author(s)
      田中啓二
    • Organizer
      ～ライフサイエンス イノベーション発信セミナー
    • Invited
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] Emerging Role of Thymoproteasomes in (Adaptive) Immunity.2017
    • Author(s)
      Keiji Tanaka
    • Organizer
      Sorak Conference on Protein Metabolism and Degradation
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] 私のプロテアソーム研究 ～幸運と不運の間で～2017
    • Author(s)
      田中啓二
    • Organizer
      第44回神戸ラボ全体研究会議
    • Invited
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] The Proteasome : Overview of the Structure and Functions2017
    • Author(s)
      田中啓二
    • Organizer
      ConBio2017 Consortium of Biological Sciences 2017
    • Invited
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] プロテアソーム と オートファジー2017
    • Author(s)
      田中啓二
    • Organizer
      第22回日本病態プロテアーゼ学会学術集会 教育講演
    • Invited
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] 細胞内リサイクルシステム～ プロテアソーム と オートファジー2017
    • Author(s)
      田中啓二
    • Organizer
      ～製薬コンソ・AMED共催 創薬コンソ分野別研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] プロテアソーム ～基礎研究が未来を拓く～2017
    • Author(s)
      田中啓二
    • Organizer
      第1回日本医療研究開発大賞 受賞記念講演
    • Invited
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] プロテアソームと適応(細胞性)免疫2017
    • Author(s)
      田中啓二
    • Organizer
      第14回Osteoimmunology Forum
    • Place of Presentation
      ステーションコンファレンス東京(東京都千代田区)
    • Year and Date
      2017-02-11
    • Invited
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] 免疫型プロテアソームによる Antigen processingと“自己と非自己の識別”機構2016
    • Author(s)
      田中啓二
    • Organizer
      第25回日本組織適合性学会 : MHC研究の進歩 : 生命科学と臨床医学へのインパクト
    • Place of Presentation
      北海道大学学術交流会館(北海道札幌市)
    • Year and Date
      2016-10-22
    • Invited
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] Ubiquitin chain-type selectivity of ubiquitin-binding proteins in yeast2016
    • Author(s)
      Keiji Tanaka
    • Organizer
      Ubiquitin Family, Autophagy and Diseases Cold Spring Harbor Asia Conference (CSH Asia)
    • Place of Presentation
      Suzhou, China
    • Year and Date
      2016-04-18
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] 研究と教育～組織改革への期待～2016
    • Author(s)
      田中啓二
    • Organizer
      「変わる徳島大学」学部新設・改組及び新研究所設置記念式典・記念講演会
    • Place of Presentation
      徳島グランヴィリオホテル・グランヴィリオホール(徳島県徳島市)
    • Year and Date
      2016-04-11
    • Invited
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] Spatio-temporal Dynamics of the Human Proteasome in Stress Responses2016
    • Author(s)
      Keiji Tanaka
    • Organizer
      FASEB “Ubiquitin & Cellular Regulation”
    • Place of Presentation
      Big Sky Resort Huntley Lodge 50 Big Sky Resort Road Big Sky MT, USA
    • Year and Date
      2016-06-12
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] 半端なベクトルに出口無し!～徹底した基礎研究から広がる応用～「黎明期のプロテアソーム研究」2016
    • Author(s)
      田中啓二
    • Organizer
      第39回分子生物学会(MBSJ)年会 プレナリーモーニングセミナー
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-12-02
    • Invited
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] ～タンパク質のゆりかごから墓場まで～「プロテアソーム“自己と非自己”識別の根源に迫る!」2016
    • Author(s)
      田中啓二
    • Organizer
      京都産業大学「タンパク質動態研究所」開設記念シンポジウム
    • Place of Presentation
      京都産業大学講堂(京都府京都市)
    • Year and Date
      2016-10-26
    • Invited
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] Thymoproteasome : The Key Player in Positive Selection of CD8+ T cells2016
    • Author(s)
      Keiji Tanaka
    • Organizer
      The 7th Proteasome and Autophagy Workshop
    • Place of Presentation
      Clermont-Ferrand, France
    • Year and Date
      2016-04-06
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] “変わる徳島大学” : 「研究と教育 ～組織改革への期待～」2016
    • Author(s)
      田中啓二
    • Organizer
      学部新設・改組及び新研究所設置記念式典・記念講演会
    • Place of Presentation
      徳島グランヴィリオホール(徳島県徳島市)
    • Year and Date
      2016-04-11
    • Invited
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] 私のブロテアソーム研究～幸運と不運に彩られて～2016
    • Author(s)
      田中啓二
    • Organizer
      第121回日本解剖学会総会・全国学術集会
    • Place of Presentation
      ビッグパレットふくしま(福島県郡山市)
    • Year and Date
      2016-03-28
    • Invited
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] Ubiquitin Chain-type. 「Selectivity of Ubiquitin-binding Proteins in Yeast」2016
    • Author(s)
      Keiji Tanaka
    • Organizer
      Ubiquitin Family, Autophagy and Disease. Cold Spring Harbor Asia Conference (CSH Asia)
    • Place of Presentation
      Suzhou, China
    • Year and Date
      2016-04-18
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] 私のプロテアソーム研究2016
    • Author(s)
      田中啓二
    • Organizer
      89回 日本生化学会大会 ～生化学の創造的復興～ Meet the Expert.
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-09-27
    • Invited
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] タンパク質分解～辺境領域から生命科学の中枢へ～2015
    • Author(s)
      田中啓二
    • Organizer
      第8回「酵素学研究拠点」シンポジウム : タンパク質代謝・分解系の酵素学「文化功労者」顕彰記念講演
    • Place of Presentation
      徳島大学藤井節郎記念ホール、徳島県徳島市
    • Year and Date
      2015-02-10
    • Invited
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] タンパク質分解～辺境領域から生命科学の中枢へ～2015
    • Author(s)
      田中啓二
    • Organizer
      国立医薬品食品衛生研究所 講演
    • Place of Presentation
      国立医薬品食品衛生研究所(東京都世田谷区)
    • Year and Date
      2015-09-04
    • Invited
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] Basic Mechanisms and Physiopathology of The Proteasome2015
    • Author(s)
      Keiji Tanaka
    • Organizer
      IMP (Research Institute of Molecular Pathology) Lecture
    • Place of Presentation
      Vienna Biocenter, Austria
    • Year and Date
      2015-07-09
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] 栄養学における基礎科学と応用科学の統合2015
    • Author(s)
      田中啓二
    • Organizer
      日本栄養士会・研究教育事業部・全国研修会の基調講演
    • Place of Presentation
      東京農業大学、東京都世田谷区
    • Year and Date
      2015-03-07
    • Invited
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] In-depth Analyses of Thymoproteasomes -Positive Selection of CD8+ T cells-2015
    • Author(s)
      Keiji Tanaka
    • Organizer
      Ubiquitin and Ubiquitin-like modifiers : From molecular mechanisms and human diseases (2nd EMBO Ubiquitin Conference Series)
    • Place of Presentation
      I Cavtat, Croatia
    • Year and Date
      2015-09-18
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] Ubiquitin : lst Mitophagy driven by PINKI, Parkin and Ubiquitin, 2nd MS and TR-Tube Strategy for Ubiquitin Code Analysis2015
    • Author(s)
      Keiji Tanaka
    • Organizer
      The 2nd Ubiquitin Symposium at Hotel Stefani e
    • Place of Presentation
      Vienna Biocenter, Austria
    • Year and Date
      2015-07-10
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] 「細胞内の蛋白質の一生 : 新生から死に至るまで」 : タンバク質分解装置“ブロテアソーム”の動態と作動機構2015
    • Author(s)
      田中啓二
    • Organizer
      第15回 日本蛋白質科学会 年会シンポジウム
    • Place of Presentation
      あわぎんホール(徳島県徳島市)
    • Year and Date
      2015-06-24
    • Invited
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] 栄養学における基礎科学と応用科学の統合2015
    • Author(s)
      田中啓二
    • Organizer
      徳島大学栄養学科同窓会(栄友会)東日本支部(文化功労者顕彰記念)同窓会セミナー
    • Place of Presentation
      昭和女子大学(東京都世田谷区)
    • Year and Date
      2015-06-27
    • Invited
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] 生化学の立場から～タンパク質の新陳代謝～2014
    • Author(s)
      田中啓二
    • Organizer
      第61回日本栄養改善学会学術集会「栄養学-新たな挑戦日本栄養改善学会60周年シンポジウム」
    • Place of Presentation
      パシフィコ横浜、神奈川県横浜市
    • Year and Date
      2014-08-21
    • Invited
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] プロテアソーム : 動作原理から炎症免疫疾患制御への展望2014
    • Author(s)
      田中啓二
    • Organizer
      第35回日本炎症・再生医学会 : 教育講演
    • Place of Presentation
      万国津梁館、沖縄(発表確定)
    • Invited
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Presentation] 私のプロテアソーム研究を回想して…2014
    • Author(s)
      田中啓二
    • Organizer
      第66回細胞生物学会大会 S11 七人の侍からのメッセージ～私の仕事を通じて若者達に伝えたきこと～
    • Place of Presentation
      奈良県新公会堂・東大寺総合文化センター、奈良(発表確定)
    • Invited
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Presentation] 神経変性疾患の謎を解く―タンパク分解系からのアプローチ2014
    • Author(s)
      田中啓二
    • Organizer
      第37回日本神経科学会Neuroscience2014, 教育講演
    • Place of Presentation
      パシフィコ横浜、横浜(発表確定)
    • Invited
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Presentation] 神経変性疾患の謎を解く-タンパク分解系からのアフローチー-2014
    • Author(s)
      田中啓二
    • Organizer
      第37回日本神経科学大会(Neuroscience 2014)「神経科学が世界を変える」教育講演
    • Place of Presentation
      パシフィコ横浜, 神奈川県横浜市
    • Year and Date
      2014-09-13
    • Invited
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] タンパク質の新陳代謝～健康と病気のみなもと～2014
    • Author(s)
      田中啓二
    • Organizer
      サイエンステクノフロンティアフォーラムサイテックサロン
    • Place of Presentation
      駒場ファカルティハウス(東京大学駒場キャンパス内、)東京(発表確定)
    • Year and Date
      2014-06-28
    • Invited
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Presentation] 私のプロテアソーム研究～成功と失敗のエピソード～2014
    • Author(s)
      田中啓二
    • Organizer
      新学術領域「ユビキチンネオバイオロジー」領域班会議 -文化功労者 -顕彰記念講演
    • Place of Presentation
      ホテルたつき、愛知県蒲郡市
    • Year and Date
      2014-12-04
    • Invited
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] 私のプロテアソーム研究～偶然が必然を誘う幸運～2014
    • Author(s)
      田中啓二
    • Organizer
      免疫サマースクール
    • Place of Presentation
      オリビアン小豆島、香川県小豆島
    • Year and Date
      2014-07-29
    • Invited
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] Basic mechanisms and physiopathological roles of eukaryotic proteasomes2014
    • Author(s)
      Keiji Tanaka
    • Organizer
      A lecture in "Karolinska Research Lectures" series at Nobel Forum
    • Place of Presentation
      Stockholm, Sweden(発表確定)
    • Year and Date
      2014-09-18
    • Invited
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Presentation] Basic mechanisms and physiopathological roles of eukaryotic proteasomes.2014
    • Author(s)
      K. Tanaka
    • Organizer
      A lecture in "Karolinska Research Lectures" series at Nobel Forum
    • Place of Presentation
      Stockholm, (Sweden)
    • Year and Date
      2014-09-18
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Presentation] Oxidative Stress, Mitophagy, and the PINK1-Parkin System2014
    • Author(s)
      Keiji Tanaka
    • Organizer
      Symposium 17 on Oxidative Stress and Autophagy. 17th Biennial Meeting of Society for Free Radical Research International (SFRRI 2014)
    • Place of Presentation
      Kyoto International Conference Center, Kyoto, Japan
    • Year and Date
      2014-03-26
    • Invited
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Presentation] タンパク質の新陳代謝～健康と病気のみなもと～2014
    • Author(s)
      田中啓二
    • Organizer
      「サイエンステクノフロンティアフォーラム」サイテックサロン
    • Place of Presentation
      駒場ファカルティハウス(東京大学駒場キャンパス内)、東京都目黒区
    • Year and Date
      2014-06-28
    • Invited
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] The vertebrate-specific thymoproteasome governs positive selection in the development of CD8 T lymphocytes2014
    • Author(s)
      Keiji Tanaka
    • Organizer
      The Zomes VIII Conference, Biology of the Zomes-Proteasome, COP9 Signalosome and associated processes.
    • Place of Presentation
      Xiamen, China(発表確定)
    • Invited
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Presentation] 私のフロテアソーム研究～成功と失敗のエピソード～2014
    • Author(s)
      田中啓二
    • Organizer
      国立国際医療研究センター研究所セミナー
    • Place of Presentation
      国立国際医療研究センター、東京都新宿区
    • Year and Date
      2014-12-08
    • Invited
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] The PINK1-Parkin system controls mitochondrial homeostasis to suppress the cause of 'Parkinson's disease.2014
    • Author(s)
      Keiji Tanaka
    • Organizer
      "KSU International Symposium : Cutting-edge of Life Sciences".
    • Place of Presentation
      Kyoto, Japan(発表確定)
    • Invited
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Presentation] Thymoproteasomes play an essential role for the formation of immunocompetent repertoire of CD8 T cells2014
    • Author(s)
      Keiji Tanaka
    • Organizer
      EMBO Conference on Ubiquitin & ubiquitin-like proteins : At the crossroads from chromatin to protein.
    • Place of Presentation
      Buenos Aires, Argentina(発表確定)
    • Invited
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Presentation] 生化学の立場から2014
    • Author(s)
      田中啓二
    • Organizer
      第61回日本栄養改善学会学術集会8/21メインシンポジウムI「栄養学―新たな挑戦 日本栄養改善学会60周年シンポジウム」
    • Place of Presentation
      パシフィコ横浜、横浜(発表確定)
    • Invited
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Presentation] Basic Mechanisms and Physiopathological Roles of Eukaryotic Proteasomes2014
    • Author(s)
      Keiji Tanaka
    • Organizer
      Nobel Forum Lecture
    • Place of Presentation
      Karolinska Institute, Stockholm, SWEDEN
    • Year and Date
      2014-09-18
    • Invited
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] Surveillance of Mitochondrial Homeostasis by the PINK1-Parkin System2014
    • Author(s)
      Keiji Tanaka
    • Organizer
      The 87th Annual Meeting of the Japanese Biochemical Society New Phase in Organelle Biology : Cellular Organellostasis with Mitochondria as a Hub
    • Place of Presentation
      Kyoto International Conference Center, Kyoto
    • Year and Date
      2014-10-15
    • Invited
    • Data Source
      KAKENHI-PROJECT-26000014

  • [Presentation] Physiopathological Roles of the Immune-dedicated Proteasomes in Vertebrate.2013
    • Author(s)
      Keiji Tanaka
    • Organizer
      The Second Immunology Symposium of The University of Tokushima“Immune Development, Deviation, and Regulation”
    • Place of Presentation
      Nichia Medical Hall, Tokushima University Hospital, Tokushima
    • Invited
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Presentation] Pathophysiological Roles of the Proteasome in Vertebrate.2013
    • Author(s)
      Keiji Tanaka
    • Organizer
      The EUROMEDLAB Milano 2013 Congress. [OPENING LECTURE]
    • Place of Presentation
      Milano Convention Center, Milano, Italy.
    • Year and Date
      2013-05-19
    • Invited
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Presentation] オートファジーKOマウスとその応用2013
    • Author(s)
      田中啓二, 小松雅明
    • Organizer
      BioJapan 2013 World Business Forum
    • Place of Presentation
      パシフィコ横浜、横浜
    • Year and Date
      2013-10-11
    • Invited
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Presentation] プロテアソーム―発見から四半世紀の軌跡―2013
    • Author(s)
      Keiji Tanaka
    • Organizer
      大阪大学生命機能研究科研究交流会Frontier Bioscience Colloquium特別講演
    • Place of Presentation
      大阪
    • Year and Date
      2013-05-29
    • Invited
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Presentation] 二つの免疫型プロテアソームの発見-偶然から免疫学の檜舞台へ-2013
    • Author(s)
      田中啓二
    • Organizer
      15th免疫サマースクール2013 in Hakata
    • Place of Presentation
      福岡
    • Year and Date
      2013-07-31
    • Invited
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Presentation] The Ubiquitin-Proteasome System.2013
    • Author(s)
      Keiji Tanaka
    • Organizer
      HUPO 2013 Congress in Yokohama Proteomics of Protein Degradation : Session 11. Keynote Lecture
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2013-09-16
    • Invited
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Presentation] プロテアソームの発見から現在に至る研究の軌跡.2013
    • Author(s)
      田中啓二
    • Organizer
      第29回 前立腺シンポジウム : 教育セミナー1
    • Place of Presentation
      東京コンファレンスセンター・品川、東京
    • Year and Date
      2013-12-14
    • Invited
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Presentation] ミトコンドリアストレスとユビキチン・プロテアソームシステム2013
    • Author(s)
      田中啓二
    • Organizer
      第8回臨床ストレス応答学会
    • Place of Presentation
      信州大学医学部、松本
    • Year and Date
      2013-11-16
    • Invited
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Presentation] Proteasome-over a quarter of a century from its discoveryプロテアソーム-その発見から四半世紀の軌跡2013
    • Author(s)
      田中啓二
    • Organizer
      The 86th Annual Meeting of the Japanese Biochemical Society Globalizing Biochemistry's Future. Plenary Lecture
    • Place of Presentation
      Yokohama (Japan)
    • Year and Date
      2013-09-13
    • Invited
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Presentation] In vivo interplay between the proteasome and autophagy in the mouse liver.2013
    • Author(s)
      Keiji Tanaka
    • Organizer
      The 35th Naito Conference entitled The Ubiquitin-Proteasome. System : From Basic Mechanisms to Pathophysiological Roles.
    • Place of Presentation
      Chateraise Gateaux Kingdom, Sapporo, Japan.
    • Invited
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Presentation] The Keap1-Nrf2 activation during selective autophagy : its implication in tumor development.2013
    • Author(s)
      Keiji Tanaka and Masaaki Komatsu
    • Organizer
      The 72nd Annual Meeting of Japanese Cancer Association Cancer research providing hope to fight against cancer Pacifico Yokohama Symposium 10 on Autophagy in Cancer.
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2013-10-03
    • Invited
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Presentation] Selective Autophagy, Mitochondria, and Tumor Development2013
    • Author(s)
      Keiji Tanaka
    • Organizer
      The 4th International Symposium on Dynamics of Mitochondria (DynaMito 2013)
    • Place of Presentation
      Okinawa Zanpamisaki Royal Hotel, Okinawa, Japan
    • Invited
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Presentation] 私のプロテアソーム研究～成功と失敗の狭間で…2013
    • Author(s)
      田中啓二
    • Organizer
      新学術研究「修飾シグナル病」第2回 若手ワークショップ 別講演
    • Place of Presentation
      伊香保温泉:雨情の湯 森秋旅館、群馬
    • Year and Date
      2013-10-22
    • Invited
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Presentation] Pathophysiological roles of the proteasome in vertebrate2013
    • Author(s)
      K. Tanaka
    • Organizer
      The EUROMEDLAB Milano 2013 Congress
    • Place of Presentation
      Milano Convention Center, Milano (Italy)
    • Year and Date
      2013-05-19
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Presentation] オートファジーとミトコンドリア・ストレス　～その破綻による重篤疾病の発症機構～2012
    • Author(s)
      田中啓二
    • Organizer
      第65回 日本酸化ストレス学会学術集会
    • Place of Presentation
      あわぎんホール 徳島郷土文化会館 、徳島
    • Invited
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Presentation] Pathophysiological roles of immuno-typed proteasomes in vertebrate2012
    • Author(s)
      K. Tanaka
    • Organizer
      ZOMES VII"Ubiquitin family proteins and their cognate PCI complexes"Munich
    • Place of Presentation
      Germany
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Presentation] Naratriptan ameliorates SBMA pathology by the repression of CGRP1-activated JNK pathway2012
    • Author(s)
      Minamiyama M, Katsuno M, Adachi H, Doi H, Kondo N, Iida M, Ishigaki S, Fujioka Y, Matsumoto S, Miyazaki Y, Tanaka F, Kurihara H, Sobue G
    • Organizer
      Neuroscience 2012
    • Place of Presentation
      New Orleans, USA
    • Data Source
      KAKENHI-PROJECT-21229011

  • [Presentation] 巨大で複雑な超分子複合体の構造生命科学-プロテアソームを例とした動態解明-2012
    • Author(s)
      田中啓二
    • Organizer
      学術会議シンポジウム「先端的異分野融合を核とした構造生命科学の飛躍に向けて」
    • Place of Presentation
      日本学術会議講堂、東京(招待講演)
    • Year and Date
      2012-01-09
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Presentation] Naratriptan ameliorates SBMA pathology by the repression of CGRP1-activated JNK pathway.2012
    • Author(s)
      Minamiyama, M., Katsuno, M., Adachi, H., Doi, H., Kondo, N., Iida, M., Ishigaki, S., Fujioka, Y., Matsumoto, S., Miyazaki, Y., Tanaka, F., Kurihara, H., Sobue, G.
    • Organizer
      Neuroscience 2012.
    • Place of Presentation
      New Orleans, USA
    • Data Source
      KAKENHI-PROJECT-21229011

  • [Presentation] PINK1/Parkinによるミトコンドリアの品質管理機構～パーキンソン病の発症機構に挑む～2012
    • Author(s)
      田中啓二
    • Organizer
      九州大学グローバルCOEプログラム理医連携特別講演会:独創的研究の世界発信を続ける「7人の侍」コラボステーションI
    • Place of Presentation
      九州大学・視聴覚ホール、福岡(招待講演)
    • Year and Date
      2012-02-29
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Presentation] p62/SQSTM1 removes toxic mutant androgen receptor in spinal bulbar muscular atrophy model mouse2012
    • Author(s)
      Adachi H, Doi H, Katsuno M, Matsumoto S, Kondo N, Miyazaki Y, Tohnai G, Iida M, Tanaka F, Sobue G
    • Organizer
      Neuroscience 2012
    • Place of Presentation
      New Orleans, USA
    • Data Source
      KAKENHI-PROJECT-21229011

  • [Presentation] プロテアソーム～構造から見た作動・形成機構～2012
    • Author(s)
      田中啓二
    • Organizer
      平成23年度ターゲットタンパク研究プロジェクト公開シンポジウム「ターゲットタンパク研究から見える未来5」
    • Place of Presentation
      学術会議、東京(招待講演)
    • Year and Date
      2012-03-12
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Presentation] The PINK1/Parkin pathway controls mitochondrial homeostasis whose collapse causes Parkinson's disease Gordon Research Conference (GRC)2012
    • Author(s)
      K.Tanaka
    • Organizer
      Neurobiology of Brain Disorders Stonehill College
    • Place of Presentation
      Easton, MA (USA)
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Presentation] Physiopathological Roles of The Vertebrate- Specific Immuno-type Proteasomes.2012
    • Author(s)
      Keiji Tanaka
    • Organizer
      The Centennial of Hashimoto Disease：Symposium II Autoimmune Diseases - Etiology and Therapeutics
    • Place of Presentation
      Fukuoka, Japan
    • Invited
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Presentation] The PINK1/Parkin pathway controls mitochondrial homeostasis whose collapse causes Parkinson’s disease2012
    • Author(s)
      Keiji Tanaka
    • Organizer
      Gordon Research Conference (GRC) Neurobiology of Brain Disorders
    • Place of Presentation
      Stonehill College, Easton, MA,（August 5-12, 2012）USA
    • Invited
    • Data Source
      KAKENHI-PROJECT-21000012

  • [Presentation] p62/SQSTM1 removes toxic mutant androgen receptor in spinal bulbar muscular atrophy model mouse.2012
    • Author(s)
      Adachi, H., Doi, H., Katsuno, M., Matsumoto, S., Kondo, N., Miyazaki, Y., Tohnai, G., Iida, M., Tanaka, F., Sobue, G.
    • Organizer
      Neuroscience 2012.