tanaka keiji 田中啓二

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TANAKA Keiji 田中啓二

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Researcher Number	10108871
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Affiliation (Current)	2025: 公益財団法人東京都医学総合研究所, 基礎医科学研究分野, 理事長 2025: 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 理事長
Affiliation (based on the past Project Information) *help	2020 – 2024: 公益財団法人東京都医学総合研究所, 基礎医科学研究分野, 理事長 2019: 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 理事長 2017: 東京都医学総合研究所, 理事長 2012 – 2017: 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 所長 2014: 公益財団法人東京都医学総合研究所, 所長 … More 2014: 公益財団法人東京都医学総合研究所, 研究所, 所長 2013: 東京都医学総合研究所, 所長 2011: 財団法人東京都医学総合研究所, 生体分子先端研究分野, 所長 2010: 東京都臨床医学総合研究所, 所長代行 2009 – 2010: (財)東京都医学総合研究所, 東京都臨床医学総合研究所, 理事 2009: 東京都医学研究機構, 研究員 2009: Tokyo Metropolitan Organization for Medical Research, 東京都臨床医学総合研究所, 参事研究員 2008: Tokyo Metropolitan Organization for Medical Research, 東京都臨床医学総合研究所, 参事研究員 2007: Tokyo Metropolitan Organization for Medical Research, 東京都臨床医学総合研究所, 参事研究員 2005 – 2006: (財)東京都医学研究機構, 東京都臨床医学総合研究所, 参事研究員 2005: 東京都医学研究機構, 研究員 2004: the tokyo metropolitan institute of medical science, the tokyo metropolitan institute of medical science, Acting Director, 東京都臨床医学綜合研究所, 参事研究員 2001 – 2004: 財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 参事研究員 2000 – 2004: 東京都臨床医学総合研究所, 部長 2000: Tokyo Metropolitan Institute of Medical Science, Laboratory Chief, 部長(研究職) 2000: 東京都臨床医学総合研究所, 分子腫瘍学研究部門, 部長(研究職) 1999: 東京都・臨床医学総合研究所, 部長(研究職) 1996 – 1998: 東京都臨床医学総合研究所, 部長 1997: (財)東京都臨床医学総合研究所, 化学療法研究部門, 研究員 1997: The Tokyo Metropolitan Institute of Medical Science, Researcher, 化学療法研究部門, 研究員 1997: Researcher, 化学療法・研究部門, 研究員 1996: 財団法人東京都臨床医学総合研究所, 化学療法研究部門, 研究員 1996: 財団法人東京都臨床医学総合研究所, 科学療法研究部門, 研究員 1994 – 1996: 徳島大学, 酵素科学研究センター, 教授 1995: Tokushima Univ., 酵素科学研究センター, 助教授 1987 – 1994: 徳島大学, 酵素科学研究センター, 助手 1990: 徳島大, 酵素センター, 助手 1989 – 1990: 徳島大学, 酵素センター, 助手 1989: Institute for Enzyme Research, University of Tokushima, Research Assistant, 助手 1986: 徳島大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Biological Sciences / Medium-sized Section 44:Biology at cellular to organismal levels, and related fields / Pathological medical chemistry / Cell biology / General medical chemistry / Structural biochemistry / Functional biochemistry / 物質生物化学 Except Principal Investigator Biological Sciences / Pathological medical chemistry … More / Neurology / Urology / General medical chemistry / Biophysics / Human pathology / Biological Sciences / Structural biochemistry Less
Keywords	Principal Investigator プロテアソーム / ユビキチン / タンパク質分解 / ubiquitin / proteasome / ATP依存性プロテアーゼ / 蛋白質分解 / 抗原プロセシング / PA28 / 脳神経疾患 … More / 蛋白質 / ATP / 神経変性疾患 / オートファジー / 蛋白分解 / 細胞周期 / 多成分複合体 / Ubiquitin / 品質管理 / TAP / MHC / 液-液相分離 / メンブレンレスオルガネラ / 液滴 / RAD23B / プロテアソーム顆粒 / プロテオーム / 免疫学 / 酵素 / バイオテクノロジー / ユビキチンリガーゼ / 免疫識別 / 抗原提示 / ストレス応答 / 遺伝子破壊 / 一次構造 / プロテアソ-ム / TAT / Parkinson / Mitochondria / Parkinson's disease / DJ-1 / mitochondria / 相分離 / Proteolysis / Proteasome / 液ー液相分離 / 液一液相分離 / PROTACs / 遺伝学的解析 / 液―液相分離 / 細胞内タンパク質分解 / Molecular Structure / Multisubunit Complex / Multifunctional Enzyme / Intracellular Protease / 多機能酵素複合体 / 20S粒子 / プロテアーゼ複合体 / 高分子量プロテアーゼ / 造腫瘍性変動 / 遺伝子構造 / 細胞内分布 / 活性調節 / 分子構造 / 巨大分子 / 多機能酵素 / 細胞内プロテアーゼ / neurodegenerative diseases / protein / stress / signal transduction / enzyme / ユビキチン様蛋白質 / NEDD8 / SCF / ストレス / シグナル伝達 / ATP-dependent protease / primary structure / cDNA cloning / proteolysis / structure-function relationship / gene disruption / ATPase / 構造-機能相関 / cDNAクローニング / CDNAクローニング / 構造機能相関 / antigenic peptide / endogenous antigen / antigen presentation / antigen processing / キラーT細胞 / 免疫制御 / 抗原プロセッシング / 抗原エピトープ / 免疫プロテアソーム / インターフェロン-γ / 抗原ペプチド / TAp / 内在性抗原 / バノオテクノロジー / マイトファジー / autophagy / 胸腺特異的プロテアソーム / ガン / 分子多様性 / 分子集合 / CDKキナーゼ / サイクリン / 免疫始動制御 / 細胞周期制御 / 熱ショック蛋白HSP70 / 分子シャペロン / 酵母 / 分子遺伝学 / 細胞増殖 / 多機能プロテア-ゼ / 高分子量プロテア-ゼ / cDNAクロ-ニング / 多機能プロテア-ゼ複合体 … More Except Principal Investigator プロテアソーム / 蛋白分解 / ユビキチン / 増殖因子 / オートファジー / プロテアーゼ / 細胞周期 / プロテアソ-ム / 肝細胞 / Proteasome / 増殖抑制因子 / NMR / 初代培養 / Nda1 / MCM / 26S proteasone / Mos / Tom1 / K-252a / RCC1 / エネルギー依存性蛋白分解 / 抗原プロセシング / エネルギー依存性蛋白質分解 / 多機能プロテア-ゼ複合体 / インターロイキン / 分化 / 細胞膜調節因子 / 初代培養肝細胞 / TGF-β / リソソーム / X線構造解析 / バイオモジュレーター / カルパイン / プロテオリシス / 肝再生 / 細胞接触 / 蛋白分解酵素 / 細胞増殖因子 / 神経変性疾患 / 脳神経疾患 / 遺伝子 / 生理学 / 細胞・組織 / 蛋白質 / 細胞内分解 / Phorbol ester(TPA) / cAMP / Interleukin-1beta / Transforming growth factor(TGF)-beta / Cell contact / Primary culture / Growth factors / Hepatocytes / 組織構築 / 細胞分化 / 増殖と機能 / 肝細胞培養 / 肝組織 / 混合培養 / 細胞膜 / DNA合成 / 細胞間相互作用 / 増殖 / ホルボ-ルエステル / cyclic AMP / Interleukin(IL-1) / Transfoming Growth Factor(TGF-beta) / ホルボル・エステル(TPA) / CAMP / Interleukin-1β / Transforming growth factor(TGF)-β / Ornithine Decarboxylase / Calpain / Proteases / Protein Degradation / Proteolysis / トリプターゼ / X線解析 / オルニチン脱炭酸酵素 / Immuno-response / Crystal Structure / 細胞内蛋白分解 / X線結晶解析 / 免疫応答 / X線結晶構造解析 / ACTIVATING FACTOR / INTERFERON-gamma / ANTIGEN PRESENTATION / ANTIGEN PROSECCING / PROTEASOME / MHCクラスI / プロテアソーム活性化因子 / γ型インターフェロン / 活性化因子 / インターフェロンγ / 抗原提示 / immunohistochemistry / cell degeneation / ubiquitin / inhibitor / protease / aging / Alzheimer's disease / 免疫組織化学 / 細胞変性 / インヒビター / 老化 / アルツハイマー病 / yeast mutant pre1-1 / reticulocyte lysate / 26S proteasomes / energy-dependent proteolysis / mutant protein / primary hyperoxaluria type 1 / alanine : glyoxylate aminotransferase / serine : pyruvate aminotransferase / ユビキチン系 / 蓚酸 / 酵母変異株prel-1 / エネルギー症候性蛋白質分解 / 酵母変異株pre1-1 / 網状赤血球溶血液 / 26Sプロテアソーム / 変異蛋白質 / 原発性高蓚酸尿症1型 / アラニン:グリオキシル酸トランスアミナーゼ / セリン:ピルビン酸トランスアミナーゼ / Cyclin A / G2ブロック / MPF / PCC / セントロメア / サイクリン / G2 / CDC2 / 染色体 / cdc28 / TOMI / MOS / ライセンス因子 / CyclinA / Biosensor / Protein interaction / Gene targeting / Higher plants / Morphogenesis / Cre-loxP / Fission yeast / 植物 / 胚形成 / 蛋白高次機能構造 / 遺伝子ターゲティング / RNAプロセシング / バイオモニタリング / DNA再複製 / 温度感受性突然変異体 / ATPase / 免疫病 / 免疫系 / バイオセンサー / 分子相互作用 / 遺伝子標的 / 高等植物 / 形態形成 / Cre-IoxP / 分裂酵母 / MHC classI-restricted antigen presentation / Gamma-interferon / Supramolecular complex / Antigen Processing / Cell cycle / Energy-dependent proteolysis / Ubiquitin / 細胞増殖・分化 / エネルギ-依存性分子識別 / 蛋白質超分子複合体 / エネルギー依存性分子識別 / 分子適合 / 抗原プロセシング・提示 / 細胞内蛋白質分解機構 / 遺伝子転写制御機構 / 多機能プロテアーゼ複合体 / MHCクラスI拘束性抗原提示 / MHCクラスエ拘束性抗原提示 / ガンマ型インターフェロン / 超分子複合体 / High molecular weight protease / Multisubunit complex / Structural analysis / Multicatalytic protease / Proteasomes / 発生と分化 / cDNAクロ-ニング / 20S環状粒子 / 細胞内プロテア-ゼ / 分子遺伝学 / 高分子量プロテア-ゼ / 構造解析 / 多成分複合体 / 多機能プロテア-ゼ / 肝癌細胞 / 血小板 / 細胞増殖調節 / 前癌状態 / 過形成腫粒 / 肝細胞の増殖と分化 / 自己免疫病 / HLA立体構造 / ゲノム / 疾病 / HLA / データベース / 疾病感受性 / 進化 / 自己免疫疾患 / 移植 / 疾患抵抗性 / 疾患感受性 / 立体構造 / ゲノム多様性 / ＨＬＡ / シグナル伝達 / 複合体 / 電子顕微鏡 / X線結晶学 / 相互作用 / タンパク質 / 生物物理学 / 分子生物学 / 細胞生物学 / 生化学 / 構造生物学 / ミトファジー / パーキンソン病 / calcitonin-related polypeptide(CGRP1) / calcitonin / calcitonin/calcitonin-related polypeptide(CGRP1) / セロトニン受容体アゴニスト / 転写障害 / ユビチキン / ポリグルタミン / )球脊髄性筋萎縮症 / 分子シャペロン / ユビキチン-プロテアゾーム系 / 運動ニューロン / JNK / 神経変性 / 球脊髄性筋萎縮症 / ポリグルタミン病 / ホームページ / 基質蛋白質の選別 / モディファイアー蛋白質 / モディファイアー蛋白 / 蛋白質分解 / 免疫プロテアソーム / 蛋白質の寿命 / 蛋白質分解酵素 / オルニチン脱炭素酵素 / バイオモジュレータ / 遺伝子発現 / 腎細胞癌 / 肝臓機能 / 遺伝子破壊 / 癌胎児性蛋白 / 生物工学 / 遺伝子操作 / ツメガエル卵の発現系 / 肝細胞の初代培養 / 卵母細胞 / マイクロインジェクション / ヒト単球 / 細胞工学 / 発現ベクタ- / 増殖制御因子 / 蛋白復合体 / 白血病細胞 / 異常発現 / 細胞増殖 / がん細胞 / 多機能プロテアーゼ / Tーキニノーゲン / processing / 発情勃起 / 神経腫瘍 / 経胎盤投与 / エチルニトロソ尿素 / 無アルブミンラット Less

プロテアソーム：相分離とユビキチンが拓く生理病態学Principal Investigator
- Principal Investigator
  
  田中啓二
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 44:Biology at cellular to organismal levels, and related fields
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Cell Biology of ProteasomesPrincipal Investigator
- Principal Investigator
  
  TANAKA Keiji
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 44:Biology at cellular to organismal levels, and related fields
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
リン酸化ユビキチンを手がかりにマイトファジーの全貌にせまるPrincipal Investigator
- Principal Investigator
  
  田中啓二
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Research Field
  
  Cell biology
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
The Proteasome: Mechanistic Actions and In-depth Physiopathological AnalysesPrincipal Investigator
- Principal Investigator
  
  TANAKA Keiji
- Project Period (FY)
  2014 – 2019
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Multidisciplinary research on autophagy: from molecular mechanisms to disease states
- Principal Investigator
  
  Mizushima Noboru
- Project Period (FY)
  2013 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Structural basis of cell-signaling complexes mediating signal perception, transduction and responses.
- Principal Investigator
  
  HAKOSHIMA Toshio
- Project Period (FY)
  2010 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Nara Institute of Science and Technology
Integrated redearch for HLA disease and evolution
- Principal Investigator
  
  SASAZUKI Takehiko
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
In-depth Analysis of Proteasome-Mediated Regulatory ProteolysisPrincipal Investigator
- Principal Investigator
  
  TANAKA Keiji
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Development of Molecular Targeted Disease Modifying Therapy for Polyglutamine Diseases
- Principal Investigator
  
  SOBUE Gen
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Neurology
- Research Institution
  Nagoya University
Effects of mitophagy on cell death in Parkinson's disease model cells
- Principal Investigator
  
  SAIKI Shinji
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Juntendo University
Analyses of Molecular Assembly and Diversity of ProteasomesPrincipal Investigator
- Principal Investigator
  
  TANAKA Keiji
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
Studies on proteolysis mediated by the proteasomes and ubiquitinPrincipal Investigator
- Principal Investigator
  
  TANAKA Keiji
- Project Period (FY)
  2001 – 2005
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
蛋白質分解-新しいモディフアイアー蛋白質による制御
- Principal Investigator
  
  木南英紀
- Project Period (FY)
  2000 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Juntendo University
プロテアソームによる細胞周期と免疫始動制御Principal Investigator
- Principal Investigator
  
  田中啓二
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
蛋白分解のニューバイオロジー
- Principal Investigator
  
  鈴木紘一
- Project Period (FY)
  1996 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tokyo Metropolitan Institute of Gerontology
  The University of Tokyo
プロテアソームの分子様態・結晶構造と機能解析に関する研究
- Principal Investigator
  
  MORIMOTO Yukio
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Himeji Institute of Technology
Mechanism of Selective Degradation of Proteins
- Principal Investigator
  
  SUZUKI Koichi
- Project Period (FY)
  1996 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Metropolitan Institute of Gerontology
  The University of Tokyo
プロテアソームによる細胞周期の制御Principal Investigator
- Principal Investigator
  
  田中啓二
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokushima
バイオモジュレーターとしてのプロテアーゼ
- Principal Investigator
  
  SUZUKI Koichi
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  The University of Tokyo
プロテアソームの分子構造と細胞生物学的機能解析Principal Investigator
- Principal Investigator
  
  田中啓二
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  The University of Tokushima
Development of the reconstituted antigen presenting system and its medical applicationPrincipal Investigator
- Principal Investigator
  
  TANAKA Keiji
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The Tokyo Metropolitan Institute of Medical Science
  The University of Tokushima
Crystal Structure Analysis of Bovine 20S Proteasome at High Resolution.
- Principal Investigator
  
  MORIMOTO Yukio
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  Himeji Institute of Technology
  The University of Tokushima
Structural and genetic analysis of proteasomesPrincipal Investigator
- Principal Investigator
  
  TANAKA Keiji
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  The Tokyo Metropolitan Institute of Medical Science
蛋白質分解システムとストレス応答Principal Investigator
- Principal Investigator
  
  田中啓二
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokushima
Intracellular Degradation of a Mutant Serine : Pyruvate/Alanine : Glyoxylate Aminotransferase
- Principal Investigator
  
  ICHIYAMA Arata
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Hamamatsu University School of Medicine
Abnormal Expressions of Proteases and Inhibitors in the brains of Alzheimer's disease and aging.
- Principal Investigator
  
  II Kunio
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  The University of Tokushima
RESEARCH FOR THE MHC CLASS I RESTRICTED ANTIGEN PROCESSING AND PRESENTATION
- Principal Investigator
  
  AKIYAMA Kinya, 安芸雅史
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  THE UNIVERSITY OF TOKUSHIMA
Regulation of Gene Expression
- Principal Investigator
  
  TANIGUCHI Masaru
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Chiba University
Regulation of MPF activation and Institute of Mitosis
- Principal Investigator
  
  NISHIMOTO Takeharu
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
Studies on structure and the biological functions of a large multi-molecular complex "the proteasome"
- Principal Investigator
  
  ICHIHARA Akira
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Research Institution
  Institute for Enzyme Research, The University of Tokushima
プロテアソ-ム(巨大蛋白分解酵素復合体)の構造解析と癌化における発現異常の解明
- Principal Investigator
  
  市原明
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokushima
培養肝細胞を用いた機能と増殖を調節する肝組織構築の生化学的研究
- Principal Investigator
  
  市原明
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokushima
尿路性器癌におけるプロテアソ-ムの異常発現機構に関する研究
- Principal Investigator
  
  香川征
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  The University of Tokushima
遺伝子破壊法による酵母プロテアソ-ム(巨大蛋白分解酵素複合体)の機能解析Principal Investigator
- Principal Investigator
  
  田中啓二
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  物質生物化学
- Research Institution
  The University of Tokushima
無アルブミンラットによる癌研究
- Principal Investigator
  
  長瀬すみ
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Sasaki Institute
多機能プロテアーゼ復合体(プロテアソーム)の機能と癌化における異常発現機構の解析
- Principal Investigator
  
  ICHIHARA Akira
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokushima
真核生物に遍在するプロテアソ-ム(多成分プロテア-ゼ復合体)の遺伝子構造解析Principal Investigator
- Principal Investigator
  
  田中啓二
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokushima
肝細胞増殖制御因子の生物工学的技法による同定,遺伝子構造解析と大量生産のシステム化
- Principal Investigator
  
  市原明
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  The University of Tokushima
Structure and Cell Biology of a Novel Multicatalytic Proteinase Complex
- Principal Investigator
  
  ICHIHARA Akira
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  General medical chemistry
- Research Institution
  The University of Tokushima
培養肝細胞を用いた増殖と分化の制御機構の研究
- Principal Investigator
  
  市原明
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokushima
培養肝細胞を用いた増殖と分化の制御機構の研究
- Principal Investigator
  
  市原明
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokushima
Molecular Structure and Functional Propeerties of a High Molecular Weight-Multiprotease ComplexPrincipal Investigator
- Principal Investigator
  
  TANAKA Keiji
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  The University of Tokushima
培養肝細胞を用いた増殖と分化の制御機構の研究
- Principal Investigator
  
  市原明
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokushima
Biochemical studies on tissue architecture of liver, which controls functions and growth, using primary cultured hepatocytes
- Principal Investigator
  
  ICHIHARA Akira
- Project Period (FY)
  1986 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  University of Tokushima

[Book] 実験医学2020
- Author(s)
  田中啓二、若槻壮市
- Total Pages
  240
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-19H00997
[Book] 「構造生命科学からトランススケール・イメージングによる細胞動態学へ」実験医学増刊号2020
- Author(s)
  田中啓二、若槻壮市(編集)
- Total Pages
  240
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-26000014
[Book] Medical Science Digest2019
- Author(s)
  田中啓二
- Total Pages
  35
- Publisher
  ニューサイエンス社
- Data Source
  KAKENHI-PROJECT-19H00997
[Book] Ubiquitin chain elongation : An intriguing strategy. Mol Cell (preview)2014
- Author(s)
  Iwai, K. and Tanaka, K.
- Total Pages
  3
- Publisher
  Cell Press
- Data Source
  KAKENHI-PROJECT-26000014
[Book] プログレッシブ生命科学　（第一版）2014
- Author(s)
  吉森保、岡正啓、米田悦啓、田中亀代次、西條將文、岩井一宏、菊池章、松本真司、岡村康司、山本浩靖、木原進士、松岡達、高木都、犬束歩、山中章弘、金井好克、磯谷綾子、伊川正人古川貴久、戸田達史、他
- Total Pages
  312
- Publisher
  南山堂
- Data Source
  KAKENHI-ORGANIZER-25111001
[Book] FROM EAST TO WEST : Pioneers in Parkinson's disease in Japan-A historical overview of major achievement in research2014
- Author(s)
  Tanaka, K.
- Total Pages
  2
- Publisher
  QOL laboratory Corp
- Data Source
  KAKENHI-PROJECT-26000014
[Book] Keio J.Med.2012
- Author(s)
  Tanaka, K.
- Publisher
  慶應義塾大学(in press)
- Data Source
  KAKENHI-PROJECT-21000012
[Book] Brain and Nerve2012
- Author(s)
  松田憲之, 田中啓二, 小松雅明
- Total Pages
  6
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-21000012
[Book] Curr.Opini.Immunol2012
- Author(s)
  Takahama, Y., Takada, K., Murata, S., Tanaka, K.
- Total Pages
  7
- Publisher
  Elsevier Ltd.
- Data Source
  KAKENHI-PROJECT-21000012
[Book] 「アレルギー」(社)日本アレルギー学会編2012
- Author(s)
  田中啓二
- Publisher
  (社)日本アレルギー学会(印刷中)
- Data Source
  KAKENHI-PROJECT-21000012
[Book] Annual Review 2012神経2012
- Author(s)
  田中啓二, 松田憲之, 尾勝圭
- Total Pages
  6
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-21000012
[Book] 化学と生物(日本農芸化学会学会誌)2011
- Author(s)
  松田憲之, 田中啓二
- Total Pages
  7
- Publisher
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-21000012
[Book] 実験医学2011
- Author(s)
  松田憲之, 尾勝圭, 田中啓二
- Total Pages
  7
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-21000012
[Book] Assembly and function of the proteasome. "Ubiquitin Family Modifiers and the Proteasome : Reviews and Protocols"2011
- Author(s)
  Saeki, Y, Tanaka, K.
- Publisher
  Humana Press. SPRINGER SCIENCE+BUSINESS MEDIA, New York, (USA)(In press)
- Data Source
  KAKENHI-PROJECT-21000012
[Book] Surgery Frontier 2011年6月号特集2011
- Author(s)
  田中啓二
- Total Pages
  6
- Publisher
  メジカルビュー社
- Data Source
  KAKENHI-PROJECT-21000012
[Book] 病理と臨床2011
- Author(s)
  田中啓二
- Total Pages
  5
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-21000012
[Book] ライフサイエンス「新着論文レビュー」2011
- Author(s)
  佐伯泰、田中啓二
- Publisher
  大学共同利用機関法人情報・システム研究機構ライフサイエンス統合データベースセンター
- Data Source
  KAKENHI-PROJECT-21000012
[Book] 実験医学2011年7月増刊2011
- Author(s)
  田中啓二
- Total Pages
  8
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-21000012
[Book] 日本栄養・食糧学会誌2011
- Author(s)
  田中啓二
- Total Pages
  8
- Publisher
  公益社団法人日本栄養・食糧学会(総説)
- Data Source
  KAKENHI-PROJECT-21000012
[Book] Methods in Molecular Biology2011
- Author(s)
  Saeki, Y, Tanaka, K.
- Total Pages
  23
- Publisher
  Humana Press. New York (USA)
- Data Source
  KAKENHI-PROJECT-21000012
[Book] Bio Clinica2011
- Author(s)
  松田憲之, 田中啓二
- Total Pages
  5
- Publisher
  北隆館
- Data Source
  KAKENHI-PROJECT-21000012
[Book] 神経内科2011
- Author(s)
  井口正寛, 松田憲之, 田中啓二
- Total Pages
  7
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-21000012
[Book] ユビキチンとプロテアソーム : 炎症・再生医学辞典2009
- Author(s)
  田中啓二
- Publisher
  朝倉書店(印刷中)
- Data Source
  KAKENHI-PROJECT-17002019
[Book] ユビキチン・プロテアソーム・オートファジー : 免疫の事典2009
- Author(s)
  田中啓二
- Publisher
  朝倉書店(印刷中)
- Data Source
  KAKENHI-PROJECT-17002019
[Book] 蛋白質の寿命 : 蛋白質の事典2009
- Author(s)
  田中啓二
- Publisher
  朝倉書店(印刷中)
- Data Source
  KAKENHI-PROJECT-17002019
[Book] 巨大で複雑な蛋白質分解装置の動態と作動機構「構造プロテオミクスの新時代 : 医薬の分子設計と構造生物学の融合」蛋白質核酸酵素増刊号2009
- Author(s)
  水島恒裕・田中啓二
- Publisher
  共立出版(印刷中)
- Data Source
  KAKENHI-PROJECT-17002019
[Book] 「分子細胞生物学辞典」:免疫プロテアソーム・ハイブリッドプロテアソーム2008
- Author(s)
  田中啓二
- Publisher
  東京化学同人
- Data Source
  KAKENHI-PROJECT-17002019
[Book] ユビキチン-プロテアソーム系「細胞の蛋白質品質管理機構と心血管疾患」血管医学2008
- Author(s)
  田中啓二
- Total Pages
  4
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-17002019
[Book] 「分子細胞生物学辞典」 : 免疫プロテアソーム・ハイブリッドプロテアソーム2008
- Author(s)
  田中啓二(分担)
- Total Pages
  2
- Publisher
  東京化学同人
- Data Source
  KAKENHI-PROJECT-17002019
[Book] ユビキチンと神経変性 : 臨床神経科学(Clinical Neuroscience)2008
- Author(s)
  田中啓二
- Total Pages
  2
- Publisher
  中外医薬社
- Data Source
  KAKENHI-PROJECT-17002019
[Book] プロテアソームの新しいユビキチンレセプター. 細胞工学2008
- Author(s)
  佐伯泰、田中啓二
- Publisher
  学研メディカル秀潤社
- Data Source
  KAKENHI-PROJECT-17002019
[Book] プロテアソームの新しいユビキチンレセプター.細胞工学2008
- Author(s)
  佐伯泰、田中啓二
- Total Pages
  2
- Publisher
  秀潤社
- Data Source
  KAKENHI-PROJECT-17002019
[Book] プロテアソーム:キーワード:蛋白質の一生「蛋白質核酸酵素」増刊号2008
- Author(s)
  田中啓二
- Publisher
  共立出版
- Data Source
  KAKENHI-PROJECT-17002019
[Book] ユビキチンと神経変性:臨床神経科学(Clinical Neuroscience)2008
- Author(s)
  田中啓二
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-17002019
[Book] プロテアソーム : キーワード : 蛋白質の一生.蛋白質核酸酵素」増刊号2008
- Author(s)
  田中啓二
- Total Pages
  7
- Publisher
  共立出版
- Data Source
  KAKENHI-PROJECT-17002019
[Book] 蛋白質の寿命:蛋白質の事典2008
- Author(s)
  田中啓二
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-17002019
[Book] Ubiquity and diversity of the proteasome system. In " Protein Degradation"(Eds. By Mayer, R. J., Ciechanover, A., and Rechsteiner, M.)2006
- Author(s)
  Tanaka, K., Yashiroda, H., Murata, S.
- Publisher
  Wiley-VCH Verlag GmbH, Weinheim, Germany
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13002008
[Book] Ubiquity and diversity of the proteasome system. In " Protein Degradation" (Eds. By Mayer, R. J., Ciechanover, A., and Rechsteiner, M.)2006
- Author(s)
  Tanaka, K., Yashiroda, H., Murata, S.
- Publisher
  Wiley-VCH Verlag GmbH, Weinheim, Germany
- Data Source
  KAKENHI-PROJECT-17002019
[Book] Ubiquity and diversity of the proteasome system. In "Protein Degradation"(Eds. By Mayer, R.J., Ciechanover, A., and Rechsteiner, M.)2006
- Author(s)
  Tanaka, K.
- Publisher
  Wiley-VCH Verlag GmbH, Weinheim, Germany in press
- Data Source
  KAKENHI-PROJECT-17002019
[Book] Methods in Enzymology : Large- and small-scale purification of mammalian 26S proteasomes.2005
- Author(s)
  Hirano, Y., Murata, S., Tanaka, K.
- Publisher
  Academic Press, New York(in press)
- Data Source
  KAKENHI-PROJECT-13002008
[Book] Preparation of proteasomes. in "Cell Biology : A Laboratory Handbook" (Ed. by J.E.Celis) 3rd edition.2005
- Author(s)
  Tanaka, K.
- Publisher
  Academic Press, New York
- Data Source
  KAKENHI-PROJECT-17002019
[Book] 巨大で複雑な蛋白質分解装置の動態と作動機構「構造プロテオミクスの新時代:医薬の分子設計と構造生物学の融合」蛋白質核酸酵素増刊号
- Author(s)
  水島恒裕・田中啓二
- Publisher
  共立出版
- Data Source
  KAKENHI-PROJECT-17002019
[Book] ユビキチン・プロテアソーム・オートファジー:免疫の事典
- Author(s)
  田中啓二
- Publisher
  朝倉書店(印刷中)
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] Changes in brain proteasome dynamics associated with aging2024
- Author(s)
  Nago Nodoka、Murata Shigeo、Tanaka Keiji、Tanahashi Nobuyuki
- Journal Title
  
  Genes to Cells
  
  Volume: - Issue: 5 Pages: 1-8
- DOI
  10.1111/gtc.13113
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K17650, KAKENHI-PLANNED-23H04918, KAKENHI-PROJECT-22H00419
[Journal Article] Optineurin provides a mitophagy contact site for TBK1 activation2024
- Author(s)
  Yamano Koji、Sawada Momoha、Kikuchi Reika、Nagataki Kafu、Kojima Waka、Endo Ryu、Kinefuchi Hiroki、Sugihara Atsushi、Fujino Tomoshige、Watanabe Aiko、Tanaka Keiji、Hayashi Gosuke、Murakami Hiroshi、Matsuda Noriyuki
- Journal Title
  
  The EMBO Journal
  
  Volume: 43 Issue: 5 Pages: 754-779
- DOI
  10.1038/s44318-024-00036-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-19H05712, KAKENHI-WRAPUP-23H05424, KAKENHI-ORGANIZER-23H04917, KAKENHI-PLANNED-23H04923, KAKENHI-PROJECT-22H00419, KAKENHI-PROJECT-23K23841
[Journal Article] USP8 prevents aberrant NF-kappaB and Nrf2 activation by counteracting ubiquitin signals from endosomes.2024
- Author(s)
  Endo A, Fukushima T, Takahashi C, Tsuchiya H, Ohtake F, Ono S, Ly T, Yoshida Y, Tanaka K, Saeki Y, Komada M.
- Journal Title
  
  Journal of Cell Biology
  
  Volume: 223(3) Issue: 3 Pages: 1-1
- DOI
  10.1083/jcb.202306013
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06039, KAKENHI-ORGANIZER-23H04917, KAKENHI-PLANNED-23H04921, KAKENHI-PROJECT-23H05479, KAKENHI-PROJECT-22H00419, KAKENHI-PROJECT-23K23571
[Journal Article] Elucidation of ubiquitin-conjugating enzymes that interact with RBR-type ubiquitin ligases using a liquid-liquid phase separation-based method2023
- Author(s)
  Hayashida Ryota、Kikuchi Reika、Imai Kenichiro、Kojima Waka、Yamada Tatsuya、Iijima Miho、Sesaki Hiromi、Tanaka Keiji、Matsuda Noriyuki、Yamano Koji
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 299 Issue: 2 Pages: 102822-102822
- DOI
  10.1016/j.jbc.2022.102822
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H00419, KAKENHI-PLANNED-19H05712, KAKENHI-PROJECT-23K23841
[Journal Article] The effect of nutrient deprivation on proteasome activity in 4-week-old mice and 24-week-old mice2022
- Author(s)
  Nobuyuki Tanahashi, Moeko Komiyama, Mina Tanaka, Yuta Yokobori Shigeo Murata, and Keiji Tanaka
- Journal Title
  
  Journal of Nutritional Biochemistry
  
  Volume: 0 Pages: 0-0
- DOI
  10.1016/j.jnutbio.2022.108993
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K11658, KAKENHI-PROJECT-18H04022, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-22H00402, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05500
[Journal Article] cIAP1-based degraders induce degradation via branched ubiquitin architectures2022
- Author(s)
  Akizuki Yoshino、Morita Mai、Mori Yuki、Kaiho-Soma Ai、Dixit Shivani、Endo Akinori、Shimogawa Marie、Hayashi Gosuke、Naito Mikihiko、Okamoto Akimitsu、Tanaka Keiji、Saeki Yasushi、Ohtake Fumiaki
- Journal Title
  
  Nature Chemical Biology
  
  Volume: 19 Issue: 3 Pages: 311-322
- DOI
  10.1038/s41589-022-01178-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22H00419, KAKENHI-PROJECT-20K06568, KAKENHI-PROJECT-21K19040, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05498, KAKENHI-PLANNED-18H05502, KAKENHI-PLANNED-18H05504, KAKENHI-PROJECT-21H02777
[Journal Article] Unfolding is the driving force for mitochondrial import and degradation of the Parkinson's disease-related protein DJ-12021
- Author(s)
  Queliconi BB, Kojima W, Kimura M, Imai K, Udagawa C, Motono C, Hirokawa T, Tashiro S, Caaveiro JMM, Tsumoto K, Yamano K, Tanaka K, Matsuda N
- Journal Title
  
  J Cell Sci
  
  Volume: 134 Issue: 22 Pages: 1-1
- DOI
  10.1242/jcs.258653
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11543, KAKENHI-PROJECT-18H02443, KAKENHI-PLANNED-18H05500, KAKENHI-PLANNED-19H05712, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-20H02531
[Journal Article] Loss of peptide: N -glycanase causes proteasome dysfunction mediated by a sugar-recognizing ubiquitin ligase2021
- Author(s)
  Yoshida Yukiko、Asahina Makoto、Murakami Arisa、Kawawaki Junko、Yoshida Meari、Fujinawa Reiko、Iwai Kazuhiro、Tozawa Ryuichi、Matsuda Noriyuki、Tanaka Keiji、Suzuki Tadashi
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 118 Issue: 27
- DOI
  10.1073/pnas.2102902118
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02443, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05499, KAKENHI-PLANNED-19H05712, KAKENHI-PROJECT-17H06174, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-19H02926
[Journal Article] TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains2021
- Author(s)
  Kaiho-Soma Ai、Akizuki Yoshino、Igarashi Katsuhide、Endo Akinori、Shoda Takuji、Kawase Yasuko、Demizu Yosuke、Naito Mikihiko、Saeki Yasushi、Tanaka Keiji、Ohtake Fumiaki
- Journal Title
  
  Molecular Cell
  
  Volume: 81 Issue: 7 Pages: 1411-1424.e7
- DOI
  10.1016/j.molcel.2021.01.023
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07009, KAKENHI-PROJECT-17H01882, KAKENHI-PLANNED-18H05498, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-20K22726, KAKENHI-PROJECT-17H03986, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-21H03604, KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-20K21408
[Journal Article] Mammalian BCAS3 and C16orf70 associate with the autophagosome formation site in response to selective and non-selective autophagy2021
- Author(s)
  Kojima, K., Yamano, K., Kosako, H., Imai, K., Kikuchi, R., Tanaka, K., and Matsuda, M.
- Journal Title
  
  Autophagy
  
  Volume: 17 Pages: 2011-2036
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H00997
[Journal Article] Critical role of mitochondrial ubiquitination and the OPTN?ATG9A axis in mitophagy2020
- Author(s)
  Yamano Koji、Kikuchi Reika、Kojima Waka、Hayashida Ryota、Koyano Fumika、Kawawaki Junko、Shoda Takuji、Demizu Yosuke、Naito Mikihiko、Tanaka Keiji、Matsuda Noriyuki
- Journal Title
  
  Journal of Cell Biology
  
  Volume: 219 Issue: 9 Pages: 1-23
- DOI
  10.1083/jcb.201912144
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-19K07009, KAKENHI-PLANNED-18H05500, KAKENHI-PLANNED-18H05502, KAKENHI-PLANNED-19H05712, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-18K06237, KAKENHI-ORGANIZER-18H05497
[Journal Article] Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses.2020
- Author(s)
  Oikawa D, Sato Y, Ohtake F, Komakura K, Hanada K, Sugawara K, Terawaki S, Mizukami Y, Phuong HT, Iio K, Obika S, Fukushi M, Irie T, Tsuruta D, Sakamoto S, Tanaka K, Saeki Y, Fukai S, Tokunaga F.
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  Commun. Biol.
  
  Volume: 3 Issue: 1 Pages: 163-163
- DOI
  10.1038/s42003-020-0882-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22541, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-ORGANIZER-16H06429, KAKENHI-PLANNED-18H05501, KAKENHI-PROJECT-18H02619, KAKENHI-PROJECT-17K19560, KAKENHI-PROJECT-19K22968, KAKENHI-PLANNED-16H06575, KAKENHI-PUBLICLY-19H04837, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-18K06937, KAKENHI-PLANNED-18H05498, KAKENHI-PROJECT-16H06276, KAKENHI-ORGANIZER-18H05497
[Journal Article] Ribosomal protein S7 ubiquitination during ER stress in yeast is associated with selective mRNA translation and stress outcome2020
- Author(s)
  Matsuki Yasuko、Matsuo Yoshitaka、Nakano Yu、Iwasaki Shintaro、Yoko Hideyuki、Udagawa Tsuyoshi、Li Sihan、Saeki Yasushi、Yoshihisa Tohru、Tanaka Keiji、Ingolia Nicholas T.、Inada Toshifumi
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 19669-19669
- DOI
  10.1038/s41598-020-76239-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06481, KAKENHI-PROJECT-20K06490, KAKENHI-PUBLICLY-19H05281, KAKENHI-PROJECT-18H03977, KAKENHI-PROJECT-19H00997, KAKENHI-PLANNED-18H05498, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-17H04998, KAKENHI-PROJECT-19K22406, KAKENHI-PLANNED-20H05784
[Journal Article] Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation2020
- Author(s)
  A. Nishiyama, C. Mulholland, S. Bultmann, S. Kori, A. Endo, Y. Saeki, W. Qin, C. Trummer, Y. Chiba, H. Yokoyama, S. Kumamoto, T. Kawakami, H. Hojo, G. Nagae, H. Aburatani, K. Tanaka, K. Arita, H. Leonhardt, M. Nakanishi
- Journal Title
  
  Nat. Commun.
  
  Volume: 11 Issue: 1 Pages: 1222-1222
- DOI
  10.1038/s41467-020-15006-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05316, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05498, KAKENHI-PUBLICLY-19H05285, KAKENHI-PLANNED-19H05744, KAKENHI-PROJECT-18H03993, KAKENHI-PROJECT-18H02392, KAKENHI-PROJECT-19H03153, KAKENHI-PROJECT-19J22030, KAKENHI-PLANNED-19H05740, KAKENHI-PROJECT-17H01398, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-18K07963, KAKENHI-ORGANIZER-19H05739
[Journal Article] A substrate-trapping strategy to find E3 ubiquitin ligase substrates identifies Parkin and TRIM28 targets2020
- Author(s)
  Watanabe Masashi、Saeki Yasushi、Takahashi Hidehisa、Ohtake Fumiaki、Yoshida Yukiko、Kasuga Yusuke、Kondo Takeshi、Yaguchi Hiroaki、Suzuki Masanobu、Ishida Hiroki、Tanaka Keiji、Hatakeyama Shigetsugu
- Journal Title
  
  Communications Biology
  
  Volume: 3 Issue: 1 Pages: 592-592
- DOI
  10.1038/s42003-020-01328-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22408, KAKENHI-PUBLICLY-19H05280, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-18H02378, KAKENHI-PROJECT-18H02607, KAKENHI-PROJECT-19K22401, KAKENHI-PLANNED-18H05498, KAKENHI-PROJECT-17H03986, KAKENHI-ORGANIZER-18H05497
[Journal Article] Stress- and ubiquitylation-dependent phase separation of the proteasome2020
- Author(s)
  Yasuda Sayaka、Tsuchiya Hikaru、Kaiho Ai、Guo Qiang、Ikeuchi Ken、Endo Akinori、Arai Naoko、Ohtake Fumiaki、Murata Shigeo、Inada Toshifumi、Baumeister Wolfgang、Fernandez-Busnadiego Ruben、Tanaka Keiji、Saeki Yasushi
- Journal Title
  
  Nature
  
  Volume: 578 Issue: 7794 Pages: 296-300
- DOI
  10.1038/s41586-020-1982-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05498, KAKENHI-PLANNED-18H05500, KAKENHI-PUBLICLY-19H05281, KAKENHI-PROJECT-18H03993, KAKENHI-PROJECT-18H04022, KAKENHI-PROJECT-18K14913, KAKENHI-PROJECT-26000014, KAKENHI-PROJECT-17H03986, KAKENHI-PROJECT-19H00997
[Journal Article] Loss of Parkin contributes to mitochondrial turnover and dopaminergic neuronal loss in aged mice.2020
- Author(s)
  Noda S, Sato S, Fukuda T, Tada N, Uchiyama Y, Tanaka K, Hattori N.
- Journal Title
  
  Neurobiol Dis.
  
  Volume: 136 Pages: 104717-104717
- DOI
  10.1016/j.nbd.2019.104717
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07850, KAKENHI-PROJECT-19K22603, KAKENHI-PROJECT-18H04043, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-19K23782
[Journal Article] The HOIL-1L ligase modulates immune signalling and cell death via monoubiquitination of LUBAC2020
- Author(s)
  Fuseya Yasuhiro、Fujita Hiroaki、Kim Minsoo、Ohtake Fumiaki、Nishide Akira、Sasaki Katsuhiro、Saeki Yasushi、Tanaka Keiji、Takahashi Ryosuke、Iwai Kazuhiro
- Journal Title
  
  Nature Cell Biology
  
  Volume: 22 Issue: 6 Pages: 663-673
- DOI
  10.1038/s41556-020-0517-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16144, KAKENHI-PLANNED-18H05499, KAKENHI-PROJECT-17H06174, KAKENHI-PROJECT-19H00997, KAKENHI-PLANNED-18H05498, KAKENHI-PUBLICLY-20H05319, KAKENHI-PROJECT-17H03986, KAKENHI-ORGANIZER-18H05497, KAKENHI-PROJECT-19K06635, KAKENHI-PUBLICLY-20H05505
[Journal Article] The PINK1-Parkin axis: An Overview.2020
- Author(s)
  Tanaka K.
- Journal Title
  
  Neurosci Res.
  
  Volume: S0168-0102 Pages: 30571-1
- DOI
  10.1016/j.neures.2020.01.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-26000014
[Journal Article] Thymoproteasome and peptidic self2019
- Author(s)
  Takahama Y, Ohigashi I, Murata S, Tanaka K.
- Journal Title
  
  Immunogenetics
  
  Volume: 71 Issue: 3 Pages: 217-221
- DOI
  10.1007/s00251-018-1081-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08884, KAKENHI-PROJECT-16H02630, KAKENHI-PROJECT-25221102, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-26000014
[Journal Article] Detection of ubiquitination activity and identification of ubiquitinated substrates using TR-TUBE2019
- Author(s)
  Yoshida, Y., Saeki, Y., Tsuchiya, H., and Tanaka, K.
- Journal Title
  
  Methods Enzymol
  
  Volume: 618 Pages: 135-147
- DOI
  10.1016/bs.mie.2018.12.032
- ISBN
  9780128163597
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K14913, KAKENHI-ORGANIZER-18H05497, KAKENHI-PROJECT-18H03993, KAKENHI-PROJECT-16K07705, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-19H02926, KAKENHI-PROJECT-26000014
[Journal Article] Parkin recruitment to impaired mitochondria for nonselective ubiquitylation is facilitated by MITOL2019
- Author(s)
  Koyano Fumika、Yamano Koji、Kosako Hidetaka、Tanaka Keiji、Matsuda Noriyuki
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 294 Issue: 26 Pages: 10300-10314
- DOI
  10.1074/jbc.ra118.006302
- NAID
  120006959752
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08635, KAKENHI-PROJECT-18K06237, KAKENHI-PROJECT-18K14708, KAKENHI-PLANNED-18H05500, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-26000014, KAKENHI-PROJECT-18H02443
[Journal Article] Trans-omics impact of thymoproteasome in cortical thymic epithelial cells.2019
- Author(s)
  Ohigashi I, Tanaka Y, Kondo K, Fujimori S, Kondo H, Palin A, Hoffmann V, Kozai M, Matsushita Y, Uda S, Motosugi R, Hamazaki J, Kubota H, Murata S, Tanaka K, Katagiri T, Kosako H, Takahama Y
- Journal Title
  
  Cell Reports
  
  Volume: 29 Issue: 9 Pages: 2901-2916
- DOI
  10.1016/j.celrep.2019.10.079
- NAID
  120006894616
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07062, KAKENHI-PLANNED-17H06419, KAKENHI-PUBLICLY-18H04801, KAKENHI-PLANNED-18H05500, KAKENHI-PROJECT-16H02630, KAKENHI-PROJECT-18H04022, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-18H02431, KAKENHI-PROJECT-17K08884, KAKENHI-PROJECT-26000014, KAKENHI-PLANNED-16H06577
[Journal Article] Parkin‐mediated ubiquitylation redistributes MITOL/March5 from mitochondria to peroxisomes2019
- Author(s)
  Koyano Fumika、Yamano Koji、Kosako Hidetaka、Kimura Yoko、Kimura Mayumi、Fujiki Yukio、Tanaka Keiji、Matsuda Noriyuki
- Journal Title
  
  EMBO reports
  
  Volume: 20 Issue: 12
- DOI
  10.15252/embr.201947728
- NAID
  120006942558
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08635, KAKENHI-PROJECT-18K06237, KAKENHI-PROJECT-18K14708, KAKENHI-PLANNED-18H05500, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-17H03675, KAKENHI-PROJECT-26000014, KAKENHI-PLANNED-19H05712, KAKENHI-PROJECT-18H02443
[Journal Article] Structural insights into ubiquitin recognition and Ufd1 interaction of Npl42019
- Author(s)
  Sato Yusuke、Tsuchiya Hikaru、Yamagata Atsushi、Okatsu Kei、Tanaka Keiji、Saeki Yasushi、Fukai Shuya
- Journal Title
  
  Nature Communications
  
  Volume: 10 Issue: 1 Pages: 5708-5708
- DOI
  10.1038/s41467-019-13697-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05498, KAKENHI-PLANNED-18H05501, KAKENHI-PROJECT-18H03993, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-19H03162, KAKENHI-PROJECT-18K14913, KAKENHI-PROJECT-26000014
[Journal Article] Methods to measure ubiquitin chain length and linkage.2019
- Author(s)
  Ohtake, F., Tsuchiya, H., Tanaka, K., and Saeki, Y.
- Journal Title
  
  Methods Enzymol
  
  Volume: 618 Pages: 105-133
- DOI
  10.1016/bs.mie.2018.12.019
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K14913, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05498, KAKENHI-PROJECT-18H03993, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-17H03986, KAKENHI-PROJECT-16K14702
[Journal Article] Collided ribosomes form a unique structural interface to induce Hel2‐driven quality control　pathways2019
- Author(s)
  Ikeuchi Ken、Tesina Petr、Matsuo Yoshitaka、Sugiyama Takato、Cheng Jingdong、Saeki Yasushi、Tanaka Keiji、Becker Thomas、Beckmann Roland、Inada Toshifumi
- Journal Title
  
  The EMBO Journal
  
  Volume: 38 Issue: 5
- DOI
  10.15252/embj.2018100276
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-INTERNATIONAL-15K21743, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05498, KAKENHI-PLANNED-26116003, KAKENHI-PROJECT-18H03993, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-26000014
[Journal Article] Sugar-Recognizing Ubiquitin Ligases: Action Mechanisms and Physiology.2019
- Author(s)
  Yoshida Y, Mizushima T, Tanaka K.
- Journal Title
  
  Front Physiol.
  
  Volume: 10 Pages: 104-104
- DOI
  10.3389/fphys.2019.00104
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07705, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-19H02926, KAKENHI-PROJECT-26000014
[Journal Article] Endosomal Rab cycles regulate Parkin-mediated mitophagy.2018
- Author(s)
  Yamano K, Wang C, Sarraf SA, Münch C, Kikuchi R, Noda NN, Hizukuri Y, Kanemaki MT, Harper W, Tanaka K, Matsuda N, Youle RJ.
- Journal Title
  
  eLife
  
  Volume: 7
- DOI
  10.7554/elife.31326
- NAID
  120006457172
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15091, KAKENHI-PLANNED-25111004, KAKENHI-PROJECT-16K15095, KAKENHI-PROJECT-16K18545, KAKENHI-PROJECT-26000014, KAKENHI-PUBLICLY-18H04719, KAKENHI-PROJECT-18H02170, KAKENHI-PROJECT-18H02443
[Journal Article] Structural insights into ubiquitin phosphorylation by PINK12018
- Author(s)
  Okatsu Kei、Sato Yusuke、Yamano Koji、Matsuda Noriyuki、Negishi Lumi、Takahashi Akiko、Yamagata Atsushi、Goto-Ito Sakurako、Mishima Masaki、Ito Yutaka、Oka Toshihiko、Tanaka Keiji、Fukai Shuya
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 10382-10382
- DOI
  10.1038/s41598-018-28656-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05887, KAKENHI-PUBLICLY-17H05888, KAKENHI-PLANNED-18H05501, KAKENHI-PROJECT-16H04749, KAKENHI-PROJECT-16H04750, KAKENHI-PROJECT-17H03676, KAKENHI-PROJECT-18H02443, KAKENHI-PROJECT-26000014
[Journal Article] Loss of autophagy in dopaminergic neurons causes Lewy pathology and motor dysfunction in aged mice.2018
- Author(s)
  Sato S, Uchihara T, Fukuda T, Noda S, Kondo H, Saiki S, Komatsu M, Uchiyama Y, Tanaka K, Hattori N.
- Journal Title
  
  Sci Rep.
  
  Volume: ８ Issue: 1 Pages: 2813-2813
- DOI
  10.1038/s41598-018-21325-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06780, KAKENHI-PROJECT-17K07797, KAKENHI-PROJECT-16K14572, KAKENHI-PLANNED-25111006, KAKENHI-PLANNED-25111007, KAKENHI-PROJECT-15H04842, KAKENHI-PROJECT-15H04843, KAKENHI-PROJECT-17H03555, KAKENHI-PROJECT-26000014, KAKENHI-PROJECT-18H04043
[Journal Article] K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains.2018
- Author(s)
  Ohtake, F., Tsuchiya, H., Saeki, Y., and Tanaka, K
- Journal Title
  
  PNAS
  
  Volume: 115 Issue: 7 Pages: 1401-1408
- DOI
  10.1073/pnas.1716673115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K14702, KAKENHI-PROJECT-26293018, KAKENHI-PROJECT-17H03986, KAKENHI-PROJECT-26000014
[Journal Article] HERC2 facilitates BLM and WRN helicase complex interaction with RPA to suppress G-quadruplex DNA.2018
- Author(s)
  Wu, W., Rokutanda, N., Takeuchi, J., Lai, Y., Maruyama, R., Togashi, Y., Nishikawa, H., Arai, N., Miyoshi, Y., Suzuki, N., Saeki, Y., Tanaka, K., and Ohta, T.
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  Cancer Res.
  
  Volume: 78 Pages: 6371-6385
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26000014
[Journal Article] Accelerated invagination of vacuoles as a stress response in chronically heat-stressed yeasts.2018
- Author(s)
  Ishii, A., Kawai, K., Noda, H., Kato, H., Takeda, K., Asakawa, K., Ichikawa, Y., Sasanami, T., Tanaka, K., and Kimura, Y.
- Journal Title
  
  Sci Rep.
  
  Volume: 8 Issue: 1 Pages: 2-644
- DOI
  10.1038/s41598-018-20781-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26000014, KAKENHI-PROJECT-17H03902
[Journal Article] Ub-ProT reveals global length and composition of protein ubiquitylation in cells2018
- Author(s)
  Tsuchiya, H., Burana, D., Ohtake, F., Arai, N., Kaiho, A., Komada, M., Tanaka,K., and Saeki, Y.
- Journal Title
  
  Nature Commun
  
  Volume: 9 Issue: 1 Pages: 524-524
- DOI
  10.1038/s41467-018-02869-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K14702, KAKENHI-PROJECT-26293018, KAKENHI-PUBLICLY-17H05681, KAKENHI-PROJECT-17H03986, KAKENHI-PROJECT-26000014
[Journal Article] Reactive oxygen species up-regulate expression of muscle atrophy-associated ubiquitin ligase Cbl-b in rat L6 skeletal muscle cells.2018
- Author(s)
  Yuushi Okumura et al.
- Journal Title
  
  Am J Physiol Cell Physiol.
  
  Volume: 印刷中 Issue: 6 Pages: C721-C731
- DOI
  10.1152/ajpcell.00184.2017
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09585, KAKENHI-PLANNED-15H05937, KAKENHI-PROJECT-15H04931, KAKENHI-PROJECT-15J40096, KAKENHI-PROJECT-26000014, KAKENHI-PROJECT-18K08453, KAKENHI-PLANNED-15H05936, KAKENHI-PUBLICLY-18H04981, KAKENHI-ORGANIZER-15H05935
[Journal Article] Cytosolic N-Glycans : Triggers for Ubiquitination Directing Proleasomal and Autophagic Degradation : Molecular Systems for Monitoring Cytosolic N-Glycans as Signals for Unwanted Proteins and Organelles.2018
- Author(s)
  Yoshida, Y. and Tanaka, K.
- Journal Title
  
  BioEssays
  
  Volume: 40 Issue: 3
- DOI
  10.1002/bies.201700215
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26000014, KAKENHI-PROJECT-16K07705
[Journal Article] The immunoproteasome and thymoproteasome: functions, evolution and human disease2018
- Author(s)
  Murata S, Takahama Y, Kasahara M, Tanaka K
- Journal Title
  
  Nature Immunol.
  
  Volume: 19 Issue: 9 Pages: 923-931
- DOI
  10.1038/s41590-018-0186-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-18H05497, KAKENHI-PROJECT-16H02630, KAKENHI-PROJECT-25221102, KAKENHI-PROJECT-26000014
[Journal Article] Ubiquitination of stalled ribosome triggers ribosome-associated quality control2017
- Author(s)
  Matsuo Y, Ikeuchi K, Saeki Y, Iwasaki S, Schmidt C, Udagawa T, Sato F, Tsuchiya H, Becker T, Tanaka K, Ingolia NT, Beckmann R, Inada T
- Journal Title
  
  Nature Communications
  
  Volume: 8 Issue: 1 Pages: 159-159
- DOI
  10.1038/s41467-017-00188-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07243, KAKENHI-PROJECT-26293018, KAKENHI-PLANNED-26116003, KAKENHI-PROJECT-16K18486, KAKENHI-PROJECT-26000014, KAKENHI-PUBLICLY-17H05679, KAKENHI-PROJECT-17H04998
[Journal Article] In Vivo Ubiquitin Linkage-type Analysis Reveals that the Cdc48-Rad23/Dsk2 Axis Contributes to K48-linked Chain Specificity of the Proteasome in Yeast.2017
- Author(s)
  Tsuchiya, H., Ohtake, F., Arai, N., Kaiho, A., Yasuda, S., Tanaka, K., and Saeki, Y.
- Journal Title
  
  Mol Cell
- Description
  【掲載確定】 in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26000014
[Journal Article] In vivo ubiquitin linkage-type analysis reveals that the Cdc48-Rad23/Dsk2 axis contributes to K48-linked chain specificity of the proteasome.2017
- Author(s)
  Tsuchiya, H., Ohtake, F., Arai, N., Kaiho, A., Yasuda, S., Tanaka, K., and Saeki, Y.
- Journal Title
  
  Mol. Cell
  
  Volume: 66 Issue: 4 Pages: 488-502
- DOI
  10.1016/j.molcel.2017.04.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293018, KAKENHI-PROJECT-26000014
[Journal Article] Crystal structure of human proteasome assembly chaperone PAC4 involved in proteasome formation2017
- Author(s)
  Eiji Kurimoro, Tadashi Satoh, Yuri Ito, Eri Ishihara, Kenta Okamoto, Maho Yagi-Utsumi, Keiji Tanaka, and Koichi Kato
- Journal Title
  
  Protein Sci.
  
  Volume: 26 Issue: 5 Pages: 1080-1085
- DOI
  10.1002/pro.3153
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H02491, KAKENHI-PROJECT-15K21680, KAKENHI-PROJECT-17K15441, KAKENHI-ORGANIZER-25102001, KAKENHI-PLANNED-25102008, KAKENHI-PROJECT-26000014
[Journal Article] Ubiquitination of exposed glycoproteins by SCFFBXO27 directs damaged lysosomes for autophagy.2017
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  Yoshida Y, Yasuda S, Fujita T, Hamasaki M, Murakami A, Kawawaki J, Iwai K, Saeki Y, Yoshimori T, Matsuda N, Tanaka K
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  Proc. Natl. Acad. Sci. USA
  
  Volume: 114 Issue: 32 Pages: 8574-8579
- DOI
  10.1073/pnas.1702615114
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07705, KAKENHI-WRAPUP-17H06078, KAKENHI-PLANNED-25111002, KAKENHI-PROJECT-17H06174, KAKENHI-PROJECT-15H04371, KAKENHI-PROJECT-26000014
[Journal Article] Purkinje Cells Are More Vulnerable to the Specific Depletion of Cathepsin D Than to That of Atg72017
- Author(s)
  Koike Masato、Shibata Masahiro、Sunabori Takehiko、Yamaguchi Junji、Sakimura Kenji、Komatsu Masaaki、Tanaka Keiji、Uchiyama Yasuo
- Journal Title
  
  The American Journal of Pathology
  
  Volume: 187 Issue: 7 Pages: 1586-1600
- DOI
  10.1016/j.ajpath.2017.02.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08522, KAKENHI-PROJECT-17K19444, KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-25000015, KAKENHI-PROJECT-26000014
[Journal Article] Structural basis for specific cleavage of Lys6-linked polyubiquitin chains by USP302017
- Author(s)
  Sato Yusuke、Okatsu Kei、Saeki Yasushi、Yamano Koji、Matsuda Noriyuki、Kaiho Ai、Yamagata Atsushi、Goto-Ito Sakurako、Ishikawa Minoru、Hashimoto Yuichi、Tanaka Keiji、Fukai Shuya
- Journal Title
  
  Nature Structural & Molecular Biology
  
  Volume: 24 Issue: 11 Pages: 911-919
- DOI
  10.1038/nsmb.3469
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15072, KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26293018, KAKENHI-PROJECT-16H04749, KAKENHI-PROJECT-16H04750, KAKENHI-PROJECT-15J10559, KAKENHI-PROJECT-16K18545, KAKENHI-PROJECT-26000014
[Journal Article] A human PSMB11 variant affects thymoproteasome processing and CD8+ T cell production2017
- Author(s)
  Ohigashi I, Ohte Y, Setoh K, Nakase H, Maekawa A, Kiyonari H, Hamazaki Y, Sekai M, Sudo T, Tabara Y, Sawai H, Omae Y, Yuliwulandari R, Tanaka Y, Mizokami M, Inoue H, Kasahara M, Minato N, Tokunaga K, Tanaka K, Matsuda F, Murata S, Takahama Y.
- Journal Title
  
  JCI Insight
  
  Volume: 2 Issue: 10 Pages: 1-14
- DOI
  10.1172/jci.insight.93664
- NAID
  120006733720
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08884, KAKENHI-PROJECT-15K19125, KAKENHI-PUBLICLY-15H01154, KAKENHI-PLANNED-24111008, KAKENHI-PROJECT-16H02630, KAKENHI-PROJECT-17H04123, KAKENHI-PROJECT-15K15151, KAKENHI-PROJECT-26000014, KAKENHI-PROJECT-15H04716
[Journal Article] Foxn1-β5t transcriptional axis controls CD8+ T cell production in the thymus.2017
- Author(s)
  Uddin MM, Ohigashi I, Motosugi R, Nakayama T, Sakata M, Hamazaki J, Nishito Y, Rode I, Tanaka K, Takemoto T, Murata S, Takahama Y.
- Journal Title
  
  Nat Commun
  
  Volume: 8 Issue: 1 Pages: 14419-14419
- DOI
  10.1038/ncomms14419
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111004, KAKENHI-PROJECT-25221102, KAKENHI-PROJECT-16H02630, KAKENHI-PROJECT-15K19130, KAKENHI-PROJECT-16K08228, KAKENHI-PROJECT-26000014
[Journal Article] HTLV-1 Tax induces formation of the active macromolecular IKK complex by generating Lys63- and Met1-linked hybrid polyubiquitin chains.2017
- Author(s)
  Shibata Y, Tokunaga F, Goto E, Komatsu G, Gohda J, Saeki Y, Tanaka K, Takahashi H, Sawasaki T, Inoue S, Oshiumi H, Seya T, Nakano H, Tanaka Y, Iwai K, and Inoue J.
- Journal Title
  
  PLoS Pathog.
  
  Volume: 13 Issue: 12 Pages: e1006162-e1006162
- DOI
  10.1371/journal.ppat.1006162
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01172, KAKENHI-PUBLICLY-15H01553, KAKENHI-PUBLICLY-16H01192, KAKENHI-PLANNED-16H06575, KAKENHI-PLANNED-16H06579, KAKENHI-PLANNED-24112002, KAKENHI-PLANNED-24112008, KAKENHI-PLANNED-26110003, KAKENHI-PROJECT-15H04694, KAKENHI-PROJECT-16H04729, KAKENHI-PROJECT-26290036, KAKENHI-PROJECT-15K15353, KAKENHI-PROJECT-15K18468, KAKENHI-PROJECT-15K08517, KAKENHI-PROJECT-16K01378, KAKENHI-PROJECT-16K15210, KAKENHI-PROJECT-26000014
[Journal Article] Parkinson’s disease-related DJ-1 functions in thiol quality control against aldehyde attack in vitro2017
- Author(s)
  Matsuda Noriyuki、Kimura Mayumi、Queliconi Bruno Barros、Kojima Waka、Mishima Masaki、Takagi Kenji、Koyano Fumika、Yamano Koji、Mizushima Tsunehiro、Ito Yutaka、Tanaka Keiji
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 12816-12816
- DOI
  10.1038/s41598-017-13146-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H00847, KAKENHI-PUBLICLY-17H05887, KAKENHI-PUBLICLY-17H05888, KAKENHI-PROJECT-15H04339, KAKENHI-PROJECT-16F15387, KAKENHI-PROJECT-17J03737, KAKENHI-PROJECT-15K14494, KAKENHI-PROJECT-16K18545, KAKENHI-PROJECT-26000014
[Journal Article] Inhibitory effects of local anesthetics on the proteasome and their biological actions2017
- Author(s)
  Bahrudin, U.; Unno, M.; Nishio, K.; Kita, A.; Li, P.; Kato, M.; Inoue, M.; Tsujitani, S.; Murakami, T.; Sugiyama, R.; Saeki, Y.; Obara, Y.; Tanaka, K.; Yamaguchi, H.; Sakane, I.; Kawata, Y.; Itoh, T.; Ninomiya, H.; Hisatome, I.; Morimoto, Y.
- Journal Title
  
  Sci. Rep.
  
  Volume: 7 Issue: 1 Pages: 5079-5079
- DOI
  10.1038/s41598-017-04652-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26241030, KAKENHI-PROJECT-15K08277, KAKENHI-PROJECT-26000014
[Journal Article] A novel approach to assess the ubiquitin-fold modifier 1-system in cells.2017
- Author(s)
  Ishimura R, Obata M, Kageyama S, Daniel J, Tanaka K, Komatsu M.
- Journal Title
  
  FEBS Lett.
  
  Volume: 591 Issue: 1 Pages: 196-204
- DOI
  10.1002/1873-3468.12518
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-16J07037, KAKENHI-PROJECT-26000014
[Journal Article] Atg9a deficiency causes axon-specific lesions including neuronal circuit dysgenesis.2017
- Author(s)
  Yamaguchi J, Suzuki C, Nanao T, Kakuta S, Ozawa K, Tanida I, Saitoh T, Sunabori T, Komatsu M, Tanaka K, Aoki S, Sakimura K, Uchiyama Y.
- Journal Title
  
  Autophagy
  
  Volume: 17 Issue: 5 Pages: 1-14
- DOI
  10.1080/15548627.2017.1314897
- NAID
  120006881392
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K12749, KAKENHI-PROJECT-17K19444, KAKENHI-PROJECT-26713005, KAKENHI-PUBLICLY-17H05533, KAKENHI-PUBLICLY-17H06009, KAKENHI-PLANNED-17H06415, KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-26461277, KAKENHI-PROJECT-25000015, KAKENHI-PROJECT-26000014, KAKENHI-PROJECT-17K15550, KAKENHI-PROJECT-16H04650
[Journal Article] Structure of the Dnmt1 reader module complexed with a unique two-mono-ubiquitin mark on histone H3 reveals the basis for DNA methylation maintenance.2017
- Author(s)
  Ishiyama S, Nishiyama A, Saeki Y, Moritsugu K Morimoto D, Yamaguchi L, Arai N, Matsumura R, Kawakami T, Mishima Y, Hojo H, Shimamura S, Ishikawa F, Tajima S, Tanaka K, Ariyoshi M, Shirakawa M, Ikeguchi M, Kidera A, Suetake I, Arita K, Nakanishi M
- Journal Title
  
  Mol Cell
  
  Volume: 68 Issue: 2 Pages: 350-360
- DOI
  10.1016/j.molcel.2017.09.037
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K14418, KAKENHI-PROJECT-16K14714, KAKENHI-PROJECT-16K18503, KAKENHI-PROJECT-26293018, KAKENHI-PLANNED-26119004, KAKENHI-PROJECT-16H04180, KAKENHI-PROJECT-16H04780, KAKENHI-PROJECT-16H04818, KAKENHI-PROJECT-15K05565, KAKENHI-PROJECT-15K18520, KAKENHI-PROJECT-26000014
[Journal Article] The ubiquitin signal and autophagy : an orchestrated dance leading to mitochondrial degradation2016
- Author(s)
  Koji Yamano, K., Matsuda, N., and Tanaka, K.
- Journal Title
  
  EMBO Rep.
  
  Volume: 17 Issue: 3 Pages: 300-3016
- DOI
  10.15252/embr.201541486
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26000014, KAKENHI-PUBLICLY-15H01196
[Journal Article] Structural analysis of a function-associated loop mutant of the substrate recognition domain of Fbs1 ubiquitin ligase.2016
- Author(s)
  Nishio, K., Yoshida, Y., Tanaka, K., Mizushima, T.
- Journal Title
  
  Acta Crystallographica Section F
  
  Volume: 72 Issue: 8 Pages: 619-626
- DOI
  10.1107/s2053230x16011018
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-24112009, KAKENHI-PROJECT-26000014
[Journal Article] p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming2016
- Author(s)
  Saito T, Ichimura Y, Taguchi K, Suzuki T, Mizushima T, Takagi K, Hirose Y, Nagahashi M, Iso T, Fukutomi T, Ohishi M, Endo K, Uemura T, Nishito Y, Okuda S, Obata M, Kouno T, Imamura R, Tada Y, Obata R, Yasuda D, Takahashi K, Fujimura T, Pi J, Lee MS, Ueno T, Ohe T, Mashino T, Wakai T, Kojima H, Okabe T, Nagano T et al.
- Journal Title
  
  Nature Commun
  
  Volume: 7 Issue: 1 Pages: 12030-12030
- DOI
  10.1038/ncomms12030
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01190, KAKENHI-PLANNED-24112009, KAKENHI-PLANNED-25111006, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-26242088, KAKENHI-PROJECT-26253019, KAKENHI-PROJECT-15H04670, KAKENHI-PROJECT-15H04692, KAKENHI-PROJECT-16H05137, KAKENHI-PROJECT-26460354, KAKENHI-PROJECT-26460384, KAKENHI-PROJECT-16K15228, KAKENHI-PROJECT-26830080, KAKENHI-PROJECT-16K10565, KAKENHI-PROJECT-15KK0325, KAKENHI-PROJECT-26000014
[Journal Article] Biallelic Variants in UBA5 Link Dysfunctional UFM1 Ubiquitin-like Modifier Pathway to Severe Infantile-Onset Encephalopathy.2016
- Author(s)
  Muona M, Ishimura R, Laari A,...... , Komatsu M.
- Journal Title
  
  Am J Hum Genet.
  
  Volume: 99 Issue: 3 Pages: 683-94
- DOI
  10.1016/j.ajhg.2016.06.020
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-16H05137, KAKENHI-PROJECT-16J07037, KAKENHI-PROJECT-26830080, KAKENHI-PROJECT-15K18373, KAKENHI-PROJECT-26000014
[Journal Article] The Ankrd13 family of ubiquitin-interacting motif-bearing proteins regulates valosin-containing protein/p97 protein-mediated lysosomal trafficking of caveolin I.2016
- Author(s)
  Burana, D., Yoshihara, H., Tanno, H., Yamamoto, A., Saeki, Y., Tanaka, K., and Komada, M.
- Journal Title
  
  J Biol Chem.
  
  Volume: 291 Pages: 6218-6231
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26000014
[Journal Article] Unexpected mitochondrial matrix localization of Parkinson's disease-related DJ-1 mutants but not wild type DJ-1.2016
- Author(s)
  Kojima, W., Kujuro, Y., Okatsu, K., Bruno, Q., Koyano, F., Kimura, M., Yamano, K., Tanaka, K., and Matsuda, N.
- Journal Title
  
  Genes to Cells
  
  Volume: 21 Issue: 7 Pages: 772-788
- DOI
  10.1111/gtc.12382
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01196, KAKENHI-PROJECT-26000014
[Journal Article] Essential role of specialized proteasome subunits in thymic selection of CD8 T cells2016
- Author(s)
  Kincaid, E. Z. Murata, S., Tanaka, K., and Rock, K. L.
- Journal Title
  
  Nat Immunol
- Description
  【掲載確定】 in press
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26000014
[Journal Article] Ankrd13 family of ubiquitin-interacting motif-bearing proteins regulates VCP/p97-mediated lysosomal traffic of caveolin-1.2016
- Author(s)
  Burana, D., Yoshihara, H., Tanno, H., Yamamoto, A., Saeki, Y., Tanaka, K., and Komada, M.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 291 Issue: 12 Pages: 6218-6231
- DOI
  10.1074/jbc.m115.710707
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-24112003, KAKENHI-PROJECT-15H04293, KAKENHI-PROJECT-26000014, KAKENHI-PLANNED-24112008
[Journal Article] p62/Sqstml promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming.2016
- Author(s)
  Saito, T., Ichimura, Y., Taguchi, K., Suzuki, T., Mizushima, T., Takagi, K., Hirose, Y., Nagahashi, M., Iso, T., Fukutomi, T., Ohishi, M., Endo, K., Uemura, T., Nishito, Y., Okuda, S., Obata, M., Kouno, T., Imamura, R., Tada, Y., Obata, R., Yasuda, D., Takahashi, K., Fujimura, T., Pi, J., Lee, M-S., Ueno, T., Ohe, T., Mashino, T., Wakai, T., Kojima, H., Okabe, T., Nagano, T., Motohashi, H., Waguri, S., Soga, T., Yamamoto, M., Tanaka, K., and Komatsu, M.
- Journal Title
  
  Nat Commun.
- Description
  【掲載確定】 in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26000014
[Journal Article] The K48-K63 branched ubiquitin chain regulates NF-kappaB signaling2016
- Author(s)
  Ohtake F, Saeki Y, Ishido S, Kanno J, Tanaka K
- Journal Title
  
  Mol. Cell
  
  Volume: 64 Issue: 2 Pages: 251-266
- DOI
  10.1016/j.molcel.2016.09.014
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-24112003, KAKENHI-PLANNED-24112008, KAKENHI-PROJECT-26000014, KAKENHI-PLANNED-24112004, KAKENHI-PROJECT-16K14702
[Journal Article] The E3 ubiquitin ligase TRIM23 regulates adipocyte differentiation via stabilization of the adipocyte activator PPAR gamma.2015
- Author(s)
  Watanabe, M., Takahashi, H., Saeki, Y., Ozaki, T., Itoh, S., Suzuki, M., Mizushima, W., Tanaka, K. and Hatakeyama, S.
- Journal Title
  
  eLIFE
  
  Volume: 4
- DOI
  10.7554/elife.05615
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25860201, KAKENHI-PROJECT-15K15058, KAKENHI-PLANNED-24112006, KAKENHI-PLANNED-24112008, KAKENHI-PLANNED-24118002, KAKENHI-PROJECT-15H04690, KAKENHI-PROJECT-15H04701, KAKENHI-PROJECT-26670130, KAKENHI-PROJECT-26000014
[Journal Article] TCR affinity for thymoproteasome-dependent positively selecting peptides conditions antigen responsiveness in CD8(+) T cells2015
- Author(s)
  Takada K, Van Laethem F, Xing Y, Akane K, Suzuki H, Murata S, Tanaka K, Jameson SC, Singer A, Takahama Y.
- Journal Title
  
  Nature Immunology
  
  Volume: 16 Issue: 10 Pages: 1069-1076
- DOI
  10.1038/ni.3237
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460576, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111004, KAKENHI-PROJECT-25221102, KAKENHI-PROJECT-26000014
[Journal Article] Thymoproteasomes produce unique peptide motifs for positive selection of CD8(+) T cells.2015
- Author(s)
  Sasaki K, Takada K, Ohte Y, Kondo H, Sorimachi H, Tanaka K, Takahama Y, Murata S.
- Journal Title
  
  Nature Communications
  
  Volume: 6 Issue: 1 Pages: 7484-7484
- DOI
  10.1038/ncomms8484
- NAID
  120006999409
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460576, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111004, KAKENHI-PROJECT-25221102, KAKENHI-PROJECT-14J12345, KAKENHI-PROJECT-26000014
[Journal Article] Mutations in the deubiquitinase gene USP8 cause Cushing’s disease2015
- Author(s)
  Reincke M, Sbiera S, Hayakawa A, Theodoropoulou M, Osswald A, Beuschlein F, Meitinger T, Mizuno-Yamasaki E, Kawaguchi K, Saeki Y, Tanaka K, Wieland T, Graf E, Saeger W, Ronchi CL, Allolio B, Buchfelder M, Strom TM, Fassnacht M & Komada M
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  Nat. Genet.
  
  Volume: 47 Issue: 1 Pages: 31-38
- DOI
  10.1038/ng.3166
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-24112003, KAKENHI-PLANNED-24112008, KAKENHI-PROJECT-26000014
[Journal Article] Nedd4-induced mono-ubiquitination of IRS-2 enhances IGF signaling and mitogenic activity.2015
- Author(s)
  Toshiaki Fukushima, Hidehito Yoshihara, Haruka Furuta, Fumihiko Hakuno, Jing Luan, Cunming Duan, Yasushi Saeki, Keiji Tanaka, Shun-Ichiro Iemura, TohruNatsume, Kazuhiro Chida, Yusuke Nakatsu, Hideaki Kamata, Tomoichiro Asano, and Shin-Ichiro Takahashi
- Journal Title
  
  Nature communications
  
  Volume: 6 Issue: 1 Pages: 6780-6780
- DOI
  10.1038/ncomms7780
- NAID
  120006348510
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23370062, KAKENHI-PROJECT-24380152, KAKENHI-PROJECT-24657092, KAKENHI-PROJECT-24790928, KAKENHI-PROJECT-25850220, KAKENHI-PROJECT-26460369, KAKENHI-PUBLICLY-15H01382, KAKENHI-PUBLICLY-15H01406, KAKENHI-PLANNED-24112008, KAKENHI-ORGANIZER-24115001, KAKENHI-PLANNED-24115007, KAKENHI-PROJECT-25221204, KAKENHI-PROJECT-15H04583, KAKENHI-PROJECT-26000014
[Journal Article] The unexpected role of polyubiquitin chains in the formation of fibrillar aggregates.2015
- Author(s)
  Morimoto D,Walinda E, Fukada H, Sou YS, Kageyama S, Hoshino M, Fujii T, Tsuchiya H, Saeki Y, Arita K, Ariyoshi M, Tochio H, Iwai K, Namba K, Komatsu M, Tanaka K, Shirakawa M.
- Journal Title
  
  Nat Commun.
  
  Volume: 6 Issue: 1 Pages: 6116-6116
- DOI
  10.1038/ncomms7116
- NAID
  120005528125
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-21121006, KAKENHI-ORGANIZER-24112001, KAKENHI-PLANNED-24112002, KAKENHI-PLANNED-24112008, KAKENHI-PROJECT-25000013, KAKENHI-PLANNED-25111006, KAKENHI-PUBLICLY-25112514, KAKENHI-PLANNED-26119004, KAKENHI-PROJECT-26440025, KAKENHI-PROJECT-26860224, KAKENHI-PROJECT-25253019, KAKENHI-PROJECT-26000014
[Journal Article] Conserved Mode of Interaction between Yeast Bro1 Family V Domains and YP(X)nL Motif-Containing Target Proteins2015
- Author(s)
  Yoko Kimura, Mirai Tanigawa, Junko Kawawaki, Kenji Takagi, Tsunehiro Mizushima, Tatsuya Maeda, Keiji Tanaka
- Journal Title
  
  Eukaryotic Cell
  
  Volume: 14 Issue: 10 Pages: 976-982
- DOI
  10.1128/ec.00091-15
- NAID
  120005671359
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26440070, KAKENHI-PLANNED-24112009, KAKENHI-PROJECT-25291042, KAKENHI-PROJECT-26000014
[Journal Article] Thymoproteasomes produce unique peptide motifs for positive selection of CD8+ T cells2015
- Author(s)
  Katsuhiro Sasakil, Kensuke Takada, Yuki Ohte, Hiroyuki Kondo, Hiroyuki Sorimachi, Keiji Tanaka, Yousuke Takahama, Shigeo Murata
- Journal Title
  
  Nat Commun. in press
- NAID
  120006999409
- Description
  印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26000014
[Journal Article] Site-specific Interaction Mapping of Phosphorylated Ubiquitin to Uncover Parkin Activation.2015
- Author(s)
  Koji Yamano, Bruno B. Queliconi, Fumika Koyano, Yasushi Saeki, Takatsugu Hirokawa, Keiji Tanaka§,and Noriyuki Matsuda
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 290 Issue: 42 Pages: 25199-25211
- DOI
  10.1074/jbc.m115.671446
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K19037, KAKENHI-PUBLICLY-15H01196, KAKENHI-PLANNED-24112008, KAKENHI-PUBLICLY-26111729, KAKENHI-PROJECT-26650042, KAKENHI-PROJECT-26000014
[Journal Article] Ubiquitin acetylation inhibits polyubiquitin chain elongation.2015
- Author(s)
  Ohtake F, Saeki Y, Sakamoto K, Ohtake K, Nishikawa H, Tsuchiya H, Ohta T, Tanaka K, Kanno J.
- Journal Title
  
  EMBO Rep.
  
  Volume: 16 Issue: 2 Pages: 192-201
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  10.15252/embr.201439152
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-24112005, KAKENHI-PLANNED-24112008, KAKENHI-PROJECT-26290042, KAKENHI-PROJECT-26291035, KAKENHI-PROJECT-26670730, KAKENHI-PROJECT-26870853, KAKENHI-PLANNED-24112004, KAKENHI-PROJECT-26000014
[Journal Article] Parkin receptor on damaged mitochondria revisited -uncovering the role of phosphorylated ubiquitin chain2015
- Author(s)
  Matsuda, N. and Tanaka, K.
- Journal Title
  
  Autophagy
  
  Volume: 11 Issue: 9 Pages: 1700-1701
- DOI
  10.1080/15548627.2015.1071760
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26000014
[Journal Article] The Structural Differences between a Glycoprotein Specific F-Box Protein Fbs1 and Its Homologous Protein FBG3.2015
- Author(s)
  Kumanomidou T, Nishio K, Takagi K, Nakagawa T, Suzuki A, Yamane T, Tokunaga F, Iwai K, Murakami A, Yoshida Y, Tanaka K, Mizushima T.
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  PLoS One.
  
  Volume: 10 Issue: 10 Pages: e0140366-e0140366
- DOI
  10.1371/journal.pone.0140366
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08259, KAKENHI-PUBLICLY-15H01172, KAKENHI-PLANNED-24112009, KAKENHI-PROJECT-15H04694, KAKENHI-PROJECT-26000014, KAKENHI-PLANNED-24112002, KAKENHI-PROJECT-25253019
[Journal Article] Measurement of proteasome activity in peripheral blood mononuclear cells as an indicator of susceptibility to bortezomib-induced severe neurological adverse events in patients with multiple myeloma2015
- Author(s)
  Cho, Y., Hori, M., Okoshi, Y., Fujisawa, F., Shinagawa, A., Kudo, D., Komeno, T., Yoshida, C., Katsura, Y., Ota, I., Shimizu, S., Kamoshita, M., Sasaki, K., Tanaka, K., Mukai, H. Y., and Kojima, H.
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  Acta Haematol.
  
  Volume: 134 Issue: 1 Pages: 25-31
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  10.1159/000369445
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26000014
[Journal Article] Phosphorylated ubiquitin chain is the genuine Parkin receptor.2015
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  K. Okatsu, F. Koyano, M. Kimura, H. Kosako, Y. Saeki, K. Tanaka and N. Matsuda
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  The Journal of Cell Biology
  
  Volume: 209 Issue: 1 Pages: 111-128
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  10.1083/jcb.201410050
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26440101, KAKENHI-PROJECT-15K19037, KAKENHI-PUBLICLY-15H01196, KAKENHI-PLANNED-24112008, KAKENHI-PUBLICLY-26111729, KAKENHI-PROJECT-26650042, KAKENHI-PROJECT-26000014
[Journal Article] A comprehensive method for detecting ubiquitinated substrates using TR-TUBE2015
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  Yoshida, Y., Saeki, Y., Murakami, A., Kawawaki, J., Tsuchiya, H., Yoshihara, H., Shindo, M., and Tanaka, K.
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  Proc. Natl. Acad. Sci. USA.
  
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  10.1073/pnas.1422313112
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  KAKENHI-PLANNED-24112008, KAKENHI-PROJECT-26000014
[Journal Article] Unconventional PINK1 localization mechanism to the outer membrane of depolarized mitochondria drives Parkin recruitment2015
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  Okatsu, K., Kimura, M., Oka, T., Tanaka, K., and Matsuda N.
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  J Cell Sci
  
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  10.1242/jcs.161000
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- Data Source
  KAKENHI-PROJECT-26000014, KAKENHI-PROJECT-26440106, KAKENHI-PUBLICLY-15H01196, KAKENHI-PUBLICLY-26111729, KAKENHI-PROJECT-26650042
[Journal Article] Tagged tags engage disposal2015
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  Matsuda, N. and Tanaka, K.
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  Nature (News and Views)
  
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  10.1038/nature15199
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- Data Source
  KAKENHI-PROJECT-26000014
[Journal Article] Liganded ERα stimulates the E3 ubiquitin ligase activity of UBE3C to facilitate cell proliferation2015
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  Okada M, Ohtake F, Nishikawa H, Wu W, Saeki Y, Takana K, Ohta T
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  Molecular Endocrinology
  
  Volume: 29 Issue: 11 Pages: 1646-1657
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  10.1210/me.2015-1125
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460402, KAKENHI-PLANNED-24112005, KAKENHI-PLANNED-24112008, KAKENHI-PUBLICLY-26102741, KAKENHI-PROJECT-26670730, KAKENHI-PROJECT-26290042, KAKENHI-PROJECT-26000014
[Journal Article] Modification of ASC1 by UFM1 is crucial for ERα transactivation and breast cancer development.2014
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  Yoo, HM., Kang, SH., Kim, JY., Lee, JE., Seong, MW., Lee, SW., Ka, SH., Sou,YS., Komatsu, M., Tanaka, K., Lee, ST., Noh, DY., Baek, SH., Jeon, YJ., *Chung, CH.
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  Mol. Cell
  
  Volume: 56 Issue: 2 Pages: 261-274
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  10.1016/j.molcel.2014.08.007
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-26000014, KAKENHI-PROJECT-26650012
[Journal Article] LC3B is indispensable for selective autophagy of p62 but not basal autophagy.2014
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  Maruyama Y, Sou YS, Kageyama S, Takahashi T, Ueno T, Tanaka K, Komatsu M, Ichimura Y.
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  Biochem Biophys Res Commun.
  
  Volume: 446 Issue: 1 Pages: 309-315
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  10.1016/j.bbrc.2014.02.093
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790332, KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-25460400, KAKENHI-PROJECT-26000014
[Journal Article] Dissection of the role of p62/Sqstml in activation of Nrf2 during xenophagy.2014
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  Ishimura, R., Tanaka, K., and Komatsu, M.
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  FEBS Lett.
  
  Volume: 588 Issue: 5 Pages: 822-828
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  10.1016/j.febslet.2014.01.045
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- Data Source
  KAKENHI-PROJECT-21000012, KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-26000014
[Journal Article] The ESCRT-III adaptor protein Brol controls functions of regulator for free ubiauitin chains 1 (Rful) in ubiquitin homeostasis2014
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  Kimura Y, Kawawaki J, Kakiyama Y, Shimoda A, and Tanaka K
- Journal Title
  
  J Biol Chem
  
  Volume: 289 Issue: 31 Pages: 21760-21769
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  10.1074/jbc.m114.550871
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26000014, KAKENHI-PROJECT-26440070
[Journal Article] The significant role of autophagy in the granular layer in normal skin differentiation and hair growth.2014
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  Yoshihara, N., Ueno, T., Takagi, A., Trejo, JA., Haruna, K., Suga, Y., Komatsu, M., Tanaka, K., *Ikeda, S.
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  Arch. Dermatol. Res.
  
  Volume: 307 Issue: 2 Pages: 159-169
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  10.1007/s00403-014-1508-0
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- Data Source
  KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-26000014, KAKENHI-PROJECT-26860897
[Journal Article] Quantitative live-cell imaging reveals spatiotemporal dynamics and cytoplasmic assembly of the 26S proteasome2014
- Author(s)
  Pack, Chan-Gi., Yukii, H., Toh-e, A., Kudo, T., Tsuchiya, H., Kaiho, A., Sakata, E., Murata, S., Yokosawa, H., Sako, Y., Baumeister, W., Tanaka, K., and Saeki, Y
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  Nat Commun.
  
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- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Ubiquitin is phosphorylated by PINK1 to activate parkin.2014
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  Koyano, F., Okatsu, K., Kosako, H., Tamura, Y., Go, E., Kimura, M., Kimura, Y., Tsuchiya, H., Yoshihara, H., Hirokawa, T., Endo, T., Fon. E. A., Trempe, J. F., Saeki, Y., Tanaka, K., and Matsuda, N.
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  Nature
  
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  10.1038/nature13392
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- Data Source
  KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-23570231, KAKENHI-PLANNED-24112008, KAKENHI-PROJECT-24657072, KAKENHI-PUBLICLY-25112522, KAKENHI-PROJECT-25870311, KAKENHI-PROJECT-26000014, KAKENHI-PUBLICLY-26111729, KAKENHI-PROJECT-26440070, KAKENHI-PROJECT-26440101, KAKENHI-PROJECT-26650042, KAKENHI-PROJECT-22227003
[Journal Article] Ubiquitin is phosphorylated by PINK1 to activate parkin2014
- Author(s)
  Koyano,F., Okatsu, K., Kosako, H., Tamura, Y., Go, E., Kimura, M., Kimura, Y., Tsuchiya, H., Yoshihara, H., Hirokawa, T., Endo, T., Fon. E.A., Trempe, J.F., Saeki, Y., Tanaka, K., and Matsuda, N.
- Journal Title
  
  Nature
  
  Volume: 510 Pages: 162-166
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- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Proteasome dysfunction activates autophagy and the Keap1-Nrf2 pathway2014
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  Kageyama S, Sou YS, Uemura T, Kametaka S, Saito T, Ishimura R, Kouno T, Bedford L, Mayer RJ, Lee MS, Yamamoto M, Waguri S, Tanaka K, and Komatsu M.
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  J Biol Chem
  
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  10.1074/jbc.m114.580357
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- Data Source
  KAKENHI-PROJECT-24249015, KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-26000014, KAKENHI-PROJECT-26253019, KAKENHI-PROJECT-26830080, KAKENHI-PROJECT-26860224
[Journal Article] Pba3-Pba4 heterodimer acts as a molecular matchmaker in proteasome α-ring formation2014
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  Takagi, K., Saeki, Y., Yashiroda, H., Yagi, H., Kaiho, A., Murata, S., Yamane, T., Tanaka, K., Mizushima, T. and Kato, K.
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  Biochem. Biophys. Res. Commun.
  
  Volume: 450 Issue: 2 Pages: 1110-1114
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  10.1016/j.bbrc.2014.06.119
- Peer Reviewed / Acknowledgement Compliant
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  KAKENHI-PLANNED-24112008, KAKENHI-PROJECT-24570208, KAKENHI-ORGANIZER-25102001, KAKENHI-PLANNED-25102008, KAKENHI-PROJECT-25870631, KAKENHI-PROJECT-26000014, KAKENHI-PROJECT-26293018
[Journal Article] Tongue pressure as a novel biomarker of spinal and bulbar muscular atrophy (SBMA)2014
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  Mano T, Katsuno M, Banno H, Suzuki K, Suga N, Hashizume A, Araki A, Watanabe H, Tanaka S, Yamamoto M, Sobue G
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  Neurology
  
  Volume: 82 Issue: 3 Pages: 255-262
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  10.1212/wnl.0000000000000041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229011, KAKENHI-PLANNED-22110005, KAKENHI-PROJECT-23390230, KAKENHI-PROJECT-24659428
[Journal Article] Quantitative live-cell imaging reveals spatio-temporal dynamics and cytoplasmic assembly of the 26S proteasome2014
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  Pack, CG., Yukii, H.,　Toh-e, A., Kudo, T., Tsuchiya, H., Kaiho, A., Sakata, E., Murata, S., Sako, Y., Baumeister, W., Tanaka, K., and Saeki, Y.
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  Nature Commun
  
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  10.1038/ncomms4396
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  KAKENHI-PLANNED-24112008, KAKENHI-PROJECT-24657097, KAKENHI-PROJECT-25221102, KAKENHI-PROJECT-26000014
[Journal Article] PARK2/Parkin-mediated mitochondrial clearance contributes to proteasome activation during slow-twitch muscle atrophy via NFE2L1 nuclear translocation.2014
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  Autophagy
  
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  10.4161/auto.27785
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  KAKENHI-PLANNED-23111003, KAKENHI-PROJECT-23592350, KAKENHI-PROJECT-24390224, KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-25350901, KAKENHI-PROJECT-25670426, KAKENHI-PROJECT-26000014
[Journal Article] Backbone 1H, 13C, and 15N assignments of yeast Ump1, an intrinsically disordered protein that functions as a proteasome assembly chaperone2014
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  Y.Uekusa, K.Okawa, M.Yagi-Utsumi, O.Serve, Y. Nakagawa, T.Mizushima, H.Yagi, Y.Saeki, K.Tanaka, and K.Kato
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  Biomol. NMR Assign.
  
  Volume: 8 Issue: 2 Pages: 383-386
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  10.1007/s12104-013-9523-1
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-25102001, KAKENHI-PLANNED-25102008, KAKENHI-PROJECT-26000014
[Journal Article] Structural Basis for Proteasome Formation Controlled by an Assembly Chaperone Nas22014
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  Satoh T, Saeki Y, Hiromoto T, Wang YH, Uekusa Y, Yagi H, Yoshihara H, Yagi-Utsumi M, Mizushima T, Tanaka K, Kato K
- Journal Title
  
  Structure
  
  Volume: (掲載確定) Issue: 5 Pages: 731-743
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  10.1016/j.str.2014.02.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J07852, KAKENHI-PROJECT-21000012, KAKENHI-PLANNED-24112008, KAKENHI-PROJECT-24657097, KAKENHI-PROJECT-24657113, KAKENHI-PROJECT-24770102, KAKENHI-ORGANIZER-25102001, KAKENHI-PLANNED-25102008, KAKENHI-PUBLICLY-25121730, KAKENHI-PROJECT-26000014
[Journal Article] Quantitative live-cell imagingreveals moleculardynamics andcytoplasmic assembly ofthe 26Sproteasome2014
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  Pack, Chan-Gi., Yukii, H., Toh-e, A., Kudo,T., Tsuchiya, H., Kaiho, A., Sakata, E., Murata, S., Yokosawa, H., Sako, Y., Baumeister, W., Tanaka, K., and Saeki, Y.
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  Nat Commun.
  
  Volume: 2014
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  KAKENHI-PROJECT-21000012
[Journal Article] Translational research on disease-modifying therapies for neurodegenerative diseases2013
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  Neurology and Clinical Neuroscience
  
  Volume: 1 Issue: 1 Pages: 3-10
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  10.1002/ncn3.7
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- Data Source
  KAKENHI-PROJECT-21229011, KAKENHI-PROJECT-24659428
[Journal Article] Defective immune responses in mice lacking LUBAC-mediated linear ubiquitination in B cells2013
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  Sasaki, Y., Sano, S., Nakahara, M., Murata, S., Kometani, K., Aiba, Y., Sakamoto, S., Watanabe, Y., Tanaka, K., Kurosaki, T., and lwai, K.
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  EMBO J.
  
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  10.1038/emboj.2013.184
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  KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-21229007, KAKENHI-ORGANIZER-24112001, KAKENHI-PLANNED-24112002, KAKENHI-PROJECT-24659136, KAKENHI-PROJECT-25221102, KAKENHI-PROJECT-25253019
[Journal Article] A dimeric PINK1-containing complex on depolarized mitochondria stimulates Parkin recruitment2013
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  Kei Okatsu, Midori Uno, Fumika Koyano, Etsu Go, Mayumi kimura, Toshihiko Oka, Keiji Tanaka, Noriyuki Matsuda
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  The Journal of Biological Chemistry
  
  Volume: 288 Issue: 51 Pages: 36372-84
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  10.1074/jbc.m113.509653
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J06061, KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-23570232, KAKENHI-PROJECT-23687018, KAKENHI-PUBLICLY-24111557, KAKENHI-PUBLICLY-25112522
[Journal Article] A multi-purpose fusion tag derived from an unstructured and hyper-acidic region of the amyloid precursor protein.2013
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  Sangawa, Tabata, S., Suzuki, K., Saeki, Y., Tanaka, K., and Takagi, J.
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  Protein Science in press
  
  Volume: in press
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- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Aire-expressing thymic medullary epithelial cells originate from β5t-expressing progenitor cells.2013
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  Ohigashi, I., Zuklys, S., Sakata, M., Mayer, GE., Zhanybekova. S., Murata, S., Tanaka, K., Hollander, G., and Takahama, Y.
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  Proc Natl Acad Sci USA
  
  Volume: 110 Issue: 24 Pages: 9885-9890
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  10.1073/pnas.1301799110
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- Data Source
  KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-23249025, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111004, KAKENHI-PROJECT-25221102, KAKENHI-PROJECT-25860361
[Journal Article] The parallel reaction monitoring method contributes to highly sensitive polyubiquitin chain quantification2013
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  Hikaru Tsuchiya1, Keiji Tanaka1*, and Yasushi Saeki1*
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  Biochem Biophys Res Commun. in press. (*cocorespondences)
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Aire-expressing thymic medullary epithelial cells originate from β5t-expressing progenitor cells.2013
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  Ohigashi, I., Zuklys, S., Sakata, M., Mayer, GE., Zhanybekova. S., Murata, S., Tanaka, K., Hollander, G., and Takahama, Y.
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  Proc Natl Acad Sci USA in press.
  
  Volume: in press
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  KAKENHI-PROJECT-21000012
[Journal Article] A dimeric PINK1-containing complex on depolarized mitochondria stimulates Parkin recruitment2013
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  OkatsuK, Uno M, Koyano F,Go E, KimuraM, Oka T,Tanaka K, Matsuda N.
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  J. Biol. Chem.
  
  Volume: 288 Pages: 36372-36384
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  KAKENHI-PROJECT-21000012
[Journal Article] Proteostasis and neurodegeneration: the roles of proteasomal degradation and autophagy.2013
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  Tanaka, K., and Matsuda, N.
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  Biochim. Biophys. Acta Molecular Cell Research in press
  
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- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Heat shock factor-1 influences pathological lesion distribution of polyglutamine-induced neurodegeneration2013
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  Kondo N, Katsuno M, Adachi H, Minamiyama M, Doi H, Matsumoto S, Miyazaki Y, Iida M, Tohnai G, Nakatsuji H, Ishigaki S, Fujioka Y, Watanabe H, Tanaka F, Nakai A, Sobue G
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  Nat Commun
  
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  10.1038/ncomms2417
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  KAKENHI-PROJECT-21229011, KAKENHI-PROJECT-23390230, KAKENHI-PROJECT-24659428, KAKENHI-PLANNED-22110005
[Journal Article] Parkin catalyzed ubiquitin-ester transfer is triggered by PINK1-dependent phosphorylation2013
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  Masahiro Iguchi, Yuki Kujuro, Kei Okatsu, Fumika Koyano, Hidetaka Kosako, Mayumi Kimura, Norihiro Suzuki, Shinichiro Uchiyama, Keiji Tanaka, Noriyuki Matsuda
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  The Journal of Biological Chemistry
  
  Volume: 288 Issue: 30 Pages: 22019-32
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  10.1074/jbc.m113.467530
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  KAKENHI-PROJECT-11J06061, KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-23570231, KAKENHI-PROJECT-23687018, KAKENHI-PUBLICLY-24111557, KAKENHI-PUBLICLY-25112522, KAKENHI-PROJECT-25860721
[Journal Article] Proteostasis and neurodegeneration : the roles of proteasomal degradation and autophagy.2013
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  Tanaka, K. and Matsuda, N.
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  Biochim. Biophys. Acta (Molecular Cell Research)
  
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  10.1016/j.bbamcr.2013.03.012
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- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] The principal PINK1 and Parkin cellular events triggered in response to dissipation of mitochondrial membrane potential occur in primary neurons.2013
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  Koyano, F., Okatsu, K., Ishigaki, S., Fujioka, Y., Kimura, M., Sobue, G., Tanaka, K.* and Matsuda, N*
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  Genes Cells in press. (*cocorespondences)
  
  Volume: in press
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- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] A multi-purpose fusion tag derived from an unstructured and hyper-acidic region of the amyloid precursor protein.2013
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  Sangawa, T., Tabata, S., Suzuki, K., Saeki, Y., Tanaka, K., and Takagi, J.
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  Protein Science
  
  Volume: 22 Issue: 6 Pages: 840-850
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  10.1002/pro.2254
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  KAKENHI-PROJECT-21000012, KAKENHI-ORGANIZER-24111001, KAKENHI-PROJECT-24651260, KAKENHI-PROJECT-24657097, KAKENHI-PLANNED-24112008
[Journal Article] Cytoplasmic proteasomes are not indispensable for cell growth in Saccharomyces cerevisiae2013
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  Hikaru Tsuchiya1, Naoko Arai1, Keiji Tanaka1*, and Yasushi Saeki1*
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  Biochem Biophys Res Commun. in press. (*cocorespondences)
  
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  KAKENHI-PROJECT-21000012
[Journal Article] Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.2013
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  Ichimura, Y., Waguri, S., Sou, Y., Kageyama, S., Hasegawa, J., Ishimura, R., Saito, T., Yang, Y., Kouno, T., Fukutomi, T., Hoshii, T., Atsushi, H., Takagi, K., Mizushima, T., Motohashi, H., Lee, M-S., Yoshimori, T., Tanaka, K., Yamamoto, M., and Komatsu, K.
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  Mol Cell
  
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  10.1016/j.molcel.2013.08.003
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  KAKENHI-PROJECT-21000012, KAKENHI-PLANNED-23116002, KAKENHI-PROJECT-23247034, KAKENHI-PLANNED-24112009, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24390075, KAKENHI-PROJECT-24790332, KAKENHI-PROJECT-24790967, KAKENHI-PLANNED-25111002, KAKENHI-PUBLICLY-25118710, KAKENHI-PROJECT-25460400, KAKENHI-PROJECT-25870631
[Journal Article] Distinct acoustic features in spinal and bulbar muscular atrophy patients with laryngospasm.2013
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  Tanaka S, Banno H, Katsuno M, Suzuki K, Suga N, Hashizume A, Mano T, Araki A, Watanabe H, Adachi H, Tatsumi H, Yamamoto M, Sobue G.
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  J Neurol Sci.
  
  Volume: 337 Issue: 1-2 Pages: 193-200
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  10.1016/j.jns.2013.12.010
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[Journal Article] Spatial arrangement and functional role of α subunits of proteasome activator PA28 in hetero-oligomeric form.2013
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  Sugiyama, M., Sahashi, H., Kurimoto, E., Takata, S., Yagi, H., Kanai, K., Sakata, E., Minami, Y., Tanaka, K., and Kato K.
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  Biochem Biophys Res Commun.
  
  Volume: 432 Issue: 1 Pages: 141-145
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  10.1016/j.bbrc.2013.01.071
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  KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-24657113, KAKENHI-PLANNED-20107004
[Journal Article] The proteasome : from basic mechanisms to emerging roles.2013
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  Keio J Med.
  
  Volume: 62 Pages: 1-12
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[Journal Article] The proteasome: from basic mechanisms to emerging roles.2013
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  Tanaka, K.
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  Keio J. Med.
  
  Volume: 62 Pages: 1-12
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  10031160102
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[Journal Article] Involvement of Bag6 and theTRC pathwayin proteasome assembly2013
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  Akahane, T., Sahara, K., Yashiroda, H., Tanaka, K., andMurata, S.
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  Nat Commun.
  
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[Journal Article] p62/SQSTM1 differentially removes the toxic mutant androgen receptor via autophagy and inclusion formation in a spinal and bulbar muscular atrophy mouse model2013
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  Doi H, Adachi H, Katsuno M, Minamiyama M, Matsumoto S, Kondo N, Miyazaki Y, IidaM,Tohnai G, Qiang Q, Tanaka F, Yanagawa T, WarabiE,Ishii T, Sobue G
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  J Neurosci
  
  Volume: 33 Issue: 18 Pages: 7710-7727
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  10.1523/jneurosci.3021-12.2013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229011, KAKENHI-PLANNED-22110005, KAKENHI-PROJECT-23390230, KAKENHI-PROJECT-23390231, KAKENHI-PROJECT-24659428, KAKENHI-PROJECT-25220103
[Journal Article] Parkin catalyzed ubiquitin-ester transfer is triggered by PINK1-dependent phosphorylation2013
- Author(s)
  Iguchi, M., Kujuro, Y., Okatsu, K., Koyano, F., Kosako, H., Kimura, M., Suzuki, N., Uchiyama, S., Tanaka, K., and Matsuda, N.
- Journal Title
  
  J Biol Chem
  
  Volume: 288 Pages: 22019-22032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Phosphorylation ofp62 activatesthe Keap1-Nrf2 pathway duringselective autophagy2013
- Author(s)
  Ichimura, Y., Waguri, S., Sou, Y., Kageyama, S., Hasegawa, J., Ishimura, R., Saito, T.,Yang, Y., Kouno, T., Fukutomi, T., Hoshii, T.,Atsushi, H., Takagi, K., Mizushima, T., Motohashi, H., Lee, M-S., Yoshimori, T., Tanaka, K., Yamamoto, M., and Komatsu, K.
- Journal Title
  
  Mol Cell
  
  Volume: 51 Pages: 618-631
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Cytoplasmic proteasomes are not indispensable for cell growth in Saccharomyces cerevisiae.2013
- Author(s)
  Tsuchiya, H., Arai, N., Tanaka, K., and Saeki, Y.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 436 Issue: 3 Pages: 372-376
- DOI
  10.1016/j.bbrc.2013.05.105
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] The parallel reaction monitoring method contributes to highly sensitive polyubiquitin chain quantification.2013
- Author(s)
  Tsuchiya, H., Tanaka, K., and Saeki, Y.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 436 Issue: 2 Pages: 223-229
- DOI
  10.1016/j.bbrc.2013.05.080
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-24657097
[Journal Article] Endogenous nitrated nucleotide is a key mediator of autophagy and innate defense against bacteria.2013
- Author(s)
  Ito C, Saito Y, Nozawa T, Fujii S, Sawa T, Inoue H, Matsunaga T, Khan S, Akashi S, Hashimoto R, Aikawa C, Takahashi E, Sagara H, Komatsu M, Tanaka K, Akaike T, Nakagawa I, Arimoto H.
- Journal Title
  
  Mol. Cell
  
  Volume: 52 Issue: 6 Pages: 794-804
- DOI
  10.1016/j.molcel.2013.10.024
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-11F01105, KAKENHI-PROJECT-12J06857, KAKENHI-ORGANIZER-20117001, KAKENHI-PLANNED-20117005, KAKENHI-PLANNED-20117006, KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-24390082, KAKENHI-PROJECT-24590527, KAKENHI-PROJECT-24790413, KAKENHI-PUBLICLY-25125708, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-25253020, KAKENHI-PROJECT-25282236, KAKENHI-PROJECT-25293370, KAKENHI-PROJECT-25305013, KAKENHI-PROJECT-25670775
[Journal Article] The principal PINK1 and Parkin cellular events triggered in response to dissipation of mitochondrial membrane potential also occur in primary neurons2013
- Author(s)
  Fumika Koyano, Kei Okatsu, Shinsuke Ishigaki, Yusuke Fujioka, Mayumi Kimura, Keiji Tanaka, Noriyuki Matsuda
- Journal Title
  
  Genes to Cells
  
  Volume: 18 Issue: 8 Pages: 672-81
- DOI
  10.1111/gtc.12066
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J06061, KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-23687018, KAKENHI-PUBLICLY-24111557, KAKENHI-PUBLICLY-25112522
[Journal Article] Different dynamic movements of wild-type and pathogenic VCPs and the ir cofactors to damaged mitochondria in a Parkin-mediated mitochondrial quality control system2013
- Author(s)
  Yoko Kimura, Junpei Fukushi, Seiji Hori, Noriyuki Matsuda, Kei Okatsu, Yukie Kakiyama, Junko Kawawaki, Akira Kakizuka, Keiji Tanaka
- Journal Title
  
  Genes to Cells
  
  Volume: 18 Issue: 12 Pages: 1131-43
- DOI
  10.1111/gtc.12103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J06061, KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-23249016, KAKENHI-PROJECT-23570184
[Journal Article] Mitochondrial hexokinase HKI is a novel substrate of the Parkin ubiquitin ligase.2012
- Author(s)
  Okatsu, K., Iemura, S., Koyano, F., Go, E., Kimura, M., Natsume, T., Tanaka, K., and Matsuda, N.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 428 Pages: 197-202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Proteasomal degradation resolves competition between cell polarization and cellular wound healing.2012
- Author(s)
  Kono, K., Saeki, Y., Yoshida, S., Tanaka, K., and Pellman, D.
- Journal Title
  
  Cell
  
  Volume: 150 Pages: 151-164
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Thymic nurse cells do not nurse most T cells but support TCR revision in cortical thymocytes.2012
- Author(s)
  Nakagawa, Y., Ohigashi, I., Nitta, T., Tanaka, K., Murata, S., Sakata, M., and Takahama, Y.
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 109 Pages: 20572-20577
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis.2012
- Author(s)
  Tashiro, Y., Urushitani, M., Inoue, H., Koike, M., Uchiyama, Y., Komatsu, M., Tanaka, K., Yamazaki, M., Abe, M., Misawa. H., Sakimura, K., Ito, H., and Takahashi, R.
- Journal Title
  
  J. Biol, Chem.
  
  Volume: 287 Pages: 42984-42994
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] β5t-containing thymoproteasome : thymic cortical epithelial cell-specific expression and role in positive selection of CD8^+ T cells2012
- Author(s)
  Takahama, Y., Takada, K., Murata, S., Tanaka, K.
- Journal Title
  
  Curr.Opini.Immunol.
  
  Volume: 24 Pages: 92-98
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Smad7-deficient mice show growth retardation with reduced viability2012
- Author(s)
  Tojo M, Takebe A, Takahashi S, Tanaka K, Imamura T, Miyazono K, Chiba T
- Journal Title
  
  J Biochem.
  
  Volume: (in press) Issue: 6 Pages: 621-631
- DOI
  10.1093/jb/mvs022
- NAID
  10031166104
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012, KAKENHI-PLANNED-22112002, KAKENHI-PROJECT-23570221
[Journal Article] Discrimination of spinal and bulbar muscular atrophy from amyotrophic lateral sclerosis using sensory nerve action potentials.2012
- Author(s)
  Hama T, Hirayama M, Hara T, Nakamura T, Atsuta N, Banno H, Suzuki K, Katsuno M, Tanaka F, Sobue G.
- Journal Title
  
  Muscle Nerve
  
  Volume: 45 Issue: 2 Pages: 169-174
- DOI
  10.1002/mus.22291
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229011, KAKENHI-PROJECT-21600003, KAKENHI-PLANNED-22110005, KAKENHI-PROJECT-23390230, KAKENHI-PROJECT-23790986, KAKENHI-PROJECT-24500458
[Journal Article] Viral delivery of miR-196a ameliorates the SBMA phenotype via the silencing of CELF22012
- Author(s)
  Miyazaki Y, Adachi H, Katsuno M, Minamiyama M, Jiang YM, Huang Z, Doi H, Matsumoto S, Kondo N, Iida M, Tohnai G, Tanaka F, Muramatsu S, Sobue G
- Journal Title
  
  Nat Med
  
  Volume: 18 Issue: 7 Pages: 1136-1141
- DOI
  10.1038/nm.2791
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229011, KAKENHI-PROJECT-23390231, KAKENHI-PROJECT-23590473, KAKENHI-PUBLICLY-23110515
[Journal Article] The proteasome : molecular machinery and pathophysiological roles2012
- Author(s)
  Tanaka, K., Mizushima, T., Saeki, Y.
- Journal Title
  
  Biol Chem.
  
  Volume: 393 Issue: 4 Pages: 217-234
- DOI
  10.1515/hsz-2011-0285
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012, KAKENHI-PUBLICLY-23121525, KAKENHI-PROJECT-23657080
[Journal Article] Assembly and function of the proteasome.2012
- Author(s)
  Saeki, Y and Tanaka, K.
- Journal Title
  
  Methods Mol Biol
  
  Volume: 832 Pages: 315-337
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Proteasomal degradation resolves competition between cell polarization and cellular wound healing2012
- Author(s)
  Kono, K., Saeki, Y., Yoshida, S., Tanaka, K., Pellman, D.
- Journal Title
  
  Cell
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Naratriptan mitigates CGRP1-associated motor neuron degeneration caused by expanded polyglutamine2012
- Author(s)
  Minamiyama M, Katsuno M, Adachi H, Doi H, Kondo N, Iida M, Ishigaki S, Fujioka Y, Matsumoto S, Miyazaki Y, Tanaka F, Kurihara H, Sobue G
- Journal Title
  
  Nat Med
  
  Volume: 18 Issue: 10 Pages: 1531-1538
- DOI
  10.1038/nm.2932
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229011, KAKENHI-PUBLICLY-23013007, KAKENHI-PROJECT-23390230, KAKENHI-PROJECT-23659107, KAKENHI-PROJECT-24249047
[Journal Article] Differential change of clinical outcome measures in spinal and bulbar muscular atrophy: comparison of natural history with placebo-treated group.2012
- Author(s)
  Hashizume A, Katsuno M, Banno H, Suzuki K, Suga N, Tanaka F, Sobue G.
- Journal Title
  
  J Neurol.
  
  Volume: 259 Issue: 4 Pages: 712-719
- DOI
  10.1007/s00415-011-6251-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229011, KAKENHI-PLANNED-22110005, KAKENHI-PROJECT-23390230, KAKENHI-PROJECT-23790986
[Journal Article] The proteasome : from basic mechanisms to emerging roles2012
- Author(s)
  Tanaka, K.
- Journal Title
  
  Keio J.Med.
  
  Volume: (in press)
- NAID
  10031160102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Defective axonal transport in motor neuron diseases.2012
- Author(s)
  Ikenaka K, Katsuno M, Kawai K, Ishigaki S, Tanaka F, Sobue G.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 13 Issue: 1 Pages: 1225-1238
- DOI
  10.3390/ijms13011225
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229011, KAKENHI-PLANNED-22110005, KAKENHI-PROJECT-23390230
[Journal Article] Structural basis for specific recognition of Rpt1, an ATPase subunit of the 26S proteasome, by the proteasome-dedicated chaperone Hsm32012
- Author(s)
  Takagi, K., Kim, S., Yukii, H., Ueno, M., Morishita , R., Endo, Y., Kato, K., K., Tanaka, K., Saeki, Y., and Mizushima, Y.
- Journal Title
  
  J Biol Chem.
  
  Volume: 287 Pages: 12172-12182
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Current status of treatment of spinal and bulbar muscular atrophy2012
- Author(s)
  Tanaka F, Katsuno M, Banno H, Suzuki K, Adachi H, Sobue G
- Journal Title
  
  Neural Plast
  
  Volume: 2012 Pages: 369284-369284
- DOI
  10.1155/2012/369284
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229011, KAKENHI-PROJECT-23790986, KAKENHI-PROJECT-24659428
[Journal Article] Molecular pathophysiology and disease-Modifying therapies for spinal and bulbar muscular atrophy2012
- Author(s)
  Katsuno M, Banno H, Suzuki K, Adachi H, Tanaka F, Sobue G
- Journal Title
  
  Arch Neurol
  
  Volume: 69 Issue: 4 Pages: 436-440
- DOI
  10.1001/archneurol.2011.2308
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229011, KAKENHI-PLANNED-22110005, KAKENHI-PROJECT-23390230, KAKENHI-PROJECT-23790986, KAKENHI-PROJECT-24659428
[Journal Article] Decreased proteasomal activity causes age-related phenotypes and promotes the development of metabolic abnormalities.2012
- Author(s)
  Tomaru U, Takahashi S, Ishizu A, Miyatake Y, Gohda A, Suzuki S, Ono A, Ohara J, Baba T, Murata S, Tanaka K, and Kasahara M.
- Journal Title
  
  Am. J. Pathol.
  
  Volume: 180 Pages: 963-972
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Cross-sectional and longitudinal analysis of an oxidative stress biomarker for spinal and bulbar muscular atrophy.2012
- Author(s)
  Mano, T., Katsuno, M., Banno, H., Suzuki, K., Suga, N., Hashizume, A., Tanaka, F., Sobue, G.
- Journal Title
  
  Muscle Nerve
  
  Volume: 46 Issue: 5 Pages: 692-697
- DOI
  10.1002/mus.23413
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229011, KAKENHI-PROJECT-23390230, KAKENHI-PROJECT-23790986
[Journal Article] Perspectives on molecular targeted therapies and clinical trials for neurodegenerative diseases2012
- Author(s)
  Katsuno M, Tanaka F, Sobue G
- Journal Title
  
  J Neurol Neurosurg Psychiatry
  
  Volume: 83 Issue: 3 Pages: 329-335
- DOI
  10.1136/jnnp-2011-301307
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229011, KAKENHI-PLANNED-22110005, KAKENHI-PROJECT-23390230, KAKENHI-PROJECT-24659428
[Journal Article] Oxidative stress induced by glutathione depletion reproduces pathological modifications of TDP-43 linked to TDP-43 proteinopathies.2012
- Author(s)
  Iguchi Y,Katsuno M,Takagi S.Ishigaki S,Niwa JI,Hasegawa M,Tanaka F,Sobue G
- Journal Title
  
  Neurobiol Dis
  
  Volume: 45 Issue: 3 Pages: 862-870
- DOI
  10.1016/j.nbd.2011.12.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229011, KAKENHI-PLANNED-22110005, KAKENHI-PROJECT-22390175, KAKENHI-PUBLICLY-23110526, KAKENHI-PROJECT-23240050, KAKENHI-PROJECT-23659452
[Journal Article] Localization of the proteasomal ubiquitin receptors Rpn10 and Rpn13 by electron cryomicroscopy2012
- Author(s)
  Sakata E, Bohn S, Mihalache O, Kiss P, Beck F, Nagy I, Nickell S, Tanaka K, Saeki Y, Förster F, and Baumeister W.
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 109 Pages: 1479-1484
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Localization of the proteasomal ubiquitin receptors Rpn10 and Rpn13 by electron cryomicroscopy2012
- Author(s)
  Sakata E, Bohn S, Mihalache O, Kiss P, Beck F, Nagy I, Nickell S, Tanaka K, Saeki Y, Forster F, Baumeister W
- Journal Title
  
  Proc Nall Acad Sci USA
  
  Volume: 109 Issue: 1 Pages: 1479-1484
- DOI
  10.1073/pnas.1117648108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Disruption of axonal transport in motor neuron diseases2012
- Author(s)
  Ikenaka K, Katsuno M, Kawai K, Ishigaki S, Tanaka F, Sobue G
- Journal Title
  
  Int J Mol Sci
  
  Volume: 13 Pages: 1225-1238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229011
[Journal Article] Decreased proteasomal activity causes age-related phenotypes and promotes the development of metabolic abnormalities2012
- Author(s)
  Tomaru U, Takahashi S, Ishizu A, Miyatake Y, Gohda A, Suzuki S, Ono A, Ohara J, Baba T, Murata S, Tanaka K, Kasahara M
- Journal Title
  
  Am.J.Pathol.
  
  Volume: 180 Issue: 3 Pages: 963-972
- DOI
  10.1016/j.ajpath.2011.11.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-21390112, KAKENHI-PROJECT-22590353, KAKENHI-PROJECT-23657083, KAKENHI-PROJECT-23659195, KAKENHI-PROJECT-23790430, KAKENHI-PROJECT-23790532, KAKENHI-PROJECT-24390091, KAKENHI-PROJECT-24659171
[Journal Article] Longitudinal changes of outcome measures in spinal and bulbar muscular atrophy.2012
- Author(s)
  Hashizume, A., Katsuno, M., Banno, H., Suzuki, K., Suga, N., Mano, T., Atsuta, N., Oe, H., Watanabe, H., Tanaka, F., Sobue, G.
- Journal Title
  
  Brain
  
  Volume: 35 Issue: 9 Pages: 2838-2848
- DOI
  10.1093/brain/aws170
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229011, KAKENHI-PROJECT-23390230, KAKENHI-PROJECT-23790986
[Journal Article] Pathogenesis and molecular targeted therapy of spinal and bulbar muscular atrophy (SBMA).2012
- Author(s)
  Banno, H., Katsuno, M., Suzuki, K., Tanaka, F., Sobue, G.
- Journal Title
  
  Cell Tissue Res
  
  Volume: 349 Issue: 1 Pages: 313-320
- DOI
  10.1007/s00441-012-1377-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229011, KAKENHI-PROJECT-23790986, KAKENHI-PROJECT-24659428
[Journal Article] Pathogenesis and therapy of spinal and bulbar muscular atrophy (SBMA)2012
- Author(s)
  Katsuno M, Tanaka F, Adachi H, Banno H, Suzuki K, Watanabe H, Sobue G
- Journal Title
  
  Prog Neurobiol
  
  Volume: 99 Issue: 3 Pages: 246-256
- DOI
  10.1016/j.pneurobio.2012.05.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229011, KAKENHI-PROJECT-23390230, KAKENHI-PROJECT-23790986, KAKENHI-PROJECT-24659428
[Journal Article] The proteasome: molecular machinery and pathophysiological roles.2012
- Author(s)
  Tanaka, K., Mizushima, T., and Saeki, Y.
- Journal Title
  
  Biol Chem.
  
  Volume: 393 Pages: 217-234
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria2012
- Author(s)
  尾勝圭
- Journal Title
  
  Nature Communications
  
  Volume: 3 Issue: 1 Pages: 1016-1016
- DOI
  10.1038/ncomms2016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J06061, KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-22370042, KAKENHI-PROJECT-22370071, KAKENHI-PROJECT-23570231, KAKENHI-PROJECT-23570232, KAKENHI-PROJECT-23687018, KAKENHI-PROJECT-24657138, KAKENHI-PROJECT-24790896, KAKENHI-PLANNED-23111003, KAKENHI-PUBLICLY-23129506, KAKENHI-PUBLICLY-24111557, KAKENHI-PUBLICLY-24113717
[Journal Article] β5t-containing thymoproteasome: thymic cortical epithelial cell-specific expression and role in positive selection of CD8+ T cells.2012
- Author(s)
  Takahama, Y., Takada, K., Murata, S., and Tanaka, K.
- Journal Title
  
  Curr. Opini. Immunol.
  
  Volume: 24 Pages: 92-98
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Liver autophagy contributes to the maintenance of blood glucose and amino acid levels.2011
- Author(s)
  Ezaki, J., Matsumoto, N., Takeda-Ezaki, M., Komatsu, M., Takahashi, K., Hiraoka, Y., Taka, H., Fujimura, T., Takehana, K., Yoshida, M., Iwata, J., Tanida, I., Furuya, N., Zheng, D-m., Tada, N., Tanaka, K., Kominami, E., Uenol, T.
- Journal Title
  
  Autophagy
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Crystal structure of the UBA domain of p62 and its interaction with ubiquitin2011
- Author(s)
  Isogai, S., Morimoto, D., Arita, K., Unzai, S., Tenno, T., Hasegawa, J., Sou, Y.S., Komatsu, M., Tanaka, K., Shirakawa, M., Tochio, H.
- Journal Title
  
  J Biol Chem.
  
  Volume: 286 Issue: 36 Pages: 31864-318674
- DOI
  10.1074/jbc.m111.259630
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012, KAKENHI-PLANNED-21121006, KAKENHI-PROJECT-21247013, KAKENHI-PUBLICLY-22113511, KAKENHI-PROJECT-22370038, KAKENHI-PROJECT-22687008, KAKENHI-PLANNED-23115004, KAKENHI-PROJECT-23570145, KAKENHI-PROJECT-23659586
[Journal Article] Autophagy in the intestinal epithelium reduces endotoxin-induced inflammatory responses by inhibiting NF-κB activation.2011
- Author(s)
  Fujishima, Y., Nishiumi, S., Masuda, A., Inoue, J., Nguyen, G.M., Irino, Y., Komatsu, M., Tanaka, K., Kutsumi, H., Azuma, T., Yoshida, M.
- Journal Title
  
  Arch.Biochem.Biophys.
  
  Volume: 506 Pages: 223-235
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] The catalytic activity of Ubp6 enhances maturation of the proteasomal regulatory particle2011
- Author(s)
  Sakata, E., Stengel, F., Fukunaga, K., Zhou, M., Saeki, Y., Forster, F., Baumeister, W., Tanaka, K., and Robinson, CV.
- Journal Title
  
  Mol. Cell
  
  Volume: 42 Pages: 637-649
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Ontogeny of thymic cortical epithelial cells expressing the thymoproteasome subunit beta5t2011
- Author(s)
  Mat Ripen A
- Journal Title
  
  European Journal of Immunology
  
  Volume: 41 Issue: 5 Pages: 1278-1287
- DOI
  10.1002/eji.201041375
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19059010, KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-23249025
[Journal Article] Sharpin is a component of the NF-κB activating linear ubiquitin chain assembly complex2011
- Author(s)
  Tokunaga, F., Nakagawa, T., Nakahara, M., Saeki, Y., Taniguchi, M., Sakata, S., Tanaka, K., Nakano, H., Iwai, I.
- Journal Title
  
  Nature
  
  Volume: 471 Issue: 7340 Pages: 633-636
- DOI
  10.1038/nature09815
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012, KAKENHI-PLANNED-22117006, KAKENHI-PUBLICLY-23117717, KAKENHI-PROJECT-23657075, KAKENHI-PROJECT-23659404
[Journal Article] Parkin mediates apparent E2-independent monoubiquitination in vitro and contains an intrinsic activity that catalyzes polyubiquitination2011
- Author(s)
  Chew, KCM*., Matsuda, M*., Saisho, K., Lim, GGY., Chai, C., Tan, HM., Tanaka, K., Lim, K-L.(*equally contribution)
- Journal Title
  
  PloS ONE.
  
  Volume: 6(5) Issue: 5 Pages: e19720-e19720
- DOI
  10.1371/journal.pone.0019720
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-23687018
[Journal Article] Transforming growth factor-β signaling in motor neuron diseases.2011
- Author(s)
  Katsuno M, Adachi H, Banno H, Suzuki K, Tanaka F, Sobue G.
- Journal Title
  
  Current Mol Med.
  
  Volume: 11 Pages: 48-56
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229011
[Journal Article] Role of persistent activation of Nrf2 through p62 in hepatocarcinogenesis2011
- Author(s)
  Inami, Y., Waguri, S., Sakamoto, A., Kouno, T., Nakada, K., Hino, O., Watanabe, S., Andoh, J., Iwadate, M., Yamatmto, M., Lee. M-S., Tanaka, K., Komatsu, K.
- Journal Title
  
  J.Cell.Biol.
  
  Volume: 193 Pages: 275-284
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Akt suppresses retrograde degeneration of dopaminergic axons by inhibition of macroautophagy2011
- Author(s)
  Chens, H-C., Kim, SR., Oo, TF., Kareva, T., Yarygina, O., Rzhetskaya, M., Wang, C., During, M., Talloczy, Z., Tanaka, K., Komatsu, M., Kobayashi, K., Okano, H., Kholodilov, N., Burke, RE.
- Journal Title
  
  J.Neurosci.
  
  Volume: 31 Issue: 6 Pages: 2125-2135
- DOI
  10.1523/jneurosci.5519-10.2011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Ontogeny of thymic cortical epithelial cells expressing thymoproteasome subunit β5t.2011
- Author(s)
  Ripen, AM., Nitta, T., Murata, S., Tanaka, K., Takahama, Y.
- Journal Title
  
  Eur.J.Immunol.
  
  Volume: 32 Pages: 29-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Role of persistent activation of Nrf2 through p62 in hepatocarcinogenesis.2011
- Author(s)
  Inami, Y., Waguri, S., Sakamoto, A., Kouno, T., Nakada, K., Hino, O., Watanabe, S., Andoh, J., Iwadate, M., Yamamoto, M., Lee.M-S., Tanaka, K., Komatsu, K.
- Journal Title
  
  J.Cell.Biol.
  
  Volume: 193 Pages: 275-284
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Assembly defect due to a PSMB8 mutation reduces proteasome activity and causes the autoinflammatory disorder, Nakajo-Nishimura syndrome2011
- Author(s)
  Arima, K., Kinoshita, A., Mishima, H., Kanazawa, N., Kaneko, T., Mizushima, T., Ichinose, K., Nakamura, H., Tsujino, A., Kawakami, A., Matsunaka, M., Kasagi, S., Kawano, S., Kumagai, S., Ohmura, K., Mimori, T., Hirano, M., Ueno, S., Tanaka, K., Tanaka, M., Toyoshima, I., Sugino, H., Yamakawa, A., Tanaka, K., Niikawa, N., Furukawa, F., Murata, S., Eguchi, K., Ida, H., Yoshiura, K.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA
  
  Volume: 108 Issue: 36 Pages: 14914-14919
- DOI
  10.1073/pnas.1106015108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-21591097, KAKENHI-PROJECT-22591094, KAKENHI-PROJECT-22659071, KAKENHI-PROJECT-23500455, KAKENHI-PROJECT-23591651, KAKENHI-PROJECT-23657083, KAKENHI-PROJECT-23791115, KAKENHI-PROJECT-23791230
[Journal Article] Sharpin is a component of the NF-κB activating linear ubiquitin chain assembly complex.2011
- Author(s)
  Tokunaga, F., Nakagawa, T., Nakaharal, M., Saeki, Y., Taniguchi, M., Sakata, S., Tanaka, K., Nakano, H., Iwai, I.
- Journal Title
  
  Nature
  
  Volume: 471 Pages: 633-636
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Parkin Mediates Apparent E2-independent Monoubiquitination In Vitro and Contains an Intrinsic Activity that Catalyzes Polyubiquitination.2011
- Author(s)
  Chew, KCM., Matsuda, M., Saisho, K., Lim, GGY., Chai, C., Tan, HM., Tanaka, K., Lim 1, K-L.
- Journal Title
  
  PLoS ONE.
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] The catalytic activity of Ubp6 enhances maturation of the proteasomal regulatory particle2011
- Author(s)
  Sakata, E., Stengel, F., Fukunaga, K., et al
- Journal Title
  
  Molecular Cell
  
  Volume: 42 Issue: 5 Pages: 637-649
- DOI
  10.1016/j.molcel.2011.04.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J06251, KAKENHI-PROJECT-20370065, KAKENHI-PROJECT-21000012
[Journal Article] Control of AIF-mediated cell death by antagonistic functions of CHIP ubiquitin E3 ligase and USP2 deubiquitinating enzyme.2011
- Author(s)
  Oh, K.H., Yang, S.W., Park, J.M., Seol, J.H., Iemura, S., Natsume, T., Murata, S., Tanaka, K., Jeon, Y.J., Chung, C.H.
- Journal Title
  
  Cell Death and Differ.
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Autophagy-deficient mice develop multiple liver tumors.2011
- Author(s)
  Takamura, A., Komatsu, M., Hara, T., Sakamoto, A., Kishi, C., Waguri, S., Eishi, Y., Hino O., Tanaka, K., Mizushima, N.
- Journal Title
  
  Genes Dev.
  
  Volume: 25 Pages: 795-800
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] The CD40-Autophagy Pathway Is Needed for Host Protection Despite IFN-Г-Dependent Immunity and CD40 Induces Autophagy via Control of P21 Levels.2011
- Author(s)
  Portillo, J.A., Okenka, G., Reed, E., Subauste, A., Van, Grol, J., Gentil, K., Komatsu, M., Tanaka, K., Landreth, G., Levine, B., Subauste, C.S.
- Journal Title
  
  PLoS One.
  
  Volume: 5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Control of AIF-mediated cell death by antagonistic functions of CHIP ubiquitin E3 ligase and USP2 deubiquitinating enzyme2011
- Author(s)
  Oh, K.H., Yang, S.W., Park, J.M., Seol, J.H., Iemura, S., Natsume, T., Murata, S., Tanaka, K., Jeon, Y.J., Chung, C.H.
- Journal Title
  
  Cell Death Differ.
  
  Volume: 18 Issue: 8 Pages: 1326-1336
- DOI
  10.1038/cdd.2011.3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Liver autophagy contributes to the maintenance of blood glucose and amino acid levels2011
- Author(s)
  Ezaki, J., Matsumoto, N., Takeda-Ezaki, M., Komatsu, M., Takahashi, K., Hiraoka, Y., Taka, H., Fujimura, T., Takehana, K., Yoshida, M., Iwata, J., Tanida, I., Furuya, N., Zheng, D-m., Tada, N., Tanaka, K., Kominami, E., Ueno, T.
- Journal Title
  
  Autophagy
  
  Volume: 7 Issue: 7 Pages: 727-736
- DOI
  10.4161/auto.7.7.15371
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-21570155, KAKENHI-PROJECT-22700656
[Journal Article] Autophagy-deficient mice develop multiple liver tumors2011
- Author(s)
  Takamura, A., Komatsu, M., Hara, T., Sakamoto, A., Kishi, C., Waguri, S., Eishi, Y., Hino O., Tanaka, K., Mizushima, N
- Journal Title
  
  Genes Dev.
  
  Volume: 25 Issue: 8 Pages: 795-800
- DOI
  10.1101/gad.2016211
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-21659045
[Journal Article] Structure of ubiquitin-fold modifier 1 specific protease, UfSP22011
- Author(s)
  Ha, B.H., Jeon, Y.J., Shin, S.C., Tatsumi, K., Komatsu, M., Tanaka, K., Watson, C.M., Wallis, G., Chung, C.H., Kim, E.E.
- Journal Title
  
  J.Biol.Chem.
  
  Volume: 286 Issue: 12 Pages: 10248-10257
- DOI
  10.1074/jbc.m110.172171
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Skp1 stabilizes the conformation of F-box proteins2011
- Author(s)
  Yoshida, Y., Murakami, A., Tanaka, K.
- Journal Title
  
  Biochem.Biophys.Res.Commun.
  
  Volume: 41 Issue: 1 Pages: 24-28
- DOI
  10.1016/j.bbrc.2011.05.098
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-21580121
[Journal Article] A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans2011
- Author(s)
  Kitamura A, Maekawa Y, Uehara H, Izumi K, Kawachi I, Nishizawa M, Toyoshima Y, Takahashi H, Standley DM, Tanaka K, Hamazaki J, Murata S, Obara K, Toyoshima I, Yasutomo K.
- Journal Title
  
  J Clin Invest
  
  Volume: 121 Issue: 10 Pages: 4150-4160
- DOI
  10.1172/jci58414
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20679005, KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-21570169, KAKENHI-PROJECT-21590536, KAKENHI-PROJECT-23591236, KAKENHI-PROJECT-23657083, KAKENHI-PROJECT-23791179
[Journal Article] Akt Suppresses Retrograde Degeneration of Dopaminergic Axons by Inhibition of Macroautophagy.2011
- Author(s)
  Cheng, H-C., Kim, SR., Oo, TF., Kareva, T., Yarygina, O., Rzhetskaya, M., Wang, C., During, M., Talloczy, Z., Tanaka, K., Komatsu, M., Kobayashi, K., Okano, H., Kholodilov, N., Burke, RE.
- Journal Title
  
  J.Neurosci.
  
  Volume: 31 Pages: 2125-2135
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Structure of ubiquitin-fold modifier 1 specific protease, UfSP2.2011
- Author(s)
  Ha, B.H., Jeon, Y.J., Shin, S.C, Tatsumi, K., Komatsu, M., Tanaka, K., Watson, C.M., Wallis, G., Chung, C.H., Kim, E.E.
- Journal Title
  
  J.Biol.Chem.
  
  Volume: 286 Pages: 10248-10257
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] The catalytic activity of Ubp6 enhances maturation of the proteasomal regulatory particle.2011
- Author(s)
  Sakata, E., Stengel, F., Fukunaga, K., Zhou, M., Saeki, Y., Forster, F., Baumeister, W., Tanaka, K., Robinson, CV.
- Journal Title
  
  Mol.Cell
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Autophagy in the intestinal epithelium reduces endotoxin-induced inflammatory responses by inhibiting NF-κB activation2011
- Author(s)
  Fujishima, Y., Nishiumi, S., Masuda, A., Inoue, J., Nguyen, G.M., Irino, Y., Komatsu, M., Tanaka, K., Kutsumi, H., Azuma, T., Yoshida, M.
- Journal Title
  
  Arch.Biochem.Biophys.
  
  Volume: 506 Pages: 223-235
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy.2010
- Author(s)
  Matsuda N, Sato S, Shiba K, Okatsu K, Saisho K, Gautier CA, Sou YS, Saiki S, Kawajiri S, Sato F, Kimura M, Komatsu M, Hattori N, Tanaka K.
- Journal Title
  
  J Cell Biol 189
  
  Pages: 211-221
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790853
[Journal Article] Thymoproteasome shapes immunocompetent repertoire of CD8 T cells.2010
- Author(s)
  Nitta, T., Murata, S., Sasaki, K., Fujii, H., Ripen, A.M., Ishimaru, N., Koyasu, S., Tanaka, K., Takahama, Y.
- Journal Title
  
  Immunity
  
  Volume: 32 Pages: 29-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Crystallization and preliminary X-ray characterization of Skp1-FBG3 complex.2010
- Author(s)
  Kumanomidou, T., Nakagawa, T., Mizushima, T., Suzuki, A., Tokunaga, F., Iwai, K., Yoshida, Y., Tanaka, K., Yamane, T.
- Journal Title
  
  Acta Crystallogr Sect F Struct Biol Cryst Commun.
  
  Volume: 66 Pages: 95-98
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Activity-based profiling reveals reactivity of the murine thymoproteasome-specific subunit beta5t.2010
- Author(s)
  Florea, B.I., Verdoes, M., Li, N., van den Linden, W.A., Geurink, P.P., van den Elst, H., Hofmann, T., de Ru, A., van Veelen, P.A., Tanaka, K., Sasaki, K., Murata, S., den Dulk, H., Brouwer, J., Ossendorp, F.A., Kisselev, A.F., Overkleeft, H.S.
- Journal Title
  
  Chem Biol.
  
  Volume: 17 Pages: 795-801
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.2010
- Author(s)
  Komatsu, M., Kurokawa, H., Waguri, S., Taguchi, K., Kobayashi, A., Ichimura, Y., Sou, Y-S., Ueno, I., Sakamoto, A., Tong.K.I., Kim, M., Nishito Y., Iemura, S., Natsume, T., Ueno, T., Kominami, E., Motohashi, H., Tanaka, K., Yamamoto, M.
- Journal Title
  
  Nat.Cell Biol.
  
  Volume: 12 Pages: 213-223
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Regulatory mechanisms involved in the control of ubiquitin homeostasis.2010
- Author(s)
  Kimura, Y., Tanaka, K.
- Journal Title
  
  J.Biochem.
  
  Volume: 147 Pages: 793-798
- NAID
  10027876238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Novel type of E3 ligase for Ufm1-conjugating system.2010
- Author(s)
  Tatsumi, K., Sou, Y., Tada, N., Nakamura, E., Iemura, S., Natsume, T., Kang, SW., Chung, CH., Kasahara, M., Kominami, E., Tanaka, K., Komatsu, M.
- Journal Title
  
  J.Biol.Chem.
  
  Volume: 285 Pages: 5417-5427
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Dorfin ameliorates phenotypes in a transgenic mouse model of amyotrophic lateral sclerosis2010
- Author(s)
  Sone J, Niwa JI, Kawai K, Ishigaki S, Yamada SI, Adachi H, Katsuno M, Tanaka F, Doyu M, Sobue G.
- Journal Title
  
  J Neurosci Res. 88
  
  Pages: 123-135
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229011
[Journal Article] Disrupted TGF-beta signaling in spinal and bulbar muscular atrophy2010
- Author(s)
  Katsuno M, Adachi H, Minamiyama M, Waza M, Doi H, Kondo N, Mizoguchi H, Nitta A, Yamada K, Banno H, Suzuki K, Tanaka F, Sobue G.
- Journal Title
  
  J Neurosci. 30
  
  Pages: 5702-5712
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229011
[Journal Article] Clinical features and molecular mechanisms of spinal and bulbar muscular atrophy (SBMA).2010
- Author(s)
  Katsuno M, Banno H, Suzuki K, Adachi H, Tanaka F, Sobue G.
- Journal Title
  
  Adv Exp Med Biol.
  
  Volume: 685 Pages: 64-74
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229011
[Journal Article] Ubiquitin accumulation in autophagy-deficinet mice is dependent on the Nrf2-mediated stress response pathway : a potential role for protein aggregation in autophagic substrate selection.2010
- Author(s)
  Riley, B.E., Kaiser, S.E., Shaler, T.A., Ng, A.C.Y., Hara, T., Hipp, M.S., Lage, K., Xavier, R.J., Ryu, K-Y., Taguchi, K., Yamamoto, M., Tanaka, K., Mizushima, N., Komatsu, M., Kopito, R.R.
- Journal Title
  
  J.Cell Biol.
  
  Volume: 191 Pages: 537-552
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] PINK1 stabilized by depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy.2010
- Author(s)
  Matsuda, N., Sato, S., Shiba, K., Okatsu, K., Saisho, K., Gautier, CA Sou, Y., Saiki, S., Kawajiri, S., Sato, F., Kimura, M., Komatsu, M., Hattori, N., Tanaka, K.
- Journal Title
  
  J Cell Biol.
  
  Volume: 189 Pages: 211-221
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense.2010
- Author(s)
  Arimoto, K.I., Funami, K., Saeki, Y., Tanaka, K., Okawa, K., Takeuchi, O., Akira, S., Murakami, Y., Shimotohno, K.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA
  
  Volume: 07 Pages: 15856-15861
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria.2010
- Author(s)
  Okatsu, K., Saisho, K., Shimanuki, M., Nakada, K., Shitara, H., Sou, Y., Kimura, M., Sato, S., Hattori, N., Komatsu, M., Tanaka.K., Matsuda, N.
- Journal Title
  
  Genes Cells
  
  Volume: 15 Pages: 887-900
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and importance of latent 20S proteasomes in maintaining cellular homeostasis.2010
- Author(s)
  Sasaki, K., Hamazaki, J., Koike, M., Hirano, Y., Komatsu, M., Uchiyama, Y., Tanaka, K., Murata, M.
- Journal Title
  
  Mol Cell.Biol.
  
  Volume: 30 Pages: 3864-3874
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Disrupted transforming growth factor-beta signaling in spinal and bulbar muscular atrophy.2010
- Author(s)
  Katsuno M, Adachi H, Minamiyama M, Waza M, Doi H, Kondo N, Mizoguchi H, Nitta A, Yamada K, Banno H, Suzuki K, Tanaka F, Sobue G
- Journal Title
  
  J Neurosci
  
  Volume: 30 Pages: 5702-5712
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229011
[Journal Article] The profile of motor unit number estimation (MUNE) in spinal and bulbar muscular atrophy2010
- Author(s)
  Suzuki K, Katsuno M, Banno H, Takeuchi Y, Kawashima M, Suga N, Hashizume A, Hama T, Uchida K, Yamashita F, Nakamura T, Hirayama M, Tanaka F, Sobue G.
- Journal Title
  
  J Neurol Neurosurg Psychiatry 81
  
  Pages: 567-571
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229011
[Journal Article] Lectin-like ERAD players in ER and cytosol.2010
- Author(s)
  Yoshida, Y., Tanaka, K.
- Journal Title
  
  Biochem.Biophys.Acta
  
  Volume: 1800 Pages: 172-180
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] PINK1 stabilized by depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy2010
- Author(s)
  Matsuda, N., Sato, S., Shiba, K., Okatsu, K., Saisho, K., Gautier, CA Sou, Y., Saiki, S., Kawajiri, S., Sato, F., Kimura, M., Komatsu, M., Hattori, N., and Tanaka, K.
- Journal Title
  
  J Cell Biol.
  
  Volume: 189 Pages: 211-221
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response.2010
- Author(s)
  Maruyama, T., Kadowaki, H., Okamoto, N., Nagai, A., Naguro, I., Matsuzawa, A., Shibuya, H., Tanaka, K., Murata, S., Takeda, K., Nishito, h H., Ichijo, H.
- Journal Title
  
  EMBO J.
  
  Volume: 9 Pages: 2501-2514
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Does impairment of the ubiquitin-proteasome system or the autophagy-lysosome pathway predispose individuals to neurodegenerative disorders such as Parkinson's disease?2010
- Author(s)
  Matsuda, N., Tanaka, K.
- Journal Title
  
  J Alzheimer's Dis.
  
  Volume: 19 Pages: 1-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Dissection of the assembly pathway of the proteasome lid in Saccharomyces cerevisiae.2010
- Author(s)
  Fukunaga, K., Kudo, T., Toh-e, A., Tanaka, K., Saeki, Y.
- Journal Title
  
  Biochem.Biophys.Res.Commun.
  
  Volume: 396 Pages: 1048-1053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Role of thymic cortex-specific self-peptides in positive selection of T cells.2010
- Author(s)
  Takahama, Y., Nitta, T., Ripen, A.M., Nitta, S., Murata, M., Tanaka, K.
- Journal Title
  
  Semin.Immunol.
  
  Volume: 22 Pages: 287-293
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Disrupted TGF-beta signaling in spinal and bulbar muscular atrophy2010
- Author(s)
  Katsuno M, Adachi H, Minamiyama M, Waza M, Doi H, Kondo N, Mizoguchi H, Nitta A, Yamada K, Banno H, Suzuki K, Tanaka F, Sobue G
- Journal Title
  
  J Neurosci
  
  Volume: 30 Issue: 16 Pages: 5702-5712
- DOI
  10.1523/jneurosci.0388-10.2010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229011
[Journal Article] Crystal structure of UbcH5b～ubiquitin intermediate : Insight into the formation of the self-assembled E2～Ub conjugates.2010
- Author(s)
  Sakata, E., Satoh, T., Yamamoto, S., Yamaguchi, Y., Yagi-Utsumi, M., Kurimoto, E., Tanaka, K., Wakatsuki, S., Kato, K.
- Journal Title
  
  Structure
  
  Volume: 18 Pages: 138-147
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Crystal structure of yeast Rpn14, a chaperone of the 19S regulatory particles of the proteasome.2010
- Author(s)
  Kim, S., Saeki, S., Fukunaga, K., Suzuki, A., Takagi, K., Yamane, T., Tanaka, K., Mizushima, T., Kato, K.
- Journal Title
  
  J.Biol.Chem.
  
  Volume: 285 Pages: 15159-151566
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Efficacy and safety of leuprorelin in patients with spinal and bulbar muscular atrophy (JASMITT study) : a multicentre, randomised, double-blind, placebo-controlled trial.2010
- Author(s)
  Katsuno M, Banno H, Suzuki K, Takeuchi Y, Kawashima M, Yabe I, Sasaki H, Aoki M, Morita M, Nakano I, Kanai K, Ito S, Ishikawa K, Mizusawa H, Yamamoto T, Tsuji S, Hasegawa K, Shimohata T, Nishizawa M, Miyajima H, Kanda F, Watanabe Y, Nakashima K, Tsujino A, Yamashita T, Uchino M, Fujimoto Y, Tanaka F, Sobue Cr ; for the Japan SBMA Interventional Trial for TAP-144-SR (JASMITT) study group.
- Journal Title
  
  Lancet Neurol.
  
  Volume: 9 Pages: 875-884
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229011
[Journal Article] PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy.2010
- Author(s)
  Matsuda N, Sato S, Shiba K, Okatsu K, Saisho K, Gautier CA, Sou YS, Saiki S, Kawajiri S, Sato F, Kimura M, Komatsu M, Hattori N, Tanaka K.
- Journal Title
  
  Journal of Cell Biology
  
  Volume: 189 Pages: 211-221
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790853
[Journal Article] Thymoproteasome shapes immunocompetent repertoire of CD8 T cells2010
- Author(s)
  Nitta, T., Murata, S., Sasaki, K., Fujii, H., Ripen, A. M., Ishimaru, N., Koyasu, S., Tanaka, K., and Takahama, Y.
- Journal Title
  
  Immunity
  
  Volume: 32 Pages: 29-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] The proteasome : Overview of structure and functions.2009
- Author(s)
  Tanaka, K.
- Journal Title
  
  Proc. Jpn. Acad. Ser B Phys Biol Sci. 85
  
  Pages: 12-36
- NAID
  130000093918
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] Assembly pathway of the mammalian proteasome base subcomplex is mediated by multiple specific chaperones2009
- Author(s)
  Kaneko, T., Hamazaki, J., Iemura, S., Sasaki, K., Furuyama, K., Natsume, T., Tanaka, K., and Murata, S.
- Journal Title
  
  Cell
  
  Volume: 137 Pages: 914-925
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Autophagy regulates lipid metabolism.2009
- Author(s)
  Singh, R., Kaushik, S., Wang, Y., Xiang, Y., Novak, I., Komatsu, M., Tanaka, K., Cuervo, AM, and Czaja, M.
- Journal Title
  
  Nature 458
  
  Pages: 1131-1135
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] Thymic environments of T-cell repertoire formation.2009
- Author(s)
  Nitta, T., Murata, S., Ueno, T., Tanaka, K., and Takahama, Y.
- Journal Title
  
  Adv Immunol in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] Molecular mechanisms of proteasome assembly.2009
- Author(s)
  Murata, S., Yashiroda, H., and Tanaka, K.
- Journal Title
  
  Nat Rev Mol Cell Biol 10
  
  Pages: 104-115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] Correlation between pyramidal tract degeneration and widespread white matter involvement in amyotrophic lateral sclerosis : a study with tractography and diffusion-tensor imaging2009
- Author(s)
  Senda J, Ito M, Watanabe H, Atsuta N, Kawai Y, Katsuno M, Tanaka F, Naganawa S, Fukatsu H, Sobue G.
- Journal Title
  
  Amyotroph Lateral Scler. 10
  
  Pages: 288-294
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229011
[Journal Article] Genetic evidence linking age-dependent attenuation of the 26S proteasome with aging process.2009
- Author(s)
  Tonoki, A., Kuranaga, E., Tomioka, T., Hamazaki, J., Murata, S., Tanaka, K., and Miura. M.
- Journal Title
  
  Mol Cell Biol. 29
  
  Pages: 1095-1106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] An inhibitor of deubiquitinating enzyme regulates ubiquitin homeostasis2009
- Author(s)
  Kimura, Y., Yashiroda, H., Kudo, T., Koitabashi, S., Murata, S., Kakizuka, A., and Tanaka, K.
- Journal Title
  
  Cell
  
  Volume: 137 Pages: 549-559
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] Linear ubiquitination of NEMO triggers NF-κB activation.2009
- Author(s)
  Tokunaga, T., Sakata, S., Satomi, Y., Kirisako, T., Kamei, K., Nakagawa, T., Murata, S., Yamaoka, S., Takao, T., Tanaka, K., and Iwai K.
- Journal Title
  
  Nature Cell Biol. 11
  
  Pages: 123-132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] The proteasome: Overview of structure and functions.2009
- Author(s)
  Tanaka, K.
- Journal Title
  
  Proc Jpn Acad Ser B85
  
  Pages: 12-36
- NAID
  130000093918
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] Multiple proteasome-interacting proteins assist the assembly of the yeast 19S regulatory particle2009
- Author(s)
  Saeki, Y., Toh-e, A., Kudo, T., Kawamura, H., and Tanaka, K.
- Journal Title
  
  Cell
  
  Volume: 137 Pages: 900-913
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012
[Journal Article] An inhibitor of deubiquitinating enzyme regulates ubiquitin homeostasis.2009
- Author(s)
  Kimura, Y., Yashiroda, H., Kudo, T., Koitabashi, S., Murata, S., Kakizuka, A., and Tanaka, K.
- Journal Title
  
  Cell in press (May 1^<st>).
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] Lysine 63-linked polyubiquitin chain may serve as a targeting signal for the 26S proteasome.2009
- Author(s)
  Saeki, Y., Kudo, T., Sone, T., Kikuchi, Y., Yokosawa, H., Toh-e, A., Tanaka, K.
- Journal Title
  
  EMBO J 28
  
  Pages: 359-371
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] Molecular mechanisms of proteasome assembly.2009
- Author(s)
  Murata, S., Yashiroda, H., Tanaka, K.
- Journal Title
  
  Nat Rev Mol Cell Biol 10
  
  Pages: 104-115
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] The cellular pathways of neuronal autophagy and their implication in neurodegenerative diseases.2009
- Author(s)
  Yue, Z., Friedman, L., Komatsu, M., and Tanaka, K.
- Journal Title
  
  Biochem Biophys Acta - Mol Cell Res. in press.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] TDP-43 Depletion Induces Neuronal Cell Damage through Dysregulation of Rho Family GTPases2009
- Author(s)
  Iguchi Y, Katsuno M, Niwa J, Yamada S, Sone J, Waza M, Adachi H, Tanaka F, Nagata K, Arimura N, Watanabe T, Kaibuchi K, Sobue G.
- Journal Title
  
  J Biol Chem. 284
  
  Pages: 22059-22066
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229011
[Journal Article] An inhibitor of deubiquitinating enzyme regulates ubiquitin homeostasis.2009
- Author(s)
  Kimura, Y., Yashiroda, H., Kudo, T., Koitabashi, S., Murata, S., Kakizuka, A., Tanaka, K.
- Journal Title
  
  Cell 137
  
  Pages: 549-559
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] Assembly pathway of the mammalian proteasome base subcomplex is mediated by multiple specific chaperones.2009
- Author(s)
  Kaneko, T., Hamazaki, J., Iemura, S., Sasaki, K., Furuyama, K., Natsume, T., Tanaka, K., Murata, S.
- Journal Title
  
  Cell 137
  
  Pages: 914-925
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] Exclusive expression of proteasome subunit β5t in the human thymic cortex.2009
- Author(s)
  Tomaru, U., Ishizu, A., Murata, S., Miyakate, Y., Suzuki, S., Takahashi, S., Kazamaki, T., Ohara, J., Baba, T., Iwasaki, S., Fugo, K., Otsuka, N., Tanaka, K., and Kasahara, M.
- Journal Title
  
  Blood in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] Heat shock proteins in neurodegenerative diseases : Pathogenic roles and therapeutic implications2009
- Author(s)
  Adachi H, Katsuno M, Waza M, Minamiyama M, Tanaka F, Sobue G.
- Journal Title
  
  Int J Hyperthermia 25
  
  Pages: 647-654
- Data Source
  KAKENHI-PROJECT-21229011
[Journal Article] Multiple proteasome-interacting proteins assist the assembly of the yeast 19S regulatory particle.2009
- Author(s)
  Saeki, Y., Toh-e, A., Kudo, T., Kawamura, H., Tanaka, K.
- Journal Title
  
  Cell 137
  
  Pages: 900-913
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] Lysine 63-linked polyubiquitin chain may serve as a targeting signal for the 26S proteasome.2009
- Author(s)
  Saeki, Y., Kudo, T., Sone, T., Kikuchi, Y., Yokosawa, H., Toh-e, A., and Tanaka, K.
- Journal Title
  
  EMBO J. 28
  
  Pages: 359-371
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] Mammalian 26S proteasomes remain intact during protein degradation.2008
- Author(s)
  Kriegenburg, F., Seeger, M., Saeki, Y., Tanaka, K., Lauridsen, A-M.B., Hartmann-Petersen, R., Hendil, K.B.
- Journal Title
  
  Cell 135
  
  Pages: 355-365
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] Cell biology : two hands for degradation.2008
- Author(s)
  Saeki, Y. and Tanaka, K.
- Journal Title
  
  Nature (News and Views) 453
  
  Pages: 460-461
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice.2008
- Author(s)
  Sou, Y., Waguri, S., Iwata, J., Ueno, T., Fujimura, T., Hara, T., Sawada, N., Yamada, A., Mizushima, N., Uchiyama, Y., Kominami, E., Tanaka, K., and Komatsu, M.
- Journal Title
  
  Mol Biol Cell 19
  
  Pages: 4762-4775
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] Thymoproteasome: probable role in generating positively selecting peptides.2008
- Author(s)
  Murata, S., Takahama, Y., Tanaka, K.
- Journal Title
  
  Curr Opini Immunol 20
  
  Pages: 192-196
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] Cell biology: two hands for degradation.2008
- Author(s)
  Saeki, Y., Tanaka, K.
- Journal Title
  
  Nature 453
  
  Pages: 460-461
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] Mammalian 26S proteaspmes remain intact during protein degradation.2008
- Author(s)
  Kriegenburg, F., Seeger, M., Saeki, Y., Tanaka, K., Lauridsen, A-M. B., Hartmann-Petersen, R., and Hendil, K. B.
- Journal Title
  
  Cell 135
  
  Pages: 355-365
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] Crystal structure of a chaperone complex that contributes to the assembly of yeast 20S proteasomes.2008
- Author(s)
  Yashiroda, H., Mizushima, T., Okamoto, K., Kameyama, T., Hayashi, H., Kishimoto, T., Kasahara, M., Kurimoto, E., Sakata, E., Suzuki, A., Hirano, Y., Murata, S., Kato, K., Yamane, T., Tanaka, K.
- Journal Title
  
  Nat Struct Mol Biol 15
  
  Pages: 228-236
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] Selective turnover of p62/a170/Sqstm1 by autophagy.2008
- Author(s)
  Ichimura, Y., Kominami, E., Tanaka, K., and Komatsu, M.
- Journal Title
  
  Autophagy 4
  
  Pages: 1063-1066
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] Autophagy in pancreatic beta cells is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet.2008
- Author(s)
  Ebato, C., Uchida, T., Arakawa, M., Komatsu, M., Ueno, T., Azumal, K., Hirose, T., Tanaka, K., Kominami, E., Kawamori, R., Fujitani, Y., and Watada, H.
- Journal Title
  
  Cell Metab. 8
  
  Pages: 325-332
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] Modest cortex and promiscuous medulla for thymic repertoire formation.2008
- Author(s)
  Takahama, Y., Tanaka, K., and Murata, S.,
- Journal Title
  
  Trends Immunol 29
  
  Pages: 251-155
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] c-Cbl-dependent monoubiquitination and lysosomal degradation of gp1302008
- Author(s)
  Tanaka, Y., et. al.
- Journal Title
  
  Mol.Cell.Biol 28
  
  Pages: 4805-4818
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] Dissecting β-ring assembly pathway of the mammalian 20S proteasome.2008
- Author(s)
  Hirano, Y., Kaneko, T., Okamoto, K., Bai, M., Yashiroda, H., Furuyama, K., Kato, K., Tanaka, K., and Murata, S.
- Journal Title
  
  EMBO J. 27
  
  Pages: 2204-2213
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] -ring assembly pathway of the mammalian 20S proteasome.2008
- Author(s)
  Hirano, Y., Kaneko, T., Okamoto, K., Bai, M., Yashiroda, H., Furuyama, K., Kato, K., Tanaka, K., Murata, S.
- Journal Title
  
  EMBO J 27
  
  Pages: 2204-2213
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] A novel ubiquitin ligase involved in p57^<Kip2> proteolysis regulates osteoblast cell differentiation.2008
- Author(s)
  Kim, M., Nakamoto, T., Nishimori, S., Tanaka, K., and Chiba, T.
- Journal Title
  
  EMBO Rep. 9
  
  Pages: 878-884
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] Crystal structure of a chaperone complex that contributes to the assembly of yeast 20S proteasomes.2008
- Author(s)
  Yashiroda, H., Mizushima, T., Okamoto, K., Kameyama, T., Hayashi, H., Kishimoto, T., Kasahara, M., Kurimoto, E., Sakata, E., Suzuki, A., Hirano. Y., Murata, S., Kato, K., Yamane, T., and Tanaka, K.
- Journal Title
  
  Nature Struct. Mol. Biol. 15
  
  Pages: 228-236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] Thymoproteasome : probable role in generating positively selecting peptides.2008
- Author(s)
  Murata, S., Takahama, Y., and Tanaka, K.
- Journal Title
  
  Curr Opini Immunol 20
  
  Pages: 192-196
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] Essential role of Macroautophagy in Pancreatic β-Cell Survival and Proliferation.2008
- Author(s)
  Jung, HS., Chung, KW., Kim, JW., Kim, J., Komatsu, M., Tanaka, K., Nguyen, YH., Kang, TM., Jeong, YT., Han, MS., Lee, MK., Kim, KW., and Lee, MS.
- Journal Title
  
  Cell Metab. 8
  
  Pages: 318-324
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] Unlocking the proteasome door.2007
- Author(s)
  Saeki, Y, Tanaka, K.
- Journal Title
  
  Mol Cell 27
  
  Pages: 865-867
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] Regulation of CD8+ T cell development by thymus-specific proteasomes.2007
- Author(s)
  Murata, S., Sasaki, K., Kishimoto, T., Niwa, S., Hayashi, H., Takahama, Y., Tanaka, K.
- Journal Title
  
  Science 316
  
  Pages: 1349-1353
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] Structural basis for selection of glycosylated substrate by SCFFbs1 ubiquitin ligase.2007
- Author(s)
  Mizushima, T., Yoshida, Y., Kumanomidou, T., Hasegawa, Y., Suzuki, A., Yamane, T., Tanaka, K.
- Journal Title
  
  Proc Natl Acad Sci USA 104
  
  Pages: 5777-5781
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice.2007
- Author(s)
  Komatsu, M., Waguri, S., Koike, M., Sou, Y., Ueno, T., Hara, T., Mizushima, N., Iwata, J., Ezaki, J., Murata, S., Hamazaki, J., Nishito, Y., Iemura, S., Natsume, N., Yanagawa, T., Uwayama, J., Warabi, E., Yoshida, H., Ishii, T., Kobayashi, A., Yamamoto, M., Yue, Z., Uchiyama, Y., Kominami, E., Tanaka, K.
- Journal Title
  
  Cell 131
  
  Pages: 1149-1163
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes.2006
- Author(s)
  Hamazaki, J., Iemura, S., Natsume, T., Yashiroda, H., Tanaka, K., Murata, S.
- Journal Title
  
  EMBO J. 25
  
  Pages: 4524-4536
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] Cooperation of multiple chaperones required for the assembly of mammalian 20S proteasomes.2006
- Author(s)
  Hirano, Y., Hayashi, H., Iemura, S., Hendil, K.B., Niwa, S., Kishimoto, T., Natsume, T., Kasahara, M., Tanaka, K., Murata, S.
- Journal Title
  
  Mol Cell 24
  
  Pages: 977-984
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] Loss of autophagy in the central nervous system causes neurodegeneration2006
- Author(s)
  Komatsu, M., Waguri, S., Chiba, T., Murata, S., Iwata, J., Ueno, T., Koike, M., Uchiyama, Y., Kominami, E., Tanaka, K.
- Journal Title
  
  Nature 441
  
  Pages: 880-884
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] Loss of autophagy in the central nervous system causes neurodegeneration.2006
- Author(s)
  Komatsu, M., Waguri, S., Chiba, T., Murata, S., Iwata, J., Ueno, T., Koike, M., Uchiyama, Y., Kominami, E., Tanaka, K.
- Journal Title
  
  Nature 441
  
  Pages: 880-884
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] 14-3-3h is a novel regulator of parkin ubiquitin-ligase2006
- Author(s)
  Sato, S., Chiba, T., Sakata, E., Kato, K., Mizuno, Y., Hattori, N, Tanaka, K
- Journal Title
  
  EMBO J. 25
  
  Pages: 211-221
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13002008
[Journal Article] Diverse effects of pathogenic mutations of Parkin that catalyzes multiple mono-ubiquitylation in vitro2006
- Author(s)
  Matsuda, N., Kitami, T., Suzuki, T., Mizuno, Y., Hattori, N., Tanaka, K.
- Journal Title
  
  J. Biol. Chem. 281
  
  Pages: 3204-3209
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13002008
[Journal Article] Diverse effects of pathogenic mutations of Parkin that catalyzes multiple mono-ubiquitylation in vitro2006
- Author(s)
  Matsuda, N., Kitami, T., Suzuki, T., Mizuno, Y., Hattori, N., Tanaka, K
- Journal Title
  
  J. Biol. Chem. 281
  
  Pages: 3204-3209
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] 14-3-3h is a novel regulator of parkin ubiquitin-ligase2006
- Author(s)
  Sato, S., Chiba, T., Sakata, E., Kato, K., Mizuno, Y., Hattori, N, Tanaka, K.
- Journal Title
  
  EMBO J. 25
  
  Pages: 211-221
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13002008
[Journal Article] SUMO-specific protease UlpA positively regulates p53 tumor suppressor by promoting self-ubiquitination of Mdm22006
- Author(s)
  Moon Hee Lee, M.H., Lee, E.J., Choi, S., J., Lee, S.W., Chung, S.S., Seol, J.H., Baek, S.H., Kim, K.L., Chiba, T., Tanaka, K., Bang, O.S., Chung, C.H.
- Journal Title
  
  Nature Cell Biol. 8
  
  Pages: 1424-1431
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] 14-3-3h is a novel regulator of parkin ubiquitin-ligase2006
- Author(s)
  Sato, S., Chiba, T., Sakata, E., Kato, K., Mizuno, Y., Hattori, N., Tanaka, K.
- Journal Title
  
  EMBO J. 25
  
  Pages: 211-221
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes2006
- Author(s)
  Hamazaki, J., Iemura, S., Natsume, T., Yashiroda, H., Tanaka, K., Murata, S.
- Journal Title
  
  EMBO J. 25
  
  Pages: 4524-4536
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] Cooperation of multiple chaperones required for the assembly of mammalian 20S proteasomes2006
- Author(s)
  Hirano, Hayashi, H., Iemura, S., Hendil, K.B., Niwa, S., Kishimoto, T., Natsume, T., Kasahara, M., Tanaka, K., Murata, S.
- Journal Title
  
  Mol Cell 24
  
  Pages: 977-984
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] DDB2, the xeroderma pigmentosum group E gene product, is directly ubiquitylated by Cullin 4A-based ubiquitin ligase complex2005
- Author(s)
  Matsuda, N., Azuma, K., Saijo, M., Iemura, S-I., Hioki, Y., Natsume, T., Chiba, T., Tanaka, K., Tanaka, K.
- Journal Title
  
  DNA Repair 4
  
  Pages: 537-545
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13002008
[Journal Article] A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes2005
- Author(s)
  Hirano, Y., Hendil, K.B., Yashiroda, H., Iemura, S., Nagane, R., Hioki, Y., Natsume, T., Tanaka, K., Murata, S.
- Journal Title
  
  Nature 437
  
  Pages: 1381-1385
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice.2005
- Author(s)
  Komatsu, M., Waguri, S., Ueno, T., Murata, S., Tanida, I., Ezaki, E., Mizushima, N., Ohsumi, Y., Uchiyama, Y., Kominami, E., Tanaka, K., Chiba, T.
- Journal Title
  
  J. Cell Biol 169
  
  Pages: 425-434
- Data Source
  KAKENHI-PROJECT-17002019
[Journal Article] Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice2005
- Author(s)
  Komatsu, M., Waguri, S., Ueno, T., Murata, S., Tanida, I., Ezaki, E., Mizushima, N., Ohsumi, Y., Uchiyama, Y., Kominami, E., Tanaka, K., Chiba, T.
- Journal Title
  
  J. Cell Biol. 169
  
  Pages: 425-434
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13002008
[Journal Article] A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes2005
- Author(s)
  Hirano, Y., Hendil, K.B., Yashiroda, H., Iemura, S., Nagane, R., Hioki, Y., Natsume, T., Tanaka, K., Murata, S.
- Journal Title
  
  Nature 437
  
  Pages: 1381-1385
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13002008
[Journal Article] UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex.2005
- Author(s)
  Sugasawa, K., Okuda, Y., Saijo, M., Nishi, R., Matsuda, N., Chu, G., Mori, T., Iwai, S., Tanaka, K., Hanaoka, F.
- Journal Title
  
  Cell (in press)
- Data Source
  KAKENHI-PROJECT-13002008
[Journal Article] Glycoprotein-specific ubiquitin-ligases recognize N-glycans in unfolded substrates2005
- Author(s)
  Yoshida, Y., Fukiya, K., Adachi, E., Iwai, K., Tanaka, K.
- Journal Title
  
  EMBO Rep. 6
  
  Pages: 239-244
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13002008
[Journal Article] Glycoprotein-specific ubiquitin-ligases recognize N-glycans in unfolded.2005
- Author(s)
  Yoshida, Y., Fukiya, K., Adachi, E., Iwai, K., Tanaka, K.
- Journal Title
  
  EMBO Rep. 6
  
  Pages: 239-244
- Data Source
  KAKENHI-PROJECT-13002008
[Journal Article] Impairment o starvation-induced and constitutive autophagy in Atg7-deficient mice2005
- Author(s)
  Komatsu, M., Waguri, S., Ueno, T., Murata, S., Tanida, I., Ezaki, E., Mizushima, N., Ohsumi, Y., Uchiyama, Y., Kominami, E., Tanaka, K., Chiba, T.
- Journal Title
  
  J. Cell Biol. 169
  
  Pages: 425-434
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13002008
[Journal Article] A novel protein-conjugating system for Ufml, a ubiquitin-fold modifier2004
- Author(s)
  Komatsu, M., Chiba, T., Tatsumi, K., Iemura, S., Tanida, I., Okazaki, N., Ueno, T., Kominami, E., Natsume, T., Tanaka, K.
- Journal Title
  
  EMBO J. 23
  
  Pages: 1977-1986
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13002008
[Journal Article] A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier2004
- Author(s)
  Komatsu, M., Chiba, T., Tatsumi, K., Iemura, S., Tanida, I., Okazaki, N., Ueno, T., Kominami, E., Natsume, T., Tanaka, K.
- Journal Title
  
  EMBO J. 23
  
  Pages: 1977-1986
- Data Source
  KAKENHI-PROJECT-13002008
[Journal Article] Hub1 is an essential ubiquitin-like protein without functioning as a typical modifier in fission yeast.2004
- Author(s)
  Yashiroda, H., Tanaka, K.
- Journal Title
  
  Genes to Cells 9
  
  Pages: 1189-1197
- Data Source
  KAKENHI-PROJECT-13002008
[Journal Article] Structural basis of sugar-recognizing ubiquitin ligase2004
- Author(s)
  Mizushima, T., Hirao, T., Yoshida, Y., Lee, S.J., Chiba, T., Iwai, K., Yamaguchi, Y., Kato, K., Tsukihara, T., Tanaka, K.
- Journal Title
  
  Nature Struct.& Mol.Biol. 11
  
  Pages: 365-370
- Data Source
  KAKENHI-PROJECT-13002008
[Journal Article] A novel protein-conjugating system for Ufml, a ubiquitin-fold modifier2004
- Author(s)
  Komatsu, M., Chiba, T., Tatsumi, K., Iemura, S., Tanida, I., Okazaki, N., Ueno, T., Kominami, E., Natsume, T., Tanaka, K..
- Journal Title
  
  EMBO J. 23
  
  Pages: 1977-1986
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13002008
[Journal Article] Hubl is an essential ubiquitin-like protein without functioning as a typical modifier in fission yeast2004
- Author(s)
  Yashiroda, H., Tanaka, K.
- Journal Title
  
  Genes Cells 9
  
  Pages: 1189-1197
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13002008
[Journal Article] Structural basis of sugar-recognizing ubiquitin ligase2004
- Author(s)
  Mizushima, T., Hirao, T., Yoshida, Y., Lee, S.J., Chiba, T., Iwai, K., Yamaguchi, Y., Kato, K., Tsukihara, T., Tanaka, K.
- Journal Title
  
  Nature Struct. Mol. Biol. 11
  
  Pages: 365-370
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13002008
[Journal Article] The molecular chaperone Hsp90 interacts with 26S proteasomes and regulates their a ssembly2003
- Author(s)
  Imai, J., Maruya, M., Yashiroda, H., Yahara, I., Tanaka, K.
- Journal Title
  
  EMBO J. 22
  
  Pages: 3557-3567
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13002008
[Journal Article] The molecular chaperone Hsp90 interacts with 26S proteasomes and regulates their assembly2003
- Author(s)
  Imai, J., Maruya, M., Yashiroda, H., Yahara, I., Tanaka, K.
- Journal Title
  
  EMBO J. 22
  
  Pages: 3557-3567
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13002008
[Journal Article] Parkin binds the Rpn10 subunit of 26S proteasomes with the ubiquitin-like domain2003
- Author(s)
  Sakata, E., Yamaguchi, Y., Kurimoto, E., Kikuchi, J., Yokoyama, S., Yamada, S., Kawahara, H., Yokosawa, H., Hattori, N., Mizuno, Y., Tanaka, K., Kato, K.
- Journal Title
  
  EMBO Rep. 4
  
  Pages: 301-306
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13002008
[Journal Article] Parkin binds the Rpn10 subunit of 26S proteasomes with the ubiquitin-like domain2003
- Author(s)
  Sakata, E., Yamaguchi, Y., Kurimoto, E., Kikuchi, J., Yokoyama, S., Yamada, S., Kawahara, H., Yokosawa, H., Hattori, N.Mizuno, Y., Tanaka, K., Kato, K.
- Journal Title
  
  EMBO Rep 4
  
  Pages: 301-306
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13002008
[Journal Article] Conditional knockdown of proteasomes results in cell-cycle arrest and enhanced expression of molecular chaperones Hsp70 and Hsp40 in chicken DT40 cells2003
- Author(s)
  Tanahashi-Hori, T., Tanahashi, N., Tanaka, K., Chiba, T.
- Journal Title
  
  J. Biol. Chem. 278
  
  Pages: 16237-16243
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13002008
[Journal Article] Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains2003
- Author(s)
  Yoshida, Y., Tokunaga, F., Chiba, T., Iwai, K., Tanaka, K., Tai, T.
- Journal Title
  
  J. Biol. Chem. 278
  
  Pages: 43877-43884
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13002008
[Journal Article] Two distinct pathways mediated by PA28 and hsp90 in MHC class I antigen processing2002
- Author(s)
  Yamano, T., Murata, S., Shimbara, N., Tanaka, N., Chiba, T., Tanaka, K., Yui, K., Udono, H.
- Journal Title
  
  J. Exp. Med. 196
  
  Pages: 185-196
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13002008
[Journal Article] The structure of the mammalian 20S proteasome at 2.75Å resolution2002
- Author(s)
  Unno, M., Mizushima, T., Morimoto, Y., Tomisugi, Y., Tanaka, K., Yasuoka, N., Tsukihara, T.
- Journal Title
  
  Structure 10
  
  Pages: 609-618
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13002008
[Journal Article] 26S proteasomes function as stable entities2002
- Author(s)
  Hendil, K.B., Hartmann-Petersen, R., Tanaka.K.
- Journal Title
  
  J. Mol. Biol. 315
  
  Pages: 627-636
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13002008
[Journal Article] E3 ubiquitin-ligase that recognizes sugar chains2002
- Author(s)
  Yoshida, Y., Chiba, T., Tokunaga, T., Kawasaki, H., Iwai, K., Suzuki, T., Ito, Y., Matsuoka, K., Yoshida, M., Tanaka, K., Tai, T.
- Journal Title
  
  Nature 418
  
  Pages: 438-442
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13002008
[Journal Article] The structure of the mammalian 20S proteasome at 2.75 Å resolution2002
- Author(s)
  Unno, M., Mizushima, T., Morimoto, Y., Tomisugi, Y., Tanaka, K., Yasuoka, N., Tsukihara, T.
- Journal Title
  
  Structure 10
  
  Pages: 609-618
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13002008
[Journal Article] Two distinct pathways mediated by PA28 and hsp90 in MHC class I antigen processing2002
- Author(s)
  Yamano, T., Murata, S., Shimbara, N., Tanaka, N., Chiba, T., Tanaka, K.Yui, K., Udono, H.
- Journal Title
  
  J. Exp. Med. 196
  
  Pages: 185-196
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13002008
[Journal Article] 26S proteasomes function as stable entities2002
- Author(s)
  Hendil, K.B., Hartmann-Petersen, R., Tanaka, K.
- Journal Title
  
  J. Mol. Biol. 315
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13002008
[Journal Article] CHIP is a chaperone-dependent E3 ligase that ubiquitylates unfolded protein2001
- Author(s)
  Murata, S., Minami, Y., Minami, M., Chiba, T., Tanaka, K
- Journal Title
  
  EMBO Rep. 2
  
  Pages: 1133-1138
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13002008
[Journal Article] NEDD8 recruits E2-ubiquitin to SCF E3-ligase2001
- Author(s)
  Kawakami, T., Chiba, T., Suzuki, T., Iwai, K., Yamanaka, K., Minato, N., Hidaka, Y., Shimbara, N., Suzuki, H., Osak, F., Omata, M., Tanaka, K
- Journal Title
  
  EMBO J. 20
  
  Pages: 4003-4012
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13002008
[Journal Article] Immunoproteasome assembly and antigen processing in mice lacking both PA28a and PA28b.2001
- Author(s)
  Murata, S., Udono, H., Tanahashi, N., Hamada, N., Adachi, K., Yamano, T., Yui, K., Kobayashi, N., Kawahara, M., Tanaka, K., Chiba, T.
- Journal Title
  
  EMBO J. 20
  
  Pages: 5898-5907
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13002008
[Journal Article] NEDD8 recruits E2-ubiquitin to SCF E3-ligase2001
- Author(s)
  Kawakami, T., Chiba, T., Suzuki, T., Iwai, K., Yamanaka, K., Minato, N., Hidaka, Y., Shimbara, N., Suzuki, H., Osak, F., Omata, M., Tanaka, K.
- Journal Title
  
  EMBO J. 20
  
  Pages: 4003-4012
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13002008
[Journal Article] Immunoproteasome assembly and antigen processing in mice lacking both PA28a and PA28b2001
- Author(s)
  Murata, S., Udono, H., Tanahashi, N., Hamada, N., Adachi, K., Yamano, T., Yui, K., Kobayashi, N., Kasahara, M., Tanaka, K., Chiba, T.
- Journal Title
  
  EMBO J 20
  
  Pages: 5898-5907
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13002008
[Journal Article] The NEDD8 system is essential for cell cycle progression and morphogenetic pathway in mice2001
- Author(s)
  Tateishi, K., Omata, M., Tanaka, K., Chiba, T.
- Journal Title
  
  J. Cell Biol. 155
  
  Pages: 571-580
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13002008
[Journal Article] CHIP is a chaperone- dependent E3 ligase that ubiquitylates unfolded protein2001
- Author(s)
  Murata, S., Minami, Y., Minami, M., Chiba, T., Tanaka, K.
- Journal Title
  
  EMBO Rep. 2
  
  Pages: 1133-1138
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13002008
[Journal Article] Impariment of starvation-induced and constitutive autophagy in Atg7-deficient mice.
- Author(s)
  Komatsu, M., Waguri, S., Ueno, T., Murata, S., Tanida, I., Ezaki, E., Mizushima, N., Ohsumi, Y., Uchiyama, Y., Kominami, E., Tanaka, K.K., Chiba, T.
- Journal Title
  
  J.Cell Biol. (In press)
- Data Source
  KAKENHI-PROJECT-13002008
[Journal Article] Loss of autophagy in the central nervous system causes neurodegeneration
- Author(s)
  Komatsu, M., Waguri, S., Chiba, T., Murata, S., Iwata, J., Ueno, T., Koike, M., Uchiyama, Y., Kominami, E., Tanaka, K.
- Journal Title
  
  Nature (in press)(Published online 19 April 2006, doi:10.1038/ nature 04723).
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13002008
[Journal Article] Loss of autophagy in the central nervous system causes neurodegeneration
- Author(s)
  Komatsu, M., Waguri, S., Chiba, T., Murata, S., Iwata, J., Ueno, T., Koike, M., Uchiyama, Y., Kominami, E., Tanaka, K
- Journal Title
  
  Nature (Published online 19 April 2006, doi : 10.1038/nature 04723). (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13002008
[Patent] ポリユビキチン化基質の同定方法2014
- Inventor(s)
  吉田雪子、佐伯泰、土屋光、村上有沙、田中啓二
- Industrial Property Rights Holder
  (公財)東京都医学総合研究所
- Filing Date
  2014-11-13
- Data Source
  KAKENHI-PROJECT-26000014
[Patent] A novel versatile method for determining ubiuuitin chain length reveals functional units of polyyubiguitin chains in cells2013
- Inventor(s)
  佐伯泰, 土屋光, 海保愛, 田中啓二
- Industrial Property Rights Holder
  (公財)東京都医学総合研究所
- Industrial Property Rights Type
  特許
- Filing Date
  2013-11-08
- Overseas
- Data Source
  KAKENHI-PROJECT-21000012
[Patent] A novel versatile method for determining ubiquitin chain length reveals functional units of polyyubiquitin chains in cells2013
- Inventor(s)
  佐伯泰、土屋光、海保愛、田中啓二
- Industrial Property Rights Holder
  (公財)東京都医学総合研究所
- Filing Date
  2013-11-08
- Overseas
- Data Source
  KAKENHI-PROJECT-21000012
[Patent] ポリユビキチン化基質の同定方法2013
- Inventor(s)
  吉田雪子, 佐伯泰, 土屋光, 村上有沙, 田中啓二
- Industrial Property Rights Holder
  (公財)東京都医学総合研究所
- Industrial Property Rights Type
  特許
- Filing Date
  2013-11-15
- Data Source
  KAKENHI-PROJECT-21000012
[Patent] ポリユビキチン化基質の同定方法2013
- Inventor(s)
  吉田雪子、佐伯泰、土屋光、村上有沙、田中啓二
- Industrial Property Rights Holder
  (公財)東京都医学総合研究所
- Filing Date
  2013-11-15
- Data Source
  KAKENHI-PROJECT-21000012
[Patent] 条件的自食作用欠損動物及び疾患モデル動物2011
- Inventor(s)
  田中啓二、千葉智樹、小松雅明
- Industrial Property Rights Holder
  (公財)東京都医学総合研究所
- Acquisition Date
  2011-05-27
- Data Source
  KAKENHI-PROJECT-21000012
[Patent] 肝疾患治療薬2011
- Inventor(s)
  田中啓二、小松雅明、丹羽眞一郎、牧野泰孝、笠間隆志
- Industrial Property Rights Holder
  (公財)東京都医学総合研究所
- Filing Date
  2011-07-14
- Data Source
  KAKENHI-PROJECT-21000012
[Patent] 条件的自食作用欠損動物及び疾患モデル動物2003
- Inventor(s)
  田中啓二, 千葉智樹, 小松雅明
- Industrial Property Rights Holder
  (財)東京都医学研究機構
- Filing Date
  2003-06-20
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13002008
[Presentation] Proteo- and Organello-stasis Linked to Neurodegeneration2022
- Author(s)
  Keiji TANAKA
- Organizer
  JSN 63rd Annual Meeting Commemorative Lecture
- Invited
- Data Source
  KAKENHI-PROJECT-19H00997
[Presentation] 私のプロテアソーム研究～温故知新～2022
- Author(s)
  田中啓二
- Organizer
  先端モデル動物支援プラットフォーム (AdAMS) 成果発表会
- Invited
- Data Source
  KAKENHI-PROJECT-19H00997
[Presentation] オートファジーと栄養2022
- Author(s)
  田中啓二
- Organizer
  第8回アジア栄養士会議：教育講演I
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H00419
[Presentation] Autophagy and Nutrition2022
- Author(s)
  Keiji TANAKA
- Organizer
  The 8th Asian Congress of Dietetics
- Invited
- Data Source
  KAKENHI-PROJECT-19H00997
[Presentation] 神経変性疾患に関連したプロテオスタシスとオルガネラスタシス2022
- Author(s)
  田中啓二
- Organizer
  第63回日本神経学会学術大会：記念講演
- Invited
- Data Source
  KAKENHI-PROJECT-22H00419
[Presentation] 基礎研究余話「役に立たない研究」と「役に立つ研究」2022
- Author(s)
  田中啓二
- Organizer
  日本学術会議主催学術フォーラム国際基礎科学年（IYBSSD2022）～持続可能な世界のために
- Invited
- Data Source
  KAKENHI-PROJECT-19H00997
[Presentation] プロテアソームの基礎から医学研究へ2022
- Author(s)
  田中啓二
- Organizer
  日本臨床ストレス応答学会第16回大会
- Invited
- Data Source
  KAKENHI-PROJECT-19H00997
[Presentation] オートファジーと栄養2022
- Author(s)
  田中啓二
- Organizer
  第39回日本微量栄養素学会
- Invited
- Data Source
  KAKENHI-PROJECT-19H00997
[Presentation] オートファジーとプロテアソーム2022
- Author(s)
  田中啓二
- Organizer
  第39回日本微量栄養素学会学術集会：特別講演
- Invited
- Data Source
  KAKENHI-PROJECT-22H00419
[Presentation] プロテアソームの基礎から医学研究へ2022
- Author(s)
  田中啓二
- Organizer
  第16回日本臨床ストレス応答学会：特別講演
- Invited
- Data Source
  KAKENHI-PROJECT-22H00419
[Presentation] プロテアソーム～基礎から医学研究へ～2021
- Author(s)
  田中啓二
- Organizer
  星薬科大学先端生命科学研究所 Webシンポジウム「新しい薬のモダリティ」
- Invited
- Data Source
  KAKENHI-PROJECT-19H00997
[Presentation] プロテアソーム～基礎から医学研究へ～2021
- Author(s)
  田中啓二
- Organizer
  第101回北海道医学大会総会
- Invited
- Data Source
  KAKENHI-PROJECT-19H00997
[Presentation] プロテアソーム～基礎から最先端研究へ～2021
- Author(s)
  田中啓二
- Organizer
  第3回ヒトレトロウイルス学共同研究セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19H00997
[Presentation] プロテアソーム～基礎から最先端研究へ～2020
- Author(s)
  田中啓二
- Organizer
  第29回泌尿器科分子・細胞研究会：未知との遭遇～基礎研究は楽しい～イブニングセミナー2
- Invited
- Data Source
  KAKENHI-PROJECT-19H00997
[Presentation] プロテアソーム～基礎から医学応用へ～2020
- Author(s)
  田中啓二
- Organizer
  第24回日本がん分子標的治療学会（基調講演 1）
- Invited
- Data Source
  KAKENHI-PROJECT-19H00997
[Presentation] プロテアソーム～選択的なタンパク質リサイクルシステム～2020
- Author(s)
  田中啓二
- Organizer
  第13回オートファジー研究会
- Invited
- Data Source
  KAKENHI-PROJECT-19H00997
[Presentation] タンパク質分解：プロテアソームとオートファジー2020
- Author(s)
  田中啓二
- Organizer
  第24回日本肝臓学会大会：特別講演
- Invited
- Data Source
  KAKENHI-PROJECT-19H00997
[Presentation] Phase Separated Proteasome Condensates: For Nuclear Proteolysis.2019
- Author(s)
  Keiji Tanaka
- Organizer
  Joint Annual Meeting of 71st JSCB & 19th PSSJ, Joint Symposium. Emerging concepts of protein science: From nanoscale to cells
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H00997
[Presentation] 蛋白質科学の新常識 : ナノスケールから細胞まで2019
- Author(s)
  S. Yasuda, H. Tsuchiya, Y. Saeki, and K. Tanaka
- Organizer
  第19回日本蛋白質科学会年会・第71回日本細胞生物学会大会、合同企画シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] Phase Separated Proteasome Condensates : For Nuclear Proteolysis2019
- Author(s)
  Keiji Tanaka
- Organizer
  Joint Annual Meeting of 71st JSCB & 19th PSSJ, Joint Symposium. Emerging concepts of protein science : From nanoscale to cells
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] プロテアソーム～相分離が拓く新しいタンパク質分解機構～2019
- Author(s)
  田中啓二
- Organizer
  第二回形態解析ワークショップー多様な顕微鏡を用いて
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] 細胞内恒常性機能維持機構とがん・老化関連疾患. 「肺線維症における細胞老化の意義と治療的応用」2019
- Author(s)
  田中啓二
- Organizer
  第4回肺トランスレーショナルメデイシン研究会
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] The Proteasome - Action Mechanisms and Spatiotemporal Dynamics2019
- Author(s)
  Keiji Tanaka
- Organizer
  Ken-ichi Arai Memorial Symposium
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] プロテアソーム～相分離が拓く新しいタンパク質分解機構～2019
- Author(s)
  田中啓二
- Organizer
  第二回　形態解析ワークショップ－多様な顕微鏡を用いて
- Invited
- Data Source
  KAKENHI-PROJECT-19H00997
[Presentation] The Proteasome : Stress and Phase Separation2019
- Author(s)
  Keiji Tanaka
- Organizer
  NIH-Japan-JSPS Symposium: Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H00997
[Presentation] 細胞内恒常性機能維持機とがん・老化関連疾患.2019
- Author(s)
  田中啓二
- Organizer
  第4回肺トランスレーショナルメデイシン研究会「肺線維症における細胞老化の意義と治療的応用」
- Invited
- Data Source
  KAKENHI-PROJECT-19H00997
[Presentation] The Proteasome　～ Action Mechanisms and Spatiotemporal Dynamics ～2019
- Author(s)
  Keiji Tanaka
- Organizer
  Ken-ichi Arai Memorial Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H00997
[Presentation] The Proteasome : Stress and Phase Separation2019
- Author(s)
  Keiji Tanaka
- Organizer
  NIH-Japan-JSPS Symposium : Symposium Theme : Inflammation
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] これから科学者を目指す君たちへ2018
- Author(s)
  田中啓二
- Organizer
  秋田大学市民講演会
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] ユビキチンとプロテアソーム～基礎から医学研究へ～.2018
- Author(s)
  田中啓二
- Organizer
  国立国際医療研究センター研究所(NCGMRI)“冬期リトリート”
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] The Proteasome～Structure and Immunological Roles～2018
- Author(s)
  Keiji Tanaka
- Organizer
  The XVI International Symposium on Amyloidosis (ISA2018)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] Spatio-temporal Dynamics of Human Proteasomes in Stress Responses2018
- Author(s)
  Keiji Tanaka
- Organizer
  The 8th Proteasome and Autophagy Workshop
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] Assembly and Spatio-temporal Dynamics2018
- Author(s)
  Keiji Tanaka
- Organizer
  24th IUBMB-15th FAOBMB Congress, N. Protein modification and regulation (4) [SY1-1] PTM in Cell Signaling
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] プロテアソーム～動作原理から生理機能～2018
- Author(s)
  田中啓二
- Organizer
  新潟大学医学部セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] プロテアソーム～四半世紀の研究を回想する～2018
- Author(s)
  田中啓二
- Organizer
  徳島大学先端酵素学研究所設立記念シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] The Proteasome ～Action Mechanisms and Physiology～2018
- Author(s)
  Keiji Tanaka
- Organizer
  Advanced Forum on Protein Sciences in Beijing
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] Parkin - Overview.2018
- Author(s)
  Keiji Tanaka
- Organizer
  The 41st Annual Meeting of the Japan Neuroscience Society on New Horizon of Neuroscience, “Parkin” 20th anniversary International symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] The Proteasome ～Structure and Spatiotemporal Dynamics～2018
- Author(s)
  Keiji Tanaka
- Organizer
  Asian Pacific Prion Symposium 2018 (APPS2018)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] プロテアソーム～選択的なタンパク質リサイクルシステム～2018
- Author(s)
  田中啓二
- Organizer
  自治医科大学大学院医学研究科開設40周年記念事業
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] The Proteasome ～Assembly and Spatiotemporal Dynamics～2018
- Author(s)
  Keiji Tanaka
- Organizer
  International Symposium on “Proteins : from the Cradle to the Grave”
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] Cell-mediated Immunity govern by Immunoproteasome and Thymoproteasome, “Ubiquitin Family, Autophagy and Diseases”2018
- Author(s)
  Keiji Tanaka
- Organizer
  Cold Spring Harbor Asia Conference (CSH Asia)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] プロテアソーム～もう一つのタンパク質リサイクルシステム2017
- Author(s)
  田中啓二
- Organizer
  ～東工大栄誉教授・大隅良典氏ノーベル賞受賞記念「七人の侍」講演会
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] タンパク質分解と生命医科学研究2017
- Author(s)
  田中啓二
- Organizer
  平成28年度東京都医師会功労賞表彰式および医学研究賞・グループ研究賞受賞記念講演会
- Place of Presentation
  東京都医師会館(東京都千代田区)
- Year and Date
  2017-02-25
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] プロテアソームを手探りに免疫の世界を楽しむ2017
- Author(s)
  田中啓二
- Organizer
  第19回免疫サマースクール in 湘南
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] タンパク質リサイクルシステム～プロテアソームとオートファジー2017
- Author(s)
  田中啓二
- Organizer
  ～ライフサイエンスイノベーション発信セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] Emerging Role of Thymoproteasomes in (Adaptive) Immunity.2017
- Author(s)
  Keiji Tanaka
- Organizer
  Sorak Conference on Protein Metabolism and Degradation
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] 私のプロテアソーム研究～幸運と不運の間で～2017
- Author(s)
  田中啓二
- Organizer
  第44回神戸ラボ全体研究会議
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] The Proteasome : Overview of the Structure and Functions2017
- Author(s)
  田中啓二
- Organizer
  ConBio2017 Consortium of Biological Sciences 2017
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] プロテアソームとオートファジー2017
- Author(s)
  田中啓二
- Organizer
  第22回日本病態プロテアーゼ学会学術集会教育講演
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] 細胞内リサイクルシステム～プロテアソームとオートファジー2017
- Author(s)
  田中啓二
- Organizer
  ～製薬コンソ・AMED共催創薬コンソ分野別研究会
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] プロテアソーム～基礎研究が未来を拓く～2017
- Author(s)
  田中啓二
- Organizer
  第1回日本医療研究開発大賞受賞記念講演
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] プロテアソームと適応(細胞性)免疫2017
- Author(s)
  田中啓二
- Organizer
  第14回Osteoimmunology Forum
- Place of Presentation
  ステーションコンファレンス東京(東京都千代田区)
- Year and Date
  2017-02-11
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] 免疫型プロテアソームによる Antigen processingと“自己と非自己の識別”機構2016
- Author(s)
  田中啓二
- Organizer
  第25回日本組織適合性学会 : MHC研究の進歩 : 生命科学と臨床医学へのインパクト
- Place of Presentation
  北海道大学学術交流会館(北海道札幌市)
- Year and Date
  2016-10-22
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] Ubiquitin chain-type selectivity of ubiquitin-binding proteins in yeast2016
- Author(s)
  Keiji Tanaka
- Organizer
  Ubiquitin Family, Autophagy and Diseases Cold Spring Harbor Asia Conference (CSH Asia)
- Place of Presentation
  Suzhou, China
- Year and Date
  2016-04-18
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] 研究と教育～組織改革への期待～2016
- Author(s)
  田中啓二
- Organizer
  「変わる徳島大学」学部新設・改組及び新研究所設置記念式典・記念講演会
- Place of Presentation
  徳島グランヴィリオホテル・グランヴィリオホール(徳島県徳島市)
- Year and Date
  2016-04-11
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] Spatio-temporal Dynamics of the Human Proteasome in Stress Responses2016
- Author(s)
  Keiji Tanaka
- Organizer
  FASEB “Ubiquitin & Cellular Regulation”
- Place of Presentation
  Big Sky Resort Huntley Lodge 50 Big Sky Resort Road Big Sky MT, USA
- Year and Date
  2016-06-12
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] 半端なベクトルに出口無し!～徹底した基礎研究から広がる応用～「黎明期のプロテアソーム研究」2016
- Author(s)
  田中啓二
- Organizer
  第39回分子生物学会(MBSJ)年会プレナリーモーニングセミナー
- Place of Presentation
  パシフィコ横浜(神奈川県横浜市)
- Year and Date
  2016-12-02
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] ～タンパク質のゆりかごから墓場まで～「プロテアソーム“自己と非自己”識別の根源に迫る!」2016
- Author(s)
  田中啓二
- Organizer
  京都産業大学「タンパク質動態研究所」開設記念シンポジウム
- Place of Presentation
  京都産業大学講堂(京都府京都市)
- Year and Date
  2016-10-26
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] Thymoproteasome : The Key Player in Positive Selection of CD8+ T cells2016
- Author(s)
  Keiji Tanaka
- Organizer
  The 7th Proteasome and Autophagy Workshop
- Place of Presentation
  Clermont-Ferrand, France
- Year and Date
  2016-04-06
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] “変わる徳島大学” : 「研究と教育～組織改革への期待～」2016
- Author(s)
  田中啓二
- Organizer
  学部新設・改組及び新研究所設置記念式典・記念講演会
- Place of Presentation
  徳島グランヴィリオホール(徳島県徳島市)
- Year and Date
  2016-04-11
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] 私のブロテアソーム研究～幸運と不運に彩られて～2016
- Author(s)
  田中啓二
- Organizer
  第121回日本解剖学会総会・全国学術集会
- Place of Presentation
  ビッグパレットふくしま(福島県郡山市)
- Year and Date
  2016-03-28
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] Ubiquitin Chain-type. 「Selectivity of Ubiquitin-binding Proteins in Yeast」2016
- Author(s)
  Keiji Tanaka
- Organizer
  Ubiquitin Family, Autophagy and Disease. Cold Spring Harbor Asia Conference (CSH Asia)
- Place of Presentation
  Suzhou, China
- Year and Date
  2016-04-18
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] 私のプロテアソーム研究2016
- Author(s)
  田中啓二
- Organizer
  89回日本生化学会大会～生化学の創造的復興～ Meet the Expert.
- Place of Presentation
  仙台国際センター(宮城県仙台市)
- Year and Date
  2016-09-27
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] タンパク質分解～辺境領域から生命科学の中枢へ～2015
- Author(s)
  田中啓二
- Organizer
  第8回「酵素学研究拠点」シンポジウム : タンパク質代謝・分解系の酵素学「文化功労者」顕彰記念講演
- Place of Presentation
  徳島大学藤井節郎記念ホール、徳島県徳島市
- Year and Date
  2015-02-10
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] タンパク質分解～辺境領域から生命科学の中枢へ～2015
- Author(s)
  田中啓二
- Organizer
  国立医薬品食品衛生研究所講演
- Place of Presentation
  国立医薬品食品衛生研究所(東京都世田谷区)
- Year and Date
  2015-09-04
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] Basic Mechanisms and Physiopathology of The Proteasome2015
- Author(s)
  Keiji Tanaka
- Organizer
  IMP (Research Institute of Molecular Pathology) Lecture
- Place of Presentation
  Vienna Biocenter, Austria
- Year and Date
  2015-07-09
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] 栄養学における基礎科学と応用科学の統合2015
- Author(s)
  田中啓二
- Organizer
  日本栄養士会・研究教育事業部・全国研修会の基調講演
- Place of Presentation
  東京農業大学、東京都世田谷区
- Year and Date
  2015-03-07
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] In-depth Analyses of Thymoproteasomes -Positive Selection of CD8+ T cells-2015
- Author(s)
  Keiji Tanaka
- Organizer
  Ubiquitin and Ubiquitin-like modifiers : From molecular mechanisms and human diseases (2nd EMBO Ubiquitin Conference Series)
- Place of Presentation
  I Cavtat, Croatia
- Year and Date
  2015-09-18
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] Ubiquitin : lst Mitophagy driven by PINKI, Parkin and Ubiquitin, 2nd MS and TR-Tube Strategy for Ubiquitin Code Analysis2015
- Author(s)
  Keiji Tanaka
- Organizer
  The 2nd Ubiquitin Symposium at Hotel Stefani e
- Place of Presentation
  Vienna Biocenter, Austria
- Year and Date
  2015-07-10
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] 「細胞内の蛋白質の一生 : 新生から死に至るまで」 : タンバク質分解装置“ブロテアソーム”の動態と作動機構2015
- Author(s)
  田中啓二
- Organizer
  第15回日本蛋白質科学会年会シンポジウム
- Place of Presentation
  あわぎんホール(徳島県徳島市)
- Year and Date
  2015-06-24
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] 栄養学における基礎科学と応用科学の統合2015
- Author(s)
  田中啓二
- Organizer
  徳島大学栄養学科同窓会(栄友会)東日本支部(文化功労者顕彰記念)同窓会セミナー
- Place of Presentation
  昭和女子大学(東京都世田谷区)
- Year and Date
  2015-06-27
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] 生化学の立場から～タンパク質の新陳代謝～2014
- Author(s)
  田中啓二
- Organizer
  第61回日本栄養改善学会学術集会「栄養学-新たな挑戦日本栄養改善学会60周年シンポジウム」
- Place of Presentation
  パシフィコ横浜、神奈川県横浜市
- Year and Date
  2014-08-21
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] プロテアソーム : 動作原理から炎症免疫疾患制御への展望2014
- Author(s)
  田中啓二
- Organizer
  第35回日本炎症・再生医学会 : 教育講演
- Place of Presentation
  万国津梁館、沖縄(発表確定)
- Invited
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] 私のプロテアソーム研究を回想して…2014
- Author(s)
  田中啓二
- Organizer
  第66回細胞生物学会大会 S11 七人の侍からのメッセージ～私の仕事を通じて若者達に伝えたきこと～
- Place of Presentation
  奈良県新公会堂・東大寺総合文化センター、奈良(発表確定)
- Invited
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] 神経変性疾患の謎を解く―タンパク分解系からのアプローチ2014
- Author(s)
  田中啓二
- Organizer
  第37回日本神経科学会Neuroscience2014, 教育講演
- Place of Presentation
  パシフィコ横浜、横浜(発表確定)
- Invited
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] 神経変性疾患の謎を解く-タンパク分解系からのアフローチー-2014
- Author(s)
  田中啓二
- Organizer
  第37回日本神経科学大会(Neuroscience 2014)「神経科学が世界を変える」教育講演
- Place of Presentation
  パシフィコ横浜, 神奈川県横浜市
- Year and Date
  2014-09-13
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] タンパク質の新陳代謝～健康と病気のみなもと～2014
- Author(s)
  田中啓二
- Organizer
  サイエンステクノフロンティアフォーラムサイテックサロン
- Place of Presentation
  駒場ファカルティハウス(東京大学駒場キャンパス内、)東京(発表確定)
- Year and Date
  2014-06-28
- Invited
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] 私のプロテアソーム研究～成功と失敗のエピソード～2014
- Author(s)
  田中啓二
- Organizer
  新学術領域「ユビキチンネオバイオロジー」領域班会議 -文化功労者 -顕彰記念講演
- Place of Presentation
  ホテルたつき、愛知県蒲郡市
- Year and Date
  2014-12-04
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] 私のプロテアソーム研究～偶然が必然を誘う幸運～2014
- Author(s)
  田中啓二
- Organizer
  免疫サマースクール
- Place of Presentation
  オリビアン小豆島、香川県小豆島
- Year and Date
  2014-07-29
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] Basic mechanisms and physiopathological roles of eukaryotic proteasomes2014
- Author(s)
  Keiji Tanaka
- Organizer
  A lecture in "Karolinska Research Lectures" series at Nobel Forum
- Place of Presentation
  Stockholm, Sweden(発表確定)
- Year and Date
  2014-09-18
- Invited
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] Basic mechanisms and physiopathological roles of eukaryotic proteasomes.2014
- Author(s)
  K. Tanaka
- Organizer
  A lecture in "Karolinska Research Lectures" series at Nobel Forum
- Place of Presentation
  Stockholm, (Sweden)
- Year and Date
  2014-09-18
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] Oxidative Stress, Mitophagy, and the PINK1-Parkin System2014
- Author(s)
  Keiji Tanaka
- Organizer
  Symposium 17 on Oxidative Stress and Autophagy. 17th Biennial Meeting of Society for Free Radical Research International (SFRRI 2014)
- Place of Presentation
  Kyoto International Conference Center, Kyoto, Japan
- Year and Date
  2014-03-26
- Invited
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] タンパク質の新陳代謝～健康と病気のみなもと～2014
- Author(s)
  田中啓二
- Organizer
  「サイエンステクノフロンティアフォーラム」サイテックサロン
- Place of Presentation
  駒場ファカルティハウス(東京大学駒場キャンパス内)、東京都目黒区
- Year and Date
  2014-06-28
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] The vertebrate-specific thymoproteasome governs positive selection in the development of CD8 T lymphocytes2014
- Author(s)
  Keiji Tanaka
- Organizer
  The Zomes VIII Conference, Biology of the Zomes-Proteasome, COP9 Signalosome and associated processes.
- Place of Presentation
  Xiamen, China(発表確定)
- Invited
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] 私のフロテアソーム研究～成功と失敗のエピソード～2014
- Author(s)
  田中啓二
- Organizer
  国立国際医療研究センター研究所セミナー
- Place of Presentation
  国立国際医療研究センター、東京都新宿区
- Year and Date
  2014-12-08
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] The PINK1-Parkin system controls mitochondrial homeostasis to suppress the cause of 'Parkinson's disease.2014
- Author(s)
  Keiji Tanaka
- Organizer
  "KSU International Symposium : Cutting-edge of Life Sciences".
- Place of Presentation
  Kyoto, Japan(発表確定)
- Invited
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] Thymoproteasomes play an essential role for the formation of immunocompetent repertoire of CD8 T cells2014
- Author(s)
  Keiji Tanaka
- Organizer
  EMBO Conference on Ubiquitin & ubiquitin-like proteins : At the crossroads from chromatin to protein.
- Place of Presentation
  Buenos Aires, Argentina(発表確定)
- Invited
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] 生化学の立場から2014
- Author(s)
  田中啓二
- Organizer
  第61回日本栄養改善学会学術集会8/21メインシンポジウムI「栄養学―新たな挑戦日本栄養改善学会60周年シンポジウム」
- Place of Presentation
  パシフィコ横浜、横浜(発表確定)
- Invited
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] Basic Mechanisms and Physiopathological Roles of Eukaryotic Proteasomes2014
- Author(s)
  Keiji Tanaka
- Organizer
  Nobel Forum Lecture
- Place of Presentation
  Karolinska Institute, Stockholm, SWEDEN
- Year and Date
  2014-09-18
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] Surveillance of Mitochondrial Homeostasis by the PINK1-Parkin System2014
- Author(s)
  Keiji Tanaka
- Organizer
  The 87th Annual Meeting of the Japanese Biochemical Society New Phase in Organelle Biology : Cellular Organellostasis with Mitochondria as a Hub
- Place of Presentation
  Kyoto International Conference Center, Kyoto
- Year and Date
  2014-10-15
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] Physiopathological Roles of the Immune-dedicated Proteasomes in Vertebrate.2013
- Author(s)
  Keiji Tanaka
- Organizer
  The Second Immunology Symposium of The University of Tokushima“Immune Development, Deviation, and Regulation”
- Place of Presentation
  Nichia Medical Hall, Tokushima University Hospital, Tokushima
- Invited
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] Pathophysiological Roles of the Proteasome in Vertebrate.2013
- Author(s)
  Keiji Tanaka
- Organizer
  The EUROMEDLAB Milano 2013 Congress. [OPENING LECTURE]
- Place of Presentation
  Milano Convention Center, Milano, Italy.
- Year and Date
  2013-05-19
- Invited
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] オートファジーKOマウスとその応用2013
- Author(s)
  田中啓二, 小松雅明
- Organizer
  BioJapan 2013 World Business Forum
- Place of Presentation
  パシフィコ横浜、横浜
- Year and Date
  2013-10-11
- Invited
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] プロテアソーム―発見から四半世紀の軌跡―2013
- Author(s)
  Keiji Tanaka
- Organizer
  大阪大学生命機能研究科研究交流会Frontier Bioscience Colloquium特別講演
- Place of Presentation
  大阪
- Year and Date
  2013-05-29
- Invited
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] 二つの免疫型プロテアソームの発見-偶然から免疫学の檜舞台へ-2013
- Author(s)
  田中啓二
- Organizer
  15th免疫サマースクール2013 in Hakata
- Place of Presentation
  福岡
- Year and Date
  2013-07-31
- Invited
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] The Ubiquitin-Proteasome System.2013
- Author(s)
  Keiji Tanaka
- Organizer
  HUPO 2013 Congress in Yokohama Proteomics of Protein Degradation : Session 11. Keynote Lecture
- Place of Presentation
  Yokohama, Japan
- Year and Date
  2013-09-16
- Invited
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] プロテアソームの発見から現在に至る研究の軌跡.2013
- Author(s)
  田中啓二
- Organizer
  第29回前立腺シンポジウム : 教育セミナー1
- Place of Presentation
  東京コンファレンスセンター・品川、東京
- Year and Date
  2013-12-14
- Invited
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] ミトコンドリアストレスとユビキチン・プロテアソームシステム2013
- Author(s)
  田中啓二
- Organizer
  第8回臨床ストレス応答学会
- Place of Presentation
  信州大学医学部、松本
- Year and Date
  2013-11-16
- Invited
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] Proteasome-over a quarter of a century from its discoveryプロテアソーム-その発見から四半世紀の軌跡2013
- Author(s)
  田中啓二
- Organizer
  The 86th Annual Meeting of the Japanese Biochemical Society Globalizing Biochemistry's Future. Plenary Lecture
- Place of Presentation
  Yokohama (Japan)
- Year and Date
  2013-09-13
- Invited
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] In vivo interplay between the proteasome and autophagy in the mouse liver.2013
- Author(s)
  Keiji Tanaka
- Organizer
  The 35th Naito Conference entitled The Ubiquitin-Proteasome. System : From Basic Mechanisms to Pathophysiological Roles.
- Place of Presentation
  Chateraise Gateaux Kingdom, Sapporo, Japan.
- Invited
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] The Keap1-Nrf2 activation during selective autophagy : its implication in tumor development.2013
- Author(s)
  Keiji Tanaka and Masaaki Komatsu
- Organizer
  The 72nd Annual Meeting of Japanese Cancer Association Cancer research providing hope to fight against cancer Pacifico Yokohama Symposium 10 on Autophagy in Cancer.
- Place of Presentation
  Yokohama, Japan
- Year and Date
  2013-10-03
- Invited
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] Selective Autophagy, Mitochondria, and Tumor Development2013
- Author(s)
  Keiji Tanaka
- Organizer
  The 4th International Symposium on Dynamics of Mitochondria (DynaMito 2013)
- Place of Presentation
  Okinawa Zanpamisaki Royal Hotel, Okinawa, Japan
- Invited
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] 私のプロテアソーム研究～成功と失敗の狭間で…2013
- Author(s)
  田中啓二
- Organizer
  新学術研究「修飾シグナル病」第2回若手ワークショップ別講演
- Place of Presentation
  伊香保温泉:雨情の湯森秋旅館、群馬
- Year and Date
  2013-10-22
- Invited
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] Pathophysiological roles of the proteasome in vertebrate2013
- Author(s)
  K. Tanaka
- Organizer
  The EUROMEDLAB Milano 2013 Congress
- Place of Presentation
  Milano Convention Center, Milano (Italy)
- Year and Date
  2013-05-19
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] オートファジーとミトコンドリア・ストレス　～その破綻による重篤疾病の発症機構～2012
- Author(s)
  田中啓二
- Organizer
  第65回日本酸化ストレス学会学術集会
- Place of Presentation
  あわぎんホール徳島郷土文化会館、徳島
- Invited
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] Pathophysiological roles of immuno-typed proteasomes in vertebrate2012
- Author(s)
  K. Tanaka
- Organizer
  ZOMES VII"Ubiquitin family proteins and their cognate PCI complexes"Munich
- Place of Presentation
  Germany
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] Naratriptan ameliorates SBMA pathology by the repression of CGRP1-activated JNK pathway2012
- Author(s)
  Minamiyama M, Katsuno M, Adachi H, Doi H, Kondo N, Iida M, Ishigaki S, Fujioka Y, Matsumoto S, Miyazaki Y, Tanaka F, Kurihara H, Sobue G
- Organizer
  Neuroscience 2012
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-21229011
[Presentation] 巨大で複雑な超分子複合体の構造生命科学-プロテアソームを例とした動態解明-2012
- Author(s)
  田中啓二
- Organizer
  学術会議シンポジウム「先端的異分野融合を核とした構造生命科学の飛躍に向けて」
- Place of Presentation
  日本学術会議講堂、東京(招待講演)
- Year and Date
  2012-01-09
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] Naratriptan ameliorates SBMA pathology by the repression of CGRP1-activated JNK pathway.2012
- Author(s)
  Minamiyama, M., Katsuno, M., Adachi, H., Doi, H., Kondo, N., Iida, M., Ishigaki, S., Fujioka, Y., Matsumoto, S., Miyazaki, Y., Tanaka, F., Kurihara, H., Sobue, G.
- Organizer
  Neuroscience 2012.
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-21229011
[Presentation] PINK1/Parkinによるミトコンドリアの品質管理機構～パーキンソン病の発症機構に挑む～2012
- Author(s)
  田中啓二
- Organizer
  九州大学グローバルCOEプログラム理医連携特別講演会:独創的研究の世界発信を続ける「7人の侍」コラボステーションI
- Place of Presentation
  九州大学・視聴覚ホール、福岡(招待講演)
- Year and Date
  2012-02-29
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] p62/SQSTM1 removes toxic mutant androgen receptor in spinal bulbar muscular atrophy model mouse2012
- Author(s)
  Adachi H, Doi H, Katsuno M, Matsumoto S, Kondo N, Miyazaki Y, Tohnai G, Iida M, Tanaka F, Sobue G
- Organizer
  Neuroscience 2012
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-21229011
[Presentation] プロテアソーム～構造から見た作動・形成機構～2012
- Author(s)
  田中啓二
- Organizer
  平成23年度ターゲットタンパク研究プロジェクト公開シンポジウム「ターゲットタンパク研究から見える未来5」
- Place of Presentation
  学術会議、東京(招待講演)
- Year and Date
  2012-03-12
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] The PINK1/Parkin pathway controls mitochondrial homeostasis whose collapse causes Parkinson's disease Gordon Research Conference (GRC)2012
- Author(s)
  K.Tanaka
- Organizer
  Neurobiology of Brain Disorders Stonehill College
- Place of Presentation
  Easton, MA (USA)
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] Physiopathological Roles of The Vertebrate- Specific Immuno-type Proteasomes.2012
- Author(s)
  Keiji Tanaka
- Organizer
  The Centennial of Hashimoto Disease：Symposium II Autoimmune Diseases - Etiology and Therapeutics
- Place of Presentation
  Fukuoka, Japan
- Invited
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] The PINK1/Parkin pathway controls mitochondrial homeostasis whose collapse causes Parkinson’s disease2012
- Author(s)
  Keiji Tanaka
- Organizer
  Gordon Research Conference (GRC) Neurobiology of Brain Disorders
- Place of Presentation
  Stonehill College, Easton, MA,（August 5-12, 2012）USA
- Invited
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] p62/SQSTM1 removes toxic mutant androgen receptor in spinal bulbar muscular atrophy model mouse.2012
- Author(s)
  Adachi, H., Doi, H., Katsuno, M., Matsumoto, S., Kondo, N., Miyazaki, Y., Tohnai, G., Iida, M., Tanaka, F., Sobue, G.
- Organizer
  Neuroscience 2012.
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-21229011
[Presentation] Mitochondrial Quality Control by The PINK1-Parkin System whose collapse causes Parkinson’s Disease.2012
- Author(s)
  Keiji Tanaka
- Organizer
  6th International Symposium on Autophagy (ISA 2012)
- Place of Presentation
  Okinawa, Japan
- Invited
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] Viral delivery of miR-196a ameliorates the SBMA phenotype via the silencing of CELF2.2012
- Author(s)
  Miyazaki, Y., Adachi, H., Katsuno, M., Tanaka, F., Muramatsu, S.I., Sobue, G.
- Organizer
  Neuroscience 2012.
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-21229011
[Presentation] Discovery and pathophysiology of immuno-typed proteasomes2012
- Author(s)
  K. Tanaka
- Organizer
  Goldberg Lab Reunion and Symposium Joseph B. Markin Conference Center Harvard Medical School
- Place of Presentation
  USA
- Year and Date
  2012-09-14
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] Viral delivery of miR-196a ameliorates the SBMA phenotype via the silencing of CELF22012
- Author(s)
  Miyazaki Y, Adachi H, Katsuno M, Tanaka F, Muramatsu SI, Sobue G
- Organizer
  Neuroscience 2012
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-21229011
[Presentation] Pathophysiological Roles of Immuno-typed Proteasomes in Vertebrate.2012
- Author(s)
  Keiji Tanaka
- Organizer
  ZOMES VII“Ubiquitin family proteins and their cognate PCI complexes”
- Place of Presentation
  Munich, German
- Invited
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] Cell cycle dysregulation in motor neurons of spinal and bulbar muscular atrophy (SBMA)2012
- Author(s)
  Katsuno M, Adachi H, Kondo N, Minamiyama M, Doi H, Matsumoto S, Miyazaki Y, Iida M, Nakatsuji H, Tanaka F, Sobue G
- Organizer
  23rd International Symposium on ALS/MND
- Place of Presentation
  Chicago, USA
- Data Source
  KAKENHI-PROJECT-21229011
[Presentation] Heat shock factor-1(HSF-1) influences distribution of pathogenic androgen receptor aggregations in model mouse of spinal and bulbar muscular atrophy (SBMA).2011
- Author(s)
  Kondo N, Katsuno M, Adachi H, Minamiyama M, Doi H, Matsumoto S, Miyazaki Y, Iida M, Tanaka F, Sobue G.
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  パシフィコ横浜（神奈川）
- Data Source
  KAKENHI-PROJECT-21229011
[Presentation] Cell cycle dysregulation in spinal and bulbar muscular atrophy (SBMA).2011
- Author(s)
  Katsuno M, Adachi H, Kondo N, Minamiyama M, Doi H, Matsumoto S-J, Miyazaki Y, Tanaka F, Sobue G.
- Organizer
  Gordon conference on CAG triplet repeat disorders
- Place of Presentation
  Il Ciocco, Italy,
- Data Source
  KAKENHI-PROJECT-21229011
[Presentation] Cell cycle dysregulation in spinal and bulbar muscular atrophy (SBMA).2011
- Author(s)
  Katsuno M, Adachi H, Minamiyama M, Kondo N, Doi H, Matsumoto S, Miyazaki Y, Tanaka F, Sobue G.
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  パシフィコ横浜（神奈川）
- Data Source
  KAKENHI-PROJECT-21229011
[Presentation] Assembly and diversity of eukaryotic proteasomes2011
- Author(s)
  K. Tanaka
- Organizer
  The 7th General Meeting of the International Proteolysis Society (IPS) Hilton San Diego Resort and Spa
- Place of Presentation
  San Diego (USA)
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] In-depth study of structure and functions of eukaryotic proteasomes2011
- Author(s)
  K. Tanaka
- Organizer
  The 3rd Asia Pacific Protein Association (APPA) Conference
- Place of Presentation
  Shanghai University, Shanghai (China)
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] In-depth Study of Structure and Functions of Eukaryotic Proteasomes2011
- Author(s)
  Keiji Tanaka
- Organizer
  The 3^<rd> Asia Pacific Protein Association (APPA) Conference
- Place of Presentation
  Shanghai University, Shanghai, China(招待講演)
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] Central motor conduction time (CMCT) in patients with spinal and bulbar muscular atrophy (SBMA).2011
- Author(s)
  Suzuki K, Katsuno M, Banno H, Suga N, Hashizume A, Hara T, Hama T, Nakamura T, Hirayama M, Tanaka F, Sobue G.
- Organizer
  15th Congress of the European Federation of Neurological Societies
- Place of Presentation
  Budapest, Hungary
- Data Source
  KAKENHI-PROJECT-21229011
[Presentation] プロテアソームを基軸としたタンパク質分解研究2011
- Author(s)
  田中啓二
- Organizer
  先端医療センターMonthly Lecture
- Place of Presentation
  財団法人先端医療振興財団、神戸(招待講演)
- Year and Date
  2011-11-18
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] Molecular pathology of SBMA (Spinal Bulbar Muscular Atrophy) related gene CGRP1.2011
- Author(s)
  Minamiyama M, Katsuno M, Adachi H, Doi H, Kondo N, Tanaka F, Sobue G, Kurihara H.
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  パシフィコ横浜（神奈川）
- Data Source
  KAKENHI-PROJECT-21229011
[Presentation] プロテアソームを基軸とした細胞内リサイクルシステム2011
- Author(s)
  田中啓二
- Organizer
  日本DNA多型学会第20回学術集会
- Place of Presentation
  はまぎんホールヴァイマーレ、横浜(招待講演)
- Year and Date
  2011-11-18
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] 細胞内リサイクルシステム-新陳代謝の科学-2011
- Author(s)
  田中啓二
- Organizer
  第5回炎症・脂質代謝・メタボリサーチフォーラム
- Place of Presentation
  東京大学医学部教育研究棟、東京(招待講演)
- Year and Date
  2011-02-12
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] 球脊髄性筋萎縮症(SBMA)病態関連遺伝子CGRP1の分子機構2011
- Author(s)
  南山　誠, 勝野雅央, 足立弘明, 土井英樹, 近藤直英, 田中章景, 祖父江元, 栗原裕基.
- Organizer
  第52回日本神経学会学術大会
- Place of Presentation
  名古屋国際会議場（愛知）
- Data Source
  KAKENHI-PROJECT-21229011
[Presentation] In-depth Analysis of Proteasomal Assembly and Diversity in Eukaryotes2011
- Author(s)
  Keiji Tanaka
- Organizer
  International GMB Symposium "Molecular Life Science 2011" by GMB (The German Society for Biochemistry and Molecular Biology)
- Place of Presentation
  Goethe-University, Frankfurtam Main, Germany(招待講演)
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] 細胞内タンパク質分解系の病態生理学研究2011
- Author(s)
  田中啓二
- Organizer
  第84回日本内分泌学会学術総会内分泌代謝学の多領域との融合と新たな展開"マイスター賞受賞講演"
- Place of Presentation
  神戸国際会議場、神戸(招待講演)
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] プロテアソームの生物学～免疫型酵素の発見と分子免疫学への貢献～2011
- Author(s)
  田中啓二
- Organizer
  第61回日本アレルギー学会秋季学術大会
- Place of Presentation
  グランドプリンスホテ新高輪国際館パミール、東京(招待講演)
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] ユビキチン・プロテアソームシステムによるタンパク質分解2011
- Author(s)
  田中啓二
- Organizer
  京都産業大学・総合生命科学部開設記念シンポジウム"タンパク質の一生と生命システム」
- Place of Presentation
  京都(招待講演)
- Year and Date
  2011-03-10
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] 球脊髄性筋萎縮症における細胞周期異常.2011
- Author(s)
  勝野雅央, 足立弘明, 南山　誠, 土井英樹, 近藤直英, 松本慎二郎, 宮崎　雄, 坂野晴彦, 鈴木啓介, 田中章景, 祖父江元.
- Organizer
  第52回日本神経学会学術大会
- Place of Presentation
  名古屋国際会議場（愛知）
- Data Source
  KAKENHI-PROJECT-21229011
[Presentation] Assembly and Diversity of Eukaryotic Proteasomes2011
- Author(s)
  Keiji Tanaka
- Organizer
  The 7^<th> General Meeting of the International Proteolysis Society (IPS)
- Place of Presentation
  Hilton San Diego Resort and Spa., San Diego, USA(招待講演)
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] In-depth analysis of proteasomal assembly and diversity in eukaryotes2011
- Author(s)
  K. Tanaka
- Organizer
  International GMB Symposium "Molecular Life Science 2011" by GMB (The German Society for Biochemistry and Molecular Biology) Goethe-University, Frankfurt am Main
- Place of Presentation
  Germany
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] A peony extract enhances protein degradation systems and exerts therapeutic effects in the polyglutamine-mediated motor neuron disease2011
- Author(s)
  Adachi H, Tohnai G, Katsuno M, Minamiyama M, Doi H, Matsumoto S, Kondo N, Miyazaki Y, Tanaka F, Ohtsuka K, Sobue G
- Organizer
  Neuroscience 2011
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-21229011
[Presentation] Heat shock factor-1(Hsf-1) influences distribution of pathogenic androgen receptor aggregations in model mouse of spinal and bulbar muscular atrophy (SBMA)2011
- Author(s)
  Kondo N, Katsuno M, Adachi H, Minamiyama M, Doi H, Matsumoto S-J, Miyazaki Y, Tanaka F, Sobue G
- Organizer
  Gordon conference on CAG triplet repeat disorders
- Place of Presentation
  Il Ciocco, Italy
- Data Source
  KAKENHI-PROJECT-21229011
[Presentation] プロテアソームの多様性による免疫システム制御2011
- Author(s)
  田中啓二
- Organizer
  第7回骨免疫ワークショップ
- Place of Presentation
  パークハイアットホテル東京、東京(招待講演)
- Year and Date
  2011-11-25
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] 私のプロテアソーム研究～分子から個体レベルまで～2011
- Author(s)
  田中啓二
- Organizer
  日本蛋白質科学会創立10周年記念シンポジウム
- Place of Presentation
  大阪大学・銀杏会館大阪、大阪(招待講演)
- Year and Date
  2011-06-06
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] Up-to-date Study of Eukaryotic Proteasomes2011
- Author(s)
  Keiji Tanaka
- Organizer
  The 2^<nd> Japan-Sino Autophagy Symposium
- Place of Presentation
  Shonan Village Center, Kanagawa, Japan(招待講演)
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] Parkinson's disease : a quality control disease of depolaized mitochondoria.2011
- Author(s)
  Keiji Tanaka
- Organizer
  The 1^<st> small Korea/Japan symposium
- Place of Presentation
  Seoul, Korea(招待講演)
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] プロテアソームとオートファジーの生理と病態.細胞・脳機能研究の融合による神経疾患診断・治療法開発拠点の形成2011
- Author(s)
  田中啓二
- Organizer
  第1回公開シンポジウム
- Place of Presentation
  順天堂大学、東京(招待講演)
- Year and Date
  2011-10-13
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] 球脊髄性筋萎縮症モデルマウスにおける異常蛋白凝集の病理学的分布はHsf-1の影響を受ける.2011
- Author(s)
  近藤直英, 勝野雅央, 足立弘明, 南山誠, 土井英樹, 松本慎二郎, 宮崎雄, 飯田円, 田中章景, 祖父江元.
- Organizer
  第52回日本神経学会学術大会
- Place of Presentation
  名古屋国際会議場（愛知）
- Data Source
  KAKENHI-PROJECT-21229011
[Presentation] Heat shock factor-1 (Hsf-1) influences distribution of pathogenic androgen receptor aggregations in model mouse of spinal and bulbar muscular atrophy (SBMA).2011
- Author(s)
  Kondo N, Katsuno M, Adachi H, Minamiyama M, Doi H, Matsumoto S-J, Miyazaki Y, Tanaka F, Sobue G.
- Organizer
  Gordon conference on CAG triplet repeat disorders
- Place of Presentation
  Il Ciocco, Italy,
- Data Source
  KAKENHI-PROJECT-21229011
[Presentation] オートファジー"加齢、酸化ストレス応答と肝細胞がん"2011
- Author(s)
  田中啓二
- Organizer
  第11回日本抗加齢医学会総会:アンチエイジングの心の眼を拓く:ベーシックサイエンス企画シンポジウム1「抗酸化環境応答と加齢」
- Place of Presentation
  国立京都国際会館、京都(招待講演)
- Year and Date
  2011-05-27
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] プロテアソームとオートファジー～病態生理学の最新研究～2011
- Author(s)
  田中啓二
- Organizer
  第25回モロシヌス研究会
- Place of Presentation
  当間高原リゾート・ベルナティオ(新潟県十日町)、新潟(招待講演)
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] Cell cycle dysregulation in spinal and bulbar muscular atrophy (SBMA)2011
- Author(s)
  Katsuno M, Adachi H, Kondo N, Minamiyama M, Doi H, Matsumoto S-J, Miyazaki Y, Tanaka F, Sobue G
- Organizer
  Gordon conference on CAG triplet repeat disorders
- Place of Presentation
  Il Ciocco, Italy
- Data Source
  KAKENHI-PROJECT-21229011
[Presentation] A peony extract alleviates polyglutamine-mediated motor neuron disease2010
- Author(s)
  Adachi H, Tohnai G, Katsuno M, Minamiyama M, Doi H, Matsumoto S, Kondo N, Miyazaki Y, Tanaka F, Sobue G.
- Organizer
  Neuroscience 2010
- Place of Presentation
  San Diego, USA
- Year and Date
  2010-11-16
- Data Source
  KAKENHI-PROJECT-21229011
[Presentation] Autophagy and Parkinson's Disease2010
- Author(s)
  Keiji Tanaka
- Organizer
  1^<st> Sino-Japan Autophagy Symposium
- Place of Presentation
  Xi'an, China(招待講演)
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] 細胞内リサイクルシステム-新陳代謝と健康-2010
- Author(s)
  田中啓二
- Organizer
  徳島大学市民公開講演会～生命の謎に迫る～
- Place of Presentation
  長井記念ホール、徳島(招待講演)
- Year and Date
  2010-07-31
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] The Role of the PINK1/Parkin Pathway on the Autophagic Clearance of Damaged Mitochondria2010
- Author(s)
  Keiji Tanaka
- Organizer
  The 2010 Rappaport Research Institute Ubiquitin Day
- Place of Presentation
  Cancer Center, Rappaport Research Institute and Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel(招待講演)
- Year and Date
  2010-03-11
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] Immunological roles of the thymoproteasome2010
- Author(s)
  K. Tanaka
- Organizer
  "Biology of the Ubiquitin and the Ubiquitin-Like Systems"
- Place of Presentation
  Jerusalem (Israel)
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] Autophagic Control of Mitochondrial Homeostasis and Neurodegeneration" [Mechanism underling the cause of Parkinson's Disease : The functions of Parkin/PINK1]2010
- Author(s)
  Keiji Tanaka
- Organizer
  Proteolysis and Neurodegeneration : 5th INPROTEOLYSIS meeting, EMBO Workshop
- Place of Presentation
  Madrid, Spain(招待講演)
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] Immunological Roles of the Thymoproteasome.2010
- Author(s)
  Keiji Tanaka
- Organizer
  Biology of the Ubiquitin and the Ubiquitin-Like Systems
- Place of Presentation
  Jerusalem, Israel(招待講演)
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] Impairment of proteolytic homeostasis as cause of neurodegeneration"in S1 JOINT SYMPOSIUM2010
- Author(s)
  K. Tanaka
- Organizer
  PRION & ICN Congress
- Place of Presentation
  Salzburg (Austria)
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] 蛋白質リサイクルシステムの意義とその破綻による疾病2010
- Author(s)
  田中啓二
- Organizer
  科学技術政策研究所シンポジウム:近未来への招待状～ナイスステップな研究者2009からのメッセージ～
- Place of Presentation
  文部科学省第2講堂、東京(招待講演)
- Year and Date
  2010-04-22
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] 細胞内リサイクルシステム-新陳代謝の科学-2010
- Author(s)
  田中啓二
- Organizer
  JSTさきがけ「代謝と機能制御」領域研究報告会シンポジウム:特別講演
- Place of Presentation
  東京大学弥生講堂・一條ホール、東京(招待講演)
- Year and Date
  2010-12-13
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] The Structure and Biological Functions of Proteasomes (+The Role of PINK1/Parkin in Mitophagy and Parkinson's Disease).2010
- Author(s)
  田中啓二
- Organizer
  第62回日本細胞生物学会大会 (The 62nd Annual Meeting of the Japanese Society of Cell Biology)・特別講演
- Place of Presentation
  Osaka(招待講演)
- Year and Date
  2010-05-20
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] Overview of My Proteasome Study, focusing on the Structure and Functions.2010
- Author(s)
  Keiji Tanaka
- Organizer
  International Conference on Radiation and Cancer Biology
- Place of Presentation
  Nagasaki, Japan(招待講演)
- Year and Date
  2010-01-17
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] Impairment of proteolytic homeostasis as cause of neurodegeneration2010
- Author(s)
  Keiji Tanaka
- Organizer
  S1 JOINT SYMPOSIUM [Key Mechanisms in Neurodegeneration] PRION & ICN Congress
- Place of Presentation
  Salzburg, Austria(招待講演)
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] In-depth Analysis of Structure and Functions of Eukaryotic Proteasomes2010
- Author(s)
  Keiji Tanaka
- Organizer
  "Global COE" Integrative Life Science" Meeting, Based on the Study of Biosignaling Mechanisms
- Place of Presentation
  The University of Tokyo, Japan(招待講演)
- Year and Date
  2010-03-05
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] The PINK1/Parkin pathway controls mitochondrial homeostasis whose impairment causes Parkinson's disease.2010
- Author(s)
  Keiji Tanaka
- Organizer
  Global COE International Symposium/Retreat 2010
- Place of Presentation
  Awaji Island, Japan(招待講演)
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] In Depth Analysis of protein Degradation in the Life Science Field.2010
- Author(s)
  田中啓二
- Organizer
  69^<th> Annual Meeting of The Japanese Cancer Association "Conquering Cancer and Collective Wisdom
- Place of Presentation
  大阪(招待講演)
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] Role of Proteolysis in Liver Pathophysiology.2010
- Author(s)
  Keiji Tanaka
- Organizer
  The 9^<th> JSH Single Topic Conference "NASH 2010"
- Place of Presentation
  Tokyo, Japan(招待講演)
- Year and Date
  2010-11-19
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] 私のプロテアソーム研究-免疫との予期しなかった遭遇-2010
- Author(s)
  田中啓二
- Organizer
  千葉大学G-COEプログラム"免疫システム統御治療学"免疫学リトリート
- Place of Presentation
  千葉生命の森リゾート、千葉(招待講演)
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] プロテアソーム:オーバービューと免疫研究の最前線2010
- Author(s)
  田中啓二
- Organizer
  第54回日本リウマチ学会総会・学術集会:特別講演
- Place of Presentation
  神戸(招待講演)
- Year and Date
  2010-04-23
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] パーキンソン病の分子病態機序のブレイクススルー:Parkin/PINK1の機能"パーキンソン病の分子病態機序2010
- Author(s)
  田中啓二、松田憲之、尾勝圭
- Organizer
  新世代の神経学-Breakthrough to the NEXT STAGE-、第51回日本神経学会総会
- Place of Presentation
  東京(招待講演)
- Year and Date
  2010-05-22
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] Assembly of Eukaryotic Proteasomes assisted by Molecular Chaperones"2010
- Author(s)
  Keiji Tanaka
- Organizer
  The 3^<rd> International Symposium on Protein Community
- Place of Presentation
  Hotel Nikko Nara, Nara, Japan(招待講演)
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] Disrupted TGF-beta signaling in spinal and bulbar muscular atrophy.2010
- Author(s)
  Katsuno M, Adachi H, Minamiyama M, Doi H, Kondo N, Matsumoto S, Miyazaki Y, Banno H, Suzuki K, Tanaka F, Sobue G.
- Organizer
  21st International Symposium on ALS/MND.
- Place of Presentation
  Orlando, USA
- Year and Date
  2010-12-12
- Data Source
  KAKENHI-PROJECT-21229011
[Presentation] 私の履歴書 -プロテアソームを基軸としたタンパク質分解研究-2010
- Author(s)
  田中啓二
- Organizer
  第15回病態プロテアーゼ学会学術集会"『日本学士院賞』受賞記念講演
- Place of Presentation
  千里ライフサイエンスセンター、大阪(招待講演)
- Year and Date
  2010-08-20
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] Autophagic Control of Mitochondrial Homeostasis and Neurodegeneration2010
- Author(s)
  K. Tanaka
- Organizer
  "Proteolysis and Neurodegeneration : 5th INPROTEOLYSIS meeting", EMBO Workshop
- Place of Presentation
  Madrid (Spain)
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] オートファジーと神経変性疾患2009
- Author(s)
  田中啓二
- Organizer
  第1回ニューロフォーラム東京
- Place of Presentation
  京王プラザホテル、東京(招待講演)
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] 細胞内大規模タンパク質分解システムの作動機構と生理機構2009
- Author(s)
  田中啓二
- Organizer
  日本分子生物学会第9回春期シンポジウム(090511-12)分子生物学の新たな胎動～宮崎から黎明の曙光～
- Place of Presentation
  宮崎(招待講演)
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] 細胞内リサイクルシステム.回想と論文執筆奮戦記2009
- Author(s)
  田中啓二
- Organizer
  筑波大学医科学セミナー
- Place of Presentation
  筑波(招待講演)
- Year and Date
  2009-12-18
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] トップジャーナルの目指し方～私の経験から～2009
- Author(s)
  田中啓二
- Organizer
  精神研特別企画セミナー
- Place of Presentation
  東京(招待講演)
- Year and Date
  2009-12-17
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] TDP-43 depletion induces neuronal cell damage through dysregulation of Rho family GTPases2009
- Author(s)
  Iguchi Y, Katsuno M, Niwa J, Yamada S, Sone J, Waza M, Adachi H, Tanaka F, Nagata K, Arimura N, Watanabe T, Kaibuchi K, Sobue G.
- Organizer
  Neuroscience 2009
- Place of Presentation
  Chicago, USA
- Year and Date
  2009-10-17
- Data Source
  KAKENHI-PROJECT-21229011
[Presentation] プロテアソームを基軸としたタンパク質分解系の先駆的研究2009
- Author(s)
  田中啓二
- Organizer
  2009年度「武田医学賞」受賞講演
- Place of Presentation
  ホテルオークラ、東京(招待講演)
- Year and Date
  2009-11-13
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] Molecular Assembly and Diversity of Proteasomes2009
- Author(s)
  Keiji Tanaka
- Organizer
  Ubiquitin, Ubiquitin-like Proteins and Proteasomes : Functions and Dysfunctions, Inserm Workshop
- Place of Presentation
  Saint-Raphael, France(招待講演)
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] Molecular Assembly and Diversity of Eukaryotic Proteasomes.2009
- Author(s)
  Keiji Tanaka
- Organizer
  EMBO CONFERENCE on "Ubiquitin and Ubiqutin-like Modifiers in Health and Disease"
- Place of Presentation
  Riva Del Garda, Italy(招待講演)
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] 細胞内タンパク質の動態と生命科学2009
- Author(s)
  田中啓二
- Organizer
  第63回日本栄養・食糧学会大会特別講演
- Place of Presentation
  長崎(招待講演)
- Year and Date
  2009-05-22
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] Molecular Mechanisms of Chaperone-assisted Proteasome Assembly.2009
- Author(s)
  Keiji Tanaka
- Organizer
  The 4th International Congress on Stress Responses in Biology and Medicine. The 4th Annual Meeting of The Biomedical Society for Stress Response
- Place of Presentation
  Sapporo, Japan(招待講演)
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] Molecular Assembly and Diversity of Eukaryotic Proteasomes.2009
- Author(s)
  Keiji Tanaka
- Organizer
  Proteolysis Research : Succession and Development
- Place of Presentation
  Tokyo Garden Palace, Tokyo, Japan(招待講演)
- Year and Date
  2009-07-05
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] Phase 2 trial of leuprorelin in patients with spinal and bulbar muscular atrophy2009
- Author(s)
  Banno H, Katsuno M, Suzuki K, Takeuchi Y, Kawashima M, Suga N, Takamori M, Ito M, Nakamura T, Matsuo K, Yamada S, Oki Y, Adachi H, Minamiyama M, Waza M, Atsuta N, Watanabe H, Fujimoto Y, Nakashima T, Tanaka F, Doyu M, Sobue G.
- Organizer
  61th American Academy of Neurology Annual Meeting
- Place of Presentation
  Seattle, USA
- Year and Date
  2009-04-26
- Data Source
  KAKENHI-PROJECT-21229011
[Presentation] Molecular assembly and diversity of proteasomes2009
- Author(s)
  K. Tanaka
- Organizer
  Ubiquitin, Ubiquitin-like Proteins and Proteasomes : Functions and Dysfunctions, Inserm Workshop
- Place of Presentation
  Saint-Raphael, (France)
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] プロテアソーム研究の過去・現在・未来"予期しなかった免疫との出会い"2008
- Author(s)
  田中啓二
- Organizer
  免疫サマースクール2008-免疫まるかじり
- Place of Presentation
  南淡路ロイヤルホテル(淡路)
- Year and Date
  2008-08-24
- Data Source
  KAKENHI-PROJECT-17002019
[Presentation] Unexpected encounter with immunity during my proteasome study2008
- Author(s)
  Keiji Tanaka
- Organizer
  Japan-German Immunology Seminar 2008 : Immune Regulation in Health and Disease
- Place of Presentation
  Fukuoka, Japan
- Data Source
  KAKENHI-PROJECT-17002019
[Presentation] The Novel Thymoproteasome Regulates Development of CD8^+ T Cells.2008
- Author(s)
  Keiji Tanaka
- Organizer
  33^<rd> FEBS Congress & 11^<th> IUBMB Conference (Symposium on the ubiquitin-proteasome system)
- Place of Presentation
  Peace and Friendship Stadium, Athens, Greece
- Year and Date
  2008-06-30
- Data Source
  KAKENHI-PROJECT-17002019
[Presentation] Protein Degradation and Neuro-degenerative Diseases.2008
- Author(s)
  田中啓二
- Organizer
  Neuroscience 2008第31回日本神経科学大会. 特別講演。
- Place of Presentation
  東京フォーラム)東京.
- Year and Date
  2008-07-10
- Data Source
  KAKENHI-PROJECT-17002019
[Presentation] The Novel Thymoproteasome Regulates Development of CD8+ T Cells.2008
- Author(s)
  Keiji Tanaka
- Organizer
  33rd FEBS Congress & 11th IUBMB Conference(Symposium on the ubiquitin-proteasome system)Peace and Friendship Stadium
- Place of Presentation
  Athens, Greece.
- Year and Date
  2008-06-30
- Data Source
  KAKENHI-PROJECT-17002019
[Presentation] Protein Degradation and Neuro-degenerative Diseases.2008
- Author(s)
  田中啓二
- Organizer
  Neuroscience 2008 第31回日本神経科学大会.特別講演
- Place of Presentation
  (東京フォーラム)東京
- Year and Date
  2008-07-10
- Data Source
  KAKENHI-PROJECT-17002019
[Presentation] Molecular Assembly and Dicersity of Proteasomes.2008
- Author(s)
  Keiji Tanaka
- Organizer
  Max-Planck-Institute of Biochemistry
- Place of Presentation
  Martinsried, Germany
- Year and Date
  2008-07-02
- Data Source
  KAKENHI-PROJECT-17002019
[Presentation] Unexpected encounter with immunity during my proteasome study.2008
- Author(s)
  Keiji Tanaka
- Organizer
  Japan-German Immunology Seminar 2008:Immune Regulation in Health and Disease.
- Place of Presentation
  Fukuoka, Japan.
- Data Source
  KAKENHI-PROJECT-17002019
[Presentation] プロテアソームの分子集合機構の解明・どのように巨大で複雑な複合体は形成されるか?ターゲット蛋白研究プログラムシンポジウム(19年度文部科学省)2008
- Author(s)
  田中啓二
- Organizer
  東京国際フォーラム
- Place of Presentation
  東京
- Year and Date
  2008-02-12
- Data Source
  KAKENHI-PROJECT-17002019
[Presentation] Dciscovery of thymus-specific proteasomes"thymoproteasomes"that regulate the development of CDB+T cells2007
- Author(s)
  Keiji Tanaka., et. al.
- Organizer
  COE INTERNATIONAL SYMPOSIUM 2007
- Place of Presentation
  Inamori/Yamauchi Hall,Kyoto University Kyoto,Japan
- Data Source
  KAKENHI-PROJECT-17002019
[Presentation] プロテアソームの分子集合機構と分子多様性の解析2007
- Author(s)
  田中啓二
- Organizer
  九州大学生体防御研究所セミナー
- Place of Presentation
  福岡
- Year and Date
  2007-07-02
- Data Source
  KAKENHI-PROJECT-17002019
[Presentation] オートファジー(Self-eating)と神経変性疾患2007
- Author(s)
  田中啓二
- Organizer
  第5回京都神経科学セミナー
- Place of Presentation
  京都
- Year and Date
  2007-07-03
- Data Source
  KAKENHI-PROJECT-17002019
[Presentation] タンパク質の輪廻転生と生命科学2007
- Author(s)
  田中啓二
- Organizer
  東京大学医学部生化学・栄養学講義
- Place of Presentation
  東京
- Year and Date
  2007-10-29
- Data Source
  KAKENHI-PROJECT-17002019
[Presentation] オートファジーによる制御2007
- Author(s)
  田中啓二
- Organizer
  第2回臨床ストレス応答学会
- Place of Presentation
  東京
- Year and Date
  2007-12-01
- Data Source
  KAKENHI-PROJECT-17002019
[Presentation] 蛋白質の輪廻転生・プロテアソームとオートファジーの世界2007
- Author(s)
  田中啓二
- Organizer
  鹿児島大学生埋化学セミナー
- Place of Presentation
  鹿児島
- Year and Date
  2007-12-21
- Data Source
  KAKENHI-PROJECT-17002019
[Presentation] Pathophysiology of Consitutive Autophagy2007
- Author(s)
  Keiji Tanaka., et. al.
- Organizer
  The 20th Naito Conference/Innate Immunity in Medicine and Biology [III]
- Place of Presentation
  湘南国際村センター神奈川
- Data Source
  KAKENHI-PROJECT-17002019
[Presentation] 蛋白質の輪廻転生と生命科学2007
- Author(s)
  田中啓二
- Organizer
  京都大学医学部大学院講義
- Place of Presentation
  京都
- Year and Date
  2007-07-13
- Data Source
  KAKENHI-PROJECT-17002019
[Presentation] Regulation of Thymic Selection by the Thymus-specific Proteasome "Thymoproteasome"2007
- Author(s)
  Keiji Tanaka., et. al.
- Organizer
  EMBO CONFERENCE/Ubiquitin and Ubiqutin-like Modifiers in Cellular Regulation
- Place of Presentation
  Riva Del Garda,Italy
- Data Source
  KAKENHI-PROJECT-17002019
[Presentation] 私のプロテアソーム研究-黎明期から成長期を辿って-2007
- Author(s)
  田中啓二
- Organizer
  BMB2007マスターズレクチャー
- Place of Presentation
  東京
- Year and Date
  2007-12-12
- Data Source
  KAKENHI-PROJECT-17002019
[Presentation] ユニークな蛋白質分解システム・プロテアソームとオートファジー2007
- Author(s)
  田中啓二
- Organizer
  第11回Molecular Cardiovascular Conference
- Place of Presentation
  キロロ"ホテルピアノ"北海道余市郡赤井川村
- Data Source
  KAKENHI-PROJECT-17002019
[Presentation] Protein Quality Control by Constitutive Autophag2007
- Author(s)
  Keiji Tanaka., et. al.
- Organizer
  The Ubiquitin Family (CSHS Symposium):Quality Control
- Place of Presentation
  New York, USA
- Data Source
  KAKENHI-PROJECT-17002019
[Presentation] 蛋白質の輪廻転生と生命科学2007
- Author(s)
  田中啓二
- Organizer
  大阪大学微生物病研究所学術講演会
- Place of Presentation
  大阪
- Year and Date
  2007-02-07
- Data Source
  KAKENHI-PROJECT-17002019
[Presentation] タンパク質の輪廻転生と生命科学2007
- Author(s)
  田中啓二
- Organizer
  メディカルゲノム専攻「システム細胞情報論」平成19年度講義
- Place of Presentation
  医科研一号館・一階講堂東京
- Year and Date
  2007-05-11
- Data Source
  KAKENHI-PROJECT-17002019
[Presentation] Discovery of Thymoproteasomes-Implication for Thymic Selection2007
- Author(s)
  Keiji Tanaka
- Organizer
  2007 Korea-Japan Joint Symposium in Seoul
- Place of Presentation
  Seoul,Korea
- Year and Date
  2007-09-05
- Data Source
  KAKENHI-PROJECT-17002019
[Presentation] 蛋白質の輪廻転生と免疫2007
- Author(s)
  田中啓二
- Organizer
  九州大学医学部生命基礎医学免疫学各論講義
- Place of Presentation
  福岡
- Year and Date
  2007-07-02
- Data Source
  KAKENHI-PROJECT-17002019
[Presentation] 蛋白質の死を決定する分解装置、第27会日本医学会総会2007・シンポジウム2007
- Author(s)
  田中啓二
- Organizer
  蛋白質の死と病気"ユビキチン・プロテアソームとオートファジー"
- Place of Presentation
  大阪
- Year and Date
  2007-04-06
- Data Source
  KAKENHI-PROJECT-17002019
[Presentation] 蛋白質の輪廻転生と生命科学2007
- Author(s)
  田中啓二
- Organizer
  東京都神経科学総合研究所セミナー
- Place of Presentation
  東京
- Year and Date
  2007-07-12
- Data Source
  KAKENHI-PROJECT-17002019
[Presentation] タンパク質の品質管理と疾患そしてそのモデルマウス2007
- Author(s)
  田中啓二
- Organizer
  第54回日本実験動物学会総会シンポジウム疾患モデルマウス:系統樹立と表現型解析の新潮流
- Place of Presentation
  江戸川区民ホール・タワーホール船堀東京
- Year and Date
  2007-05-23
- Data Source
  KAKENHI-PROJECT-17002019
[Presentation] Discovery of Thymus-specific Proteasomes "Thymoproteasome" that regalate the Development of CD8^+ T Cells2007
- Author(s)
  Keiji Tanaka
- Organizer
  Intemational Symposium on Protein Modification and Degradafion in Beijing, SPMDB 2007
- Place of Presentation
  Beijing Friendship Hotel,Beijing,China
- Data Source
  KAKENHI-PROJECT-17002019
[Presentation] 蛋白質の輪廻転生と生命科学2007
- Author(s)
  田中啓二
- Organizer
  日本大学大学院医学研究科平成19年度講義
- Place of Presentation
  東京
- Year and Date
  2007-06-16
- Data Source
  KAKENHI-PROJECT-17002019
[Presentation] プロテアソームの発見から最新の動態解析まで
- Author(s)
  田中啓二
- Organizer
  文部科学省「理数学生育成支援事業」独創的発想に富む科学者育成プログラム「出る杭を伸ばすヘリックスプロヘクト」採択事業「七人の侍」による記念講演会「大学コンソーシャム秋田」
- Place of Presentation
  カレッジプラザ講堂秋田
- Invited
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] Ubiquitin Phosphorylation : a missing link between activation and recruitment of Parkin for mitophagy
- Author(s)
  Keiji Tanaka
- Organizer
  The 7th International Symposium on Autophagy
- Place of Presentation
  Huangshan, China
- Year and Date
  2015-03-19 – 2015-03-23
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] The Proteasome - From Molecular Mechanisms to Pathophysiological Roles -
- Author(s)
  Keiji Tanaka
- Organizer
  Scienticf Forum
- Place of Presentation
  Peking University Health Science Center & Main Campus Beijing, China
- Invited
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] PINK1（家族性パーキンソン病の責任遺伝子産物）によるミトコンドリアの品質管理機構.
- Author(s)
  田中啓二
- Organizer
  第85回日本生化学会大会シンポジウム（1S17）ミトコンドリアの動的な構造・機能変換とその生理機能
- Place of Presentation
  福岡
- Invited
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] The Proteasome- From Basic Mechanisms To Immunological Roles
- Author(s)
  Keiji Tanaka
- Organizer
  10th RCGN International Symposium of Academic Frontier“Genome Information and Cellular Systems - New Frontier of Medicine
- Place of Presentation
  Saitama Medical University Hidaka Campus Saitama
- Invited
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] オートファジーの破綻によるミトコンドリアストレスと肝癌・神経変性疾患
- Author(s)
  田中啓二
- Organizer
  第9回臨床ストレス応答学会大会特別講演
- Place of Presentation
  岡山大学鹿田キャンパス内マスカットキューブ、岡山県岡山市
- Year and Date
  2014-11-02 – 2014-11-03
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] 「プロテアソーム」動作原理から炎症・免疫疾患制御への展望
- Author(s)
  田中啓二
- Organizer
  第35回日本炎症・再生医学会Think Different教育講演
- Place of Presentation
  万国津梁館、沖縄県名護市
- Year and Date
  2014-07-01 – 2014-07-04
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] The Proteasome : Basic Mechanisms and The Immunological Roles
- Author(s)
  Keiji Tanaka
- Organizer
  CBSM2014-Yonsei BK21plus Joint symposium
- Place of Presentation
  Yonsei Univ. (Seoul) & Gunja Village(Andong), Korea
- Year and Date
  2014-06-19 – 2014-06-21
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] Discovery and Pathophysiology of Immuno-typed Proteasomes.
- Author(s)
  Keiji Tanaka
- Organizer
  Goldberg Lab Reunion and Symposium
- Place of Presentation
  Joseph B. Markin Conference Center Harvard Medical School, USA
- Invited
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] 未知への探究心　私のプロテアソーム研究から・・・
- Author(s)
  田中啓二
- Organizer
  第64回日本泌尿器科学会西日本総会　知・技・心　～求められる泌尿器科を目指して～
- Place of Presentation
  徳島県郷土文化会館あわぎんホール、徳島
- Invited
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] Pathophysiological Roles of the Proteasome in Vertebrate
- Author(s)
  Keiji Tanaka
- Organizer
  OPENING LECTURE The EUROMEDLAB Milano 2013 Congress
- Place of Presentation
  Milano Convention Center, Milano, Italy
- Invited
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] Proteasome Dynamics and Physiopathology focusing on Immunity
- Author(s)
  Keiji Tanaka
- Organizer
  ZOMES VIII Conference-From systems dynamics to biology
- Place of Presentation
  Xiamen Grand Hotel, Xiamen, China
- Year and Date
  2014-11-18 – 2014-11-21
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] 神経変性疾患のトランスレーショナルリサーチ
- Author(s)
  勝野雅央, 坂野晴彦, 鈴木啓介, 橋詰淳, 足立弘明, 田中章景, 祖父江元.
- Organizer
  第109回日本内科学会総会・講演会シンポジウム「わが国のトランスレーショナルリサーチとEBM」
- Place of Presentation
  みやこめっせ（京都）
- Invited
- Data Source
  KAKENHI-PROJECT-21229011
[Presentation] プロテアソームの基礎と生理病態学
- Author(s)
  田中啓二
- Organizer
  日本薬学会第133年回「薬科学の底力」
- Place of Presentation
  パシフィコ横浜、横浜
- Invited
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] The PINK1-Parkin system controls mitochondrial homeostasis whose collapse causes Parkinson’s disease.
- Author(s)
  Keiji Tanaka
- Organizer
  The 4th Korea-Japan Symposium
- Place of Presentation
  Seoul National University, Korea
- Invited
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] CREST「構造生命科学」H24年度　採択課題の紹介とプロテアソームの構造研究：プラットフォームの「支援」と「高度化」への期待
- Author(s)
  田中啓二
- Organizer
  創薬等支援技術基盤プラットフォーム第１回研究交流会
- Place of Presentation
  神戸ポートピアホテル　神戸
- Invited
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] 私のプロテアソーム研究を回想して
- Author(s)
  田中啓二
- Organizer
  第66回日本細胞生物学会 : 七人の侍たちからのメッセージ～私の仕事を通じて若者達に伝えたきこと～Mol Cell (preview)
- Place of Presentation
  奈良県新公会堂・東大寺総合文化センター、奈良県奈良市
- Year and Date
  2014-06-11 – 2014-06-13
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] ユビキチン化とは何か
- Author(s)
  田中啓二
- Organizer
  第76回日本生化学会中部支部例会・シンポジウム　「タンパク質の翻訳後修飾の役割」
- Place of Presentation
  自然科学研究機構岡崎コンファレンスセンター, 岡崎
- Invited
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] Surveillance of Mitochondrial Homeostasis by the PINK1-Parkin System
- Author(s)
  Keiji Tanaka
- Organizer
  EMBO Conference Ubiquitin & Ubiquitin-like Proteins : At the crossroads from chromatin to protein
- Place of Presentation
  Buenos Aires, Argentina
- Year and Date
  2014-10-19 – 2014-10-24
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] 新しい免疫学への期待　ー私の免疫研究を振り返ってー
- Author(s)
  田中啓二
- Organizer
  東京大学免疫学教室（高柳研）研究室オープン記念講演会
- Place of Presentation
  東京大学医学系研究科教育研究棟14階鉄門記念講堂、東京
- Invited
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] プロテアソーム（蛋白質分解酵素複合体）の動態と病態生理に関する研究動向
- Author(s)
  田中啓二
- Organizer
  第26回日本臨床内科医学会-いのちを支える地域医療の再生-　特別講演 II
- Place of Presentation
  ホテルクレメント徳島　　徳島
- Invited
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] Surveillance of Mitochondrial Homeostasis by the PINK1-Parkin System
- Author(s)
  Keiji Tanaka
- Organizer
  Post-GCOE Program/Grants for Excellent Graduate Schools Organelle Homeostasis Research Center: Kick-off Symposium
- Place of Presentation
  Audio-Visual Hall, Collaborative Research Station-I, Kyushu University
- Invited
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] プロテアソーム　～発見の糸口から病態生理研究に迫る～
- Author(s)
  田中啓二
- Organizer
  「先端研セミナー」
- Place of Presentation
  第一三共株式会社品川研究開発センター東京
- Invited
- Data Source
  KAKENHI-PROJECT-21000012
[Presentation] The PINK1-Parkin System Controls Mitochondrial Homeostasis to Suppress The Cause of Parkinson's Disease
- Author(s)
  Keiji Tanaka
- Organizer
  The KSU International Symposium on Cutting-Edge of Life Sciences
- Place of Presentation
  Musubiwaza-hall at Mibu Campus of KSU, Kyoto
- Year and Date
  2014-05-30 – 2014-05-31
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] The PINK1-Parkin Pathway Controls Mitochondrial Homeostasis Whose Collapse Causes Parkinson's Disease
- Author(s)
  Keiji Tanaka
- Organizer
  International Conference on Protein Metabolism and Diseases
- Place of Presentation
  SolBeach Hotel & Resort, Yangyang, Korea
- Year and Date
  2014-07-09 – 2014-07-11
- Invited
- Data Source
  KAKENHI-PROJECT-26000014
[Presentation] プロテオゲノミクス研究　～私の研究から～　ヒトプロテオゲノミクスの現状とロードマップによる推進「エピゲノムとプロテオームの統合によるヒトの生命と病気の解明」
- Author(s)
  田中啓二
- Organizer
  学術研究プロジェクトシンポジウム
- Place of Presentation
  日本学術会議講堂、東京
- Invited
- Data Source
  KAKENHI-PROJECT-21000012
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tanaka keiji 田中 啓二

TANAKA Keiji 田中 啓二

Research Projects

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プロテアソーム：相分離とユビキチンが拓く生理病態学Principal Investigator

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Cell Biology of ProteasomesPrincipal Investigator

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リン酸化ユビキチンを手がかりにマイトファジーの全貌にせまるPrincipal Investigator

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The Proteasome: Mechanistic Actions and In-depth Physiopathological AnalysesPrincipal Investigator

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In-depth Analysis of Proteasome-Mediated Regulatory ProteolysisPrincipal Investigator

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Analyses of Molecular Assembly and Diversity of ProteasomesPrincipal Investigator

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Studies on proteolysis mediated by the proteasomes and ubiquitinPrincipal Investigator

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プロテアソームによる細胞周期と免疫始動制御Principal Investigator

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tanaka keiji 田中啓二

TANAKA Keiji 田中啓二