MIZUNO Yoshikuni 水野美邦

… Alternative Names

Researcher Number	30049043
External Links
Affiliation (based on the past Project Information) *help	2006 – 2007: 順天堂大学, 大学院・医学研究科, 特任教授 2006: Juntendo university, Neurology, Professer, 大学院医学研究科, 特任教授 1988 – 2006: 順天堂大学, 医学部, 教授 2000 – 2001: 順天堂大学, 医学部・脳神経内科, 教授 1991: 順天堂大学, 医学部・神経学講座, 教授
Review Section/Research Field	Principal Investigator Neurochemistry/Neuropharmacology / Biological Sciences / Neuroscience in general / Neurology Except Principal Investigator Neurology / Neurology / Biological Sciences / 広領域
Keywords	Principal Investigator パーキンソン病 / 神経細胞死 / ミトコンドリア / 発症機序 / MPTP / 環境因子 / 家族性パーキンソン病 / PINK1 / LRRK2 / Parkinson's disease … More Except Principal Investigator パーキンソン病 / 神経細胞死 / 家族性パーキンソン病 / 遺伝子治療 / MPTP / Parkinson's disease / Gene therapy / ハンチントン病 / アポトーシス / アデノ随伴ウイルスベクター / PARK6 / AAV vector / Apoptosis / Familial Parkinson's disease / ユビキチン / AR-JP / タウ / 進行性核上性麻痺 / PARK2 / Tau / Parkin / パーキン / パーキン遺伝子 / PINK1遺伝子 / DJ-1遺伝子 / 14-3-3η / PINK1 / DJ-1 / parkin gene / PINK1 gene / DJ-1 gene / PARK7 / 遺伝子工学 / パ-キンソン病 / 虚血性神経細胞死 / プロテアソーム / Apaf-1 / レトロウイルス / 神経幹細胞 / 移植 / 再生医療 / Bcl-2 / Bcl-xL / α-シヌクレイン / α-Synuclein / ARJP / Substantia nigra / Striatum / Adeno-associated virus / 神経栄養因子 / Ubiquitin-protein ligase / Ubiquitin-proteasome pathway / Lewy body / UbcH7 / ユビキチン・プロテアソーム系 / 若年性パーキンソン病 / CDCrel-1 / 脳梗塞 / Cerebral infarction / 猿 / Apaf-1-DN / alpha-synuclein / parkin遺伝子 / ドパミンキノン体 / Knock-down parkin / 運動系 / 脳 / 遺伝子 / ミトコンドリア / 脳移植 / 神経難病 / テトラヒドロイソキノリン / フリ-ラディアル / 興奮性アミノ酸 / 遺伝子解析 / 遺伝子解折 / neuronal death / Machado-Joseph病 / DRPLA / hereditary progressive dystonia / parkinson病 / energy crisis / mitochondria / Machado Josseph病 / 歯状核・赤核・淡蒼球・ルイ体萎縮 / 三塩基リピート / ミトコンドリア点変異 / ミトンドリア欠失 / エネルギークライシス / 外因・内因説 / テトラハイドロイソキノリン(TIQ) / 1-メチル-TIQ / ミトコンドリアDNAの欠失 / ミトコンドリアDNAの点変異 / 第四染色体 / パーキンソン病発症物質 / TIQ / β-カルボリニウムイオン / 発症物質 / 抗パーキンソン病薬 / ドーパミントランスポーター / パーキンソン病診断 / Mn-SOD / RLNG finger motif / ユビキチン様ドメイン / 蛋白質分解 / オートファジー / モディファイアー蛋白 / リソソーム / 蛋白分解 / モディファイアー蛋白質 / 基質蛋白質の選別 / ホームページ / caspase-1 / dominant negative / CuSOD / MnSOD / calbindin / FTDP-17 / 皮質基底核変性症 / L266V / P301L変異 / ハプロタイプ / 家族性パーキンソニズム / 皮膚幹細胞 / ガレクチン / Mashi-1 / 皮膚 / ウイルスベクター / リン酸化アルファ・シヌクレイン / リボザイム / 片側パーキンソン病モデル猿 / アルファ・シヌクレイン / パーキンソン病モデル猿 / ミトコンドリア呼吸酵素 / FDG脳代謝 / ノルアドレナリン / 情報処理過程 / bcl-xL / 神経変性疾患 / Parkinson disease / Neuronal cell death / 遺伝的背景 / 遺伝子型 / MJD1 / 遺伝子多型 / Genetic Background / PSP / Genotype / 常染色体劣性遺伝若年性パーキンソン病 / Parkin gene / Pigment epitheliom-derived fador / Neurotrophic fador / PEDF / 黒質神経細胞死 / レトロウィルスベクター / アストロサイト / マイクログリア / 黒質神経細胞 / Pigment epitheliurm-derived factori / Neurotrophic factor / Young onset Parkinson's disease / RING finger motif / Young onset Parkinson7s disease / 脳死判定 / 独立成分解析 / 脳波 / 信号処理 / カオス / 時系列解析 / brain death / independent component analysis / EEG / signal processing / chaos / time series analysis / ユビキチンリガーゼ / パーキン蛋白 / 基質 / パエル受容体 / 糖化修飾α-シヌクレイン / parkin / ubiquitin ligase / Pael receotor / ER stress / ubiquitin-proteasome系 / 糖化修飾アルファシヌクレイン / Lewy小体 / Ubiquitin ligase / Parkin protein / Ubiquitin-proteasome system / Juvenile Parkinson's disease / substrate / Pael receptor / o-glycosylatedα-synuclein / タウ蛋白 / 痴呆 / パーキンソニズム / 大脳皮質基底核変性症 / タウ遺伝子 / タウアイソフォーム / 髄液 / 遺伝子変異 / タウオパチー / 定量的RT-PCR法 / 前頭側頭型痴呆 / mRNA / RT-PCR / Tau protein / Dementia / Parkinsonism / Progressive supranuclear palsy / Corticobasal degeneration / Tau gene / Tau isoform / CSF / 酸化的ストレス / 骨髄移植 / ミクログリア / アデノウイルスベクター / GAPDH / Ischemic neuronal death / Oxidative stress / Adeno-associated virus vector / Bone marrow transplantation / Microglia / caspase 11 / Apaf-DN / α-synuclein / 大型動物(猿) / Caspase 11 / リガーゼ活性 / PDCD-2 / LMO-4 / Glup / ドーパ・ドパミンキノン / 発症機序 / ドパミン自動酸化 / ドパミンキノン / dopainine quinone / ligase activities / PARD7 / 連鎖解析 / 肝細胞増殖因子 / レトロウイルスベクター / 幹細胞 / HGF / MTPT / Regeneration medicine / Hepatocyte growth factor / Neuronal stem cell / Retrovirus vector / 遺伝性パーキンソン病 / 24-kDaサブユニット / ミトコンドリア機能低下 / ノックアウトマウス / 24-Daサブユニット / duplication / アグリゾーム / LRRK2 / ubiquitin-proteasome / 24-kDa subunit / mitochondrial dysfunction / Knock-out mice / RNA編集 / 変異ユビキチン / 脳保護療法 / RNA editing / Mutant ubiquitin / Proteasome / Neuronal death / Neuroprotection Less

パーキンソン病における神経細胞死の機序解明とその防御Principal Investigator
- Principal Investigator
  
  水野美邦
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Juntendo University
パーキンソン病におけるリン酸化アルファ・シヌクレイン制御薬剤の開発
- Principal Investigator
  
  望月秀樹
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Juntendo University
The analysis of Familial Parkinson's disease gene products and the research for identification of a novel Familial Parkinson's disease gene
- Principal Investigator
  
  HATTORI Nobutaka
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  JUNTENDO UNIVERSITY
PINK1 gene and DJ-1 gene mutation analysis about juvenile Parkinson's disease.
- Principal Investigator
  
  SATO Kenichi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Juntendo University
New therapy for cerebral infarction targeting of the control of mutant ubiquitin 1 (UBB+1) producted by RNA editing
- Principal Investigator
  
  URABE Takao
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Juntendo University
Enhancement of adult neurogenesis for Parkisnon's diseased primate models
- Principal Investigator
  
  MOCHIZUKI Hideki
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Juntendo University
自己皮膚幹細胞を用いたパーキンソン病治療
- Principal Investigator
  
  望月秀樹
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Juntendo University
Mutational and functional analysis for Familial Parkinson's disease
- Principal Investigator
  
  HATTORI Nobutaka
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  JUNTENDO UNIVERSITY
Linkage analysis for novel gene cause of familial Parkinson's disease
- Principal Investigator
  
  SATO Kenichi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  JUNTENDO UNIVERSITY
Primate Study for Gene Therapy of Porkinson's disease for clinic
- Principal Investigator
  
  MOCHIZUKI Hideki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Juntendo University
パーキンソン病の遺伝的背景の解析
- Principal Investigator
  
  小林智則
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Juntendo University
MUTATIONAL ANALYSIS OF THE PARKIN GENE AND FUNCTIONAL ANALYSIS OF THE PARKIN PROTEINPrincipal Investigator
- Principal Investigator
  
  MIZUNO Yoshikuni
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  JUNTENDO UNIVERSITY
Mutation and functional analysis of parkin responsible for AR-JP
- Principal Investigator
  
  HATTORI Nobutaka
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Juntendo University
Investigation of mechanism of tauopathy and application for clinical diagnosis
- Principal Investigator
  
  MORI Hideo
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Juntendo University
Basic research of the new gene therapy for cerebral infarction
- Principal Investigator
  
  URABE takao
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Juntendo University
蛋白質分解-新しいモディフアイアー蛋白質による制御
- Principal Investigator
  
  木南英紀
- Project Period (FY)
  2000 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Juntendo University
パーキンソン病に対する抗アポトーシス遺伝子を用いた新たな遺伝子治療
- Principal Investigator
  
  MOCHIZUKI Hideki
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Juntendo University
ICA analysis of EEG forjudgment of brain death
- Principal Investigator
  
  HORI Gen
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  広領域
- Research Institution
  RIKEN
パーキンソン病におけるユビキチン様蛋白質の意義
- Principal Investigator
  
  服部信孝
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Juntendo University
Reseach for Gene therapy of ARJP
- Principal Investigator
  
  MOCHIZUKI Hideki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Neurology
- Research Institution
  JUNTENDO UNIVERSITY
Inhibition of neuronal cell death in Parkinson's disease by transduction of neurotrophic factor gene.
- Principal Investigator
  
  MORI Hideo, 杉田之宏
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  JUNTENDO UNIVERSITY
Mutational and functional analyses of the parkin responsible for AR-JP
- Principal Investigator
  
  HATTORI Nobutaka
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  JUNTENDO UNIVERSITY
Research for the pathogenesis of Parkinson's disease (microdyalisi study for neurotxin)Principal Investigator
- Principal Investigator
  
  MIZUNO Yoshikuni, 田久保秀樹
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  JUNTENDO UNIVERSITY
GENETIC BACKGROUND OF SPORADIC PARKINSON'S DISEASE
- Principal Investigator
  
  KOBAYASHI Tomonori
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  JUNTENDO UNIVERSITY
遺伝的素因と環境因子の相互作用による神経細胞死Principal Investigator
- Principal Investigator
  
  水野美邦
- Project Period (FY)
  1997 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Juntendo University
Molecular Mechanisms of Neuronal Death and Strategies for NeuroprotectionPrincipal Investigator
- Principal Investigator
  
  MIZUNO Yoshikuni
- Project Period (FY)
  1997 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  JUNTENDO UNIVERSITY
Apoptosis in neuronal cell death of neurodegenerative disorders.
- Principal Investigator
  
  MORI Hideo
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  JUNTENDO UNIVERSITY
外因による脳神経細胞死のモデルとその応用
- Principal Investigator
  
  太田茂
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
神経細胞死とその防御の分子制御Principal Investigator
- Principal Investigator
  
  水野美邦
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neuroscience in general
- Research Institution
  Juntendo University
パ-キソン病におけるミトコンドリア神経毒の研究Principal Investigator
- Principal Investigator
  
  水野美邦
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Juntendo University
パーキンソン病におけるMn Superoxide Dismutase遺伝子
- Principal Investigator
  
  MATSSUMINE Hiroto
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Juntendo University
パーキンソン病におけるミトコンドリア蛋白遺伝子異常Principal Investigator
- Principal Investigator
  
  水野美邦
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Juntendo University
神経細胞死のメカニズムと防御に関する研究Principal Investigator
- Principal Investigator
  
  水野美邦
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Juntendo University
神経難病における神経細胞死の機序と修復・防御
- Principal Investigator
  
  吉田充男
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Jichi Medical University
神経細胞死のメカニズムと防御に関する研究Principal Investigator
- Principal Investigator
  
  水野美邦
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Juntendo University
神経難病における神経細胞死の機序と修復・防御
- Principal Investigator
  
  吉田充男
- Project Period (FY)
  1991 – 1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Jichi Medical University
神経難病における神経細胞死の機序と修復・防御
- Principal Investigator
  
  吉田充男
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Institution
  Jichi Medical University
運動系における制御機構
- Principal Investigator
  
  吉田充男
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Jichi Medical University
運動系の変性と修復の成立過程
- Principal Investigator
  
  楢林博太郎
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Juntendo University

All 2007 2006 2005 2004 2003 2002 2001

All Journal Article Presentation Book

[Book] Elsevier2007
- Author(s)
  Mizuno, Y・Hattori, N・Mochiduki, H・Koller, W・Melamed, E.
- Publisher
  Genetic Aspects of Parkinson's Disease. In Handbook of Clinical Neurology, eds
- Data Source
  KAKENHI-PROJECT-17025037
[Book] Neuroprotection. In Treatment of Parkinson's disease. Shapira AHV and Olanow CW, (Ed)Woburn2006
- Author(s)
  Mochizuki H, Mizuno Y
- Publisher
  Elsevier Science Publishers(In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390255
[Book] Neuroprotection. In Treatment of Parkinson's disease. (Shapira AHV and Olanow CW,(Ed)) Woburn2006
- Author(s)
  Mochizuki H, Mizuno Y
- Publisher
  Elsevier Science Publishers(In press)
- Data Source
  KAKENHI-PROJECT-17659268
[Book] Treatment of Parkinson's disease. "Neuroprotection." (Shapira AHV and Olanow CW, (Ed))2006
- Author(s)
  Mochizuki H, Mizuno Y
- Publisher
  Elsevier Science Publishers, Woburn (In press)
- Data Source
  KAKENHI-PROJECT-16390255
[Book] Pathophysiology of Parkinson's Disease, Neurochemical Pathology2005
- Author(s)
  Mizuno Y
- Publisher
  CEC Press
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13210122
[Book] Pathophysiology of Parkinson's Disease2005
- Author(s)
  Mizuno Y
- Publisher
  CEC Press
- Data Source
  KAKENHI-PROJECT-17025037
[Book] Molecular Mechanism in Parkinson's disease : Do familial Parkinson's disease genes share a common pathway involved in the nigral degeneration?(Edited by Phillip Kahle and Christian Haass)2004
- Author(s)
  Hattori N, Mizuno Y, et al.
- Publisher
  Eurekah com, Germany(In press)
- Data Source
  KAKENHI-PROJECT-15390277
[Book] Genetics of Movement Disorders2003
- Author(s)
  Mizuno Y et al.
- Publisher
  Academic Press
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13210122
[Book] Nature Encyclopedia of the Human Genome2003
- Author(s)
  Hattori N, Mizuno Y
- Total Pages
  4000
- Publisher
  Nature publishing group
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390277
[Journal Article] Dopaminergic neuronal dysfunction associated with parkinsonism in both a Gaucher disease patient and a carrier2007
- Author(s)
  Kono S, Shirakawa K, Ouchi Y, Sakamoto M, Ida H, Sugiura T, Tomiyama H, Suzuki H, Takahashi Y, Miyajima H, Hattori N, Mizuno Y
- Journal Title
  
  J Neurol Sci 252
  
  Pages: 181-184
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390256
[Journal Article] Prognosis of Parkinson's disease : time to stage III, IV, V, and to motor fluctuations2007
- Author(s)
  Sato K, Hatano T, Yamashiro K, Kagohashi M, Nishioka K, Izawa N, Mochizuki H, Hattori N, Mori H, Mizuno Y
- Journal Title
  
  Mov Disord 21
  
  Pages: 1384-1395
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390256
[Journal Article] Dopaminergic neuronal dysfunction associated with parkinsonism in both a Gaucher disease patient and a carrier2007
- Author(s)
  Kono S, Shirakawa K, Ouchi Y, Sakamoto M, Ida H, Sugiura T, Tomiyama H, Suzuki H, Takahashi Y, Miyajima H, Hattori N, Mizuno Y.
- Journal Title
  
  J Neurol Sci 252
  
  Pages: 181-184
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390256
[Journal Article] Leucine-rich repeat kinase 2 associates with lipid rafts2007
- Author(s)
  Hatano, T・Kubo, S・Imai, S・Maeda, M・Ishikawa, K・Mizuno, Y・HattoriN
- Journal Title
  
  Hum Mol Genet 16
  
  Pages: 678-690
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025037
[Journal Article] Leucine-rich repeat kinase 2 associates with lipid rafts2007
- Author(s)
  Hatano T, Kubo SI, Imai S, Maeda M, Ishikawa K, Mizuno Y, Hattori N
- Journal Title
  
  Hum Mol Genet 16
  
  Pages: 678-690
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390256
[Journal Article] The isolation of neural stem cells from olfactory bulb of Parkinson's disease model.2007
- Author(s)
  Hayakawa, H・Hayashita-Kinoh, H・Nihira, T・Mizuno, Y・Mochizuki, H
- Journal Title
  
  Neurosci Res 57
  
  Pages: 393-398
- NAID
  10024413286
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025037
[Journal Article] Decline of striatal dopamine release in parkin-deficient mice shown by ex vivo autoradiography2007
- Author(s)
  Sato S, Chiba T, Nishiyama S, Kakiuchi T, Tsukada H, Hatano T, Fukuda T, Yasoshima Y, Kai N, Kobayashi K, Mizuno Y, Tanaka K, Hattori N
- Journal Title
  
  J Neurosci Res 84
  
  Pages: 1350-1357
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390256
[Journal Article] LRRK2 G2385R variant is a risk factor for Parkinson disease in Asian population2007
- Author(s)
  Funayama M, Li Y, Tomiyama H, Yoshino H, Imamichi Y, Yamamoto M, Murata M, Toda T, Mizuno Y, Hattori N
- Journal Title
  
  Neuroreport 18
  
  Pages: 273-275
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390256
[Journal Article] Neuropsychiatric and cognitive features in autosomal-recessive early parkinsonism due to PINK1 mutations2007
- Author(s)
  Hatano T, Kubo SI, Imai S, Maeda M, Ishikawa K, Mizuno Y, Hattori N
- Journal Title
  
  Hum Mol Genet Mar 6 (epub ahead of print)
- Data Source
  KAKENHI-PROJECT-17390256
[Journal Article] Down-regulation of alpha-synuclein expression can rescue dopaminergic cells from cell death in the substantia nigra of Parkinson's disease rat model.2006
- Author(s)
  Hayashita-Kinoh H, Yamada M, Yokota T, Mizuno Y, Mochizuki H
- Journal Title
  
  Biochem Biophys Res Commun Mar 24; 341(4)
  
  Pages: 1088-95
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390255
[Journal Article] Down-regulation of alpha-synuclein expression can rescue dopaminergic cells from cell death in the substantia nigra of Parkinson's disease rat model.2006
- Author(s)
  Hayashita-Kinoh H, Yamada M, Yokota T, Mizuno Y, Mochizuki H
- Journal Title
  
  Biochem Biophys Res Commun. Mar 24;341(4)
  
  Pages: 1088-1095
- Data Source
  KAKENHI-PROJECT-16390255
[Journal Article] Intrinsic and extrinsic erythropoietin enhances neuroprotection against ischemia and reperfusion injury in vitro.2006
- Author(s)
  Liu R, Suzuki A, Guo Z, Mizuno Y, Urabe T
- Journal Title
  
  Journal of Neurochem 96
  
  Pages: 1101-1110
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590897
[Journal Article] Diverse effects of pathogenic mutations of Parkin that catalyze multiple monoubiquitylation in vitro2006
- Author(s)
  Matsuda, Mizuno, et al.
- Journal Title
  
  J Biol Chem 281
  
  Pages: 3204-3209
- Data Source
  KAKENHI-PROJECT-17025037
[Journal Article] Nuclear localization of the 20S proteasome subunit in Parkinson's disease2006
- Author(s)
  Nakamura A, Kitami T, Mori H, Mizuno Y, Hattori N
- Journal Title
  
  Neurosci Lett 406 : 43-48, 2006 406
  
  Pages: 43-48
- Data Source
  KAKENHI-PROJECT-17390256
[Journal Article] Clinical heterogeneity of alpha-synuclein gene duplication in Parkinson's disease2006
- Author(s)
  Nishioka, Mizuno, et al.
- Journal Title
  
  Ann Neurol 59
  
  Pages: 298-309
- Data Source
  KAKENHI-PROJECT-17025037
[Journal Article] 14-3-3h is a novel regulator of parkin ubiquitin-ligase2006
- Author(s)
  Sato S, Chiba, Tanaka K, T, Mizuno Y, Hattori N, et al.
- Journal Title
  
  EMBOJ (In press)
- Data Source
  KAKENHI-PROJECT-17025037
[Journal Article] Positive immunoreactivity for vesicular monoamine transporter 2 in Lewy bodies and Lewy neurites in substantia nigra2006
- Author(s)
  Yamamoto S, Fukae J, Mori H, Mizuno Y, Hattori N
- Journal Title
  
  FEBS Lett 580
  
  Pages: 187-191
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390256
[Journal Article] Progress in familial Parkinson's disease2006
- Author(s)
  Mizuno, Hattori, et al.
- Journal Title
  
  J Neural Transm Suppl 70
  
  Pages: 191-204
- NAID
  130003670526
- Data Source
  KAKENHI-PROJECT-17025037
[Journal Article] Recessive Parkinson's disease2006
- Author(s)
  Kubo S, Hattori N, Mizuno Y
- Journal Title
  
  Mov Disord. 21
  
  Pages: 885-893
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390256
[Journal Article] Neuroprotective effect of recombinant human granulocyte colony-stimulating factor in transient focal ischemia of mice.2006
- Author(s)
  Komine-Kobayashi M, Zhang N, Liu M, Tanaka R, Hara H, Osaka A, Mochizuki H, Mizuno Y, Urabe T.
- Journal Title
  
  Journal of Cerebral Blood Flow and Metabolism 26
  
  Pages: 402-413
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590897
[Journal Article] Clinical heterogeneity of alpha-synuclein gene duplication in Parkinson's disease2006
- Author(s)
  Nishioka K, Hayashi S, Farrer MJ, Singleton AB, Yoshino H, Imai H, Kitami T, Sato K, Kuroda R, Tomiyama H, Mizoguchi K, Murata M, Toda T, Imoto I, Inazawa J, Mizuno Y, Hattori N
- Journal Title
  
  Ann Neurol 59
  
  Pages: 298-309
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390256
[Journal Article] Down-regulation of alpha-synuclein expression can rescue dopaminergic cells from cell death in the subatantia nigra of Parkinson's disease rat model.2006
- Author(s)
  Hayashita-Kinoh H, Yamada M, Yokota T, Mizuno Y, Mochizuki H
- Journal Title
  
  Biochem Biophys Res Commun. Mar24;341(4)
  
  Pages: 1088-1095
- Data Source
  KAKENHI-PROJECT-17659268
[Journal Article] Characterization of multimetric variants of ubiquitin carboxyl-terminal Hydrolase L1 in water by small-angle neutron scattering.2006
- Author(s)
  Naito S, Mochizuki H, Yasuda T, Mizuno Y, Furusaka M, Ikeda S, Adachi T, Shimizu H, Suzuki J, Fujiwara S, Okada T, Nishikawa K, Aoki S, Wada K
- Journal Title
  
  Biochem Biophys Res Commun 339(2)
  
  Pages: 717-725
- Data Source
  KAKENHI-PROJECT-17659268
[Journal Article] Progress in familial Parkinson' s disease.2006
- Author(s)
  Yoshikuni Mizuno
- Journal Title
  
  J Neural Transm. 70
  
  Pages: 191-204
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590895
[Journal Article] 14-3-3 eta is a novel regulator of parkin ubiquitin-ligase2006
- Author(s)
  Sato S, Chiba T, Sakata E, Kato K, Mizuno Y, Hattori N, Tanaka K
- Journal Title
  
  EMBO J 25
  
  Pages: 211-221
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390256
[Journal Article] Decline of striatal dopamine release in parkin-deficient mice shown by ex vivo autoradiography2006
- Author(s)
  Sato S, Chiba T, Nishiyama S, Kakiuchi T, Tsukaba H, Hatano T, Fukuda T, Yasoshima Y, Kai N, Kobayashi K, Mizuno Y, Tanaka K, Hattori N
- Journal Title
  
  J Neurosci Res 84
  
  Pages: 1350-1357
- Data Source
  KAKENHI-PROJECT-17390256
[Journal Article] Recessive Parkinson's disease2006
- Author(s)
  Kubo S, Hattori N, Mizuno Y
- Journal Title
  
  Mov Disord 21
  
  Pages: 885-893
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390256
[Journal Article] own-regulation of alpha-synuclein expression can rescue dopaminergic cells from cell death in the substantia nigra of Parkinson's disease rat model2006
- Author(s)
  Hayashita-Kinoh, Mizuno, et al.
- Journal Title
  
  Biochem Biophys Res Commun 341
  
  Pages: 1088-1095
- Data Source
  KAKENHI-PROJECT-17025037
[Journal Article] Nuclear localization of the 20S proteasome subunit in Parkinson's disease2006
- Author(s)
  Nakamura A, Kitami T, Mori H, Mizuno Y, Hattori N
- Journal Title
  
  Neurosci Lett 406
  
  Pages: 43-48
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390256
[Journal Article] Clinicogenetic study of mutations in LRRK2 exon 41 in Parkinson's disease patients from 18 countries2006
- Author(s)
  Tomiyama H, Li Y, Funayama M, Hasegawa K, Yoshino H, Kubo S, Sato K, Hattori T, Lu C-S, Inzelberg R, Djaldetti R, Melamed E, Amouri R, Gouider-Khouja N, Hentati F, Hatano Y, Wang M, Imamichi Y, Mizoguchi K, Miyajima H, Obata F, Toda T, Farrer MJ, Mizuno Y, Hattori N
- Journal Title
  
  Mov Disord 21
  
  Pages: 1102-1108
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390256
[Journal Article] Decline of striatal dopamine release in parkin-deficient mice shown by ex vivo autoradiography2006
- Author(s)
  Sato S, Chiba T, Nishiyama S, Kakiuchi T, Tsukada H, Hatano T, Fukuda T, YasoshimaY, Kai N, Kobayashi K, Mizuno Y, Tanaka K, Hattori N
- Journal Title
  
  J Neurosci Res 84
  
  Pages: 1350-1357
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390256
[Journal Article] Cilostazol protects against brain white matter damage and cognitive impairment in a rat model of chronic cerebral hypoperfusion.2006
- Author(s)
  Watanabe T, Zhang N, Liu M, Tanaka R, Mizuno Y, Urabe T
- Journal Title
  
  Stroke 37
  
  Pages: 1539-1545
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590897
[Journal Article] Positive immunoreactivity for vesicular monoamine transporter 2 in Lewy bodies and Lewy neurites in substantia nigra2006
- Author(s)
  Yamamoto S, Fukae J, Mori H, Mizuno Y, Hattori N
- Journal Title
  
  Neurosci Lett 396
  
  Pages: 187-191
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390256
[Journal Article] Down-regulation of alpha-synuclein expression can rescue dopaminergic cells from cell death in the substantia nigra of Parkinson's disease rat model.2006
- Author(s)
  Hayashita-Kinoh H, Yamada M, Yokota T, Mizuno Y, Mochizuki H.
- Journal Title
  
  Biochem Biophys Res Commun. 341(4)
  
  Pages: 1088-1095
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390255
[Journal Article] Characterization of multimetric variants of ubiquitin carboxyl-terminal Hydrolase L1 in water by small-angle neutron scattering.2006
- Author(s)
  Naito S, Mochizuki H, Yasuda T, Mizuno Y, Furusaka M, Ikeda S, Adachi T, Shimizu H, Suzuki J, Fujiwara S, Okada T, Nishikawa K, Aoki S, Wada K
- Journal Title
  
  Biochem Biophys Res Commun 339(2)
  
  Pages: 717-725
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390255
[Journal Article] Decline of striatal dopamine rlease in parkin-deficient mice shown by exvivo autoradiography2006
- Author(s)
  Sato, Mizuno, et al.
- Journal Title
  
  J Neurosci Res 84
  
  Pages: 1350-1357
- Data Source
  KAKENHI-PROJECT-17025037
[Journal Article] Dominant-negative effect of mutant valosin-containing protein in aggresome formation2006
- Author(s)
  Kitami MI, Kitami T, Nagahama M, Tagaya M, Hori S, Kakizuka A, Mizuno Y, Hattori N
- Journal Title
  
  FEBS Lett 580
  
  Pages: 474-478
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390256
[Journal Article] Clinicogenetic study of mutations in LRRK2 exon 41 in Parkinson's disease patients from 18 countries.2006
- Author(s)
  Tomiyama, Mizuno, et al.
- Journal Title
  
  Mov Disord 21
  
  Pages: 1102-1108
- Data Source
  KAKENHI-PROJECT-17025037
[Journal Article] Progress in familial Parkinson's disease.2006
- Author(s)
  水野美邦
- Journal Title
  
  J Neural Transm 70
  
  Pages: 191-204
- NAID
  130003670526
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590895
[Journal Article] Prognosis of Parkinson's disease : time to stage III, IV, V, and to motor fluctuations.2006
- Author(s)
  Sato K, Hatano T, Yamashiro K, Kagohashi M, Nishioka K, Izawa N, Mochizuki H, Hattori N, Mori H, Mizuno Y
- Journal Title
  
  Mov Disord 21
  
  Pages: 1384-1395
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390256
[Journal Article] Diverse effects of pathogenic mutations of Parkin that catalyzes multiple monoubiquitylation in vitro2006
- Author(s)
  Matsuda N, Kitami T, Suzuki T, Mizuno Y, Hattori N, Tanaka K
- Journal Title
  
  J Biol Chem 281
  
  Pages: 3204-3209
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390256
[Journal Article] Characterization of multimetric variants of ubiquitin carboxyl-terminal Hydrolase L1 in water by small-angle neutron scattering.2006
- Author(s)
  Naito S, Mochizuk H, Yasuda T, Mizuno Y, Furusaka M, Ikeda S, Adachi T, Shimizu H, Suzuki J, Fujiwara S, Okada T, Nishikawa K, Aoki S, Wada K
- Journal Title
  
  Biochem Biophys Res Commun 339(2)
  
  Pages: 717-725
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390255
[Journal Article] Edaravone reduces early accumulation of oxidative products and sequential inflammatory responses after transient focal ischemia in mice brain.2005
- Author(s)
  Zhang N, Liu M, Komine-Kobayashi M, Tanaka R, Liu M, Mizuno Y, Urabe T
- Journal Title
  
  Stroke 36
  
  Pages: 2220-2225
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590897
[Journal Article] Pro-apoptotic protein glyceraldehyde-3-phosphate dehydrogenase promotes the formation of Lewy body-like inclusions.2005
- Author(s)
  Tsuchiya K, Tajima H, Kuwae T, Takeshima T, Nakano T, Tanaka M, Sunaga K, Fukuhara Y, Nakashima K, Ohama E, Mochizuki H, Mizuno Y, Katsube N, Ishitani R.
- Journal Title
  
  Eur J Neurosci Jan; 21(2)
  
  Pages: 317-26
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390255
[Journal Article] Pro-apoptotic protein glyceraldehyde-3-phosphate dehydrogenase promotes the formation of Lewy body-like inclusions.2005
- Author(s)
  Tsuchiya K, Tajima H, Kuwae T, Takeshima T, Nakano T, Tanaka M, Sunaga K, Fukuhara Y, Nakashima K, Ohama E, Mochizuki H, Mizuno Y, Katsube N, Ishitani R.
- Journal Title
  
  Eur J Neurosci. Jan;21(2)
  
  Pages: 317-326
- Data Source
  KAKENHI-PROJECT-17659268
[Journal Article] Possibility for neurogenesis in substantia nigra of parkinsonian brain.2005
- Author(s)
  Yoshimi K, Ren YR, Seki T, Yamada M, Ooizumi H, Onodera M, Saito Y, Murayama S, Okano H, Mizuno Y, Mochizuki H.
- Journal Title
  
  Ann Neurol. Jul;58(1)
  
  Pages: 31-40
- Data Source
  KAKENHI-PROJECT-17659268
[Journal Article] Parkin inhibits alpha-synucleinopathy in rat substantia nigra.2005
- Author(s)
  Yamada M, Iwatsubo T, Mizuno Y, Mochizuki H.
- Journal Title
  
  Hum Gene Ther. Feb;16(2)
  
  Pages: 262-270
- Data Source
  KAKENHI-PROJECT-17659268
[Journal Article] Clinicogenetic study of PINK1 mutations in autosomal recessive early-onset parkinsonism2005
- Author(s)
  Li Y, Tomiyama H, Mizuno Y, Hattori N, et al.
- Journal Title
  
  Neurology 64
  
  Pages: 1955-1957
- Data Source
  KAKENHI-PROJECT-17025037
[Journal Article] Parkin Gene Therapy for α-Synucleinopathy : A Rat Model of Parkinson's disease2005
- Author(s)
  Yamada M, Mizuno Y, Mochizuki H
- Journal Title
  
  Hum Gene Therapy 16
  
  Pages: 262-270
- Data Source
  KAKENHI-PROJECT-17025037
[Journal Article] Pathophysiology of Parkinson's Disease, Neurochemical Pathology2005
- Author(s)
  Mizuno Y
- Journal Title
  
  CEC Press
  
  Pages: 443-477
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210122
[Journal Article] Possibility for neurogenesis in substantia nigra of parkinsonian brain.2005
- Author(s)
  Yoshimi K, Ren YR, Seki T, Yamada M, Ooizumi H, Onodera M, Saito Y, Murayama S, Okano H, Mizuno Y, Mochizuki H.
- Journal Title
  
  Ann Neurol. 58(1)
  
  Pages: 31-40
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390255
[Journal Article] Parkin inhibits alpha-synucleinopathy in rat substantia nigra.2005
- Author(s)
  Yamada M, Iwatsubo T, Mizuno Y, Mochizuki H.
- Journal Title
  
  Human Gene Therapy 16
  
  Pages: 262-270
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390255
[Journal Article] Phosphorylated IkappaBalpha is a component of Lewy body of Parkinson's Disease2005
- Author(s)
  Noda K, Kitami T, Mizuno Y, Hattori N, et al.
- Journal Title
  
  Biochem Biophys Res Commun 331
  
  Pages: 309-317
- Data Source
  KAKENHI-PROJECT-17025037
[Journal Article] Common ani-apoptptic roles of parkin and α-synuclein in human dopaminergic cell2005
- Author(s)
  Machida Y, Chiba T, Tanaka Y, Mizuno Y, Hatori N et al.
- Journal Title
  
  Biochem Biophys Res Commun 332
  
  Pages: 233-240
- Data Source
  KAKENHI-PROJECT-17025037
[Journal Article] Parkin inhibits alpha-synucleinopathy in rat substantia nigra.2005
- Author(s)
  Yamada M, Iwatsubo T, Mizuno Y, Mochizuki H.
- Journal Title
  
  Hum Gene Ther. Feb; 16(2)
  
  Pages: 262-70
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390255
[Journal Article] The fate of neural progenitor cells expressing astrocytic and glial markers in the postnatal rat dentate gyrus.2005
- Author(s)
  Namba T, Mochizuki H, Onodera M, Mizuno Y, Namiki H, Seki T
- Journal Title
  
  Eur J Neurosci. Oct;22(8)
  
  Pages: 1928-1941
- Data Source
  KAKENHI-PROJECT-17659268
[Journal Article] Possibility for neurogenesis in substantia nigra of parkinsonian brain.2005
- Author(s)
  Yoshimi K, Ren YR, Seki T, Yamada M, Ooizumi H, Onodera M, Saito Y, Murayama S, Okano H, Mizuno Y, Mochizuki H.
- Journal Title
  
  Ann Neurol. Jul; 58(1)
  
  Pages: 31-40
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390255
[Journal Article] Parkin inhibits alpha-synucleinopathy in rat substantia nigra.2005
- Author(s)
  Yamada M, Iwatsubo T, Mizuno Y, Mochizuki H.
- Journal Title
  
  Hum Gene Ther. Feb;16(2)
  
  Pages: 262-270
- Data Source
  KAKENHI-PROJECT-16390255
[Journal Article] Phosphtorylated I κ ka is a component of Lewy body of Parkinson's disease2005
- Author(s)
  Noda K, Mizuno Y. et al.
- Journal Title
  
  Biochem Biophy Res Commun 331
  
  Pages: 309-317
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13210122
[Journal Article] Possibility for Neurogenesis in Substantia Nigra of Parkinsonian2005
- Author(s)
  Yoshimi K, Young RR, Mizuno Y, Mochizuki H, et al.
- Journal Title
  
  Ann Neurol 58
  
  Pages: 58-31
- Data Source
  KAKENHI-PROJECT-17025037
[Journal Article] Pro-apoptotic protein glyceraldehyde-3-phosphate dehydrogenase promotes the formation of Lewy body-like inclusions.2005
- Author(s)
  Tsuchiya K, Tajima H, Kuwae T, Takeshima T, Nakano T, Tanaka M, Sunaga K, Fukuhara Y, Nakashima K, Ohama E, Mochizuki H, Mizuno Y, Katsube N, Ishitani R.
- Journal Title
  
  Eur J Neurosci. Jan;21(2)
  
  Pages: 317-326
- Data Source
  KAKENHI-PROJECT-16390255
[Journal Article] Parkin gene therapy for α-synucleinopathy : A rat model of Parkinson's disease.2005
- Author(s)
  Yamada M, Mizuno Y, Mochizuki H.
- Journal Title
  
  Hum Gene Therapy 16
  
  Pages: 262-270
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210122
[Journal Article] Pro-apoptotic protein glyceraldehyde-3-phosphate dehydrogenase promotes the formation of Lewy body-like inclusions.2005
- Author(s)
  Tsuchiya K, Tajima H, Kuwae T, Takeshima T, Nakano T, Tanaka M, Sunaga K, Fukuhara Y, Nakashima K, Ohama E, Mochizuki H. Mizuno Y, Katsube N, Ishitani R
- Journal Title
  
  Eur J Neurosci. 21(2)
  
  Pages: 317-326
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390255
[Journal Article] Phosphtorylated I κ kα is a component of Lewy body of Parkinson's disease.2005
- Author(s)
  Noda K, Kitami T, Gai WP, Chegini F, Jensen PH, Fimura T, Murayama K, Tanaka K, Mizuno Y, Hattori N.
- Journal Title
  
  Biom Biophy Res Commun 331
  
  Pages: 309-317
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210122
[Journal Article] Possibility for neurogenesis in substantia nigra of parkinsonian brain.2005
- Author(s)
  Yoshimi K, Ren YR, Seki T, Yamada M, Ooizumi H, Onodera M, Saito Y, Murayama S, Okano H, Mizuno Y, Mochizuki H.
- Journal Title
  
  Ann Neurol. Jul;58(1)
  
  Pages: 31-40
- Data Source
  KAKENHI-PROJECT-16390255
[Journal Article] Parkin and endoplasimic reticulum stress.2004
- Author(s)
  Takahashi R, Mizuno Y. et al.
- Journal Title
  
  Ann NY Acad Sci 99
  
  Pages: 101-106
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13210122
[Journal Article] Parkin attenuates manganese-induced dopaminergic cell death.2004
- Author(s)
  Higashi Y, Mizuno Y. et al.
- Journal Title
  
  J Biol Chem 89
  
  Pages: 1490-1497
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13210122
[Journal Article] Functional Effects of NAD(P)H Oxidase p22phox C242T Mutation in Human Leukocytes and Association with Thrombotic Cerebral Infarction.2004
- Author(s)
  Shimo Y, Hasebe T, Suzuki A, Mochizuki H, Tanaka Y, Nagaoka I, Mizuno Y, Urabe T.
- Journal Title
  
  Atherosclerosis: 175
  
  Pages: 109-115
- Data Source
  KAKENHI-PROJECT-16390255
[Journal Article] Ubiquitin, proteasome and parkin2004
- Author(s)
  Tanaka K, Mizuno Y. et al.
- Journal Title
  
  Biochim Biophys Acta 1695
  
  Pages: 235-247
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13210122
[Journal Article] Neurotoxic effects of lipopolysaccharide on nigral dopaminergic neurons are mediated by microglial activation, interl eukin-1 β,and expression of caspase-11 in mice.2004
- Author(s)
  Arai H, Mizuno Y. et al.
- Journal Title
  
  J Biol Chem 279
  
  Pages: 51647-51653
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13210122
[Journal Article] Ubiquitin, proteasome and parkin.2004
- Author(s)
  Tanaka K, Suzuki T, Hattori N, Mizuno Y.
- Journal Title
  
  Biochim Biophys Acta 29 1695
  
  Pages: 235-247
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210122
[Journal Article] Neurogenesis After Transient Global Ischemia in the Adult Hippocampus Visualized by Improved Retroviral Vector.2004
- Author(s)
  Tanaka R, Yamashiro K, Mochizuki H, Cho N, Onodera M, Mizuno Y, Ur
- Journal Title
  
  Stroke. 35(6)
  
  Pages: 1454-1459
- Data Source
  KAKENHI-PROJECT-16390255
[Journal Article] Neurogenesis in olfactory bulb identified by retroviral labeling in normal and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated adult mice.2004
- Author(s)
  Yamada M, Onodera M, Mizuno Y, Mochizuki H.
- Journal Title
  
  Neuroscience. 124
  
  Pages: 173-181
- Data Source
  KAKENHI-PROJECT-16390255
[Journal Article] PARK6-linked autosomal recessive early-onset parkinsonism In Asian populations.2004
- Author(s)
  Hatano Y, Sato K, Elibol B, Yoshino H, Yamamura Y, Bonifati V Shinotoh H, Asahina M, Kobayshi S, Ng Ar, RosalesRL, Hassin-Bear S, Shinar Y, Lu CS, Chang HC, Wu Chou Y, Atac FB, Kobayashi T, Toda T, Mizuno Y, Hattori N.
- Journal Title
  
  Neurology 63
  
  Pages: 1482-1485
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210122
[Journal Article] Pathogenetic mechanisms of parkin in Parkisnson's disease2004
- Author(s)
  Hattori N, Mizuno Y
- Journal Title
  
  Lancet 364
  
  Pages: 21-27
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390277
[Journal Article] Novel PINK 1 mutations in early-onset parkinsonism.2004
- Author(s)
  Hatano Y, Li Y, Sato K, Asakwa S, Yamamura Y, Tomiyama H, Yoshino H, Asahina M, Kobyshi S, Ng Ar, Rosals RL, Hassin-Bear S, Shinar Y, Lu CS, Shimizu N, Toda T, Mizuno Y, Hattori N.
- Journal Title
  
  Ann Neuro 56
  
  Pages: 424-427
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210122
[Journal Article] Neurotoxic effects of lipopolysaccharide on nigral dopaminergic neurons are mediated by microglial activation, interleukin-1b, and expression of caspase-11 in mice.2004
- Author(s)
  Arai H, Furuya T, Miura M, Mizuno Y, Mochizuki H.
- Journal Title
  
  J Biol Chem 79
  
  Pages: 51647-51653
- Data Source
  KAKENHI-PROJECT-16390255
[Journal Article] Neurotoxic effects of lipopolysaccharide on nigral dopaminergic neurons are mediated by microglial activation, interleukin-1 β, and expression of caspase-11 in mice.2004
- Author(s)
  Arai H, Furuya T, Yasuda T, Miura M, Mizuno Y, Mochizuki H.
- Journal Title
  
  J Biol Chem 279
  
  Pages: 51647-51653
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210122
[Journal Article] Pathogenetic mechanisms of parkin in Parkisnosn's disease.2004
- Author(s)
  Hattori N, Mizuno Y
- Journal Title
  
  Lancet 364
  
  Pages: 722-724
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390277
[Journal Article] Dual role of Fcgamma receptor in transient focal cerebral ischemia in mice.2004
- Author(s)
  Komine M, Chou N, Mochizuki H, Nakao A, Mizuno Y, Urabe T.
- Journal Title
  
  Stroke 35(4)
  
  Pages: 958-963
- Data Source
  KAKENHI-PROJECT-16390255
[Journal Article] Pathogenetic mechanisms of parkin in Parkinson's disease.2004
- Author(s)
  Hattori N, Mizuno Y.
- Journal Title
  
  Lancet 364
  
  Pages: 722-724
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210122
[Journal Article] Over expression of a-synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of a-synuclein and activation of caspase-9 : resemblance to pathogenetic changes in Parkinson's disease.2004
- Author(s)
  Yamada M, Iwatubo T, Mizuno Y, Mochizuki H.
- Journal Title
  
  J Neurochem 91
  
  Pages: 451-461
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210122
[Journal Article] Pathogenetic mechanisms of parkin in Parkinson's disease2004
- Author(s)
  Hattori N, Mizuno Y
- Journal Title
  
  Lancet 364
  
  Pages: 722-724
- Data Source
  KAKENHI-PROJECT-15390277
[Journal Article] Ubiquitin, proteasome and parkin2004
- Author(s)
  Tanaka K, Suzuki T, Hattori N, Mizuno Y
- Journal Title
  
  Biochim Biophys Acta 1695
  
  Pages: 235-247
- Data Source
  KAKENHI-PROJECT-15390277
[Journal Article] Overexpression of α-synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of α-synuclein and activation of caspase2004
- Author(s)
  Yamada M, Iwatsubo T, Mizuno Y, Mochizuki H.
- Journal Title
  
  Neurochem 91
  
  Pages: 451-161
- Data Source
  KAKENHI-PROJECT-16390255
[Journal Article] Pathogenetic mechanisms of parkin in Parkinson's disease2004
- Author(s)
  Hattori N, Mizuno Y
- Journal Title
  
  Lancet 364
  
  Pages: 722-724
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13210122
[Journal Article] Parkin attenuates manganese-induced dopaminergic cell death.2004
- Author(s)
  Higashi Y, Asanuma M, Miyazaki I, Hattori N, Mizuno Y, Ogawa N.
- Journal Title
  
  J Biol Chem 89(6)
  
  Pages: 1490-1497
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210122
[Journal Article] Parkin and endoplasimic reticulum stress.2004
- Author(s)
  Takahashi R, Imai Y, Hattori N, Mizuno Y.
- Journal Title
  
  Ann NY Acad Sci 99
  
  Pages: 101-106
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210122
[Journal Article] PARK6-linked autosomal recessive early-onset parkinsonism In Asian populations2004
- Author(s)
  Hatano Y, Mizuno Y. et al.
- Journal Title
  
  Neurology 63
  
  Pages: 1482-1485
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13210122
[Journal Article] A novel L266V mutation of the tau gene causes frontotemporal dementia with a unique tau pathology.2003
- Author(s)
  Kobayashi T, Mizuno Y. et al.
- Journal Title
  
  Ann. Neurol 53
  
  Pages: 133-137
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13210122
[Journal Article] Parkin cleaves intracellular alpha-synuclein inclusions via the activation of calpain.2003
- Author(s)
  Kim SJ, Sung JY, Urn JW, Hattori N, Mizuno Y, Tanaka K, Paik SR, Kim J, Chung KC.
- Journal Title
  
  J Biol Chem. 278
  
  Pages: 41890-41899
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210122
[Journal Article] Haploinsufficiency at the a-synuclein gene underlies phenotypic severity in familial Parkinson's disease.2003
- Author(s)
  Kobayashi H, Kruger R, Markopoulou K, Wszolek Z, Chase B, Taka H, Mineki R, Murayama K, Riess O, Mizuno Y, Hattori N.
- Journal Title
  
  Brain. 126(Pt 1)
  
  Pages: 32-42
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210122
[Journal Article] Genetics of Movement Disorders2003
- Author(s)
  Mizuno Y et al.
- Journal Title
  
  Academic Press
  
  Pages: 305-314
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210122
[Journal Article] Parkin cleaves intracellular alpha-synuclein inclusions via the activation of calpain.2003
- Author(s)
  Kim SJ, Mizuno Y. et al.
- Journal Title
  
  J Biol Chem. 278
  
  Pages: 41890-41899
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13210122
[Journal Article] A novel L266V mutation of the tau gene causes frontotemporal dementia with a unique tau pathology.2003
- Author(s)
  Kobayashi T, Ota S, Tanaka K, Ito Y, Hasegawa M, Umeda Y, Motoi Y, Takanashi M, Yasuhara M, Anno M, Mizuno Y, Mori H.
- Journal Title
  
  Ann.Neurol. 53
  
  Pages: 133-137
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210122
[Journal Article] Effect of wild-type or mutant Parkin on oxidative damage nitic oxide antioxidant defenses, and the proteasome.2002
- Author(s)
  Hyun DH, Lee M, Hattori N, Kubo S, Mizuno Y, Halliwell B, Jenner P.
- Journal Title
  
  J Biol Chem 277(32)
  
  Pages: 28572-28577
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210122
[Journal Article] Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies.2002
- Author(s)
  Schossmacher MG, Frosch MP, Ping-Gai W, Medina M, Sharma N, Forno L, Ochiishi T, Shimura H, Sharon R, Hattori N, Langston JW, Mizuno Y, Hyman BT, Selkoe DJ, Kosik K.
- Journal Title
  
  Am J Pathol 160
  
  Pages: 1655-1667
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210122
[Journal Article] Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies.2002
- Author(s)
  Schossmacher MG, Mizuno Y. et al.
- Journal Title
  
  Am J Pathol 160
  
  Pages: 1655-1667
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13210122
[Journal Article] Effect of wild-type or mutant Parkin on oxidative damagnitic oxide antioxidant defenses, and the proteasome2002
- Author(s)
  Hyun DH, Mizuno Y. et al.
- Journal Title
  
  J Biol Chem 277
  
  Pages: 28572-28577
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13210122
[Journal Article] An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of parkin.2001
- Author(s)
  Imai Y, Soda M, Inoue H, Hattori N, Mizuno Y, Takahashi R
- Journal Title
  
  Cell 105
  
  Pages: 891-902
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13210122
[Journal Article] Developmental changes in the expression of parkin and UbcR7, a parkin-interacting and ubiquitin-conjugating enzyme, in rato brain.2001
- Author(s)
  Wang M, Suzuki T, Kitada T, Asakawa S, Minoshima S, Shimizu N, Tanaka K, Mizuno Y, Hattori N.
- Journal Title
  
  J Neurochem 77
  
  Pages: 1561-1568
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210122
[Journal Article] An AAV-derived apaf-1 dominant negative inhibitor prevents MPTP toxicity as antiapoptotic gene therapy for Parkinson's disease.2001
- Author(s)
  Mochizuki H, Hayakawa H, Migita M, Shibata M, Tanaka R, Suzuki A, Shimo-Nakanishi Y, Urabe T, Yamada M, Tamayose K, Shimada T, Miura M, Mizuno Y.
- Journal Title
  
  PNAS 98
  
  Pages: 10918-10923
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210122
[Journal Article] Parkin is associated with cellular vesicles.2001
- Author(s)
  Kubo S, Kitami T, Noda S, Shimura H, Uchiyama Y, Asakawa S, Minoshima S, Shimizu N, Mizuno Y, Hattori N.
- Journal Title
  
  J Neruochem 78
  
  Pages: 42-54
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210122
[Journal Article] Ubiquitination of a new form of a-synuclein by parkin from Human brain : Implications for Parkinson's disease.2001
- Author(s)
  Shimura H, Schlossmacher MG, Hattori N, Frosch MP, Trockenbacher A, Schneider R, Mizuno Y, Kosik KS, Selkoe DJ.
- Journal Title
  
  Science 293
  
  Pages: 263-269
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210122
[Journal Article] An AAV-derived apaf-1 dominant negative inhibitor prevents MPTP toxicity as antiapoptotic gene therapy for Parkinson's disease.2001
- Author(s)
  Mochizuki H, Mizuno Y. et al.
- Journal Title
  
  PNAS 98
  
  Pages: 10918-10923
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13210122
[Journal Article] Ubiquitination of a new form of a-synuclein by parkin from Human brain : Implications for Parkinson's disease.2001
- Author(s)
  Shimura H, Mizuno Y. et al.
- Journal Title
  
  Science 293
  
  Pages: 263-269
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13210122
[Journal Article] Parkin and Parkinson's disease.2001
- Author(s)
  Mizuno Y, Hattori N, Mori H, Suzuki T, Tanaka K.
- Journal Title
  
  Curr Opin Neurol 14
  
  Pages: 477-482
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210122
[Journal Article] Developmental changes in the expression of parkin and UbcR7, a parkin-interacting and ubiquitin-conjugating enzyme, in rato brain.2001
- Author(s)
  Wang M, Mizuno Y. et al.
- Journal Title
  
  J Neurochem 77
  
  Pages: 1561-1568
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13210122
[Journal Article] Parkin is linked to the ubiquitin pathway.2001
- Author(s)
  Tanaka K, Suzuki T, Chiba T, Shimura H, Hattori N, Mizuno Y.
- Journal Title
  
  J Mol Med 79
  
  Pages: 482-494
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210122
[Journal Article] Parkin is linked to the ubiquitin pathway.2001
- Author(s)
  Tanaka K, Mizuno Y. et al.
- Journal Title
  
  J Mol Med 79
  
  Pages: 482-494
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13210122
[Journal Article] An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of parkin.2001
- Author(s)
  Imai Y, Soda M, Inoue H, Hattori N, Mizuno Y, Takahashi R.
- Journal Title
  
  Cell 105
  
  Pages: 891-902
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210122
[Journal Article] Parkin and Parkinson's disease.2001
- Author(s)
  Mizuno Y, Hattori N, Mori H, Suzuki T, Tanaka K
- Journal Title
  
  Curr Opin Neurol 14
  
  Pages: 477-482
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13210122
[Presentation] Is Parkinson's disease hereditary? (Genetic causes of Parkinson's disease).2007
- Author(s)
  Mizuno, Y.・Plenary, Lecture.
- Organizer
  6th International Symposium of the Asian and Pacific Parkinsons Association (APPA).
- Place of Presentation
  Singapore
- Data Source
  KAKENHI-PROJECT-17025037

1. HATTORI Nobutaka (80218510)

# of Collaborated Projects: 14 results

# of Collaborated Products: 53 results
2. MOCHIZUKI Hideki (90230044)

# of Collaborated Projects: 10 results

# of Collaborated Products: 32 results
3. 吉田充男 (70048966)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
4. MATSSUMINE Hiroto (90255670)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
5. MORI Hideo (30150634)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
6. KOHSAKA Shinichi (50112686)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
7. KANAZAWA Ichiro (30110498)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
8. KOBAYASHI Tomonori (50266053)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
9. URABE Takao (60291663)

# of Collaborated Projects: 6 results

# of Collaborated Products: 4 results
10. 永津俊治 (40064802)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
11. SATO Kenichi (00276461)

# of Collaborated Projects: 4 results

# of Collaborated Products: 8 results
12. 榊佳之 (10112327)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
13. 太田茂 (60160503)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
14. 池辺伸一郎 (10212797)

# of Collaborated Projects: 2 results

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# of Collaborated Projects: 2 results

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# of Collaborated Projects: 2 results

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# of Collaborated Projects: 2 results

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# of Collaborated Projects: 2 results

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24. MIGITA Makoto (50256963)

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25. HORI Gen (60322658)

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26. AMARI Shun-ichi (80010726)

# of Collaborated Projects: 1 results

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27. AIHARA Kazuyuki (40167218)

# of Collaborated Projects: 1 results

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28. OKUMA Yasuyuki (90185231)

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29. FUNAKOSHI Hiroshi (40273685)

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54. 田中千賀子 (20025571)

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57. 田久保秀樹 (90163360)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
58. 本井ゆみ子 (60338407)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
59. 町田裕 (90317470)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
60. ANDRZEI Cichocki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
61. CICHOCKI Andrzej

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

MIZUNO Yoshikuni 水野 美邦

水野 義邦 ミズノ ヨシクニ

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パーキンソン病における神経細胞死の機序解明とその防御Principal Investigator

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MUTATIONAL ANALYSIS OF THE PARKIN GENE AND FUNCTIONAL ANALYSIS OF THE PARKIN PROTEINPrincipal Investigator

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MIZUNO Yoshikuni 水野美邦

水野義邦ミズノヨシクニ