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HATTORI Nobutaka  服部 信孝

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… Alternative Names

服部 信孝  ハットリ ノブタカ

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Researcher Number 80218510
Other IDs
External Links
Affiliation (Current) 2020: 順天堂大学, 医学(系)研究科(研究院), 教授
Affiliation (based on the past Project Information) *help 2015 – 2019: 順天堂大学, 医学(系)研究科(研究院), 教授
2006 – 2017: Juntendo Medical, Professor, School of Medicine, Professor
2016: 順天堂大学, 医学研究科, 教授
2016: 順天堂大学, 脳神経内科, 教授
2008: 順天堂大学, 医学部・神経内科, 教授 … More
2006: 順天堂大学, 医学部, 准教授
2002 – 2005: Juntendo University, Neurology, Associate Professor, 医学部, 助教授
1999 – 2002: 順天堂大学, 医学部, 講師
1996 – 1998: 順天堂大学, 医学部, 助手
1994: 順天堂大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Biological Sciences / Neurology / Neurology / Medium-sized Section 52:General internal medicine and related fields
Except Principal Investigator
Neurology / Biological Sciences / Neurology / Neurochemistry/Neuropharmacology / Rehabilitation science/Welfare engineering / Nerve anatomy/Neuropathology … More / Biological pharmacy / Nerve anatomy/Neuropathology / General internal medicine(including psychosomatic medicine) / Neurosurgery / Pathological medical chemistry Less
Keywords
Principal Investigator
パーキンソン病 / PINK1 / ミトコンドリア / Parkin / 遺伝性パーキンソン病 / DJ-1 / オートファジー / 家族性パーキンソン病 / 若年性パーキンソン病 / ATP13A2 … More / リソソーム / AR-JP / Ubiquitin-protein ligase / Lewy body / UbcH7 / Ubiquitin-proteasome pathway / ユビキチン・プロテアソーム系 / CDCrel-1 / parkin / Lewy小体 / 神経細胞死 / CHCHD2 / 14-3-3η / 複合体I / 24-kDa subunit / NDUFV2 / ユビキチン / Young onset Parkinson's disease / ユビキチンリガーゼ / パーキン蛋白 / 基質 / パエル受容体 / 糖化修飾α-シヌクレイン / ubiquitin ligase / Pael receptor / ER stress / ubiquitin-proteasome系 / 糖化修飾アルファシヌクレイン / 共通機構 / Mitophagy / 蛋白分解系 / 封入体 / タンパク分解 / GBA / タンパク質分解 / ドパミンキノン体 / Knock-down parkin / パーキン / α-シヌクレイン / Familial Parkinson's disease / PLA2G6 / 遺伝的素因 / 遺伝子多型 / 電子伝達系 / B22 / アミノ酸置換 / RLNG finger motif / ユビキチン様ドメイン / A-JP / 蛋白質分解 / 凝集体 / ubiquitin-proteasome Pathwa / AutoPhagy-lysosomal Pathway / stabilization / loss-of-function effects / ER / 新規原因遺伝子 / 劣性遺伝性パーキンソン病 / ミトコンドリア機能 / autophagy-lysosomal path& / ATP132 / ユビキチン化 / 常染色体劣性晩発性パーキンソン病 / 連鎖解析 / CCCP / 品質管理 / 学習能力 / モデルマウス / ミトファジー / MPTP / 呼吸能 / ミトコンドリア膜電位 / MEF / ATP / パーキンソン病(PD) / IRP2 / インスリン / TIRF / PINk1 / slip rod test / ドーパミントランスポーター / インスリン分泌 / シンタキシン1A依存症 / セプチン / アクチン / ドーパミン細胞 / タンパク質分解異常 / ドーパミン / レトロマー / VPS35 / 脳神経疾患 / 遺伝子 / RING finger motif / Young onset Parkinson7s disease / Pael receotor / Ubiquitin ligase / Parkin protein / Ubiquitin-proteasome system / Juvenile Parkinson's disease / substrate / o-glycosylatedα-synuclein / parkin遺伝子 / PINK1遺伝子 / DJ-1遺伝子 / リガーゼ活性 / パーキン遺伝子 / PDCD-2 / LMO-4 / Glup / ドーパ・ドパミンキノン / 発症機序 / ドパミン自動酸化 / ドパミンキノン / parkin gene / PINK1 gene / DJ-1 gene / dopainine quinone / ligase activities / 24-kDaサブユニット / ミトコンドリア機能低下 / ノックアウトマウス / 24-Daサブユニット / alpha-synuclein / duplication / アグリゾーム / LRRK2 / Parkinson's disease / ubiquitin-proteasome / mitochondrial dysfunction / Knock-out mice / 脂質代謝 / ＳＮＣＡ / レヴィ小体 / α-synuclein / 脂質組成 / 遺伝子解析 / 伝播形式 / Programmed cell death-1 / 制御性T細胞 / 腸脳連関 … More
Except Principal Investigator
パーキンソン病 / Parkin / PINK1 / LRRK2 / 家族性パーキンソン病 / 遺伝子 / DJ-1 / PARK6 / パーキン / Parkinson's disease / ミトコンドリア / 発症機序 / PARK2 / Tau / α-シヌクレイン / 酸化ストレス / lipid rafts / 脳梗塞 / α-Synuclein / Familial Parkinson's disease / PARK7 / 遺伝 / タウ / 進行性核上性麻痺 / 皮質基底核変性症 / alpha-synuclein / 遺伝子治療 / 14-3-3蛋白 / 認知症 / 変異 / SNCA / オートファジー / 脳深部刺激療法 / 視床下核 / HSP27 / ARJP / パーキン遺伝子 / 神経細胞死 / α-synuclein / SIAH / Synphilin-1 / ユビキチン / PINK1遺伝子 / DJ-1遺伝子 / parkin gene / PINK1 gene / DJ-1 gene / 脳神経疾患 / 神経科学 / 蛋白質 / 脳保護療法 / 遺伝性パーキンソン病 / リン酸化 / マイトファジー / 神経変性疾患 / 複合体I / ミトコンドリアDNA / FTDP-17 / L266V / P301L変異 / ハプロタイプ / 家族性パーキンソニズム / 多因子病 / SNP / 病患感受性遺伝子 / 薬剤副作用 / オーダーメイド医療 / マイクロサテライト / ゲノムワイド関連解析 / 疾患感受性遺伝子 / 免疫機序 / バーキン / parkin / 紀伊半島 / 筋萎縮性側索硬化症 / パーキンソン認知症複合 / アルツハイマー神経原線維変化 / TDP-43 / タウ蛋白 / タウオパチー / パーキンソン症候群 / グアム島 / 膜輸送 / パーキンソン病(PD) / 常染色体優性遺伝性パーキンソン病(ADPD) / 遺伝子変異 / 多型 / 常染色体優性遺伝 / 分子遺伝学 / パーキソンソ病 / 家族性パーキソンソ病 / ミトファジー / 嚥下障害 / 舌骨 / 嚥下造影検査 / 動作緩慢 / リハビリテ－ション / パ－キンソン病 / 舌骨運動 / リハビリテーション / 嚥下造影 / 舌骨動態 / 無動 / コエンザイムQ10 / ユビキノール / 酸化的ストレス / ウエアリングオフ / コエンザイムＱ10 / 還元型コエンザイムQ10 / サプリメント / 無作為化二重盲検併行群間試験 / 二重盲検法 / 大脳基底核 / 淡蒼球 / 線条体 / 介在ニューロン / 脳保護 / small heat shock protein / 一過性脳虚血再還流モデル / 遺伝的背景 / 遺伝子型 / MJD1 / 遺伝子多型 / Genetic Background / PSP / Genotype / アデノ随伴ウイルスベクター / 常染色体劣性遺伝若年性パーキンソン病 / AAV vector / Parkin gene / Gene therapy / パーキンソニズム / 遺伝子産物 / 神経細胞 / 分化 / 発達 / イムノブロッティング / 培養細胞 / 発現 / 脳 / Parkinson's Disease / Parkinsonism / Brain / Neuronal Cells / Immunoblotting / Development / Differentiation / ドパミンキノン / ドパミン自動酸化 / CDCrel-1 / シヌクレイン / Alpha-synulcein / Pathogenesis / synphilin-1 / ユビキチンリガーゼ / Lewy小体 / ユビキチン化 / Siah-1 / ドーパミン / ubiquitination / ubiquitin lipase / Lewy body / PARD7 / 連鎖解析 / neurological disorder / neuroscience / gene / protein / parkin遺伝子 / RNA編集 / 変異ユビキチン / プロテアソーム / RNA editing / Cerebral infarction / Mutant ubiquitin / Proteasome / Neuronal death / Neuroprotection / Lipid rafts / 細胞内局在 / ゴルジ体 / シナプス小胞 / Famililal Parkinson's disease / 脳梗塞急性期 / tPA / 血管内皮保護 / BBB / Heat Shock Protein 27 / 脳保護作用 / 血管内皮細胞 / 血液脳関門 / 出血性梗塞 / 活性型合成HSP27 / 改造学 / 解剖学 / 遺伝子重複 / びまん性レビー小体病 / DNA / 二倍体 / Gene chip / duplication / 重複 / SNCS / アルツハイマー病 / 皮質基底核症候群 / 進行性失語症 / ドパーミントランスポーターシンチグラフィ / 脳血流シンチ / 髄液マーカー / 意味性認知症 / 非流暢性失語 / レビー小体型認知症 / 局所フィールド電位 / 神経内科学 / ケミカルバイオロジー / 内科 / 脳・神経 / 創薬シーズ / リソソーム / 蛋白分解 / 小分子化合物 / mitophagy / ドーパミン神経 / iPS細胞 / CHCHD2 / iPS / ドパミン神経 / ショウジョウバエ / 遺伝学 / シグナル伝達 / 神経変性 / キナーゼ Less

  • Research Projects

    (49 results)

  • Research Products

    (582 results)

  • Co-Researchers

    (161 People)

  •  Pathogenesis role of programmed cell death-1 in Parkinson's disease mouse modelPrincipal InvestigatorOngoing

    • Principal Investigator
      服部 信孝
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 52:General internal medicine and related fields
    • Research Institution
      Juntendo University

  •  Elucidation of the mechanisms of the Parkinson's disease genes and Lewy Body formation and alpha-synuclein propagation mechanismsPrincipal InvestigatorOngoing

    • Principal Investigator
      服部 信孝
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 52:General internal medicine and related fields
    • Research Institution
      Juntendo University

  •  Analysis of lipid composition in hereditary Parkinson's Disease and the association with the pathologyPrincipal Investigator

    • Principal Investigator
      Hattori Nobutaka
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      Juntendo University

  •  Clinical Analysis of Neurodegenerative Dementia Using Cerebrospinal Fluid Biomarkers

    • Principal Investigator
      Yumiko Motoi
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General internal medicine(including psychosomatic medicine)
    • Research Institution
      Juntendo University

  •  Development of DBS programming based on local field potential analysis

    • Principal Investigator
      Umemura Atsushi
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurosurgery
    • Research Institution
      Juntendo University

  •  Elucidation of the mechanism of mitochondrial maintenance by Parkinson's disease gene products

    • Principal Investigator
      SHIBA Kahori
    • Project Period (FY)
      2014 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Juntendo University

  •  A study on the common pathogenesis of Parkinson's disease as a mitochondrial disease

    • Principal Investigator
      Imai Yuzuru
    • Project Period (FY)
      2014 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Juntendo University

  •  Phosphorylated recombinant HSP27 as a new neuroprotective agent for acute ischemic stroke

    • Principal Investigator
      TANAKA RYOTA
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      Juntendo University

  •  The detection of modifier gens in alpha-synuclein multiplications

    • Principal Investigator
      Nishioka Kenya
    • Project Period (FY)
      2013 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Neurology
    • Research Institution
      Juntendo University

  •  Development of autophagy enhancing chemicals based on Parkinson's disease pathogenesis.

    • Principal Investigator
      SAIKI Shinji
    • Project Period (FY)
      2013 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Juntendo University

  •  Autophagy lysosomal dysfunction associate with the pathogenesis of early onset Parkinson's disease.Principal Investigator

    • Principal Investigator
      HATTORI Nobutaka
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      Juntendo University

  •  Basic research to establish novel therapy for Parkinson disease using neuromodulation

    • Principal Investigator
      SHIMO Yasushi
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Juntendo University

  •  Development of the new cerebral infarction therapy by HSP27 protein

    • Principal Investigator
      SHIMURA Hideki
    • Project Period (FY)
      2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      Juntendo University

  •  オートファジー破綻におけるシナプス機能不全のメカニズムPrincipal Investigator

    • Principal Investigator
      服部 信孝
    • Project Period (FY)
      2011
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Juntendo University

  •  Mechanisms of the inclusion body formation in the brain: Association of an inclusion body and the neuronal cell deathPrincipal Investigator

    • Principal Investigator
      Hattori Nobutaka
    • Project Period (FY)
      2011 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Juntendo University

  •  Randomized, double-blind, placebo-controlled trial of reduced form of coenzyme Q10 of Parkinson's disease

    • Principal Investigator
      YORITAKA Asako
    • Project Period (FY)
      2011 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Juntendo University

  •  Brain Environment

    • Principal Investigator
      Takahashi Ryosuke
    • Project Period (FY)
      2011 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University

  •  The clinical investigation towards the rehabilitation effect on Parkinson's disease

    • Principal Investigator
      HATORI Kozo
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Rehabilitation science/Welfare engineering
    • Research Institution
      Juntendo University

  •  Generation of pathological models for Parkinson's diseasePrincipal Investigator

    • Principal Investigator
      HATTORI Nobutaka
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      Juntendo University

  •  Gnentic analysis to identify new causative genes in autosomal dominant Parkinson's disease

    • Principal Investigator
      TOMIYAMA Hiroyuki
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Juntendo University

  •  Effects of mitophagy on cell death in Parkinson's disease model cells

    • Principal Investigator
      SAIKI Shinji
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Neurology
    • Research Institution
      Juntendo University

  •  To elucidate the pathogenesis of Parkinson' s disease and to develop a new therapy for the diseasePrincipal Investigator

    • Principal Investigator
      HATTORI Nobutaka
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Juntendo University

  •  Analyses of responsible protein for familial Parkinson's disease in lipid rafts.

    • Principal Investigator
      KUBO Shinichiro
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Juntendo University

  •  パーキンソン病における蛋白分解系の関与Principal Investigator

    • Principal Investigator
      服部 信孝
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Juntendo University

  •  Molecular biological study on the cause and pathogenesis of amyotrophic lateral sclerosis and parkinsonism-dementia complex of the Kii peninsula of Japan

    • Principal Investigator
      KUZUHARA Shigeki
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      National Center of Neurology and Psychiatry
      Mie University

  •  Identification of a common pathway among gene products for familial Parkinson's disease and screening for a novel causative gene forPrincipal Investigator

    • Principal Investigator
      HATTORI Nobutaka
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      Juntendo University

  •  Functional analyses of the responsible proteins for familial Parkinson's disease in association with lipid rafts

    • Principal Investigator
      KUBO Shin-ichiro
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Juntendo University

  •  Search for Parkinson-related genes and their functional analysis

    • Principal Investigator
      TODA Tatsushi
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Osaka University

  •  パーキンソン病における神経細胞死の機序解明とその防御

    • Principal Investigator
      水野 美邦
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Juntendo University

  •  The analysis of Familial Parkinson's disease gene products and the research for identification of a novel Familial Parkinson's disease genePrincipal Investigator

    • Principal Investigator
      HATTORI Nobutaka
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      JUNTENDO UNIVERSITY

  •  Analysis on aggregation formation by novel Lewy body component Siah-1 complementary to Parkin

    • Principal Investigator
      TAKAHASHI Tetsuya, 山下 拓史
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Hiroshima University

  •  PINK1 gene and DJ-1 gene mutation analysis about juvenile Parkinson's disease.

    • Principal Investigator
      SATO Kenichi
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Juntendo University

  •  New therapy for cerebral infarction targeting of the control of mutant ubiquitin 1 (UBB+1) producted by RNA editing

    • Principal Investigator
      URABE Takao
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Juntendo University

  •  Mutational and functional analysis for Familial Parkinson's diseasePrincipal Investigator

    • Principal Investigator
      HATTORI Nobutaka
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      JUNTENDO UNIVERSITY

  •  IDENTIFICATION AND CHARACTERIZATION OF A NOVEL UBIQUITIN LIGASE SIAH THAT EXHIBITS COMPLEMENTARY ROLES WITH PARKIN

    • Principal Investigator
      YAMASHITA Hiroshi
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      HIROSHIMA UNIVERSITY

  •  Linkage analysis for novel gene cause of familial Parkinson's disease

    • Principal Investigator
      SATO Kenichi
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      JUNTENDO UNIVERSITY

  •  ユビキチンリガーゼとしてのパーキン蛋白の機能解析Principal Investigator

    • Principal Investigator
      服部 信孝
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Juntendo University

  •  パーキンソン病の遺伝的背景の解析

    • Principal Investigator
      小林 智則
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Juntendo University

  •  MUTATIONAL ANALYSIS OF THE PARKIN GENE AND FUNCTIONAL ANALYSIS OF THE PARKIN PROTEIN

    • Principal Investigator
      MIZUNO Yoshikuni
    • Project Period (FY)
      2001 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      JUNTENDO UNIVERSITY

  •  Mutation and functional analysis of parkin responsible for AR-JPPrincipal Investigator

    • Principal Investigator
      HATTORI Nobutaka
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      Juntendo University

  •  若年性パーキンソンニズム(AR-JP)の原因遺伝子産物パーキン蛋白質の機能解析及び遺伝子変異解析Principal Investigator

    • Principal Investigator
      服部 信孝
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Juntendo University

  •  パーキンソン病におけるユビキチン様蛋白質の意義Principal Investigator

    • Principal Investigator
      服部 信孝
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Juntendo University

  •  Reseach for Gene therapy of ARJP

    • Principal Investigator
      MOCHIZUKI Hideki
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Neurology
    • Research Institution
      JUNTENDO UNIVERSITY

  •  Mutational and functional analyses of the parkin responsible for AR-JPPrincipal Investigator

    • Principal Investigator
      HATTORI Nobutaka
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      JUNTENDO UNIVERSITY

  •  The Expression of Parkin as a Pathogenic Gene for Autosomal Recessive Juvenile Parkinsonism and Its Physiological Role

    • Principal Investigator
      HORI Takamitsu
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Setsunan University

  •  GENETIC BACKGROUND OF SPORADIC PARKINSON'S DISEASE

    • Principal Investigator
      KOBAYASHI Tomonori
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      JUNTENDO UNIVERSITY

  •  パーキンソン病の遺伝的素因に関する研究:ミトコンドリア電子伝達系複合体I24-kDa,51-kDa subunits遺伝子異常についてPrincipal Investigator

    • Principal Investigator
      服部 信孝
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Neurology
    • Research Institution
      Juntendo University

  •  パーキンソン病の遺伝的素因に関する研究Principal Investigator

    • Principal Investigator
      服部 信孝
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Neurology
    • Research Institution
      Juntendo University

  •  パーキンソン病におけるミトコンドリア蛋白遺伝子異常

    • Principal Investigator
      MIZUNO Yoshikuni
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Juntendo University

All 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 Other

All Journal Article Presentation Book Patent

  • [Book] パーキンソン病診療総論、神経内科 Clinical Questions & Pearls パーキンソン病2019
    • Author(s)
      鈴木則宏、服部信孝、下泰司、波田野琢、王子悠、濃沼崇博、岩室宏一、他
    • Total Pages
      335
    • Publisher
      中外医学社
    • ISBN
      9784498328044
    • Data Source
      KAKENHI-PROJECT-18H04043

  • [Book] 最新版　順天堂大学が教えるパーキンソン病の自宅療法2018
    • Author(s)
      服部信孝
    • Total Pages
      208
    • Publisher
      主婦の友社
    • ISBN
      9784074342600
    • Data Source
      KAKENHI-PROJECT-18H04043

  • [Book] パーキンソン病診療ガイドライン20182018
    • Author(s)
      日本神経学会 (編集委員長：服部信孝)
    • Total Pages
      288
    • Publisher
      医学書院
    • ISBN
      9784260035965
    • Data Source
      KAKENHI-PROJECT-18H04043

  • [Book] Mitophagy, Methods and Protocols, Methods in Molecular Biology 1759,2018
    • Author(s)
      Hattori N, Saiki S.: Editors, John M. Walker: Series Editor
    • Total Pages
      180
    • Publisher
      Humana Press
    • ISBN
      9781493977499
    • Data Source
      KAKENHI-PROJECT-18H04043

  • [Book] Methods Mol Biol.2017
    • Author(s)
      Imai Y, Inoshita T, Shiba-Fukushima K, Meng H, Hattori N
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-26293070

  • [Book] 遺伝子から探るバーキンソン病病態へのミトコンドリアの関与、ミ卜コンドリア研究 UPDATE、医学のあゆみ2017
    • Author(s)
      今居　譲、柴佳保里、服部信孝．
    • Publisher
      医歯薬出版株式会社、東京
    • Data Source
      KAKENHI-PROJECT-15H04842

  • [Book] 遺伝子から探るバーキンソン病病態へのミトコンドリアの関与、ミ卜コンドリア研究 UPDATE、医学のあゆみ2017
    • Author(s)
      今居　譲、柴佳保里、服部信孝
    • Total Pages
      1030
    • Publisher
      医歯薬出版株式会社、東京
    • Data Source
      KAKENHI-PROJECT-15H04842

  • [Book] 【パーキンソン病の新展開-発症の分子機構と新規治療】 分子機構解明の新しい展開 PARK9(ATP13A2)モデル動物の解析と病態2017
    • Author(s)
      佐藤 栄人、服部 信孝
    • Total Pages
      1386
    • Publisher
      医学のあゆみ、東京
    • Data Source
      KAKENHI-PROJECT-15H04842

  • [Book] Methods in Molecular Biology, Mitophagy2017
    • Author(s)
      Shinji Saiki, Nobutaka Hattori
    • Total Pages
      200
    • Publisher
      Splinger
    • Data Source
      KAKENHI-PLANNED-25111007

  • [Book] ATP13A2, 脳内環境辞典2017
    • Author(s)
      佐藤栄人、服部信孝
    • Total Pages
      156
    • Publisher
      メディカル ドゥ、大阪
    • Data Source
      KAKENHI-PROJECT-15H04842

  • [Book] パーキンソン病外来2016
    • Author(s)
      大山彦光，下泰司，梅村淳，服部信孝
    • Total Pages
      264
    • Publisher
      Medical View
    • Data Source
      KAKENHI-PROJECT-26462219

  • [Book] 7．大脳変性疾患、II　錐体外路系疾患、1～9、臨床神経内科学、第6版1刷　監修；平山惠造、編集；廣瀬源二郎、田代邦雄、葛原茂樹2016
    • Author(s)
      服部信孝
    • Publisher
      南山堂、東京
    • Data Source
      KAKENHI-PLANNED-23111003

  • [Book] 第17番染色体に連鎖するパーキソニズムを伴う前側頭葉型認知症（FTDP-17）2016
    • Author(s)
      西岡健弥，池田彩，服部信孝
    • Publisher
      中外医学社
    • Data Source
      KAKENHI-PROJECT-25860726

  • [Book] ７．大脳変性疾患、II　錐体外路系疾患、1～9、臨床神経内科学　（監修；平山惠造、編集；廣瀬源二郎、田代邦雄、葛原茂樹)2016
    • Author(s)
      服部信孝
    • Publisher
      南山堂、東京
    • Data Source
      KAKENHI-PROJECT-15H04842

  • [Book] 家族性パーキンソン病　update annual review 20162016
    • Author(s)
      松島隆史、西岡健弥、服部信孝
    • Publisher
      中外医学社
    • Data Source
      KAKENHI-PROJECT-25860726

  • [Book] 実験医学2015
    • Author(s)
      今居　譲、柴佳保里、服部信孝
    • Total Pages
      134
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-26461280

  • [Book] パーキンソン病・アルツハイマー型認知症、コエンザイムQ10の基礎と応用2015
    • Author(s)
      頼高朝子、服部信孝．
    • Publisher
      編者：日本コエンザイムQ協会、発行所：丸善プラネット㈱、発売所：丸善出版（株）
    • Data Source
      KAKENHI-PLANNED-23111003

  • [Book] 痛みのScience and Practice2015
    • Author(s)
      西岡健弥　服部信孝
    • Publisher
      文光堂
    • Data Source
      KAKENHI-PROJECT-25860726

  • [Book] 12番染色体に連鎖する遺伝性パーキンソン病（PARK8）、III変性疾患、錐体外路系疾患・パーキンソニズムを主とする疾患、家族性パーキンソン病　優性遺伝性パーキンソン症候群、別冊　日本臨床　新領域別症候群シリーズ No.27、神経症候群（第2版）（II）2014
    • Author(s)
      富山弘幸、服部信孝
    • Total Pages
      5
    • Publisher
      日本臨床社、大阪
    • Data Source
      KAKENHI-PLANNED-23111003

  • [Book] 6番染色体に連鎖する遺伝性パーキンソン病（PARK2）、Ⅲ変性疾患、錐体外路系疾患・パーキンソニズムを主とする疾患、家族性パーキンソン病　優性遺伝性パーキンソン症候群、別冊　日本臨床　新領域別症候群シリーズ No.27、神経症候群（第2版）（Ⅱ）　－その他の神経疾患を含めて－2014
    • Author(s)
      西岡健弥、服部信孝
    • Total Pages
      903
    • Publisher
      日本臨床社
    • Data Source
      KAKENHI-PLANNED-23111003

  • [Book] 1番染色体に連鎖する遺伝性パーキンソン病（PARK6, PARK7, PARK9(Kufor-Rakeb症候群), PARK10, PARK16）、III変性疾患、錐体外路系疾患・パーキンソニズムを主とする疾患、家族性パーキンソン病　優性遺伝性パーキンソン症候群、別冊　日本臨床　新領域別症候群シリーズ No.27、神経症候群（第2版）（II）2014
    • Author(s)
      波田野琢、服部信孝
    • Total Pages
      6
    • Publisher
      日本臨床社、大阪
    • Data Source
      KAKENHI-PROJECT-24390224

  • [Book] 04抗パーキンソン病薬、治療薬ハンドブック2014　薬剤選択と処方のポイント（監修：高久史麿、編集：堀正二、他）2014
    • Author(s)
      服部信孝
    • Total Pages
      5
    • Publisher
      株式会社　じほう
    • Data Source
      KAKENHI-PLANNED-23111003

  • [Book] 16番染色体に連鎖する遺伝性パーキンソン病（PARK17）､III変性疾患、錐体外路系疾患・パーキンソニズムを主とする疾患、家族性パーキンソン病　優性遺伝性パーキンソン症候群、別冊　日本臨床　新領域別症候群シリーズ No.27、神経症候群（第2版）（II）2014
    • Author(s)
      舩山　学、安藤真矢、服部信孝．
    • Total Pages
      4
    • Publisher
      日本臨床社、大阪
    • Data Source
      KAKENHI-PLANNED-23111003

  • [Book] 6番染色体に連鎖する遺伝性パーキンソン病（PARK2）、III変性疾患、錐体外路系疾患・パーキンソニズムを主とする疾患、家族性パーキンソン病　優性遺伝性パーキンソン症候群、別冊　日本臨床　新領域別症候群シリーズ No.27、神経症候群（第2版）（II）2014
    • Author(s)
      西岡健弥、服部信孝．
    • Total Pages
      5
    • Publisher
      日本臨床社、大阪
    • Data Source
      KAKENHI-PLANNED-23111003

  • [Book] 04抗パーキンソン病薬、治療薬ハンドブック2014　薬剤選択と処方のポイント（監修：高久史麿、編集：堀正二、他）2014
    • Author(s)
      服部信孝
    • Total Pages
      5
    • Publisher
      株式会社　じほう
    • Data Source
      KAKENHI-PROJECT-24390224

  • [Book] 日本臨床　新領域別症候群シリーズ No.27、神経症候群（第2版）（Ⅱ）　－その他の神経疾患を含めて－、12番染色体に連鎖する遺伝性パーキンソン病（PARK8）、Ⅲ変性疾患、錐体外路系疾患・パーキンソニズムを主とする疾患、家族性パーキンソン病　優性遺伝性パーキンソン症候群2014
    • Author(s)
      富山弘幸、服部信孝
    • Total Pages
      903
    • Publisher
      日本臨床社
    • Data Source
      KAKENHI-PROJECT-24390224

  • [Book] 16番染色体に連鎖する遺伝性パーキンソン病（PARK17）､Ⅲ変性疾患、錐体外路系疾患・パーキンソニズムを主とする疾患、家族性パーキンソン病　優性遺伝性パーキンソン症候群、別冊　日本臨床　新領域別症候群シリーズ No.27、神経症候群（第2版）（Ⅱ）　－その他の神経疾患を含めて－2014
    • Author(s)
      舩山　学、安藤真矢、服部信孝
    • Total Pages
      903
    • Publisher
      日本臨床社
    • Data Source
      KAKENHI-PROJECT-24390224

  • [Book] 1番染色体に連鎖する遺伝性パーキンソン病（PARK6, PARK7, PARK9(Kufor-Rakeb症候群), PARK10, PARK16）、Ⅲ変性疾患、錐体外路系疾患・パーキンソニズムを主とする疾患、家族性パーキンソン病　優性遺伝性パーキンソン症候群、別冊　日本臨床　新領域別症候群シリーズ No.27、神経症候群（第2版）（Ⅱ）　－その他の神経疾患を含めて－2014
    • Author(s)
      波田野琢、服部信孝
    • Total Pages
      903
    • Publisher
      日本臨床社
    • Data Source
      KAKENHI-PLANNED-23111003

  • [Book] 16番染色体に連鎖する遺伝性パーキンソン病（PARK17）､Ⅲ変性疾患、錐体外路系疾患・パーキンソニズムを主とする疾患、家族性パーキンソン病　優性遺伝性パーキンソン症候群、別冊　日本臨床　新領域別症候群シリーズ No.27、神経症候群（第2版）（Ⅱ）　－その他の神経疾患を含めて－2014
    • Author(s)
      舩山　学、安藤真矢、服部信孝
    • Total Pages
      903
    • Publisher
      日本臨床社
    • Data Source
      KAKENHI-PLANNED-23111003

  • [Book] 16番染色体に連鎖する遺伝性パーキンソン病（PARK17）､III変性疾患、錐体外路系疾患・パーキンソニズムを主とする疾患、家族性パーキンソン病　優性遺伝性パーキンソン症候群、別冊　日本臨床　新領域別症候群シリーズ No.27、神経症候群（第2版）（II）2014
    • Author(s)
      舩山　学、安藤真矢、服部信孝．
    • Total Pages
      4
    • Publisher
      日本臨床社、大阪
    • Data Source
      KAKENHI-PROJECT-24390224

  • [Book] 神経症候群（第２版）（II）ーその他の神経疾患を含めてー2014
    • Author(s)
      西岡健弥　服部信孝
    • Publisher
      日本臨床社
    • Data Source
      KAKENHI-PROJECT-25860726

  • [Book] 6番染色体に連鎖する遺伝性パーキンソン病（PARK2）、Ⅲ変性疾患、錐体外路系疾患・パーキンソニズムを主とする疾患、家族性パーキンソン病　優性遺伝性パーキンソン症候群、別冊　日本臨床　新領域別症候群シリーズ No.27、神経症候群（第2版）（Ⅱ）　－その他の神経疾患を含めて－2014
    • Author(s)
      西岡健弥、服部信孝
    • Total Pages
      903
    • Publisher
      日本臨床社
    • Data Source
      KAKENHI-PROJECT-24390224

  • [Book] 1番染色体に連鎖する遺伝性パーキンソン病（PARK6, PARK7, PARK9(Kufor-Rakeb症候群), PARK10, PARK16）、Ⅲ変性疾患、錐体外路系疾患・パーキンソニズムを主とする疾患、家族性パーキンソン病　優性遺伝性パーキンソン症候群、別冊　日本臨床　新領域別症候群シリーズ No.27、神経症候群（第2版）（Ⅱ）　－その他の神経疾患を含めて－、2014
    • Author(s)
      波田野琢、服部信孝
    • Total Pages
      903
    • Publisher
      日本臨床社
    • Data Source
      KAKENHI-PROJECT-24390224

  • [Book] 遺伝子医学MOOK(1349-2527)26号, 【脳内環境-維持機構と破綻がもたらす疾患研究】 (第1章)神経細胞内病態と脳内環境　パーキンソン病における封入体形成のメカニズムと細胞死の関連性について2014
    • Author(s)
      佐藤 栄人, 服部 信孝
    • Total Pages
      220
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-24390224

  • [Book] 6番染色体に連鎖する遺伝性パーキンソン病（PARK2）、III変性疾患、錐体外路系疾患・パーキンソニズムを主とする疾患、家族性パーキンソン病　優性遺伝性パーキンソン症候群、別冊　日本臨床　新領域別症候群シリーズ No.27、神経症候群（第2版）（II）2014
    • Author(s)
      西岡健弥、服部信孝．
    • Total Pages
      5
    • Publisher
      日本臨床社、大阪
    • Data Source
      KAKENHI-PROJECT-24390224

  • [Book] 12番染色体に連鎖する遺伝性パーキンソン病（PARK8）、III変性疾患、錐体外路系疾患・パーキンソニズムを主とする疾患、家族性パーキンソン病　優性遺伝性パーキンソン症候群、別冊　日本臨床　新領域別症候群シリーズ No.27、神経症候群（第2版）（II）2014
    • Author(s)
      富山弘幸、服部信孝
    • Total Pages
      5
    • Publisher
      日本臨床社、大阪
    • Data Source
      KAKENHI-PROJECT-24390224

  • [Book] 12番染色体に連鎖する遺伝性パーキンソン病（PARK8）、Ⅲ変性疾患、錐体外路系疾患・パーキンソニズムを主とする疾患、家族性パーキンソン病　優性遺伝性パーキンソン症候群、別冊　日本臨床　新領域別症候群シリーズ No.27、神経症候群（第2版）（Ⅱ）　－その他の神経疾患を含めて－2014
    • Author(s)
      富山弘幸、服部信孝．
    • Total Pages
      903
    • Publisher
      日本臨床社
    • Data Source
      KAKENHI-PLANNED-23111003

  • [Book] 1番染色体に連鎖する遺伝性パーキンソン病（PARK6, PARK7, PARK9(Kufor-Rakeb症候群), PARK10, PARK16）、III変性疾患、錐体外路系疾患・パーキンソニズムを主とする疾患、家族性パーキンソン病　優性遺伝性パーキンソン症候群、別冊　日本臨床　新領域別症候群シリーズ No.27、神経症候群（第2版）（II）2014
    • Author(s)
      波田野琢、服部信孝
    • Total Pages
      6
    • Publisher
      日本臨床社、大阪
    • Data Source
      KAKENHI-PLANNED-23111003

  • [Book] GPレジデントのためのパーキンソン病テキストブック(山本光利 編)一第一部パーキンソン病の基本的知識- パーキンソン病の遺伝学と遺伝子診断の手順2012
    • Author(s)
      服部信孝
    • Total Pages
      248
    • Publisher
      アルタ出版
    • Data Source
      KAKENHI-PROJECT-24390224

  • [Book] GPレジデントのためのパーキンソン病テキストブック2012
    • Author(s)
      服部信孝
    • Total Pages
      11
    • Publisher
      アルタ出版
    • Data Source
      KAKENHI-PLANNED-23111003

  • [Book] PARK 2 : Parkin Mutations Responsible for Familial Prakinson's Disease. Movement Disorders 42010
    • Author(s)
      Hattori N, Hatano T, Machida Y, Sato S, Kubo S
    • Data Source
      KAKENHI-PROJECT-21390272

  • [Book] Blue Books of Neurology, Movement Disorders 4 : Parkin Mutations Responsible for Familial Parkinson's Disease2010
    • Author(s)
      Hattori N, Hatano T, Machida Y, Sato S, Kubo S
    • Publisher
      SAUNDERS ELSEVIER
    • Data Source
      KAKENHI-PROJECT-21390272

  • [Book] いきなり名医!パーキンソン病Q&A.2009
    • Author(s)
      服部信孝
    • Total Pages
      145
    • Publisher
      日本医事新報社
    • Data Source
      KAKENHI-PROJECT-20023028

  • [Book] いきなり名医!パーキンソン病Q&A2009
    • Author(s)
      服部信孝
    • Total Pages
      145
    • Publisher
      日本医事新報社
    • Data Source
      KAKENHI-PROJECT-20023028

  • [Book] ここまでわかったパーキンソン病研究2008
    • Author(s)
      服部 信孝
    • Total Pages
      466
    • Publisher
      医師薬出版
    • Data Source
      KAKENHI-PROJECT-19390244

  • [Book] 高齢者パーキンソン病の治療戦略(座談会)2008
    • Author(s)
      服部信孝
    • Publisher
      Pharma Medica
    • Data Source
      KAKENHI-PROJECT-19390244

  • [Book] ここまでわかったパーキンソン病研究2008
    • Author(s)
      服部信孝
    • Total Pages
      466
    • Publisher
      医師薬出版
    • Data Source
      KAKENHI-PROJECT-20023028

  • [Book] 薬学セレクト疾患と薬物治療知っておきたいcommon diseases101(富野康日己・望月正隆編)2008
    • Author(s)
      服部信孝
    • Publisher
      医歯薬出版
    • Data Source
      KAKENHI-PROJECT-19390244

  • [Book] ここまでわかったパーキンソン病研究2008
    • Author(s)
      服部信孝
    • Total Pages
      466
    • Publisher
      医師薬出版
    • Data Source
      KAKENHI-PROJECT-19044040

  • [Book] パーキンソン病患者さんに発生する合併症の諸問題と具体的対応策2008
    • Author(s)
      名取司保子・服部信孝
    • Publisher
      難病と在宅ケア
    • Data Source
      KAKENHI-PROJECT-19390244

  • [Book] 基本治療薬115使い方と禁忌 富野 康日己 編 三環系抗うつ薬<服部信孝>塩酸アミトリプチリン トリプタノール(Trypanol), 67脳血栓症急性期およびクモ膜下出血治療薬<服部信孝>オザグレルナトリウム カタクロット(Cataclot), キサンボン(Xanbon)2007
    • Author(s)
      服部 信孝
    • Total Pages
      451
    • Publisher
      中外医学者
    • Data Source
      KAKENHI-PROJECT-19390244

  • [Book] Elsevier2007
    • Author(s)
      Mizuno, Y・Hattori, N・Mochiduki, H・Koller, W・Melamed, E.
    • Publisher
      Genetic Aspects of Parkinson's Disease. In Handbook of Clinical Neurology, eds
    • Data Source
      KAKENHI-PROJECT-17025037

  • [Book] 基本治療薬115使い方と禁忌 富野 康日己 編 三環系抗うつ薬 <服部信孝>塩酸アミトリプチリン トリプタノール(Tryptanol), 67脳血栓症急性期およびクモ膜下出血治療薬 <服部信孝> オザグレルナトリウム カタクロット(Cataclot), キサンボン (Xanbon)2007
    • Author(s)
      服部信孝
    • Total Pages
      451
    • Publisher
      中外医学者
    • Data Source
      KAKENHI-PROJECT-19044040

  • [Book] 基本治療薬115使い方と禁忌三環系抗うつ薬<服部信孝>塩酸アミトリプチリン トリプタノール(Tryptanol), 67脳血栓症急性期およびクモ膜下出血治療薬<服部信孝>オザグレルナトリウム カタクロット(Cataclot)(富野康日己編)2007
    • Author(s)
      服部信孝
    • Data Source
      KAKENHI-PROJECT-19390244

  • [Book] 脳神経疾患病態の分子生物学2005
    • Author(s)
      服部 信孝, 柴香保里
    • Total Pages
      191
    • Publisher
      南山堂
    • Data Source
      KAKENHI-PROJECT-17390256

  • [Book] Molecular Mechanism in Parkinson's disease : Do familial Parkinson's disease genes share a common pathway involved in the nigral degeneration?(Edited by Phillip Kahle and Christian Haass)2004
    • Author(s)
      Hattori N, Mizuno Y, et al.
    • Publisher
      Eurekah com, Germany(In press)
    • Data Source
      KAKENHI-PROJECT-15390277

  • [Book] Nature Encyclopedia of the Human Genome2003
    • Author(s)
      Hattori N, Mizuno Y
    • Total Pages
      4000
    • Publisher
      Nature publishing group
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390277

  • [Journal Article] Twin CHCH Proteins, CHCHD2, and CHCHD10: Key Molecules of Parkinson’s Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia.2019
    • Author(s)
      Imai Yuzuru、Meng Hongrui、Shiba-Fukushima Kahori、Hattori Nobutaka
    • Journal Title

      Int J Mol Sci.

      Volume: 20 Pages: 908-908

    • DOI

      10.3390/ijms20040908

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K15465, KAKENHI-PROJECT-18H04043, KAKENHI-PROJECT-17H04049, KAKENHI-PROJECT-16K19525

  • [Journal Article] Loss of nuclear REST/NRSF in aged-dopaminergic neurons in Parkinson’s disease patients2019
    • Author(s)
      Kawamura Miwako、Sato Shigeto、Matsumoto Gen、Fukuda Takahiro、Shiba-Fukushima Kahori、Noda Sachiko、Takanashi Masashi、Mori Nozomu、Hattori Nobutaka
    • Journal Title

      Neuroscience Letters

      Volume: 699 Pages: 59-63

    • DOI

      10.1016/j.neulet.2019.01.042

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K07111, KAKENHI-PROJECT-18H04043

  • [Journal Article] Metabolomics-based identification of metabolic alterations in PARK22019
    • Author(s)
      Okuzumi Ayami、Hatano Taku、Ueno Shin‐Ichi、Ogawa Takashi、Saiki Shinji、Mori Akio、Koinuma Takahiro、Oji Yutaka、Ishikawa Kei‐Ichi、Fujimaki Motoki、Sato Shigeto、Ramamoorthy Sivapriya、Mohney Robert P.、Hattori Nobutaka
    • Journal Title

      Ann Clin Transl Neurol.

      Volume: 6 Pages: 525-536

    • DOI

      10.1002/acn3.724

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K07797, KAKENHI-PROJECT-18H04043, KAKENHI-PROJECT-16K09675

  • [Journal Article] Clinical heterogeneity of FTDP-17 caused by MAPT N279K mutation in relation to tau PET features.2019
    • Author(s)
      Ikeda Aya、Shimada Hitoshi、Nishioka Kenya、Takanashi Masashi、Hayashida Arisa、Li Yuanzhe、Yoshino Hiroyo、Funayama Manabu、Ueno Yuji、Hatano Taku、Sahara Naruhiko、Suhara Tetsuya、Higuchi Makoto、Hattori Nobutaka
    • Journal Title

      Movement Disorders.

      Volume: 34 Pages: 568-574

    • DOI

      10.1002/mds.27623

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-26117008, KAKENHI-PROJECT-18H04043, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-16K09675, KAKENHI-PROJECT-16K09676, KAKENHI-PROJECT-16K09678, KAKENHI-PROJECT-16K09700

  • [Journal Article] Rapid dissemination of alpha-synuclein seeds through neural circuits in an in-vivo prion-like seeding experiment2018
    • Author(s)
      Okuzumi, A., Kurosawa, M., Hatano, T., Takanashi, M., Nojiri, S., Fukuhara, T., Yamanaka, T., Miyazaki, H., Yoshinaga, S., Furukawa, Y., Shimogori, T., Hattori, N., Nukina, N.
    • Journal Title

      Acta Neuropathol Commun

      Volume: 6 Pages: 96-96

    • DOI

      10.1186/s40478-018-0587-0

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17KT0131, KAKENHI-PUBLICLY-17H05705, KAKENHI-PUBLICLY-18H04564, KAKENHI-PROJECT-17H01564, KAKENHI-PROJECT-18H04043, KAKENHI-PROJECT-16H04768, KAKENHI-PROJECT-18H02723, KAKENHI-PROJECT-15K06762, KAKENHI-PROJECT-16K09675, KAKENHI-PROJECT-18H00446

  • [Journal Article] Syntaxin 17 regulates the localization and function of PGAM5 in mitochondrial division and mitophagy.2018
    • Author(s)
      Sugo Masashi、Kimura Hana、Arasaki Kohei、Amemiya Toshiki、Hirota Naohiko、Dohmae Naoshi、Imai Yuzuru、Inoshita Tsuyoshi、Shiba‐Fukushima Kahori、Hattori Nobutaka、Cheng Jinglei、Fujimoto Toyoshi、Wakana Yuichi、Inoue Hiroki、Tagaya Mitsuo
    • Journal Title

      EMBO J.

      Volume: 37

    • DOI

      10.15252/embj.201798899

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06138, KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05902, KAKENHI-PROJECT-18H04023, KAKENHI-PROJECT-18H04043, KAKENHI-PROJECT-17H04049, KAKENHI-PROJECT-18H02439, KAKENHI-PROJECT-18H02656

  • [Journal Article] Regulation of membrane dynamics by Parkinson's disease-associated genes. Review.2018
    • Author(s)
      Inoshita T, Cui C, Hattori N, Imai Y.
    • Journal Title

      J Genet.

      Volume: 97 Pages: 715-725

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18H04043

  • [Journal Article] Dopaminergic Neuron-Specific Autophagy-Deficient Mice2018
    • Author(s)
      Sato S, Hattori N.
    • Journal Title

      Methods Mol Biol.

      Volume: 1759 Pages: 173-175

    • DOI

      10.1007/7651_2018_156

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18H04043

  • [Journal Article] Zonisamide Administration Improves Fatty Acid β-Oxidation in Parkinson’s Disease2018
    • Author(s)
      Ueno SI, Saiki S, Fujimaki M, Takeshige-Amano H, Hatano T, Oyama G, Ishikawa KI, Yamguchi A, Nojiri S, Akamatsu W, Hattori N.
    • Journal Title

      Cells

      Volume: 8 Pages: 14-14

    • DOI

      10.3390/cells8010014

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18KT0027, KAKENHI-PROJECT-17K07797, KAKENHI-PROJECT-18K15463, KAKENHI-PUBLICLY-17H05706, KAKENHI-PROJECT-18H04043, KAKENHI-PROJECT-18H02744, KAKENHI-PROJECT-16K09675, KAKENHI-PROJECT-16K09677

  • [Journal Article] Loss of autophagy in dopaminergic neurons causes Lewy pathology and motor dysfunction in aged mice.2018
    • Author(s)
      Sato, S., Uchihara, T., Fukuda, T., Noda, S., Kondo, H., Saiki, S., Komatsu, M., Uchiyama, Y., Tanaka, K., and Hattori, N.
    • Journal Title

      Sci. Rep.

      Volume: ８ Pages: 2813-2813

    • DOI

      10.1038/s41598-018-21325-w

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K06780, KAKENHI-PROJECT-17K07797, KAKENHI-PROJECT-16K14572, KAKENHI-PLANNED-25111006, KAKENHI-PLANNED-25111007, KAKENHI-PROJECT-15H04842, KAKENHI-PROJECT-15H04843, KAKENHI-PROJECT-17H03555, KAKENHI-PROJECT-26000014, KAKENHI-PROJECT-18H04043

  • [Journal Article] Serum caffeine and metabolites are reliable biomarkers of early Parkinson's disease.2018
    • Author(s)
      Fujimaki M, Saiki S, Li Y, Kaga N, Taka H, Hatano T, Ishikawa KI, Oji Y, Mori A, Okuzumi A, Koinuma T, Ueno SI, Imamichi Y, Ueno T, Miura Y, Funayama M, Hattori N.
    • Journal Title

      Neurology

      Volume: 90 Pages: 404-411

    • DOI

      10.1212/wnl.0000000000004888

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K01834, KAKENHI-PROJECT-16K09675, KAKENHI-PROJECT-16K09676, KAKENHI-PROJECT-17K07797, KAKENHI-PROJECT-15KK0354, KAKENHI-PROJECT-18K07829, KAKENHI-PROJECT-18H04043, KAKENHI-PROJECT-16K09700

  • [Journal Article] Interleaving stimulation with a combination of bipolar and monopolar configurations for secondary failure of bilateral subthalamic stimulation in Parkinson’s disease.2017
    • Author(s)
      Tsukada R, Oyama G, Shimo Y, Sekimoto S, Jo T, Nakajima A, Umemura A, Arai H, Hattori N
    • Journal Title

      Neurol Clin Neurosci

      Volume: 5 Pages: 32-33

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26462219

  • [Journal Article] Evidence that phosphorylated ubiquitin signaling is involved in the etiology of Parkinson's disease.2017
    • Author(s)
      Shiba-Fukushima Kahori、Ishikawa Kei-Ichi、Inoshita Tsuyoshi、Izawa Nana、Takanashi Masashi、Sato Shigeto、Onodera Osamu、Akamatsu Wado、Okano Hideyuki、Imai Yuzuru、Hattori Nobutaka
    • Journal Title

      Hum Mol Genet

      Volume: 26 Pages: 3172-3185

    • DOI

      10.1093/hmg/ddx201

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09677, KAKENHI-PROJECT-17K09765, KAKENHI-PROJECT-26293070, KAKENHI-PROJECT-15H04842, KAKENHI-PROJECT-26461280, KAKENHI-PROJECT-16K15484, KAKENHI-PROJECT-16K19524

  • [Journal Article] Genotype-phenotype correlations of cysteine replacement in CADASIL.2017
    • Author(s)
      Matsushima, Takashi; Conedera, Silvio; Tanaka, Ryota; Li, Yuanzhe; Yoshino, Hiroyo; Funayama, Manabu; Ikeda, Aya; Hosaka, Yuka; Okuzumi, Ayame; Shimada, Yoshiaki; Yamashiro, Kazuo; Motoi, Yumiko; Nishioka, Kenya; Hattori, Nobutaka
    • Journal Title

      Neurobiology of Aging

      Volume: 50

    • DOI

      10.1016/j.neurobiolaging.2016.10.026

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H04842, KAKENHI-PROJECT-25860726, KAKENHI-PROJECT-16K09678

  • [Journal Article] Reduced TDP-43 Expression Improves Neuronal Activities in a Drosophila Model of Perry Syndrome2017
    • Author(s)
      Hosaka Y, Inoshita T, Shiba-Fukushima K, Cui C, Arano T, Imai Y, Hattori N
    • Journal Title

      EBioMedicine

      Volume: 21 Pages: 218-227

    • DOI

      10.1016/j.ebiom.2017.06.002

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26293070

  • [Journal Article] Loss of Parkinson's disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c2017
    • Author(s)
      Meng H, Yamashita C, Shiba-Fukushima K, Inoshita T, Funayama M, Sato S, Hatta T, Natsume T, Umitsu M, Takagi J, Imai Y, Hattori N.
    • Journal Title

      Nature Commun

      Volume: 8 Pages: 15500-15500

    • DOI

      10.1038/ncomms15500

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09676, KAKENHI-PROJECT-16K19525, KAKENHI-PROJECT-26293070, KAKENHI-PROJECT-15H04842, KAKENHI-PROJECT-15KK0354, KAKENHI-PROJECT-17H01420

  • [Journal Article] [Deep Brain Stimulation for Parkinson Disease:Mechanisms and New Technology].2017
    • Author(s)
      梅村淳，下泰司，岩室宏一，大山彦光，服部信孝，新井一
    • Journal Title

      No Shinkei Geka.

      Volume: 45 Pages: 5-14

    • Data Source
      KAKENHI-PROJECT-26462219, KAKENHI-PROJECT-15K19498

  • [Journal Article] 進行期パーキンソン病の治療　手術療法2017
    • Author(s)
      梅村淳，大山彦光，下泰司，服部信孝
    • Journal Title

      日本臨床

      Volume: 75 Pages: 83-88

    • Data Source
      KAKENHI-PROJECT-26462219

  • [Journal Article] Decreased long-chain acylcarnitines from insufficient β-oxidation as potential early diagnostic markers for Parkinson’s disease2017
    • Author(s)
      Saiki S, Hatano T, Fujimaki M, Ishikawa K, Mori A, Oji Y, Okuzumi A, Fukuhara T, Koinuma T, Nagumo M, Furuya N, Nojiri S, Amo T, Yamashiro K, Hattori N.
    • Journal Title

      Scientific Reports

      Volume: 7 Pages: 7328-7328

    • DOI

      10.1038/s41598-017-06767-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09675, KAKENHI-PROJECT-17K07797, KAKENHI-PROJECT-17K09769, KAKENHI-PLANNED-25111007, KAKENHI-PROJECT-15H04843, KAKENHI-PROJECT-15K09325

  • [Journal Article] 遺伝子から探るパーキンソン病病態へのミトコンドリアの関与2017
    • Author(s)
      今居　譲、柴佳保里、服部信孝
    • Journal Title

      医学のあゆみ

      Volume: 260 Pages: 85-91

    • Data Source
      KAKENHI-PROJECT-26293070

  • [Journal Article] A novel mutation of CHCHD2 p.R8H in a sporadic case of Parkinson's disease.2017
    • Author(s)
      Ikeda, Aya; Matsushima, Takashi; Daida, Kensuke; Nakajima, Sho; Conedera, Silvio; Li, Yuanzhe; Yoshino, Hiroyo; Oyama, Genko; Funayama, Manabu; Nishioka, Kenya; Hattori, Nobutaka
    • Journal Title

      Parkinsonism and Related Diosorders

      Volume: 34 Pages: 66-68

    • DOI

      10.1016/j.parkreldis.2016.10.018

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H04842, KAKENHI-PROJECT-25860726, KAKENHI-PROJECT-16K09678, KAKENHI-PROJECT-16K09700, KAKENHI-PROJECT-15K19498, KAKENHI-PROJECT-16K09676, KAKENHI-PROJECT-15KK0354

  • [Journal Article] Age-related effects and gender differences in Japanese healthy controls for [123I] FP-CIT SPECT.2017
    • Author(s)
      Hideo Yamamoto, Shinichi Arimura, Atsushi Nakanishi, Yasushi Shimo, Yumiko Motoi, Koichi Ishiguro, Koji Murakami, Nobutaka Hattori, Shigeki Aoki
    • Journal Title

      Ann Nucl Med.

      Volume: 未定 Pages: 407-412

    • DOI

      10.1007/s12149-017-1168-1

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26460921, KAKENHI-PROJECT-26461869

  • [Journal Article] Lysosomal defects in ATP13A2 and GBA associated familial Parkinson's disease2017
    • Author(s)
      Sato S, Li Y, Hattori N.
    • Journal Title

      J Neural Transm (Vienna)

      Volume: 124 Pages: 1395-1400

    • DOI

      10.1007/s00702-017-1779-7

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09700, KAKENHI-PROJECT-15H04842

  • [Journal Article] Lysosomal Storage of Subunit c of Mitochondrial ATP Synthase in Brain-Specific Atp13a2-Deficient Mice.2016
    • Author(s)
      Sato, S., Koike, M., Funayama, M., Ezaki, J., Fukuda, T., Ueno, T., Uchiyama, Y., Hattori, N
    • Journal Title

      The American Journal of Pathology

      Volume: 186 Pages: 3074-3082

    • DOI

      10.1016/j.ajpath.2016.08.006

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-15H01388, KAKENHI-PROJECT-15H04842, KAKENHI-PROJECT-16K09676, KAKENHI-PROJECT-15KK0354

  • [Journal Article] Effect of zonisamide on post-traumatic Holmes’ tremor2016
    • Author(s)
      Sekimoto S, Oyama G, Izawa N, Ueno S, Jo T, Shimo Y, Nakajima A, Nakajima M, Umemura A, Arai H, Hattori N
    • Journal Title

      Neurology and Clinical Neuroscience

      Volume: 4 Pages: 184-185

    • DOI

      10.1111/ncn3.12063

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26462219, KAKENHI-PROJECT-15K19498

  • [Journal Article] Identification of novel biomarkers for Parkinson’s disease by metabolomic technologies.2016
    • Author(s)
      Hatano T, Saiki S, Okuzumi A, Mohney RP, Hattori N.
    • Journal Title

      Jouranal of Neurology, Neurosurgery, Psychiatry

      Volume: jnnp-2014 Pages: 295-301

    • DOI

      10.1136/jnnp-2014-309676

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PLANNED-23111003, KAKENHI-PROJECT-24390224, KAKENHI-ORGANIZER-25111001, KAKENHI-PROJECT-25461290, KAKENHI-PLANNED-25111007

  • [Journal Article] FBXO7 Mutations in Parkinson's Disease and Multiple System Atrophy.2016
    • Author(s)
      Conedera S, Apaydin H, Li Y, et al.
    • Journal Title

      Neurobiology of Aging

      Volume: 40

    • DOI

      10.1016/j.neurobiolaging.2016.01.003

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25860726, KAKENHI-PLANNED-23111003, KAKENHI-PROJECT-25461291, KAKENHI-PROJECT-25860725, KAKENHI-PROJECT-16K09676, KAKENHI-PROJECT-16K09678, KAKENHI-PROJECT-15KK0354

  • [Journal Article] Genetic association between presenilin 2 polymorphisms and Alzheimer’s disease and dementia of Lewy body type in a Japanese population.2016
    • Author(s)
      Suzuki A, Shibata N, Kasanuki K, et al.
    • Journal Title

      Dementia and Geriatric Cognitive Disorders Extra

      Volume: 16 Pages: 90-97

    • DOI

      10.1159/000444080

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25860726, KAKENHI-PROJECT-26860946, KAKENHI-PROJECT-16K09678

  • [Journal Article] Current Topics in Deep Brain Stimulation for Parkinson Disease2016
    • Author(s)
      Umemura A, Oyama G, Shimo Y, Nakajima M, Nakajima A, Jo T, Sekimoto S, Ito M, Mitsuhashi T, Hattori N, Arai H
    • Journal Title

      Neurologia medico-chirurgica

      Volume: 56 Issue: 10 Pages: 613-625

    • DOI

      10.2176/nmc.ra.2016-0021

    • NAID

      130005429955

    • ISSN
      0470-8105, 1349-8029
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26462219

  • [Journal Article] Movement disorders: advances in 2015.2016
    • Author(s)
      Hattori N.
    • Journal Title

      Lancet Neurol.

      Volume: 15 Pages: 8-9

    • DOI

      10.1016/s1474-4422(15)00362-2

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-23111003, KAKENHI-PROJECT-15H04842

  • [Journal Article] Genetic association between RAGE polymorphisms and Alzheimer's disease and Lewy body dementias in a Japanese cohort: a case-control study.2016
    • Author(s)
      Takeshita Y, Shibata N, Kasanuki K, Nagata T, Shinagawa S, Kobayashi N, Ohnuma T, Suzuki A, Kawai E, Takayama T, Nishioka K, Motoi Y, Hattori N, Nakayama K, Yamada H, Arai H.
    • Journal Title

      International journal of geriatric psychiatry

      Volume: 4

    • DOI

      10.1002/gps.4600

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25860726, KAKENHI-PROJECT-16K09678, KAKENHI-PROJECT-26860946

  • [Journal Article] Schizoohrenia as a prodromal symptom in a patient harbouring SNCA duplication.2016
    • Author(s)
      Takamura S, Ikeda A, Nishioka K, Furuya H, Tashiro M, Matsushima T, Li Y, Yoshino H, Funayama M, Morinobu S, Hattori N.
    • Journal Title

      Parkinsonism Relat Didorder

      Volume: S1353-8020 Pages: 30028-1

    • DOI

      10.1016/j.parkreldis.2016.01.028

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-23111003, KAKENHI-PROJECT-25461291, KAKENHI-PROJECT-25860725, KAKENHI-PROJECT-25860726, KAKENHI-PROJECT-16K09676, KAKENHI-PROJECT-16K09678, KAKENHI-PROJECT-26461311, KAKENHI-PROJECT-15KK0354

  • [Journal Article] Functional neurons generated from T cell-derived iPSCs for neurological disease modeling.2016
    • Author(s)
      Matsumoto T, Fujimori K, Andoh-Noda T, Ando T, Kuzumaki N, Toyoshima M, Tada H, Imaizumi K, Ishikawa M, Yamaguchi R, Isoda M, Zhou Z, Sato S, Kobayashi T, Ohtaka M, Nishimura K, Kurosawa H, Yoshikawa T, Takahashi T, Nakanishi M, Ohyama M, Hattori N, Akamatsu W, Okano H.
    • Journal Title

      STEM CELL REPORTS

      Volume: 6 Pages: 422-35

    • DOI

      10.1016/j.stemcr.2016.01.010

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K06780, KAKENHI-PROJECT-15K09849, KAKENHI-PROJECT-15K15041, KAKENHI-PROJECT-26830018, KAKENHI-PLANNED-23111003, KAKENHI-PLANNED-24116002, KAKENHI-PROJECT-15H04842, KAKENHI-PROJECT-26870074, KAKENHI-ORGANIZER-24116001, KAKENHI-PROJECT-16K08280

  • [Journal Article] Genome-wide analyses in neuronal cells reveal that upstream transcription factors regulate lysosomal gene expression2016
    • Author(s)
      Yamada D, Saiki S, Furuya N, Ishikawa K, Imamichi Y, Kambe T, Fujimura T, Ueno T, Koike M, Sumiyoshi K, Hattori N
    • Journal Title

      FEBS JOURNAL

      Volume: 471 Pages: 1077-1087

    • DOI

      10.1016/j.bbrc.2016.01.171

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09325, KAKENHI-PUBLICLY-15H01388, KAKENHI-PLANNED-23111003, KAKENHI-PUBLICLY-26111519, KAKENHI-PROJECT-15H04501, KAKENHI-PROJECT-15H04843, KAKENHI-PROJECT-26893263, KAKENHI-PROJECT-25460276, KAKENHI-PROJECT-26660086, KAKENHI-PLANNED-25111007, KAKENHI-PROJECT-15H04842

  • [Journal Article] Randomized, double-blind, placebo-controlled pilot trial of reduced coenzyme Q10 for Parkinson’s disease2015
    • Author(s)
      Asako Yoritaka, Sumihiro Kawajiri, Yorihiro Yamamoto,Toshiki Nakahara, P, Maya Ando, Kazuhiko Hashimoto, Midori Nagase, Yufuko Saito, Nobutaka Hattori
    • Journal Title

      Parkinsonism & Related Disorders

      Volume: 未定

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-23591282

  • [Journal Article] Anterior opercular syndrome induced by Epstein-Barr virus encephalitis.2015
    • Author(s)
      Matsushima T, Nishioka K, Tanaka R, Yokoyama K, Hattori N.
    • Journal Title

      Neurocase

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25860726

  • [Journal Article] Current Topics「PINK1とParkinが紡ぐリン酸化ポリユビキチンの鎖が、Parkinをミトコンドリアへと局在化させる」2015
    • Author(s)
      今居　譲、柴佳保里、服部信孝
    • Journal Title

      実験医学

      Volume: 33 Pages: 940-943

    • Data Source
      KAKENHI-PROJECT-26293070

  • [Journal Article] Variants associated with Gaucher disease in multiple system atrophy2015
    • Author(s)
      Mitsui J, Matsukawa T, Sasaki H, Yabe I, Nakahara Y, Momose Y, Takahashi Y, Hara K, Kakita A, Yamada M, Takahashi H, Onodera O, Nishizawa M, Watanabe H, Nakashima K, Ito H, Izumi Y, Kaji R, Kato T, Tsuji S, et al.
    • Journal Title

      Annals of Clinical and Translational Neurology

      Volume: 2 Pages: 417-26

    • DOI

      10.1002/acn3.185

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24591248, KAKENHI-PROJECT-24591252, KAKENHI-PUBLICLY-25110720, KAKENHI-PUBLICLY-25129703, KAKENHI-PROJECT-25670420, KAKENHI-PROJECT-25860700, KAKENHI-PROJECT-26461311, KAKENHI-PROJECT-26461319, KAKENHI-PROJECT-15K09334, KAKENHI-PROJECT-26461303, KAKENHI-PROJECT-221S0002, KAKENHI-PROJECT-15H04842, KAKENHI-PROJECT-25461313, KAKENHI-PROJECT-25713015, KAKENHI-PLANNED-26117002, KAKENHI-ORGANIZER-26117001

  • [Journal Article] VPS29-VPS35 intermediate of retromer is stable and may be involved in the retromer complex assembly process2015
    • Author(s)
      Fuse A, Furuya N, Kakuta S, Inose A, Sato M, Koike M, Saiki S, Hattori N
    • Journal Title

      FEBS Lett

      Volume: 589 Pages: 1430-1436

    • DOI

      10.1016/j.febslet.2015.04.040

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09325, KAKENHI-PUBLICLY-15H01388, KAKENHI-PLANNED-23111003, KAKENHI-PLANNED-25111007, KAKENHI-PUBLICLY-26111519, KAKENHI-PROJECT-15H04843, KAKENHI-PROJECT-25460276

  • [Journal Article] Generation and characterization of novel conformation-specific monoclonal antibodies for α-synuclein pathology.2015
    • Author(s)
      Vaikath NN, Majbour NK, Paleologou KE, Ardah MT, van Dam E, van de Berg WD, Forrest SL, Parkkinen L, Gai WP, Hattori N, Takanashi M, Lee SJ, Mann DM, Imai Y, Halliday GM, Li JY, El-Agnaf OM.
    • Journal Title

      Neurobiol Dis

      Volume: 79 Pages: 81-99

    • DOI

      10.1016/j.nbd.2015.04.009

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-23111003, KAKENHI-PROJECT-15H04842, KAKENHI-PROJECT-26293070

  • [Journal Article] Mitochondrial targeting sequence variants of the CHCHD2 gene are a risk for Lewy body disorders.2015
    • Author(s)
      Ogaki K, Koga S, Heckman MG, et al.
    • Journal Title

      Neurology.

      Volume: 85 Pages: 2016-2025

    • DOI

      10.1212/wnl.0000000000002170

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25860726, KAKENHI-PLANNED-23111003, KAKENHI-PROJECT-15H04842, KAKENHI-PROJECT-25461291

  • [Journal Article] Identification of a gene associated with autosomal dominant late-onset Parkinson's disease: a genome-wide linkage and sequencing study2015
    • Author(s)
      Funayama M, Ohe K, Amo T, Furuya N, Yamaguchi J, Saiki S, Yuanzhe L, Ogaki K, Ando M, Yoshinon H, Tomiyama H, Nishioka K, Hasegawa K, Saiki H, Satake W, Mogushi K, Sasaki R, Kokubo Y, Kuzuhara S, Toda T, Mizuno Y, Uchiyama Y, Ohno K, Hattori N.
    • Journal Title

      The Lancet Neurology

      Volume: 14 Pages: 274-282

    • DOI

      10.1016/s1474-4422(14)70266-2

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-22129006, KAKENHI-PROJECT-24390224, KAKENHI-PROJECT-24500868, KAKENHI-PROJECT-24790903, KAKENHI-PUBLICLY-25110720, KAKENHI-ORGANIZER-25111001, KAKENHI-PLANNED-25111007, KAKENHI-PUBLICLY-25129707, KAKENHI-PROJECT-25461291, KAKENHI-PROJECT-25461292, KAKENHI-PROJECT-25670420, KAKENHI-PROJECT-25713015, KAKENHI-PROJECT-25860726, KAKENHI-PROJECT-26253057, KAKENHI-PROJECT-26870175, KAKENHI-PROJECT-15K10050, KAKENHI-ORGANIZER-23111001, KAKENHI-PLANNED-23111003, KAKENHI-PLANNED-23111004, KAKENHI-PROJECT-25257507, KAKENHI-PROJECT-15H04842, KAKENHI-PROJECT-25860725, KAKENHI-PROJECT-25305030

  • [Journal Article] PARK2/Parkin-mediated mitochondrial clearance contributes to proteasome activation during slow-twitch muscle atrophy via NFE2L1 nuclear translocation2015
    • Author(s)
      Furuya N, Ikeda SI, Sato S, Soma S, Ezaki J, Trejo JA, Takeda-Ezaki M, Fujimura T, Arikawa-Hirasawa E, Tada N, Komatsu M, Tanaka K, Kominami E, Ueno T.
    • Journal Title

      Physiological Reports

      Volume: 10 Pages: 631-41

    • DOI

      10.4161/auto.27785

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PLANNED-23111003, KAKENHI-PROJECT-23592350, KAKENHI-PROJECT-24390224, KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-25350901, KAKENHI-PROJECT-25670426, KAKENHI-PROJECT-26000014

  • [Journal Article] Iron induces mitochondrial damage that recruits parkin2015
    • Author(s)
      Rubio ME, Fukazawa Y, Kamasawa N, Clarkson C, Molnar E, Shigemoto R
    • Journal Title

      Neuroscience Letter

      Volume: 588 Pages: 29-35

    • DOI

      10.1016/j.neulet.2014.12.052

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-221S0003, KAKENHI-PLANNED-23111003, KAKENHI-PLANNED-24108008, KAKENHI-PROJECT-24390224, KAKENHI-PROJECT-24659431, KAKENHI-PUBLICLY-25129707, KAKENHI-PROJECT-25460276, KAKENHI-PROJECT-25461290, KAKENHI-PROJECT-25461291, KAKENHI-PROJECT-25860711, KAKENHI-PUBLICLY-26111519, KAKENHI-PROJECT-25461279, KAKENHI-PROJECT-26860188

  • [Journal Article] ABCG2 variant has opposing effects on ages at onset of Parkinson’s disease and gout.2015
    • Author(s)
      Matsuo H, Tomiyama H, Satake W, Chiba T, Onoue H, Kawamura Y, Nakayama A, ShimizuS, Sakiyama M, Funayama M, Nishioka K, Shimizu T, Kaida K, Kamakura K, Toda T, Hattori N, ShinomiyaN.
    • Journal Title

      Annals of Clinical and Translational Neurology

      Volume: 2 Pages: 302-306

    • DOI

      10.1002/acn3.167

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-22129006, KAKENHI-PLANNED-23111003, KAKENHI-PROJECT-24390224, KAKENHI-PUBLICLY-25110720, KAKENHI-PUBLICLY-25129707, KAKENHI-PROJECT-25293145, KAKENHI-PROJECT-25461291, KAKENHI-PROJECT-25461292, KAKENHI-PROJECT-25670307, KAKENHI-PROJECT-25670420, KAKENHI-PROJECT-26253057, KAKENHI-PROJECT-25860726, KAKENHI-PROJECT-15H04315, KAKENHI-PROJECT-25713015

  • [Journal Article] Five-year outcomes of bilateral subthalamic nucleus stimulation in Japanese patients with Parkinson’s disease.2015
    • Author(s)
      Umemura A, Miyata M, Oka Y, Okita K, Oyama G, Shimo Y, Hattori N
    • Journal Title

      Advance in Parkinson’s Disease

      Volume: 4 Pages: 21-27

    • DOI

      10.4236/apd.2015.42004

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26462219

  • [Journal Article] Lipid rafts involvement in the pathogenesis of Parkinson's disease.2015
    • Author(s)
      Kubo S, Hatano T, Hattori N.
    • Journal Title

      Front Biosci (Landmark Ed).

      Volume: 20 Pages: 263-79

    • Data Source
      KAKENHI-PROJECT-24390224

  • [Journal Article] パーキンソン病の薬物治療、DBS手術適応、術後のケア2015
    • Author(s)
      梅村淳，大山彦光，下泰司，服部信孝
    • Journal Title

      脳神経外科速報

      Volume: 25 Pages: 294-302

    • Data Source
      KAKENHI-PROJECT-26462219

  • [Journal Article] High frequency of beta-propeller protein-associated neurodegeneration (BPAN) among patients with intellectual disability and young onset parkinsonism.2015
    • Author(s)
      Nishioka K, Oyama G, Yoshino H, Li Y, Matsushima T, Takeuchi C, Mochizuki Y, Mori-Yoshimura M, Murata M, Yamasita C, Nakamura N, Konishi Y, Ohi K, Ichikawa K, Terada T, Obi T, Funayama M, Saiki S, Hattori N.
    • Journal Title

      Neurobiology of aging

      Volume: S0197 Pages: 54-58

    • DOI

      10.1016/j.neurobiolaging.2015.01.020

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PLANNED-23111003, KAKENHI-PROJECT-24390224, KAKENHI-ORGANIZER-25111001, KAKENHI-PLANNED-25111007, KAKENHI-PUBLICLY-25129707, KAKENHI-PROJECT-25461291, KAKENHI-PROJECT-25860726, KAKENHI-PROJECT-15K19498, KAKENHI-PROJECT-15H04842, KAKENHI-PROJECT-25860725

  • [Journal Article] The Parkinson's Disease-Associated Protein 　　Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway.2015
    • Author(s)
      Imai Y, Kobayashi Y, Inoshita T, Meng H, Arano T, Uemura K, Asano T, Yoshimi K, Zhang CL, Matsumoto G, Ohtsuka T, Kageyama R, Kiyonari H, Shioi G, Nukina N, Hattori N, Takahashi R
    • Journal Title

      PLoS Genet

      Volume: 11

    • DOI

      10.1371/journal.pgen.1005503

    • NAID

      120005946994

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K06773, KAKENHI-PROJECT-26860219, KAKENHI-PUBLICLY-15H01561, KAKENHI-PLANNED-23111003, KAKENHI-PROJECT-15H02540, KAKENHI-PROJECT-15H04842, KAKENHI-PROJECT-26670442, KAKENHI-PLANNED-23111002

  • [Journal Article] 進化するパーキンソン病治療　手術療法2014
    • Author(s)
      梅村淳，大山彦光，下泰司，服部信孝
    • Journal Title

      Progress in Medicine

      Volume: 34 Pages: 265-269

    • Data Source
      KAKENHI-PROJECT-26462219

  • [Journal Article] Parkin regulates kainate receptors by interacting with the GluK2 subunit.2014
    • Author(s)
      Maraschi A, Ciammola A, Folci A, Sassone F, Ronzitti G, Cappelletti G, Silani V, Sato S, Hattori N, Mazzanti M, Chieregatti E, Mulle C, Passafaro M, Sassone J.
    • Journal Title

      Nat Commun.

      Volume: 5 Pages: 5182-5182

    • DOI

      10.1038/ncomms6182

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-23111003, KAKENHI-PROJECT-24390224

  • [Journal Article] REST as a new therapeutic target for neurodegenerative disorders.2014
    • Author(s)
      Hattori N
    • Journal Title

      Mov Disord.

      Volume: 29 Pages: 869-869

    • DOI

      10.1002/mds.25910

    • Data Source
      KAKENHI-PLANNED-23111003

  • [Journal Article] The evaluation of polyglutamine repeats in autosomal dominant Parkinson's disease2014
    • Author(s)
      Yamashita C, Tomiyama H, Funayama M, Inamizu S, Ando M, Li Y, Yoshino H, Araki T, Ichikawa T, Ehara Y, Ishikawa K, Mizusawa H, Hattori N.
    • Journal Title

      Neurobiology of aging

      Volume: 35

    • DOI

      10.1016/j.neurobiolaging.2014.01.022

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-23111003, KAKENHI-PROJECT-24390224, KAKENHI-PROJECT-24591252, KAKENHI-PUBLICLY-25129703, KAKENHI-PUBLICLY-25129707, KAKENHI-PROJECT-25461291, KAKENHI-PROJECT-25461292, KAKENHI-PROJECT-25860725

  • [Journal Article] Lysine 63-linked polyubiquitination is dispensable for Parkin-mediated mitophagy.2014
    • Author(s)
      Shiba-Fukushima K, Inoshita T, Hattori N, Imai Y.
    • Journal Title

      J Biol. Chem.

      Volume: 289 Pages: 33131-33136

    • DOI

      10.1074/jbc.c114.580944

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-23111003, KAKENHI-PROJECT-24390224, KAKENHI-PUBLICLY-26117727, KAKENHI-PROJECT-26293070, KAKENHI-PROJECT-26461280

  • [Journal Article] Phosphorylatioon enhances recombinant HSP27 neuroprotectioin against focal cerebral ischemia in mice2014
    • Author(s)
      Yoshiaki Shimada, Ryota Tanaka, Hideki Shimura, Kazuo Yamshiro, Takao Urabe, Nobutaka Hattori
    • Journal Title

      Neuroscience

      Volume: 278 Pages: 113-121

    • DOI

      10.1016/j.neuroscience.2014.07.073

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24500423, KAKENHI-PROJECT-25430053

  • [Journal Article] Regulation by mitophagy.2014
    • Author(s)
      Hattori N, Saiki S, Imai Y.
    • Journal Title

      Int J Biochem Cell Biol

      Volume: 53 Pages: 147-150

    • DOI

      10.1016/j.biocel.2014.05.012

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-23111003, KAKENHI-PROJECT-24390224, KAKENHI-PLANNED-25111007, KAKENHI-PUBLICLY-26117727, KAKENHI-PROJECT-26293070

  • [Journal Article] PINK1-Mediated Phosphorylation of Parkin Boosts Parkin Activity in Drosophila2014
    • Author(s)
      Shiba-Fukushima K, Inoshita T, Hattori N, Imai Y.
    • Journal Title

      PLOS Genetics

      Volume: Jun 5;10(6) Pages: 1004391-1004391

    • DOI

      10.1371/journal.pgen.1004391

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-23111003, KAKENHI-PROJECT-24390224, KAKENHI-PUBLICLY-26117727, KAKENHI-PROJECT-26293070, KAKENHI-PROJECT-26461280, KAKENHI-PROJECT-26860219

  • [Journal Article] p150glued-associated disorders are caused by activation of intrinsic apoptotic pathway2014
    • Author(s)
      Ishikawa K, Saiki S, Furuya N, Yamada D, Imamichi Y, Li Y, Kawajiri S, Sasaki H, Koike M, Tsuboi Y, Hattori N.
    • Journal Title

      Plos One

      Volume: 9

    • DOI

      10.1371/journal.pone.0094645

    • NAID

      40020259609

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-23111003, KAKENHI-PROJECT-24390224, KAKENHI-ORGANIZER-25111001, KAKENHI-PLANNED-25111007, KAKENHI-PROJECT-25460276, KAKENHI-PROJECT-25860725, KAKENHI-PUBLICLY-26111519

  • [Journal Article] Clinicogenetic study of GBA mutations in patients with familial Parkinson's disease2014
    • Author(s)
      Li Y, Sekine T, Funayama M, Li L, Yoshino H, Nishioka K, Tomiyama H, Hattori N
    • Journal Title

      Neurobiology of aging

      Volume: 35

    • DOI

      10.1016/j.neurobiolaging.2013.09.019

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24390224, KAKENHI-PUBLICLY-25129707, KAKENHI-PROJECT-25461291, KAKENHI-PROJECT-25461292, KAKENHI-PROJECT-25860725, KAKENHI-PROJECT-25860726

  • [Journal Article] EIF4G1 gene mutations are not common pathogenic factor of Parkinson disease in Japanese population.2014
    • Author(s)
      Nishioka K, Funayama M, Vilarino-GuellC, Ogaki K, Li Y, Sasaki R, Kokubo Y, Kuzuhara S, Kachergus JM, Cobb SA, Takahashi H, Mizuno Y, Farrer MJ, Ross OA, Hattori N
    • Journal Title

      Parkinsonism and related disorders

      Volume: 20 Pages: 659-61

    • DOI

      10.1016/j.parkreldis.2014.03.004

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PLANNED-23111003, KAKENHI-PROJECT-24390224, KAKENHI-PUBLICLY-25129707, KAKENHI-PROJECT-25257507, KAKENHI-PROJECT-25461291, KAKENHI-PROJECT-25860725, KAKENHI-PROJECT-25860726

  • [Journal Article] Detailed analysis of mitochondrial respiratory chain defects caused by loss of PINK1.2014
    • Author(s)
      Amo T, Saiki S, Sawayama T, Sato S, Hattori N.
    • Journal Title

      Neuroscience Letters

      Volume: 580 Pages: 37-40

    • DOI

      10.1016/j.neulet.2014.07.045

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PLANNED-23111003, KAKENHI-PROJECT-24390224, KAKENHI-PROJECT-24790903

  • [Journal Article] Quantitative evaluation of electroconvulsive therapy for Parkinson's disease with refractory psychiatric symptoms.2014
    • Author(s)
      Nishioka K, Tanaka R, Shimura H, Hirano K, Hatano T, Miyakawa K, Arai H, Hattori N, Urabe T.
    • Journal Title

      Journal of Neural Transmission

      Volume: 121 Pages: 1405-1410

    • DOI

      10.1007/s00702-014-1212-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25461290, KAKENHI-PROJECT-25860726

  • [Journal Article] Identification of a Japanese family with LRRK2 p.R1441G-related Parkinson’s disease.2014
    • Author(s)
      Hatano T, Funayama M, Kubo S, Mata IF, Oji Y, Mori A, Zabetian CP, Waldherr SM, Yoshino H, Oyama G, Shimo Y, Fujimoto K, Oshima H, Kunii Y, Yabe H, Mizuno Y, Hattori N.
    • Journal Title

      Neurobiology of Aging

      Volume: Nov;35(11)

    • DOI

      10.1016/j.neurobiolaging.2014.05.025

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PLANNED-23111003, KAKENHI-PROJECT-24390224, KAKENHI-PUBLICLY-25129707, KAKENHI-PROJECT-25461290, KAKENHI-PROJECT-25461291

  • [Journal Article] Phosphorylation of Mitochondrial Polyubiquitin by PINK1 Promotes Parkin Mitochondrial Tethering2014
    • Author(s)
      Shiba-Fukushima K, Arano T, Matsumoto G, Inoshita T, Yoshida S, Ishihama Y, Ryu KY, Nukina N, Hattori N, Imai Y.
    • Journal Title

      PLOS Genetics

      Volume: 10 Pages: 1004861-1004861

    • DOI

      10.1371/journal.pgen.1004861

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-23111003, KAKENHI-PROJECT-23500434, KAKENHI-PROJECT-24241062, KAKENHI-PROJECT-24390224, KAKENHI-PUBLICLY-26117727, KAKENHI-PROJECT-26293070, KAKENHI-PROJECT-26461280, KAKENHI-PROJECT-26860219

  • [Journal Article] ATP13A2 Deficiency Induces a Decrease in Cathepsin D Activity, Fingerprint-like Inclusion, and Selective Degeneration of Dopaminergic Neurons2013
    • Author(s)
      Matsui H, Sato F, Sato S, Koike M, Taruno Y, Saiki S, Funayama M, Ito H, Taniguchi Y, Uemura N, Toyoda A, Sakaki Y, Takeda S, Uchiyama Y, Hattori N, Takahashi R.
    • Journal Title

      FEBS Letters

      Volume: 587(9) Pages: 1316-1325

    • DOI

      10.1016/j.febslet.2013.02.046

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-ORGANIZER-23111001, KAKENHI-PLANNED-23111002, KAKENHI-PLANNED-23111003, KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-23590244, KAKENHI-PROJECT-23689046, KAKENHI-PROJECT-23790238, KAKENHI-PROJECT-24300132, KAKENHI-PROJECT-24390224, KAKENHI-PROJECT-24659435, KAKENHI-PUBLICLY-25129707, KAKENHI-PROJECT-25461291, KAKENHI-PUBLICLY-23129506

  • [Journal Article] Chronic overload of SEPT4, a parkin substrate that aggregates in Parkinson's disease, causes behavioral alterations but not neurodegeneration in mice.2013
    • Author(s)
      Ageta-Ishihara N, Yamakado H, Morita T, Hattori S, Takao K, Miyakawa T, Takahashi R, Kinoshita M
    • Journal Title

      Molecular brain

      Volume: 6 Pages: 35-35

    • DOI

      10.1186/1756-6606-6-35

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-ORGANIZER-23111001, KAKENHI-PROJECT-23370084, KAKENHI-PROJECT-23390232, KAKENHI-PUBLICLY-24111546, KAKENHI-PROJECT-24770184, KAKENHI-PROJECT-24790879, KAKENHI-PUBLICLY-25116526, KAKENHI-PROJECT-25350989

  • [Journal Article] Subthalamic Deep Brain Stimulation for a Parkinson's Disease Patient With Duplication of SNCA.2013
    • Author(s)
      Shimo Y, Natori S, Oyama G, Nakajima M, Arai H, Ishii H, Hattori N
    • Journal Title

      Neuromodulation

      Volume: 16

    • DOI

      10.1111/ner.12034

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591304

  • [Journal Article] Tricornered/NDR kinase signaling mediates PINK1-directed mitochondrial quality control and tissue maintenance.2013
    • Author(s)
      Wu Z, Sawada T, Shiba K, Liu S, Kanao T, Takahashi R, Hattori N, Imai Y, Lu B. .
    • Journal Title

      Genes & Developments

      Volume: 27 Pages: 157-162

    • DOI

      10.1101/gad.203406.112

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-23111003, KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-23790973, KAKENHI-PROJECT-24790896

  • [Journal Article] Mitochondrial membrane potential decrease caused by loss of PINK1 is not due to proton leak, but to respiratory chain defects.2011
    • Author(s)
      Amo T, Sato S, Saiki S, Wolf AM, Toyomizu M, Gautier CA, Shen J, Ohta S, Hattori N.
    • Journal Title

      Neurobiology of Diseases

      Volume: 41 Pages: 111-118

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790853

  • [Journal Article] Genetic Epidemiology Of Parkinson's Disease(GEO-PD) Consortium. Association of LRRK2 exonic variants with susceptibility to Parkinson's disease : a case-control study2011
    • Author(s)
      Ross OA, Soto-Ortolaza AI, Heckman MG, Aasly JO, Abahuni N, Annesi G, Bacon JA, Bardien S, Bozi M, Brice A, Brighina L, Van Broeckhoven C, Carr J, Chartier-Harlin MC, Dardiotis E, Dickson DW, Diehl NN, Elbaz A, Ferrarese C, Ferraris A, Fiske B, Gibson JM,Gibson R, Hadjigeorgiou GM, Hattori N, Ioannidis JP, Jasinska-Myga B, Jeon BS, Kim YJ, Klein C, Kruger R, Kyratzi E, Lesage S, Lin CH, Lynch T, Maraganore DM, Mellick GD, Mutez E, Nilsson C, Opala G, Park SS, Puschmann A, Quattrone A, Sharma M, Silburn PA, Sohn YH, Stefanis L, Tadic V, Theuns J, Tomiyama H, Uitti RJ, Valente EM, van de Loo S, Vassilatis DK, Vilarino-Guell C, White LR, Wirdefeldt K, Wszolek ZK, Wu RM, Farrer MJ
    • Journal Title

      Lancet Neurol

      Volume: 10(10) Pages: 898-908

    • Data Source
      KAKENHI-PROJECT-21390272

  • [Journal Article] PLA2G6 variant in Parkinson's disease2011
    • Author(s)
      Tomiyama H, Yoshino H, Ogaki K, Li L, Yamashita C, Li Y, Funayama M, Sasaki R, Kokubo Y, Kuzuhara S, Hattori N
    • Journal Title

      J Hum Genet

      Volume: 56(5) Pages: 401-3

    • NAID

      10030659472

    • Data Source
      KAKENHI-PUBLICLY-23110518

  • [Journal Article] Genetic Epidemiology of Parkinson's Disease Consortium. Role of sepiapterin reductase gene at the PARK3 locus in Parkinson's disease2011
    • Author(s)
      Sharma M, Maraganore DM, Ioannidis JP, Riess O, Aasly JO, Annesi G, Abahuni N, Bentivoglio AR, Brice A, Van Broeckhoven C, Chartier-Harlin MC, Destee A, Djarmati A, Elbaz A, Farrer M, Ferrarese C, Gibson JM, Gispert S, Hattori N, Jasinska-Myga B, Klein C, Lesage S, Lynch T, Lichtner P, Lambert JC, Lang AE, Mellick GD, Nigris FD, Opala G, Quattrone A, Riva C, Rogaeva E, Ross OA, Satake W, Silburn PA, Theuns J, Toda T, Tomiyama H, Uitti RJ, Wirdefeldt K, Wszolek Z, Gasser T, Kruger R
    • Journal Title

      Neurobiol Aging

      Volume: 32

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591098

  • [Journal Article] Genetic mutations and mitochondrial toxins shed new light on the pathogenesis of Parkinson's disease2011
    • Author(s)
      Sato S, Hattori N
    • Journal Title

      Parkinsons Dis

      Volume: 2011 Pages: 979231-979231

    • DOI

      10.1002/jnr.21032

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390272, KAKENHI-PLANNED-23111003

  • [Journal Article] Analysis of PLA2G6 in patients with frontotemporal type of dementia2011
    • Author(s)
      Tomiyama H, Yoshino H, Hattori N
    • Journal Title

      Parkinsonism Relat Disord

      Volume: 17(6) Pages: 493-4

    • Data Source
      KAKENHI-PROJECT-21390272

  • [Journal Article] Comprehensive mutational analysis of LRRK2 reveals variants supporting association with autosomal dominant Parkinson's disease2011
    • Author(s)
      Seki N, Takahashi Y, Tomiyama H, Rogaeva E, Murayama S, Mizuno Y, Hattori N, Marras C, Lang AE, George-Hyslop PS, Goto J, Tsuji S
    • Journal Title

      J Hum Genet

      Volume: 56(9) Pages: 671-671

    • NAID

      10030660937

    • Data Source
      KAKENHI-PROJECT-21390272

  • [Journal Article] Genetic Epidemiology of Parkinson's Disease Consortium. Role of sepiapterin reductase gene at the PARK3 locus in Parkinson's disease2011
    • Author(s)
      Sharma M, Maraganore DM, Ioannidis JP, Riess O, Aasly JO, Annesi G, Abahuni N, Bentivoglio AR, Brice A, Van Broeckhoven C, Chartier-Harlin MC, Destee A, Djarmati A, Elbaz A, Farrer M, Ferrarese C, Gibson JM, Gispert S, Hattori N, Jasinska-Myga B, Klein C
    • Journal Title

      Neurobiol Aging

      Volume: 32(11)

    • Data Source
      KAKENHI-PROJECT-21390272

  • [Journal Article] Differential regional distribution of phosphorylated tau and synapse loss in the nucleus accumbens in tauopathy model mice2011
    • Author(s)
      Kambe T, Motoi Y, Inoue R, Kojima N, Tada N, Kimura T, Sahara N, Yamashita S, Mizoroki T, Takashima A, Shimada K, Ishiguro K, Mizuma H, Onoe H, Mizuno Y, Hattori N
    • Journal Title

      Neurobiol Dis

      Volume: 42(3) Pages: 404-14

    • Data Source
      KAKENHI-PUBLICLY-23110518

  • [Journal Article] Mitochondrial membrane potential decrease caused by loss of PINK1 is not due to proton leak, but to respiratory chain defects.2011
    • Author(s)
      Amo T, Sato S, Saiki S, Wolf AM, Toyomizu M, Gautier CA, Shen J, Ohta S, Hattori N.
    • Journal Title

      Neurobiol Dis 41

      Pages: 111-118

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790853

  • [Journal Article] Genetic Epidemiology of Parkinson's disease consortium. A large-scale genetic association study to evaluate the contribution of Omi/HtrA2(PARK13) to Parkinson's disease2011
    • Author(s)
      Kruger R, Sharma M, Riess O, Gasser T, Van Broeckhoven C, Theuns J, Aasly J, Annesi G, Bentivoglio AR, Brice A, Djarmati A, Elbaz A, Farrer M, Ferrarese C, Gibson JM, Hadjigeorgiou GM, Hattori N, Ioannidis JP, Jasinska-Myga B, Klein C, Lambert JC, Lesage S, Lin JJ, Lynch T, Mellick GD, de Nigris F, Opala G, Prigione A, Quattrone A, Ross OA, Satake W, Silburn PA, Tan EK, Toda T, Tomiyama H, Wirdefeldt K, Wszolek Z, Xiromerisiou G, Maraganore DM
    • Journal Title

      Neurobiol Aging

      Volume: 32(3)

    • Data Source
      KAKENHI-PROJECT-21390272

  • [Journal Article] Demographic, Clinical, and Radiologic Predictors of Neurologic Deterioration in Patients with Acute Ischemic Stroke2011
    • Author(s)
      Miyamoto N, Tanaka Y, Ueno Y, Kawamura M, Shimada Y, Tanaka R, Hattori N, Urabe T
    • Journal Title

      J Stroke Cerebrovasc Dis

      Volume: (In Press)

    • Data Source
      KAKENHI-PROJECT-21390272

  • [Journal Article] Comprehensive mutational analysis of LRRK2 reveals variants supporting association with autosomal dominant Parkinson's disease2011
    • Author(s)
      Seki N, Takahashi Y, Tomiyama H, Rogaeva E, Murayama S, Mizuno Y, Hattori N, Marras C, Lang AE, George-Hyslop PS, Goto J, Tsuji S
    • Journal Title

      J Hum Genet

      Volume: 56 Pages: 671-5

    • NAID

      10030660937

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591098

  • [Journal Article] Analysis of PLA2G6 in patients with frontotemporal type of dementia2011
    • Author(s)
      Tomiyama H, Yoshino H, Hattori N
    • Journal Title

      Parkinsonism Relat Disord

      Volume: 17 Pages: 493-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591098

  • [Journal Article] Convulsive movements in bilateral paramedian thalamic and midbrain infarction2011
    • Author(s)
      Yamashiro K, Furuya T, Noda K, Urabe T, Hattori N, Okuma Y
    • Journal Title

      Case Rep Neurol

      Volume: 3(3) Pages: 289-289

    • Data Source
      KAKENHI-PROJECT-21390272

  • [Journal Article] Gradient Echo T2*-weighted Magnetic Resonance Imaging Revealing Cerebral Microbleeds in A Patient with Microscopic Polyangiitis Complicated by Cerebrovascular Disease2011
    • Author(s)
      Yamashiro K, Mori A, Shimada Y, Furuya T, Noda K, Urabe T, Hattori N, Okuma Y
    • Journal Title

      J Stroke Cerebrovasc Dis

      Volume: (Epub ahead of print)

    • Data Source
      KAKENHI-PUBLICLY-23110518

  • [Journal Article] Parkin-mediated protection of dopaminergic neurons in a chronic MPTP-minipump mouse model of Parkinson disease2011
    • Author(s)
      Yasuda T, Hayakawa H, Nihira T, Ren YR, Nakata Y, Nagai M, Hattori N, Miyake K, Takada M, Shimada T, Mizuno Y, Mochizuki H
    • Journal Title

      J Neuropathol Exp Neurol

      Volume: 70(8) Pages: 686-97

    • Data Source
      KAKENHI-PROJECT-21390272

  • [Journal Article] Phenotype of the 202 adenine deletion in the parkin gene : 40 years of follow-up2011
    • Author(s)
      Hassin-Baer S, Hattori N, Cohen OS, Massarwa M, Israeli-Korn SD, Inzelberg R
    • Journal Title

      Mov Disord

      Volume: 26(4) Pages: 719-22

    • Data Source
      KAKENHI-PROJECT-21390272

  • [Journal Article] Visual Grasping in Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17(Microtubule-Associated with Protein Tau): A Comparison of 123 I-IMP Brain Perfusion SPECT Analysis with Progressive Supranuclear Palsy2011
    • Author(s)
      Ogaki K, Motoi Y, Li Y, Tomiyama H, Shimizu N, Takanashi M, Nakanishi A, Yokoyama K, Hattori N
    • Journal Title

      Mov Disord

      Volume: 26 Pages: 561-3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591098

  • [Journal Article] PLA2G6 variant in Parkinson's disease2011
    • Author(s)
      Tomiyama H, Yoshino H, Ogaki K, Li L, Yamashita C, Li Y, Funayama M, Sasaki R, Kokubo Y, Kuzuhara S, Hattori N
    • Journal Title

      J Hum Genet

      Volume: 56 Pages: 401-3

    • NAID

      10030659472

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591098

  • [Journal Article] Methotrexate leukoencephalopathy mimics acute progressive stroke2011
    • Author(s)
      Tanaka R, Sasaki-Ikesawa K, Shimura H, Nishioka K, Hattori N, Tanaka S
    • Journal Title

      J Neurol

      Volume: 258(11) Pages: 2083-2083

    • Data Source
      KAKENHI-PROJECT-21390272

  • [Journal Article] Differential regional distribution of phosphorylated tau and synapse loss in the nucleus accumbens in tauopathy model mice2011
    • Author(s)
      Kambe T, Motoi Y, Inoue R, Kojima N, Tada N, Kimura T, Sahara N, Yamashita S, Mizoroki T, Takashima A, Shimada K, Ishiguro K, Mizuma H, Onoe H, Mizuno Y, Hattori N
    • Journal Title

      Neurobiol Dis

      Volume: 42(3) Pages: 404-14

    • Data Source
      KAKENHI-PROJECT-21390272

  • [Journal Article] PLA2G6 variant in Parkinson's disease2011
    • Author(s)
      Tomiyama H, Yoshino H, Ogaki K, Li L, Yamashita C, Li Y, Funayama M, Sasaki R, Kokubo Y, Kuzuhara S, Hattori N
    • Journal Title

      J Hum Genet

      Volume: 56(5) Pages: 401-3

    • NAID

      10030659472

    • Data Source
      KAKENHI-PROJECT-21390272

  • [Journal Article] Improvements in both psychosis and motor signs in Parkinson's disease, and changes in regional cerebral blood flow after electroconvulsive therapy2011
    • Author(s)
      Usui C, Hatta K, Doi N, Kubo S, Kamigaichi R, Nakanishi A, Nakamura H, Hattori N, Arai H
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry

      Volume: 35(7) Pages: 1704-8

    • Data Source
      KAKENHI-PROJECT-21390272

  • [Journal Article] Art and Parkinson's disease : a dramatic change in an artist's style as an initial symptom2011
    • Author(s)
      Shimura H, Tanaka R, Urabe T, Tanaka S, Hattori N
    • Journal Title

      J Neurol

      Volume: (In Press)

    • Data Source
      KAKENHI-PROJECT-21390272

  • [Journal Article] Association of LRRK2 exonic variants with susceptibility to Parkinson's disease : a case-control study2011
    • Author(s)
      Ross OA, Soto-Ortolaza AI, Heckman MG, Aasly JO, Abahuni N, Annesi G, Bacon JA, Bardien S, Bozi M, Brice A, Brighina L, Van Broeckhoven C, Carr J, Chartier-Harlin MC, Dardiotis E, Dickson DW, Diehl NN, Elbaz A, Ferrarese C, Ferraris A, Fiske B, Gibson JM,Gibson R, Hadjigeorgiou GM, Hattori N, Ioannidis JP, Jasinska-Myga B, Jeon BS, Kim YJ, Klein C, Kruger R, Kyratzi E, Lesage S, Lin CH, Lynch T, Maraganore DM, Mellick GD, Mutez E, Nilsson C, Opala G, Park SS, Puschmann A, Quattrone A, Sharma M, Silburn PA, Sohn YH, Stefanis L, Tadic V, Theuns J, Tomiyama H, Uitti RJ, Valente EM, van de Loo S, Vassilatis DK, Vilarino-Guell C, White LR, Wirdefeldt K, Wszolek ZK, Wu RM, Farrer MJ ; on behalf of the Genetic Epidemiology Of Parkinson's Disease(GEO-PD) Consortium
    • Journal Title

      Lancet Neurol

      Volume: 10 Pages: 898-908

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591098

  • [Journal Article] Genetic mutations and functions of PINK12011
    • Author(s)
      Kawajiri S, Saiki S, Sato S, Hattori N
    • Journal Title

      Trends Pharmacol Sci

      Volume: 32(10) Pages: 573-573

    • Data Source
      KAKENHI-PROJECT-21390272

  • [Journal Article] The effect of Ndrg2 expression on astroglial activation2011
    • Author(s)
      Takeichi T, Takarada-Iemata M, Hashida K, Sudo H, Okuda T, Kokame K, Hatano T, Takanashi M, Funabe S, Hattori N, Kitamura O, Kitao Y, Hori O
    • Journal Title

      Neurochem Int

      Volume: 59(1)

    • NAID

      120003221535

    • Data Source
      KAKENHI-PROJECT-21390272

  • [Journal Article] A large-scale genetic association study to evaluate the contribution of Omi/HtrA2(PARK13) to Parkinson's disease2011
    • Author(s)
      Kruger R, Sharma M, Riess O, Gasser T, Van Broeckhoven C, Theuns J, Aasly J, Annesi G, Bentivoglio AR, Brice A, Djarmati A, Elbaz A, Farrer M, Ferrarese C, Gibson JM, Hadjigeorgiou GM, Hattori N, Ioannidis JP, Jasinska-Myga B, Klein C, Lambert JC, Lesage S, Lin JJ, Lynch T, Mellick GD, de Nigris F, Opala G, Prigione A, Quattrone A, Ross OA, Satake W, Silburn PA, Tan EK, Toda T, Tomiyama H, Wirdefeldt K, Wszolek Z, Xiromerisiou G, Maraganore DM ; for the Genetic Epidemiology of Parkinson's disease consortium
    • Journal Title

      Neurobiol Aging

      Volume: 32

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591098

  • [Journal Article] Posterior hypoperfusion in Parkinson's disease with and without dementia measured with arterial spin labeling MRI2011
    • Author(s)
      Kamagata K, Motoi Y, Hori M, Suzuki M, Nakanishi A, Shimoji K, Kyougoku S, Kuwatsuru R, Sasai K, Abe O, Mizuno Y, Aoki S, Hattori N
    • Journal Title

      J Magn Reson Imaging

      Volume: 33(4) Pages: 803-7

    • Data Source
      KAKENHI-PROJECT-21390272

  • [Journal Article] Acute effects of bilateral subthalamic stimulation on decision-making in Parkinson's disease2011
    • Author(s)
      Oyama G, Shimo Y, Natori S, Nakajima M, Ishii H, Arai H, Hattori N
    • Journal Title

      Parkinsonism Relat Disord

      Volume: 17(3) Pages: 189-93

    • Data Source
      KAKENHI-PROJECT-21390272

  • [Journal Article] Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition.2011
    • Author(s)
      Saiki S, Sasazawa Y, Imamichi Y, Kawajiri S, Fujimaki T, Tanida I, Kobayashi H, Sato F, Kei-Ichi Ishikawa, Sato S, Imoto M, Hattori N.
    • Journal Title

      Autophagy

      Volume: 7 Pages: 176-187

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790853

  • [Journal Article] Analysis of PLA2G6 in patients with frontotemporal type of dementia2011
    • Author(s)
      Tomiyama H, Yoshino H, Hattori N
    • Journal Title

      Parkinsonism Relat Disord

      Volume: 17(6) Pages: 493-4

    • Data Source
      KAKENHI-PUBLICLY-23110518

  • [Journal Article] Exendin-4, a glucagon-like peptide-1 receptor agonist, provides neuroprotection in mice transient focal cerebral ischemia2011
    • Author(s)
      Teramoto S, Miyamoto N, Yatomi K, Tanaka Y, Oishi H, Arai H, Hattori N, Urabe T
    • Journal Title

      J Cereb Blood Flow Metab

      Volume: 31(8) Pages: 1696-1696

    • Data Source
      KAKENHI-PROJECT-21390272

  • [Journal Article] PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy.2011
    • Author(s)
      Matsuda N, Sato S, Shiba K, Okatsu K, Saisho K, Gautier CA, Sou YS, Saiki S, Kawajiri S, Sato F, Kimura M, Komatsu M, Hattori N, Tanaka K.
    • Journal Title

      J Cell Biol.

      Volume: 189(2) Pages: 211-21

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390272

  • [Journal Article] The development and validation of a new comprehensive self-completing questionnaire for symptoms in Parkinson's disease (MASAC-PD 31)2011
    • Author(s)
      Nogawa S, Takahashi H, Hattori N
    • Journal Title

      Rinsho Shinkeigaku

      Volume: 51(5) Pages: 321-9

    • NAID

      10031164013

    • Data Source
      KAKENHI-PUBLICLY-23110518

  • [Journal Article] DJ-1 associates with synaptic membranes2011
    • Author(s)
      Usami Y, Hatano T, Imai S, Kubo S, Sato S, Saiki S, Fujioka Y, Ohba Y, Sato F, Funayama M, Eguchi H, Shiba K, Ariga H, Shen J, Hattori N
    • Journal Title

      Neurobiol Dis

      Volume: 43(3) Pages: 651-651

    • Data Source
      KAKENHI-PROJECT-21390272

  • [Journal Article] Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition.2011
    • Author(s)
      Saiki S, Sasazawa Y, Imamichi Y, Kawajiri S, Fujimaki T, Tanida I, Kobayashi H, Sato F, Kei-Ichi Ishikawa, Sato S, Imoto M, Hattori N.
    • Journal Title

      Autophagy 7

      Pages: 176-87

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790853

  • [Journal Article] Posterior hypoperfusion in Parkinson's disease with and without dementia measured with arterial spin labeling MRI2011
    • Author(s)
      Kamagata K, Motoi Y, Hori M, Suzuki M, Nakanishi A, Shimoji K, Kyougoku S, Kuwatsuru R, Sasai K, Abe O, Mizuno Y, Aoki S, Hattori N
    • Journal Title

      J Magn Reson Imaging

      Volume: 33(4) Pages: 803-7

    • DOI

      10.1002/jmri.22515

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-23110518, KAKENHI-PLANNED-23111003

  • [Journal Article] Parkinson's disease-related LRRK2 G2019mutation results from independent mutational events in humans2010
    • Author(s)
      Lesage S, Patin E, Condroyer C, Leutenegger AL, Lohmann E, Giladi N, Bar-Shira A, Belarbi S, Hecham N, Pollak P, Ouvrard-Hernandez AM, Bardien S, Carr J, Benhassine T, Tomiyama H, Pirkevi C, Hamadouche T, Cazeneuve C, Basak AN, Hattori N, Durr A, Tazir M,Orr-Urtreger A, Quintana-Murci L, Brice A
    • Journal Title

      Hum Mol Genet

      Volume: 19 Pages: 1998-2004

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591098

  • [Journal Article] PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy2010
    • Author(s)
      Noriyuki Matsuda, Shigeto Sato, Kahori Shiba, Kei Okatsu, Keiko Saisho, Clement A Gautier, Yu-shin Sou, Shinji Saiki, Sumihiro Kawajiri, Fumiaki Sato, Mayumi Kimura, Masaaki Komatsu, Nobutaka Hattori, Keiji Tanaka
    • Journal Title

      Journal of cell biology (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390272

  • [Journal Article] PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy.2010
    • Author(s)
      Kawajiri S, Saiki S, Sato S, Sato F, Eguchi H, Hattori N
    • Journal Title

      FEBS Letters (印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790853

  • [Journal Article] PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy.2010
    • Author(s)
      Kawajiri S, Saiki S, Sato S, Sato F, Hatano T, Eguchi H, Hattori N.
    • Journal Title

      FEBS Lett 584 Joint first authors

      Pages: 1073-1079

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790853

  • [Journal Article] Zonisamide reduces cell death in SH-SY5Y cells via an anti-apoptotic effect and by upregulating MnSOD.2010
    • Author(s)
      Kawajiri S, Machida Y, Saiki S, Sato S, Hattori N.
    • Journal Title

      Neurosci Lett 481

      Pages: 88-91

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790853

  • [Journal Article] PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy.2010
    • Author(s)
      Kawajiri S, Saiki S, Sato S, Sato F, Eguchi H, Hattori N
    • Journal Title

      FEBS Letters

      Volume: 584 Pages: 1073-1079

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790853

  • [Journal Article] Parkinson's disease-related LRRK2 G2019S mutation results from independent mutational events in humans.2010
    • Author(s)
      Lesage S, Patin E, Condroyer C, Leutenegger AL, Lohmann E, Giladi N, Bar-Shira A, Belarbi S, Hecham N, Pollak P, Ouvrard-Hernandez AM, Bardien S, Carr J, Benhassine T, Tomiyama H, Pirkevi C, Hamadouche T, Cazeneuve C, Basak AN, Hattori N, Durr A, Tazir M, Orr-Urtreger A, Quintana-Murci L, Brice ; A French Parkinson's Disease Genetics Study Group.
    • Journal Title

      Hum Mol Genet.

      Volume: 19(10) Pages: 1998-2004

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390272

  • [Journal Article] Impaired in vivo dopamine release in parkin knockout mice.2010
    • Author(s)
      Oyama G, Yoshimi K, Natori S, Chikaoka Y, Ren YR, Funayama M, Shimo Y, Takahashi R, Nakazato T, Kitazawa S, Hattori N.
    • Journal Title

      Brain Res.

      Volume: 1352 Pages: 214-22

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390272

  • [Journal Article] A rotarod test for evaluation of motor skill learning2010
    • Author(s)
      Hiromi Shiotsuki, Kenji Yoshimi, Yasushi Shimo, Manabu Funayama, Yukio Takamatsu, Kazutaka Ikeda, Ryosuke Takahashi, Shigeru Kitazawa, Nobutaka Hattori
    • Journal Title

      Journal Of Neuroscience Methods (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390272

  • [Journal Article] Clinical course of the first Asian family with Parkinsonism related to SNCA triplication2010
    • Author(s)
      Sekine T, Kagaya H, Funayama M, Li Y, Yoshino H, Tomiyama H, Hattori N
    • Journal Title

      Mov Disord

      Volume: 25 Pages: 2871-75

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591098

  • [Journal Article] Clinical course of the first Asian family with Parkinsonism related to SNCA triplication.2010
    • Author(s)
      Sekine T, Kagaya H, Funayama M, Li Y, Yoshino H, Tomiyama H, Hattori N.
    • Journal Title

      Mov Disord

      Volume: 25 Pages: 2871-75

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591098

  • [Journal Article] Zonisamide reduces cell death in SH-SY5Y cells via an anti-apoptotic effect and by upregulating MnSOD.2010
    • Author(s)
      Kawajiri S, Machida Y, Saiki S, Sato S, Hattori N.
    • Journal Title

      Neuroscience Letters

      Volume: 481 Pages: 88-91

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790853

  • [Journal Article] Mechanisms of genomic instabilities underlying two common fragile-site-associated loci, PARK2 and DMD, in germ cell and cancer cell lines2010
    • Author(s)
      Mitsui J, Takahashi Y, Goto J, Tomiyama H, Ishikawa S, Yoshino H, Minami N, Smith DI, Lesage S, Aburatani H, Nishino I, Brice A, Hattori N, Tsuji S
    • Journal Title

      Am J Hum Genet

      Volume: 87 Pages: 75-89

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591098

  • [Journal Article] No evidence for pathogenic role of GIGYF2 mutation in Parkinson disease in Japanese patients2010
    • Author(s)
      Li L, Funayama M, Tomiyama H, Li Y, Yoshino H, Sasaki R, Kokubo Y, Kuzuhara S, Mizuno Y, Hattori N
    • Journal Title

      Neurosci Lett

      Volume: 479 Pages: 245-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591098

  • [Journal Article] PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy.2010
    • Author(s)
      Matsuda N, Sato S, Shiba K, Okatsu K, Saisho K, Gautier CA, Sou YS, Saiki S, Kawajiri S, Sato F, Kimura M, Komatsu M, Hattori N, Tanaka K.
    • Journal Title

      J Cell Biol 189

      Pages: 211-221

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790853

  • [Journal Article] Phenotypicspectrum of patients with PLA2G6 mutation and PARK14-linked parkinsonism2010
    • Author(s)
      Yoshino H, Tomiyama H, Tachibana N, Ogaki K, Li Y, Funayama M, Hashimoto T, Takashima S, Hattori N
    • Journal Title

      Neurology

      Volume: 75 Pages: 1356-61

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591098

  • [Journal Article] PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy.2010
    • Author(s)
      Kawajiri S, Saiki S, Sato S, Sato F, Hatano T, Eguchi H, Hattori N
    • Journal Title

      FEBS Lett 584(6)

      Pages: 1073-9

    • Data Source
      KAKENHI-PROJECT-20023028

  • [Journal Article] Rapid screening of ATP13A2 variant with high-resolution melting analysis2010
    • Author(s)
      Funayama M, Tomiyama H, Wu RM, Ogaki K, Yoshino H, Mizuno Y, Hattori N
    • Journal Title

      Mov Disord

      Volume: 25 Pages: 2434-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591098

  • [Journal Article] PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy.2010
    • Author(s)
      Matsuda N, Sato S, Shiba K, Okatsu K, Saisho K, Gautier CA, Sou YS, Saiki S, Kawajiri S, Sato F, Kimura M, Komatsu M, Hattori N, Tanaka K.
    • Journal Title

      Journal of Cell Biology

      Volume: 189 Pages: 211-221

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790853

  • [Journal Article] Mutations for Gaucher disease confer a high susceptibility to Parkinson disease.2009
    • Author(s)
      Mitsui J, Mizuta I, Toyoda A, Ashida R, Takahashi Y, Goto J, Fukuda Y, Date H, Iwata A, Yamamoto M, Hattori N, Murata M, Toda T, Tsuji S.
    • Journal Title

      Arch Neurol 66

      Pages: 571-576

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019044

  • [Journal Article] Preserved cardiac 123I-MIBG uptake and lack of severe autonomic dysfunction in a PARK9 patient2009
    • Author(s)
      Kanai K, Asahina M, Arai K, Tomiyama H, Kuwabara Y, Uchiyama T, Sekiguchi Y, Funayama M, Kuwabara S, Hattori N, Hattori T.
    • Journal Title

      Movement Disorders 24

      Pages: 1403-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591098

  • [Journal Article] Effective control of catatonia in Parkinson's disease by electroconvulsive therapy : a case report.2009
    • Author(s)
      Kamigaichi R, Kubo S, Ishikawa K, Yokoyama K, Ogaki K, Usui C, Hatta K, Arai H, Mochizuki H, Hattori N
    • Journal Title

      Eur J Neurol 16

    • Data Source
      KAKENHI-PROJECT-20591010

  • [Journal Article] Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease2009
    • Author(s)
      Satake W, Nakabayashi Y, Mizuta I, Hirota Y, Ito C, Kubo M, Kawaguchi T, Tsunoda T, Watanabe M, Takeda A, Tomiyama H, Nakashima K, Hasegawa K, Obata F, Yoshikawa T, Kawakami H, Sakoda S, Yamamoto M, Hattori N, Murata M, Nakamura Y, Toda T
    • Journal Title

      Nature Genet

      Volume: 41 Pages: 1303-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591098

  • [Journal Article] Programmed cell death-2 isoforml is ubiquitinated by parkin and increased in the substantia nigra of patients with autosomal recessive Parkinson's disease.2009
    • Author(s)
      Fukae J, Sato S, Shiba K, Sato K, Mori H, Sharp PA, Mizuno Y, Hattori N
    • Journal Title

      FEBS Lett 583

      Pages: 521-525

    • Data Source
      KAKENHI-PROJECT-20023028

  • [Journal Article] Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease.2009
    • Author(s)
      Satake W, Nakabayashi Y, Mizuta I, Hirota Y, Ito C, Kubo M, Kawaguchi T, Tsunoda T, Watanabe M, Takeda A, Tomiyama H, Nakashima K, Hasegawa K, Obata F, Yoshikawa T, Kawakami H, Sakoda S, Yamamoto M, Hattori N, Murata M, Nakamura Y, Toda T
    • Journal Title

      Nat Genet 41

      Pages: 1303-1307

    • Data Source
      KAKENHI-PROJECT-20023028

  • [Journal Article] Mutation analysis for DJ-1 in sporadic and familial parkinsonism : Screening strategy in parkinsonism2009
    • Author(s)
      Tomiyama H, Li Y, Yoshino H, Mizuno Y, Kubo S, Toda T, Hattori N
    • Journal Title

      Neurosci Lett

      Volume: 455 Pages: 159-61

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591098

  • [Journal Article] Mutation analysis for DJ-1 in sporadic and familial parkinsonism : screening strategy in parkinsonism.2009
    • Author(s)
      Tomiyama H, Li Y, Yoshino H, Mizuno Y, Kubo S, Toda T, Hattori N
    • Journal Title

      Neurosci Lett 455

      Pages: 159-161

    • Data Source
      KAKENHI-PROJECT-20591010

  • [Journal Article] Parkin stabilizes PINK1 through direct interaction.2009
    • Author(s)
      Shiba K, Arai T, Sato S, Kubo S, Ohba Y, Mizuno Y, Hattori N
    • Journal Title

      Biochem Biophys Res Commun 383

      Pages: 331-335

    • Data Source
      KAKENHI-PROJECT-20591010

  • [Journal Article] Screening PARK Genes for Mutations in Early Onset Parkinson's Disease Patients from Queensland, Australia2009
    • Author(s)
      Mellick GD, Siebert GA, Funayama M, Buchanan DD, Li Y, Imamichi Y, Yoshino H, Silburn PA, Hattori N
    • Journal Title

      Parkinsonism & Related Disorders 15

      Pages: 105-109

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20023028

  • [Journal Article] Excitatory amino acid transporter 2 associates with phosphorylated tau and is localized in neurofibrillary tangles of tauopathic brains.2009
    • Author(s)
      Sasaki K, Shimura H, Itaya M, Tanaka R, Mori H, Mizuno Y, Kosik KS, Tanaka S, Hattori N
    • Journal Title

      FEBS Lett 583

      Pages: 2194-200

    • Data Source
      KAKENHI-PROJECT-20023028

  • [Journal Article] Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease2009
    • Author(s)
      Satake W, Nakabayashi Y, Mizuta I, Hirota Y, Ito C, Kubo M, Kawaguchi T, Tsunoda T, Watanabe M, Takeda A, Tomiyama H, Nakashima K, Hasegawa K, Obata F, Yoshikawa T, Kawakami H, Sakoda S, Yamamoto M, Hattori N, Murata M, Nakamura Y, Toda T.
    • Journal Title

      Nature Genet 41

      Pages: 1303-1307

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019044

  • [Journal Article] Mutation analysis for DJ-1 in sporadic and familial parkinsonism: Screening strategy in parkinsonism.2009
    • Author(s)
      Tomiyama H, Li Y, Yoshino H, Mizuno Y, Kubo S, Toda T, Hattori N
    • Journal Title

      Neurosci Lett 455

      Pages: 159-161

    • Data Source
      KAKENHI-PROJECT-20023028

  • [Journal Article] A LRRK2 G2019S mutation carrier from Turkey shares the Japanese haplotype2009
    • Author(s)
      Pirkevi C, Lesage S, Condroyer C, Tomiyama H, Hattori N, Ertan S, Brice A, Ba. ak AN
    • Journal Title

      Neurogenetics

      Volume: 10 Pages: 271-3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591098

  • [Journal Article] A new mutation in the GCH1 gene presents as early-onset Parkinsonism2009
    • Author(s)
      Momma K, Funayama M, Li Y, Ichinose H, Motoyoshi K, Hattori N, Mizuno Y, Kamakura K
    • Journal Title

      Parkinsonism & Related Disorders 15

      Pages: 160-161

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20023028

  • [Journal Article] Parkin stabilizes PINK1 through direct interaction.2009
    • Author(s)
      Shiba K, Arai T, Sato S, Kubo S, Ohba Y, Mizuno Y, Hattori N
    • Journal Title

      Biochem Biophys Res Commun 383

      Pages: 331-335

    • Data Source
      KAKENHI-PROJECT-20023028

  • [Journal Article] Evaluation of the genetic contribution of Omi/HtrA2 to Parkinson disease in a large collaborative study2009
    • Author(s)
      Kruger R, Sharma M, Riess O, Gasser T, van Broeckhoven C, Aasly J, Annesi G, Bentivoglio, AR Brice A, Elbaz A, Farrer M, Ferrarese C, Ferraris A, Hadjigeorgiou GM, Hattori N, Tomiyama H, et al.
    • Journal Title

      Neurobiol Aging (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591098

  • [Journal Article] Unmet needs of patients with Parkinson's disease : interview survey of patients and caregivers.2009
    • Author(s)
      Hatano T, Kubo S, Shimo Y, Nishioka K, Hattori N
    • Journal Title

      J Int Med Res 37

      Pages: 717-726

    • Data Source
      KAKENHI-PROJECT-20591010

  • [Journal Article] Non-replication of association for six polymorphisms from meta-analysis of genome-wide association studies of Parkinson's disease : Large-scale collaborative study2009
    • Author(s)
      Evangelou E, Maraganore DM, Annesi G, Brighina L, Brice A, Elbaz A, Ferrarese C, Hadjigeorgiou GM, Krueger R, Lambert JC, Lesage S, Markopoulou K, Mellick GD, Meeus B, Pedersen NL, Quattrone A, Van Broeckhoven C, Sharma M, Silburn PA, Tan EK, Wirdefeldt K, Ioannidis JP, Sutherland GT, Siebert GA. Theuns J, Crosiers D, Pickut B, Pals P, Engelborghs S, Nuytemans K, De Deyn PP, Cras P, Agid Y, Bonnet AM, Borg M, Brice A, Broussolle E, Damier P, Destee A, Durr A, Durif F, Lesage S, Lohmann E, Pollak P, Rascol O, Tison F, Tranchant C, Viallet F, Vidailhet M, Tzourio C, Amouyel P, Loriot MA, Gasser T, Riess O, Berg D, Schulte C, Klein C, Djarmati A, Lohmann K, Xiromerisiou G, Dardiotis E, Kountra P, Hattori N, Tomiyama H, Funayama M, Yoshino H, Li Y, Valente EM, FerraBentivoglio AR, Ialongo T, Riva C, Corradi B, Opala G, Myga BJ, Duda GK, Jedynak MB, Belin AC, Galter LD, Westerlund M, Sydow O, Nilsson C, Puschmann A, Maraganore DM, Ahlskog Mariza de Andrade JE, Lesnick TG, Rocca WA, Checkoway H
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet

      Volume: 153B(1) Pages: 220-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591098

  • [Journal Article] Preserved cardiac 123I-MIBG uptake and lack of severe autonomic dysfunction in a PARK9 patient2009
    • Author(s)
      Kanai K, Asahina M, Arai K, Tomiyama H, Kuwabara Y, Uchiyama T, Sekiguchi Y, Funayama M, Kuwabara S, Hattori N, Hattori T
    • Journal Title

      Mov Disord

      Volume: 24 Pages: 1403-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591098

  • [Journal Article] Programmed cell death-2 isoform1 is ubiquitinated by parkin and increased in the substantia nigra of patients with autosomal recessive Parkinson's disease.2009
    • Author(s)
      Fukae J, Sato S, Shiba K, Sato K, Mori H, Sharp PA, Mizuno Y, Hattori N
    • Journal Title

      EEBS Lett 383

      Pages: 521-525

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20023028

  • [Journal Article] Familial parkinsonism with digenic parkin and PINK1 mutations2008
    • Author(s)
      Funayama M, Li Y, Tsoi TH, Lam CW, Ohi T, Yazawa S, Uyama E, Djaldetti R, Melamed E, Yoshino H, Imamichi Y, Takashima H, Nishioka K, Sato K, Tomiyama H, Kubo S, MD, Mizuno Y, Hattori N
    • Journal Title

      Mov Disord 65

      Pages: 802-808

    • Data Source
      KAKENHI-PROJECT-19390244

  • [Journal Article] LRRK2 P755L variant in sporadic Parkinson's disease2008
    • Author(s)
      Tomiyama H, Mizuta I, Li Y, Funayama M, Yoshino H, Li L, Murata M, Yamamoto M, Kubo S, Mizuno Y, Toda T, Hattori N
    • Journal Title

      J Hum Genet 53

      Pages: 1012-5

    • NAID

      10025584966

    • Data Source
      KAKENHI-PROJECT-19390244

  • [Journal Article] PARK9-linked parkinsonism in Eastern Asia: Mutation detection in ATP13A2 and clinical phenotype.2008
    • Author(s)
      Ning Y, Kanai K, Tomiyama H, Li Y, Funayama M, Yoshino H, Sato S, Asahina M, Kuwabara S, Takeda A, Hattori T, Mizuno Y, Hattori N
    • Journal Title

      Neurology 70

      Pages: 1491-1493

    • Data Source
      KAKENHI-PROJECT-20023028

  • [Journal Article] LRRK2 P755L variant in sporadic Parkinson's disease.2008
    • Author(s)
      Tomiyama H, Mizuta I, Li Y, Funayama M, Yoshino H, Li L, Murata M, Yamamoto M, Kubo SI, Mizuno Y, Toda T, Hattori N.
    • Journal Title

      J Hum Genet 53

      Pages: 1012-1015

    • NAID

      10025584966

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019044

  • [Journal Article] Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease2008
    • Author(s)
      Ross OA, Wu YR, Lee MC, Funayama M, Chen ML, Soto AI, Mata IF, Lee-Chen GJ, Chen CM, Tang M, Zhao Y, Hattori N, Farrer MJ, Tan EK, Wu RM
    • Journal Title

      Ann Neurol 64

      Pages: 88-92

    • Data Source
      KAKENHI-PROJECT-19390244

  • [Journal Article] Mutation analysis of the PINK1 gene in 391 patients with Parkinson disease2008
    • Author(s)
      Kumazawa R, Tomiyama H, Li Y, Imamichi Y, Funayama M, Yoshino H, Yokochi F, Fukusako T, Takehisa Y, Kashihara K, Kondo T, Elibol B, Bostantjopoulou S, Toda T, Takahashi H, Yoshii F, Mizuno Y, Hattori N
    • Journal Title

      Arch Neurol 65(6)

      Pages: 802-8

    • Data Source
      KAKENHI-PROJECT-19390244

  • [Journal Article] Progress in the pathogenesis and genetics of Parkinson's disease2008
    • Author(s)
      Mizuno Y, Hattori N, Kubo SI, Sato S, Nishioka K, Hatano T, Tomiyama H, Funayama M, Machida Y, Mochizuki H. Review
    • Journal Title

      Philos Trans R Soc Lond B Biol Sci 27

      Pages: 2215-2227

    • Data Source
      KAKENHI-PROJECT-19390244

  • [Journal Article] Mutation analysis of the PINK1 gene in 391 patients with Parkinson disease.2008
    • Author(s)
      Kumazawa R, Tomiyama H, Li Y, Imamichi Y, Funayama M, Yoshino H, Yokochi F, Fukusako T, Takehisa Y, Kashihara K, Kondo T, Elibol B, Bostantjopoulou S, Toda T, Takahashi H, Yoshii F, Mizuno Y, Hattori N
    • Journal Title

      Arch Neurol 65

      Pages: 802-808

    • Data Source
      KAKENHI-PROJECT-20023028

  • [Journal Article] Mutation analysis of the PINK1 gene in 391 patients with Parkinson's disease2008
    • Author(s)
      Kumazawa R, Tomiyama H, Li Y, Imamichi Y, Funayama M, Yoshino H, Yokochi F, Fukusako T, Takehisa Y, Kashihara K, Kondo T, Elibol B, Bostantjopoulou S, Toda T, Takahashi H, Yoshii F, Mizuno Y, Hattori N.
    • Journal Title

      Arch Neurol 65

      Pages: 802-808

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019044

  • [Journal Article] Visual impairment in Parkinson's disease treated with amantadine : Case report and review of the literature.2008
    • Author(s)
      Kubo S, Iwatake A, Ebihara N, Murakami A, Hattori N
    • Journal Title

      Parkinsonism Relat Disord 14

      Pages: 166-169

    • Data Source
      KAKENHI-PROJECT-20591010

  • [Journal Article] Calbindin 1, fibroblast growth factor 20, and・-synuclein in Parkinson's disease.2008
    • Author(s)
      Mizuta I, Tsunoda T, Satake W, Nakabayashi Y, Watanabe M, Takeda A, Hasegawa K, Nakashima K, Yamamoto M, Hattori N, Murata M, Toda T.
    • Journal Title

      Hum Genet 124

      Pages: 89-94

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019044

  • [Journal Article] Mutation analyses in amyotrophic lateral sclerosis/parkinsonism-dementia complex of Kii, Japan2008
    • Author(s)
      Tomiyama H, Kokubo Y, Sasaki R, Li Y, Imamichi Y, Funayama M, Mizuno Y, Hattori N, Kuzuhara S
    • Journal Title

      Mov Disord 23

      Pages: 2344-2348

    • Data Source
      KAKENHI-PROJECT-19390244

  • [Journal Article] Wireless voltammetry recording in unanesthetised behaving rats2008
    • Author(s)
      Kagohashi M, Nakazato T, Yoshimi K, Moizumi S, Hattori N, Kitazawa S
    • Journal Title

      Neurosci Res 60

      Pages: 120-7

    • Data Source
      KAKENHI-PROJECT-19390244

  • [Journal Article] Visual impairment in Parkinson's disease treated with amantadine : Case report and review of the literature2008
    • Author(s)
      Kubo, S., Iwatake, A., Ebihara, N., Murakami, A., Hattori, N
    • Journal Title

      Parkinsonism Relat Disord 14

      Pages: 166-169

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590956

  • [Journal Article] Mutation analyses in amyotrophic lateral sclerosis/parkinsonism-dementia complex of the Kii peninsula, Japan.2008
    • Author(s)
      Tomiyama H, Kokubo Y, Sasaki R, Li Y, Imamichi Y, Funayama M, Mizuno Y, Hattori N, Kuzuhara S
    • Journal Title

      Mov Disord 23

      Pages: 2344-2348

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390239

  • [Journal Article] Familial Parkinsonism with digenic parkin and PINK1 mutations.2008
    • Author(s)
      Funayama M, Li Y, Tsoi TH, Lam CW, Ohi T, Yazawa S, Uyama E, Djaldetti R, Melamed E, Yoshino H, Imamichi Y, Takashima H, Nishioka K, Sato K, Tomiyama H, Kubo S, Mizuno Y, Hattori N
    • Journal Title

      Mov Disord 23

      Pages: 1461-1465

    • Data Source
      KAKENHI-PROJECT-20591010

  • [Journal Article] Mutation analyses in amyotrophic lateral sclerosis/parkinsonism-dementia complex of the Kii peninsula, Japan2008
    • Author(s)
      Tomiyama H, Kokubo Y, Sasaki R, Li Y, Imamichi Y, Funayama M, Mizuno Y, Hattori N, Kuzuhara S
    • Journal Title

      Mov Disord 23

      Pages: 2344-2348

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390239

  • [Journal Article] LRRK2 P755L variant in sporadic Parkinson's disease.2008
    • Author(s)
      Tomiyama H, Mizuta I, Li Y, Funayama M, Yoshino H, Li L, Murata M, Yamamoto M, Kubo S, Mizuno Y, Toda T, Hattori N
    • Journal Title

      J Hum Genet 53

      Pages: 1012-1015

    • NAID

      10025584966

    • Data Source
      KAKENHI-PROJECT-20591010

  • [Journal Article] PARK2 mutations and clinical features in a Chinese population with early-onset Parkinson's disease2008
    • Author(s)
      Chan DK, Mok V, Ng PW, Yeung J, Kwok JB, Fang ZM, Clarke R, Wong L, Schofield PR, Hattori N
    • Journal Title

      J Neural Transm 115

      Pages: 715-9

    • Data Source
      KAKENHI-PROJECT-19390244

  • [Journal Article] Animal models of Parkinson's disease : similarities and differences between the disease andmodels2008
    • Author(s)
      Hattori N, Sato S
    • Journal Title

      Neuropathology 27

      Pages: 479-83

    • Data Source
      KAKENHI-PROJECT-19390244

  • [Journal Article] PARK9-linked parkinsonism in Eastern Asia : Mutation detection in ATP13A2 andclinical phenotype2008
    • Author(s)
      Ning Y, Kanai K, Tomiyama H, Li Y, Funayama M, Yoshino H, Sato S, Asahina M, Kuwabara S, Takeda A, Hattori T, Mizuno Y, Hattori N
    • Journal Title

      Neurology 70

      Pages: 1491-1493

    • Data Source
      KAKENHI-PROJECT-19390244

  • [Journal Article] Visual impairment in Parkinson's disease treated with amantadine : case report and review of the literature2008
    • Author(s)
      Kubo S, Iwatake A, Ebihara N, Murakami A, Hattori N
    • Journal Title

      Parkinsonism Relat Disord 14(2)

      Pages: 166-9

    • Data Source
      KAKENHI-PROJECT-19390244

  • [Journal Article] LRRK2 G2385R variant is a risk factor for Parkinson disease in Asian population2007
    • Author(s)
      Funayama M, Hattori N, et al.
    • Journal Title

      NeuroReport 18

      Pages: 273-275

    • Data Source
      KAKENHI-PROJECT-19390244

  • [Journal Article] Neuropsychiatric and cognitive features in autosomal-recessive early parkinsonism due to PINK1 mutations2007
    • Author(s)
      Ephraty L, Porat O, Israeli D, Cohen OS, Tunkel O, Yael S, Hatano Y, Hattori N, Hassin-Baer S
    • Journal Title

      Mov Disord 22

      Pages: 566-569

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390256

  • [Journal Article] Leucine-rich repeat kinase 2 associates with lipid rafts2007
    • Author(s)
      Hatano T, Hattori N, et al.
    • Journal Title

      Human Mol Genet 16

      Pages: 678-690

    • Data Source
      KAKENHI-PROJECT-19390244

  • [Journal Article] Correlation between levels of pigment epithelium-derived factor and vascular endothelial growth factor in the striatum of patients with Parkinson's disease2007
    • Author(s)
      Yasuda T, Fukuda-Tani M, Nihira T, Wada K, Hattori N, Mizuno Y, Mochizuki H
    • Journal Title

      Exp Neurol 206

      Pages: 308-17

    • Data Source
      KAKENHI-PROJECT-19390244

  • [Journal Article] Parkinson's disease : a hint to elucidate the mechanisms of nigral degeneration.2007
    • Author(s)
      Ihara M, Yamasaki N, Hagiwara A, Tanigaki A, Kitano A, Hikawa R, Tomimoto H, Noda M, Takanashi M, Mori H, Hattori N, Miyakawa T, Kinoshita M, Familial
    • Journal Title

      Neuron 53

      Pages: 519-533

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390256

  • [Journal Article] Mitochondrial dysfunction in Parkinson's disease2007
    • Author(s)
      Fukae J, Mizuno Y, Hattori N
    • Journal Title

      Mitochondrion 7

      Pages: 58-62

    • NAID

      40021018096

    • Data Source
      KAKENHI-PROJECT-19390244

  • [Journal Article] LRRK2 G2385R variant is a risk factor for Parkinson disease in Asian population2007
    • Author(s)
      Funayama M, Li Y, Tomiyama H, Yoshino H, Imamichi Y, Yamamoto M, Murata M, Toda T, Mizuno Y, Hattori N
    • Journal Title

      Neuroreport 18

      Pages: 273-275

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390256

  • [Journal Article] LRRK2 G2385R variant is a risk factor for Parkilson disease in Asian population2007
    • Author(s)
      Funayama, M・Hattori, N, et. al.
    • Journal Title

      NeuroReport 18

      Pages: 273-275

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19044040

  • [Journal Article] Sept4, a component of presynaptic Scaffold and Lewy bodies, is required for the suppression of alpha-synuclein neurotoxicity2007
    • Author(s)
      Ihara, M・Hattori, N, et. al.
    • Journal Title

      Neuron 53

      Pages: 519-533

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19044040

  • [Journal Article] Fibroblast growth factor 20 gene and Parkinson's disease in the Japanese population2007
    • Author(s)
      Satake W, Mizuta I, Suzuki S, Nakabayashi Y, Ito C, Watanabe M, Takeda A, Hasegawa K, Sakoda S, Yamamoto M, Hattori N, Murata M, Toda T
    • Journal Title

      Neuroreport 18

      Pages: 937-40

    • Data Source
      KAKENHI-PROJECT-19390244

  • [Journal Article] Sept4, a Component of Presynaptic Scaffold and Lewy Bodies, Is Required for the Suppression of alpha-Synuclein Neurotoxicity.2007
    • Author(s)
      Ihara M, Yamasaki N, Hagiwara A, Tanigaki A, Kitano A, Hikawa R, Tomimoto H, Noda M, Takanashi M, Mori H, Hattori N, Miyakawa T, Kinoshita M.
    • Journal Title

      Neuron 53

      Pages: 519-533

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390256

  • [Journal Article] Screening for Lrrk2 G2019S and clinical comparison of Tunisian and North American Caucasian Parkinson's disease families2007
    • Author(s)
      Ishihara L, Gibson RA, Warren L, Amouri R, Lyons K, Wielinski C, Hunter C, Swartz JE, Elango R, Akkari PA, Leppert D, Surh L, Reeves KH, Thomas S, Ragone L, Hattori N, Pahwa R, Jankovic J, Nance M, Freeman A, Gouider-Khouja N, Kefi M, Zouari M, Ben Sassi S, Ben Yahmed S, El Euch-Fayeche G, Middleton L, Burn DJ, Watts RL, Hentati F
    • Journal Title

      Mov Disord 22

      Pages: 55-61

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390256

  • [Journal Article] Leucine-rich repeat kinase 2 associates with lipid rafts2007
    • Author(s)
      Hatano, T., Kubo, S., Imai, S., Maeda, M., Ishikawa, K., Mizuno, Y., Hattori, N
    • Journal Title

      Hum Mol Genet 16

      Pages: 678-690

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590956

  • [Journal Article] Screening for Lrrk2 G2019S and clinical comparison of Tunisian and North American Caucasian Parkinson's disease families.2007
    • Author(s)
      Ishihara L, Gibson RA, Warren L, Amouri R, Lyons K, Wielinski C, Hunter C, Swartz JE, Elango R, Akkari PA, Leppert D, Surh L, Reeves KH, Thomas S, Ragone L, Hattori N, Pahwa R, Jankovic J, Nance M, Freeman A, Gouider-Khouja N, Kefi M, Zouari M, Ben Sassi S, Ben Yahmed S, El Euch-Fayeche G, Middleton L, Burn DJ, Watts RL, Hentati F
    • Journal Title

      Mov Disord 22

      Pages: 55-61

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390256

  • [Journal Article] Fabrication, characterization, and application of boron-doped diamond microelectrodes for in vivo dopamine detection2007
    • Author(s)
      Suzuki A, Ivandini TA, Yoshimi K, Fujishima A, Oyama G, Nakazato T, Hattori N, Kitazawa S, Einaga Y
    • Journal Title

      Anal Chem 79

      Pages: 8608-15

    • Data Source
      KAKENHI-PROJECT-19390244

  • [Journal Article] Screening for Lrrk2 G2019S and clinical comparison of Tunisian and North American Caucasian Parkinson's disease families.2007
    • Author(s)
      Ishihara L, Gibson RA, Warren L, Amouri R, Lyons K, Wielinski C, Hunter C, Swartz JE, Elango R, Akkari PA, Leppert D, Surh L, Reeves KH, Thomas S, Ragone L, Hattori N, Pahwa R, Jankovic J, Nance M, Freeman A, Gouider-Khouja N, Kefi M, Zouari M, Ben Sassi S, Ben Yahmed S, El Euch-Fayeche G, Middleton L, Burn DJ, Watts RL, Hentati F.
    • Journal Title

      Mov Disord 22

      Pages: 55-61

    • Data Source
      KAKENHI-PROJECT-17390256

  • [Journal Article] Sept4,a component of presynaptic Scaffold and Lewy bodies,is required for the suppression of alpha-synuclein neurotoxicity2007
    • Author(s)
      Ihara M., Hattori N., et. al.
    • Journal Title

      Neuron 53

      Pages: 519-533

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390244

  • [Journal Article] Fibroblast growth factor 20 gene and Parkinson's disease in the Japanese population2007
    • Author(s)
      Satake W, Mizuta I, Suzuki S, Nakabayashi Y, Ito C, Watanabe M, Takeda A, Hasegawa K, Sakoda S, Yamamoto M, Hattori N, Murata M, Toda T.
    • Journal Title

      Neuroreport 18

      Pages: 937-940

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019044

  • [Journal Article] Dopaminergic neuronal dysfunction associated with parkinsonism in both a Gaucher disease patient and a carrier2007
    • Author(s)
      Kono S, Shirakawa K, Ouchi Y, Sakamoto M, Ida H, Sugiura T, Tomiyama H, Suzuki H, Takahashi Y, Miyajima H, Hattori N, Mizuno Y
    • Journal Title

      J Neurol Sci 252

      Pages: 181-184

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390256

  • [Journal Article] Leucine-rich repeat kinase 2 associates with lipid rafts2007
    • Author(s)
      Hatano T, Kubo SI, Imai S, Maeda M, Ishikawa K, Mizuno Y, Hattori N
    • Journal Title

      Hum Mol Genet 16

      Pages: 678-690

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390256

  • [Journal Article] Parkin is expressed in vascular endothelial cells2007
    • Author(s)
      Tamo W, Imaizumi T, Tanji K, Yoshida H, Takanashi S, Wakabayashi K, Takahashi R, Hattori N, Satoh K
    • Journal Title

      Neurosci Lett 419

      Pages: 199-201

    • Data Source
      KAKENHI-PROJECT-19390244

  • [Journal Article] Leucine-rich repeat kinase 2 associates with lipid rafts2007
    • Author(s)
      Hatano, T・Hattori, N, et. al.
    • Journal Title

      Human Mol Genet 16

      Pages: 678-690

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19044040

  • [Journal Article] Focal cerebral ischemia/reperfusion injury in mice induces hematopoietic prostaglandin D synthase in microglia and macrophages.2007
    • Author(s)
      Liu M, Eguchi N, Yamasaki Y, Urade Y, Hattori N, Urabe T
    • Journal Title

      Neuroscience 145

      Pages: 520-529

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590897

  • [Journal Article] Dopaminergic neuronal dysfunction associated with parkinsonism in both a Gaucher disease patient and a carrier2007
    • Author(s)
      Kono S, Shirakawa K, Ouchi Y, Sakamoto M, Ida H, Sugiura T, Tomiyama H, Suzuki H, Takahashi Y, Miyajima H, Hattori N, Mizuno Y
    • Journal Title

      J Neurol Sci 252

      Pages: 181-4

    • Data Source
      KAKENHI-PROJECT-19390244

  • [Journal Article] Neuropsychiatric and cognitive features in autosomal-recessive early parkinsonism due to PINK1 mutations2007
    • Author(s)
      Hatano T, Kubo SI, Imai S, Maeda M, Ishikawa K, Mizuno Y, Hattori N
    • Journal Title

      Hum Mol Genet Mar 6 (epub ahead of print)

    • Data Source
      KAKENHI-PROJECT-17390256

  • [Journal Article] Leucine-rich repeat kinase 2 associates with lipid rafts2007
    • Author(s)
      Hatano T., Hattori N., et. al.
    • Journal Title

      Human Mol Genet 16

      Pages: 678-690

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390244

  • [Journal Article] Neuropsychiatric and cognitive features in autosomal-recessive early parkinsonism due to PINK1 mutations2007
    • Author(s)
      Ephraty L, Porat O, Israeli D, Cohen OS, Tunkel O, Yael S, Hatano Y, Hattori N, Hassin-Baer S
    • Journal Title

      Mov Disord 22

      Pages: 566-9

    • Data Source
      KAKENHI-PROJECT-19390244

  • [Journal Article] Neuropsychiatric and cognitive features in autosomal-recessive early parkinsonism due to PINK1 mutations2007
    • Author(s)
      Ephraty L, Porat O, Israeli D, Cohen OS, Tunkel O, Yael S, Hatano Y, Hattori N, Hassin-Baer S
    • Journal Title

      Mov Disord Jan 26 (Epub ahead of print)

    • Data Source
      KAKENHI-PROJECT-17390256

  • [Journal Article] Dopaminergic neuronal dysfunction associated with parkinsonism in both a Gaucher disease patient and a carrier2007
    • Author(s)
      Kono S, Shirakawa K, Ouchi Y, Sakamoto M, Ida H, Sugiura T, Tomiyama H, Suzuki H, Takahashi Y, Miyajima H, Hattori N, Mizuno Y.
    • Journal Title

      J Neurol Sci 252

      Pages: 181-184

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390256

  • [Journal Article] Decline of striatal dopamine release in parkin-deficient mice shown by ex vivo autoradiography2007
    • Author(s)
      Sato S, Chiba T, Nishiyama S, Kakiuchi T, Tsukada H, Hatano T, Fukuda T, Yasoshima Y, Kai N, Kobayashi K, Mizuno Y, Tanaka K, Hattori N
    • Journal Title

      J Neurosci Res 84

      Pages: 1350-1357

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390256

  • [Journal Article] Sept4. a Component of Presynaptic Scaffold and Lewy Bodies, Is Required for the Suppression of alpha-Synuclein Neurotoxicity2007
    • Author(s)
      Ihara M, Yamasaki N, Hagiwara A, Tanigaki A, Kitano A, Hikawa R, Tomimoto H, Noda M, Takanashi M, Mori H, Hattori N, Miyakawa T, Kinoshita M
    • Journal Title

      Neuron 53

      Pages: 519-33

    • Data Source
      KAKENHI-PROJECT-19390244

  • [Journal Article] LRRK2 G2385R variant is a risk factor for parkinson disease in Asian population.2007
    • Author(s)
      Funayama M, Li Y, Tomiyama H, Yoshino H, Imamichi Y, Yamamoto M, Murata M, Toda T, Mizuno Y, Hattori N.
    • Journal Title

      Neuroreport 18

      Pages: 273-275

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019044

  • [Journal Article] Induction and selective accumulation of mutant ubiquitin in CA1 pyramidal neurons after transient global ischemia.2007
    • Author(s)
      Yamashiro K, Liu R, Maeda M, Hattori N, Urabe T
    • Journal Title

      Neuroscience (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590897

  • [Journal Article] Sept4, a Component of Presynaptic Scaffold and Lewy Bodies, Is Required for the Suppression of alpha-Synuclein Neurotoxicity.2007
    • Author(s)
      Ihara, M・Yamasaki, N・Hagiwara, A・Tanigaki, A・Kitano, A・Hikawa, R・Tomimoto, H・Noda, M・Takanashi, M・Mori, H・Hattori, N・Miyakawa, T・Kinoshita, M.
    • Journal Title

      Neuron 53

      Pages: 519-33

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17025037

  • [Journal Article] Leucine-rich repeat kinase 2 G2385R variant is a risk factor for Parkinson disease in Asian population2007
    • Author(s)
      Funayama M, Li Y, Tomiyama H, Yoshino H, Imamichi Y, Yamamoto M, Murata M, Toda T, Mizuno Y, Hattori N
    • Journal Title

      Neuroreport 18

      Pages: 273-5

    • Data Source
      KAKENHI-PROJECT-19390244

  • [Journal Article] Sept4, a component of presynaptic Scaffold and Lewy bodies, is required for the suppression of alpha-synuclein neurotoxicity2007
    • Author(s)
      Ihara M, , Hattori N, et al.
    • Journal Title

      Neuron 53

      Pages: 519-533

    • Data Source
      KAKENHI-PROJECT-19390244

  • [Journal Article] Prognosis of Parkinson's disease : time to stage III, IV, V, and to motor fluctuations2007
    • Author(s)
      Sato K, Hatano T, Yamashiro K, Kagohashi M, Nishioka K, Izawa N, Mochizuki H, Hattori N, Mori H, Mizuno Y
    • Journal Title

      Mov Disord 21

      Pages: 1384-1395

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390256

  • [Journal Article] LRRK2 G2385R variant is a risk factor for Parkinson disease in Asianpopulation2007
    • Author(s)
      Funayama M., Hattori N., et. al.
    • Journal Title

      NeuroReport 18

      Pages: 273-275

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390244

  • [Journal Article] Screening for Lrrk2 G2019S and clinical comparison of Tunisian and North American Caucasian Parkinson's disease families2007
    • Author(s)
      Ishihara L, Gibson RA, Warren L, Amouri R, Lyons K, Wielinski C, Hunter C, Swartz JE, Elango R, Akkari PA, Leppert D, Surh L, Reeves KH, Thomas S, Ragone L, Hattori N, Pahwa R, Jankovic J, Nance M, Freeman A, Gouider-Khouja N, Kefi M, Zouari M, Ben Sassi S, Ben Yahmed S, ElEuch-Fayeche G, Middleton L, Burn DJ, Watts RL, Hentati F
    • Journal Title

      Mov Disord 22

      Pages: 55-61

    • Data Source
      KAKENHI-PROJECT-19390244

  • [Journal Article] Leucine-rich repeat kinase 2 associates with lipid rafts2007
    • Author(s)
      Hatano, T・Kubo, S・Imai, S・Maeda, M・Ishikawa, K・Mizuno, Y・HattoriN
    • Journal Title

      Hum Mol Genet 16

      Pages: 678-690

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17025037

  • [Journal Article] Leucine-rich repeat kinase 2 associates with lipid rafts2007
    • Author(s)
      Hatano T, Kubo S, Imai S, Maeda M, Ishikawa K, Mizuno Y, Hattori N
    • Journal Title

      Hum Mol Genet 16

      Pages: 678-90

    • Data Source
      KAKENHI-PROJECT-19390244

  • [Journal Article] Decline of striatal dopamine release in parkin-deficient mice shown by ex vivo autoradiography2006
    • Author(s)
      Sato S, Chiba T, Nishiyama S, Kakiuchi T, Tsukaba H, Hatano T, Fukuda T, Yasoshima Y, Kai N, Kobayashi K, Mizuno Y, Tanaka K, Hattori N
    • Journal Title

      J Neurosci Res 84

      Pages: 1350-1357

    • Data Source
      KAKENHI-PROJECT-17390256

  • [Journal Article] Clinicogenetic study of mutations in LRRK2 exon 41 in Parkinson's disease patients from 18 countries.2006
    • Author(s)
      Tomiyama H, Li Y, Funayama M, Hasegawa K, Yoshino H, Kubo S, Sato K, Hattori T, Lu CS, Inzelberg R, Djaldetti R, Melamed E, Amouri R, Gouider-Khouja N, Hentati F, Hatano Y, Wang M, Imamichi Y, Mizoguchi K, Miyajima H, Obata F, Toda T, Farrer MJ, Mizuno Y, Hattori N.
    • Journal Title

      Mov Disord 21

      Pages: 1102-1108

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019044

  • [Journal Article] Molecular mechanisms of nigral neurodegeneration in Park2 and regulation of parkin protein by other proteins2006
    • Author(s)
      Hattori, N., Machida, Y., Sato, S., Noda, K., Iijima-Kitami, M., Kubo, S., Mizuno, Y
    • Journal Title

      J Neural Transm 70

      Pages: 205-208

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590956

  • [Journal Article] 14-3-3h is a novel regulator of parkin ubiquitin-ligase2006
    • Author(s)
      Sato S, Chiba, Tanaka K, T, Mizuno Y, Hattori N, et al.
    • Journal Title

      EMBOJ (In press)

    • Data Source
      KAKENHI-PROJECT-17025037

  • [Journal Article] Clinical heterogeneity of a-synuclein gene duplication in Parkinson's disease.2006
    • Author(s)
      Nishioka K, Hayashi S, Farrer MJ, Singleton AB, Yoshino H, Imai H, Kitami T, Sato K, Kuroda R, Tomiyama H, Mizoguchi K, Murata M, Toda T, Imoto I, Inazawa J, Mizuno Y, Hattori N.
    • Journal Title

      Ann Neurol 59

      Pages: 298-309

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019044

  • [Journal Article] Recessive Parkinson's disease2006
    • Author(s)
      Kubo, S., Hattori, N., Mizuno, Y
    • Journal Title

      Mov Disord 21

      Pages: 885-893

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590956

  • [Journal Article] Clinical heterogeneity of alpha-synuclein gene duplication in Parkinson's disease2006
    • Author(s)
      Nishioka K, Hayashi S, Farrer MJ, Singleton AB, Yoshino H, Imai H, Kitami T, Sato K, Kuroda R, Tomiyama H, Mizoguchi K, Murata M, Toda T, Imoto I, Inazawa J, Mizuno Y, Hattori N
    • Journal Title

      Ann Neurol 59

      Pages: 298-309

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390256

  • [Journal Article] Van Broeckhoven C, Collaborative analysis of alnha-synuclein gene promoter variability and Parkinson disease2006
    • Author(s)
      Maraganore DM, de Andrade M, Elbaz A, Farrer MJ, Ioannidis JP, Kruger R, Rocca WA, Schneider NK, Lesnick TG, Lincoln SJ, Hulihan MM, Aasly JO, Ashizawa T, Chartier-Harlin MC, Checkoway H, Ferrarese C, Hadjigeorgiou G Hattori N, Kawakami H, Lambert JC, Lynch T, Mellick GD, Papapetropoulos S, Parsian A, Quattrone A, Riess O, Tan EK
    • Journal Title

      JAMA 296

      Pages: 661-670

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390256

  • [Journal Article] Progress in familial Parkinson's disease2006
    • Author(s)
      Mizuno, Hattori, et al.
    • Journal Title

      J Neural Transm Suppl 70

      Pages: 191-204

    • NAID

      130003670526

    • Data Source
      KAKENHI-PROJECT-17025037

  • [Journal Article] Molecular mechanisms of nigral neurodegeneration in Park2 and regulation of parkin protein by other proteins2006
    • Author(s)
      Hattori N
    • Journal Title

      J Neural Transm 70

      Pages: 205-208

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590956

  • [Journal Article] Hassin-Baer S of alpha-synuclein gene duplication in Parkinson's disease, Neuropsychiatric and cognitive features in autosomal-recessive early parkinsonism due to PINK1 mutations2006
    • Author(s)
      Ephraty L, Porat 0, Israeli D, Cohen OS, Tunkel 0, Yael S, Hatano Y, Hattori N
    • Journal Title

      Mov Disord 59

      Pages: 298-309

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390256

  • [Journal Article] Prognosis of Parkinson's disease : time to stage III, IV, V, and to motor fluctuations.2006
    • Author(s)
      Sato K, Hatano T, Yamashiro K, Kagohashi M, Nishioka K, Izawa N, Mochizuki H, Hattori N, Mori H, Mizuno Y
    • Journal Title

      Mov Disord 21

      Pages: 1384-1395

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390256

  • [Journal Article] Molecular mechanisms of nigral neurodegeneration in Park2 and regulation of parkin protein by other proteins.2006
    • Author(s)
      Hattori N et al.
    • Journal Title

      J Neural Transm. 70

      Pages: 205-208

    • Data Source
      KAKENHI-PROJECT-18590956

  • [Journal Article] Dominant-negative effect of mutant valosin-containing protein in aggresome formation2006
    • Author(s)
      Kitami MI, Kitami T, Nagahama M, Tagaya M, Hori S, Kakizuka A, Mizuno Y, Hattori N
    • Journal Title

      FEBS Lett 580

      Pages: 474-478

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390256

  • [Journal Article] Recessive Parkinson's disease2006
    • Author(s)
      Kubo S, Hattori N, Mizuno Y
    • Journal Title

      Mov Disord. 21

      Pages: 885-893

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390256

  • [Journal Article] Diverse effects of pathogenic mutations of Parkin that catalyzes multiple monoubiquitylation in vitro2006
    • Author(s)
      Matsuda N, Kitami T, Suzuki T, Mizuno Y, Hattori N, Tanaka K
    • Journal Title

      J Biol Chem 281

      Pages: 3204-3209

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390256

  • [Journal Article] Bispecific antibodies against modified protein and DNA with oxidized lipids2006
    • Author(s)
      Akagawa M, Ito S, Toyoda K, Ishii Y, Tatsuda E, Shibata T, Kawai Y, Ishino K, Kishi Y, Adachi T, Tsubata T, Takasaki Y, Hattori N, Matsuda T, Uchida K
    • Journal Title

      Proc Natl Acad Sci USA 103

      Pages: 6160-6165

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390256

  • [Journal Article] Clinical features of Parkinson's patients with and without LRRK2 mutations2006
    • Author(s)
      Ishihara L, Gibson RA, Warren L, Amouri R, Lyons K, Wielinski C, Hunter C, Swartz JE, Elango R, Akkari A, Leppert D, Surh L, Reeves KH, Thomas S, Ragone L, Hattori N, Pahwa R, Jankovic J, Nance M, Freeman A, Gouider-Khouja N, Kefi M, Bouar M, Sassi SB, Yahmed SB, Euch-Fayeche EG, Middleton L, Burn DJ, Watts RL, 1 Hentati F
    • Journal Title

      Arch Neurol 63

      Pages: 1250-1254

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390256

  • [Journal Article] 14-3-3 eta is a novel regulator of parkin ubiquitin-ligase2006
    • Author(s)
      Sato S, Chiba T, Sakata E, Kato K, Mizuno Y, Hattori N, Tanaka K
    • Journal Title

      EMBO J 25

      Pages: 211-221

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390256

  • [Journal Article] Clinicogenetic study of mutations in LRRK2 exon 41 in Parkinson's disease patients from 18 countries2006
    • Author(s)
      Tomiyama H, Li Y, Funayama M, Hasegawa K, Yoshino H, Kubo S, Sato K, Hattori T, Lu C-S, Inzelberg R, Djaldetti R, Melamed E, Amouri R, Gouider-Khouja N, Hentati F, Hatano Y, Wang M, Imamichi Y, Mizoguchi K, Miyajima H, Obata F, Toda T, Farrer MJ, Mizuno Y, Hattori N
    • Journal Title

      Mov Disord 21

      Pages: 1102-1108

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390256

  • [Journal Article] Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson disease2006
    • Author(s)
      Maraganore DM, de Andrade M, Elbaz A, Farrer MJ, Ioannidis JP, Kruger R, Rocca WA, Schneider NK, Lesnick TG, Lincoin SJ, Hulihan MM, Aasly JO, Ashizawa T, Chartier-Harlin MC, Checkoway H, Ferrarese C, Hadjigeorgiou G, Hattori N, Kawakami H, Lambert JC, Lynch T, Mellick GD, Papapetropoulos S, Parsian A, Quattrone A, Riess O, Tann EK, Van Broeckhoven C
    • Journal Title

      JAMA 296

      Pages: 661-670

    • Data Source
      KAKENHI-PROJECT-17390256

  • [Journal Article] Multiple candidate gene analysis identifies alpha-synuclein as a susceptibility gene for sporadic Parkinson's disease2006
    • Author(s)
      Mizuta I, Satake W, Nakabayashi Y, Ito C, Suzuki S, Momose Y, Nagai Y, Oka A, Inoko H, Fukae J, Saito Y, Sawabe M, Murayama S, Yamamoto M, Hattori N, Murata M, Toda T
    • Journal Title

      Hum Mol Genet 15

      Pages: 1151-1158

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390256

  • [Journal Article] Multiple candidate gene analysis identifies a-synuclein as a susceptibility gene for sporadic Parkinson's disease.2006
    • Author(s)
      Mizuta I, Satake W, Nakabayashi Y, Ito C, Suzuki S, Momose Y, Nagai Y, Oka A, Inoko H, Fukae J, Saito Y, Sawabe M, Murayama S, Yamamoto M, Hattori N, Murata M, Toda T.
    • Journal Title

      Hum Mol Genet 15

      Pages: 1151-1158

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019044

  • [Journal Article] Recessive Parkinson's disease2006
    • Author(s)
      Kubo S, Hattori N, Mizuno Y
    • Journal Title

      Mov Disord 21

      Pages: 885-893

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390256

  • [Journal Article] Positive immunoreactivity for vesicular monoamine transporter 2 in Lewy bodies and Lewy neurites in substantia nigra2006
    • Author(s)
      Yamamoto S, Fukae J, Mori H, Mizuno Y, Hattori N
    • Journal Title

      Neurosci Lett 396

      Pages: 187-191

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390256

  • [Journal Article] Nuclear localization of the 20S proteasome subunit in Parkinson's disease2006
    • Author(s)
      Nakamura A, Kitami T, Mori H, Mizuno Y, Hattori N
    • Journal Title

      Neurosci Lett 406

      Pages: 43-48

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390256

  • [Journal Article] Nuclear localization of the 20S proteasome subunit in Parkinson's disease2006
    • Author(s)
      Nakamura A, Kitami T, Mori H, Mizuno Y, Hattori N
    • Journal Title

      Neurosci Lett 406 : 43-48, 2006 406

      Pages: 43-48

    • Data Source
      KAKENHI-PROJECT-17390256

  • [Journal Article] Positive immunoreactivity for vesicular monoamine transporter 2 in Lewy bodies and Lewy neurites in substantia nigra2006
    • Author(s)
      Yamamoto S, Fukae J, Mori H, Mizuno Y, Hattori N
    • Journal Title

      FEBS Lett 580

      Pages: 187-191

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390256

  • [Journal Article] Clinical features of Parkinson's patients with and without LRRK2 mutations2006
    • Author(s)
      Ishihara L, Gibson RA, Warren L, Amouri R, Lyons K, Wielinski C, Hunter C, Swartz JE, Elango R, Akkari A, Leppert D, Surh L, Reeves KH, Thomas S, Ragone L, Hattori N, Pahwa R, Jankovic J, Nance M, Freeman A, Gouider-Khouja N, Kefi M, Bouar M, Sassi SB, Yahmed SB, Euch-Fayeche EG, Middleton L, Burn DJ, Watts RL, I Hentati F
    • Journal Title

      Arch Neurol 63

      Pages: 1250-1254

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390256

  • [Journal Article] Decline of striatal dopamine release in parkin-deficient mice shown by ex vivo autoradiography2006
    • Author(s)
      Sato S, Chiba T, Nishiyama S, Kakiuchi T, Tsukada H, Hatano T, Fukuda T, YasoshimaY, Kai N, Kobayashi K, Mizuno Y, Tanaka K, Hattori N
    • Journal Title

      J Neurosci Res 84

      Pages: 1350-1357

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390256

  • [Journal Article] Clinicogenetic study of mutations in LRRK2 exon 41 in Parkinson's disease patients from 18 countries2006
    • Author(s)
      Tomiyama, H., Li, Y., Funayama, M., Hasegawa, K., Yoshino, H., Kubo, S., Sato, K., Hattori, T., Lu, CS., Inzelberg, R., Djaldetti, R., Melamed, E., Amouri, R., Gouider-Khouja, N., Hentati, F., Hatano, Y., Wang, M., Imamichi, Y., Mizoguchi, K., Miyajima, H., Obata, F., Toda, T., Farrer, MJ., Mizuno, Y., Hattori, N
    • Journal Title

      Mov Disord 21

      Pages: 1102-1108

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590956

  • [Journal Article] Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson disease2006
    • Author(s)
      Maraganore DM, de Andrade M, Elbaz A, Farrer MJ, Ioannidis JP, Kruger R, Rocca WA, Schneider NK, Lesnick TG, Lincoln SJ, Hulihan MM, Aasly JO, Ashizawa T, Chartier-Harlin MC, Checkoway H, Ferrarese C, Hadjigeorgiou G, Hattori N, Kawakami H, Lambert JC, Lynch T, Mellick GD, Papapetropoulos S, Parsian A, Quattrone A, Riess O, Tan EK, Van Broeckhoven C
    • Journal Title

      JAMA 296

      Pages: 661-670

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390256

  • [Journal Article] Phosphtorylated I κ kα is a component of Lewy body of Parkinson's disease.2005
    • Author(s)
      Noda K, Kitami T, Gai WP, Chegini F, Jensen PH, Fimura T, Murayama K, Tanaka K, Mizuno Y, Hattori N.
    • Journal Title

      Biom Biophy Res Commun 331

      Pages: 309-317

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13210122

  • [Journal Article] Clinicogenetic study of PINK1 mutations in autosomal recessive early-onset parkinsonism2005
    • Author(s)
      Li Y, Tomiyama H, Sato K, Hatano Y, Yoshino H, Atsumi M, Kitaguchi M, Sasaki S, Kawaguchi S, Miyajima H, Toda T, Mizuno Y, Hattori N.
    • Journal Title

      Neurology 64

      Pages: 1955-1957

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019044

  • [Journal Article] Preserved cardiac sympathetic nerve accounts for normal cardiac uptake of MIBG in PARK2.2005
    • Author(s)
      Orimo S, Hattori N, et al.
    • Journal Title

      Movement Disorders 20

      Pages: 1350-1353

    • Data Source
      KAKENHI-PROJECT-17390256

  • [Journal Article] Preserved myocardial [(123)I]metaiodobenzylguanidine uptake in autosomal recessive juvenile parkinsonism : First case report.2005
    • Author(s)
      Suzuki M, Hattori N, et al.
    • Journal Title

      Movement Disorders 20

      Pages: 634-636

    • Data Source
      KAKENHI-PROJECT-17390256

  • [Journal Article] Clinicogenetic study of PINK1 mutations in autosomal recessive early-onset parkinsonism2005
    • Author(s)
      Li Y, Tomiyama H, Mizuno Y, Hattori N, et al.
    • Journal Title

      Neurology 64

      Pages: 1955-1957

    • Data Source
      KAKENHI-PROJECT-17025037

  • [Journal Article] Dopaminergic dysfunction in unrelated, asymptomatic carriers of a single parkin mutation.2005
    • Author(s)
      Inzelberg R, Hattori N, et al.
    • Journal Title

      Neurology 65

      Pages: 1843-1843

    • Data Source
      KAKENHI-PROJECT-17390256

  • [Journal Article] Phosphorylated IkappaBalpha is a component of Lewy body of Parkinson's Disease2005
    • Author(s)
      Noda K, Kitami T, Mizuno Y, Hattori N, et al.
    • Journal Title

      Biochem Biophys Res Commun 331

      Pages: 309-317

    • Data Source
      KAKENHI-PROJECT-17025037

  • [Journal Article] Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress.2005
    • Author(s)
      Moore DJ, Hattori N et al.
    • Journal Title

      Human Molecular Genetics 14

      Pages: 71-84

    • Data Source
      KAKENHI-PROJECT-17390256

  • [Journal Article] The LRRK2 I2012T,G2019S, and I2020T mutations are rare in Taiwanese patients with sporadic Parkinson's disease.2005
    • Author(s)
      Lu CS, Hattori N, et al.
    • Journal Title

      Parkinsonism and Related Disorders 11

      Pages: 521-522

    • Data Source
      KAKENHI-PROJECT-17390256

  • [Journal Article] Genetic association analyses of PHOX2B and ASCL1 in neuropsychiatric disorders : evidence for association of ASCL1 with Parkinson's disease.2005
    • Author(s)
      Ide M, Hattori N, et al.
    • Journal Title

      Human Genetics 117

      Pages: 520-527

    • Data Source
      KAKENHI-PROJECT-17390256

  • [Journal Article] Novel PINK 1 mutations in early-onset parkinsonism.2004
    • Author(s)
      Hatano Y, Li Y, Sato K, Asakwa S, Yamamura Y, Tomiyama H, Yoshino H, Asahina M, Kobyshi S, Ng Ar, Rosals RL, Hassin-Bear S, Shinar Y, Lu CS, Shimizu N, Toda T, Mizuno Y, Hattori N.
    • Journal Title

      Ann Neuro 56

      Pages: 424-427

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13210122

  • [Journal Article] PARK6-linked autosomal recessive early-onset parkinsonism in Asian populations.2004
    • Author(s)
      Hatano Y, Hattori N, et al.
    • Journal Title

      Neurology 63

      Pages: 1482-1485

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390277

  • [Journal Article] Parkin attenuates manganese-induced dopaminergic cell death.2004
    • Author(s)
      Higashi Y, Hattori N, et al.
    • Journal Title

      J Neurochem. 89

      Pages: 1490-1497

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390277

  • [Journal Article] Pathogenetic mechanisms of parkin in Parkisnson's disease2004
    • Author(s)
      Hattori N, Mizuno Y
    • Journal Title

      Lancet 364

      Pages: 21-27

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390277

  • [Journal Article] UCHL1 is a Parkinson's disease susceptibility gene.2004
    • Author(s)
      Maraganore DM, Hattori N, et al.
    • Journal Title

      Ann Neurol. 55

      Pages: 512-521

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390277

  • [Journal Article] Novel PINK1 mutations in early-onset parkinsonism.2004
    • Author(s)
      Hatano Y, Hattori N et al.
    • Journal Title

      Ann Neurol 56

      Pages: 424-27

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390277

  • [Journal Article] PARK6-linked autosomal recessive early-onset parkinsonism In Asian populations.2004
    • Author(s)
      Hatano Y, Sato K, Elibol B, Yoshino H, Yamamura Y, Bonifati V Shinotoh H, Asahina M, Kobayshi S, Ng Ar, RosalesRL, Hassin-Bear S, Shinar Y, Lu CS, Chang HC, Wu Chou Y, Atac FB, Kobayashi T, Toda T, Mizuno Y, Hattori N.
    • Journal Title

      Neurology 63

      Pages: 1482-1485

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13210122

  • [Journal Article] Parkin attenuates manganese-induced dopaminergic cell death.2004
    • Author(s)
      Higashi Y, Hattori N, et al.
    • Journal Title

      Journal of Neurochemistry 89

      Pages: 1490-1497

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390277

  • [Journal Article] Pathogenetic mechanisms of parkin in Parkinson's disease.2004
    • Author(s)
      Hattori N, Mizuno Y.
    • Journal Title

      Lancet 364

      Pages: 722-724

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13210122

  • [Journal Article] Pathogenetic mechanisms of parkin in Parkinson's disease.2004
    • Author(s)
      Hattori N et al.
    • Journal Title

      Lancet 364

      Pages: 722-724

    • Data Source
      KAKENHI-PROJECT-13210122

  • [Journal Article] Pathogenetic mechanisms of parkin in Parkinson's disease2004
    • Author(s)
      Hattori N, Mizuno Y
    • Journal Title

      Lancet 364

      Pages: 722-724

    • Data Source
      KAKENHI-PROJECT-15390277

  • [Journal Article] Novel PINK1 mutations in early-onset parkinsonism2004
    • Author(s)
      Hatano Y, Hattori N et al.
    • Journal Title

      Ann Neurol 56

      Pages: 424-427

    • Data Source
      KAKENHI-PROJECT-15390277

  • [Journal Article] PARK6-linked autosomal recessive early-onset parkinsonism in Asian populations2004
    • Author(s)
      Hatano Y, Hattori N, et al.
    • Journal Title

      Neurology 63

      Pages: 1482-1485

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390277

  • [Journal Article] Ubiquitin, proteasome and parkin.2004
    • Author(s)
      Tanaka K, Suzuki T, Hattori N, Mizuno Y.
    • Journal Title

      Biochim Biophys Acta 29 1695

      Pages: 235-247

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13210122

  • [Journal Article] Parkin and endoplasimic reticulum stress.2004
    • Author(s)
      Takahashi R, Imai Y, Hattori N, Mizuno Y.
    • Journal Title

      Ann NY Acad Sci 99

      Pages: 101-106

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13210122

  • [Journal Article] Parkin and endoplasimic reticulum stress2004
    • Author(s)
      Takahashi R, Hattori N, et al.
    • Journal Title

      Ann NY Acad Sci 99

      Pages: 101-106

    • Data Source
      KAKENHI-PROJECT-15390277

  • [Journal Article] Parkin attenuates manganese-induced dopaminergic cell death.2004
    • Author(s)
      Higashi Y, Asanuma M, Miyazaki I, Hattori N, Mizuno Y, Ogawa N.
    • Journal Title

      J Biol Chem 89(6)

      Pages: 1490-1497

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13210122

  • [Journal Article] Pathogenetic mechanisms of parkin in Parkisnosn's disease.2004
    • Author(s)
      Hattori N, Mizuno Y
    • Journal Title

      Lancet 364

      Pages: 722-724

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390277

  • [Journal Article] Parkin attenuates manganese-induced dopaminergic cell death.2004
    • Author(s)
      Higashi Y, Hattori N, et al.
    • Journal Title

      J Neurochem 89

      Pages: 1490-1497

    • Data Source
      KAKENHI-PROJECT-15390277

  • [Journal Article] Ubiquitin, proteasome and parkin2004
    • Author(s)
      Tanaka K, Suzuki T, Hattori N, Mizuno Y
    • Journal Title

      Biochim Biophys Acta 1695

      Pages: 235-247

    • Data Source
      KAKENHI-PROJECT-15390277

  • [Journal Article] Novel PINK1 mutations in early-onset parkinsonism2004
    • Author(s)
      Hatano Y, Hattori N et al.
    • Journal Title

      Annals of Neurology 56

      Pages: 424-427

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390277

  • [Journal Article] PARK6-linked autosomal recessive early-onset parkinsonism in Asian populations.2004
    • Author(s)
      Hatano Y, Hattori N et al.
    • Journal Title

      Neurology 63

      Pages: 1482-1485

    • Data Source
      KAKENHI-PROJECT-15390277

  • [Journal Article] Pathogenetic mechanisms of parkin in Parkinson's disease2004
    • Author(s)
      Hattori N, Mizuno Y
    • Journal Title

      Lancet 364

      Pages: 722-724

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13210122

  • [Journal Article] Familial Parkinson's disease : a hint to elucidate the mechanisms of nigral degeneration2003
    • Author(s)
      Hattori N, et al.
    • Journal Title

      Journal of Neurology 250(Suppl3)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390277

  • [Journal Article] Familial Parkinson's disease : a hint to elucidate the mechanisms of nigral degeneration2003
    • Author(s)
      Nobutaka Hattori
    • Journal Title

      Journal of Neurology 250(Suppl3)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590909

  • [Journal Article] Parkin cleaves intracellular alpha-synuclein inclusions via the activation of calpain.2003
    • Author(s)
      Kim SJ, Sung JY, Urn JW, Hattori N, Mizuno Y, Tanaka K, Paik SR, Kim J, Chung KC.
    • Journal Title

      J Biol Chem. 278

      Pages: 41890-41899

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13210122

  • [Journal Article] Familial Parkinson's disease : a hint to elucidate the mechanisms of nigral degeneration2003
    • Author(s)
      Nobutaka Hattori
    • Journal Title

      Journal of Neurology 250 (Suppl3)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590909

  • [Journal Article] Haploinsufficiency at the a-synuclein gene underlies phenotypic severity in familial Parkinson's disease.2003
    • Author(s)
      Kobayashi H, Kruger R, Markopoulou K, Wszolek Z, Chase B, Taka H, Mineki R, Murayama K, Riess O, Mizuno Y, Hattori N.
    • Journal Title

      Brain. 126(Pt 1)

      Pages: 32-42

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13210122

  • [Journal Article] Familial Parkinson's disease : a hint to elucidate the mechanisms of nigral degeneration.2003
    • Author(s)
      Hattori N, et al.
    • Journal Title

      J Neurol 205[suppl3]

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390277

  • [Journal Article] Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies.2002
    • Author(s)
      Schossmacher MG, Frosch MP, Ping-Gai W, Medina M, Sharma N, Forno L, Ochiishi T, Shimura H, Sharon R, Hattori N, Langston JW, Mizuno Y, Hyman BT, Selkoe DJ, Kosik K.
    • Journal Title

      Am J Pathol 160

      Pages: 1655-1667

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13210122

  • [Journal Article] Effect of wild-type or mutant Parkin on oxidative damage nitic oxide antioxidant defenses, and the proteasome.2002
    • Author(s)
      Hyun DH, Lee M, Hattori N, Kubo S, Mizuno Y, Halliwell B, Jenner P.
    • Journal Title

      J Biol Chem 277(32)

      Pages: 28572-28577

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13210122

  • [Journal Article] An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of parkin.2001
    • Author(s)
      Imai Y, Soda M, Inoue H, Hattori N, Mizuno Y, Takahashi R.
    • Journal Title

      Cell 105

      Pages: 891-902

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13210122

  • [Journal Article] Parkin and Parkinson's disease.2001
    • Author(s)
      Mizuno Y, Hattori N, Mori H, Suzuki T, Tanaka K.
    • Journal Title

      Curr Opin Neurol 14

      Pages: 477-482

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13210122

  • [Journal Article] Parkin is associated with cellular vesicles.2001
    • Author(s)
      Kubo S, Kitami T, Noda S, Shimura H, Uchiyama Y, Asakawa S, Minoshima S, Shimizu N, Mizuno Y, Hattori N.
    • Journal Title

      J Neruochem 78

      Pages: 42-54

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13210122

  • [Journal Article] Developmental changes in the expression of parkin and UbcR7, a parkin-interacting and ubiquitin-conjugating enzyme, in rato brain.2001
    • Author(s)
      Wang M, Suzuki T, Kitada T, Asakawa S, Minoshima S, Shimizu N, Tanaka K, Mizuno Y, Hattori N.
    • Journal Title

      J Neurochem 77

      Pages: 1561-1568

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13210122

  • [Journal Article] Parkin is linked to the ubiquitin pathway.2001
    • Author(s)
      Tanaka K, Suzuki T, Chiba T, Shimura H, Hattori N, Mizuno Y.
    • Journal Title

      J Mol Med 79

      Pages: 482-494

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13210122

  • [Journal Article] Parkin and Parkinson's disease.2001
    • Author(s)
      Mizuno Y, Hattori N, Mori H, Suzuki T, Tanaka K
    • Journal Title

      Curr Opin Neurol 14

      Pages: 477-482

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13210122

  • [Journal Article] An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of parkin.2001
    • Author(s)
      Imai Y, Soda M, Inoue H, Hattori N, Mizuno Y, Takahashi R
    • Journal Title

      Cell 105

      Pages: 891-902

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13210122

  • [Journal Article] Ubiquitination of a new form of a-synuclein by parkin from Human brain : Implications for Parkinson's disease.2001
    • Author(s)
      Shimura H, Schlossmacher MG, Hattori N, Frosch MP, Trockenbacher A, Schneider R, Mizuno Y, Kosik KS, Selkoe DJ.
    • Journal Title

      Science 293

      Pages: 263-269

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13210122

  • [Journal Article] Clinicogenetic study of PINK1 mutations in autosomal recessive early-onset parkinsonism
    • Author(s)
      Yuanzhe Li, Nobutaka Hattori et al.
    • Journal Title

      Neurology (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390277

  • [Journal Article] Clinicogenetic study of PINK1 mutations in autosomal recessive early-onset parkinsonism.
    • Author(s)
      Yuanzhe Li, Nobutaka Hattori et al.
    • Journal Title

      Neurology (In press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390277

  • [Journal Article] Pseudo-heterozygous rearrangement mutation of parkin
    • Author(s)
      Funayama M, Yoshino H, Li Y, Kusaka H, Tomiyama H, Hattori N
    • Journal Title

      Mov Disord

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591098

  • [Patent] パーキンソン病の重症度判定方法2016
    • Inventor(s)
      服部信孝、斉木臣二ら
    • Industrial Property Rights Holder
      服部信孝、斉木臣二ら
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-10-27
    • Data Source
      KAKENHI-PLANNED-25111007

  • [Patent] パーキンソン病予防治療薬剤2013
    • Inventor(s)
      服部信孝、斉木臣二、井本正哉、藤巻貴宏
    • Industrial Property Rights Holder
      服部信孝、斉木臣二、井本正哉、藤巻貴宏
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-04-25
    • Data Source
      KAKENHI-PLANNED-23111003

  • [Patent] パーキンソン病予防治療薬剤2013
    • Inventor(s)
      服部信孝、斉木臣二、井本正哉、藤巻貴宏
    • Industrial Property Rights Holder
      服部信孝、斉木臣二、井本正哉、藤巻貴宏
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-04-25
    • Data Source
      KAKENHI-PROJECT-24390224

  • [Patent] パーキンソン病モデルマウス及びその作製方法並びに該マウスを用いたパーキンソン病治療薬のスクリーニング方法及び評価方法2010
    • Inventor(s)
      岩井一宏、坂田真一、服部信孝
    • Acquisition Date
      2010-03-18
    • Data Source
      KAKENHI-PROJECT-20023028

  • [Patent] パーキンソン病モデルマウス及びその作製方法並びに該マウスを用いたパーキンソン病治療薬のスクリーニング方法及び評価方法2010
    • Inventor(s)
      岩井一宏, 坂田真一, 服部信孝
    • Industrial Property Rights Holder
      大阪大学順天堂大学
    • Acquisition Date
      2010-03-18
    • Overseas
    • Data Source
      KAKENHI-PROJECT-21390272

  • [Presentation] Updates on Parkinson’s disease management, Session Title: Personalised management of the diversities of non-motor symptoms in Parkinson’s disease2019
    • Author(s)
      Hattori N
    • Organizer
      2019 Chulalongkorn International Forum on Parkinson’s disease, Listening to patient’s concerns
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H04043

  • [Presentation] Genetic and clinical perspectives of young onset Parkinson’s disease, Pre-Congress Symposium II2018
    • Author(s)
      Hattori N.
    • Organizer
      The 4th Taiwan International Congress of Parkinson's Disease and Movement Disorders
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H04043

  • [Presentation] Genetics forms of PD: hints from them provide us concepts of pathogenesis of nigral degeneration, Homo Hundred Age & Dementia: Alzheimer's Parkinson's Disease、Symposium2018
    • Author(s)
      Hattori N．
    • Organizer
      32nd KAST International Symposium
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H04043

  • [Presentation] パーキンソン病の発症機序の解明（日本神経学会・楢林賞受賞者招待講演）2018
    • Author(s)
      服部信孝
    • Organizer
      第59回日本神経学会学術大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18H04043

  • [Presentation] Non-motor Complications of PD, Pathophysiology of OFF: Implications for Increasing, Recognition of Motor Fluctuations, Luncheon Seminar2018
    • Author(s)
      Hattori N.
    • Organizer
      International Parkinson and Movement Disorder Society, Hong Kong International Congress
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H04043

  • [Presentation] Promises of Induced Pluripotent Stem Cells: From Modeling to Therapy, presentation titled From Neurons to Brain Organoids2017
    • Author(s)
      Hattori N.
    • Organizer
      21st International Congress of Parkinson’s Disease and Movement Disorders 2017, Vancouver
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04842

  • [Presentation] PINK1-Parkinシグナル伝達に関与する新規分子の解析2017
    • Author(s)
      柴 佳保里、井下 強、青木 裕子、石濱 泰、今居 譲、服部信孝
    • Organizer
      ConBio2017
    • Data Source
      KAKENHI-PROJECT-26293070

  • [Presentation] 進化するパーキンソン病の病因解明研究2017
    • Author(s)
      服部信孝
    • Organizer
      第58回日本神経病理学会総会学術研究会、東京
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H04842

  • [Presentation] Advanced in the Genetics of Parkinson’s disease2017
    • Author(s)
      Hattori N. (Invited Speaker), Advanced in the Genetics of Parkinson’s disease, XXIII World Congress of Neurology, International conference center, Kyoto, Sept. 16th-21st, 2017, Kyoto, Japan
    • Organizer
      XXIII World Congress of Neurology 2017, Kyoto
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04842

  • [Presentation] Reduced TDP-43 expression improves axonal transport and synaptic activity in a Drosophila model of Perry syndrome2017
    • Author(s)
      Hosaka Y, Inoshita T, Cui C, Arano T, Shiba K, Imai Y, Hattori H
    • Organizer
      World Congress of Neurology
    • Data Source
      KAKENHI-PROJECT-26293070

  • [Presentation] Loss of Parkinson’s disease-associated protein CHCHD2 affects mitochondrial cristae structure and facilitates cytochrome c release from mitochondria2017
    • Author(s)
      Meng H, Yamashita C, Shiba-Fukushima K, Inoshita T, Imai Y, Hattori N
    • Organizer
      第40回日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-26293070

  • [Presentation] The Promise of Gene Based Technology in Movement Disorders, Hot Topic; Focusing on Genetics and Imaging in Movement Disorders2017
    • Author(s)
      Hattori N.
    • Organizer
      XXII World Congress on Parkinson’s Disease and Related Disorders 2017, Vietnam.
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04842

  • [Presentation] Symposist, Lysosomal enzyme欠損とパーキンソン病、シンポジウム1 PD治療はどこをめざすのか2017
    • Author(s)
      服部信孝
    • Organizer
      第11回パーキンソン病・運動障害疾患コングレス、東京
    • Data Source
      KAKENHI-PROJECT-15H04842

  • [Presentation] パーキンソン病に対する淡蒼球内節刺激術後のすくみ足の悪化．2017
    • Author(s)
      梅村淳，中島円，大山彦光，下泰司，中島明日香，城崇之，関本智子，中村亮太，佐々木扶悠子，伊藤賢伸，岩室宏一，服部信孝，新井一
    • Organizer
      第56回日本定位・機能神経外科学会
    • Place of Presentation
      大阪
    • Year and Date
      2017-01-27
    • Data Source
      KAKENHI-PROJECT-26462219

  • [Presentation] Treatment of Parkinson’s Disease, Plenary Session 12016
    • Author(s)
      Hattori N.
    • Organizer
      1st International Conference of Korean Movement Disorder Society KMDS
    • Place of Presentation
      Lotte Hotel Jeju, Jeju-do, South Korea
    • Year and Date
      2016-10-29
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04842

  • [Presentation] パーキンソン病新規原因遺伝子CHCHD2の機能解析2016
    • Author(s)
      山下 力、孟　紅蕊、井下強、福嶋佳保里、荒野拓、佐藤栄人、今居譲、服部信孝
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸市
    • Data Source
      KAKENHI-PROJECT-26293070

  • [Presentation] Mutations of mitochondrial protein CHCHD2 lead to parkinson’s disease-like phenotypes inDrosophil. ポスター発表2016
    • Author(s)
      Meng H, Yamashita C, Shiba-Fukushima K, Inoshita T, Funayama M, Sato S, Imai Y, Hattori N
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸コンベンションホール他、神戸
    • Year and Date
      2016-05-18
    • Data Source
      KAKENHI-PROJECT-15H04842

  • [Presentation] Evidence that phosphorylated ubiquitin signaling is involved in the etiology of Parkinson's disease2016
    • Author(s)
      Shiba-Fukushima K, Ishikawa K-I, Takanashi M, Akamatsu W, Imai Y, Hattori N
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      横浜市
    • Data Source
      KAKENHI-PROJECT-26293070

  • [Presentation] Synaptic vesicle dynamics are regulated by a subset of Parkinson’s disease genes2016
    • Author(s)
      Inoshita T, Cui C, Hattori N, Imai Y
    • Organizer
      第39回日本神経学会学術大会
    • Place of Presentation
      横浜市
    • Data Source
      KAKENHI-PROJECT-26293070

  • [Presentation] The analyze of four pedigrees with MAPT N279K mutation accompanying DAT scan and Tau imaging2016
    • Author(s)
      Aya Ikeda (Manabe), Kenya Nishioka, Yuanzhe Li, Hiroyo Yoshino, Manabu Funayama, Takashi Matsushima, Shinichi Ueno, Naohide Kurita, Hitoshi Shimada, Naruhiko Sahara, Makoto Higuchi, Tetsuya Suhara, Yuji Ueno, Masashi Takanashi, Yumiko Motoi, Nobutaka Hattori
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2016-05-18
    • Data Source
      KAKENHI-PROJECT-25860726

  • [Presentation] 小胞輸送と神経分泌を制御するパーキンソン病関連遺伝子のスクリーニング2016
    • Author(s)
      崔　長旭、井下　強、服部　信孝、今居　譲
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      横浜市
    • Data Source
      KAKENHI-PROJECT-26293070

  • [Presentation] Evidence that phosphorylated ubiquitin signaling is involved in the etiology of Parkinson’s disease.2016
    • Author(s)
      Shiba K, Ishikawa K, Inoshita T, Akamatsu W, Hideyuki O, Imai Y, Hattori N
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-26461280

  • [Presentation] 遺伝性パーキンソン病PARK9(ATP13A2)の分子病態とリソソームの障害、シンポジウム1AS19-42016
    • Author(s)
      佐藤栄人、小池正人、舩山 学、野田幸子、江崎淳二、福田隆浩、上野 隆、内山安男、服部信孝
    • Organizer
      パシフィコ横浜、横浜
    • Place of Presentation
      パシフィコ横浜、横浜
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-15H04842

  • [Presentation] Analysis of GCH1 mutations in the patients with Parkinson’s disease in Japanese population2016
    • Author(s)
      Kenya Nishioka, Hiroyo Yoshino, Takashi Matsushima, Aya Ikeda, Manabu Funayama, Nobutaka Hattori
    • Organizer
      11th Annual Meeting of the Genetic Epidemiology of Parkinson’s disease (GEOPD) Consortium
    • Place of Presentation
      Campus Belval, Luxembourg
    • Year and Date
      2016-10-06
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25860726

  • [Presentation] パーキンソン病原因遺伝子によるシナプス小胞動態制御、ポスター、5-a 高次生命現象・疾患 - 脳・神経系2016
    • Author(s)
      井下 強、荒野 拓、穂坂有加、孟 紅蕊、梅崎 勇次郎、小杉紗紀子、森本高子、小池正人、Hui-Yun Chang、今居 譲、服部信孝
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-15H04842

  • [Presentation] Parkinson's disease-associated mutations of PLA2G6 alters the membrane dynamics.2016
    • Author(s)
      Mori A, Imai Y, Hattori N
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸市
    • Data Source
      KAKENHI-PROJECT-26293070

  • [Presentation] パーキンソン病病態へのリン酸化ユビキチンシグナル関与の証拠、ポスター、5-i 高次生命現象・疾患 - 遺伝性疾患2016
    • Author(s)
      柴 佳保里、 石川景一、高梨 雅史、赤松 和土、今居 譲, 服部信孝
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-15H04842

  • [Presentation] CHCHD2 is Novel Causative Gene for Autosomal Dominant Parkinson's Disease, Symposium S1-B-3, Emerging genes for neurodegenerative diseases: a perspective on pathomechanisms2016
    • Author(s)
      Funayama M, Hattori N.
    • Organizer
      The 39th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Pacifico Yokohama, Yokohama
    • Year and Date
      2016-07-20
    • Data Source
      KAKENHI-PROJECT-15H04842

  • [Presentation] Dopamine transporrter scanで顕著な結合低下を示したN279Kタウ変異の前頭側頭葉変性症の5例2016
    • Author(s)
      竹重遥香、中山茶千子、林徹生、西岡健弥、波田野琢 、本井ゆみ子 、服部信孝
    • Organizer
      第57回　日本神経学会総会学術総会
    • Place of Presentation
      神戸コンベンションセンター、兵庫県
    • Year and Date
      2016-05-18
    • Data Source
      KAKENHI-PROJECT-26460921

  • [Presentation] Synaptic vesicle dynamics are regulated by Parkinson’s disease-associated proteins Vps35 and LRRK22016
    • Author(s)
      Inoshita T, Hosaka Y, Imai Y, Hattori N
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸コンベンションホール他、神戸
    • Year and Date
      2016-05-18
    • Data Source
      KAKENHI-PROJECT-15H04842

  • [Presentation] パーキンソン病原因遺伝子によるシナプス小胞動態制御2016
    • Author(s)
      井下　強、荒野　拓、穂坂　有加、孟　紅蕊、梅崎　勇次郎、小杉　紗紀子、森本　高子、小池　正人、Hui-Yun Chang、服部　信孝、今居　譲
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      横浜市
    • Data Source
      KAKENHI-PROJECT-26293070

  • [Presentation] Schizophrenia as a prodromal symptom in a patient harboring SNCA duplication2016
    • Author(s)
      Silvio Conedera, Aya Ikeda, Kenya Nishioka, Shogo Takamura, Takashi Matsushima, Yuanzhe Li, Hiroyo Yoshino, Manabu Funayama, Shigeru Morinobu, Nobutaka Hattori
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2016-05-18
    • Data Source
      KAKENHI-PROJECT-25860726

  • [Presentation] CHCHD2, a Parkinson's-Disease Associated Protein, Regulates the Mitochondrial cristae integrity and function in Drosophila2016
    • Author(s)
      Meng H, Yamashita C, Shiba-Fukushima K, Inoshita T, Imai Y, Hattori N
    • Organizer
      第39回日本神経学会学術大会
    • Place of Presentation
      横浜市
    • Data Source
      KAKENHI-PROJECT-26293070

  • [Presentation] In vivo evidence for the involvement of phospho-ubiquitin signal.2016
    • Author(s)
      Shiba K, Ishikawa K, Takanashi M, Akamatsu W, Imai Y, Hattori N
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-22
    • Data Source
      KAKENHI-PROJECT-26461280

  • [Presentation] Clinical; Gene products of monogenic forms for Parkinson's disease and their links to mitochondrial and protein degradation pathways2016
    • Author(s)
      Hattori N.
    • Organizer
      GEoPD(Genetic Epidemiology of Parkinson Disease), Luxembourg 2016, 11th Annual Meeting
    • Place of Presentation
      Univ. Luxembourg, Luxembourg
    • Year and Date
      2016-10-05
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04842

  • [Presentation] Based on the pathogenesis of Parkinson's disease (PD), the current therapeutic strategies for PD2016
    • Author(s)
      Hattori N.
    • Organizer
      5th memorial IBIC
    • Place of Presentation
      National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04842

  • [Presentation] 小胞輸送と神経分泌を制御するパーキンソン病関連遺伝子のスクリーニング、ポスター、5-a 高次生命現象・疾患 - 脳・神経系2016
    • Author(s)
      崔 長旭、井下 強、服部 信孝、今居 譲
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-15H04842

  • [Presentation] パーキンソン病に対する淡蒼球内節刺激術後のすくみ足の悪化．2016
    • Author(s)
      梅村淳，中島円，大山彦光，下泰司，中島明日香，城崇之，関本智子，中村亮太，伊藤賢伸，岩室宏一，服部信孝，新井一
    • Organizer
      社団法人日本脳神経外科学会　第75回学術総会
    • Place of Presentation
      福岡
    • Year and Date
      2016-09-29
    • Data Source
      KAKENHI-PROJECT-26462219

  • [Presentation] Genetics forms of Movement Disorders- hits from them provide us concepts of pathogenesis of nigral degeneration2016
    • Author(s)
      Hattori N.
    • Organizer
      MDS-AOS, Ambassador Program, Shanghai 2016( Fourth International Conference of PD and Movement Disorders Shanghai and the 2016 Ruijin International Congress in Shanghai
    • Place of Presentation
      Snangahi Jiao-Tong University, National Educational Depart., Shanghai, China
    • Year and Date
      2016-04-21
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04842

  • [Presentation] CHCHD2, a Parkinson's-Disease Associated Protein, Regulates the Mitochondrial cristae integrity and function in Drosophila, Oral O2-G-3-3, Movement Disorders2016
    • Author(s)
      Meng H, Yamashita C, Shiba K, Inoshita T, Imai Y, Hattori N.
    • Organizer
      The 39th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Yokohama, Yokohama
    • Year and Date
      2016-07-20
    • Data Source
      KAKENHI-PROJECT-15H04842

  • [Presentation] Analysis of GCH1 mutations in the patients with Parkinson’s disease in Japanese population2016
    • Author(s)
      Hiroyo Yoshino, Kenya Nishioka, Aya Ikeda, Takashi Matsushima, Mitsuaki Oki, Daigo Miyazaki, Yoshiki Sekijima, Ai Hosaka, Takekazu Ohi, Hiroshi Iwanaga, Yuanzhe Li, Manabu Funayama, Nobutaka Hattori
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2016-05-18
    • Data Source
      KAKENHI-PROJECT-25860726

  • [Presentation] In vivo evidence for the involvement of phospho-ubiquitin signal2016
    • Author(s)
      Shiba-Fukushima K, Ishikawa K-I, Takanashi M, Akamatsu W, Imai Y, Hattori N
    • Organizer
      第39回日本神経学会学術大会
    • Place of Presentation
      横浜市
    • Data Source
      KAKENHI-PROJECT-26293070

  • [Presentation] Loss of Parkinson’s disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c.2016
    • Author(s)
      Meng H, Yamashita C, Shiba-Fukushima K, Inoshita T, Funayama M, Sato S, Imai Y, Hattori N
    • Organizer
      第39回日本分子生物学会年会　シンポジウム
    • Place of Presentation
      横浜市
    • Data Source
      KAKENHI-PROJECT-26293070

  • [Presentation] The Loss of Parkinson's Disease-Associated Protein CHCHD2 Affects Mitochondrial Cristae Structure and Destabilizes Cytochrome c, Symposium 2PS9-42016
    • Author(s)
      Meng H, Yamashita C, Shiba K, Inoshita T, Funayama M, Sato S, Imai Y, Hattori N.
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-15H04842

  • [Presentation] Parkinson's disease-associated mutations of PLA2G6 alters the membrane dynamics.2016
    • Author(s)
      Mori A, Imai Y, Hattori N
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸コンベンションホール他、神戸
    • Year and Date
      2016-05-18
    • Data Source
      KAKENHI-PROJECT-15H04842

  • [Presentation] .The function of CHCHD2, the novel gene responsible for a familial form of Parkinson's disease, Symposium S1-D-3, Pathogenetic mechanisms underlying Parkinson's disease -On the roles of alpha-synuclein, mitochondria and lysosomes2016
    • Author(s)
      Hattori N, Funayama M, Imai Y, Sato S
    • Organizer
      The 39th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Pacifico Yokohama, Yokohama
    • Year and Date
      2016-07-20
    • Data Source
      KAKENHI-PROJECT-15H04842

  • [Presentation] パーキンソン病新規原因遺伝子CHCHD2の機能解析2016
    • Author(s)
      山下 力、孟紅蕊、井下強、福嶋佳保里、荒野拓、佐藤栄人、今居譲、服部信孝.
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸コンベンションホール他、神戸
    • Year and Date
      2016-05-18
    • Data Source
      KAKENHI-PROJECT-15H04842

  • [Presentation] 教育講演ベーシック明日からの臨床に役立つパーキンソン病診断　up to date2015
    • Author(s)
      西岡健弥　服部信孝
    • Organizer
      第５６回　日本神経学会総会
    • Place of Presentation
      新潟
    • Year and Date
      2015-05-20
    • Data Source
      KAKENHI-PROJECT-25860726

  • [Presentation] アルツハイマー病理をもつ皮質基底核症候群と診断された２症例の脳血流分布と神経病理2015
    • Author(s)
      林田有紗， 中山茶千子， 高梨雅史， 本井ゆみ子， 服部信孝
    • Organizer
      第56回日本神経学会学術大会
    • Place of Presentation
      新潟コンベンションセンター
    • Year and Date
      2015-05-20
    • Data Source
      KAKENHI-PROJECT-26460921

  • [Presentation] サル視床下核及び淡蒼球刺激における線条体介在ニューロンの反応2015
    • Author(s)
      下　泰司、中島明日香、宇賀貴紀、服部信孝
    • Organizer
      第５５回日本神経学会学術大会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-24591304

  • [Presentation] 脳内環境における封入体形成のメカニズム：封入体と神経細胞死の関連性について（演題名：新規遺伝性パーキンソン病からの解析から）（口演）2015
    • Author(s)
      服部信孝
    • Organizer
      文科省科研費補助金「新学術領域研究」　脳内環境：恒常性維持機構とその破綻、、平成27年度夏のワークショップ
    • Place of Presentation
      軽井沢プリンスホテルウエスト、軽井沢
    • Year and Date
      2015-09-25
    • Data Source
      KAKENHI-PLANNED-23111003

  • [Presentation] The effect of electrical stimulation of the subthalamic nucleus or internal part of the globus pallidus to primate striatal neuron2015
    • Author(s)
      Asuka Nakajima, Yasushi Shimo, Takanori Uka, Nobutaka Hattori
    • Organizer
      18th International congress of Parkinson's disease and Movement disorders
    • Place of Presentation
      スウェーデン
    • Data Source
      KAKENHI-PROJECT-24591304

  • [Presentation] Parkinson's disease-associated mutations of PLA2G6 alters the membrane dynamics、英語 ポスター2015
    • Author(s)
      森 聡生、王子 悠、奥住 文美、波田野 琢、今居 譲、久保 紳一郎、服部 信孝．
    • Organizer
      第56回日本神経学会総会
    • Place of Presentation
      朱鷺メッセ、新潟市
    • Year and Date
      2015-05-20
    • Data Source
      KAKENHI-PROJECT-15H04842

  • [Presentation] パーキンソン病の病態：遺伝性パーキンソン病の原因遺伝子からのアプローチ（ワークショップ）2015
    • Author(s)
      服部信孝
    • Organizer
      BMB2015（第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会）
    • Place of Presentation
      神戸ポートピアホテル、神戸市
    • Year and Date
      2015-12-03
    • Data Source
      KAKENHI-PLANNED-23111003

  • [Presentation] Mutations of a mitochondrial protein CHCHD2 in Drosophila lead to Parkinson’s disease-like phenotypes.2015
    • Author(s)
      Meng H, Yamashita C, Shiba-Fukushima K, Hattori N, Imai Y.
    • Organizer
      Cell Symposia, Multifaceted Mitochondria,
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2015-07-19
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04842

  • [Presentation] CHCHD2は家族性パーキンソン病の新規原因遺伝子である2015
    • Author(s)
      舩山 学、服部 信孝
    • Organizer
      第9回パーキンソン病・運動障害疾患コングレス
    • Place of Presentation
      品川プリンスホテル、東京
    • Year and Date
      2015-10-15
    • Data Source
      KAKENHI-PROJECT-15H04842

  • [Presentation] Hot Topic: Neuropathology of PINK1 homozygous mutation: Lewy-independent nigral degeneration resembling parkin mutatioｎ,2015
    • Author(s)
      Takanashi M, Hattori N.
    • Organizer
      10th Annual Genetic Epidemiology of Parkinson's Disease Consortium (GEO-PD）
    • Place of Presentation
      Roppongi Academyhills 49, Tokyo
    • Year and Date
      2015-10-02
    • Data Source
      KAKENHI-PLANNED-23111003

  • [Presentation] オートファジー欠損マウスにおける封入体形成機構の解明2015
    • Author(s)
      佐藤栄人、服部信孝．
    • Organizer
      文科省科研費補助金「新学術領域研究」　脳内環境：恒常性維持機構とその破綻、平成27年度夏のワークショップ
    • Place of Presentation
      軽井沢プリンスホテルウエスト、軽井沢
    • Year and Date
      2015-09-25
    • Data Source
      KAKENHI-PROJECT-15H04842

  • [Presentation] ドパミントランスポーターシンチグラフィを用いた原発性進行性失語症の臨床解析2015
    • Author(s)
      中村亮太， 中山茶千子， 本井ゆみ子， 服部信孝
    • Organizer
      第56回日本神経学会学術大会
    • Place of Presentation
      新潟コンベンションセンター
    • Year and Date
      2015-05-20
    • Data Source
      KAKENHI-PROJECT-26460921

  • [Presentation] Clinicogenetic study of CHCHD2 in patients with autosomal dominant familial Parkinson's disease, Poster, XXII World Congress of Neurology, Casa Piedra, Centro de Eventos, Congresos y Exhibiciones2015
    • Author(s)
      Hattori N, Funayama M.
    • Organizer
      XXII World Congress of Neurology, World Congress of Neurology 2015
    • Place of Presentation
      Santiago, Chili
    • Year and Date
      2015-11-01
    • Data Source
      KAKENHI-PLANNED-23111003

  • [Presentation] ドパミントランスポーターシンチグラフィを用いた原発性進行性失語症の臨床解析2015
    • Author(s)
      中村亮太， 中山茶千子， 本井ゆみ子， 服部信孝
    • Organizer
      日本神経学会総会
    • Place of Presentation
      新潟市朱鷺メッセ
    • Year and Date
      2015-05-23
    • Data Source
      KAKENHI-PROJECT-26460921

  • [Presentation] Regulation of mitochondrial division and mitophagy by syntaxin 17. Cell Symposia, Multifaceted Mitochondria2015
    • Author(s)
      Arasaki K, Sugo M, Hirota N, Dohmae N, Ortiz-Sandoval C, Simmen T, Imai Y, Hattori N, Tagaya M
    • Organizer
      Cell Symposia
    • Place of Presentation
      シカゴ
    • Year and Date
      2015-07-19
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293070

  • [Presentation] パーキンソン病に対するDBS適応判定におけるEARLYSTIMULUSの有用性2015
    • Author(s)
      梅村淳，中島円，大山彦光，下泰司，中島明日香，城崇之，関本智子，伊藤賢伸，服部信孝，新井一
    • Organizer
      社団法人日本脳神経外科学会　第74回学術総会
    • Place of Presentation
      札幌
    • Year and Date
      2015-10-14
    • Data Source
      KAKENHI-PROJECT-26462219

  • [Presentation] CHCHD2 is novel gene for autosomal dominant Parkinson's disease, -Neurodegenerative disorders in cells to animals-　Symposium"At the Bench"2015
    • Author(s)
      Funayama M, Hattori N.
    • Organizer
      10th Annual Genetic Epidemiology of Parkinson's Disease Consortium (GEO-PD)
    • Place of Presentation
      Roppongi Academyhills 49, Tokyo
    • Year and Date
      2015-10-02
    • Data Source
      KAKENHI-PLANNED-23111003

  • [Presentation] Pathological perspective on autophagy lysosome pathway in Parkinson's disease, -Neurodegenerative disorders in cells to animals- Symposium "At the Bench"2015
    • Author(s)
      Sato S, Hattori N.
    • Organizer
      10th Annual Genetic Epidemiology of Parkinson's Disease Consortium (GEO-PD)
    • Place of Presentation
      Roppongi Academyhills 49, Tokyo
    • Year and Date
      2015-10-02
    • Data Source
      KAKENHI-PLANNED-23111003

  • [Presentation] CHCHD2は家族性パーキンソン病の新規原因遺伝子である2015
    • Author(s)
      舩山 学、服部 信孝
    • Organizer
      第9回パーキンソン病・運動障害疾患コングレス
    • Place of Presentation
      品川プリンスホテル、東京
    • Year and Date
      2015-10-15
    • Data Source
      KAKENHI-PLANNED-23111003

  • [Presentation] Regulation of mitochondrial division and mitophagy by syntaxin 17.2015
    • Author(s)
      Arasaki K, Sugo M, Hirota N, Dohmae N, Ortiz-Sandoval C, Simmen T, Imai Y, Hattori N, Tagaya M
    • Organizer
      Cell Symposia, Multifaceted Mitochondria
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2015-07-19
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04842

  • [Presentation] 運動障害の目立たないPossible DLBのドパミントランスポーターシンチを用いた臨床解 析2015
    • Author(s)
      林徹生， 中山茶千子， 本井ゆみ子， 服部信孝
    • Organizer
      日本神経学会総会
    • Place of Presentation
      新潟市朱鷺メッセ
    • Year and Date
      2015-05-20
    • Data Source
      KAKENHI-PROJECT-26460921

  • [Presentation] PINK1-Parkinシグナルによるミトコンドリアの品質管理機構、ワークショップ　フォスタグ技術による神経科学へのアプローチ　- タンパク質リン酸化研究の新潮流 -2015
    • Author(s)
      柴　佳保里、今居　譲、服部信孝
    • Organizer
      第38回日本分子生物学会年会（BMB2015）
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-15H04842

  • [Presentation] Circadian rhythm analysis in a Drosophila model of Parkinson's syndrome、ポスター(英語)2015
    • Author(s)
      穂坂 有加、今居 譲、服部 信孝
    • Organizer
      第56回日本神経学会総会
    • Place of Presentation
      朱鷺メッセ、新潟市
    • Year and Date
      2015-05-20
    • Data Source
      KAKENHI-PROJECT-15H04842

  • [Presentation] サル視床下核及び淡蒼球刺激における線条体介在ニューロンの反応2015
    • Author(s)
      下　泰司　中島明日香　宇賀貴紀　服部信孝
    • Organizer
      第55回日本神経学会学術集会
    • Place of Presentation
      福岡国際会議場（福岡）
    • Year and Date
      2015-05-23
    • Data Source
      KAKENHI-PROJECT-24591304

  • [Presentation] パーキンソン病の変性部位におけるアストロサイトの検討、［PD2-21]ポスター2015
    • Author(s)
      高梨 雅史、服部 信孝
    • Organizer
      第33回日本神経治療学会
    • Place of Presentation
      名古屋国際会議場・イベントホール、名古屋
    • Year and Date
      2015-11-27
    • Data Source
      KAKENHI-PLANNED-23111003

  • [Presentation] Phosphorylation of Mitochondrial Polyubiquitin by PINK1 Promotes Parkin Mitochondrial Tethering2015
    • Author(s)
      Shiba-Fukushima K, Arano T, Matsumoto G, Inoshita T, Yoshida S, Ishihama Y, Ryu K-K, Nukina N, Imai Y, Hattori N
    • Organizer
      第56回日本神経学会学術大会
    • Place of Presentation
      朱鷺メッセ（新潟県新潟市）
    • Year and Date
      2015-05-23
    • Data Source
      KAKENHI-PROJECT-26293070

  • [Presentation] オートファジー欠損マウスにおける封入体形成機構の解明（ポスター）2015
    • Author(s)
      佐藤栄人、服部信孝．
    • Organizer
      文科省科研費補助金「新学術領域研究」　脳内環境：恒常性維持機構とその破綻、平成27年度夏のワークショップ
    • Place of Presentation
      軽井沢プリンスホテルウエスト、軽井沢
    • Year and Date
      2015-09-25
    • Data Source
      KAKENHI-PLANNED-23111003

  • [Presentation] Parkinson's disease-associated proteins Vps35 and LRRK2 regulate synaptic vesicle dynamics, Oral Session2015
    • Author(s)
      Inoshita T, Hosaka Y, Imai Y, Hattori N.
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸コンベンションセンター
    • Year and Date
      2015-07-28
    • Data Source
      KAKENHI-PROJECT-15H04842

  • [Presentation] ミトコンドリア呼吸鎖遺伝子改変マウスにおけるMPTP感受性の検討（ポスター）2015
    • Author(s)
      舩山 学、服部 信孝
    • Organizer
      第9回パーキンソン病・運動障害疾患コングレス
    • Place of Presentation
      品川プリンスホテル、東京
    • Year and Date
      2015-10-15
    • Data Source
      KAKENHI-PROJECT-15H04842

  • [Presentation] Usefulness of interleaving programing in pallidal stimulation for Parkinson’s disease.2015
    • Author(s)
      Umemura A, Oyama G, Shimo Y, Nakajima A, Jo T, Nakajima M, Ishii H, Arai H, Hattori N
    • Organizer
      1st International Brain Stimulation Conference
    • Place of Presentation
      Singapore
    • Year and Date
      2015-04-02
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26462219

  • [Presentation] Mutations of a mitochondrial protein CHCHD2 in Drosophila lead to Parkinson’s disease-like phenotypes2015
    • Author(s)
      Meng H, Yamashita C, Shiba-Fukushima K, Hattori N, Imai Y
    • Organizer
      Cell Symposia
    • Place of Presentation
      シカゴ
    • Year and Date
      2015-07-19
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293070

  • [Presentation] 淡蒼球内節脳深部刺激療法のinterleaving stimulation 法2014
    • Author(s)
      下　泰司　大山彦光、中島明日香、西川奈津子、中島円、石井尚登、梅村淳、服部信孝
    • Organizer
      第５３回日本定位機能神経外科学会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-24591304

  • [Presentation] オートファジー調節作用を持つ薬剤の探索 -既存薬ライブラリーを用いて-2014
    • Author(s)
      平野一興、斉木臣二、古屋徳彦、山田大介、石川景一、佐谷秀行、服部信孝
    • Organizer
      厚生労働科学研究委託事業　難治性疾患等克服研究事業　「パーキンソン病患者由来iPS細胞を中心とする多面的疾患モデルに立脚した革新的医薬品の開発」　第2回班会議
    • Place of Presentation
      順天堂大学10号館1階会議室、東京
    • Year and Date
      2014-12-18
    • Data Source
      KAKENHI-PLANNED-25111007

  • [Presentation] PINK1-Parkinミトコンドリア品質管理機構に関与する分子の探索2014
    • Author(s)
      柴 佳保里、井下　強、梅崎 勇次郎、今居　譲、服部 信孝
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      福岡
    • Year and Date
      2014-05-23
    • Data Source
      KAKENHI-PROJECT-26461280

  • [Presentation] PINK1-Parkinミトコンドリア品質管理機構に関与する分子の探索2014
    • Author(s)
      柴 佳保里、井下　強、梅崎 勇次郎、今居　譲、服部 信孝
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      福岡国際会議場（福岡県・福岡市）
    • Year and Date
      2014-05-23
    • Data Source
      KAKENHI-PROJECT-26293070

  • [Presentation] The effect of electrical stimulation of the subthalamic nucleus (STN) or internal part of the globus pallidus (GPi) to primate striatal interneurons2014
    • Author(s)
      Shimo Y, Nakajima A. UkaT, Hattori N
    • Organizer
      4th Asian and Oceanian Parkinson's disease and Movement disorders Congress
    • Place of Presentation
      パタヤ（フィリピン）
    • Year and Date
      2014-11-30
    • Data Source
      KAKENHI-PROJECT-24591304

  • [Presentation] ペリー症候群の分子病態とアポトーシスの関係2014
    • Author(s)
      石川景一, 斉木臣二, 古屋徳彦, 山田大介, 今道洋子, 李元哲, 河尻澄宏, 佐々木寛典, 小池正人, 坪井義夫，服部信孝
    • Organizer
      カテコールアミンと神経疾患研究会 2014
    • Place of Presentation
      品川プリンスホテル
    • Year and Date
      2014-04-19
    • Data Source
      KAKENHI-PLANNED-25111007

  • [Presentation] Lysine 63-linked polyubiquitination is dispensable for Parkin-mediated mitophagy2014
    • Author(s)
      Shiba-Fukushima K, Inoshita T, Hattori N, Imai Y
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-11
    • Data Source
      KAKENHI-PROJECT-26461280

  • [Presentation] 精神発達遅滞と片側パーキンソニズムを呈しWDR45遺伝子変異を認めたNBIAの36歳女性例2014
    • Author(s)
      中里朋子、大山彦光、西岡健弥、吉野浩代、服部信孝
    • Organizer
      日本神経学会関東地方会
    • Place of Presentation
      砂防会館
    • Year and Date
      2014-05-31
    • Data Source
      KAKENHI-PROJECT-25860726

  • [Presentation] The effect of electrical stimulation of the subthalamic nucleus (STN) or internal part of the globus pallidus (GPi) to primate striatal neurons.2014
    • Author(s)
      Shimo Y, Nakajima A. UkaT, Hattori N
    • Organizer
      北米神経科学会
    • Place of Presentation
      Wasington USA
    • Year and Date
      2014-11-17
    • Data Source
      KAKENHI-PROJECT-24591304

  • [Presentation] Lysine 63-linked polyubiquitination is dispensable for Parkin-mediated mitophagy2014
    • Author(s)
      Shiba-Fukushima K, Inoshita T, Hattori N, Imai Y
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜（神奈川県・横浜）
    • Year and Date
      2014-09-11
    • Data Source
      KAKENHI-PROJECT-26293070

  • [Presentation] 日本人パーキンソン病における網羅的遺伝子解析2013
    • Author(s)
      吉野浩代、富山弘幸、今道洋子、李　元哲、大垣光太郎、安藤真矢、舩山　学、服部信孝
    • Organizer
      第54回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム、東京
    • Data Source
      KAKENHI-PROJECT-24390224

  • [Presentation] 若年性パーキンソン病原因遺伝子産物ATP13A2の機能解析2013
    • Author(s)
      佐藤栄人、里　史明、松井秀彰、小池正人、金井数明、斉木臣二、舩山　学、武田俊一、内山安男、高橋良輔、服部信孝
    • Organizer
      第54回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム、東京
    • Data Source
      KAKENHI-PROJECT-24390224

  • [Presentation] A Screening of Neuroprotective Compounds for Parkinson's Disease from Herbal Medicines2013
    • Author(s)
      Yamada D, Fujimaki T, Saiki S, Tashiro E, Funayama M, Imoto Masaya, Hattori N.
    • Organizer
      International Symposium on Mitochondoria 2013, The 13th Conference of Japaneses Society of Mitochondrial Research and Medicine(J-mit)
    • Place of Presentation
      六本木ヒルズ　アカデミーヒルズ、東京
    • Data Source
      KAKENHI-PROJECT-24390224

  • [Presentation] Parkinノックアウトマウスにおける放出機構の検討2013
    • Author(s)
      江口博人、今泉美佳、塚口ケネス、福嶋佳保里、佐藤栄人、舩山　学、斉木臣二、波田野琢、久保紳一郎、今居譲、永松信哉、服部信孝
    • Organizer
      第54回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム、東京
    • Data Source
      KAKENHI-PROJECT-24390224

  • [Presentation] PINK1/parkin過剰発現によるmictophagyとapoptosis誘導作用について2013
    • Author(s)
      江口博人、今泉美佳、塚口ケネス、福嶋佳保里、佐藤栄人、舩山　学、斉木臣二、波田野琢、久保紳一郎、今居譲、永松信哉、服部信孝
    • Organizer
      第54回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム、東京
    • Data Source
      KAKENHI-PLANNED-23111003

  • [Presentation] PLA2G6における細胞内局在の検討2013
    • Author(s)
      森　聡生、王子　悠、波田野琢、久保紳一郎、服部信孝
    • Organizer
      第54回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム、東京
    • Data Source
      KAKENHI-PLANNED-23111003

  • [Presentation] PLA2G6における細胞内局在の検討2013
    • Author(s)
      森　聡生、王子　悠、波田野琢、久保紳一郎、服部信孝
    • Organizer
      第54回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム、東京
    • Data Source
      KAKENHI-PROJECT-24390224

  • [Presentation] 日本人パーキンソン病におけるVPS35 D620N変異の同定2013
    • Author(s)
      舩山　学、安藤真矢、李　元哲、柏原健一、村上善勇、石津暢隆、豊田千純子、野口克彦、橋本貴司、中野直樹、佐々木良元、小久保康昌、葛原茂樹、大垣光太郎、山下　力、吉野浩代、波田野琢、富山弘幸、服部信孝
    • Organizer
      第54回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム、東京
    • Data Source
      KAKENHI-PROJECT-24390224

  • [Presentation] 視床下核電気刺激によるサル線条体ドパミン放出増加とTAN発火抑制2013
    • Author(s)
      中島明日香、下　泰司、吉見健二、大山彦光、宇賀貴紀、服部信孝
    • Organizer
      日本神経学会学術大会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24591304

  • [Presentation] Levodopa-responsive Parkinsonism following bilateral putaminal hemorrhages2013
    • Author(s)
      Hatano T, Kubo SI, Niijima-Ishii Y, Sugita H, Hattori N.
    • Organizer
      MDS 17th International Congress
    • Place of Presentation
      Sydney, Australia
    • Data Source
      KAKENHI-PROJECT-24390224

  • [Presentation] GBA変異によるグルコシルセラミダーゼの局在の検討2013
    • Author(s)
      王子　悠、森　聡生、波田野琢、久保紳一郎、服部信孝
    • Organizer
      第54回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム、東京
    • Data Source
      KAKENHI-PLANNED-23111003

  • [Presentation] GBA変異によるグルコシルセラミダーゼの局在の検討2013
    • Author(s)
      王子　悠、森　聡生、波田野琢、久保紳一郎、服部信孝
    • Organizer
      第54回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム、東京
    • Data Source
      KAKENHI-PROJECT-24390224

  • [Presentation] ペリー症候群の原因遺伝子産物ダイナクチンの機能解析2013
    • Author(s)
      石川景一、斉木臣二、今道洋子、佐藤栄人、河尻澄宏、李　元哲、服部信孝
    • Organizer
      第54回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム、東京
    • Data Source
      KAKENHI-PROJECT-24390224

  • [Presentation] Presidential Lecture, Impaired mitochondorial dysnamics and function in the pathogenesis of Parkinson's disease2013
    • Author(s)
      Hattori N.
    • Organizer
      International Symposium on Mitochondoria 2013, The 13th Conference of Japaneses Society of Mitochondrial Research and Medicine(J-mit)
    • Place of Presentation
      六本木ヒルズ　アカデミーヒルズ、東京
    • Data Source
      KAKENHI-PROJECT-24390224

  • [Presentation] Presidential Lecture, Impaired mitochondorial dysnamics and function in the pathogenesis of Parkinson's disease2013
    • Author(s)
      Hattori N.
    • Organizer
      International Symposium on Mitochondoria 2013, The 13th Conference of Japaneses Society of Mitochondrial Research and Medicine(J-mit)
    • Place of Presentation
      六本木ヒルズ　アカデミーヒルズ、東京
    • Data Source
      KAKENHI-PLANNED-23111003

  • [Presentation] ペリー症候群の原因遺伝子産物ダイナクチンの機能解析2013
    • Author(s)
      福嶋佳保里、今居　譲、吉田繁治、石濱　泰、金尾智子、佐藤栄人、服部信孝
    • Organizer
      第54回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム、東京
    • Data Source
      KAKENHI-PLANNED-23111003

  • [Presentation] Familial Parkinsonism(FPD) : Its Pathogenesis Provides a Hint for Elucidating the Pathogenesis for Nigral Neurodegeneration2012
    • Author(s)
      Nobutaka Hattori, MD,PhD
    • Organizer
      Mackey International Symposium : Mitoc hondrial Dysfunction and Aging-related Disease
    • Place of Presentation
      New Taipei City, Taiwan
    • Year and Date
      2012-07-08
    • Data Source
      KAKENHI-PROJECT-24390224

  • [Presentation] Familial Parkinsonism(FPD): Its Pathogenesis Provides a Hint for Elucidating the Pathogenesis for Nigral Neurodegeneration2012
    • Author(s)
      Nobutaka Hattori, MD,PhD
    • Organizer
      2012 Mackey International Symposium: Mitochondrial Dysfunction and Aging-related Disease
    • Place of Presentation
      New Taipei City, Taiwan
    • Invited
    • Data Source
      KAKENHI-PLANNED-23111003

  • [Presentation] Clinicogenetic study of patients with FTDP-17(MAPT) in Japan2011
    • Author(s)
      K. Ogaki, Y. Li, M. Takanashi, K. Ishikawa, T. Kobayashi, A. Nakanishi, T. Nonaka, M. Hasegawa, M. Kishi, H. Yoshino, M. Funayama, K. Shioya, M. Yokochi, R. Sasaki, Y. Kokubo, S. Kuzuhara, Y. Motoi, H. Tomiyama, N. Hattori
    • Organizer
      The 12th International Congress of Human Genetics, ICHG and the American Society of Human Genetics, ASHG 61st Annual Meeting
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2011-10-14
    • Data Source
      KAKENHI-PROJECT-21591098

  • [Presentation] パーキンソン病2011
    • Author(s)
      服部信孝
    • Organizer
      第38回ヒューマンサイエンス総合研究セミナー「難病創薬のビジネスモデルと可能性-神経変性疾患を中心-」に係る講師の依頼について,平成23年度厚生労働科学研究費補助金政策創薬総合研究事業,立がん研究センター内
    • Place of Presentation
      国際研究交流会館(東京)
    • Year and Date
      2011-10-03
    • Data Source
      KAKENHI-PROJECT-21390272

  • [Presentation] 加齢と神経変性疾2011
    • Author(s)
      服部信孝
    • Organizer
      第11回日本抗加齢医学会総会,日国立京都国会館
    • Place of Presentation
      日国立京都国会館
    • Year and Date
      2011-05-27
    • Data Source
      KAKENHI-PROJECT-21390272

  • [Presentation] Neurodegeneration-Prevention-Regeneration2011
    • Author(s)
      服部信孝
    • Organizer
      Preventive and Translational Medicine-Perspectives for 21 Centuries. Joint Japanese-German Symposium
    • Place of Presentation
      Juntendo University
    • Year and Date
      2011-09-27
    • Data Source
      KAKENHI-PROJECT-21390272

  • [Presentation] パーキンソン病の病態と治療2011
    • Author(s)
      服部信孝
    • Organizer
      兵庫・岡山神経内科合同カンファレンスin Kobe
    • Place of Presentation
      ホテルサンルートソプラ神戸
    • Year and Date
      2011-05-07
    • Data Source
      KAKENHI-PUBLICLY-23110518

  • [Presentation] 加齢と神経変性疾,ベーシックサイエンス企画シンポジウム2,「加齢性疾患とエピジェネティクス」2011
    • Author(s)
      服部信孝
    • Organizer
      第11回日本抗加齢医学会総会
    • Place of Presentation
      日国立京都国会館
    • Year and Date
      2011-05-27
    • Data Source
      KAKENHI-PROJECT-21390272

  • [Presentation] 神経変性をどう考えるか?病態理解に至る最近の進歩2011
    • Author(s)
      服部信孝
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-05-19
    • Data Source
      KAKENHI-PROJECT-21390272

  • [Presentation] Analyses of compound heterozygous rearrangements of parkin2011
    • Author(s)
      M. Funayama, H. Kusaka, H. Yoshino, Y. Li, K. Ogaki, H. Tomiyama, N. Hattori
    • Organizer
      The 12th International Congress of Human Genetics, ICHG and the American Society of Human Genetics, ASHG 61st Annual Meeting
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2011-10-14
    • Data Source
      KAKENHI-PROJECT-21591098

  • [Presentation] パーキンソン病の診断と治療2011
    • Author(s)
      服部信孝
    • Organizer
      健康セミナー-パーキンソン病とともに生活する-
    • Place of Presentation
      東京国立近代美術館
    • Year and Date
      2011-04-05
    • Data Source
      KAKENHI-PUBLICLY-23110518

  • [Presentation] Mitophagy and Parkinson Disease2011
    • Author(s)
      服部信孝
    • Organizer
      東京医科歯科大学歯学部特別講堂
    • Place of Presentation
      東京医科歯科大学
    • Year and Date
      2011-06-11
    • Data Source
      KAKENHI-PUBLICLY-23110518

  • [Presentation] 神経変性をどう考えるか?病態理解に至る最近の進歩.シンポジウム14「若年性パーキンソン病の病態解明:インスリン開口機構からその病因に迫る」2011
    • Author(s)
      服部信孝
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-05-19
    • Data Source
      KAKENHI-PROJECT-21390272

  • [Presentation] Analysis of the FBXO7 gene in early-onset parkinsonism2011
    • Author(s)
      Y. Li, M. Funayama, H. Yoshino, H. Tomiyama, N. Hattori
    • Organizer
      The 12th International Congress of Human Genetics, ICHG and the American Society of Human Genetics, ASHG 61st Annual Meeting
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2011-10-14
    • Data Source
      KAKENHI-PROJECT-21591098

  • [Presentation] Parkinson病治療ガイドラインの国際比較2011
    • Author(s)
      服部信孝
    • Organizer
      神経疾患治療ガイドライン国際比較からみた本邦の特徴
    • Place of Presentation
      東京
    • Year and Date
      2011-11-18
    • Data Source
      KAKENHI-PLANNED-23111003

  • [Presentation] Parkinson病治療ガイドラインの国際比較2011
    • Author(s)
      服部信孝
    • Organizer
      神経疾患治療ガイドライン国際比較からみた本邦の特徴
    • Place of Presentation
      東京
    • Year and Date
      2011-11-18
    • Data Source
      KAKENHI-PROJECT-21390272

  • [Presentation] パーキンソン病の分子病態機序2011
    • Author(s)
      服部信孝
    • Organizer
      第28回日本医学会総会2011
    • Place of Presentation
      東京
    • Year and Date
      2011-04-09
    • Data Source
      KAKENHI-PROJECT-21390272

  • [Presentation] 日本人パーキンソニズムにおけるDCTN1変異解析-Perry症候群について2011
    • Author(s)
      富山弘幸, 李林, 中尾紘一, 京楽格, 栗崎玲一, 李元哲, 舩山学, 吉野浩代, 音成龍司, 坪井義夫, 服部信孝
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-05-18
    • Data Source
      KAKENHI-PROJECT-21591098

  • [Presentation] Neurodegeneration. Prevention-Regeneration. Academic Session : Preventive and Translational Medicine. Perspectives for 21 Centuries2011
    • Author(s)
      服部信孝
    • Organizer
      Joint Japanese. German Symposium
    • Place of Presentation
      Juntendo University
    • Year and Date
      2011-09-27
    • Data Source
      KAKENHI-PROJECT-21390272

  • [Presentation] 加齢と神経変性疾2011
    • Author(s)
      服部信孝
    • Organizer
      第11回日本抗加齢医学会総会,日国立京都国会館
    • Place of Presentation
      日国立京都国会館
    • Year and Date
      2011-05-27
    • Data Source
      KAKENHI-PLANNED-23111003

  • [Presentation] パーキンソン病の嚥下に関する臨床的検討2011
    • Author(s)
      羽鳥浩三、鈴木康司、石橋郁子、林康子、寺門厚彦、服部信孝、赤居正美、長岡正範
    • Organizer
      第48回日本リハビリテーション医学会学術集会
    • Place of Presentation
      千葉(幕張メッセ)
    • Year and Date
      2011-11-02
    • Data Source
      KAKENHI-PROJECT-22500478

  • [Presentation] 神経変性をどう考えるか?病態理解に至る最近の進歩2011
    • Author(s)
      服部信孝
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-05-19
    • Data Source
      KAKENHI-PLANNED-23111003

  • [Presentation] Mitophagy and Parkinson Disease2011
    • Author(s)
      服部信孝
    • Organizer
      東京医科歯科大学歯学部特別講堂
    • Place of Presentation
      東京医科歯科大学
    • Year and Date
      2011-06-11
    • Data Source
      KAKENHI-PLANNED-23111003

  • [Presentation] PLA2G6 in patients with Parkinson's disease/frontotemporal type of dementia2011
    • Author(s)
      H. Tomiyama, H. Yoshino, K. Ogaki, L. Li, C. Yamashita, Y. Li, M. Funayama, R. Sasaki, Y. Kokubo, S. Kuzuhara, and N. Hattori
    • Organizer
      The 12th International Congress of Human Genetics, ICHG and the American Society of Human Genetics, ASHG 61st Annual Meeting
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2011-10-14
    • Data Source
      KAKENHI-PROJECT-21591098

  • [Presentation] 日本人パーキンソニズム症例におけるDCTN1解析2011
    • Author(s)
      富山弘幸, 李林, 中尾紘一, 京楽格, 栗崎玲一, 李元哲, 舩山学, 吉野浩代, 音成龍司, 坪井義夫, 服部信孝
    • Organizer
      日本人類遺伝学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-12
    • Data Source
      KAKENHI-PROJECT-21591098

  • [Presentation] パーキンソン病の分子病態機序2011
    • Author(s)
      服部信孝
    • Organizer
      第28回日本医学会総会2011
    • Place of Presentation
      東京
    • Year and Date
      2011-04-09
    • Data Source
      KAKENHI-PLANNED-23111003

  • [Presentation] パーキンソニズムにおけるDCTN1解析-Perry症候群とパーキンソン病の異同について2011
    • Author(s)
      富山弘幸, 李林, 中尾紘一, 京楽格, 栗崎玲一, 李元哲, 舩山学, 吉野浩代, 音成龍司, 坪井義夫, 服部信孝
    • Organizer
      第5回パーキンソン病・運動障害疾患コングレス
    • Place of Presentation
      東京
    • Year and Date
      2011-10-08
    • Data Source
      KAKENHI-PROJECT-21591098

  • [Presentation] Mitophagy and Parkinson Disease2011
    • Author(s)
      服部信孝
    • Organizer
      東京医科歯科大学歯学部特別講堂
    • Place of Presentation
      東京医科歯科大学
    • Year and Date
      2011-06-11
    • Data Source
      KAKENHI-PROJECT-21390272

  • [Presentation] 加齢と神経変性疾患2011
    • Author(s)
      服部信孝
    • Organizer
      第11回日本抗加齢医学会総会
    • Place of Presentation
      国立京都国会館
    • Year and Date
      2011-05-27
    • Data Source
      KAKENHI-PUBLICLY-23110518

  • [Presentation] Japanese subsequent GWAS identifies strong association at a novel risk locus and MCCC1 for Parkinson's disease2011
    • Author(s)
      W. Satake, K. Yamamoto, Y. Nakabayashi, M. Kubo, T. Morizono, T. Kawaguchi, T. Tsunoda, H. Tomiyama, M. Yamamoto, N. Hattori, M. Murata, Y. Nakamura, T. Toda
    • Organizer
      The 12th International Congress of Human Genetics, ICHG and the American Society of Human Genetics, ASHG 61st Annual Meeting
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2011-10-14
    • Data Source
      KAKENHI-PROJECT-21591098

  • [Presentation] 遺伝性パーキンソン病の共通分子基盤の解明2011
    • Author(s)
      服部信孝
    • Organizer
      仙台神経変性疾患検討会
    • Place of Presentation
      仙台
    • Year and Date
      2011-12-08
    • Data Source
      KAKENHI-PLANNED-23111003

  • [Presentation] Neurodegeneration-Prevention-Regeneration2011
    • Author(s)
      服部信孝
    • Organizer
      Preventive and Translational Medicine-Perspectives for 21 Centuries. Joint Japanese-German Symposium
    • Place of Presentation
      Juntendo University
    • Year and Date
      2011-09-27
    • Data Source
      KAKENHI-PLANNED-23111003

  • [Presentation] 遺伝性パーキンソン病の共通分子基盤の解明2011