Shiba Kahori 柴佳保里

… Alternative Names

SHIBA Kahori 柴佳保里

福嶋佳保里

KAHORI Shiba 柴佳保里

Less

Researcher Number	30468582
Other IDs
Affiliation (Current)	2025: 順天堂大学, 大学院医学研究科, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2023: 順天堂大学, 大学院医学研究科, 准教授 2017 – 2020: 順天堂大学, 医学(系)研究科(研究院), 准教授 2017: 順天堂大学, 医学研究科, 准教授 2014 – 2016: 順天堂大学, 医学(系)研究科(研究院), 助教 2012 – 2013: 順天堂大学, 医学(系)研究科(研究院), 研究員 … More 2009: Juntendo University, 医学部, 博士研究員 2009: Juntendo University, 大学院・医学研究科, 博士研究員 2008: Juntendo University, 医学研究科, 博士研究員 Less
Review Section/Research Field	Principal Investigator Neurology / Basic Section 52020:Neurology-related Except Principal Investigator Pathological medical chemistry / Basic Section 49010:Pathological biochemistry-related / Neurology
Keywords	Principal Investigator Parkin / PINK1 / mitophagy / 遺伝性パーキンソン病 / パーキンソン病 / マイトファジー / Parkinson's disease / VPS13 / オートファジー / VPS13C … More / ANKFY1 / ミトコンドリア / 家族性パーキンソン病 / parkin … More Except Principal Investigator パーキンソン病 / ショウジョウバエ / ミトコンドリア / iPS / iPS細胞 / ドーパミン神経 / 創薬 / リン脂質 / 神経変性疾患 / シグナル伝達 / ドパミン神経 / CHCHD2 / Parkin / PINK1 / ELOVL7 / PLA2G6 / 脂質解析 / リソソーム / 脂質 / α-Synuclein / 酵素 / 脳神経疾患 / スクリーニング / カルシウム / 光遺伝学 / カルシウムチャネル / カルシウムイメージング / alpha-Synuclein / メンブレンダイナミクス / 創薬探索 / シナプス小胞 / 神経シナプス / αシヌクレイン / キナーゼ / 神経変性 / 遺伝学 / 酸化ストレス / ユビキチン / リン酸化 Less

PINK1-Parkin介在性マイトファジーの分子機構の解明Principal Investigator
- Principal Investigator
  
  柴佳保里
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Juntendo University
Autophagy Regulation Mechanism by Parkinson's Disease Causal Gene Product VPS13CPrincipal Investigator
- Principal Investigator
  
  Shiba Kahori
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Juntendo University
Elucidation of intracellular environmental factors that produce a risk for alpha-Synuclein seeding
- Principal Investigator
  
  Imai Yuzuru
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Juntendo University
Functional analysis of novel molecules involved in PINK1-Parkin-mediated mitophagyPrincipal Investigator
- Principal Investigator
  
  Shiba Kahori
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Juntendo University
Exploration of Parkinson disease-specific pathological background
- Principal Investigator
  
  IMAI Yuzuru
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Juntendo University
Drug screening to improve mitochondrial functions
- Principal Investigator
  
  Imai Yuzuru
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Juntendo University
A study on the common pathogenesis of Parkinson's disease as a mitochondrial disease
- Principal Investigator
  
  Imai Yuzuru
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Juntendo University
Elucidation of the mechanism of mitochondrial maintenance by Parkinson's disease gene productsPrincipal Investigator
- Principal Investigator
  
  SHIBA Kahori
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Juntendo University
Identification of molecular mechanism of mitochondrial quality control by PINK1-Parkin pathwayPrincipal Investigator
- Principal Investigator
  
  SHIBA Kahori
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Juntendo University
Analysis of PINK1 stabilization molecular mechanism by ParkinPrincipal Investigator
- Principal Investigator
  
  KAHORI Shiba
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Juntendo University

[Book] 順天堂大脳神経内科ではこうしている　最新パーキンソン病診療【電子版付】2021
- Author(s)
  服部信孝、柴-福嶋佳保里
- Total Pages
  224
- Publisher
  日本医事新報社
- ISBN
  9784784949502
- Data Source
  KAKENHI-PROJECT-20K07910
[Book] 認知症　発症前治療のために解明すべき分子病態は何か？ -劣性遺伝性若年性パーキンソン病(AR-JP)の臨床、病理、分子遺伝学2017
- Author(s)
  服部信孝、今居　譲、柴佳保里
- Total Pages
  252
- Publisher
  羊土社
- ISBN
  9784758103640
- Data Source
  KAKENHI-PROJECT-17H04049
[Book] 週刊　医学のあゆみ　ミトコンドリア研究 UPDATE2017
- Author(s)
  今居　譲、柴佳保里、服部信孝
- Total Pages
  127
- Publisher
  医歯薬出版
- ISBN
  4910204710178
- Data Source
  KAKENHI-PROJECT-17H04049
[Book] 別冊　医学のあゆみ　ミトコンドリア研究 UPDATE2017
- Author(s)
  今居　譲、柴佳保里、服部信孝
- Total Pages
  128
- Publisher
  医歯薬出版
- ISBN
  4910204761071
- Data Source
  KAKENHI-PROJECT-17H04049
[Book] 遺伝子から探るパーキンソン病病態へのミトコンドリアの関与2017
- Author(s)
  今居　譲、柴佳保里、服部信孝
- Total Pages
  127
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-PROJECT-16K15484
[Book] Methods Mol Biol.2017
- Author(s)
  Imai Y, Inoshita T, Shiba-Fukushima K, Meng H, Hattori N
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-26293070
[Book] 実験医学2015
- Author(s)
  今居　譲、柴佳保里、服部信孝
- Total Pages
  134
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-26461280
[Journal Article] Ubiquitination at the lysine 27 residue of the Parkin ubiquitin-like domain is suggestive of a new mechanism of Parkin activation.2022
- Author(s)
  Liu J-Y, Inoshita T, Shiba-Fukushima K, Yoshida K, Ishihama Y, Imai Y, Hattori N.
- Journal Title
  
  Hum Mol Genet.
  
  Volume: 31 Issue: 15 Pages: 2623-2638
- DOI
  10.1093/hmg/ddac064
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07910, KAKENHI-PROJECT-21H04820, KAKENHI-PROJECT-20H03453, KAKENHI-PROJECT-20K21531
[Journal Article] α-Synuclein V15A variant in familial Parkinson's disease exhibits a weaker lipid-binding property.2022
- Author(s)
  Daida K, Shimonaka S, Shiba-Fukushima K, Ogata J, Yoshino H, Okuzumi A, Hatano T, Motoi Y, Hirunagi T, Katsuno M, Shindou H, Funayama M, Nishioka K, Hattori N, Imai Y.
- Journal Title
  
  Mov Disord.
  
  Volume: 37 Issue: 10 Pages: 2075-2085
- DOI
  10.1002/mds.29162
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07910, KAKENHI-PROJECT-21K07424, KAKENHI-PROJECT-22K07542, KAKENHI-PROJECT-20K16160, KAKENHI-PROJECT-22K15649, KAKENHI-PROJECT-21H04820, KAKENHI-PROJECT-20H03453, KAKENHI-PROJECT-20K07893, KAKENHI-PROJECT-20K21531, KAKENHI-PROJECT-21K19443
[Journal Article] Parkinson disease-associated Leucine-rich repeat kinase regulates UNC-104-dependent axonal transport of Arl8-positive vesicles in Drosophila.2022
- Author(s)
  Inoshita T, Liu J-Y, Taniguchi D, Ishii R, Shiba-Fukushima K, Hattori N, Imai Y.
- Journal Title
  
  iScience
  
  Volume: 25 Issue: 12 Pages: 105476-105476
- DOI
  10.1016/j.isci.2022.105476
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07910, KAKENHI-PROJECT-22K06916, KAKENHI-PROJECT-21H04820, KAKENHI-PROJECT-20H03453, KAKENHI-PROJECT-19K07830, KAKENHI-PROJECT-20K21531
[Journal Article] Pathophysiological evaluation of the LRRK2 G2385R risk variant for Parkinson’s disease.2022
- Author(s)
  Tezuka T, Taniguchi D, Sano M, Shimada T, Oji Y, Tsunemi T, Ikeda A, Li Y, Yoshino H, Ogata J, Shiba-Fukushima K, Funayama M, Nishioka K, Imai Y, Hattori N.
- Journal Title
  
  NPJ Parkinsons Dis.
  
  Volume: 8 Issue: 1 Pages: 97-97
- DOI
  10.1038/s41531-022-00367-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07910, KAKENHI-PROJECT-21K07283, KAKENHI-PROJECT-21K07444, KAKENHI-PROJECT-22K07542, KAKENHI-PROJECT-22K15649, KAKENHI-PROJECT-20H03453, KAKENHI-PROJECT-20K07893, KAKENHI-PROJECT-20K21531
[Journal Article] Monitoring PINK1-Parkin Signaling Using from iPS Cells2021
- Author(s)
  Shiba-Fukushima Kahori、Imai Yuzuru
- Journal Title
  
  Methods Mol Biol.
  
  Volume: 2322 Pages: 81-92
- DOI
  10.1007/978-1-0716-1495-2_9
- ISBN
  9781071614945, 9781071614952
- Data Source
  KAKENHI-PROJECT-20K07910
[Journal Article] Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)12021
- Author(s)
  Daniel J Klionsky、Shu Aizawa、Amal Kamal Abdel-Aziz、Sara Abdelfatah、Mahmoud Abdellatif、Asghar Abdoli、Steffen Abel、Hagai Abeliovich、Marie H Abildgaard、Yakubu Princely Abudu、Abraham Acevedo-Arozena、Iannis E Adamopoulos、Khosrow Adeli、Timon E Adolph、Annagrazia Adornetto、Elma Aflaki、Galila Agam et al.
- Journal Title
  
  Autophagy
  
  Volume: 17 Issue: 1 Pages: 1-382
- DOI
  10.1080/15548627.2020.1797280
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06375, KAKENHI-PROJECT-19K07568, KAKENHI-PROJECT-20K06501, KAKENHI-PROJECT-20K06636, KAKENHI-PROJECT-20K07896, KAKENHI-PROJECT-20K21769, KAKENHI-PLANNED-20H05772, KAKENHI-PROJECT-19H01042, KAKENHI-PROJECT-18H02439, KAKENHI-PROJECT-18H02656, KAKENHI-PROJECT-18H02807, KAKENHI-PROJECT-20J00363, KAKENHI-PROJECT-18K06210, KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-18K08079, KAKENHI-PROJECT-18K09427, KAKENHI-PROJECT-19K08851, KAKENHI-PROJECT-18KK0193, KAKENHI-PLANNED-19H05710, KAKENHI-PROJECT-18H02901, KAKENHI-PROJECT-20H02990, KAKENHI-PUBLICLY-20H05504, KAKENHI-PROJECT-19H03471, KAKENHI-PROJECT-19H03791, KAKENHI-PROJECT-20H03249, KAKENHI-PROJECT-19K09677, KAKENHI-PROJECT-20K07910, KAKENHI-PROJECT-20K08460, KAKENHI-PROJECT-20K08662, KAKENHI-PROJECT-21K07926, KAKENHI-PROJECT-20K21531, KAKENHI-PROJECT-19K24690, KAKENHI-PROJECT-23K21397
[Journal Article] A Cell-Based High-Throughput Screening Identified Two Compounds that Enhance PINK1-Parkin Signaling2020
- Author(s)
  Shiba-Fukushima Kahori、Inoshita Tsuyoshi、Sano Osamu、Iwata Hidehisa、Ishikawa Kei-ichi、Okano Hideyuki、Akamatsu Wado、Imai Yuzuru、Hattori Nobutaka
- Journal Title
  
  iScience
  
  Volume: 23 Issue: 5 Pages: 101048-101048
- DOI
  10.1016/j.isci.2020.101048
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07873, KAKENHI-PROJECT-20K07910, KAKENHI-PROJECT-17H04049, KAKENHI-PROJECT-17K09765
[Journal Article] Reduced astrocytic reactivity in human brains and midbrain organoids with PRKN mutations2020
- Author(s)
  Kano Masayoshi、Takanashi Masashi、Oyama Genko、Yoritaka Asako、Hatano Taku、Shiba-Fukushima Kahori、Nagai Makiko、Nishiyama Kazutoshi、Hasegawa Kazuko、Inoshita Tsuyoshi、Ishikawa Kei-ichi、Akamatsu Wado、Imai Yuzuru、Bolognin Silvia、Schwamborn Jens Christian、Hattori Nobutaka
- Journal Title
  
  npj Parkinson's Disease
  
  Volume: 6 Issue: 1 Pages: 33-33
- DOI
  10.1038/s41531-020-00137-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07873, KAKENHI-PROJECT-20K07910, KAKENHI-PROJECT-17H04049, KAKENHI-PROJECT-18H04043, KAKENHI-PROJECT-17K09765
[Journal Article] Identifying Therapeutic Agents for Amelioration of Mitochondrial Clearance Disorder in Neurons of Familial Parkinson Disease2020
- Author(s)
  Yamaguchi Akihiro、Ishikawa Kei-ichi、Inoshita Tsuyoshi、Shiba-Fukushima Kahori、Saiki Shinji、Hatano Taku、Mori Akio、Oji Yutaka、Okuzumi Ayami、Li Yuanzhe、Funayama Manabu、Imai Yuzuru、Hattori Nobutaka、Akamatsu Wado
- Journal Title
  
  Stem Cell Reports
  
  Volume: 14 Issue: 6 Pages: 1060-1075
- DOI
  10.1016/j.stemcr.2020.04.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08003, KAKENHI-PROJECT-20K07873, KAKENHI-PROJECT-20K07910, KAKENHI-PROJECT-17H04049, KAKENHI-PROJECT-18H04043, KAKENHI-PROJECT-17K09765
[Journal Article] Twin CHCH Proteins, CHCHD2, and CHCHD10: Key Molecules of Parkinson’s Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia2019
- Author(s)
  Imai Yuzuru、Meng Hongrui、Shiba-Fukushima Kahori、Hattori Nobutaka
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Issue: 4 Pages: 908-908
- DOI
  10.3390/ijms20040908
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15465, KAKENHI-PROJECT-18H04043, KAKENHI-PROJECT-17H04049, KAKENHI-PROJECT-16K19525
[Journal Article] Syntaxin 17 regulates the localization and function of PGAM5 in mitochondrial division and mitophagy2018
- Author(s)
  Sugo Masashi、Kimura Hana、Arasaki Kohei、Amemiya Toshiki、Hirota Naohiko、Dohmae Naoshi、Imai Yuzuru、Inoshita Tsuyoshi、Shiba‐Fukushima Kahori、Hattori Nobutaka、Cheng Jinglei、Fujimoto Toyoshi、Wakana Yuichi、Inoue Hiroki、Tagaya Mitsuo
- Journal Title
  
  The EMBO Journal
  
  Volume: 37 Issue: 21
- DOI
  10.15252/embj.201798899
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06138, KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05902, KAKENHI-PROJECT-18H04023, KAKENHI-PROJECT-18H04043, KAKENHI-PROJECT-17H04049, KAKENHI-PROJECT-18H02439, KAKENHI-PROJECT-18H02656
[Journal Article] Reduced TDP-43 Expression Improves Neuronal Activities in a Drosophila Model of Perry Syndrome2017
- Author(s)
  Hosaka Y, Inoshita T, Shiba-Fukushima K, Cui C, Arano T, Imai Y, Hattori N
- Journal Title
  
  EBioMedicine
  
  Volume: 21 Pages: 218-227
- DOI
  10.1016/j.ebiom.2017.06.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293070
[Journal Article] 遺伝子から探るパーキンソン病病態へのミトコンドリアの関与2017
- Author(s)
  今居　譲、柴佳保里、服部信孝
- Journal Title
  
  医学のあゆみ
  
  Volume: 260 Pages: 85-91
- Data Source
  KAKENHI-PROJECT-26293070
[Journal Article] 遺伝子から探るパーキンソン病病態へのミトコンドリアの関与2017
- Author(s)
  今居　譲、柴佳保里、服部信孝
- Journal Title
  
  医学のあゆみ
  
  Volume: 260 Pages: 85-91
- Data Source
  KAKENHI-PROJECT-16K15484
[Journal Article] Evidence that phosphorylated ubiquitin signaling is involved in the etiology of Parkinson’s disease2017
- Author(s)
  Shiba-Fukushima Kahori、Ishikawa Kei-Ichi、Inoshita Tsuyoshi、Izawa Nana、Takanashi Masashi、Sato Shigeto、Onodera Osamu、Akamatsu Wado、Okano Hideyuki、Imai Yuzuru、Hattori Nobutaka
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 26 Pages: 3172-3185
- DOI
  10.1093/hmg/ddx201
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09677, KAKENHI-PROJECT-17K09765, KAKENHI-PROJECT-26293070, KAKENHI-PROJECT-15H04842, KAKENHI-PROJECT-26461280, KAKENHI-PROJECT-16K15484, KAKENHI-PROJECT-16K19524, KAKENHI-PUBLICLY-17H05706
[Journal Article] Loss of Parkinson's disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c.2017
- Author(s)
  Meng H, Yamashita C, Shiba-Fukushima K, Inoshita T, Funayama M, Sato S, Hatta T, Natsume T, Umitsu M, Takagi J, Imai Y, Hattori N.
- Journal Title
  
  Nat Commun
  
  Volume: 8 Issue: 1 Pages: 15500-15500
- DOI
  10.1038/ncomms15500
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09676, KAKENHI-PROJECT-16K19525, KAKENHI-PROJECT-26293070, KAKENHI-PROJECT-15H04842, KAKENHI-PROJECT-15KK0354, KAKENHI-PROJECT-17H01420
[Journal Article] Current Topics「PINK1とParkinが紡ぐリン酸化ポリユビキチンの鎖が、Parkinをミトコンドリアへと局在化させる」2015
- Author(s)
  今居　譲、柴佳保里、服部信孝
- Journal Title
  
  実験医学
  
  Volume: 33 Pages: 940-943
- Data Source
  KAKENHI-PROJECT-26293070
[Journal Article] PINK1-mediated phosphorylation of Parkin boosts Parkin activity in Drosophila.2014
- Author(s)
  Shiba-Fukushima K, Inoshita T, Hattori N, Imai Y.
- Journal Title
  
  PLoS Genet.
  
  Volume: Jun 5;10(6) Issue: 6 Pages: 1004391-1004391
- DOI
  10.1371/journal.pgen.1004391
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23111003, KAKENHI-PROJECT-24390224, KAKENHI-PROJECT-24790896, KAKENHI-PUBLICLY-26117727, KAKENHI-PROJECT-26293070, KAKENHI-PROJECT-26461280, KAKENHI-PROJECT-26860219
[Journal Article] Lysine 63-linked polyubiquitination is dispensable for Parkin-mediated mitophagy.2014
- Author(s)
  Shiba-Fukushima K, Inoshita T, Hattori N, Imai Y.
- Journal Title
  
  J Biol Chem.
  
  Volume: 289 Issue: 48 Pages: 33131-6
- DOI
  10.1074/jbc.c114.580944
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23111003, KAKENHI-PROJECT-24390224, KAKENHI-PUBLICLY-26117727, KAKENHI-PROJECT-26293070, KAKENHI-PROJECT-26461280
[Journal Article] Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering.2014
- Author(s)
  Shiba-Fukushima K, Arano T, Matsumoto G, Inoshita T, Yoshida S, Ishihama Y, Ryu KY, Nukina N, Hattori N, Imai Y.
- Journal Title
  
  PLoS Genet.
  
  Volume: 10 Issue: 12 Pages: 1004861-1004861
- DOI
  10.1371/journal.pgen.1004861
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23111003, KAKENHI-PROJECT-23500434, KAKENHI-PROJECT-24241062, KAKENHI-PROJECT-24390224, KAKENHI-PUBLICLY-26117727, KAKENHI-PROJECT-26293070, KAKENHI-PROJECT-26461280, KAKENHI-PROJECT-26860219
[Journal Article] Tricornered/NDR kinase signaling mediates PINK1-directed mitochondrial quality control and tissue maintenance2013
- Author(s)
  Wu Z, Sawada T, Shiba K, Liu S, Kanao T, Takahasi R, Hattori N, Imai Y, Lu B
- Journal Title
  
  Genes Dev.
  
  Volume: 27(2) Pages: 157-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790896
[Journal Article] Tricornered/NDR kinase signaling mediates PINK1-directed mitochondrial quality control and tissue maintenance2013
- Author(s)
  Wu Z, Sawada T, Shiba K, Liu S, Kanao T, Takahashi R, Hattori N, Imai Y, Lu B. .
- Journal Title
  
  Genes Dev.
  
  Volume: 27 Issue: 2 Pages: 157-62
- DOI
  10.1101/gad.203406.112
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23111003, KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-23790973, KAKENHI-PROJECT-24790896
[Journal Article] PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria2012
- Author(s)
  尾勝圭
- Journal Title
  
  Nature Communications
  
  Volume: 3 Issue: 1 Pages: 1016-1016
- DOI
  10.1038/ncomms2016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J06061, KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-22370042, KAKENHI-PROJECT-22370071, KAKENHI-PROJECT-23570231, KAKENHI-PROJECT-23570232, KAKENHI-PROJECT-23687018, KAKENHI-PROJECT-24657138, KAKENHI-PROJECT-24790896, KAKENHI-PLANNED-23111003, KAKENHI-PUBLICLY-23129506, KAKENHI-PUBLICLY-24111557, KAKENHI-PUBLICLY-24113717
[Journal Article] PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy2012
- Author(s)
  Kahori Shiba-Fukushima
- Journal Title
  
  Scientific Reports
  
  Volume: 2 Issue: 1 Pages: 1002-1002
- DOI
  10.1038/srep01002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790973, KAKENHI-PROJECT-23890206, KAKENHI-PROJECT-24659017, KAKENHI-PROJECT-24790896, KAKENHI-PLANNED-23111003, KAKENHI-PUBLICLY-24116513
[Journal Article] PINK1 recruits Parkin to damaged mitochondria for degradation.2010
- Author(s)
  Matsuda N, Sato S, Shiba K, et al.
- Journal Title
  
  The Journal of cell biology (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790627
[Journal Article] PINK1 stabilized by mitochondrial depokarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy2010
- Author(s)
  Matsuda N, Sato S, Shiba K, Okatsu K, Saisho K, Gautier CA, Sou YS, Saiki S, Kawajiri S, Sato F, Kimura M, Komatsu M, Hattori N, Tanaka K.
- Journal Title
  
  J Csll Biol 189(2)
  
  Pages: 211-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790627
[Journal Article] Parkn stabilizes PINK1 through direct interaction.2009
- Author(s)
  Shiba K, Arai T, Sato S, et al.
- Journal Title
  
  Biochem Biophys Res Commun. 383(3)
  
  Pages: 331-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790627
[Journal Article] Parkin stabilizes PINK1 through direct interaction2009
- Author(s)
  Shiba K, Arai T, Sato S, Kubo S, Oba Y, Mizuno Y, Hattori N.
- Journal Title
  
  Biochem Biophys Res Commun 383(3)
  
  Pages: 331-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790627
[Journal Article] Programmed cell death-2 isoform1 is ubiquitinated by parkin and increased in the substantia nigra of patients with autosomal recessive Parkinson's disease
- Author(s)
  Fukae J, Sato S, Shiba K, Sato K, Mori H, Sharp PA, Mizuno Y, Hattori N.
- Journal Title
  
  FEBS Lett. 583(3)
  
  Pages: 521-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790627
[Presentation] Drosophila VPS13 regulates neuronal synaptic activity and mitochondrial homeostasis.2022
- Author(s)
  Shiba-Fukushima K, Inoshita T, Imai Y, Hattori N
- Organizer
  Neuro2022
- Data Source
  KAKENHI-PROJECT-20H03453
[Presentation] Ubiquitination at the lysine 27 residue of the Parkin ubiquitin-like domain is suggestive of a new mechanism of Parkin activation.2022
- Author(s)
  Liu J-Y, Inoshita T, Shiba-Fukushima K, Hattori N, Imai Y
- Organizer
  Neuro2022
- Data Source
  KAKENHI-PROJECT-20H03453
[Presentation] Screening of lipid species and associated enzymes that participate in α-synuclein aggregation.2022
- Author(s)
  Kasahara R, Ogata J, Shiina K, Shiba-Fukushima K, Inoshita T, Hattori N, Imai Y
- Organizer
  MBSJ2022
- Data Source
  KAKENHI-PROJECT-20H03453
[Presentation] Two novel variants in CHCHD2 associate with TDP-43 pathology among amyotrophic lateral sclerosis.2022
- Author(s)
  Ikeda A, Funayama M, Yoshida M, Li Y, Inoshita T, Shiba-Fukushima K, Meng H, Amo T, Aiba I, Saito Y, Atsuta N, Nakamura R, Tohnai G, Sone J, Izumi Y, Kaji R, Morita M, Taniguchi A, Nishioka K, Imai Y, Sobue G, Hattori N, JaCALS
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20H03453
[Presentation] Parkin活性化剤の探索2019
- Author(s)
  柴佳保里、井下強、今居譲、服部信孝
- Organizer
  第42回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-17K09765
[Presentation] Parkin活性化剤の探索2018
- Author(s)
  福嶋佳保里
- Organizer
  第41回分子生物学会
- Data Source
  KAKENHI-PROJECT-17K09765
[Presentation] PINK1-Parkinシグナル伝達に関与する新規分子の解析2018
- Author(s)
  福嶋佳保里
- Organizer
  第41回　神経科学学会
- Data Source
  KAKENHI-PROJECT-17K09765
[Presentation] PINK1-Parkinシグナル伝達に関与する新規分子の解析2017
- Author(s)
  柴佳保里、井下強、青木裕子、石濱泰、今居譲、服部信孝
- Organizer
  第40回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K09765
[Presentation] PINK1-Parkinシグナル伝達に関与する新規分子の解析2017
- Author(s)
  柴佳保里、井下強、青木裕子、石濱泰、今居譲、服部信孝
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-17H04049
[Presentation] Reduced TDP-43 expression improves axonal transport and synaptic activity in a Drosophila model of Perry syndrome2017
- Author(s)
  Hosaka Y, Inoshita T, Cui C, Arano T, Shiba K, Imai Y, Hattori H
- Organizer
  World Congress of Neurology
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] PINK1-Parkinシグナル伝達に関与する新規分子の解析2017
- Author(s)
  柴佳保里、井下強、青木裕子、石濱泰、今居譲、服部信孝
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] PINK1-Parkinシグナル伝達に関与する新規分子の解析2017
- Author(s)
  柴佳保里、井下強、青木裕子、石濱泰、今居譲、服部信孝
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-16K15484
[Presentation] Loss of Parkinson’s disease-associated protein CHCHD2 affects mitochondrial cristae structure and facilitates cytochrome c release from mitochondria2017
- Author(s)
  Meng H, Yamashita C, Shiba-Fukushima K, Inoshita T, Imai Y, Hattori N
- Organizer
  第40回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] CHCHD2, a Parkinson's-Disease Associated Protein, Regulates the Mitochondrial cristae integrity and function in Drosophila2016
- Author(s)
  Meng H, Yamashita C, Shiba-Fukushima K, Inoshita T, Imai Y, Hattori N
- Organizer
  第39回日本神経学会学術大会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] Evidence that phosphorylated ubiquitin signaling is involved in the etiology of Parkinson’s disease.2016
- Author(s)
  Shiba K, Ishikawa K, Inoshita T, Akamatsu W, Hideyuki O, Imai Y, Hattori N
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26461280
[Presentation] Loss of Parkinson’s disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c.2016
- Author(s)
  Meng H, Yamashita C, Shiba-Fukushima K, Inoshita T, Funayama M, Sato S, Imai Y, Hattori N
- Organizer
  第39回日本分子生物学会年会　シンポジウム
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] パーキンソン病新規原因遺伝子CHCHD2の機能解析2016
- Author(s)
  山下力、孟　紅蕊、井下強、福嶋佳保里、荒野拓、佐藤栄人、今居譲、服部信孝
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸市
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] In vivo evidence for the involvement of phospho-ubiquitin signal.2016
- Author(s)
  Shiba K, Ishikawa K, Takanashi M, Akamatsu W, Imai Y, Hattori N
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2016-07-22
- Data Source
  KAKENHI-PROJECT-26461280
[Presentation] In vivo evidence for the involvement of phospho-ubiquitin signal2016
- Author(s)
  Shiba-Fukushima K, Ishikawa K-I, Takanashi M, Akamatsu W, Imai Y, Hattori N
- Organizer
  第39回日本神経学会学術大会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] Evidence that phosphorylated ubiquitin signaling is involved in the etiology of Parkinson's disease2016
- Author(s)
  Shiba-Fukushima K, Ishikawa K-I, Takanashi M, Akamatsu W, Imai Y, Hattori N
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] Phosphorylation of Mitochondrial Polyubiquitin by PINK1 Promotes Parkin Mitochondrial Tethering2015
- Author(s)
  Shiba-Fukushima K, Arano T, Matsumoto G, Inoshita T, Yoshida S, Ishihama Y, Ryu K-K, Nukina N, Imai Y, Hattori N
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  朱鷺メッセ（新潟県新潟市）
- Year and Date
  2015-05-23
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] PINK1-Parkinシグナルによるミトコンドリアの品質管理機構2015
- Author(s)
  柴佳保里
- Organizer
  第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-02
- Invited
- Data Source
  KAKENHI-PROJECT-26461280
[Presentation] Phosphorylation of Mitochondrial K63-Linked Polyubiquitin by PINK1 Promotes Parkin Mitochondrial Tethering2015
- Author(s)
  福嶋佳保里
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  新潟コンベンションセンター
- Year and Date
  2015-05-23
- Data Source
  KAKENHI-PROJECT-26461280
[Presentation] Mutations of a mitochondrial protein CHCHD2 in Drosophila lead to Parkinson’s disease-like phenotypes2015
- Author(s)
  Meng H, Yamashita C, Shiba-Fukushima K, Hattori N, Imai Y
- Organizer
  Cell Symposia
- Place of Presentation
  シカゴ
- Year and Date
  2015-07-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] PINK1-Parkinミトコンドリア品質管理機構に関与する分子の探索2014
- Author(s)
  柴佳保里、井下　強、梅崎勇次郎、今居　譲、服部信孝
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡国際会議場（福岡県・福岡市）
- Year and Date
  2014-05-23
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] Lysine 63-linked polyubiquitination is dispensable for Parkin-mediated mitophagy2014
- Author(s)
  Shiba-Fukushima K, Inoshita T, Hattori N, Imai Y
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2014-09-11
- Data Source
  KAKENHI-PROJECT-26461280
[Presentation] PINK1-Parkinミトコンドリア品質管理機構に関与する分子の探索2014
- Author(s)
  柴佳保里、井下　強、梅崎勇次郎、今居　譲、服部信孝
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡
- Year and Date
  2014-05-23
- Data Source
  KAKENHI-PROJECT-26461280
[Presentation] Lysine 63-linked polyubiquitination is dispensable for Parkin-mediated mitophagy2014
- Author(s)
  Shiba-Fukushima K, Inoshita T, Hattori N, Imai Y
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜）
- Year and Date
  2014-09-11
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] Parkinノックアウトマウスにおける放出機構の検討2013
- Author(s)
  江口博人、今泉美佳、塚口ケネス、福嶋佳保里、佐藤栄人、舩山学、斉木臣二、波田野琢、久保紳一郎、今居譲、永松信哉、服部信孝
- Organizer
  第54回日本神経学会学術大会、ポスター
- Place of Presentation
  東京
- Year and Date
  2013-05-30
- Data Source
  KAKENHI-PROJECT-24790896
[Presentation] PINK1依存的なParkinのリン酸化修飾はPINK1/Parkin経路マイトファジーに必要である2013
- Author(s)
  福嶋佳保里、今居譲、吉田繁治、石濱泰、金尾智子、佐藤栄人、服部信孝
- Organizer
  第54回日本神経学会学術大会
- Place of Presentation
  東京
- Year and Date
  2013-05-30
- Data Source
  KAKENHI-PROJECT-24790896
[Presentation] PINK1依存的なParkinのリン酸化修飾はPINK1/Parkin経路マイトファジーに必要である2013
- Author(s)
  福嶋佳保里、吉田繁治、石濱泰、今居譲、服部信孝
- Organizer
  日本分子生物学会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-24790896
[Presentation] PINK1によるParkinリン酸化の生理的意義2013
- Author(s)
  柴-福嶋佳保里、井下強、吉見建二、服部信孝、今居譲
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2013-12-03
- Data Source
  KAKENHI-PROJECT-24790896
[Presentation] PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin : aninitial step of mitophagy2012
- Author(s)
  Imai Y, Shiba-Fukushima K, Yoshida S, Ishihama Y,Hattori N
- Organizer
  第35回日本分子生物学会年会、ポスター
- Place of Presentation
  福岡
- Year and Date
  2012-12-11
- Data Source
  KAKENHI-PROJECT-24790896
[Presentation] PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin : aninitial step of mitophagy2012
- Author(s)
  Imai Y, Shiba-Fukushima K, Yoshida S, Ishihama Y,Hattori N
- Organizer
  第35回日本分子生物学会年会ワークショップ「オートファジーによる分解の諸相」
- Place of Presentation
  福岡
- Year and Date
  2012-12-11
- Data Source
  KAKENHI-PROJECT-24790896
[Presentation] PINK1結合因子とPINK1安定化機構の関与2009
- Author(s)
  柴佳保里、佐藤栄人、斉木臣二、服部信孝
- Organizer
  第50回日本神経学会総会
- Place of Presentation
  仙台国際センター
- Year and Date
  2009-05-21
- Data Source
  KAKENHI-PROJECT-20790627
[Presentation] 家族性パーキンソン病原因遺伝子産物PINK1結合因子の解析2009
- Author(s)
  柴佳保里
- Organizer
  第50回日本神経学会総会
- Place of Presentation
  仙台国際ヤンター
- Year and Date
  2009-05-21
- Data Source
  KAKENHI-PROJECT-20790627
[Presentation] ParkinによるPINK1安定化機構の解析2008
- Author(s)
  柴佳保里
- Organizer
  日本分子生物学年会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-20790627
[Presentation] PINK1依存的なParkinのリン酸化修飾は、Parkinのミトコンドリア移行とその後のマイトファジー反応に必要である
- Author(s)
  今居譲、柴佳保里、吉田繁治、石濱泰、服部信孝
- Organizer
  日本分子生物学会年会
- Place of Presentation
  福岡国際会議場・マリンメッセ福岡
- Data Source
  KAKENHI-PROJECT-24790896

1. INOSHITA Tsuyoshi (20601206)

# of Collaborated Projects: 6 results

# of Collaborated Products: 20 results
2. Imai Yuzuru (30321730)

# of Collaborated Projects: 5 results

# of Collaborated Products: 32 results
3. HATTORI Nobutaka (80218510)

# of Collaborated Projects: 2 results

# of Collaborated Products: 25 results
4. ARANO Taku (80750091)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
5. MENG Hongrui (90736498)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
6. ISHIHAMA Yasushi (30439244)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. AKAMATSU Wado (60338184)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. OHBA Yusuke (30333503)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. FUNAYAMA Manabu

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
10. 井上弘樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 石川景一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. 斉木臣二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 相澤修

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 尾勝圭

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

Shiba Kahori 柴 佳保里

SHIBA Kahori 柴 佳保里

福嶋 佳保里

KAHORI Shiba 柴 佳保里

Research Projects

Research Products

Co-Researchers

PINK1-Parkin介在性マイトファジーの分子機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Autophagy Regulation Mechanism by Parkinson's Disease Causal Gene Product VPS13CPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of intracellular environmental factors that produce a risk for alpha-Synuclein seeding

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional analysis of novel molecules involved in PINK1-Parkin-mediated mitophagyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Exploration of Parkinson disease-specific pathological background

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Drug screening to improve mitochondrial functions

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A study on the common pathogenesis of Parkinson's disease as a mitochondrial disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the mechanism of mitochondrial maintenance by Parkinson's disease gene productsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of molecular mechanism of mitochondrial quality control by PINK1-Parkin pathwayPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of PINK1 stabilization molecular mechanism by ParkinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 順天堂大脳神経内科ではこうしている 最新 パーキンソン病診療【電子版付】2021

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 認知症 発症前治療のために解明すべき分子病態は何か？ -劣性遺伝性若年性パーキンソン病(AR-JP)の臨床、病理、分子遺伝学2017

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 週刊 医学のあゆみ ミトコンドリア研究 UPDATE2017

Shiba Kahori 柴佳保里

SHIBA Kahori 柴佳保里

福嶋佳保里

KAHORI Shiba 柴佳保里

[Book] 順天堂大脳神経内科ではこうしている　最新パーキンソン病診療【電子版付】2021

[Book] 認知症　発症前治療のために解明すべき分子病態は何か？ -劣性遺伝性若年性パーキンソン病(AR-JP)の臨床、病理、分子遺伝学2017

[Book] 週刊　医学のあゆみ　ミトコンドリア研究 UPDATE2017

[Book] 別冊　医学のあゆみ　ミトコンドリア研究 UPDATE2017