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Iwatsubo Takeshi  岩坪 威

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IWATSUBO Takeshi  岩坪 威

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Researcher Number 50223409
Other IDs
Affiliation (Current) 2022: 東京大学, 大学院医学系研究科(医学部), 教授
Affiliation (based on the past Project Information) *help 2016 – 2022: 東京大学, 大学院医学系研究科(医学部), 教授
2015: 東京大学, 大学院医学系研究科, 教授
2014: 東京大学, 医学系研究科, 教授
2012 – 2014: 東京大学, 医学(系)研究科(研究院), 教授
2008 – 2011: The University of Tokyo, 大学院・医学系研究科, 教授 … More
2010: 東京大学, 医学系研究科, 教授
2009: 東京大学, 大学院・薬学系研究科, 教授
2008: 東京大学, 医学部・神経病理学部門
2007: The University of Tokyo, Graduate School of Pharmaceutical Sciences, Professor
2005 – 2006: 東京大学, 大学院薬学系研究科, 教授
1998 – 2005: 東京大学, 大学院・薬学系研究科, 教授
2004: 国立大学法人東京大学, 大学院・薬学系研究科, 教授
2004: University of Tokyo, School of Pharmaceutical Sciences, Department of Neuropathology and Neuroscience, Professor, 大学院薬学研究科, 教授
1997: 東京大学, 大学院・薬学系研究科, 助教授
1995 – 1996: 東京大学, 薬学部, 助教授
1995: 東京大学, 薬学部, 寄附講座教員(客員助教授)
1994: Dept of Pharmacy, Univ.of Tokyo, assoc.Prof., 薬学部, 客員助教授
1994: 東京大学, 薬学部, 寄附講座教員
1993: 東京大学, 薬剤部, 客員助教授
1993: 東京大学, 薬学部, 寄附講座教員(客員助教授) Less
Review Section/Research Field
Principal Investigator
Biological Sciences / Neurology / Neurochemistry/Neuropharmacology / Neurology / Nerve anatomy/Neuropathology / Neurochemistry/Neuropharmacology / Medium-sized Section 52:General internal medicine and related fields
Except Principal Investigator
Biological Sciences / Neurology / Neurology / Neurochemistry/Neuropharmacology / 広領域 / Nerve anatomy/Neuropathology
Keywords
Principal Investigator
パーキンソン病 / アルツハイマー病 / Lewy小体 / βアミロイド / Lewy小体型痴呆症 / 脳神経疾患 / アルツハイマー / α-Synuclein / アミロイド / Alzheimer's disease … More / Aβ / ダウン症 / β蛋白 / Lewy body / α-シヌクレイン / αシヌクレイン / 神経変性 / リン酸化 / 老化 / プレセニリン / γ-secretase / 神経変性疾患 / Alzheimer / γセクレターゼ / タウ蛋白 / 胎児脳 / 老人斑 / モノクローナル抗体 / ユビキチン / 神経病理学 / 汎発生Lewy小体病 / ニューロフィラメント / モノクローン抗体 / α-synuclein / α-ミヌクレイン / Lew小体 / 生化学マーカー / 髄液診断 / LRRK2 / キナーゼ活性 / 遺伝子 / プロテインキナーゼ / 神経化学 / アミロイドβペプチド / シナプス / 光遺伝学 / 神経活動 / マイクロダイアリシス / 免疫細胞化学 / beta-amyloid / Aβ42 / presenilin / amyloid β peptide / ユビキチン化 / 神経細胞化 / 神経科学 / Lewy小体痴呆症 / Parkinson's disease / a-synuclein / phosphorylation / ubiquitination / neuronal death / 膜結合型コラーゲン / CLAC / collagen / amyloid / γセレクターゼ / Presenilin / β-amyloid / 結合タンパク / γ-Secretase / Amyloid / amyloid binding protein / 脳インスリン抵抗性 / アミロイドβ / タウ / amyloid beta peptide / tau / 液・液相分離 … More
Except Principal Investigator
脳科学 / 変性疾患 / 精神疾患 / タウオパチー / 神経変性疾患 / Multiple system atrophy / DRPLA / Huntington disease / アルツハイマー病 / Cdk5 / 統合脳 / 病態脳 / 神経疾患 / 紀伊半島 / 筋萎縮性側索硬化症 / パーキンソン認知症複合 / 遺伝子 / アルツハイマー神経原線維変化 / TDP-43 / 酸化ストレス / タウ蛋白 / 認知症 / パーキンソン症候群 / グアム島 / シナプス / 病態 / 発達障害 / 神経回路 / 分子 / サーキット / 分子病態 / ニューロサーキット / パソロジー / 治療 / 分子イメージング / 幹細胞 / glial cytoplasmic inclusion / carboxylmethyl trausferase / 多系統萎縮症 / glial cytoplasmic mclusion / αB-Crystallin / エビキチン / ユビキチン / glial cytoplamic inclusion / carboxyl methyl transferase / β蛋白 / 老人斑 / アミロイドβ蛋白 / 髄膜 / 定量 / β-amylodogenesis / diffuse plaque / preamyloid / GM1ガングリオシド / Alzheimer's Disease / amyloidbeta-protein / senile plaque / D-アミノ酸 / 哺乳類 / 生合成 / ラセマーゼ / 酸化酵素 / 細菌 / 脱水素酵素 / 標識試薬 / D-amino acid / mammals / biosynthesis / racemase / oxidase / bacteria / dehydrogenase / labeling reagent / タウ / 微小管 / リン酸化 / スプライシング / CdKS / 脳神経疾患 / 痴呆 / 老化 / プロテオーム / 蛋白質 / FTDP-17 / 前頭側頭型痴呆 / p35 / PHF / Tau / Phosphorylation / splicing / α-synuclein / Neurodegenrative disease / 研究支援 / 研究集会 / 研究リソース / 技術開発 / 若手研究者育成支援 / 研究リソース支援 / 技術開発支援 / ブレインバンク / 脳画像データベース / モデル動物 / 脳分子プロファイル / ウイルスベクター Less
  • Research Projects

    (30 results)
  • Research Products

    (111 results)
  • Co-Researchers

    (181 People)
  •  神経変性疾患におけるストレス依存的な凝集タンパク質の生成・放出機構Principal Investigator

    • Principal Investigator
      岩坪 威
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 52:General internal medicine and related fields
    • Research Institution
      The University of Tokyo
  •  Elucidation of the molecular mechanisms of Abeta economy in the brain of Alzheimer's diseasePrincipal Investigator

    • Principal Investigator
      Iwatsubo Takeshi
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      The University of Tokyo
  •  Insulin paradox and novel drug target in Alzheimer's disease.Principal Investigator

    • Principal Investigator
      Iwatsubo Takeshi
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Neurology
    • Research Institution
      The University of Tokyo
  •  Foundation of Synapse and Neurocircuit Pathology

    • Principal Investigator
      OKAZAWA Hitoshi
    • Project Period (FY)
      2010 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University
  •  Elucidation of the molecular pathology of Alzheimer's disease focusing on the synapses toward therapiesPrincipal Investigator

    • Principal Investigator
      IWATSUBO Takeshi
    • Project Period (FY)
      2010 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Comprehensive Brain Science Network

    • Principal Investigator
      Kimura Minoru
    • Project Period (FY)
      2010 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Research Institution
      Center for Novel Science Initatives, National Institutes of Natural Sciences
  •  Molecular biological study on the cause and pathogenesis of amyotrophic lateral sclerosis and parkinsonism-dementia complex of the Kii peninsula of Japan

    • Principal Investigator
      KUZUHARA Shigeki
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      National Center of Neurology and Psychiatry
      Mie University
  •  Molecular pathogenesis of Parkinson's diseasePrincipal Investigator

    • Principal Investigator
      IWATSUBO Takeshi
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Molecular and cell biological studies on the production, aggregation and clearance of Alzheimer amyloid β peptides.Principal Investigator

    • Principal Investigator
      IWATSYBO Takeshi
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      The University of Tokyo
  •  Research on Pathomechanisms of Brain Disorders

    • Principal Investigator
      NUKINA Nobuyuki
    • Project Period (FY)
      2004 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The Institute of Physical and Chemical Research
  •  Analysis of presenilin/γ-secretase complex responsible for the generation of Aβ in Alzheimer's diseasePrincipal Investigator

    • Principal Investigator
      IWATSUBO Takeshi
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      The University of Tokyo
  •  α-Synucleinopathyの病態解析に基づく神経細胞死の制御Principal Investigator

    • Principal Investigator
      岩坪 威
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      The University of Tokyo
  •  脳脊髄液中α-synuclein微量測定による神経変性疾患診断方法開発の試みPrincipal Investigator

    • Principal Investigator
      岩坪 威
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Neurology
    • Research Institution
      The University of Tokyo
  •  Title "Molecular Pathogenesis of Parkinson's Disease"Principal Investigator

    • Principal Investigator
      IWATSUBO Takeshi
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      University of Tokyo
  •  Development of diagnostic and therapeutic strategies for Alzheimer's disease : focus on a novel cerebral amyloid componentPrincipal Investigator

    • Principal Investigator
      IWATSUBO Takeshi
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      The University of Tokyo
  •  Biochemical characterization of tau in tauopaty brains

    • Principal Investigator
      HASEGAWA Masato
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
      The University of Tokyo
  •  αーシヌクレインの凝集・蓄積と神経細胞死Principal Investigator

    • Principal Investigator
      岩坪 威
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      The University of Tokyo
  •  Lewy小体病発症におけるα-シヌクレインの役割Principal Investigator

    • Principal Investigator
      岩坪 威
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      The University of Tokyo
  •  Extensive research on D-amino acids present in mammals

    • Principal Investigator
      IMAI Kazuhiro
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      広領域
    • Research Institution
      The Universityof Tokyo
  •  MOLECULAR PATHOLOGICAL STUDIE OF ALZHEIMER'S DISEASE : ROLE OF β-AMYLOID AND PRESENILINSPrincipal Investigator

    • Principal Investigator
      IWATSUBO Takeshi
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      UNIVERSITY OF TOKYO
  •  Lewy小体のpathobiologyPrincipal Investigator

    • Principal Investigator
      岩坪 威
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  Lewy小体の分子病理学的解析Principal Investigator

    • Principal Investigator
      岩坪 威
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  Lewy小体構成分子の解析Principal Investigator

    • Principal Investigator
      岩坪 威
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  Studies on beta-amyloidogenesis-isolation of membrane-bound Abeta

    • Principal Investigator
      IHARA Yasuo
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      University of Tokyo
  •  Immunocytochemical studies on beta-amyloidogenesisPrincipal Investigator

    • Principal Investigator
      IWATSUBO Takeshi
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      University of Tokyo
  •  アルツハイマー脳におけるPHF形成機序に関する研究Principal Investigator

    • Principal Investigator
      岩坪 威
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  Lewy小体構成分子の同定Principal Investigator

    • Principal Investigator
      岩坪 威
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  Lewy小体の単離精製と構成成分の解析Principal Investigator

    • Principal Investigator
      岩坪 威
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  PHFを構成する異常タウ蛋白の機能と形態に関する研究Principal Investigator

    • Principal Investigator
      岩坪 威
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  Biochemical study of glial cytoplasmic inclusions in multiple system atrophy brains

    • Principal Investigator
      NUKINA Nobuyuki
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      University of Tokyo, Faculty of medicine

All 2022 2021 2020 2019 2018 2017 2016 2015 2013 2012 2011 2010 2009 2008 2007 2006 2005 Other

All Journal Article Presentation

  • [Journal Article] Glymphatic system clears extracellular tau and protects from tau aggregation and neurodegeneration2022

    • Author(s)
      Ishida K, Yamada K, Nishiyama R, Hashimoto T, Nishida I, Abe Y, Yasui M, Iwatsubo T
    • Journal Title

      Journal of Experimental Medicine

      Volume: 219

    • DOI

      10.1084/jem.20211275

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H00525, KAKENHI-PROJECT-19J21850, KAKENHI-PROJECT-21K07270
  • [Journal Article] Differential involvement of insulin receptor substrate (IRS)-1 and IRS-2 in brain insulin signaling is associated with the effects of their deficiency on amyloid pathology in Alzheimer's disease.2021

    • Author(s)
      Ochiai T, Sano T, Kubota N, Kadowaki T, Wakabayashi T, Iwatsubo T
    • Journal Title

      Neurobiology of Disease

      Volume: 159 Pages: 105510-105510

    • DOI

      10.1016/j.nbd.2021.105510

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H00525
  • [Journal Article] Tauroursodeoxycholic acid attenuates diet-induced and age-related peripheral endoplasmic reticulum stress and cerebral amyloid pathology in a mouse model of Alzheimer’s disease.2021

    • Author(s)
      Ochiai T, Nagayama T, Matsui K, Amano K, Sano T, Wakabayashi T, Iwatsubo T
    • Journal Title

      J Prev Alzheimers Dis

      Volume: 4 Pages: 483-494

    • DOI

      10.14283/jpad.2021.33

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H00525
  • [Journal Article] Roles of lysosomotropic agents on LRRK2 activation and Rab10 phosphorylation.2020

    • Author(s)
      Kuwahara T., Funakawa K., Komori T., Sakurai M., Yoshii G., Eguchi T., Fukuda M., Iwatsubo T.
    • Journal Title

      Neurobiology of Disease

      Volume: 145 Pages: 105081-105081

    • DOI

      10.1016/j.nbd.2020.105081

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07816, KAKENHI-PROJECT-20H00525
  • [Journal Article] Collagenous Alzheimer amyloid plaque component impacts on the compaction of amyloid-β plaques.2020

    • Author(s)
      Hashimoto Tadafumi、Fujii Daisuke、Naka Yasushi、Kashiwagi-Hakozaki Mayu、Matsuo Yuko、Matsuura Yusuke、Wakabayashi Tomoko、Iwatsubo Takeshi
    • Journal Title

      Acta Neuropathologica Communications

      Volume: 8 Pages: 212-212

    • DOI

      10.1186/s40478-020-01075-5

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07364, KAKENHI-PROJECT-20H00525
  • [Journal Article] Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer's disease.2019

    • Author(s)
      Wakabayashi T, Yamaguchi K, Matsui K, Sano T, Kubota T, Hashimoto T, Mano A, Yamada K, Matsuo Y, Kubota N, Kadowaki T, Iwatsubo T
    • Journal Title

      Mol. Neurodegener.

      Volume: 14 Pages: 15-15

    • DOI

      10.1186/s13024-019-0315-7

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07364, KAKENHI-PROJECT-19K08991, KAKENHI-PROJECT-19H01052, KAKENHI-PROJECT-26000012, KAKENHI-PROJECT-17H04193, KAKENHI-PROJECT-18H02860
  • [Journal Article] Characterization of the unique in vitro effects of unsaturated fatty acids on the formation of amyloid beta fibrils2019

    • Author(s)
      Miki Eto, Tadafumi Hashimoto, Takao Shimizu, Takeshi Iwatsubo
    • Journal Title

      PLOS One

      Volume: 14

    • DOI

      10.1371/journal.pone.0219465

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07364, KAKENHI-PROJECT-17H04193
  • [Journal Article] Roles of Collagen XXV and Its Putative Receptors PTPσ/δ in Intramuscular Motor Innervation and Congenital Cranial Dysinnervation Disorder2019

    • Author(s)
      Haruka Munezane, Hiroaki Oizumi, Tomoko Wakabayashi, Shu Nishio, Tomoko Hirasawa, Takashi Sato, Akihiro Harada, Tomoyuki Yoshida, Takahiro Eguchi, Yuji Yamanashi, Tadafumi Hashimoto, Takeshi Iwatsubo
    • Journal Title

      Cell Reports

      Volume: 29 Pages: 4362-4376

    • DOI

      10.1016/j.celrep.2019.11.112

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07364, KAKENHI-PROJECT-19K06435, KAKENHI-ORGANIZER-17H06413, KAKENHI-PUBLICLY-19H04744, KAKENHI-PROJECT-17K07091, KAKENHI-PROJECT-17H01532, KAKENHI-PROJECT-17H04193
  • [Journal Article] Seeding activity-based detection uncovers the different release mechanisms of seed-competent tau versus inert tau via lysosomal exocytosis2019

    • Author(s)
      Yuki Tanaka, Kaoru Yamada, Kyoko Satake, Itaru Nishida, Matthias Heuberger, Tomoki Kuwahara, Takeshi Iwatsubo
    • Journal Title

      Frontiers in Neuroscience

      Volume: 13 Pages: 1258-1258

    • DOI

      10.3389/fnins.2019.01258

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07816, KAKENHI-PROJECT-19J21850, KAKENHI-PROJECT-17H04193
  • [Journal Article] Chronic cerebral hypoperfusion shifts the equilibrium of amyloid beta oligomers to aggregation-prone species with higher molecular weight2019

    • Author(s)
      Bannai Taro、Mano Tatsuo、Chen Xigui、Ohtomo Gaku、Ohtomo Ryo、Tsuchida Takeyuki、Koshi-Mano Kagari、Hashimoto Tadafumi、Okazawa Hitoshi、Iwatsubo Takeshi、Tsuji Shoji、Toda Tatsushi、Iwata Atsushi
    • Journal Title

      Scientific Reports

      Volume: 9 Pages: 1-11

    • DOI

      10.1038/s41598-019-39494-7

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07364, KAKENHI-PUBLICLY-17H05687, KAKENHI-PROJECT-16H05319, KAKENHI-PROJECT-17H04193, KAKENHI-PROJECT-17K16113, KAKENHI-PROJECT-16H02655
  • [Journal Article] Clinical and cognitive characteristics of preclinical Alzheimer's disease in the Japanese Alzheimer's Disease Neuroimaging Initiative cohort2018

    • Author(s)
      Ihara Ryoko、Iwata Atsushi、Suzuki Kazushi、Ikeuchi Takeshi、Kuwano Ryozo、Iwatsubo Takeshi
    • Journal Title

      Alzheimer's & Dementia: Translational Research & Clinical Interventions

      Volume: 4 Pages: 645-651

    • DOI

      10.1016/j.trci.2018.10.004

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09794, KAKENHI-PROJECT-17H04193
  • [Journal Article] Japanese and North American Alzheimer's Disease Neuroimaging Initiative studies: Harmonization for international trials2018

    • Author(s)
      Iwatsubo T, Iwata A, Suzuki K, Ihara R, Arai H, Ishii K, Senda M, Ito K, Ikeuchi T, Kuwano R, Matsuda H; Japanese Alzheimer's Disease Neuroimaging Initiative, Sun CK, Beckett LA, Petersen RC, Weiner MW, Aisen PS, Donohue MC; Alzheimer's Disease Neuroimaging Initiative
    • Journal Title

      Alzheimer's & Dementia

      Volume: S1552-5260 Pages: 1077-1087

    • DOI

      10.1016/j.jalz.2018.03.009

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K14649, KAKENHI-PROJECT-17K09794, KAKENHI-WRAPUP-18H05199, KAKENHI-PROJECT-17H04193
  • [Journal Article] Patterns and severity of vascular amyloid in Alzheimer’s disease associated with duplications and missense mutations in APP gene, Down syndrome and sporadic Alzheimer’s disease2018

    • Author(s)
      Mann David M. A.、Davidson Yvonne S.、Robinson Andrew C.、Allen Nancy、Hashimoto Tadafumi、Richardson Anna、Jones Matthew、Snowden Julie S.、Pendleton Neil、Potier Marie-Claude、Laquerri?re Annie、Prasher Vee、Iwatsubo Takeshi、Strydom Andre
    • Journal Title

      Acta Neuropathologica

      Volume: 136 Pages: 569-587

    • DOI

      10.1007/s00401-018-1866-3

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07364, KAKENHI-PUBLICLY-17H05687, KAKENHI-PROJECT-17H04193
  • [Journal Article] Chronic optogenetic activation augments Abeta pathology in a mouse model of Alzheimer disease.2015

    • Author(s)
      Kaoru Yamamoto, Zen-ichi Tanei, Tadafumi Hashimoto, Tomoko Wakabayashi, Hiroyuki Okuno, Yasushi Naka, Ofer Yizhar, Lief E. Fenno, Masashi Fukayama, Haruhiko Bito, John R. Cirrito, David M. Holtzman, Karl Deisseroth, Takeshi Iwatsubo
    • Journal Title

      Cell Rep

      Volume: 11 Pages: 859-865

    • DOI

      10.1016/j.celrep.2015.04.017

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-22110003, KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-15K08297, KAKENHI-PROJECT-15H02358
  • [Journal Article] Comprehensive phosphoproteome analysis unravels the core signaling network that initiates the earliest synapse pathology in preclinical Alzheimer's disease brain.2015

    • Author(s)
      Tagawa, K., H. Homma, A. Saito, K. Fujita, X. Chen, S. Imoto, T. Oka, H. Ito, K. Motoki, C. Yoshida, H. Hatsuta, Murayama, S., T. Iwatsubo, S. Miyano and H. Okazawa
    • Journal Title

      Hum Mol Genet

      Volume: 印刷中

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-221S0003
  • [Journal Article] Comprehensive phosphoproteome analysis unravels the core signaling network that initiates the earliest synapse pathology in preclinical Alzheimer's disease brain.2015

    • Author(s)
      Tagawa K, Homma H, Saito A, Fujita K, Chen X, Imoto S, Oka T, Ito H, Motoki K, Yoshida C, Hatsuta H, Murayama S, Iwatsubo T, Miyano S, Okazawa H.
    • Journal Title

      Hum Mol Genet

      Volume: 24 Pages: 540-558

    • DOI

      10.1093/hmg/ddu475

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-ORGANIZER-22110001, KAKENHI-PLANNED-22110002, KAKENHI-PROJECT-24500378, KAKENHI-PROJECT-26640037
  • [Journal Article] Activity-Dependent Proteolytic Cleavage of Neuroligin-12013

    • Author(s)
      Suzuki K, Hayashi Y, Nakahara S, Kumazaki H, Prox J, Horiuchi K, Zeng M, Tanimura S, Nishiyama Y, Osawa S, Sehara-Fujisawa A, Saftig P, Yokoshima S, Fukuyama T, Matsuki N, Koyama R, Tomita T, Iwatsubo T.
    • Journal Title

      Neuron

      Volume: 76(2) Pages: 410-22

    • DOI

      10.1016/j.neuron.2012.10.003

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J10924, KAKENHI-PROJECT-12J10970, KAKENHI-PLANNED-22110003, KAKENHI-PROJECT-22370076, KAKENHI-PROJECT-22390012, KAKENHI-PROJECT-24650171, KAKENHI-PROJECT-24657154, KAKENHI-PROJECT-24659028, KAKENHI-PLANNED-22122007, KAKENHI-PUBLICLY-24111511
  • [Journal Article] Phosphorylation of alpha-synuclein at Ser129 reduces neuronal dysfunction by lowering its membrane-binding property in Caenorhabditis elegans2012

    • Author(s)
      Kuwahara T, Tonegawa R, Ito G, Mitani S, Iwatsubo T
    • Journal Title

      Journal of Biological Chemistry

      Volume: 287 Pages: 7098-7109

    • DOI

      10.1074/jbc.m111.237131

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22110003, KAKENHI-PROJECT-22790058, KAKENHI-PROJECT-24790068
  • [Journal Article] Phenylpiperidine-typeγ-secretasemodulators target the transmembranedomain 1 of presenilin 12011

    • Author(s)
      Ohki Y, Higo T, Uemura K, Shimada N, Osawa S, Berezovska O, Yokoshima S, Fukuyama T, Tomita T, Iwatsubo T
    • Journal Title

      EMBO J

      Volume: 30巻 Pages: 4815-24

    • DOI

      10.1038/emboj.2011.372

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-10J10622, KAKENHI-PROJECT-11J04981, KAKENHI-PROJECT-19679001, KAKENHI-PLANNED-22110003
  • [Journal Article] Ku70 alleviates neurodegeneration in Drosophila models of Huntington's disease.2011

    • Author(s)
      Tamura, T., Sone, M., Iwatsubo, T., Tagawa, K., Wanker, E. E. and Okazawa, H
    • Journal Title

      PLoS one

      Volume: 6

    • DOI

      10.1371/journal.pone.0027408

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390265, KAKENHI-ORGANIZER-22110001, KAKENHI-PLANNED-22110002, KAKENHI-PROJECT-23500401
  • [Journal Article] BACE1 activity is modulated by cell-associated sphingosine-1-phosphate2011

    • Author(s)
      Takasugi N, Sasaki T, Suzuki K, Osawa S, Isshiki H, Hori Y, Shimada N, Higo T, Yokoshima S, Fukuyama T, Lee VM, Trojanowski JQ, Tomita T, Iwatsubo T
    • Journal Title

      Journal of Neuroscience

      Volume: 31 Pages: 6850-6857

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22110003
  • [Journal Article] A non-competitive BACE1 inhibitor TAK-070 ameliorates Aβ pathology and behavioral deficits in a mouse model of Alzheimer's disease.2010

    • Author(s)
      Fukumoto H, Takahashi H, Tarui N, Matsui J, Tomita T, Hirode M, Sagayama M, Maeda R, Kawamoto M, Hirai K, Terauchi J, Sakura Y, Kakihana M, Kato K, Iwatsubo T, Miyamoto M
    • Journal Title

      Journal of Neuroscience

      Volume: 30 Pages: 11157-11166

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22110003
  • [Journal Article] Participation of transmembrane domain 1 of presenilin 1 in the catalytic pore structure of the γ-secretase.2010

    • Author(s)
      Takagi S, Tominaga A, Sato C, Tomita T, Iwatsubo T
    • Journal Title

      Journal of Neuroscience

      Volume: 30 Pages: 15943-15950

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22110003
  • [Journal Article] Identification of the autophosphorylation sites of LRRK22009

    • Author(s)
      Kamikawaji S, Ito G, iwatsubo T
    • Journal Title

      Biochemistry 48

      Pages: 10963-10975

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17025009
  • [Journal Article] Identification of the autophosphorylation sites of LRRK2 linked to familial Parkinson's disease.2009

    • Author(s)
      Kamikawaji, S., Ito, G., Iwatsubo, T.
    • Journal Title

      Biochemistry 48

      Pages: 10963-10975

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17025009
  • [Journal Article] Hsp104 antagonizes asynuclein aggregation and reduces dopaminergic degenera tion in a rat model of Parkinson's disease2008

    • Author(s)
      Lo Bianco C, James Shorter C, Re gulier E, Lashuel H, Iwatsubo T, L indquist S, Aebischer P
    • Journal Title

      J Clin Invest 118

      Pages: 3087-3097

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17025009
  • [Journal Article] A large-scale RNA interference screen identifies endocytic pathway genes as modifiers of α-synuclein toxicity in transgenic Caenorhabditis elegans.2008

    • Author(s)
      Kuwahara, T, Koyama A., Koyama, S., Yoshina, S., Ren, C. -H., Kato, T., Mitani, S., Iwatsubo, T.
    • Journal Title

      Human Molecular Genetics 17 17

      Pages: 2997-3009

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17025009
  • [Journal Article] A large-scale RNA interference screen identifies endocytic pathway genes as m odifiers of asynuclein toxicity in transgenic Caenorhabditis elegans2008

    • Author(s)
      Kuwahara T, Koyama A, Koyama S, Yoshina S, Ren C-H, Kato T, M itani S, Iwatsubo T
    • Journal Title

      Human Molecular Genetics 17

      Pages: 2997-3009

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17025009
  • [Journal Article] Relationship of phosphorylated asynuclein and tau accumulation to Aβ deposit ion in the cerebral cortex of dementia with Lewy bodies2008

    • Author(s)
      Obi, K Akiyama H, Kondo H, Shi momura Y, Hasegawa M, Iwatsubo T. Mizuno Y, Mochizuki H
    • Journal Title

      Exp Neurol 210

      Pages: 409-420

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17025009
  • [Journal Article] GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease.2007

    • Author(s)
      Ito, G., Okai, T., Fujino, G., Takeda, K., Ichijo, H., Katada, T., Iwatsubo, T.
    • Journal Title

      Biochemistry 46

      Pages: 1380-1388

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17025009
  • [Journal Article] Aβ42 overproduction associated with structural changes in the catalytic pore of γ-secretase : common effects of Pen-2 amino-terminal elongation and fenofibrate2007

    • Author(s)
      Isoo N, Sato C, Miyashita H, Shinohara M, Takasugi N, Morohashi Y, Tsuji S, Tomita T^*, Iwatsubo T^*
    • Journal Title

      J Biol Chem 282

      Pages: 12388-12396

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Journal Article] Divergent synthesis of multifunctional molecular probes to elucidate the enzyme specificity of dipeptidic γ-secretase inhibitors2007

    • Author(s)
      Fuwa H^*, Konno Y, Takahashi Y, Sasaki M, Yokoshima S, Kan T, Fukuyama T, Natsugari H, Tomita T^*, Iwatsubo T
    • Journal Title

      ACS Chem Biol 2

      Pages: 408-418

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Journal Article] The Tottori (D7N) and English (H6R) familial Alzheimer's disease mutations accelerate All fibril formation without increasing protofibril formation2007

    • Author(s)
      Hori Y, Hashimoto T, Wakutani Y, Urakami K, Nakashima K, Condron MM, Tsubuki S, Saido TC, Teplow DB, Iwatsubo T
    • Journal Title

      J Biol Chem 282

      Pages: 4916-4923

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Journal Article] Convenient synthesis of photoaffinity probes and evaluation of their cross-linking abilities2007

    • Author(s)
      Kan T^*, Kita Y, Morohashi Y, Tominari Y, Hosoda S, Tomita T, Natsugari H, Iwatsubo T, Fukuyama T
    • Journal Title

      Org lett 9

      Pages: 2055-2058

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Journal Article] The intracellular domain of the amyloid precursor protein (AICD) enhances the p53-mediated apoptosis2006

    • Author(s)
      Ozaki T, Li Y, Kikuchi H, Tomita T, Iwatsubo T, Nakagawara A^*
    • Journal Title

      Biochem Biophys Res Comm 351

      Pages: 57-63

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Journal Article] Novel γ-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates2006

    • Author(s)
      Takahashi Y, Fuwa H, Kaneko A, Sasaki M, Yokoshima S, Koizumi H, Takebe T, Kan T, Iwatsubo T^*, Tomita T, Natsugari H^*, Fukuyama T
    • Journal Title

      Bioorg Med Chem Lett 16

      Pages: 3813-3816

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Journal Article] Major involvement of low-density lipoprotein receptor-related protein 1 in the clearance of plasma free amyloid β-peptide by the liver2006

    • Author(s)
      Tamaki C, Ohtsuki S, Iwatsubo T, Hashimoto T, Yamada K, Yabuki C, Terasaki T
    • Journal Title

      Pharmaceut Res 23

      Pages: 1407-1416

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Journal Article] Familial Parkinson mutantα-synuclein causes dopamine neuron dysfunction in transgenic C. elegans.2006

    • Author(s)
      Kuwahara, T., Koyama, A., Gengyo-Ando, K., Masuda, M., Kowa, H., Tsunoda, M., Mitani, S., Iwatsubo, T.
    • Journal Title

      J. Biol. Chem. 281

      Pages: 334-340

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17025009
  • [Journal Article] Presenilin-dependent intramembrane cleavage of ephrin-B12006

    • Author(s)
      Tomita T^*, Tanaka S, Morohashi Y, Iwatsubo T^*
    • Journal Title

      Molecular Neurodegeneration 1

      Pages: 2-2

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Journal Article] Synthesis of biotinylated photoaffinity probes based on arylsulfonamide γ-secretase inhibitors2006

    • Author(s)
      Fuwa H, Hiromoto K, Takahashi Y, Yokoshima S, Kan T, Fukuyama T, Iwatsubo T, Tomita T, Natsugari H^*
    • Journal Title

      Bioorg Med Chem Lett 16

      Pages: 4184-4189

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Journal Article] Naphthyl and coumarinyl biarylpiperazine derivatives as highly potent human β-secretase inhibitors. Design, synthesis, enzymatic BACE-1 and cell assays2006

    • Author(s)
      Garino C, Tomita T, Pietrancosta N, Laras Y, Rosas R, Herbette G, Maigret B, Quelever G, Iwatsubo T, Kraus J. -L^*
    • Journal Title

      J Med Chem 49

      Pages: 4275-4285

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Journal Article] Structure of the catalytic pore of γ-secretase probed by the accessibility of substituted cysteines2006

    • Author(s)
      Sato C, Morohashi Y, Tomita T^*, Iwatsubo T^*
    • Journal Title

      J Neurosci 26

      Pages: 12081-12088

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Journal Article] Three-dimensional structure of the γ-secretase complex2006

    • Author(s)
      Ogura T, Mio K, Hayashi I, Miyashita H, Fukuda R, Kopan R, Kodama T, Hamakubo T, Iwatsubo T, Tomita T^*, Sato C^*
    • Journal Title

      Biochem Biophys Res Comm 343

      Pages: 525-534

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Journal Article] Concise and short synthesis of functionalized 5, 6-Dihydropyridin-2-ones by means of palladium (0)-catalyzed cross-coupling of ketene aminal phosphates2006

    • Author(s)
      Fuwa H, Kaneko A, Sugimoto Y, Tomita T, Iwatsubo T, Sasaki M^*
    • Journal Title

      Heterocycles 70

      Pages: 101-106

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Journal Article] C-terminal fragment of Presenilin is the molecular target of a dipeptidic γ-secretase-specific Inhibitor DAPT2006

    • Author(s)
      Morohashi Y, Kan T, Tominari Y, Fuwa H, Okamura Y, Watanabe N, Sato C, Natsugari H, Fukuyama T, Iwatsubo T^*, Tomita T^*
    • Journal Title

      J Biol Chem 281

      Pages: 14670-14676

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Journal Article] Aph-1 contributes to the stabilization and trafficking of the γ-secretase complex through mechanisms involving inter-and intramolecular interactions2005

    • Author(s)
      Niimura M, Isoo N, Takasugi N, Tsuruoka M, Ui-Tei K, Saigo K, Morohashi Y, Tomita T^*, Iwatsubo T^*
    • Journal Title

      J Biol Chem 280

      Pages: 12967-12975

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Journal Article] Pen-2 is incorporated into the γ-secretase complex through binding to transmembrane domain 4 of presenilin 12005

    • Author(s)
      Watanabe N, Tomita T^*, Sato C, Kitamura T, Morohashi Y, Iwatsubo T^*
    • Journal Title

      J Biol Chem 280

      Pages: 41967-41975

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Journal Article] Association of active γ-secretase complex with lipid rafts2005

    • Author(s)
      Drano Y, Hayashi I, Isoo N, Reid PC, Shibasaki Y, Noguchi N, Tomita T, Iwatsubo T, Hamakubo T^*, Kodama T
    • Journal Title

      J Lipid Res 46

      Pages: 904-912

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Journal Article] CLAC binds to amyloid β peptides through the positively-charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils2005

    • Author(s)
      Osada Y, Hashimoto T, Nishimura A, Matsuo Y Wakabayashi T, Iwatsubo T.
    • Journal Title

      J Biol Chem 280

      Pages: 8596-8605

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Journal Article] Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling2005

    • Author(s)
      Takeda T, Asahi M, Yamaguchi O, Hikoso S, Nakavama H, Kusakari Y, Kawai M, Hongo K, Higuchi Y, Kashiwase K, Watanabe T, Taniike M, Nakai A, Nishida K, Kurihara S, Donoviel DB, Bernstein A, Tomita T, Iwatsubo T, Hori M, Otsu K^*
    • Journal Title

      FASEB J. 19

      Pages: 2069-2071

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Presentation] Aquaporin4 がタウ蓄積と神経変性に果たす役割2021

    • Author(s)
      山田 薫、石田 和久、橋本 唯史、阿部 陽一郎、安井 正人、岩坪 威
    • Organizer
      第40回 日本認知症学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H00525
  • [Presentation] Involvement of LRRK2 in the lysosomal and exosomal release2021

    • Author(s)
      Maria Sakurai, Tomoki Kuwahara, Tomoya Eguchi, Takeshi Iwatsubo
    • Organizer
      AD/PD 2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H00525
  • [Presentation] Analysis of Rab29 phosphorylation under lysosomal overload stress2021

    • Author(s)
      Tomoki Kuwahara, Tadayuki Komori, Kai Funakawa, Maria Sakurai, Takeshi Iwatsubo
    • Organizer
      AD/PD 2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H00525
  • [Presentation] アルツハイマー病の予防・治療薬開発に向けて:研究の現況と社会・学術連携2020

    • Author(s)
      岩坪威
    • Organizer
      日本学術会議 学術フォーラム「認知症―予防と共生に向けて学術の取り組み」
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04193
  • [Presentation] Aquaporin-4 deficiency exacerbates tau accumulation and neurodegeneration in a mouse model of tauopathies.2020

    • Author(s)
      Yamada K, Ishida K, Hashimoto T, Abe Y, Yasui M, Iwatsubo T
    • Organizer
      第 43回日本神経科学大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H00525
  • [Presentation] アルツハイマー病の超早期治療と予防2019

    • Author(s)
      岩坪威
    • Organizer
      第30回日本医学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04193
  • [Presentation] Soluble high-molecular weight oligomers of amyloid-beta peptide derived from the brains of APP transgenic mice induce cerebral amyloid-beta deposits2019

    • Author(s)
      Tadafumi Hashimoto, Yasushi Naka, Kashiwagi-Hakozaki Mayu, Tomoya Tajiri, Takeshi Iwatsubo
    • Organizer
      Neuroscience2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04193
  • [Presentation] アルツハイマー病基礎研究の進歩2019

    • Author(s)
      岩坪威
    • Organizer
      第38回日本認知症学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04193
  • [Presentation] アミロイド斑蓄積のseedとして働く可溶性Abetaオリゴマーの同定2018

    • Author(s)
      箱崎眞結、仲泰史、田尻智也、深山正久、橋本唯史、岩坪威
    • Organizer
      第37回日本認知症学会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04193
  • [Presentation] Characterization of the seed Abeta oligomers in the brains of APP transgenic mice2018

    • Author(s)
      Mayu Hakozaki-Kashiwagi, Yasushi Naka, Tomohiko Tajiri, Masashi Fukayama, Tadafumi Hashimoto, Takeshi Iwatsubo
    • Organizer
      19th International Congress of Neuropathology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04193
  • [Presentation] ヒト型とマウス型apolipoprotein EがAbeta脳内dynamicsに与える影響の相違2018

    • Author(s)
      粉川明日香、大野裕太郎、橋本唯史、岩坪威
    • Organizer
      第37回日本認知症学会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04193
  • [Presentation] アルツハイマー病:超早期の治療に向けて2018

    • Author(s)
      岩坪威
    • Organizer
      第52回日本成人病(生活習慣病)学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K15478
  • [Presentation] Characterization of the high molecular weight Abeta oligomers derived from the brains of APP transgenic mice2017

    • Author(s)
      Tadafumi Hashimoto, Yasushi Naka, Tomoya Tajiri, Mayu Hakozaki-Kashiwagi, Takeshi Iwatsubo
    • Organizer
      Neuroscience2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04193
  • [Presentation] アルツハイマー病:超早期の治療に向けて2017

    • Author(s)
      岩坪 威
    • Organizer
      第52回日本成人病(生活習慣病)学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04193
  • [Presentation] Alzheimer's disease:from molecular pathology to prevention2017

    • Author(s)
      Takeshi Iwatsubo
    • Organizer
      4th Federation of Asian-Oceanian neuroscience societies syposium
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04193
  • [Presentation] Differential effects of human and mouse apolipoprotein E on the metabolism and aggregation of amyloid-beta peptides2017

    • Author(s)
      Asuka Kokawa, Yutaro Ohno, Tadafumi Hashimoto, Takeshi Iwatsubo
    • Organizer
      Neuroscience2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04193
  • [Presentation] Alzheimer’s disease: from molecular pathology to prevention.2017

    • Author(s)
      Takeshi Iwatsubo
    • Organizer
      4th Federation of Asian-Oceanian neuroscience societies symposium.
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K15478
  • [Presentation] Effects of diet-induced obesity and diet control on insulin response and amyloid pathology in the brains of Alzheimer model mice.2016

    • Author(s)
      Wakabayashi T, Yamaguchi K, Matsui K, Hashimoto T, Kubota T, Kubota N, Kadowaki T, Iwatsubo T
    • Organizer
      Neurobiology of Brain Disorders, Gordon Research Conference
    • Place of Presentation
      Girona (Spain)
    • Year and Date
      2016-08-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K15478
  • [Presentation] Molecular pathology and translational approaches on Alzheimer’s disease.2015

    • Author(s)
      Iwatsubo T
    • Organizer
      The 12th International conference on Alzheimer’s & Parkinson’s diseases.
    • Place of Presentation
      Nice, France
    • Year and Date
      2015-03-19
    • Invited
    • Data Source
      KAKENHI-PLANNED-22110003
  • [Presentation] オプとジェネティックスを用いた神経活動依存的なAβ分泌・蓄積の検討2012

    • Author(s)
      山本薫、奥野浩行、尾藤晴彦、若林朋子、橋本唯史、岩坪威
    • Organizer
      第31回 日本認知症学会
    • Place of Presentation
      筑波市
    • Invited
    • Data Source
      KAKENHI-PLANNED-22110003
  • [Presentation] Molecular pathology and disease-modifying therapy for Alzheimer's disease2011

    • Author(s)
      Iwatsubo T
    • Organizer
      The 52^<nd> annual meeting of the Japanese Neuro pathological Society
    • Place of Presentation
      名古屋国際会議場(愛知県)(招待講演)
    • Year and Date
      2011-05-18
    • Data Source
      KAKENHI-PLANNED-22110003
  • [Presentation] Alzheimer's disease : from cellular to synapse/circuit biology.2010

    • Author(s)
      Iwatsubo T
    • Organizer
      Kick off symposium of Scientific Research on Innovative Area "Foundation of Synapse and Neurocircuit Pathology".
    • Place of Presentation
      Tokyo(東京医科歯科大学講堂)
    • Year and Date
      2010-10-27
    • Data Source
      KAKENHI-PLANNED-22110003
  • [Presentation] パーキンソン病の分子病態―αシヌクレインとLRRK2をめぐって2009

    • Author(s)
      岩坪威
    • Organizer
      第7回パーキンソン病懇話会
    • Place of Presentation
      アークホテル岡山(岡山県)
    • Year and Date
      2009-11-05
    • Data Source
      KAKENHI-PROJECT-17025009
  • [Presentation] アルツハイマー病に対するJ-ADNI projectとバイオマーカー2008

    • Author(s)
      岩坪 威
    • Organizer
      第9回創薬ビジョンシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2008-01-25
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Presentation] Structure and function of γ-secretase2008

    • Author(s)
      Iwatsubo T
    • Organizer
      Keystone symposia
    • Place of Presentation
      Keystone
    • Year and Date
      2008-03-26
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Presentation] Structure and function of γ-secretase2008

    • Author(s)
      Iwatsubo T.
    • Organizer
      Keystone symposia, Alzheimer's disease
    • Place of Presentation
      Keystone
    • Year and Date
      2008-05-26
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Presentation] Alzheimer's disease: β-amyloid and γ-secretase.2008

    • Author(s)
      Iwatsubo T
    • Organizer
      10th International Hong Kong/Springfield Symposium on Advances in Alzheimer Therapy
    • Place of Presentation
      Hong-Kong
    • Year and Date
      2008-03-01
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Presentation] Normal and pathological function of LRRK22008

    • Author(s)
      Iwatsubo T
    • Organizer
      12th International Congress of Parkinson's Disease and Movement Disorders
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2008-06-26
    • Data Source
      KAKENHI-PROJECT-17025009
  • [Presentation] Alzheimer's disease : β-amyloid and γ-secretase2008

    • Author(s)
      Iwatsubo T
    • Organizer
      10th International Hong Kong/Springfield Symposium on Advances in Alzheimer Therapy
    • Place of Presentation
      Hong-Kong
    • Year and Date
      2008-03-01
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Presentation] Alzheimer's disease:β-amyloid and γ-secretase2008

    • Author(s)
      Iwatsubo T.
    • Organizer
      10th Intemational Hong Kong/Springfield Symposium on Advances in Alzheimer Therapy
    • Place of Presentation
      Hong-Kong
    • Year and Date
      2008-05-01
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Presentation] Molecular pathology of Alzheimer's disease: focusing on Aβ and γ-secretase.2007

    • Author(s)
      Iwatsubo T
    • Organizer
      Workshop on Alzheimer's disease and Parkinson's disease. RIKEN BSI
    • Place of Presentation
      Wako
    • Year and Date
      2007-03-15
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Presentation] アルツハイマー病のdisease-modifing therapy:分子病態から臨床へ2007

    • Author(s)
      岩坪 威
    • Organizer
      第7回静岡ディメンシア懇話会
    • Place of Presentation
      浜松
    • Year and Date
      2007-11-17
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Presentation] Role of α-synuclein aggregation in Parkinson' s disease.2007

    • Author(s)
      Iwatsubo T
    • Organizer
      第5回パーキンソン病シンポジウム高松
    • Place of Presentation
      高松
    • Year and Date
      2007-04-12
    • Data Source
      KAKENHI-PROJECT-17025009
  • [Presentation] パーキンソン病の分子病態:α-synucleinとLRRK2をめぐって2007

    • Author(s)
      Iwatsubo T
    • Organizer
      第12回東海パーキンソン病研究会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-09-28
    • Data Source
      KAKENHI-PROJECT-17025009
  • [Presentation] Molecular pathology of Alzheimer's disease : from benchside to clinics2007

    • Author(s)
      Iwatsubo T
    • Organizer
      The 4th retreat of 21st century COE on brain medicine of the University of Tokyo
    • Place of Presentation
      Hakone
    • Year and Date
      2007-07-13
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Presentation] アルツハイマー病の分子病理学2007

    • Author(s)
      岩坪 威
    • Organizer
      第48回日本神経病理学会総会学術研究会ランチョンセミナー
    • Place of Presentation
      東京
    • Year and Date
      2007-06-01
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Presentation] アルツハイマー病:基礎研究から根本治療へ2007

    • Author(s)
      岩坪 威
    • Organizer
      北海道大学大学院薬学研究院神経病理・病態生・化学(IBL)分野寄付講座開設記念シンポジウム「アルツハイマー病研究の100年と治療法・治療薬開発への道のり」
    • Place of Presentation
      札幌
    • Year and Date
      2007-05-24
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Presentation] DLBの分子遺伝2007

    • Author(s)
      Iwatsubo T
    • Organizer
      第1回DLB研究会
    • Place of Presentation
      横浜
    • Year and Date
      2007-11-10
    • Data Source
      KAKENHI-PROJECT-17025009
  • [Presentation] Molecular pathology of Alzheimer's disease2007

    • Author(s)
      Iwatsubo T.
    • Organizer
      β-amyloid and γ-secretase. Japan-Korea Neurosci ence Symposium "Cutting Edge of Neuroscience"
    • Place of Presentation
      Yokohama
    • Year and Date
      2007-09-13
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Presentation] Molecular pathology of Alzheimer's disease: β-amyloid and γ-secretase.2007

    • Author(s)
      Iwatsubo T
    • Organizer
      Japan-Korea Neuroscience Symposium
    • Place of Presentation
      Yokohama
    • Year and Date
      2007-09-13
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Presentation] Molecular pathology of Alzheimer's disease : β-amyloid and γ-secretase2007

    • Author(s)
      Iwatsubo T
    • Organizer
      Japan-Korea Neuroscience Symposium
    • Place of Presentation
      Yokohama
    • Year and Date
      2007-09-13
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Presentation] Molecular pathology of Alzheimer's disease : focusing on Aβ and γ-secretase2007

    • Author(s)
      Iwatsubo T
    • Organizer
      Workshop on Alzheimer's disease and Parkinson's disease. RIKEN BSI
    • Place of Presentation
      Wako
    • Year and Date
      2007-03-15
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Presentation] アルツハイマー病の分子病理学2007

    • Author(s)
      岩坪 威
    • Organizer
      Neuro 2007
    • Place of Presentation
      横浜
    • Year and Date
      2007-09-10
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Presentation] パーキンソン病の分子病態: α-synucleinとLRRK2をめぐって2007

    • Author(s)
      Iwatsubo T
    • Organizer
      第13回北海道パーキンソン病研究会
    • Place of Presentation
      札幌
    • Year and Date
      2007-06-23
    • Data Source
      KAKENHI-PROJECT-17025009
  • [Presentation] Molecular pathology of Alzheimer's disease: from benchside to clinics.2007

    • Author(s)
      Iwatsubo T
    • Organizer
      The 4th retreat of 21st century COE on brain medicine of the University of Tokyo
    • Place of Presentation
      Hakone
    • Year and Date
      2007-07-13
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Presentation] Molecular pathology of Alzheimer's disease2007

    • Author(s)
      Iwatsubo T.
    • Organizer
      from benchside to clinics. The 4^〈th〉retreat of 21^〈st〉century COE on brain medicine of the University of Tokyo
    • Place of Presentation
      Hakone
    • Year and Date
      2007-07-03
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Presentation] γセクレターゼ・プレセニリンを標的とした治療戦略2007

    • Author(s)
      岩坪 威
    • Organizer
      第27回日本医学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2007-04-07
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Presentation] Challenges for the enigma of Aβ and γ-secretase2006

    • Author(s)
      Iwatsubo T
    • Organizer
      Alzheimer 100 years and beyond
    • Place of Presentation
      Tuebingen
    • Year and Date
      2006-11-04
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Presentation] Molecular pathology of Alzheimer's disease: β -amyloid and γ-secretase.2006

    • Author(s)
      Iwatsubo T
    • Organizer
      Wellcome Trust/CSHL Course Molecular Neurology and Neuropathology Lecture
    • Place of Presentation
      Cambridge
    • Year and Date
      2006-07-22
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Presentation] γ-Secretase: Structure and Function.2006

    • Author(s)
      Iwatsubo T
    • Organizer
      Ringberg symposium on regulated membrane proteolysis
    • Place of Presentation
      Ringberg
    • Year and Date
      2006-11-29
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Presentation] Molecular pathology of Alzheimer's disease : β-amyloid and γ-secretase2006

    • Author(s)
      Iwatsubo T
    • Organizer
      Wellcome Trust/ CSHL Course Molecular Neurology and Neuropathology Lecture
    • Place of Presentation
      Cambridge
    • Year and Date
      2006-07-02
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Presentation] g-Secretase2006

    • Author(s)
      Iwatsubo T
    • Organizer
      Alzforum Tenth Anniversary Symposium 10th International Meeting on Alzheimer's Disease and Related Disorders
    • Place of Presentation
      Madrid
    • Year and Date
      2006-07-17
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Presentation] Challenges for the enigma of Aβ and γ-secretase.2006

    • Author(s)
      Iwatsubo T
    • Organizer
      Alzheimer 100 years and beyond
    • Place of Presentation
      Tuebingen
    • Year and Date
      2006-11-04
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Presentation] Alzheimer's disease : β-amyloid and γ-secretase as therapeutic targets2006

    • Author(s)
      Iwatsubo T
    • Organizer
      The 4th COE international symposium
    • Place of Presentation
      Tokyo
    • Year and Date
      2006-11-14
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Presentation] Structure and Function of presenilin. Demonstration of a water-accessible pore within γ-secretase by SCAM analysis2006

    • Author(s)
      Iwatsubo T
    • Organizer
      10th International Meeting on Alzheimer's Disease and Related Disorders
    • Place of Presentation
      Madrid
    • Year and Date
      2006-07-17
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Presentation] γ-Secretase.2006

    • Author(s)
      Iwatsubo T
    • Organizer
      Alzforum Tenth Anniversary Symposium. 10th International Meeting on Alzheimer's Disease and Related Disorders
    • Place of Presentation
      Madrid
    • Year and Date
      2006-07-19
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Presentation] γ-Secretase : Structure and Function2006

    • Author(s)
      Iwatsubo T
    • Organizer
      Ringberg symposium on regulated membrane Proteolysis
    • Place of Presentation
      Ringberg
    • Year and Date
      2006-11-29
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Presentation] Alzheimer's disease: β-amyloid and γ-secretase as therapeutic targets.2006

    • Author(s)
      Iwatsubo T
    • Organizer
      The 4th COE international symposium
    • Place of Presentation
      Tokyo
    • Year and Date
      2006-11-14
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Presentation] Molecular Pathology of Alzheimer's disease : β-amyloid and γ-secretase2005

    • Author(s)
      Iwatsubo T
    • Organizer
      The 3rd Takeda Science Foundation Symposium on PharmaSciences : On the Frontiers of Neuro-PharmaScie-Molecular Pathology and DrugAction
    • Place of Presentation
      Tokyo
    • Year and Date
      2005-12-05
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Presentation] Structure and Function of presenilin. Demonstration of a water-accessible pore within γ-secretase by SCAM analysis.2005

    • Author(s)
      Iwatsubo T
    • Organizer
      The 3rd Takeda Science Foundation Symposium on PharmaSciences: On the Frontiers of Neuro-PharmaSciences-Molecular Pathology and Drug Action
    • Place of Presentation
      Tokyo
    • Year and Date
      2005-12-05
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17200025
  • [Presentation] Structure and function of γ-secretase.

    • Author(s)
      Iwatsubo T
    • Organizer
      Keystone symposia, Alzheimer's disease
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17200025
  • 1.  TOMITA Taisuke (30292957)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 2 results
  • 2.  HASEGAWA Nmasato (10251232)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 3.  NUKINA Nobuyuki (10134595)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 4.  HASHIMOTO Tadafumi (30334337)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 20 results
  • 5.  SOFUE Gen (20148315)
    # of Collaborated Projects: 3 results
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  • 6.  IHARA Yasuo (60114386)
    # of Collaborated Projects: 3 results
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  • 7.  NISHIKAWA Toru (00198441)
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    # of Collaborated Products: 0 results
  • 8.  WAKABAYASHI Tomoko (20530330)
    # of Collaborated Projects: 3 results
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  • 9.  SAITO Yuuko (60344066)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 10.  MURAYAMA Shigeo (50183653)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 11.  OKAZAWA Hitoshi (50261996)
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    # of Collaborated Products: 4 results
  • 12.  山田 薫 (00735152)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 5 results
  • 13.  KUZUHARA Shigeki (70111383)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  KOKUBO Yasumasa (60263000)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  SASAKI Ryogen (60303723)
    # of Collaborated Projects: 1 results
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  • 16.  KUWANO Ryouzou (20111734)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 17.  TOMIYAMA Hiroyuki (20515069)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  HATTORI Nobutaka (80218510)
    # of Collaborated Projects: 1 results
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  • 19.  TSUJI Syouji (70150612)
    # of Collaborated Projects: 1 results
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  • 20.  HARA Kenjyu (10377195)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  ITO Genta (10431892)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 22.  YAMAZAKI Tsuneo (80200658)
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  • 23.  MORISHIMA Maho (50204722)
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  • 24.  YANAGISAWA Katsuhiko (10230260)
    # of Collaborated Projects: 1 results
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  • 25.  IMAI Kazuhiro (50012620)
    # of Collaborated Projects: 1 results
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  • 26.  ESAKI Nobuyosi (50135597)
    # of Collaborated Projects: 1 results
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  • 27.  ASANO Yasuhisa (00222589)
    # of Collaborated Projects: 1 results
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  • 28.  TOYOOKA Tosimasa (40183496)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  NAGATA Yoko (00164442)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  MISONO Haruo (30027073)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 1 results
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  • 34.  Nakamura Katsuki (70243110)
    # of Collaborated Projects: 1 results
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  • 35.  Ohtsuka Toshihisa (40401806)
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  • 36.  Aoki Shigeki (80222470)
    # of Collaborated Projects: 1 results
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  • 176.  吉田 知之
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  • 178.  鈴木 一詩
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  • 179.  西山 義剛
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  • 180.  間野 達雄
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  • 181.  田川 一彦
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