Hashimoto Tadafumi 橋本唯史

… Alternative Names

Researcher Number	30334337
Other IDs
Affiliation (Current)	2019: 東京大学, 大学院医学系研究科(医学部), 特任准教授
Affiliation (based on the past Project Information) *help	2016 – 2019: 東京大学, 大学院医学系研究科(医学部), 特任准教授 2017: 東京大学, 医学(系)研究科(研究院), 助教 2017: 東京大学, 医学(系)研究科(研究院), 特任准教授 2015: 東京大学, 医学(系)研究科(研究院), 講師 2014: 東京大学, 医学(系)研究科(研究院), 助教 … More
Review Section/Research Field	Principal Investigator Biological pharmacy / Nerve anatomy/Neuropathology / Pathological medical chemistry / Biological Sciences / Basic Section 51030:Pathophysiologic neuroscience-related Except Principal Investigator Biological Sciences / Neurochemistry/Neuropharmacology / Biological pharmacy / Neurology
Keywords	Principal Investigator CLAC / アルツハイマー病 / アミロイドβ蛋白質 / 筋萎縮性側索硬化症 / 前頭側頭葉変性症 / 神経変性疾患 / アミロイドβペプチド / コラーゲン / 老人斑 / 神経科学 … More Except Principal Investigator アルツハイマー病 / Aβ / アミロイド / アルツハイマー / βアミロイド / アミロイドβペプチド / シナプス / 光遺伝学 / 神経活動 / マイクロダイアリシス / γセクレターゼ / 結合タンパク / Alzheimer's disease / γ-Secretase / Amyloid / amyloid binding protein / リピッドフリッパーゼ / アミロイドβ / amyloid beta peptide / tau / タウ / 脳神経疾患 Less

Elucidation of physiological and pathological roles of TDP-43 through autophagic machineryPrincipal InvestigatorOngoing
- Principal Investigator
  
  橋本唯史
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  The University of Tokyo
アルツハイマー病発症機構における脂質フリッパーゼの役割の解析と予防・治療法の開発Ongoing
- Principal Investigator
  
  高杉展正
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Okayama University
ALS病因タンパク質FUSの細胞間伝播及び神経細胞障害性発揮メカニズムの解明Principal Investigator
- Principal Investigator
  
  橋本唯史
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
アルツハイマー病Aβの脳内エコノミー破綻によるタウ依存的神経障害の分子基盤解明Ongoing
- Principal Investigator
  
  岩坪威
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  The University of Tokyo
Elucidation of the pathomechanism of neurodegeneration induced by TDP-43Principal Investigator
- Principal Investigator
  
  Hashimoto Tadafumi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokyo
Study for the metabolism and neurotoxicity of amyloid beta peptide oligomersPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Tadafumi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Research Activity start-up
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  The University of Tokyo
Elucidation of the molecular pathology of Alzheimer's disease focusing on the synapses toward therapies
- Principal Investigator
  
  IWATSUBO Takeshi
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
アルツハイマー病脳におけるアミロイド構成蛋白質CLACに関する研究Principal Investigator
- Principal Investigator
  
  橋本唯史
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
アルツハイマー病新規アミロイド構成蛋白質CLACに関する病態生化学的研究Principal Investigator
- Principal Investigator
  
  橋本唯史
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
Molecular and cell biological studies on the production, aggregation and clearance of Alzheimer amyloid β peptides.
- Principal Investigator
  
  IWATSYBO Takeshi
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  The University of Tokyo
アルツハイマー病脳老人斑アミロイドを構成する新規タンパク質CLACに関する研究Principal Investigator
- Principal Investigator
  
  橋本唯史
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo

All 2019 2018 2017 2016 2015 2014 2013 2012 2007 2006 2005 Other

All Journal Article Presentation

[Journal Article] Chronic cerebral hypoperfusion shifts the equilibrium of amyloid β oligomers to aggregation-prone species with higher molecular weight2019
- Author(s)
  Bannai Taro、Mano Tatsuo、Chen Xigui、Ohtomo Gaku、Ohtomo Ryo、Tsuchida Takeyuki、Koshi-Mano Kagari、Hashimoto Tadafumi、Okazawa Hitoshi、Iwatsubo Takeshi、Tsuji Shoji、Toda Tatsushi、Iwata Atsushi
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Pages: 1-11
- DOI
  10.1038/s41598-019-39494-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07364, KAKENHI-PUBLICLY-17H05687, KAKENHI-PROJECT-16H05319, KAKENHI-PROJECT-17H04193, KAKENHI-PROJECT-17K16113
[Journal Article] Self-assembly of FUS through its low-complexity domain contributes to neurodegeneration2018
- Author(s)
  Taisei Matsumoto, Koji Matsukawa, Naruaki Watanabe, Yuya Kishino, Hayato Kunugi, Ryoko Ihara, Tomoko Wakabayashi, Tadafumi Hashimoto, Takeshi Iwatsubo
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 印刷中 Pages: 1353-1365
- DOI
  10.1093/hmg/ddy046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08297, KAKENHI-PROJECT-18K07364, KAKENHI-PUBLICLY-17H05687
[Journal Article] Patterns and severity of vascular amyloid in Alzheimer’s disease associated with duplications and missense mutations in APP gene, Down syndrome and sporadic Alzheimer’s disease2018
- Author(s)
  Mann David M. A.、Davidson Yvonne S.、Robinson Andrew C.、Allen Nancy、Hashimoto Tadafumi、Richardson Anna、Jones Matthew、Snowden Julie S.、Pendleton Neil、Potier Marie-Claude、Laquerri?re Annie、Prasher Vee、Iwatsubo Takeshi、Strydom Andre
- Journal Title
  
  Acta Neuropathologica
  
  Volume: 136 Pages: 569-587
- DOI
  10.1007/s00401-018-1866-3
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07364, KAKENHI-PUBLICLY-17H05687, KAKENHI-PROJECT-17H04193
[Journal Article] TMEM30A is a candidate interacting partner for the β-carboxyl-terminal fragment of amyloid-β precursor protein in endosomes2018
- Author(s)
  Takasugi Nobumasa、Araya Runa、Kamikubo Yuji、Kaneshiro Nanaka、Imaoka Ryosuke、Jin Hao、Kashiyama Taku、Hashimoto Yoshie、Kurosawa Masaru、Uehara Takashi、Nukina Nobuyuki、Sakurai Takashi
- Journal Title
  
  PLOS ONE
  
  Volume: 13 Pages: 0200988-0200988
- DOI
  10.1371/journal.pone.0200988
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08272, KAKENHI-PROJECT-17K09040, KAKENHI-PROJECT-17H01564, KAKENHI-PROJECT-16H04667
[Journal Article] Soluble oligomeric amyloid-beta induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain2017
- Author(s)
  Michal Arbel-Ornath, Eloise Hudry, Josiah R Bovine, Tadafumi Hashimoto, Shuko Takeda, Kishore V Kuchbhotla, Steven Hou, Carli R Lattarulo, Arianna M Belcher, Naomi Shakerdge, et al
- Journal Title
  
  Molecular Neurodegeneration
  
  Volume: 12 Pages: 27-27
- DOI
  10.1186/s13024-017-0169-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05687, KAKENHI-PROJECT-15K08297
[Journal Article] Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer's disease.2017
- Author(s)
  Mano T, Nagata K, Nonaka T, Tarutani A, Koshi-Mano K, Tsuchida T, Ohtomo R, Takahashi-Fujigasaki J, Yamashita S, Ohyagi Y, Yamazaki R, Tsuji S, Tamaoka A, Ikeuchi T, Saido CT, Iwatsubo T, Ushijima T, Murayama S, Hasegawa M, Iwata A, et al.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 114 Issue: 45
- DOI
  10.1073/pnas.1707151114
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09664, KAKENHI-PROJECT-17K16113, KAKENHI-PUBLICLY-17H05687, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356, KAKENHI-PROJECT-16H05319, KAKENHI-PROJECT-15K08297, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-16H06297
[Journal Article] Familial ALS-linked mutations in Profilin 1 exacerbated TDP-43 induced degeneration in the retina of Drosophila Melanogaster through an increase in the cytoplasmic localization of TDP-43.2016
- Author(s)
  Matsukawa K, Hashimoto T, Matsumoto T, Ihara R, Chihara T, Miura M, Wakabayashi T, Iwatsubo T.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 291 Pages: 23464-23476
- DOI
  10.1074/jbc.m116.729152
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04375, KAKENHI-PROJECT-14J06189, KAKENHI-PROJECT-15K08297
[Journal Article] Calcium-responsive transactivator (CREST) protein shares a set of structural and functional traits with other proteins associated with amyotrophic lateral sclerosis.2015
- Author(s)
  Michail S. Kukharsky, Annamaria Quintiero, Taisei Matsumoto, Koji Matsukawa, Haiyan An, Tadafumi Hashimoto, Takeshi Iwatsubo, Vladimir L. Buchman, Tatyana A. Shelkovnikova
- Journal Title
  
  Molecular Neurodegeneration
  
  Volume: 10
- DOI
  10.1186/s13024-015-0014-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08297, KAKENHI-PROJECT-14J06189
[Journal Article] Chronic optogenetic activation augments abeta pathology in a mouse model of Alzheimer disease.2015
- Author(s)
  Kaoru Yamamoto, Zen-ichi Tanei, Tadafumi Hashimoto, Tomoko Wakabayashi, Hiroyuki Okuno, Yasushi Naka, Ofer Yizhar, Lief E. Fenno, Masashi Fukayama, Haruhiko Bito, John R. Cirrito, David M. Holtzman, Karl Deisseroth, Takeshi Iwatsubo
- Journal Title
  
  Cell Rep
  
  Volume: 11 Pages: 859-865
- DOI
  10.1016/j.celrep.2015.04.017
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-22110003, KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-15K08297, KAKENHI-PROJECT-15H02358
[Journal Article] Role of Apolipoprotein E in β-Amyloidogenesis: Isoform-specific effects on protofibril to fibril conversion of Aβ in vitro and brain Aβ deposition in vivo.2015
- Author(s)
  Yukiko Hori, Tadafumi Hashimoto, Hidetoshi Nomoto, Bradley T Hyman, Takeshi Iwatsubo
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 290 Pages: 15163-15174
- DOI
  10.1074/jbc.m114.622209
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08297, KAKENHI-PROJECT-26893042
[Journal Article] RNA aptamer probes as optical imaging agents for the detection of amyloid plaques2014
- Author(s)
  Christian T Farrar, Christopher M William, Eloise Hudry, Tadafumi Hashimoto, and Hyman BT
- Journal Title
  
  PLoS One
  
  Volume: 9(2)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24800015
[Journal Article] CLAC-P/collagen type XXV is required for the intramuscular innervation of motoneurons during neuromuscular development2014
- Author(s)
  Tanaka T, Wakabayashi T, Oizumi H, Nishio S, Sato T, Harada A, Fujii D, Matsuo Y, Hashimoto T, Iwatsubo T.
- Journal Title
  
  j. Neurosci.
  
  Volume: 34 Pages: 1370-1379
- DOI
  10.1523/jneurosci.2440-13.2014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591347, KAKENHI-PROJECT-24390046, KAKENHI-PROJECT-24659084, KAKENHI-PROJECT-24700373, KAKENHI-PROJECT-24800015, KAKENHI-PUBLICLY-25113517
[Journal Article] CLAC-P/collagen type XXV is required for the intramuscular innervation of motoneurns during neuromuscular development2014
- Author(s)
  Tomohiro Tanaka, Tomoko Wakabayashi, Hiroaki Oizumi, Shu Nishio, Takashi Sato, Akihiro Harada, Daisuke Fujii, Yuko Matsuo, Tadafumi Hashimoto, and Takeshi Iwatsubo
- Journal Title
  
  J. Neurosci.
  
  Volume: 34(4) Pages: 1370-1379
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24800015
[Journal Article] Microfluidic chemotaxis platform for differentiating the roles of soluble and bound amyloid-beta on microglia accumulation2013
- Author(s)
  Hansang Cho, Tadafumi Hashimoto, Elisabeth Wong, Yukiko Hori, Levi B Wood, Lingzhi Zhao, Kevin M Daigis, Bradley T Hyman, and Daniel Irimia
- Journal Title
  
  Sci. Rep.
  
  Volume: 3 Pages: 1823-1823
- DOI
  10.1038/srep01823
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24800015
[Journal Article] RNA binding mediates neurotoxicity in the transgenic Drosophila model of TDP-43 proteinopathy2013
- Author(s)
  Ihara R, Matsukawa K, Nagata Y, Kunugi H, Tsuji S, Chihara T, Kuranaga E, Miura M, Wakabayashi T, Hashimoto T, Iwatsubo T.
- Journal Title
  
  Hum. Mol. Genet.
  
  Volume: 22(22) Pages: 4474-4484
- DOI
  10.1093/hmg/ddt296
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117006, KAKENHI-PROJECT-23687032, KAKENHI-PROJECT-24687027, KAKENHI-PROJECT-24800015, KAKENHI-PROJECT-25650074
[Journal Article] Neuronal activity and secreted amyloid β lead to altered amyloid β precursor protein and presenilin 1 interactions2013
- Author(s)
  Xuejing Li, Kengo Uemura, Tadafumi Hashimoto, Navine Nasser-Ghodsi, Muriel Arimon, Christina M Lill, Isabella Palazzolo, Dimitri Krainc, Bradley T Hyman, and Oksana Berezovska
- Journal Title
  
  Neurobiology of Disease
  
  Volume: 50 Pages: 127-134
- DOI
  10.1016/j.nbd.2012.10.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24800015
[Journal Article] Brain interstitial oligomeric amyloid beta increases with age and is resistant to clearance from brain in a mouse model of Alzheimer's disease2013
- Author(s)
  Shuko Takeda, Tadafumi Hashimoto, Alberto Serrano-Pozo, Allyson D Roe, Tara L Spires-Jones, and Bradley T Hyman
- Journal Title
  
  FASEB. J
  
  Volume: 27(8) Pages: 3239-3248
- DOI
  10.1096/fj.13-229666
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24800015
[Journal Article] Human ApoE isoforms delivered via gene transfer differentially modulate Alzheimer's disease by affecting amyloid deposition, clearance, and neurotoxicity2013
- Author(s)
  Eloise Hudry, Jonathan Dashkoff, Allyson Lee, Shuko Takeda, Robert M. Koffie, Tadafumi Hashimoto, Maria Scheel, Tara Spires-Jones, Michal Arbel-Ornath, Rebecca Betensky, Beverly L Davidson, and Bradley T Hyman
- Journal Title
  
  Sci. Trans. Med.
  
  Volume: 5(212)
- DOI
  10.1126/scitranslmed.3007000
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24800015
[Journal Article] Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid beta peptide2012
- Author(s)
  T.Hashimoto, A.Serrano-Pozo, Y.Hori, et al
- Journal Title
  
  J. Neurosci.
  
  Volume: 32 Pages: 15181-15192
- DOI
  10.1523/jneurosci.1542-12.2012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J09836, KAKENHI-PROJECT-24800015
[Journal Article] The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system2012
- Author(s)
  Hwan-Ching Tai, Alberto Serrano-Pozo, Tadafumi Hashimoto, Matthew P Frosch, Tara L Spires-Jones, and Bradley T Hyman
- Journal Title
  
  Am. J. Pathol.
  
  Volume: 181 Pages: 1426-1435
- DOI
  10.1016/j.ajpath.2012.06.033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24800015
[Journal Article] Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide2012
- Author(s)
  Tadafumi Hashimoto
- Journal Title
  
  Journal of Neuroscience
  
  Volume: 32 Pages: 15181-15192
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24800015
[Journal Article] The Tottori (D7N) and English (H6R) familial Alzheimer's disease mutations accelerate All fibril formation without increasing protofibril formation2007
- Author(s)
  Hori Y, Hashimoto T, Wakutani Y, Urakami K, Nakashima K, Condron MM, Tsubuki S, Saido TC, Teplow DB, Iwatsubo T
- Journal Title
  
  J Biol Chem 282
  
  Pages: 4916-4923
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17200025
[Journal Article] Major involvement of low-density lipoprotein receptor-related protein 1 in the clearance of plasma free amyloid β-peptide by the liver2006
- Author(s)
  Tamaki C, Ohtsuki S, Iwatsubo T, Hashimoto T, Yamada K, Yabuki C, Terasaki T
- Journal Title
  
  Pharmaceut Res 23
  
  Pages: 1407-1416
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17200025
[Journal Article] Patholoeical effects of CLAC in the brains of APP/CLAC-P double transgenic mice2006
- Author(s)
  Hashimoto T
- Journal Title
  
  Alzheimer's Dementia 2
- Data Source
  KAKENHI-PROJECT-17790050
[Journal Article] CLAC binds to amyloid β peptides through the positively-charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils2005
- Author(s)
  Osada Y, Hashimoto T, Nishimura A, Matsuo Y Wakabayashi T, Iwatsubo T.
- Journal Title
  
  J Biol Chem 280
  
  Pages: 8596-8605
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17200025
[Presentation] FUSの細胞間伝播機序に関する研究2018
- Author(s)
  渡邊成晃、松川浩二、橋本唯史、岩坪威
- Organizer
  第37回日本認知症学会
- Data Source
  KAKENHI-PROJECT-18K07364
[Presentation] FUS induces neurodegeneration through its low-complexity domain in the drosophila retina.2018
- Author(s)
  Tadafumi Hashimoto, Taisei Matsumoto, Yuya Kishino, Koji Matsukawa, Naruaki Watanabe, Tomoko Wakabayashi, Takeshi Iwatsubo
- Organizer
  Neuroscience2018
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05687
[Presentation] FUSの細胞間伝播機序に関する研究2018
- Author(s)
  渡邊成晃、松川浩二、橋本唯史、岩坪威
- Organizer
  第37回日本認知症学会
- Data Source
  KAKENHI-PUBLICLY-17H05687
[Presentation] FUS induces neurodegeneration through its low-complexity domain in the drosophila retina.2018
- Author(s)
  Tadafumi Hashimoto, Taisei Matsumoto, Yuya Kishino, Koji Matsukawa, Naruaki Watanabe, Tomoko Wakabayashi, Takeshi Iwatsubo
- Organizer
  Neuroscience2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07364
[Presentation] Characterization of the seed Abeta oligomers in the brains of APP transgenic mice2018
- Author(s)
  Mayu Hakozaki-Kashiwagi, Yasushi Naka, Tomohiko Tajiri, Masashi Fukayama, Tadafumi Hashimoto, Takeshi Iwatsubo
- Organizer
  19th International Congress of Neuropathology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07364
[Presentation] Characterization of the seed Abeta oligomers in the brains of APP transgenic mice2018
- Author(s)
  Mayu Hakozaki-Kashiwagi, Yasushi Naka, Tomohiko Tajiri, Masashi Fukayama, Tadafumi Hashimoto, Takeshi Iwatsubo
- Organizer
  19th International Congress of Neuropathology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04193
[Presentation] ヒト型とマウス型apolipoprotein EがAbeta脳内dynamicsに与える影響の相違2018
- Author(s)
  粉川明日香、大野裕太郎、橋本唯史、岩坪威
- Organizer
  第37回日本認知症学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04193
[Presentation] ヒト型とマウス型apolipoprotein EがAbeta脳内dynamicsに与える影響の相違2018
- Author(s)
  粉川明日香、大野裕太郎、橋本唯史、岩坪威
- Organizer
  第37回日本認知症学会
- Data Source
  KAKENHI-PROJECT-18K07364
[Presentation] アミロイド斑蓄積のseedとして働く可溶性Abetaオリゴマーの同定2018
- Author(s)
  箱崎眞結、仲泰史、田尻智也、深山正久、橋本唯史、岩坪威
- Organizer
  第37回日本認知症学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04193
[Presentation] アミロイド斑蓄積のseedとして働く可溶性Abetaオリゴマーの同定2018
- Author(s)
  箱崎眞結、仲泰史、田尻智也、深山正久、橋本唯史、岩坪威
- Organizer
  第37回日本認知症学会
- Data Source
  KAKENHI-PROJECT-18K07364
[Presentation] Casein kinase 1 delta/ipsilon がFUSの神経毒性に与える影響に関する検討2017
- Author(s)
  岸野祐也、松川浩二、野中隆、松本大成、長谷川成人、橋本唯史、岩坪威
- Organizer
  第36回日本認知症学会
- Data Source
  KAKENHI-PROJECT-15K08297
[Presentation] Characterization of the high molecular weight Ab oligomers derived from the brains of APP transgenic mice2017
- Author(s)
  Tadafumi Hashimoto, Yasushi Naka, Tomoya Tajiri, Mayu Hakozaki-Kashiwagi, Takeshi Iwatsubo
- Organizer
  Neuroscience2017
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05687
[Presentation] Differential effects of human and mouse apolipoprotein E on the metabolism and aggregation of amyloid-beta peptides2017
- Author(s)
  Asuka Kokawa, Yutaro Ohno, Tadafumi Hashimoto, Takeshi Iwatsubo
- Organizer
  Neuroscience2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08297
[Presentation] Characterization of the high molecular weight Abeta oligomers derived from the brains of APP transgenic mice2017
- Author(s)
  Tadafumi Hashimoto, Yasushi Naka, Tomoya Tajiri, Mayu Hakozaki-Kashiwagi, Takeshi Iwatsubo
- Organizer
  Neuroscience2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04193
[Presentation] Differential effects of human and mouse apolipoprotein E on the metabolism and aggregation of amyloid-b peptides2017
- Author(s)
  Asuka Kokawa, Yutaro Ohno, Tadafumi Hashimoto, Takeshi Iwatsubo
- Organizer
  Neuroscience2017
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05687
[Presentation] Differential effects of human and mouse apolipoprotein E on the metabolism and aggregation of amyloid-beta peptides2017
- Author(s)
  Asuka Kokawa, Yutaro Ohno, Tadafumi Hashimoto, Takeshi Iwatsubo
- Organizer
  Neuroscience2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04193
[Presentation] Casein kinase 1 delta/ipsilonがFUSの神経毒性に与える影響に関する検討2017
- Author(s)
  岸野祐也、松川浩二、野中隆、松本大成、長谷川成人、橋本唯史、岩坪威
- Organizer
  日本認知症学会
- Data Source
  KAKENHI-PUBLICLY-17H05687
[Presentation] Characterization of the high molecular weight Abeta oligomers derived from the brains of APP transgenic mice2017
- Author(s)
  Tadafumi Hashimoto, Yasushi Naka, Tomoya Tajiri, Mayu Hakozaki-Kashiwagi, Takeshi Iwatsubo
- Organizer
  Neuroscience2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08297
[Presentation] The relationship between insulin resistance and amyloid pathology in diabetic AD model mice2017
- Author(s)
  K Matsui, K Yamaguchi, A Mano, T Sano, T Hashimoto, T Kubota, T Kadowaki, T Wakabayashi, T Iwatsubo
- Organizer
  Neuroscience2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08297
[Presentation] ヒトapoEがAβの脳内dynamicsに与える影響の解明2016
- Author(s)
  粉川明日香、大野裕太郎、橋本唯史、岩坪威
- Organizer
  第35回日本認知症学会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-15K08297
[Presentation] Roles of Ab plaques on the dynamics of soluble Ab in the brains of APP transgenic mice.2016
- Author(s)
  Yasushi Naka, Tomoko Wanabayashi, Tadafumi Hashimoto, Takeshi Iwatsubo
- Organizer
  Neuroscience 2016
- Place of Presentation
  San Diego, USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08297
[Presentation] TDP-43はAtg1/ULK1のプロセシング異常を介して神経変性を引き起こす2016
- Author(s)
  松川浩二、岸野祐也、若林朋子、橋本唯史、岩坪威
- Organizer
  第35回日本認知症学会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-15K08297
[Presentation] Development of a novel cell-based model for oligomerization and intercellular transmission of FUS2016
- Author(s)
  Tadafumi Hashimoto, Taisei Matsumoto, Koji Matsukawa, Naruaki Watanabe, Tomoko Wakabayashi, Takeshi Iwatsubo
- Organizer
  Neuroscience 2016
- Place of Presentation
  San Diego, USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08297
[Presentation] Novel cellular and in vivo models for intercellular transmission of FUS2016
- Author(s)
  Tadafumi Hashimoto, Taisei Matsumoto, Koji Matsukawa, Naruaki Watanabe, Tomoko Wakabayashi, Takeshi Iwatsubo
- Organizer
  Gordon Research Conferences. Neurobiology of brain disorders
- Place of Presentation
  Girona, Spain
- Year and Date
  2016-08-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08297
[Presentation] Self-assembly of FUS is required for the degeneration of retinal photoreceptor neurons in transgenic Drosophila melanogaster overexpressing human FUS2015
- Author(s)
  Tadafumi Hashimoto, Taisei Matsumoto, Hayato Kunugi, Koji Matsukawa, Tomoko Wakabayashi, Takeshi Iwatsubo
- Organizer
  10th Brain Research Conference
- Place of Presentation
  Chicago, USA
- Year and Date
  2015-10-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08297
[Presentation] CLAC alters the morphology and dynamics of amyloid-β peptides in the brain2015
- Author(s)
  Tadafumi Hashimoto, Yasushi Naka, Daisuke Fujii, Mayu Kashiwagi, Tomoko Wakabayashi, Takeshi Iwatsubo
- Organizer
  Neuroscience 2015
- Place of Presentation
  Chicago, USA
- Year and Date
  2015-10-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08297
[Presentation] オプとジェネティックスを用いた神経活動依存的なAβ分泌・蓄積の検討2013
- Author(s)
  山本薫、奥野浩行、Cirrito JR, Holtzman DM, Yizhar O, Fenno LF, Deisseroth K, 尾藤晴彦、若林朋子、橋本唯史、岩坪威
- Organizer
  第５４回神経病理学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24800015
[Presentation] Two distinct pathways leading to degeneration in transgenic Drosophila melanogaster overexpressing human FUS2013
- Author(s)
  Tadafumi Hashimoto, Hayato Kunugi, Koji Matsukawa, hirokazu Uchigami, Ryoko Ihara, Takahiro Chihara, Masayuki Miura, Tomoko Wakabayashi, and Takeshi Iwatsubo
- Organizer
  Alzheimer's Association International Conference
- Place of Presentation
  Boston, USA.
- Year and Date
  2013-07-14
- Data Source
  KAKENHI-PROJECT-24800015
[Presentation] Remodeling of the morphology of β-amyloid plaques by CLAC in the brains of transgenic mice2012
- Author(s)
  Tadafumi Hashimoto
- Organizer
  Society for Neuroscience
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-24800015
[Presentation] オプとジェネティックスを用いた神経活動依存的なAβ分泌・蓄積の検討2012
- Author(s)
  山本薫、奥野浩行、尾藤晴彦、若林朋子、橋本唯史、岩坪威
- Organizer
  第３１回　日本認知症学会
- Place of Presentation
  筑波市
- Invited
- Data Source
  KAKENHI-PLANNED-22110003
[Presentation] Remodeling of the morphology of beta-amyloid plaques by CLAC in the brains of transgenic mice2012
- Author(s)
  Tadafumi Hashimoto, Daisuke Fujii, Mayu Kashiwagi, Yuko Matsuo, Yusuke Matsura, Tomoko Sakakura, Hisatomo Kowa, David Westaway, Tomoko Wakabayashi, and Takeshi Iwatsubo
- Organizer
  Society for Neuroscience
- Place of Presentation
  New Oreleans, USA.
- Year and Date
  2012-10-15
- Data Source
  KAKENHI-PROJECT-24800015
[Presentation] Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid beta peptide. Gordon Research Conferences, Neurobiology of brain disorders2012
- Author(s)
  Tadafumi Hashimoto, Alberto Serrano-Pozo, Yukiko Hori, Hwan-Ching Tai, Kenneth W Adams, Shuko Takeda, Daniel Joyner, Diana H Thyssen, Brian J Bacskai, Matthew P Frosch, Tara L Spires-Jones, Mary Beth Finn, David M Holtzman, and Bradley T Hyman
- Organizer
  Neurobiology of brain disorders
- Place of Presentation
  Easton, USA.
- Data Source
  KAKENHI-PROJECT-24800015
[Presentation] Isoform-specific effects of apolipoprotein E on the stability of Aβ protofibrils2007
- Author(s)
  Hashimoto T
- Organizer
  37th society for neuroscience
- Place of Presentation
  San Diego
- Year and Date
  2007-11-04
- Data Source
  KAKENHI-PROJECT-19790050
[Presentation] Amyloid β aggregation: role of interactor proteins2007
- Author(s)
  Hashimoto T
- Organizer
  IBRO 2007
- Place of Presentation
  Melbourne
- Year and Date
  2007-07-15
- Data Source
  KAKENHI-PROJECT-19790050
[Presentation] Two distinct pathways leading to degeneration in transgenic Drosophila melanogaster overexpressing human FUS
- Author(s)
  Hashimoto T, Kunugi H, Matsukawa K, Uchigami H, Ihara R, Chihara T, Miura M, Wakabayashi T, Iwatsubo T
- Organizer
  Alzheimer's Association International Conference
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-24800015

1. IWATSUBO Takeshi (50223409)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
2. WAKABAYASHI Tomoko (20530330)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. ITO Genta (10431892)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 高杉展正 (60436590)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 山田薫 (00735152)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. IWATA Atsushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. KAMIKUBO Yuji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 佐藤隆史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 倉永英里奈

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 千原崇裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
11. 尾藤晴彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 山本亘彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 橋本亮太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 饗場篤

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 玉岡晃

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 長谷川成人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 高橋隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 岩田孝吉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 村山繁雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 堀由起子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 貫名信行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 桜井正樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hashimoto Tadafumi 橋本 唯史

HASHIMOTO Tadafumi 橋本 唯史

Research Projects

Research Products

Co-Researchers

Elucidation of physiological and pathological roles of TDP-43 through autophagic machineryPrincipal InvestigatorOngoing

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アルツハイマー病発症機構における脂質フリッパーゼの役割の解析と予防・治療法の開発Ongoing

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ALS病因タンパク質FUSの細胞間伝播及び神経細胞障害性発揮メカニズムの解明Principal Investigator

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アルツハイマー病Aβの脳内エコノミー破綻によるタウ依存的神経障害の分子基盤解明Ongoing

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Elucidation of the pathomechanism of neurodegeneration induced by TDP-43Principal Investigator

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Study for the metabolism and neurotoxicity of amyloid beta peptide oligomersPrincipal Investigator

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Elucidation of the molecular pathology of Alzheimer's disease focusing on the synapses toward therapies

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アルツハイマー病脳におけるアミロイド構成蛋白質CLACに関する研究Principal Investigator

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アルツハイマー病新規アミロイド構成蛋白質CLACに関する病態生化学的研究Principal Investigator

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Molecular and cell biological studies on the production, aggregation and clearance of Alzheimer amyloid β peptides.

Principal Investigator

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アルツハイマー病脳老人斑アミロイドを構成する新規タンパク質CLACに関する研究Principal Investigator

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[Journal Article] Chronic cerebral hypoperfusion shifts the equilibrium of amyloid β oligomers to aggregation-prone species with higher molecular weight2019

Author(s)

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DOI

Data Source

[Journal Article] Self-assembly of FUS through its low-complexity domain contributes to neurodegeneration2018

Author(s)

Journal Title

DOI

Hashimoto Tadafumi 橋本唯史

HASHIMOTO Tadafumi 橋本唯史