Hashimoto Tadafumi 橋本唯史

… Alternative Names

Researcher Number	30334337
Other IDs
Affiliation (Current)	2019: 東京大学, 大学院医学系研究科(医学部), 特任准教授
Affiliation (based on the past Project Information) *help	2016 – 2019: 東京大学, 大学院医学系研究科(医学部), 特任准教授 2017: 東京大学, 医学(系)研究科(研究院), 助教 2017: 東京大学, 医学(系)研究科(研究院), 特任准教授 2015: 東京大学, 医学(系)研究科(研究院), 講師 2014: 東京大学, 医学(系)研究科(研究院), 助教 … More
Review Section/Research Field	Principal Investigator Biological pharmacy / Nerve anatomy/Neuropathology / Pathological medical chemistry / Biological Sciences / Basic Section 51030:Pathophysiologic neuroscience-related Except Principal Investigator Biological Sciences / Neurochemistry/Neuropharmacology / Neurology / Biological pharmacy
Keywords	Principal Investigator CLAC / アルツハイマー病 / アミロイドβ蛋白質 / 筋萎縮性側索硬化症 / 前頭側頭葉変性症 / 神経変性疾患 / アミロイドβペプチド / コラーゲン / 老人斑 / 神経科学 … More Except Principal Investigator アルツハイマー病 / Aβ / アミロイド / アルツハイマー / βアミロイド / アミロイドβペプチド / シナプス / 光遺伝学 / 神経活動 / マイクロダイアリシス / γセクレターゼ / 結合タンパク / Alzheimer's disease / γ-Secretase / Amyloid / amyloid binding protein / タウ / 脳神経疾患 / リピッドフリッパーゼ / アミロイドβ Less

Elucidation of physiological and pathological roles of TDP-43 through autophagic machineryPrincipal InvestigatorOngoing
- Principal Investigator
  
  橋本唯史
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  The University of Tokyo
ALS病因タンパク質FUSの細胞間伝播及び神経細胞障害性発揮メカニズムの解明Principal InvestigatorOngoing
- Principal Investigator
  
  橋本唯史
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
アルツハイマー病Aβの脳内エコノミー破綻によるタウ依存的神経障害の分子基盤解明Ongoing
- Principal Investigator
  
  岩坪威
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  The University of Tokyo
アルツハイマー病発症機構における脂質フリッパーゼの役割の解析と予防・治療法の開発Ongoing
- Principal Investigator
  
  高杉展正
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Okayama University
Elucidation of the pathomechanism of neurodegeneration induced by TDP-43Principal Investigator
- Principal Investigator
  
  Hashimoto Tadafumi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokyo
Study for the metabolism and neurotoxicity of amyloid beta peptide oligomersPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Tadafumi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Research Activity start-up
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  The University of Tokyo
Elucidation of the molecular pathology of Alzheimer's disease focusing on the synapses toward therapies
- Principal Investigator
  
  IWATSUBO Takeshi
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
アルツハイマー病脳におけるアミロイド構成蛋白質CLACに関する研究Principal Investigator
- Principal Investigator
  
  橋本唯史
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
アルツハイマー病新規アミロイド構成蛋白質CLACに関する病態生化学的研究Principal Investigator
- Principal Investigator
  
  橋本唯史
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
Molecular and cell biological studies on the production, aggregation and clearance of Alzheimer amyloid β peptides.
- Principal Investigator
  
  IWATSYBO Takeshi
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  The University of Tokyo
アルツハイマー病脳老人斑アミロイドを構成する新規タンパク質CLACに関する研究Principal Investigator
- Principal Investigator
  
  橋本唯史
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo

All 2018 2017 2016 2015 2014 2013 2012 2007 2006 2005 Other

All Journal Article Presentation

[Journal Article] Self-assembly of FUS through its low-complexity domain contributes to neurodegeneration2018
- Author(s)
  Taisei Matsumoto, Koji Matsukawa, Naruaki Watanabe, Yuya Kishino, Hayato Kunugi, Ryoko Ihara, Tomoko Wakabayashi, Tadafumi Hashimoto, Takeshi Iwatsubo
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 印刷中
- DOI
  10.1093/hmg/ddy046
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-17H05687, KAKENHI-PROJECT-15K08297
[Journal Article] Soluble oligomeric amyloid-beta induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain2017
- Author(s)
  Michal Arbel-Ornath, Eloise Hudry, Josiah R Bovine, Tadafumi Hashimoto, Shuko Takeda, Kishore V Kuchbhotla, Steven Hou, Carli R Lattarulo, Arianna M Belcher, Naomi Shakerdge, et al
- Journal Title
  
  Molecular Neurodegeneration
  
  Volume: 12 Pages: 27-27
- DOI
  10.1186/s13024-017-0169-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05687, KAKENHI-PROJECT-15K08297
[Journal Article] Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer's disease.2017
- Author(s)
  Mano T, Nagata K, Nonaka T, Tarutani A, Koshi-Mano K, Tsuchida T, Ohtomo R, Takahashi-Fujigasaki J, Yamashita S, Ohyagi Y, Yamazaki R, Tsuji S, Tamaoka A, Ikeuchi T, Saido CT, Iwatsubo T, Ushijima T, Murayama S, Hasegawa M, Iwata A, et al.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 114 Issue: 45
- DOI
  10.1073/pnas.1707151114
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09664, KAKENHI-PROJECT-17K16113, KAKENHI-PUBLICLY-17H05687, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356, KAKENHI-PROJECT-16H05319, KAKENHI-PROJECT-15K08297, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-16H06297
[Journal Article] Familial ALS-linked mutations in Profilin 1 exacerbated TDP-43 induced degeneration in the retina of Drosophila Melanogaster through an increase in the cytoplasmic localization of TDP-43.2016
- Author(s)
  Matsukawa K, Hashimoto T, Matsumoto T, Ihara R, Chihara T, Miura M, Wakabayashi T, Iwatsubo T.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 291 Pages: 23464-23476
- DOI
  10.1074/jbc.m116.729152
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04375, KAKENHI-PROJECT-14J06189, KAKENHI-PROJECT-15K08297
[Journal Article] Calcium-responsive transactivator (CREST) protein shares a set of structural and functional traits with other proteins associated with amyotrophic lateral sclerosis.2015
- Author(s)
  Michail S. Kukharsky, Annamaria Quintiero, Taisei Matsumoto, Koji Matsukawa, Haiyan An, Tadafumi Hashimoto, Takeshi Iwatsubo, Vladimir L. Buchman, Tatyana A. Shelkovnikova
- Journal Title
  
  Molecular Neurodegeneration
  
  Volume: 10
- DOI
  10.1186/s13024-015-0014-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08297, KAKENHI-PROJECT-14J06189
[Journal Article] Chronic optogenetic activation augments abeta pathology in a mouse model of Alzheimer disease.2015
- Author(s)
  Kaoru Yamamoto, Zen-ichi Tanei, Tadafumi Hashimoto, Tomoko Wakabayashi, Hiroyuki Okuno, Yasushi Naka, Ofer Yizhar, Lief E. Fenno, Masashi Fukayama, Haruhiko Bito, John R. Cirrito, David M. Holtzman, Karl Deisseroth, Takeshi Iwatsubo
- Journal Title
  
  Cell Rep
  
  Volume: 11 Pages: 859-865
- DOI
  10.1016/j.celrep.2015.04.017
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-22110003, KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-15K08297, KAKENHI-PROJECT-15H02358
[Journal Article] Role of Apolipoprotein E in β-Amyloidogenesis: Isoform-specific effects on protofibril to fibril conversion of Aβ in vitro and brain Aβ deposition in vivo.2015
- Author(s)
  Yukiko Hori, Tadafumi Hashimoto, Hidetoshi Nomoto, Bradley T Hyman, Takeshi Iwatsubo
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 290 Pages: 15163-15174
- DOI
  10.1074/jbc.m114.622209
- Peer Reviewed / Open Access / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08297, KAKENHI-PROJECT-26893042
[Journal Article] RNA aptamer probes as optical imaging agents for the detection of amyloid plaques2014
- Author(s)
  Christian T Farrar, Christopher M William, Eloise Hudry, Tadafumi Hashimoto, and Hyman BT
- Journal Title
  
  PLoS One
  
  Volume: 9(2)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24800015
[Journal Article] CLAC-P/collagen type XXV is required for the intramuscular innervation of motoneurons during neuromuscular development2014
- Author(s)
  Tanaka T, Wakabayashi T, Oizumi H, Nishio S, Sato T, Harada A, Fujii D, Matsuo Y, Hashimoto T, Iwatsubo T.
- Journal Title
  
  j. Neurosci.
  
  Volume: 34 Pages: 1370-1379
- DOI
  10.1523/jneurosci.2440-13.2014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591347, KAKENHI-PROJECT-24390046, KAKENHI-PROJECT-24659084, KAKENHI-PROJECT-24700373, KAKENHI-PROJECT-24800015, KAKENHI-PUBLICLY-25113517
[Journal Article] CLAC-P/collagen type XXV is required for the intramuscular innervation of motoneurns during neuromuscular development2014
- Author(s)
  Tomohiro Tanaka, Tomoko Wakabayashi, Hiroaki Oizumi, Shu Nishio, Takashi Sato, Akihiro Harada, Daisuke Fujii, Yuko Matsuo, Tadafumi Hashimoto, and Takeshi Iwatsubo
- Journal Title
  
  J. Neurosci.
  
  Volume: 34(4) Pages: 1370-1379
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24800015
[Journal Article] Microfluidic chemotaxis platform for differentiating the roles of soluble and bound amyloid-beta on microglia accumulation2013
- Author(s)
  Hansang Cho, Tadafumi Hashimoto, Elisabeth Wong, Yukiko Hori, Levi B Wood, Lingzhi Zhao, Kevin M Daigis, Bradley T Hyman, and Daniel Irimia
- Journal Title
  
  Sci. Rep.
  
  Volume: 3 Pages: 1823-1823
- DOI
  10.1038/srep01823
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24800015
[Journal Article] RNA binding mediates neurotoxicity in the transgenic Drosophila model of TDP-43 proteinopathy2013
- Author(s)
  Ihara R, Matsukawa K, Nagata Y, Kunugi H, Tsuji S, Chihara T, Kuranaga E, Miura M, Wakabayashi T, Hashimoto T, Iwatsubo T.
- Journal Title
  
  Hum. Mol. Genet.
  
  Volume: 22(22) Pages: 4474-4484
- DOI
  10.1093/hmg/ddt296
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117006, KAKENHI-PROJECT-23687032, KAKENHI-PROJECT-24687027, KAKENHI-PROJECT-24800015, KAKENHI-PROJECT-25650074
[Journal Article] Neuronal activity and secreted amyloid β lead to altered amyloid β precursor protein and presenilin 1 interactions2013
- Author(s)
  Xuejing Li, Kengo Uemura, Tadafumi Hashimoto, Navine Nasser-Ghodsi, Muriel Arimon, Christina M Lill, Isabella Palazzolo, Dimitri Krainc, Bradley T Hyman, and Oksana Berezovska
- Journal Title
  
  Neurobiology of Disease
  
  Volume: 50 Pages: 127-134
- DOI
  10.1016/j.nbd.2012.10.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24800015
[Journal Article] Brain interstitial oligomeric amyloid beta increases with age and is resistant to clearance from brain in a mouse model of Alzheimer's disease2013
- Author(s)
  Shuko Takeda, Tadafumi Hashimoto, Alberto Serrano-Pozo, Allyson D Roe, Tara L Spires-Jones, and Bradley T Hyman
- Journal Title
  
  FASEB. J
  
  Volume: 27(8) Pages: 3239-3248
- DOI
  10.1096/fj.13-229666
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24800015
[Journal Article] Human ApoE isoforms delivered via gene transfer differentially modulate Alzheimer's disease by affecting amyloid deposition, clearance, and neurotoxicity2013
- Author(s)
  Eloise Hudry, Jonathan Dashkoff, Allyson Lee, Shuko Takeda, Robert M. Koffie, Tadafumi Hashimoto, Maria Scheel, Tara Spires-Jones, Michal Arbel-Ornath, Rebecca Betensky, Beverly L Davidson, and Bradley T Hyman
- Journal Title
  
  Sci. Trans. Med.
  
  Volume: 5(212)
- DOI
  10.1126/scitranslmed.3007000
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24800015
[Journal Article] Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid beta peptide2012
- Author(s)
  T.Hashimoto, A.Serrano-Pozo, Y.Hori, et al
- Journal Title
  
  J. Neurosci.
  
  Volume: 32 Pages: 15181-15192
- DOI
  10.1523/jneurosci.1542-12.2012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J09836, KAKENHI-PROJECT-24800015
[Journal Article] The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system2012
- Author(s)
  Hwan-Ching Tai, Alberto Serrano-Pozo, Tadafumi Hashimoto, Matthew P Frosch, Tara L Spires-Jones, and Bradley T Hyman
- Journal Title
  
  Am. J. Pathol.
  
  Volume: 181 Pages: 1426-1435
- DOI
  10.1016/j.ajpath.2012.06.033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24800015
[Journal Article] Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide2012
- Author(s)
  Tadafumi Hashimoto
- Journal Title
  
  Journal of Neuroscience
  
  Volume: 32 Pages: 15181-15192
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24800015
[Journal Article] The Tottori (D7N) and English (H6R) familial Alzheimer's disease mutations accelerate All fibril formation without increasing protofibril formation2007
- Author(s)
  Hori Y, Hashimoto T, Wakutani Y, Urakami K, Nakashima K, Condron MM, Tsubuki S, Saido TC, Teplow DB, Iwatsubo T
- Journal Title
  
  J Biol Chem 282
  
  Pages: 4916-4923
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17200025
[Journal Article] Major involvement of low-density lipoprotein receptor-related protein 1 in the clearance of plasma free amyloid β-peptide by the liver2006
- Author(s)
  Tamaki C, Ohtsuki S, Iwatsubo T, Hashimoto T, Yamada K, Yabuki C, Terasaki T
- Journal Title
  
  Pharmaceut Res 23
  
  Pages: 1407-1416
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17200025
[Journal Article] Patholoeical effects of CLAC in the brains of APP/CLAC-P double transgenic mice2006
- Author(s)
  Hashimoto T
- Journal Title
  
  Alzheimer's Dementia 2
- Data Source
  KAKENHI-PROJECT-17790050
[Journal Article] CLAC binds to amyloid β peptides through the positively-charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils2005
- Author(s)
  Osada Y, Hashimoto T, Nishimura A, Matsuo Y Wakabayashi T, Iwatsubo T.
- Journal Title
  
  J Biol Chem 280
  
  Pages: 8596-8605
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17200025
[Presentation] Casein kinase 1 delta/ipsilon がFUSの神経毒性に与える影響に関する検討2017
- Author(s)
  岸野祐也、松川浩二、野中隆、松本大成、長谷川成人、橋本唯史、岩坪威
- Organizer
  第36回日本認知症学会
- Data Source
  KAKENHI-PROJECT-15K08297
[Presentation] Characterization of the high molecular weight Ab oligomers derived from the brains of APP transgenic mice2017
- Author(s)
  Tadafumi Hashimoto, Yasushi Naka, Tomoya Tajiri, Mayu Hakozaki-Kashiwagi, Takeshi Iwatsubo
- Organizer
  Neuroscience2017
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05687
[Presentation] Differential effects of human and mouse apolipoprotein E on the metabolism and aggregation of amyloid-beta peptides2017
- Author(s)
  Asuka Kokawa, Yutaro Ohno, Tadafumi Hashimoto, Takeshi Iwatsubo
- Organizer
  Neuroscience2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08297
[Presentation] Characterization of the high molecular weight Abeta oligomers derived from the brains of APP transgenic mice2017
- Author(s)
  Tadafumi Hashimoto, Yasushi Naka, Tomoya Tajiri, Mayu Hakozaki-Kashiwagi, Takeshi Iwatsubo
- Organizer
  Neuroscience2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04193
[Presentation] Differential effects of human and mouse apolipoprotein E on the metabolism and aggregation of amyloid-b peptides2017
- Author(s)
  Asuka Kokawa, Yutaro Ohno, Tadafumi Hashimoto, Takeshi Iwatsubo
- Organizer
  Neuroscience2017
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05687
[Presentation] Differential effects of human and mouse apolipoprotein E on the metabolism and aggregation of amyloid-beta peptides2017
- Author(s)
  Asuka Kokawa, Yutaro Ohno, Tadafumi Hashimoto, Takeshi Iwatsubo
- Organizer
  Neuroscience2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04193
[Presentation] Casein kinase 1 delta/ipsilonがFUSの神経毒性に与える影響に関する検討2017
- Author(s)
  岸野祐也、松川浩二、野中隆、松本大成、長谷川成人、橋本唯史、岩坪威
- Organizer
  日本認知症学会
- Data Source
  KAKENHI-PUBLICLY-17H05687
[Presentation] Characterization of the high molecular weight Abeta oligomers derived from the brains of APP transgenic mice2017
- Author(s)
  Tadafumi Hashimoto, Yasushi Naka, Tomoya Tajiri, Mayu Hakozaki-Kashiwagi, Takeshi Iwatsubo
- Organizer
  Neuroscience2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08297
[Presentation] The relationship between insulin resistance and amyloid pathology in diabetic AD model mice2017
- Author(s)
  K Matsui, K Yamaguchi, A Mano, T Sano, T Hashimoto, T Kubota, T Kadowaki, T Wakabayashi, T Iwatsubo
- Organizer
  Neuroscience2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08297
[Presentation] ヒトapoEがAβの脳内dynamicsに与える影響の解明2016
- Author(s)
  粉川明日香、大野裕太郎、橋本唯史、岩坪威
- Organizer
  第35回日本認知症学会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-15K08297
[Presentation] Roles of Ab plaques on the dynamics of soluble Ab in the brains of APP transgenic mice.2016
- Author(s)
  Yasushi Naka, Tomoko Wanabayashi, Tadafumi Hashimoto, Takeshi Iwatsubo
- Organizer
  Neuroscience 2016
- Place of Presentation
  San Diego, USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08297
[Presentation] TDP-43はAtg1/ULK1のプロセシング異常を介して神経変性を引き起こす2016
- Author(s)
  松川浩二、岸野祐也、若林朋子、橋本唯史、岩坪威
- Organizer
  第35回日本認知症学会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-15K08297
[Presentation] Development of a novel cell-based model for oligomerization and intercellular transmission of FUS2016
- Author(s)
  Tadafumi Hashimoto, Taisei Matsumoto, Koji Matsukawa, Naruaki Watanabe, Tomoko Wakabayashi, Takeshi Iwatsubo
- Organizer
  Neuroscience 2016
- Place of Presentation
  San Diego, USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08297
[Presentation] Novel cellular and in vivo models for intercellular transmission of FUS2016
- Author(s)
  Tadafumi Hashimoto, Taisei Matsumoto, Koji Matsukawa, Naruaki Watanabe, Tomoko Wakabayashi, Takeshi Iwatsubo
- Organizer
  Gordon Research Conferences. Neurobiology of brain disorders
- Place of Presentation
  Girona, Spain
- Year and Date
  2016-08-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08297
[Presentation] Self-assembly of FUS is required for the degeneration of retinal photoreceptor neurons in transgenic Drosophila melanogaster overexpressing human FUS2015
- Author(s)
  Tadafumi Hashimoto, Taisei Matsumoto, Hayato Kunugi, Koji Matsukawa, Tomoko Wakabayashi, Takeshi Iwatsubo
- Organizer
  10th Brain Research Conference
- Place of Presentation
  Chicago, USA
- Year and Date
  2015-10-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08297
[Presentation] CLAC alters the morphology and dynamics of amyloid-β peptides in the brain2015
- Author(s)
  Tadafumi Hashimoto, Yasushi Naka, Daisuke Fujii, Mayu Kashiwagi, Tomoko Wakabayashi, Takeshi Iwatsubo
- Organizer
  Neuroscience 2015
- Place of Presentation
  Chicago, USA
- Year and Date
  2015-10-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08297
[Presentation] オプとジェネティックスを用いた神経活動依存的なAβ分泌・蓄積の検討2013
- Author(s)
  山本薫、奥野浩行、Cirrito JR, Holtzman DM, Yizhar O, Fenno LF, Deisseroth K, 尾藤晴彦、若林朋子、橋本唯史、岩坪威
- Organizer
  第５４回神経病理学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24800015
[Presentation] Two distinct pathways leading to degeneration in transgenic Drosophila melanogaster overexpressing human FUS2013
- Author(s)
  Tadafumi Hashimoto, Hayato Kunugi, Koji Matsukawa, hirokazu Uchigami, Ryoko Ihara, Takahiro Chihara, Masayuki Miura, Tomoko Wakabayashi, and Takeshi Iwatsubo
- Organizer
  Alzheimer's Association International Conference
- Place of Presentation
  Boston, USA.
- Year and Date
  2013-07-14
- Data Source
  KAKENHI-PROJECT-24800015
[Presentation] Remodeling of the morphology of β-amyloid plaques by CLAC in the brains of transgenic mice2012
- Author(s)
  Tadafumi Hashimoto
- Organizer
  Society for Neuroscience
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-24800015
[Presentation] オプとジェネティックスを用いた神経活動依存的なAβ分泌・蓄積の検討2012
- Author(s)
  山本薫、奥野浩行、尾藤晴彦、若林朋子、橋本唯史、岩坪威
- Organizer
  第３１回　日本認知症学会
- Place of Presentation
  筑波市
- Invited
- Data Source
  KAKENHI-PLANNED-22110003
[Presentation] Remodeling of the morphology of beta-amyloid plaques by CLAC in the brains of transgenic mice2012
- Author(s)
  Tadafumi Hashimoto, Daisuke Fujii, Mayu Kashiwagi, Yuko Matsuo, Yusuke Matsura, Tomoko Sakakura, Hisatomo Kowa, David Westaway, Tomoko Wakabayashi, and Takeshi Iwatsubo
- Organizer
  Society for Neuroscience
- Place of Presentation
  New Oreleans, USA.
- Year and Date
  2012-10-15
- Data Source
  KAKENHI-PROJECT-24800015
[Presentation] Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid beta peptide. Gordon Research Conferences, Neurobiology of brain disorders2012
- Author(s)
  Tadafumi Hashimoto, Alberto Serrano-Pozo, Yukiko Hori, Hwan-Ching Tai, Kenneth W Adams, Shuko Takeda, Daniel Joyner, Diana H Thyssen, Brian J Bacskai, Matthew P Frosch, Tara L Spires-Jones, Mary Beth Finn, David M Holtzman, and Bradley T Hyman
- Organizer
  Neurobiology of brain disorders
- Place of Presentation
  Easton, USA.
- Data Source
  KAKENHI-PROJECT-24800015
[Presentation] Isoform-specific effects of apolipoprotein E on the stability of Aβ protofibrils2007
- Author(s)
  Hashimoto T
- Organizer
  37th society for neuroscience
- Place of Presentation
  San Diego
- Year and Date
  2007-11-04
- Data Source
  KAKENHI-PROJECT-19790050
[Presentation] Amyloid β aggregation: role of interactor proteins2007
- Author(s)
  Hashimoto T
- Organizer
  IBRO 2007
- Place of Presentation
  Melbourne
- Year and Date
  2007-07-15
- Data Source
  KAKENHI-PROJECT-19790050
[Presentation] Two distinct pathways leading to degeneration in transgenic Drosophila melanogaster overexpressing human FUS
- Author(s)
  Hashimoto T, Kunugi H, Matsukawa K, Uchigami H, Ihara R, Chihara T, Miura M, Wakabayashi T, Iwatsubo T
- Organizer
  Alzheimer's Association International Conference
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-24800015

1. IWATSUBO Takeshi (50223409)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
2. WAKABAYASHI Tomoko (20530330)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. ITO Genta (10431892)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 山田薫 (00735152)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 高杉展正 (60436590)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. IWATA Atsushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 佐藤隆史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 倉永英里奈

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 千原崇裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
10. 尾藤晴彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 山本亘彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 橋本亮太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 饗場篤

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 玉岡晃

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 長谷川成人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 高橋隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 岩田孝吉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 村山繁雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 堀由起子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hashimoto Tadafumi 橋本 唯史

HASHIMOTO Tadafumi 橋本 唯史

Research Projects

Research Products

Co-Researchers

Elucidation of physiological and pathological roles of TDP-43 through autophagic machineryPrincipal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ALS病因タンパク質FUSの細胞間伝播及び神経細胞障害性発揮メカニズムの解明Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

アルツハイマー病Aβの脳内エコノミー破綻によるタウ依存的神経障害の分子基盤解明Ongoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

アルツハイマー病発症機構における脂質フリッパーゼの役割の解析と予防・治療法の開発Ongoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the pathomechanism of neurodegeneration induced by TDP-43Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study for the metabolism and neurotoxicity of amyloid beta peptide oligomersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the molecular pathology of Alzheimer's disease focusing on the synapses toward therapies

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

アルツハイマー病脳におけるアミロイド構成蛋白質CLACに関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

アルツハイマー病新規アミロイド構成蛋白質CLACに関する病態生化学的研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular and cell biological studies on the production, aggregation and clearance of Alzheimer amyloid β peptides.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

アルツハイマー病脳老人斑アミロイドを構成する新規タンパク質CLACに関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Self-assembly of FUS through its low-complexity domain contributes to neurodegeneration2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Soluble oligomeric amyloid-beta induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain2017

Author(s)

Journal Title

DOI

Hashimoto Tadafumi 橋本唯史

HASHIMOTO Tadafumi 橋本唯史