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Okazawa Hitoshi  岡澤 均

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OKAZAWA Hitoshi  岡澤 均

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Researcher Number 50261996
Other IDs
Affiliation (Current) 2022: 東京医科歯科大学, 難治疾患研究所, 教授
Affiliation (based on the past Project Information) *help 2003 – 2022: Tokyo Medical and Dental University, Medical Research institute, Professor, 難治疾患研究所, 教授
2002: 財団法人東京都医学研究機構, 東京都神経科学総合研究所, 副参事研究員
1998 – 2001: 東京大学, 医学部・附属病院, 助手
1996: UNIVERSITY OF TOKYO,DEPARTMENT OF NEUROLOGY,ASSISTANT PROFESSOR, 医学部・附属病院, 助手
1995: 東京大学, 医学部(医), 助手
Review Section/Research Field
Principal Investigator
Biological Sciences / Neurology / Neurology / Nerve anatomy/Neuropathology / Medium-sized Section 52:General internal medicine and related fields / Neurochemistry/Neuropharmacology / Neurochemistry/Neuropharmacology
Except Principal Investigator
Neuroscience in general / Biological Sciences / Basic / Social brain science / Basic Section 57070:Developmental dentistry-related
Keywords
Principal Investigator
神経変性 / ポリグルタミン / 転写 / 細胞死 / ハンチントン病 / PQBP1 / ポリグルタミン病 / HMGB / 治療 / スプライシング … More / PQBP-1 / 神経 / YAP / 神経細胞死 / プロテオーム / ショウジョウバエ / 小頭症 / 発達障害 / 神経変性疾患 / neuron / polyglutamine / transcription / 変性 / アポトーシス / 脊髄小脳変性症 / 精神遅滞 / DNA損傷修復 / シナプス / 病態 / 神経回路 / 分子病態 / 分子イメージング / アルツハイマー病 / 遺伝子治療 / 神経細胞 / 転写因子 / POU / transcription factor / cell death / 核機能 / hsp70 / TRIAD / ネクローシス / p73 / 核 / ストレス / シグナル / DNA修復 / ジェノトキシックストレス / プロテオミクス / モデルマウス / RNAi / マウスモデル / DNA2重鎖切断 / ハンチンチン / Ku70 / インタラクトーム / トランスジェニックマウス / 核タンパク / 脳サイズ / 細胞周期 / 神経幹細胞 / ノックアウトマウス / 神経分子病態学 / ハイスループット / スクリーニング / 治療薬 / 動物モデル / マウス / 治療薬スクリーニング / 脊髄小脳失調症1型 / 変性疾患 / 精神疾患 / 分子 / サーキット / ニューロサーキット / パソロジー / 幹細胞 / PQBP１ / VCP / 微小管 / TERA / スプライシング異常 / 構造生物学 / 知的障害 / AIDS / HIV / 冠動脈疾患 / 天然変性タンパク質 / RNA / 機能障害 / 特異性 / ドパミン受容体 / 発現制御 / POU転写因子 / ニューロン / 分化 / 発現調節 / specificity / dopamine receptor / gene therapy / トリプレットリピート病 / 神経特異的転写因子 / 転写補助因子 / triplet repeat diseases / neuronal death / U5-15kD / スプライミング / spinocerebellar degeneration / RNA polymerase II / POLYGLUTAMINE DISEASES / MEURODEGENTATION / TRANSCRIPTION / NUCLEARFUNCTION / RNA POLYMERASE II / トランスクリプトーム / 転写障害 / Hsp70 / ペプチド / BrU / proteome / transcriptome / neurodegeneration / 脊髓小脳変性症 / DNA損傷 / POLYGLUTAMINE / therapeutics / spinocerebellar ataxia / Huntington's disease / DNA repair / Hippo pathway / hnRNP / Hippo / 脳神経疾患 / 変性拡散仮説 / 死細胞・生細胞間シグナル伝達 / 認知症 / HMGB1 … More
Except Principal Investigator
アルツハイマー病 / ショウジョウバエ / 神経変性 / 神経変性疾患 / 認知症 / 細胞内タンパク質輸送 / モデル動物 / 細胞内輸送 / トラフィッキング / 脳・神経 / タウ蛋白 / 神経原線維変化 / 神経細胞死 / Alzheimer's disease / Tau / Neurofibrillary tangles / Neuronal death / 脳科学 / 研究支援 / 研究集会 / 研究リソース / 技術開発 / 若手研究者育成支援 / 研究リソース支援 / 技術開発支援 / ブレインバンク / 脳画像データベース / 脳分子プロファイル / ウイルスベクター / シナプス / 小胞輸送 / PQBP1 / 骨代謝 / 小頭症マウス / 骨代謝メカニズム / AAV 遺伝子導入治療 / 歯科矯正治療 Less

  • Research Projects

    (25 results)

  • Research Products

    (649 results)

  • Co-Researchers

    (204 People)

  •  脳老化・神経変性の連続性・非連続性の分子計算論的解明と予防医療への応用Principal Investigator

    • Principal Investigator
      岡澤 均
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 52:General internal medicine and related fields
    • Research Institution
      Tokyo Medical and Dental University

  •  骨髄ニッチにおけるPqbp1の意義とPQBP1異常小頭症の医科歯科連携遺伝子治療

    • Principal Investigator
      石田 宝義
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57070:Developmental dentistry-related
    • Research Institution
      Tokyo Medical and Dental University

  •  Establishment of neurodegeneration-expansion by death cell-live cell signal transduction and development of new therapeutics targeting on the signalPrincipal Investigator

    • Principal Investigator
      岡澤 均
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 52:General internal medicine and related fields
    • Research Institution
      Tokyo Medical and Dental University

  •  Integrative understanding and therapeutic application of seamless degenerative processes based on Hippo pathwayPrincipal Investigator

    • Principal Investigator
      Okazawa Hitoshi
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Neurology
    • Research Institution
      Tokyo Medical and Dental University

  •  Therapeutics development against intellectual disability via structural biology analysesPrincipal Investigator

    • Principal Investigator
      Okazawa Hitoshi
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Tokyo Medical and Dental University

  •  Elucidating the molecular mechanisms of neurodegeneration by genetic studies focused on the mechanisms of intracellular protein trafficking

    • Principal Investigator
      SONE Masaki
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Basic / Social brain science
    • Research Institution
      Toho University

  •  Mechanisms of neurodegeneration caused by impaired intracellular protein trafficking

    • Principal Investigator
      SONE Masaki
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neuroscience in general
    • Research Institution
      Toho University

  •  Foundation of Synapse and Neurocircuit PathologyPrincipal Investigator

    • Principal Investigator
      OKAZAWA Hitoshi
    • Project Period (FY)
      2010 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University

  •  Elucidation of dynamic pathologies of developmental and neurodegenerative diseasesPrincipal Investigator

    • Principal Investigator
      OKAZAWA Hitoshi
    • Project Period (FY)
      2010 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University

  •  Generation of synapse-neurocircuit pathologyArea Organizer

    • Area Organizer
      OKAZAWA Hitoshi
    • Project Period (FY)
      2010 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Research Institution
      Tokyo Medical and Dental University

  •  Comprehensive Brain Science Network

    • Principal Investigator
      Kimura Minoru
    • Project Period (FY)
      2010 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Research Institution
      Center for Novel Science Initatives, National Institutes of Natural Sciences

  •  Drug development for polyglutamine diseases by a combined phenotype analysis systemPrincipal Investigator

    • Principal Investigator
      OKAZAWA Hitoshi
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      Tokyo Medical and Dental University

  •  ポリグルタミン病態における核ストレスの解析と治療応用Principal Investigator

    • Principal Investigator
      岡澤 均
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University

  •  神経幹細胞の細胞周期制御によるブレインサイズ決定機構の解析Principal Investigator

    • Principal Investigator
      岡澤 均
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University

  •  ポリグルタミン病態における核ストレスの解析と治療応用Principal Investigator

    • Principal Investigator
      岡澤 均
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University

  •  PQBP1遺伝子変異による精神遅滞のモデルマウス作成と解析Principal Investigator

    • Principal Investigator
      岡澤 均
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      Tokyo Medical and Dental University

  •  Basic Research for Development of the Polyglutamine Disease Therapeutics by HMGB proteinsPrincipal Investigator

    • Principal Investigator
      OKAZAWA Hitoshi
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      Tokyo Medical and Dental University

  •  ポリグルタミン病態における核ストレスの解析と治療応用Principal Investigator

    • Principal Investigator
      岡澤 均
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University

  •  転写障害による神経細胞死の分子的定義の研究Principal Investigator

    • Principal Investigator
      岡澤 均
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      Tokyo Medical and Dental University

  •  Basic Research for Development of Novel Therapeutics of Polyglutamine Diseases through Transcriptional RegulationPrincipal Investigator

    • Principal Investigator
      OKAZAWA Hitoshi
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      TOKYO MEDICAL AND DENTAL UNIVERSITY

  •  Functional and dynamic gene expression profiling of polyglutaminePrincipal Investigator

    • Principal Investigator
      OKAZAWA Hitoshi
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      Tokyo Medical and Dental University
      Tokyo Metropolitan Organization for Medical Research

  •  Hyperphosphorylation and aggregation of tau protein, and neuronal death

    • Principal Investigator
      IHARA Yasuo
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      University of Tokyo

  •  Physiological and pathological functions of PQBP-1Principal Investigator

    • Principal Investigator
      OKAZAWA Hitoshi
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      The University of Tokyo

  •  Analysis on interaction between triplet repeat disease gene products and neuron-specific transcription-related factorsPrincipal Investigator

    • Principal Investigator
      OKAZAWA Hitoshi
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      The University of Tokyo

  •  NEURONAL TRANSFORMATION BY INDUCING NEURON-SPECIFIC TRANSCRIPTION FACTORS.Principal Investigator

    • Principal Investigator
      OKAZAWA Hitoshi
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      UNIVERSITY OF TOKYO

All 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Other

All Journal Article Presentation Book Patent

  • [Book] 脳疾患のバイオマーカーとオプトジェネティクス2012
    • Author(s)
      岡澤均
    • Total Pages
      128
    • Publisher
      実験医学
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Book] ハンチントン病の分子病態解明2011
    • Author(s)
      岡澤均
    • Publisher
      臨床神経学
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Book] ハンチントン病の分子病態解明2011
    • Author(s)
      岡澤均
    • Publisher
      臨床神経学
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Book] ポリグルタミン病における凝集毒性概念の変遷と治療2011
    • Author(s)
      岡澤均
    • Publisher
      日本認知症学会誌
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Book] はじめに、精神発達遅滞・自閉症の分子医学2011
    • Author(s)
      岡澤均
    • Publisher
      医学のあゆみ
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Book] けじめに、精神発達遅滞・自閉症の分子医学2011
    • Author(s)
      岡澤均
    • Publisher
      医学のあゆみ
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Book] ポリグルタミン病における凝集毒性概念の変遷と治療2011
    • Author(s)
      岡澤均
    • Publisher
      日本認知症学会誌
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Book] DNA損傷修復からみた神経変性機序2011
    • Author(s)
      岡澤均
    • Publisher
      臨床神経学
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Book] DNA損傷修復からみた神経変性機序2011
    • Author(s)
      岡澤均
    • Publisher
      臨床神経学
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Book] ハンチントン病の分子病態解明2011
    • Author(s)
      岡澤均
    • Publisher
      臨床神経学
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Book] はじめに、精神発達遅滞・自閉症の分子医学2011
    • Author(s)
      岡澤均
    • Publisher
      医学のあゆみ
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Book] ポリグルタミン病における凝集毒性概念の変遷と治療2011
    • Author(s)
      岡澤均
    • Publisher
      日本認知症学会誌
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Book] DNA損傷修復からみた神経変性機序2011
    • Author(s)
      岡澤均
    • Publisher
      臨床神経学
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Book] "POLYGLUTAMINE DISEASES" in Handbook of Neurochemistry and Molecular Neurobiology: Neural Protein Metabolism and Function, Edited by A Lajtha,2007
    • Author(s)
      Okazawa H.
    • Total Pages
      736
    • Publisher
      Springer (ISBN 9780387303468)
    • Data Source
      KAKENHI-PROJECT-18390254

  • [Book] POLYGLUTAMINE DISEASES in Handbook of Neurochemistry and Molecular Neurobiology: Neural Protein Metabolism and Function, Edited by A Lajtha2007
    • Author(s)
      Okazawa H.
    • Total Pages
      736
    • Publisher
      Springer (ISBN 9780387303468)
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390254

  • [Book] POLYGLUTAMINE DISEASES in Handbook of Neurochemistry and Molecular Neurobiology: Neural Protein Metabolism and Function, Edited by A Lajtha,2007
    • Author(s)
      Okazawa H.
    • Total Pages
      736
    • Publisher
      Springer (ISBN 9780387303468)
    • Data Source
      KAKENHI-PROJECT-18023014

  • [Book] POLYGLUTAMINE DISEASES" in Handbook of Neurochemistry and Molecular Neurobiology: Neural Protein Metabolism and Function, Edited by A Lajtha,2007
    • Author(s)
      Okazawa H.
    • Total Pages
      736
    • Publisher
      Springer (ISBN 9780387303468)
    • Data Source
      KAKENHI-PROJECT-18650097

  • [Book] Protein Misfolding, Aggregation and Conformational Diseases2006
    • Author(s)
      OKAZAWA H.
    • Total Pages
      5
    • Publisher
      Academic/Plenum Press
    • Data Source
      KAKENHI-PROJECT-17025017

  • [Book] Protein Misfolding, Aggregation and Conformational Diseases2006
    • Author(s)
      OKAZAWA H.
    • Total Pages
      5
    • Publisher
      Academic/Plenum Press
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390249

  • [Book] Protein Misfolding, Aggregation and Conformational Diseases2006
    • Author(s)
      OKAZAWA H.
    • Total Pages
      5
    • Publisher
      Academic/Plenum Press
    • Data Source
      KAKENHI-PROJECT-16650076

  • [Book] Glutamine and Asparagine-rich Sequences and Polyglutamine Diseases. In Protein Reviews, Volume 6, Protein Misfolding, Aggregation, and Conformational Diseases. edited by Vladimir N, Uverskyand・AnthonyFinkr N, Uversky and Anthony Fink2006
    • Author(s)
      Okazawa H.
    • Total Pages
      537
    • Publisher
      Springer (ISBN 9780387365299)
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390254

  • [Book] POLYGLUTAMINEDISEASES in Handbook of Neurochemistry and Molecular Neurobiology : Neural Protein Metabolism and Function
    • Author(s)
      Okazawa, H.
    • Publisher
      Edited by A Lajtha, Springer
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Journal Article] Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (4th edition)2021
    • Author(s)
      Daniel J Klionsky、Shu Aizawa、Amal Kamal Abdel-Aziz、Sara Abdelfatah、Mahmoud Abdellatif、Asghar Abdoli、Steffen Abel、Hagai Abeliovich、Marie H Abildgaard、Yakubu Princely Abudu、Abraham Acevedo-Arozena、Iannis E Adamopoulos、Khosrow Adeli、Timon E Adolph、Annagrazia Adornetto、Elma Aflaki、Galila Agam et al.
    • Journal Title

      Autophagy

      Volume: 17 Pages: 1-382

    • DOI

      10.1080/15548627.2020.1797280

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06375, KAKENHI-PROJECT-19K07568, KAKENHI-PROJECT-19K08851, KAKENHI-PROJECT-20K06501, KAKENHI-PROJECT-20K06636, KAKENHI-PROJECT-20K07896, KAKENHI-PROJECT-20K21769, KAKENHI-PROJECT-18H02901, KAKENHI-PLANNED-20H05772, KAKENHI-PROJECT-19H01042, KAKENHI-PROJECT-18H02439, KAKENHI-PROJECT-18H02656, KAKENHI-PROJECT-18H02807, KAKENHI-PROJECT-20J00363, KAKENHI-PROJECT-18K06210, KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-18K08079, KAKENHI-PROJECT-18K09427

  • [Journal Article] Role of the <i>Drosophila</i> YATA protein in the proper subcellular localization of COPI revealed by <i>in vivo</i> analysis2021
    • Author(s)
      Saito Maiko、Nakayama Minoru、Fujita Kyota、Uchida Atsuko、Yano Hiroyuki、Goto Satoshi、Okazawa Hitoshi、Sone Masaki
    • Journal Title

      Genes Genet. Syst.

      Volume: 95 Issue: 6 Pages: 303-314

    • DOI

      10.1266/ggs.20-00027

    • NAID

      130008002033

    • ISSN
      1341-7568, 1880-5779
    • Language
      English
    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K06881, KAKENHI-PROJECT-19H01042

  • [Journal Article] ポストコロナ社会における脳神経疾患の診療と研究2020
    • Author(s)
      岡澤 均
    • Journal Title

      脳神経疾患克服に向けた研究推進の提言2020

      Volume: - Pages: 17-17

    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Journal Article] アルツハイマー病態に於ける細胞内アミロイド、細胞死、細胞外アミロイド凝縮の時間的関係2020
    • Author(s)
      岡澤 均
    • Journal Title

      神経治療学

      Volume: 37

    • NAID

      130007922492

    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Journal Article] 脊髄小脳失調症2020
    • Author(s)
      田中　ひかり、岡澤　均
    • Journal Title

      Clinical Neuroscience

      Volume: 38 Pages: 365-368

    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Journal Article] PQBP1, an intellectual disability causative gene, affects bone development and growth2020
    • Author(s)
      Yang Shin-Sheng、Ishida Takayoshi、Fujita Kyota、Nakai Yuta、Ono Takashi、Okazawa Hitoshi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 523 Pages: 894-899

    • DOI

      10.1016/j.bbrc.2019.12.097

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H01042, KAKENHI-PROJECT-19K10378

  • [Journal Article] ダウンストリームを治療する2020
    • Author(s)
      田中 ひかり、岡澤 均
    • Journal Title

      医学のあゆみ

      Volume: 273 Pages: 93-97

    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Journal Article] YAP-dependent necrosis occurs in early stages of Alzheimer's disease and regulates mouse model pathology.2020
    • Author(s)
      Tanaka Hikari, Tagawa Kazuhiko, Okazawa Hitoshi et al.
    • Journal Title

      Nature Communications

      Volume: 11 Pages: 1-22

    • DOI

      10.1038/s41467-020-14353-6

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07817, KAKENHI-PROJECT-18K14840, KAKENHI-PROJECT-19H01042, KAKENHI-PROJECT-17K09318, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-20H03587

  • [Journal Article] Chronic cerebral hypoperfusion shifts the equilibrium of amyloid beta oligomers to aggregation-prone species with higher molecular weight2019
    • Author(s)
      Bannai Taro、Mano Tatsuo、Chen Xigui、Ohtomo Gaku、Ohtomo Ryo、Tsuchida Takeyuki、Koshi-Mano Kagari、Hashimoto Tadafumi、Okazawa Hitoshi、Iwatsubo Takeshi、Tsuji Shoji、Toda Tatsushi、Iwata Atsushi
    • Journal Title

      Scientific Reports

      Volume: 9 Pages: 1-11

    • DOI

      10.1038/s41598-019-39494-7

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07364, KAKENHI-PUBLICLY-17H05687, KAKENHI-PROJECT-16H05319, KAKENHI-PROJECT-17K16113, KAKENHI-PROJECT-16H02655, KAKENHI-PROJECT-17H04193

  • [Journal Article] 発達障害原因遺伝子PQBP1はアルツハイマー病態を制御する2019
    • Author(s)
      田中　ひかり、岡澤　均
    • Journal Title

      ケミカルバイオロジー

      Volume: 12 Pages: 12-12

    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Journal Article] Methods to Image Macroautophagy in the Brain In Vivo2019
    • Author(s)
      Chen Xigui、Kondo Kanoh、Okazawa Hitoshi
    • Journal Title

      Methods in Molecular Biology

      Volume: 1880 Pages: 529-534

    • DOI

      10.1007/978-1-4939-8873-0_33

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Journal Article] Drebrin-like (Dbnl) Controls Neuronal Migration via Regulating N-Cadherin Expression in the Developing Cerebral Cortex.2019
    • Author(s)
      Inoue Seika、Hayashi Kanehiro、Fujita Kyota、Tagawa Kazuhiko、Okazawa Hitoshi、Kubo Ken-ichiro、Nakajima Kazunori
    • Journal Title

      J Neurosci.

      Volume: 39 Pages: 678-691

    • DOI

      10.1523/jneurosci.1634-18.2018

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06842, KAKENHI-PROJECT-18K07855, KAKENHI-PROJECT-18K19379, KAKENHI-PROJECT-15H02355, KAKENHI-PROJECT-16K07040, KAKENHI-PROJECT-16H02655, KAKENHI-PLANNED-16H06482

  • [Journal Article] Frameshift PQBP-1 mutants K192Sfs*7 and R153Sfs*41 implicated in X-linked intellectual disability form stable dimers2019
    • Author(s)
      Rahman Shah Kamranur、Okazawa Hitoshi、Chen Yu Wai
    • Journal Title

      Journal of Structural Biology

      Volume: 206 Pages: 305-313

    • DOI

      10.1016/j.jsb.2019.04.003

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Journal Article] 脊髄小脳失調症とYAPdeltaC2019
    • Author(s)
      近藤 和, 藤田 慶大, 岡澤 均
    • Journal Title

      Clinical Neuroscience

      Volume: 37 Pages: 1007-1010

    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Journal Article] 変性疾患におけるシナプス異常の新知見2018
    • Author(s)
      岡澤　均、藤田　慶大
    • Journal Title

      月刊細胞(2018年12月号）

      Volume: 50 Pages: 25-28

    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Journal Article] Suppression of the synaptic localization of a subset of proteins including APP partially ameliorates phenotypes of the Drosophila Alzheimer's disease model2018
    • Author(s)
      Furotani Koto、Kamimura Keisuke、Yajima Takaaki、Nakayama Minoru、Enomoto Rena、Tamura Takuya、Okazawa Hitoshi、Sone Masaki
    • Journal Title

      PLOS ONE

      Volume: 13

    • DOI

      10.1371/journal.pone.0204048

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K07077, KAKENHI-PROJECT-16H02655

  • [Journal Article] Mild maternal hypothyroxinemia during pregnancy induces persistent DNA hypermethylation in the hippocampal brain-derived neurotrophic factor gene in mouse offspring.2018
    • Author(s)
      Kawahori K, Hashimoto K, Yuan X, Tsujimoto K, Hanzawa N, Hamaguchi M, Kase S, Fujita K, Tagawa K, Okazawa H, Nakajima Y, Shibusawa N, Yamada M, Ogawa Y
    • Journal Title

      Thyroid

      Volume: 28 Pages: 395-406

    • DOI

      10.1089/thy.2017.0331

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K01840, KAKENHI-PUBLICLY-16H01354, KAKENHI-PROJECT-16H02655, KAKENHI-PROJECT-16H05331, KAKENHI-PROJECT-17H06652

  • [Journal Article] 総論 シナプス研究を加速する基礎臨床連携2018
    • Author(s)
      岡澤　均
    • Journal Title

      月刊細胞(2018年12月号）

      Volume: 50 Pages: 2-4

    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Journal Article] The Relationship between Neurite Density Measured with Confocal Microscopy in a Cleared Mouse Brain and Metrics Obtained from Diffusion Tensor and Diffusion Kurtosis Imaging2018
    • Author(s)
      Irie R., Kamagata K., Kerever A., Ueda R., Yokosawa S., Otake Y., Ochi H., Yoshizawa H., Hayashi A., Tagawa K., Okazawa H., Takahashi K., Sato K., Hori M., Arikawa-Hirasawa E., Aoki S.
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 17 Issue: 2 Pages: 128-144

    • DOI

      10.2463/mrms.mp.2017-0031

    • NAID

      130006685597

    • ISSN
      1347-3182, 1880-2206
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H02655, KAKENHI-PROJECT-17H07097, KAKENHI-PROJECT-16H06280, KAKENHI-PROJECT-18H02772

  • [Journal Article] 第3節　 凝集前病態の解明に基づくアルツハイマー病の新規DMT 開発2018
    • Author(s)
      藤田　慶大、 岡澤　均
    • Journal Title

      アルツハイマー病 ～発症メカニズムと新規診断法・創薬・治療開発～

      Volume: - Pages: 157-164

    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Journal Article] Ser46-Phosphorylated MARCKS Is a Marker of Neurite Degeneration at the Pre-aggregation Stage in PD/DLB Pathology2018
    • Author(s)
      Fujita Kyota、Homma Hidenori、Kondo Kanoh、Ikuno Masashi、Yamakado Hodaka、Tagawa Kazuhiko、Murayama Shigeo、Takahashi Ryosuke、Okazawa Hitoshi
    • Journal Title

      eneuro

      Volume: 5 Pages: 0217-18

    • DOI

      10.1523/eneuro.0217-18.2018

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-17H05698, KAKENHI-PROJECT-16K07040, KAKENHI-PROJECT-16H02655

  • [Journal Article] ハンチントン病2018
    • Author(s)
      岡澤　均、本間　秀典
    • Journal Title

      Clinical Neuroscience Vol.36 No.2

      Volume: 36 Pages: 213-215

    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Journal Article] TRIAD(Transcriptional Repression-Induced Atypical Death)2018
    • Author(s)
      Takuya Tamura、Hitoshi Okazawa
    • Journal Title

      Apoptosis and Beyond :The Many Ways Cells Die

      Volume: 2 Pages: 411-426

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Journal Article] Targeting tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology.2018
    • Author(s)
      Fujita K, Chen X, Homma H, Tagawa K, Amano M, Saito A, Imoto S, Akatsu H, Hashizume Y, Kaibuchi K, Miyano S, Okazawa H.
    • Journal Title

      Nat Commun.

      Volume: 9 Issue: 1 Pages: 433-433

    • DOI

      10.1038/s41467-018-02821-z

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K07383, KAKENHI-PROJECT-17K08725, KAKENHI-PLANNED-15H05912, KAKENHI-PUBLICLY-17H05561, KAKENHI-PUBLICLY-17H05693, KAKENHI-PROJECT-16H02655, KAKENHI-PROJECT-16H06277

  • [Journal Article] Bridging Multiple Dementias2018
    • Author(s)
      Okazawa Hitoshi
    • Journal Title

      ACS Chemical Neuroscience

      Volume: 9 Pages: 636-638

    • DOI

      10.1021/acschemneuro.8b00119

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Journal Article] The intellectual disability gene PQBP1 rescues Alzheimer’s disease pathology2018
    • Author(s)
      Tanaka Hikari、Kondo Kanoh、Chen Xigui、Homma Hidenori、Tagawa Kazuhiko、Kerever Aurelien、Aoki Shigeki、Saito Takashi、Saido Takaomi、Muramatsu Shin-ichi、Fujita Kyota、Okazawa Hitoshi
    • Journal Title

      Molecular Psychiatry

      Volume: 23 Pages: 2090-2110

    • DOI

      10.1038/s41380-018-0253-8

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H07097, KAKENHI-PROJECT-16K07040, KAKENHI-PROJECT-16H02655

  • [Journal Article] 特集 遺伝性脊髄小脳失調症の病態と治療展望 HMGB1補充による脊髄小脳失調症1型に対する分子標的治療2017
    • Author(s)
      藤田 慶大、岡澤 均
    • Journal Title

      BRAIN and NERVE

      Volume: 69 Issue: 8 Pages: 925-932

    • DOI

      10.11477/mf.1416200844

    • ISSN
      1344-8129, 1881-6096
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Journal Article] Developmental YAPdeltaC determines adult pathology in a model of spinocerebellar ataxia type 12017
    • Author(s)
      Fujita K, Mao Y, Uchida S, Chen X, Shiwaku H, Tamura T, Ito H, Watase K, Homma H, Tagawa K, Sudol M, Okazawa H.
    • Journal Title

      Nature Communications

      Volume: 8 Pages: 1864-1864

    • DOI

      10.1038/s41467-017-01790-z

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K16367, KAKENHI-PROJECT-16H02655, KAKENHI-PROJECT-16H07001

  • [Journal Article] Understanding microstructure of the brain by comparison of neurite orientation dispersion and density imaging (NODDI) with transparent mouse brain2017
    • Author(s)
      Sato K., Kerever A., Kamagata K., Tsuruta K., Irie R., Tagawa K., Okazawa H., Arikawa-Hirasawa E., Nitta N., Aoki I., Aoki S.
    • Journal Title

      Acta Radiol Open

      Volume: 6 Pages: 1-6

    • DOI

      10.1177/2058460117703816

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K19853, KAKENHI-PROJECT-16H02655, KAKENHI-PROJECT-16H06280

  • [Journal Article] Ultra-Early Phase pathologies of Alzheimer’s disease and other neurodegenerative diseases2017
    • Author(s)
      Okazawa Hitoshi
    • Journal Title

      Proc. Jpn. Acad., Ser. B

      Volume: 93 Issue: 6 Pages: 361-377

    • DOI

      10.2183/pjab.93.022

    • NAID

      130005696850

    • ISSN
      0386-2208, 1349-2896
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Journal Article] 発症分子機構update 3.アミロイド凝集前の超早期病態とその抑制2017
    • Author(s)
      岡澤 均、藤田 慶大
    • Journal Title

      実験医学増刊　vol.35 No.12

      Volume: 35 Pages: 198-203

    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Journal Article] A novel form of necrosis, TRIAD, occurs in human Huntington's disease2017
    • Author(s)
      Yamanishi, E., Hasegawa, K., Fujita, K., Ichinose, S., Yagishita, S., Murata, M., Tagawa, K., Akashi, T., Eishi, Y., Okazawa, H.
    • Journal Title

      Acta Neuropathologica Communications

      Volume: 5

    • DOI

      10.1186/s40478-017-0420-1

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Journal Article] PQBP1, an intrinsically disordered/denatured protein at the crossroad of intellectual disability and neurodegenerative diseases2017
    • Author(s)
      Okazawa Hitoshi
    • Journal Title

      Neurochemistry International

      Volume: 印刷中

    • DOI

      10.1016/j.neuint.2017.06.005

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Journal Article] 「アルツハイマー病の“超早期”治療を可能にする分子メカニズムと治療薬開発」2016
    • Author(s)
      岡澤　均
    • Journal Title

      月刊ファームステージ 2016.12月号

      Volume: 16 Pages: 39-45

    • NAID

      40021030556

    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Journal Article] 「特集　「認知症・神経変性疾患の克服への挑戦」によせて」2016
    • Author(s)
      岡澤　均
    • Journal Title

      生体の科学

      Volume: 67 Pages: 280-280

    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Journal Article] HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer’s disease2016
    • Author(s)
      Fujita, K., Motoki, K., Tagawa, K., Chen, X., Hama, H., Nakajima, K., Homma, H., Tamura, T., Watanabe, H., Katsuno, M., Matsumi, C., Kajikawa, M., Saito, T., Saido, T., Sobue, G., Miyawaki, A., Okazawa, H.
    • Journal Title

      Scientific Reports.

      Volume: 6 Pages: 31895-31895

    • DOI

      10.1038/srep31895

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02655, KAKENHI-PROJECT-26290019, KAKENHI-PROJECT-15K15338, KAKENHI-PROJECT-16K07040

  • [Journal Article] RpA1 ameliorates symptoms of mutant Ataxin-1 knock-in mice and enhances DNA damage repair.2016
    • Author(s)
      Taniguchi, JB., Kondo, K., Fujita, K., Chen, X., Homma, H., Sudo, T., Mao, Y., Watase, K., Tanaka, T., Tagawa, K., Tamura, T., Muramatsu, SI., Okazawa, H.
    • Journal Title

      Hum Mol Genet

      Volume: 25 Pages: 4432-4447

    • DOI

      10.1093/hmg/ddw272

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H02655, KAKENHI-PROJECT-25282241, KAKENHI-PROJECT-26293213

  • [Journal Article] Allosteric modulation of the binding affinity between PQBP1 and the spliceosomal protein U5-15kD.2016
    • Author(s)
      Mizuguchi, M., Obita, T., Kajiyama, A., Kozakai, Y., Nakai, T., Nabeshima, Y., Okazawa, H.
    • Journal Title

      FEBS Lett

      Volume: 590 Pages: 2221-2231

    • DOI

      10.1002/1873-3468.12256

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-16H02655, KAKENHI-PROJECT-15K07886, KAKENHI-PROJECT-16K07265

  • [Journal Article] 「変性疾患の共通分子病態」2016
    • Author(s)
      藤田　慶大、岡澤　均
    • Journal Title

      生体の科学

      Volume: 67 Pages: 309-313

    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Journal Article] The hnRNP-Htt axis regulates necrotic cell death induced by transcriptional repression through impaired RNA splicing2016
    • Author(s)
      Y. Mao, T. Tamura, Y. Yuki, D. Abe, Y. Tamada, S. Imoto, H. Tanaka, H. Homma, K. Tagawa, S. Miyano and H. Okazawa
    • Journal Title

      Cell Death and Disease

      Volume: 7

    • DOI

      10.1038/cddis.2016.101

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K20965, KAKENHI-PROJECT-16H02655

  • [Journal Article] Quantitative Histological Validation of Diffusion Tensor MRI with Two-Photon Microscopy of Cleared Mouse Brain2016
    • Author(s)
      Kamagata, K., Kerever, A., Yokosawa, S., Otake, Y., Ochi, H., Hori, M., Kamiya, K., Tsuruta, K., Tagawa, K., Okazawa, H., Aoki, S., Arikawa-Hirasawa, E.
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 印刷中(Epub ahead of print) Issue: 4 Pages: 416-421

    • DOI

      10.2463/mrms.bc.2015-0148

    • NAID

      130005421023

    • ISSN
      1347-3182, 1880-2206
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26640037

  • [Journal Article] 神経疾患におけるリン酸化シグナルの網羅的解析2016
    • Author(s)
      田川 一彦、本間 秀典、岡澤 均
    • Journal Title

      Clinical Neuroscience.

      Volume: 34 Pages: 119-120

    • Data Source
      KAKENHI-PROJECT-26640037

  • [Journal Article] 「1990年以後の神経栄養因子臨床試験からの知見と教訓」2016
    • Author(s)
      岡澤　均、本木　和美
    • Journal Title

      生体の科学

      Volume: 67 Pages: 291-295

    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Journal Article] Identification of hepta-histidine as a candidate drug for Huntington’s disease by in silico-in vitro-in vivo-integrated screens of chemical libraries2016
    • Author(s)
      Imamura, T., Fujita, K., Tagawa, K., Ikura, T., Chen, X., Homma, H., Tamura, T., Mao, Y., Taniguchi, JB., Motoki, K., Nakabayashi, M., Ito, N., Yamada, K., Tomii, K., Okano, H., Kaye, J., Finkbeiner, S., Okazawa, H.
    • Journal Title

      Scientific Reports

      Volume: 6

    • DOI

      10.1038/srep33861

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Journal Article] Targeting TEAD/YAP-transcription-dependent necrosis, TRIAD, ameliorates Huntington’s disease pathology2016
    • Author(s)
      Mao, Y., Chen, X., Xu, M.,Fujita, K., Sasabe, K.,Homma, H., Murata, M., Tagawa, K., Tamura, T., Kaye, J., Finkbeiner, S., Blandino, G., Sudol, M., Okazawa, H.
    • Journal Title

      Human Molecular Genetics

      Volume: 25 Pages: 4749-4770

    • DOI

      10.1093/hmg/ddw303

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Journal Article] Impaired DNA damage repair as a common feature of neurodegenerative diseases and psychiatric disorders.2015
    • Author(s)
      Shiwaku H, Okazawa H.
    • Journal Title

      Curr Mol Med.

      Volume: 15 Pages: 119-28

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Journal Article] Comprehensive phosphoproteome analysis unravels the core signaling network that initiates the earliest synapse pathology in preclinical Alzheimer's disease brain.2015
    • Author(s)
      Tagawa, K., H. Homma, A. Saito, K. Fujita, X. Chen, S. Imoto, T. Oka, H. Ito, K. Motoki, C. Yoshida, H. Hatsuta, Murayama, S., T. Iwatsubo, S. Miyano and H. Okazawa
    • Journal Title

      Hum Mol Genet

      Volume: 印刷中

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-221S0003

  • [Journal Article] Fasting activates macroautophagy in neurons of Alzheimer's disease mouse model but is insufficient to degrade amyloid-beta.2015
    • Author(s)
      Chen, X., Kondo, K., Motoki, K., Homma, H., Okazawa H.
    • Journal Title

      Scientific Reports.

      Volume: 5

    • DOI

      10.1038/srep12115

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26640037

  • [Journal Article] Impaired DNA damage repair as a common feature of neurodegenerative diseases and psychiatric disorders.2015
    • Author(s)
      Shiwaku H, Okazawa H.
    • Journal Title

      Curr Mol Med.

      Volume: 15 Pages: 119-28

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Journal Article] HMGB1 facilitates repair of mitochondrial DNA damage and extends the lifespan of mutant ataxin-1 knock-in mice2015
    • Author(s)
      Ito H, Fujita K, Tagawa K, Chen X, Homma H, Sasabe T, Shimizu J, Shimizu S, Tamura T, Muramatsu S, Okazawa H.
    • Journal Title

      EMBO molecular medicine

      Volume: 7 Pages: 78-101

    • DOI

      10.15252/emmm.201404392

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-ORGANIZER-22110001, KAKENHI-PROJECT-24500378, KAKENHI-PROJECT-26350982, KAKENHI-PROJECT-26640037

  • [Journal Article] Comprehensive phosphoproteome analysis unravels the core signaling network that initiates the earliest synapse pathology in preclinical Alzheimer's disease brain.2015
    • Author(s)
      Tagawa K, Homma H, Saito A, Fujita K, Chen X, Imoto S, Oka T, Ito H, Motoki K, Yoshida C, Hatsuta H, Murayama S, Iwatsubo T, Miyano S, Okazawa H.
    • Journal Title

      Hum Mol Genet

      Volume: 24 Pages: 540-558

    • DOI

      10.1093/hmg/ddu475

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-ORGANIZER-22110001, KAKENHI-PLANNED-22110002, KAKENHI-PROJECT-24500378, KAKENHI-PROJECT-26640037

  • [Journal Article] In utero gene therapy rescues microcephaly caused by Pqbp1-hypofunction in neural stem progenitor cells2015
    • Author(s)
      Ito H, Shiwaku H, Yoshida C, Homma H, Luo H, Chen X, Fujita K, Musante L, Fischer U, Frints SG, Romano C, Ikeuchi Y, Shimamura T, Imoto S, Miyano S, Muramatsu SI, Kawauchi T, Hoshino M, Sudol M, Arumughan A, Wanker EE, Rich T, Schwartz C, Matsuzaki F, Bonni A, Kalscheuer VM, Okazawa H.
    • Journal Title

      Mol. Psychiatry

      Volume: 20 Pages: 78-101

    • DOI

      10.1038/mp.2014.69

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-ORGANIZER-22110001, KAKENHI-PLANNED-22110002, KAKENHI-PLANNED-24113006, KAKENHI-PROJECT-24300138, KAKENHI-PUBLICLY-25110729, KAKENHI-PUBLICLY-25110742, KAKENHI-PUBLICLY-25115733, KAKENHI-PROJECT-25460501, KAKENHI-PUBLICLY-26118505, KAKENHI-PROJECT-26640037, KAKENHI-PUBLICLY-26110718, KAKENHI-PROJECT-26290015, KAKENHI-PROJECT-26293213

  • [Journal Article] Impaired DNA damage repair as a common feature of neurodegenerative diseases and psychiatric disorders.2015
    • Author(s)
      Shiwaku H, Okazawa H.
    • Journal Title

      Curr Mol Med.

      Volume: 15 Pages: 119-28

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26640037

  • [Journal Article] Segmental isotope-labeling of the intrinsically disordered protein PQBP1.2014
    • Author(s)
      Nabeshima Y, Mizuguchi M, Kajiyama A, Okazawa H.
    • Journal Title

      FEBS Letters

      Volume: 588 Pages: 4583-4589

    • DOI

      10.1016/j.febslet.2014.10.028

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-ORGANIZER-22110001, KAKENHI-PLANNED-22110002, KAKENHI-PROJECT-24590049, KAKENHI-PROJECT-26640037

  • [Journal Article] Systems biology alalysis of Drosophila in vivo screen data elucidates core networks for DNA damage repair in SCA12014
    • Author(s)
      Barclay, S.S., Tamura, T., Ito H., Fujita, K., Tagawa, K., Shimamura, T., Katsuta, A., Shiwaku, H., Sone, M., Imoto, S., Miyano, S. and Okazawa, H.
    • Journal Title

      Hum Mol Genet.

      Volume: 23 Pages: 1345-1364

    • DOI

      10.1093/hmg/ddt524

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-ORGANIZER-22110001, KAKENHI-PLANNED-22110002, KAKENHI-PROJECT-23500401, KAKENHI-PROJECT-24500378, KAKENHI-PROJECT-24700374, KAKENHI-PROJECT-25730173

  • [Journal Article] HMGB1 facilitates repair of mitochondrial DNA damage and extends the lifespan of mutant ataxin-1 knock-in mice.2014
    • Author(s)
      Ito H, Fujita K, Tagawa K, Chen X, Homma H, Sasabe T, Shimizu J, Shimizu S, Tamura T, Muramatsu S, Okazawa H.
    • Journal Title

      EMBO Mol Med.

      Volume: 7 Pages: 78-101

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Journal Article] 神経変性疾患の細胞死とHippo pathway －神経変性はHippo pathwayで制御されるか？2014
    • Author(s)
      田村拓也、岡澤均
    • Journal Title

      医学のあゆみ

      Volume: 251 Pages: 449-454

    • Data Source
      KAKENHI-PROJECT-26350982

  • [Journal Article] Systematic Analysis of Fly Models with Multiple Drivers Reveals Different Effects of Ataxin-1 and Huntingtin in Neuron Subtype-Specific Expression.2014
    • Author(s)
      Risa Shiraishi, Takuya Tamura, Masaki Sone, Hitoshi Okazawa
    • Journal Title

      PLoS One.

      Volume: 9

    • DOI

      10.1371/journal.pone.0116567

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26350982, KAKENHI-PROJECT-26430065, KAKENHI-PROJECT-26640037

  • [Journal Article] Mutations in the PQBP1 gene prevent its interaction with the spliceosomal protein U5-15kD.2014
    • Author(s)
      Mizuguchi, M., Obita, T., Serita, T., Kojima, R.,Nabeshima, Y., Okazawa. H
    • Journal Title

      Nature Commun

      Volume: 5 Pages: 3822-3822

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Journal Article] Mutations in the PQBP1 gene prevent its interaction with the spliceosomal protein U5-15kD2014
    • Author(s)
      Mizuguchi, M., Obita, T., Serita, T., Kojima, R., Nabeshima, Y., and Okazawa, H.
    • Journal Title

      Nat Commun

      Volume: 5 Pages: 3822-3822

    • DOI

      10.1038/ncomms4822

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-14J00404, KAKENHI-PLANNED-21113003, KAKENHI-PLANNED-22110002, KAKENHI-PROJECT-24590049, KAKENHI-PROJECT-26640037, KAKENHI-PROJECT-26840018

  • [Journal Article] Omicsからみた神経変性疾患の病態機序.2013
    • Author(s)
      藤田　慶大、岡澤　均
    • Journal Title

      医学のあゆみ

      Volume: 247 Pages: 401-406

    • Data Source
      KAKENHI-PLANNED-22110002

  • [Journal Article] A restricted level of PQBP1 is needed for the best longevity of Drosophila2013
    • Author(s)
      Takuya Tamura , Masaki Sone , Yoko Nakamura, Teppei Shimamura, Seiya Imoto, Satoru Miyano, Hitoshi Okazawa
    • Journal Title

      Neurobiology of Aging

      Volume: 34巻

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23500401

  • [Journal Article] A functional deficiency of TERA/VCP/p97 contributes to impaired DNA damage repair in multiple polyglutamine diseases.2013
    • Author(s)
      Fujita K, Nakamura Y, Oka T, Ito H, Tamura T, Tagawa K, Sasabe T, Katsuta A, Motoki K, Shiwaku H, Sone M, Yoshida C, Katsuno M, Eishi Y, Murata M, Taylor JP, Wanker EE, Kono K, Tashiro S, Sobue G, La Spada AR, Okazawa H.
    • Journal Title

      Nature Commun

      Volume: 4 Pages: 1816-1816

    • DOI

      10.1038/ncomms2828

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229011, KAKENHI-ORGANIZER-22110001, KAKENHI-PLANNED-22110002, KAKENHI-PLANNED-22110005, KAKENHI-PROJECT-23390230, KAKENHI-PROJECT-23500401, KAKENHI-PROJECT-24500378, KAKENHI-PROJECT-24700374, KAKENHI-PROJECT-25640066

  • [Journal Article] Sox2 transcriptionally regulates PQBP1, an Intellectual Disabililty-Microcephary causative gene, in neural stem progenitor cells2013
    • Author(s)
      Li, C., Ito, H., Fujita, K., Shiwaku, H., Yunlong Qi, Y., Tagawa, K., Tamura, T., Okazawa, H.
    • Journal Title

      PLOS ONE

      Volume: 8

    • DOI

      10.1371/journal.pone.0068627

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-22110001, KAKENHI-PLANNED-22110002, KAKENHI-PROJECT-23500401, KAKENHI-PROJECT-24700374

  • [Journal Article] HD Research Around the World: Japan. Past, Present, Future.2013
    • Author(s)
      Okazawa H.
    • Journal Title

      HD Insights

      Volume: 4 Pages: 7-8

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Journal Article] Omicsからみた神経変性疾患の病態機序.2013
    • Author(s)
      藤田　慶大、岡澤　均
    • Journal Title

      医学のあゆみ

      Volume: 247 Pages: 401-406

    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Journal Article] HD Research Around the World: Japan. Past, Present, Future.2013
    • Author(s)
      Okazawa,H.
    • Journal Title

      HD insights

      Volume: 4 Pages: 7-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Journal Article] Polyglutamine tract-binding protein 1の構造生物学的研究.2013
    • Author(s)
      水口　峰之、岡澤　均
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 133 Pages: 519-526

    • NAID

      130003361945

    • Data Source
      KAKENHI-PLANNED-22110002

  • [Journal Article] Polyglutamine tract-binding protein 1の構造生物学的研究.2013
    • Author(s)
      水口　峰之、岡澤　均
    • Journal Title

      YAKUGAKU　ZASSHI

      Volume: 133 Pages: 519-526

    • NAID

      130003361945

    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Journal Article] The XLID protein PQBP1 and the GTPase dynamin 2 define a signaling link that orchestrates ciliary morphogenesis in postmitotic neurons.2013
    • Author(s)
      Ikeuchi, Y., de la Torre, L., Matsuda, T., Steen, H., Okazawa, H., Bonni, A.
    • Journal Title

      Cell Reports

      Volume: 4 Pages: 1-11

    • DOI

      10.1016/j.celrep.2013.07.042

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-22110001, KAKENHI-PLANNED-22110002

  • [Journal Article] Bergmann glia are reduced in spinocerebellar ataxia type 1.2013
    • Author(s)
      Shiwaku H, Yagishita S, Eishi Y, Okazawa H.
    • Journal Title

      Neuroreport

      Volume: 24 Pages: 620-625

    • DOI

      10.1097/wnr.0b013e32836347b7

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-22110001, KAKENHI-PLANNED-22110002

  • [Journal Article] A restricted level of PQBP1 is needed for the best longevity of Drosophila.2013
    • Author(s)
      Takuya Tamura, Masaki Sone, Yoko Nakamura, Teppei Shimamura, Seiya Imoto, Satoru Miyano, Hitoshi Okazawa
    • Journal Title

      Neurobiology of Aging.

      Volume: 34 Pages: 11-20

    • DOI

      10.1016/j.neurobiolaging.2012.07.015

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23500401, KAKENHI-ORGANIZER-22110001

  • [Journal Article] Increased glucose metabolism by FDG-PET correlates with reduced tumor angiogenesis in oral squamous cell carcinoma2012
    • Author(s)
      Nakamura, Y., Tagawa, K., Oka, T., Sasabe, T., Ito, H., Shiwaku, H., La Spada, A. R. and Okazawa, H
    • Journal Title

      Hum Mol Genet.

      Volume: 21(5) Pages: 1099-1110

    • DOI

      10.1093/hmg/ddr539

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390265, KAKENHI-PROJECT-21390342, KAKENHI-PLANNED-22110002, KAKENHI-PROJECT-23700373, KAKENHI-PROJECT-24500378, KAKENHI-ORGANIZER-22110001

  • [Journal Article] 脳疾患のバイオマーカーとオプトジェネティクス2012
    • Author(s)
      岡澤均
    • Journal Title

      実験医学

      Volume: 30 Pages: 2548-2593

    • Data Source
      KAKENHI-PLANNED-22110002

  • [Journal Article] 脳疾患のバイオマーカーとオプトジェネティクス2012
    • Author(s)
      岡澤均
    • Journal Title

      実験医学

      Volume: 30 Pages: 2548-2593

    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Journal Article] 概論：技術革新による神経科学の新潮流2012
    • Author(s)
      岡澤均
    • Journal Title

      実験医学

      Volume: 30 Pages: 2548-2553

    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Journal Article] The solution model of the intrinsically disordered polyglutamine tract binding protein-1 (PQBP-1)2012
    • Author(s)
      Ress, M., Gorba, C., Gorba, C., de Chiara, C., Bui, T.T.T., Garcia-Maya, M., Drake, A.F., Okazawa, H., Pastre, A., Svergun, D., Chen, Y.W.
    • Journal Title

      Biophys J

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Journal Article] 概論：技術革新による神経科学の新潮流2012
    • Author(s)
      岡澤均
    • Journal Title

      実験医学

      Volume: 30 Pages: 2548-2553

    • Data Source
      KAKENHI-PLANNED-22110002

  • [Journal Article] The solution model of the intrinsically disordered polyglutamine tract binding protein-1(PQBP-1)2012
    • Author(s)
      Ress, M., Gorba, C., Gorba, C., de Chiara, C., Bui, T. T. T., Garcia-Maya, M., Drake, A. F., Okazawa, H., Pastre, A., Svergun, D. and Chen, Y. W
    • Journal Title

      Biophys J

      Volume: (in press)

    • Data Source
      KAKENHI-PROJECT-21390265

  • [Journal Article] Ku70 alleviates neurodegeneration in Drosophila models of Huntington's disease2011
    • Author(s)
      Tamura, T., Sone, M., Iwatsubo, T., Tagawa, K., Wanker, E. E. and Okazawa, H
    • Journal Title

      PLoS One

      Volume: 6

    • DOI

      10.1371/journal.pone.0027408

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390265, KAKENHI-ORGANIZER-22110001, KAKENHI-PLANNED-22110002, KAKENHI-PROJECT-23500401

  • [Journal Article] Dynamic Changes of the Phosphoproteome in Postmortem Mouse Brains2011
    • Author(s)
      Oka, T., Tagawa, K., Ito, H. and Okazawa, H
    • Journal Title

      PLoS One

      Volume: 6

    • DOI

      10.1371/journal.pone.0021405

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390265, KAKENHI-ORGANIZER-22110001, KAKENHI-PLANNED-22110002

  • [Journal Article] Mutant Huntingtin impairs Ku70-mediated DNA repair2010
    • Author(s)
      Enokido Y, Tamura T, Ito H, Arumughan A, Komuro A, Shiwaku H, Sone M, Foulle R, Sawada H, Ishiguro H, Ono T, Murata M, Kanazawa I, Tomilin N, Tagawa K, Wanker EE, Okazawa H.
    • Journal Title

      Journal of Cell Biology

    • Data Source
      KAKENHI-PROJECT-20058010

  • [Journal Article] Drosophila PQBP1 regulates learning acquisition at projection neurons in aversive olfactory conditioning2010
    • Author(s)
      Tamura, T., Horiuchi, D., Chen, Y. C., Sone, M., Miyashita, T., Saitoe, M., Yoshimura, N., Chiang, A. S., and Okazawa, H.
    • Journal Title

      J Neurosci

      Volume: 30 Pages: 14091-14101

    • Data Source
      KAKENHI-PROJECT-21390265

  • [Journal Article] Suppression of thenovel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity2010
    • Author(s)
      Shiwaku, H., Yoshimura, N., Tamura, T., Sone, M., Ogishima, S., Watase, K., Tagawa, K., and Okazawa, H.
    • Journal Title

      EMBO Journal

      Volume: 29 Pages: 2446-2460

    • DOI

      10.1038/emboj.2010.116

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390265, KAKENHI-PROJECT-22700311

  • [Journal Article] In-frame Dystrophin Following Exon 51-Skipping Improves Muscle Pathology and Function in the Exon 52-Deficient mdx Mouse.2010
    • Author(s)
      Aoki, Y., Nakamura, A., Yokota, T., Saito, T., Okazawa, H., Nagata, T., Takeda, S.
    • Journal Title

      Molecular Therapy

      Volume: 18 Pages: 1995-2005

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Journal Article] Mutant Huntingtin impairs Ku70-mediated DNA repair.2010
    • Author(s)
      Enokido Y, Tamura T, Ito H, Arumughan A, Komuro A, Shiwaku H, Sone M, Foulle R, Sawada H, Ishiguro H, Ono T, Murata M, Kanazawa I, Tomilin N, Tagawa K, Wanker EE, Okazawa H.
    • Journal Title

      Journal of Cell Biology 189

      Pages: 425-443

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Journal Article] Drosophila PQBPl regulates learning acquisition at prqlection neurons in aversive olfactory conditioning.2010
    • Author(s)
      Tamura, T., Horiuchi, D., Chen, YC., Sone, M., Miyashita, T., Saitoe, M, Yoshimura, N., Chiang, A.S., Okazawa, H.
    • Journal Title

      The Journal of Neuroscience

      Volume: 30 Pages: 14091-14101

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Journal Article] Copy-number variations on the X chromosome in Japanese patients with mental retardation detected by array-based comparative genomic hybridization analysis.2010
    • Author(s)
      Honda, S., Hayashi, S., Imoto, I., Toyama, J., Okazawa, H., Nakagawa, E., Goto, Y., Inazawa, J.
    • Journal Title

      Journal of Human Genetics

      Volume: 55 Pages: 590-599

    • NAID

      10030736689

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Journal Article] Polyglutamine tract-binding protein-1 binds to U5-15kD via a continuous 23-residue segment of the C-terminal domain.2010
    • Author(s)
      Takahashi, M., Mizuguchi, M., Shinoda, H., Aizawa, T., Demura, M., Okazawa, H., Kawano, K.
    • Journal Title

      Biochimica et Biophysica Acta

      Volume: 1804 Pages: 1500-1507

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Journal Article] Mutant huntingtin impairs Ku70-mediated DNA repair2010
    • Author(s)
      Enokido, Y., Tamura, T., Ito, H., Arumughan, A., Komuro, A., Shiwaku, H., Sone, M., Foulle, R., Sawada, H., Ishiguro, H., Ono, T., Murata, M., Kanazawa, I., Tomilin, N., Tagawa, K., Wanker, E. E., and Okazawa, H.
    • Journal Title

      J CellBiol

      Volume: 189 Pages: 425-443

    • DOI

      10.1083/jcb.200905138

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Journal Article] Copy-number variations on the X chromosome in Japanese patients withmental retardation detected by array-based comparative genomic hybridization analysis.2010
    • Author(s)
      Honda, S., Hayashi, S., Imoto, I., Tbyama, J., Okazawa, H., Nakagawa, E., Goto, Y, Inazawa, J.
    • Journal Title

      Journal of Human Genetics

      Volume: 55 Pages: 590-599

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Journal Article] Efficiently differentiating vascular endothelial cells from adipose tissue-derived mesenchymal stem cells in serum-freeculture2010
    • Author(s)
      Konno, M., Hamazaki, T. S., Fukuda, S., Tokuhara, M., Uchiyama, H., Okazawa, H., Okochi, H., and Asashima, M.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 400 Pages: 461-465

    • DOI

      10.1016/j.bbrc.2010.08.029

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Journal Article] Suppression of the novel ER protein Maxer by mutant ataxin- 1 in Bergmanglia contributes to non-cell-autonomous toxicity.2010
    • Author(s)
      Shiwaku, H., Yoshimura, N., Tamura, T., Sone, M., Ogishima, S., Watase, K., Tagawa, K., Okazawa, H.
    • Journal Title

      The EMBO Journal

      Volume: 29 Pages: 2446-2460

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Journal Article] Polyglutamine tract-binding protein-1 binds to U5-15kD via a continuous 23-residue segment of the C-terminal domain.2010
    • Author(s)
      Takahashi, M., Mizuguchi, M., Shinoda, H., Aizawa, T., Demura, M., Okazawa, H., Kawano, K.
    • Journal Title

      Biochimica et Biophysica Acta

      Volume: 1804 Pages: 1500-1507

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Journal Article] Efficiently differentiating vascular endothelial cells from adipose tissue-derived mesenchymal stem cells in serum-free culture.2010
    • Author(s)
      Konno, M., Hamazaki, T.S., Fukuda, S., Tokuhara, M., Uchiyama, H., Okazawa, H., Okochi, H., Asashima, M.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 400 Pages: 461-465

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Journal Article] Copy-number variations on the X chromosome in Japanese patients with mental retardation detected by array-based comparative genomic hybridization analysis.2010
    • Author(s)
      Honda, S., Hayashi, S., Imoto, I., Toyama, J., Okazawa, H., Nakagawa, E., Goto, Y., Inazawa, J.
    • Journal Title

      Journal of Human Genetics

      Volume: 55 Pages: 590-599

    • NAID

      10030736689

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Journal Article] Mutant Huntingtin impairs Ku70-mediated DNA repair2010
    • Author(s)
      Enokido Y, Tamura T, Ito H, Arumughan A, Komuro A, Shiwaku H, Sone M, Foulle R, Sawada H, Ishiguro H, Ono T, Murata M, Kanazawa I, Tomilin N, Tagawa K, Wanker EE, Okazawa H.
    • Journal Title

      Journal of Cell Biology

    • Data Source
      KAKENHI-PROJECT-20023011

  • [Journal Article] Copy-number variations on the X chromosome in Japanese patients with mental retardation detected by array-based comparative genomic hybridization analysis2010
    • Author(s)
      Honda, S., Hayashi, S., Imoto, I., Toyama, J., Okazawa, H., Nakagawa, E., Goto, Y., and Inazawa, J.
    • Journal Title

      J Hum Genet

      Volume: 55 Pages: 590-599

    • DOI

      10.1038/jhg.2010.74

    • NAID

      10030736689

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Journal Article] 天然変性タンパク質PQBP-1の揺らぎと生体機能2010
    • Author(s)
      水口峰之、岡澤均
    • Journal Title

      メディカルバイオ「揺らぎと生体機能」

      Volume: 10月別冊 Pages: 44-48

    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Journal Article] Suppression of the novel ER protein Maxer by mutant ataxin- 1 in Bergmanglia contributes to non-cell-autonomous toxicity.2010
    • Author(s)
      Shiwaku, H., Yoshimura, N., Tamura, T., Sone, M., Ogishima, S., Watase, K., Tagawa, K., Okazawa, H.
    • Journal Title

      The EMBO Journal

      Volume: 29 Pages: 2446-2460

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Journal Article] In-frame Dystrophin Following Exon 51-Skipping Improves Muscle Pathology and Function in the Exon 52-Deficient mdx Mouse.2010
    • Author(s)
      Aoki, Y, Nakamura, A., Yokota, T, Saito, T, Okazawa.H., Nagata, T, Takeda, S.
    • Journal Title

      Molecular Therapy

      Volume: 18 Pages: 1995-2005

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Journal Article] Mutant huntingtin impairs Ku70-mediated DNA repair2010
    • Author(s)
      Enokido, Y, Tamura, T., ItO, H, Arumughan, A., Komuro, A., Shiwaku, H., Sone, M., Foulle, R., Sawada, H., Ishiguro, H., Ono, T., Murata, M., Kanazawa, I., Tomilin, N., Tagawa, K, Wanker, E.E., Okazawa.H.
    • Journal Title

      The Journal of Cell Biology

      Volume: 189 Pages: 425-443

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Journal Article] Polyglutamine tract-binding protein-1 binds to U5-15kD via a continuous 23-residue segment of the C-terminal domain2010
    • Author(s)
      Takahashi, M., Mizuguchi, M., Shinoda, H., Aizawa, T., Demura, M., Okazawa, H., and Kawano, K.
    • Journal Title

      Biochim Biophys Acta

      Volume: 1804 Pages: 1500-1507

    • DOI

      10.1016/j.bbapap.2010.03.007

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Journal Article] In-frame Dystrophin Following Exon 51-Skipping Improves Muscle Pathology and Function in the Exon 52-Deficient mdx Mouse2010
    • Author(s)
      Aoki, Y., Nakamura, A., Yokota, T., Saito, T., Okazawa, H., Nagata, T., and Takeda, S
    • Journal Title

      Mol Ther

      Volume: 18 Pages: 1995-200

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Journal Article] PQBP1異常による発達障害の分子機構2010
    • Author(s)
      伊藤日加瑠、岡澤均
    • Journal Title

      実験医学 28

      Pages: 706-12

    • Data Source
      KAKENHI-PROJECT-21390265

  • [Journal Article] In-frame Dystrophin Following Exon 51-Skipping Improves Muscle Pathology and Function in the Exon 52-Deficient mdx Mouse.2010
    • Author(s)
      Aoki, Y., Nakamura, A., Yokota, T., Saito, T., Okazawa, H., Nagata, T., Takeda, S.
    • Journal Title

      Molecular Therapy

      Volume: 18 Pages: 1995-2005

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Journal Article] 天然変性タンパク質PQBP-1の揺らぎと生体機能2010
    • Author(s)
      水口峰之、岡澤均
    • Journal Title

      メディカルバイオ「揺らぎと生体機能」

      Volume: 10月別冊 Pages: 44-48

    • Data Source
      KAKENHI-PROJECT-21390265

  • [Journal Article] PQBP1異常による発達障害の分子機構2010
    • Author(s)
      伊藤日加瑠、岡澤均
    • Journal Title

      実験医学 28

      Pages: 706-12

    • Data Source
      KAKENHI-PROJECT-20058010

  • [Journal Article] 天然変性タンパク質PQBP-1の揺らぎと生体機能2010
    • Author(s)
      水口峰之、岡澤均
    • Journal Title

      メディカルバイオ「揺らぎと生体機能」

      Volume: 10月別冊 Pages: 44-48

    • Data Source
      KAKENHI-PLANNED-22110002

  • [Journal Article] Drosophila PQBP1 regulates learning acquisition at projection neurons in aversive olfactory conditioning.2010
    • Author(s)
      Tamura, T., Horiuchi, D., Chen, Y.C., Sone, M., Miyashita, T., Saitoe, M., Yoshimura, N., Chiang, A.S., Okazawa, H.
    • Journal Title

      The Journal of Neuroscience

      Volume: 30 Pages: 14091-14101

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Journal Article] PQBP1異常による発達障害の分子機構2010
    • Author(s)
      伊藤日加瑠、岡澤均
    • Journal Title

      実験医学 128

      Pages: 706-12

    • Data Source
      KAKENHI-PROJECT-20023011

  • [Journal Article] Effciently differentiating vascular endothelial cells from adipose tissue-derived mesenchymal stem cells in serum-free culture.2010
    • Author(s)
      Konno, M., Hamazaki, T.S., Fukuda, S., Tobkuhara, M., Uchiyama, H., Okazawa, H., Okochi, H., Asashima, M.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 400 Pages: 461-465

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Journal Article] Polyglutamine tract-binding protein-1binds to U5-15kD via a continuous 23-residue segment of the C-terminal domain.2010
    • Author(s)
      Takahashi, M., Mizuguchi, M., Shinoda, E, Aizawa, T., Demura, M., Okazawa, H., Kawano, K.
    • Journal Title

      Biochimica et Biophysica Acta

      Volume: 1804 Pages: 1500-1507

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Journal Article] Drosophila PQBP1 regulates learning acquisition at projection neurons in aversive olfactory conditioning.2010
    • Author(s)
      Tamura, T., Horiuchi, D., Chen, Y.C., Sone, M., Miyashita, T., Saitoe, M., Yoshimura, N., Chiang, A.S., Okazawa, H.
    • Journal Title

      The Journal of Neuroscience

      Volume: 30 Pages: 14091-14101

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Journal Article] Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cel-autonomous toxicity2010
    • Author(s)
      Shiwaku, H., Yoshimura, N., Tamura, T., Sone, M., Ogishima, S., Watase, K., Tagawa, K., Okazawa.H.
    • Journal Title

      The EMBO Journal

      Volume: 29 Pages: 2446-2460

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Journal Article] Efficiently differentiating vascular endothelial cells from adipose tissue-derived mesenchymal stem cells in serum-free culture.2010
    • Author(s)
      Konno, M., Hamazaki, T.S., Fukuda, S., Tokuhara, M., Uchiyama, H., Okazawa, H., Okochi, H., Asashima, M.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 400 Pages: 461-465

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Journal Article] Knock-down of PQBP1 impairs anxiety-related cognition in mouse2009
    • Author(s)
      Ito, H., Yoshimura, N., Kurosawa, M., Ishii, S., Nukina, N., and Okazawa, H.
    • Journal Title

      Hum Mol Genet

      Volume: 18 Pages: 4239-4254

    • DOI

      10.1093/hmg/ddp378

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Journal Article] Knock down of PQBP1 impairs anxiety-related cognition in mouse2009
    • Author(s)
      Ito H, Yoshimura N, Kurosawa M, Ishii S, Nukina N, Okazawa H.
    • Journal Title

      Human Molecular Genetics 18

      Pages: 4539-54

    • Data Source
      KAKENHI-PROJECT-20058010

  • [Journal Article] Loss of yata, a novel gene regulating the subcellular localization of APPL, induces deterioration of neural tissues and lifespan shortening2009
    • Author(s)
      Sone M, Uchida A, Komatsu A, Suzuki E, Ibuki I, Asada M, Shiwaku H, Tamura T, Hoshino M, OkazawaH, Nabeshima Y
    • Journal Title

      PLoS One

      Volume: 4

    • DOI

      10.1371/journal.pone.0004466

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19670002, KAKENHI-PROJECT-21390265

  • [Journal Article] Pol II特異的阻害薬、α-アマニチンが引き起こす非特異的で緩慢な細胞死(TRIAD)2009
    • Author(s)
      田村拓也、岡澤均
    • Journal Title

      ケミカルバイオロジー 2

      Pages: 13-13

    • Data Source
      KAKENHI-PROJECT-20058010

  • [Journal Article] Polyglutamine tract binding protein-1 is an intrinsically unstructured protein.2009
    • Author(s)
      Takahashi M, Mizuguchi M, Shinoda H, Aizawa T, Demura M, Okazawa H, Kawano K
    • Journal Title

      Biochimica et Biophysica Acta 1794

      Pages: 936-43

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Journal Article] Pol II特異的阻害薬、α-アマニチンが引き起こす非特異的で緩慢な細胞死(TRIAD)2009
    • Author(s)
      田村拓也、岡澤均
    • Journal Title

      ケミカルバイオロジー 2

      Pages: 13-13

    • Data Source
      KAKENHI-PROJECT-20023011

  • [Journal Article] Knock down of PQBP1 impairs anxiety-related cognition in mouse.2009
    • Author(s)
      Ito H, Yoshimura N, Kurosawa M, Ishii S, Nukina N, Okazawa H.
    • Journal Title

      Human Molecular Genetics 18

      Pages: 4539-54

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Journal Article] Polyglutamine tract binding protein-1 is an intrinsically unstructured protein2009
    • Author(s)
      Takahashi M, Mizuguchi M, Shinoda H, Aizawa T, Demura M, Okazawa H, Kawano K
    • Journal Title

      Biochimica et Biophysica Acta 1794

      Pages: 936-43

    • Data Source
      KAKENHI-PROJECT-20023011

  • [Journal Article] Polyglutamine tract binding protein-1 is an intrinsically unstructured protein2009
    • Author(s)
      Takahashi, M., Mizuguchi, M., Shinoda, H., Aizawa, T., Demura, M., Okazawa, H., and Kawano, K.
    • Journal Title

      Biochim Biophys Acta

      Volume: 1794 Pages: 936-943

    • DOI

      10.1016/j.bbapap.2009.03.001

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Journal Article] Neural stem cells express Oct-3/42009
    • Author(s)
      Chin JH, Shiwaku H, Goda O, Komuro A, Okazawa H.
    • Journal Title

      Biochemical and Biophysical Research Communications 388

      Pages: 247-51

    • Data Source
      KAKENHI-PROJECT-20023011

  • [Journal Article] Pol II特異的阻害薬、α-アマニチンが引き起こす非特異的で緩慢な細胞死(TRIAD)2009
    • Author(s)
      田村拓也、岡澤均
    • Journal Title

      ケミカルバイオロジー 12

      Pages: 13-13

    • Data Source
      KAKENHI-PROJECT-21390265

  • [Journal Article] Knock down of PQBP1 impairs anxiety-related cognition in mouse2009
    • Author(s)
      Ito H, Yoshimura N, Kurosawa M, Ishii S, Nukina N, Okazawa H.
    • Journal Title

      Human Molecular Genetics 18

      Pages: 4539-54

    • Data Source
      KAKENHI-PROJECT-20023011

  • [Journal Article] Nematode homologue of PQBP1, a mental retardation causative gene, is involved in lipid metabolism2009
    • Author(s)
      Takahashi, K., Yoshina, S., et al(9名中5番目)
    • Journal Title

      PLoS One

      Volume: 4

    • DOI

      10.1371/journal.pone.0004104

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21200075, KAKENHI-PROJECT-21390265

  • [Journal Article] Polyglutamine tract binding protein-1 is an intrinsically unstructured protein2009
    • Author(s)
      Takahashi M, Mizuguchi M, Shinoda H, Aizawa T, Demura M, Okazawa H, Kawano K
    • Journal Title

      Biochimica et Biophysica Acta 1794

      Pages: 936-43

    • Data Source
      KAKENHI-PROJECT-20058010

  • [Journal Article] Glial cell lineage expression of mutant ataxin-1 and huntingtin induces developmental and late-onset neuronal pathologies in Drosophila models2009
    • Author(s)
      Tamura, T., Sone, M., Yamashita, M., Wanker, E. E., and Okazawa, H.
    • Journal Title

      PLoS One

      Volume: 4

    • DOI

      10.1371/journal.pone.0004262

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Journal Article] Progressive decrease in the level of YAPdeltaCs, prosurvival isoforms of YAP, in the spinal cord of transgenic mouse carrying a mutant SOD1 gene2009
    • Author(s)
      Morimoto, N., Nagai, M., Miyazaki, K., Kurata, T., Takehisa, Y., Ikeda, Y., Kamiya, T., Okazawa, H., and Abe, K.
    • Journal Title

      J Neurosci Res

      Volume: 87 Pages: 928-936

    • DOI

      10.1002/jnr.21902

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Journal Article] Neural stem cells express Oct-3/4.2009
    • Author(s)
      Chin JH, Shiwaku H, Goda O, Komuro A, Okazawa H.
    • Journal Title

      Biochemical and Biophysical Research Communications. 388

      Pages: 247-51

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Journal Article] Neural stem cells express Oct-3/42009
    • Author(s)
      Chin, J. H., Shiwaku, H., Goda, O., Komuro, A., and Okazawa, H.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 388 Pages: 247-251

    • DOI

      10.1016/j.bbrc.2009.07.165

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Journal Article] Neural stem cells express Oct-3/42009
    • Author(s)
      Chin JH, Shiwaku H, Goda O, Komuro A, Okazawa H.
    • Journal Title

      Biochemical and Biophysical Research Communications 388

      Pages: 247-51

    • Data Source
      KAKENHI-PROJECT-20058010

  • [Journal Article] Age-dependent change of HMGB1 and DNA double-strand break accumulation in mouse brain2008
    • Author(s)
      Enokido, Y., Yoshitake, A., Ito, H., and Okazawa, H.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 376 Pages: 128-133

    • DOI

      10.1016/j.bbrc.2008.08.108

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Journal Article] Omi/HtrA2 is relevant to the selective vulnerability of striatal neurons in Huntington's disease2008
    • Author(s)
      Inagaki, R., Tagawa, K., Qi, M. L., Enokido, Y., Ito, H., Tamura, T., Shimizu, S., Oyanagi, K., Arai, N., Kanazawa, I., Wanker E. E, and Okazawa, H.
    • Journal Title

      Eur J Neurosci

      Volume: 28 Pages: 30-40

    • DOI

      10.1111/j.1460-9568.2008.06323.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Journal Article] Proteome analysis of soluble nuclear proteins reveals that HMGB1/2 suppress genotoxic stress in polyglutamine diseases.2007
    • Author(s)
      Qi M-L, Tagawa K, Enokido Y, Yoshimura N, Wada Y-I, Watase K, Ishimura S-I, Kanazawa I, Botas J, Saitoe M, Wanker E. E, and Okazawa H.
    • Journal Title

      Nature Cell Biology 9

      Pages: 402-414

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18650097

  • [Journal Article] Proteome analysis of soluble nuclear proteins reveals that HMGB1/2 suppress genotoxic stress in polyglutamine diseases2007
    • Author(s)
      Qi ML, Tagawa K, Enokido Y, Yoshimura N, Wada Y-I, Watase K, Ishimura SI, Kanazawa I, Botas J, Saitoe M, Wanker E. E,and Okazawa H.
    • Journal Title

      Nature Cell Biology 9

      Pages: 402-414

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390254

  • [Journal Article] Proteome analysis of soluble nuclear proteins reveals that HMGB1/2 suppress genotoxic stress in polyglutamine diseases.2007
    • Author(s)
      Qi ML, Tagawa K, Enokido Y, Yoshimura N, Wada Yi, Watase K, Ishimura SI, Kanazawa I, Botas J, Saitoe M, Wanker E.E, and Okazawa H.
    • Journal Title

      Nature Cell Biology 9

      Pages: 402-414

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390254

  • [Journal Article] The induction levels of hsp70 differentiate the vulnerbilitiees to mutant huntingtin among neuronal subtypes.2007
    • Author(s)
      Tagawa K, Marubuchi S, Qi M-L, Enokido Y, Tamura T, Inagaki R, Murata M, Kanazawa I, Wanker E.E, and Okazawa H.
    • Journal Title

      Journal of Neuroscience 7

      Pages: 868-880

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18023014

  • [Journal Article] Proteome analysis of soluble nuclear proteins reveals that HMGB1/2 suppress genotoxic stress in polyglutamine diseases.2007
    • Author(s)
      Qi M-L, Tagawa K, Enokido Y, Yoshimura N, Wada Y-I, Watase K, Ishimura S-I, Kanazawa I, Botas J, Saitoe M, Wanker E.E, and Okazawa H.
    • Journal Title

      Nature Cell Biology 9

      Pages: 402-414

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390254

  • [Journal Article] Proteome analysis of soluble nuclear proteins reveals that HMGB1/2 suppress genotoxic stress in polyglutamine diseases.2007
    • Author(s)
      Qi M-L, Tagawa K, Enokido Y, Yoshimura N, Wada Y-I, Watase K, Ishimura S-I, Kanazawa I, Botas J, Saitoe M, Wanker E.E, and Okazawa H.
    • Journal Title

      Nature Cell Biology 9

      Pages: 402-414

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18023014

  • [Journal Article] The induction levels of hsp70 differentiate the vulnerbilitiees to mutanthuntingtin among neuronal subtypes.2007
    • Author(s)
      Tagawa K, Marubuchi S, Qi M-L, Enokido Y, Tamura T, Inagaki R, Murata M, Kanazawa I, Wanker E.E, and Okazawa H.
    • Journal Title

      Journal of Neuroscience 7

      Pages: 868-880

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390254

  • [Journal Article] The induction levels of hsp 70 differentiate the vulnerbilitiees to mutant huntingtin among neuronal subtypes2007
    • Author(s)
      Tagawa K, Marubuchi S, Qi ML, Enokido Y, Tamura T, Inagaki R, Murata M, Kanazawa I, Wanker E. E, and Okazawa H.
    • Journal Title

      Journal of Neuroscience 7

      Pages: 868-880

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390254

  • [Journal Article] The induction levels of heat shock protein 70 differentiate the vulnerabilities to mutant huntingtin among neuronal subtypes2007
    • Author(s)
      Tagawa, K., Marubuchi, S., Qi, M. L., Enokido, Y., Tamura, T., Inagaki, R., Murata, M., Kanazawa, I., Wanker, E. E., and Okazawa, H.
    • Journal Title

      J Neurosci

      Volume: 27 Pages: 868-880

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Journal Article] The induction levels of hsp70 differentiate the vulnerbilitiees to mutanthuntingtin among neuronal subtypes.2007
    • Author(s)
      Tagawa K, Marubuchi S, Qi ML, Enokido Y, Tamura T, Inagaki R, Murata M, Kanazawa I, Wanker E.E, and Okazawa H.
    • Journal Title

      Journal of Neuroscience 7

      Pages: 868-880

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390254

  • [Journal Article] The induction levels of hsp70 differentiate the vulnerbilitiees to mutant huntingtin among neuronal subtypes.2007
    • Author(s)
      Tagawa K, Marubuchi S, Qi M-L, Enokido Y, Tamura T, Inagaki R, Murata M, Kanazawa I, Wanker E. E, and Okazawa H.
    • Journal Title

      Journal of Neuroscience 7

      Pages: 868-880

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18650097

  • [Journal Article] Proteome analysis of soluble nuclear proteins reveals that HMGB1/2 suppress genotoxic stress in polyglutamine diseases2007
    • Author(s)
      Qi, M. L., Tagawa, K., Enokido, Y., Yoshimura, N., Wada, Y., Watase, K., Ishiura, S., Kanazawa, I., Botas, J., Saitoe, M., Wanker, E. E., and Okazawa, H.
    • Journal Title

      Nature Cell Biol

      Volume: 9 Pages: 402-414

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Journal Article] Hepatoma-derived growth factor, a new trophic factor for motor neurons, is up-regulated in the spinal cord of PQBP-1 transgenic mice before onset of degeneration2006
    • Author(s)
      Marubuchi S, Okuda T, Tagawa K, Enokido Y, Horiuchi D, Shimokawa R, Tamura T, Qi ML, Eishi Y, Watabe K, Shibata M, Nakagawa M and Okazawa H.
    • Journal Title

      J Neurochem 99

      Pages: 70-83

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390254

  • [Journal Article] Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p732006
    • Author(s)
      Hoshino M, Qi ML, Yoshimura N, Miyashita T, Tagawa K, Wada Yi, Enokido Y, Marubuchi S, Harjes P, Arai N, Oyanagi K, Blandino G, Sudol M, Rich T, Kanazawa 1, Wanker E. E, Saitoe M, and Okazawa H.
    • Journal Title

      Journal of Cell Biology 172

      Pages: 589-604

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390254

  • [Journal Article] Hepatoma-derived growth factor, a new trophic factor for motor neurons, is up-regulated in the spinal cord of PQBP-1 transgenic mice before onset of degeneration.2006
    • Author(s)
      Marubuchi S, Okuda T, Tagawa K, Enokido Y, Horiuchi D, Shimokawa R, Tamura T, Qi ML, Eishi Y, Watabe K, Shibata M, Nakagawa M and Okazawa H
    • Journal Title

      J Neurochem 99

      Pages: 70-83

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390254

  • [Journal Article] Expression of human PQBP-1 in Drosophila impairs long-term memory and induces abnormal courtship.2006
    • Author(s)
      Yoshimura N, Horiuchi D, Shibata M, Saitoe M, Qi ML, and Okazawa H.
    • Journal Title

      FEBS Letter 580

      Pages: 2335-2340

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390254

  • [Journal Article] Expression of human PQBP-1 in Drosophila impairs long-term memory and induces abnormal courtship2006
    • Author(s)
      Yoshimura N, Horiuchi D, Shibata M, Saitoe M, Qi ML, and Okazawa H.
    • Journal Title

      FEBS Letters 580

      Pages: 2335-2340

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390254

  • [Journal Article] Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73.2006
    • Author(s)
      Hoshino M, Qi ML, Yoshimura N, Miyashita T, Tagawa K, Wada Y.i, Enokido Y, Marubuchi S, Harjes P, Arai N, Oyanagi K, Blandino G, Sudol M, Rich T, Kanazawa I, Wanker E.E, Saitoe M, and Okazawa H.
    • Journal Title

      Journal of Cell Biology 172

      Pages: 589-604

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390254

  • [Journal Article] The solution model of the intrinsically disordered polyglutamine tract binding protein-1 (PQBP-1)
    • Author(s)
      Ress, M., Gorba, C., Gorba, C., de Chiara, C., Bui, T.T.T., Garcia-Maya, M., Drake, A.F., Okazawa, H., Pastre, A., Svergun, D., Chen, Y.W.
    • Journal Title

      Biopbys J

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Journal Article] The solution model of the intrinsically disordered polyglutamine tract binding protein-1(PQBP-1)
    • Author(s)
      Ress, M., Gorba, C., Gorba, C., de Chiara, C., Bui, T.T.T., Garcia-Maya, M., Drake A.F., Okazawa, H., Pastre, A., Svergun, D., Chen, Y.W.
    • Journal Title

      Biophys J

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Patent] 軽度認知障害の診断マーカー2020
    • Inventor(s)
      岡澤 均
    • Industrial Property Rights Holder
      岡澤 均
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Overseas
    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Patent] 前頭側頭葉変性症の予防又は治療剤2020
    • Inventor(s)
      岡澤 均
    • Industrial Property Rights Holder
      岡澤 均
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2020-204343
    • Filing Date
      2020
    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Patent] 軽度認知障害の予防又は治療剤2020
    • Inventor(s)
      岡澤 均
    • Industrial Property Rights Holder
      岡澤 均
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Overseas
    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Patent] 軽度認知障害の予防又は治療剤2019
    • Inventor(s)
      岡澤　均
    • Industrial Property Rights Holder
      岡澤　均
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-145259
    • Filing Date
      2019
    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Patent] ｐＳｅｒ４６－ＭＡＲＣＫＳを認識するモノクローナル抗体の配列2019
    • Inventor(s)
      岡澤　均
    • Industrial Property Rights Holder
      岡澤　均
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Overseas
    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Patent] ヒトＨＭＧＢ１に特異的に結合するヒトモノクローナル抗体、及びそれを含有するアルツハイマー病を治療又は予防するための医薬組成物2019
    • Inventor(s)
      岡澤　均
    • Industrial Property Rights Holder
      岡澤　均
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Overseas
    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Patent] アルツハイマー病及び前頭側頭葉変性症の診断方法、診断薬、治療薬、及びこれら薬剤のスクリーニング方法2019
    • Inventor(s)
      岡澤　均
    • Industrial Property Rights Holder
      岡澤　均
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-160228
    • Filing Date
      2019
    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Patent] 軽度認知障害の診断マーカー2019
    • Inventor(s)
      岡澤　均
    • Industrial Property Rights Holder
      岡澤　均
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-112658
    • Filing Date
      2019
    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Patent] ＭＡＲＣＫＳのリン酸化を指標にしたＡＤ（アルツハイマー病）、ＦＴＬＤ（前頭側頭葉変性症）、ＡＬＳ（筋萎縮性側索硬化症）、ＰＤ（パーキンソン病）およびＤＬＢ（レビー小体型認知症）の検出2019
    • Inventor(s)
      岡澤　均
    • Industrial Property Rights Holder
      東京医科歯科大学、デンカ生研株式会社
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Overseas
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Patent] 前頭側頭葉変性症治療剤、前頭側頭葉変性症治療剤のスクリーニング方法、及び前頭側頭葉変性症の治療方法2019
    • Inventor(s)
      岡澤　均
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Overseas
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Patent] ヒトＨＭＧＢ１に特異的に結合するヒトモノクローナル抗体、及びそれを含有するアルツハイマー病を治療又は予防するための医薬組成物2018
    • Inventor(s)
      岡澤　均
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-176802
    • Filing Date
      2018
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Patent] ＭＡＲＣＫＳのリン酸化を指標にしたＡＤ（アルツハイマー病）、ＦＴＬＤ（前頭側頭葉変性症）、ＡＬＳ（筋萎縮性側索硬化症）、ＰＤ（パーキンソン病）およびＤＬＢ（レビー小体型認知症）の検出2018
    • Inventor(s)
      岡澤　均
    • Industrial Property Rights Holder
      東京医科歯科大学、デンカ生研株式会社
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-138785
    • Filing Date
      2018
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Patent] MARKSのリン酸化を指標にしたAD（アルツハイマー病）、FTLD（前頭側頭葉変性症）およびALS（筋萎縮性側索硬化症）の検出2018
    • Inventor(s)
      岡澤　均、デンカ生研
    • Industrial Property Rights Holder
      岡澤　均、デンカ生研
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-043641
    • Filing Date
      2018
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Patent] ｐＳｅｒ４６－ＭＡＲＣＫＳに特異的に結合するモノクローナル抗体の配列2018
    • Inventor(s)
      岡澤　均
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-212340
    • Filing Date
      2018
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Patent] Gas6-Tyro3シグナルを標的とする神経変性の抑制方法2018
    • Inventor(s)
      岡澤　均
    • Industrial Property Rights Holder
      岡澤　均
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Overseas
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Patent] ＨＭＧＢ１抗体によるアルツハイマー病治療2017
    • Inventor(s)
      岡澤　均
    • Industrial Property Rights Holder
      岡澤　均
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Overseas
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Patent] 神経変性疾患タンパク質の異常凝集を伴って発症する神経疾患に対する予防又は治療剤、及び上記予防又は治療剤のスクリーニング方法2016
    • Inventor(s)
      岡澤　均
    • Industrial Property Rights Holder
      国立大学法人東京医科歯科大学　株式会社ペプチド研究所
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-177528
    • Filing Date
      2016-09-12
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Patent] 神経幹細胞の増殖の促進に用いられる製剤、神経幹細胞の減少に関連する疾患の予防又は治療に用いられる製剤（以下略）2016
    • Inventor(s)
      岡澤　均
    • Industrial Property Rights Holder
      国立大学法人東京医科歯科大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-531427
    • Filing Date
      2016-12-27
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Patent] HMGB1に対する抗体、及びそれを含有するアルツハイマー病を治療又は予防するための組成物2016
    • Inventor(s)
      岡澤　均
    • Industrial Property Rights Holder
      国立大学法人東京医科歯科大学　株式会社医学生物学研究所
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-08-09
    • Overseas
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Patent] 神経幹細胞の増殖の促進に用いられる製剤、神経幹細胞の減少に関連する疾患の予防又は治療に用いられる製剤、シナプス後部形成の促進に用いられる製剤、シナプス後部形成の..（以下正式名称備考欄に記載）2015
    • Inventor(s)
      岡澤均
    • Industrial Property Rights Holder
      国立大学法人東京医科歯科大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-07-01
    • Overseas
    • Data Source
      KAKENHI-PROJECT-26640037

  • [Patent] アルツハイマー病及び前頭側頭は変性症の診断方法、診断薬、治療薬、及びこれらの薬剤のスクリーニング方法2014
    • Inventor(s)
      岡澤　均
    • Industrial Property Rights Holder
      岡澤　均
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-12-25
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Patent] 脊髄小脳変性症を予防または治療するための薬剤2014
    • Inventor(s)
      岡澤　均
    • Industrial Property Rights Holder
      岡澤　均
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-10-10
    • Data Source
      KAKENHI-PROJECT-26640037

  • [Patent] アルツハイマー病及び前頭側頭は変性症の診断方法、診断薬、治療薬、及びこれらの薬剤のスクリーニング方法2014
    • Inventor(s)
      岡澤　均
    • Industrial Property Rights Holder
      岡澤　均
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-12-25
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Patent] アルツハイマー病及び前頭側頭葉変性症の診断方法、診断薬、治療薬及びこれらの薬剤スクリーニング法2014
    • Inventor(s)
      岡澤　均
    • Industrial Property Rights Holder
      岡澤　均
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-12-25
    • Data Source
      KAKENHI-PROJECT-26640037

  • [Patent] 脊髄小脳変性症を予防又は治療するための薬剤2014
    • Inventor(s)
      岡澤　均
    • Industrial Property Rights Holder
      岡澤　均
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-10-10
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Patent] 脊髄小脳変性症を予防又は治療するための薬剤2014
    • Inventor(s)
      岡澤　均
    • Industrial Property Rights Holder
      岡澤　均
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-10-10
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Patent] 脊髄小脳変性症１型を予防又は治療するための薬剤2013
    • Inventor(s)
      岡澤　均
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-12-27
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Patent] 脊髄小脳変性症１型を予防又は治療するための薬剤2013
    • Inventor(s)
      岡澤　均
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-12-27
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Patent] アルツハイマー病の診断方法、診断薬、治療薬及びこれら薬剤のスクリーニング方法2013
    • Inventor(s)
      岡澤　均
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-10-11
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Patent] アルツハイマー病の診断方法、診断薬、治療薬及びこれら薬剤のスクリーニング方法2013
    • Inventor(s)
      岡澤　均
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-10-11
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Patent] Prophylactic/Therapeutic Agent for Neurodegenerative Disease2011
    • Inventor(s)
      Hitoshi Okazawa
    • Industrial Property Rights Holder
      National Corporation Tokyo Medical and Dental University
    • Filing Date
      2011-04-24
    • Acquisition Date
      2011-04-27
    • Overseas
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Patent] Prophylactic/Therapeutic Agent for Neurodegenerative Disease2010
    • Inventor(s)
      Hitoshi Okazawa
    • Industrial Property Rights Holder
      National Corporation Tokyo Medical and Dental University
    • Filing Date
      2010-09-17
    • Acquisition Date
      2010-11-16
    • Overseas
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Patent] Prophylactic/therapeutic agent for neurodegenerative disease2009
    • Inventor(s)
      岡澤均
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Filing Date
      2009-11-12
    • Overseas
    • Data Source
      KAKENHI-PROJECT-20023011

  • [Patent] Prophylactic/therapeutic agent for neurodegen erative disease.2009
    • Inventor(s)
      岡澤均
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Filing Date
      2009-11-12
    • Overseas
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Patent] Prophylactic/therapeutic agent for neurodegenerative disease2009
    • Inventor(s)
      岡澤均
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Filing Date
      2009-11-12
    • Overseas
    • Data Source
      KAKENHI-PROJECT-20058010

  • [Patent] 神経変性疾患の予防・治療薬2007
    • Inventor(s)
      岡澤 均
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Filing Date
      2007-04-24
    • Data Source
      KAKENHI-PROJECT-18650097

  • [Patent] PROPHYLACTIC/THERAPEUTIC AGENT FOR NEURODEGENER ATIVE DISEASE OKAZAWA, Hitoshi2007
    • Inventor(s)
      岡澤 均
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Filing Date
      2007-12-06
    • Description
      「研究成果報告書概要(和文)」より
    • Overseas
    • Data Source
      KAKENHI-PROJECT-18390254

  • [Patent] PROPHYLACTIC/THERAPEUTIC AGENT FOR NEURODEGENERATIVE DISEASE OKAZAWA, Hitoshi2007
    • Inventor(s)
      岡澤 均
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Filing Date
      2007-12-06
    • Overseas
    • Data Source
      KAKENHI-PROJECT-18650097

  • [Patent] PROPHYLACTIC/THE RAPEUTIC AGENT FOR NEURODEGENER ATIVE DISEASE OKAZAWA, Hitoshi2007
    • Inventor(s)
      岡澤 均
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Filing Date
      2007-12-06
    • Overseas
    • Data Source
      KAKENHI-PROJECT-18390254

  • [Patent] Prophylactic/Therapeutic Agent for Neurodegenerative Disease2007
    • Inventor(s)
      Hitoshi Okazawa
    • Industrial Property Rights Holder
      National Corporation Tokyo Medical and Dental University
    • Filing Date
      2007-04-24
    • Acquisition Date
      2011-04-27
    • Overseas
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Patent] 神経変性疾患の予防・治療薬2007
    • Inventor(s)
      岡澤 均
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Filing Date
      2007-04-24
    • Data Source
      KAKENHI-PROJECT-18390254

  • [Patent] 神経変性疾患の予防・治療薬2007
    • Inventor(s)
      岡澤 均
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Filing Date
      2007-04-24
    • Data Source
      KAKENHI-PROJECT-18023014

  • [Patent] Prophylactic/Therapeutic Agent for Neurodegenerative Disease2007
    • Inventor(s)
      Hitoshi Okazawa
    • Industrial Property Rights Holder
      National Corporation Tokyo Medical and Dental University
    • Filing Date
      2007-04-24
    • Acquisition Date
      2007-04-27
    • Overseas
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Patent] 精神発達遅滞の非ヒトモデル動物及び精神遅滞の症状を改善する活性を有する物質をスクリーニングする方法2007
    • Inventor(s)
      岡澤 均
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Industrial Property Number
      2007-014795
    • Filing Date
      2007-01-25
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390254

  • [Patent] PROPHYLACTIC/THE RAPEUTIC AGENT FOR NEURODEGENER ATIVE DISEASE OKAZAWA, Hitoshi2007
    • Inventor(s)
      岡澤 均
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Filing Date
      2007-12-06
    • Overseas
    • Data Source
      KAKENHI-PROJECT-18023014

  • [Patent] 神経変性疾患の予防・治療薬2007
    • Inventor(s)
      岡澤 均
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Filing Date
      2007-04-24
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390254

  • [Patent] Preventive or therapeutic agent for neurological disorder.2006
    • Inventor(s)
      OKAZAWA H.
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Filing Date
      2006-01-19
    • Data Source
      KAKENHI-PROJECT-16650076

  • [Patent] Preventive or therapeutio agent for neurological disorder2006
    • Inventor(s)
      OKAZAWA H.
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Filing Date
      2006-01-19
    • Data Source
      KAKENHI-PROJECT-16390249

  • [Patent] Preventive or therapeutic agent for neurological disorder.2006
    • Inventor(s)
      OKAZAWA H.
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Filing Date
      2006-01-19
    • Data Source
      KAKENHI-PROJECT-17025017

  • [Patent] Preventive or therapeutic agent for neurological disorder.2006
    • Inventor(s)
      OKAZAWA H.
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Filing Date
      2006-01-19
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390249

  • [Patent] 神経疾患の予防叉は治療薬2006
    • Inventor(s)
      岡澤 均
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Industrial Property Number
      2006-528482
    • Filing Date
      2006-06-21
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390254

  • [Patent] 神経変性疾患の予防・治療薬2006
    • Inventor(s)
      岡澤 均
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Industrial Property Number
      2006-154059
    • Filing Date
      2006-06-01
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390254

  • [Patent] Gene Encoding a Protein and Preventive/Remedy for Neurodegenerative Diseases such as Polyglutamine Diseases by Utilizing the Same2005
    • Inventor(s)
      Hitoshi Okazawa
    • Industrial Property Rights Holder
      National Corporation Tokyo Medical and Dental University
    • Filing Date
      2005-11-16
    • Acquisition Date
      2011-05-31
    • Overseas
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Patent] Gene Encoding a Protein and Preventive/Remedy for Neurodegenerative Diseases such as Polyglutamine Diseases by Utilizing the Same2005
    • Inventor(s)
      Hitoshi Okazawa
    • Industrial Property Rights Holder
      National Corporation Tokyo Medical and Dental University
    • Filing Date
      2005-11-16
    • Acquisition Date
      2011-05-31
    • Overseas
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Patent] Novel Protein and Preventive/Remedy for Neurodegenerative Disease such as Polyglutamine Disease Using the Same2005
    • Inventor(s)
      Hitoshi Okazawa
    • Industrial Property Rights Holder
      National Corporation Tokyo Medical and Dental University
    • Filing Date
      2005-11-16
    • Acquisition Date
      2011-08-24
    • Overseas
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Patent] Gene Encoding a Protein and Preventive/Remedy for Neurodegenerative Diseases such as Polyglutamine Diseases by Utilizing the Same2005
    • Inventor(s)
      Hitoshi Okazawa
    • Industrial Property Rights Holder
      National Corporation Tokyo Medical and Dental University
    • Filing Date
      2005-11-16
    • Acquisition Date
      2011-05-31
    • Overseas
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Patent] Novel Protein and Preventive/Remedy for Neurodegenerative Disease such as Polyglutamine Disease Using the Same2005
    • Inventor(s)
      Hitoshi Okazawa
    • Industrial Property Rights Holder
      National Corporation Tokyo Medical and Dental University
    • Filing Date
      2005-11-16
    • Acquisition Date
      2011-08-24
    • Overseas
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Patent] Novel Protein and Preventive/Remedy for Neurodegenerative Disease such as Polyglutamine Disease Using the Same2005
    • Inventor(s)
      Hitoshi Okazawa
    • Industrial Property Rights Holder
      National Corporation Tokyo Medical and Dental University
    • Filing Date
      2005-11-16
    • Acquisition Date
      2011-08-24
    • Overseas
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] 動的分子ネットワーク解析を用いたFTLD-AD間における共通コア病態の予測2021
    • Author(s)
      本間 秀典、藤田 慶大、田川 一彦、岡澤 均
    • Organizer
      第13回 CBIR/ONSA/大学院セミナー共催若手インスパイアシンポジウム
    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Presentation] Deciphering and tacking the ultra-early phase pathology of Alzheimer’s disease2021
    • Author(s)
      Hitoshi Okazawa
    • Organizer
      The 15th International Conference on Alzheimer’s and Parkinson’s Diseases
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Presentation] YAP-dependent necrosis occurs in early stages of Alzheimer’s disease and regulates mouse model pathology2020
    • Author(s)
      田中 ひかり、本間 秀典、藤田 慶大、近藤 和、Xiaocen Jin、田川 一彦、岡澤 均
    • Organizer
      第12回 CBIR/ONSA/大学院セミナー共催若手インスパイアシンポジウム
    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Presentation] 神経変性疾患の分子病態2020
    • Author(s)
      岡澤 均
    • Organizer
      横浜市立大学医学部医学科特別講義
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Presentation] 網羅的解析が示唆する変性疾患の超早期病態2020
    • Author(s)
      岡澤　均
    • Organizer
      第23回東京 脳・神経セミナー
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Presentation] YAP-dependent necrosis regulates early stages of Alzheimer’s disease pathology2020
    • Author(s)
      Hikari Tanaka, Hidenori Homma, Kyota Fujita, Kanoh Kondo, Jin Xiaocen, Kazuhiko Tagawa, Hitoshi Okazawa
    • Organizer
      The 43rd Annual Meeting of the Japan Neuroscience Society
    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Presentation] アルツハイマー病態に於ける細胞内アミロイド、細胞死、細胞外アミロイド凝縮の時間的関係2020
    • Author(s)
      岡澤 均
    • Organizer
      第38回日本神経治療学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Presentation] 遺伝子治療によるアルツハイマー治療の可能性2020
    • Author(s)
      岡澤 均
    • Organizer
      第一期バイオインベストメントギルド第9回セミナー
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Presentation] 神経変性疾患の病態に基づく遺伝子治療2020
    • Author(s)
      岡澤　均
    • Organizer
      第2回自治医科大学遺伝子治療研究センター(JMU-CGTR)シンポジウム2020
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Presentation] Discovery of new pathologies and development of new therapeutics based on molecular network analysis against Alzheimer's disease2020
    • Author(s)
      Hitoshi Okazawa
    • Organizer
      The 43rd Annual Meeting of the Japan Neuroscience Society
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Presentation] ハンチントン病の治療開発の動向2020
    • Author(s)
      岡澤 均
    • Organizer
      第61回日本神経学会学術大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Presentation] Phosphorylation of SRRM2 leads to synaptic pathology at ultra-early phase of Alzheimer's disease2020
    • Author(s)
      Hikari Tanaka, Kanoh Kondo, Xigui Chen, Hidenori Homma, Kazuhiko Tagawa, Takaomi Saido, Shin-ichi Muramatsu, Kyota Fujita, Hitoshi Okazawa
    • Organizer
      61st Annual Meeting of the Japanese Society of Neurology
    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Presentation] アルツハイマー病の細胞死は、いつ起きるのか？2020
    • Author(s)
      岡澤　均
    • Organizer
      第42回神経組織培養研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Presentation] YAP依存的ネクローシスは超早期アルツハイマー病態を制御する2020
    • Author(s)
      田中 ひかり、本間 秀典、藤田 慶大、近藤 和、金 暁岑、田川 一彦、岡澤 均
    • Organizer
      第39回日本認知症学会学術集会
    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Presentation] Development of gene therapies of neurodegenerative diseases targeting new pathological mechanisms2020
    • Author(s)
      岡澤　均
    • Organizer
      AMED -Gene & Cell Therapy Symposium－遺伝子・細胞治療シンポジウム－
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Presentation] 発達障害原因遺伝子PQBP1はアルツハイマー病態を制御する2020
    • Author(s)
      田中 ひかり、近藤 和、陳 西貴、本間 秀典、藤田 慶大、田川 一彦、岡澤 均
    • Organizer
      第39回日本認知症学会学術集会
    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Presentation] Research and development of neurodegenerative diseases based on the all Japan Brain Bank Network2019
    • Author(s)
      Hitoshi Okazawa
    • Organizer
      NEURO2019
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Presentation] 認知症の新たな治療戦略と遺伝子治療の可能性2019
    • Author(s)
      岡澤　均
    • Organizer
      第60回日本神経学会学術大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Presentation] Longitudinal radiographic analysis of skeletal development and bone structure in Pqbp1-cKO mice during growth period2019
    • Author(s)
      Shin-Sheng Yang, Takayoshi Ishida, Yuta Nakai, Kyota Fujita, Kazuhiko Tagawa,Takashi Ono, Hitoshi Okazawa
    • Organizer
      日本矯正歯科学会
    • Data Source
      KAKENHI-PROJECT-19K10378

  • [Presentation] New Treatment Strategies in Huntington’s Disease and Other Chorea2019
    • Author(s)
      Hitoshi Okazawa
    • Organizer
      The 6th Asian and Oceanian Parkinson’s Disease and Movement Disorders Congress 2019
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Presentation] Gene therapy for spinocerebellar ataxia2019
    • Author(s)
      Hitoshi Okazawa
    • Organizer
      The 25th Annual Meeting of Japan Society of Gene and Cell Therapy
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Presentation] HMGB1 and Neurodegeneration2019
    • Author(s)
      Hitoshi Okazawa
    • Organizer
      9th International DAMPs and Alarmins Symposium
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Presentation] Alzheimer’s disease and Autophagy2019
    • Author(s)
      Hitoshi Okazawa
    • Organizer
      第38回日本認知症学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Presentation] New therapeutics development against ultra-early phase AD pathology2019
    • Author(s)
      Hitoshi Okazawa
    • Organizer
      第38回日本認知症学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Presentation] Ultra-early phase pathology of neurodegeneration2019
    • Author(s)
      Hitoshi Okazawa
    • Organizer
      China-Japan High-end Forum on Medical and Health Cooperation
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Presentation] アルツハイマー病の遺伝子治療の可能性2019
    • Author(s)
      岡澤　均
    • Organizer
      第24回認知神経科学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Presentation] Ser46-phosphorylated MARCKS is a common mechanism of pre-aggregation neurite degeneration in across multiple dementia2019
    • Author(s)
      Kyota Fujita, Hidenori Homma, Kanoh Kondo, Kazuhiko Tagawa, Hitoshi Okazawa
    • Organizer
      NEURO2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Presentation] アルツハイマー病の新規病態と遺伝子治療法の発見2019
    • Author(s)
      岡澤　均
    • Organizer
      創薬薬理フォーラム第27回シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Presentation] The intellectual disability gene PQBP1 rescues Alzheimer's disease pathology2019
    • Author(s)
      Hikari Tanaka, Kanoh Kondo, Xigui Chen, Hidenori Homma, Kazuhiko Tagawa, Aurelian Kerever, Shigeki Aoki, Takashi Saito, Takaomi Saido, Shin-ichi Muramatsu, Kyota Fujita, Hitoshi Okazawa
    • Organizer
      NEURO2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Presentation] Gene therapy against SCA1 based on the molecular pathomechanism2019
    • Author(s)
      Hitoshi Okazawa
    • Organizer
      60th Annual Meeting Of The Japanese Society of Neurology
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Presentation] Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology2019
    • Author(s)
      Kyota Fujita, Xigui Chen, Hidenori Homma, Kazuhiko Tagawa, Hitoshi Okazawa
    • Organizer
      第60回日本神経学会学術大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Presentation] 発達障害原因遺伝子ＰQBP1はアルツハイマー病態を制御する2019
    • Author(s)
      田中 ひかり、近藤 和、陳 西貴 、本間 秀典、田川 一彦、Aurelian Kerever、青木 茂樹、斉藤 貴志、西道 隆臣、村松 慎一、藤田 慶大、岡澤 均
    • Organizer
      第60回日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Presentation] Targeting HMGB1-mediated expansion of neurodegeneration at the ultra-early phase pathology of Alzheimer’s disease2019
    • Author(s)
      Hitoshi Okazawa
    • Organizer
      AsCNP2019
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H01042

  • [Presentation] 網羅的解析ビッグデータを基盤とする認知症・変性疾患の理解と応用2018
    • Author(s)
      岡澤　均
    • Organizer
      OYCバイオシンポジウム2018
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] New Molecularly Targeted Therapeutics Deduced from Unbiased Approaches2018
    • Author(s)
      Hitoshi Okazawa
    • Organizer
      21st US-Japan Cellular and Gene Therapy Conference.
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] Developmental YAPdeltaC determines adult pathology of spinocerebellar ataxia type 12018
    • Author(s)
      Hitoshi Okazawa
    • Organizer
      the 75th FUJIHARA Seminar
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] アルツハイマー病と前頭側頭葉変性症に共通する異常タウリン酸化とシナプス障害2018
    • Author(s)
      藤田慶大、陳西貴、本間秀典、田川一彦、岡澤均
    • Organizer
      第37回日本認知症学会学術集会
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] Reelin-DBNL signaling regulates neuronal migration via N-cadherin/α -N-catenin complex in the intermediate zone and multipolar cell accumulate zone of the developing mouse cerebral neocortex2018
    • Author(s)
      Seika Inoue, Kanehiro Hayashi, Kyota Fujita, Kazuhiko Tagawa, Hitoshi Okazawa Ken-ichiro Kubo,Kazunori Nakajima,
    • Organizer
      第40回日本生物学的精神医学会・第61 回日本神経化学会大会
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] Developmental YAPdeltaC determines adult pathology in a mouse model of spinocerebellarataxia type 12018
    • Author(s)
      藤田 慶大、毛 瀅、内田 成則、陳 西貴、塩飽 裕紀、田村 拓也、伊藤 日加瑠、本間 秀典、田川 一彦、岡澤 均
    • Organizer
      第59回日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] Symptomatic and Disease Modifying Treatments for Chorea and Huntington’s Disease2018
    • Author(s)
      Hitoshi Okazawa
    • Organizer
      MDS2018 International Congress
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] ＨＭＧＢ１を介した認知症の超早期病態と治療開発2018
    • Author(s)
      岡澤　均
    • Organizer
      第40回日本生物学的精神医学会・第61 回日本神経化学会大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] Comprehensive analyses reveal new concepts of neurodegeneration in time axis2018
    • Author(s)
      Hitoshi Okazawa
    • Organizer
      JNS-JSN Joint Symposium
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] ハンチントン病における新規ネクローシスTRIADの分子病態2018
    • Author(s)
      藤田 慶大、Ying Mao、陳 西貴、山西 恵美子、本間 秀典、田川 一彦、岡澤 均
    • Organizer
      第41回日本神経科学大会
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] 脊髄小脳変性症の遺伝子治療2018
    • Author(s)
      岡澤　均
    • Organizer
      第１回毛細血管拡張性運動失調症（AT）研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] 認知症の超早期病態と新たな治療戦略2018
    • Author(s)
      岡澤　均
    • Organizer
      市民公開講演会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] The hnRNP-Htt axis regulates necrotic cell death induced by transcriptional repression through impaired RNA splicing2018
    • Author(s)
      Hikari Tanaka, Ying Mao, Takuya Tamura, Yoshie Yuki, Daisu Abe, Hidenori Homma,Kazuhiko Tagawa, Hitoshi Okazawa
    • Organizer
      第41回日本神経科学大会
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] HMGB1が仲介するアルツハイマー病の超早期病態2018
    • Author(s)
      岡澤　均
    • Organizer
      岡山大学大学院医歯薬学総合研究科特別講義
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] アルツハイマー病等の認知症に対する新規治療法開発2018
    • Author(s)
      岡澤　均
    • Organizer
      技術情報協会　認知症セミナー（認知症の早期診断と進行抑制薬開発へのポイント）
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] Novel Hippo pathway-dependent necrosis, TRIAD and Huntington’s disease2018
    • Author(s)
      Hitoshi Okazawa
    • Organizer
      ICN 2018 Tokyo
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] Comprehensive proteome analysis reveals ultra-early phase pathologies of neurodegenerative diseases2018
    • Author(s)
      Hitoshi Okazawa
    • Organizer
      ICN 2018 Tokyo
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] 慢性脳低灌流がアルツハイマー病における脳内アミロイドβ蓄積を増加させる機序の解明2018
    • Author(s)
      坂内太郎、間野達雄、陳西貴、大友亮、大友岳、橋本唯史、岡澤均、岩坪威、戸田達史、岩田淳
    • Organizer
      第37回日本認知症学会学術集会
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] Developmental YAPdeltaC determines adult　pathology in a model of spinocerebellar ataxia type 12018
    • Author(s)
      Kazuhiko Tagawa, Kyota Fujita Ying Mao, Shigenori Uchida, Xigui Chen, Kei Watase, Hidenori Homma, Marius Sudol, Hitoshi Okazawa
    • Organizer
      第41回日本神経科学大会
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] In vivo imaging of intracellular organelle in neurons of Alzheimer's disease and other neurodegenerative disease model2018
    • Author(s)
      Kanoh Kondo, Xigui Chen, Kazumi Motoki, Hidenori Homma, Hitoshi Okazawa
    • Organizer
      第41回日本神経科学大会
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] 網羅的分子ネットワーク解析が紐解く新たな神経変性病態と治療応用2018
    • Author(s)
      岡澤　均
    • Organizer
      第55回日本臨床分子医学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] 神経変性疾患の超早期病態の解明に向けて2018
    • Author(s)
      岡澤　均
    • Organizer
      第23回山梨神経先端セミナー
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] Common pathologies across multiple neurodegenerative diseases revealed from unbiased approaches2017
    • Author(s)
      Hitoshi Okazawa
    • Organizer
      MyNEURO 2017
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer's disease2017
    • Author(s)
      Kyota Fujita, Kazumi Motoki, Kazuhiko Tagawa, Xigui Chen, Hiroshi Hama, Kazuyuki Nakajima, Hidenori Homma, Takuya Tamura, Masahisa Katsuno, Takashi Saito, Takaomi Saido, Gen Sobue, Atsushi Miyawaki, Hitoshi Okazawa
    • Organizer
      第40回日本神経科学大会
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] Hippoシグナル依存的な新規ネクローシス“TRIAD”と神経変性2017
    • Author(s)
      岡澤　均
    • Organizer
      第26回日本Cell Death学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] Targeting TEAD/YAP-transcription-dependent necrosis, TRIAD, ameliorates Huntington's disease pathology2017
    • Author(s)
      Mao Ying, Xigui Chen, Xu Min, Kyota Fujita, Kazumi Motoki, Toshikazu Sasabe, Hidenori Homma, Miho Murata, Kazuhiko Tagawa, Takuya Tamura, Kaye Julia, Steven Finkbeiner, Giovanni Blandino, Marius Sudol, Kanoh Kondo, Hitoshi Okazawa.
    • Organizer
      第58回日本神経学会学術大会・第23回世界神経学会議
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] Effect of specific inhibition of synaptic delivery of APP by loss-of-function of yata on the Drosophila Alzheimer's disease model2017
    • Author(s)
      Masaki Sone, Koto Furotani, Taka-aki Yajima, Takuya Tamura, Hitoshi Okazawa
    • Organizer
      第40回日本神経科学大会
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] Impaired DNA Damage Repair in SCA1 and Other CAG Repeat Diseases2017
    • Author(s)
      Hitoshi Okazawa
    • Organizer
      Gordon Research Conference
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] HMGB1 and Neurodegeneration2017
    • Author(s)
      Hitoshi Okazawa
    • Organizer
      8th International DAMPs and Alarmins Symposium (iDEAs)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] Targeting TEAD/YAP-transcription-dependent necrosis, TRIAD, ameliorates Huntington's disease pathology2017
    • Author(s)
      Mao Ying, Xigui Chen, Xu Min, Kyota Fujita, Kazumi Motoki, Toshikazu Sasabe, Hidenori Homma, Miho Murata, Kazuhiko Tagawa, Takuya Tamura, Kaye Julia, Steven Finkbeiner, Giovanni Blandino, Marius Sudol, Kanoh Kondo, Hitoshi Okazawa
    • Organizer
      第40回日本神経科学大会
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] Conceptual merge between aging and neurodegeneration2017
    • Author(s)
      Hitoshi Okazawa
    • Organizer
      第16回駿河台シンポジウム/第8回難治疾患共同研究拠点シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] HMGB1 TRIGGERS NEURITE DEGENERATION VIA TLR4-MARCKS, AND IS A POTENTIAL THERAPEUTIC TARGET FOR ALZHEIMER’S DISEASE.2017
    • Author(s)
      Kyota Fujita, Kazumi Motoki, Kazuhiko Tagawa, Xigui Chen, Hiroshi Hama, Kazuyuki Nakajima, Hidenori Homma, Takuya Tamura, Atsushi Miyawaki, Hitoshi Okazawa
    • Organizer
      World Congress of Neurology (WCN 2017)
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] Common pathologies across multiple neurodegenerative diseases revealed from unbiased approaches2017
    • Author(s)
      岡澤　均
    • Organizer
      第12回研究所ネットワーク国際シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] Gene Therapy Against Spinocerebellar Ataxia2017
    • Author(s)
      Hitoshi Okazawa
    • Organizer
      XXIII World Congress of Neurology (WCN2017）
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] ポリグルタミン病の共通病態を基盤とする分子標的治療の開発2017
    • Author(s)
      岡澤　均
    • Organizer
      第32回日本大脳基底核研究会（JBAGS2017）
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] yata機能欠損によるAPPシナプス輸送の特異的阻害によるショウジョウバエアルツハイマー病モデルの病態回復2017
    • Author(s)
      曽根雅紀、風呂谷航人、矢島隆明、田村拓也、岡澤均
    • Organizer
      第40回日本神経科学大会
    • Place of Presentation
      幕張メッセ（千葉県千葉市）
    • Year and Date
      2017-07-21
    • Data Source
      KAKENHI-PROJECT-26350982

  • [Presentation] RpA1 ameliorates symptoms of mutant ataxin-1 knock-in mice and enhances DNA damage repair2017
    • Author(s)
      Juliana Bosso Taniguchi, Kanoh Kondo, Kyota Fujita, Chen Xigui, Hidenori Homma, Takeaki Sudo,Ying Mao, Kei Watase, Toshihiro Tanaka, Kazuhiko Tagawa, Takuya Tamura, Shin-Ichi Muramatsu, Hitoshi Okazawa
    • Organizer
      第40回日本神経科学大会
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] HMGB1によるミトコンドリア修復機能および遺伝子治療への展開2017
    • Author(s)
      岡澤　均
    • Organizer
      AMEDミトコンドリアシンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] RPA1 AMELIORATES SYMPTOMS OF MUTANT ATAXIN-1 KNOCK-IN MICE AND ENHANCE DNA DAMAGE REPAIR2017
    • Author(s)
      Juliana Bosso Taniguchi, Kanoh Kondo, Kyota Fujita, Xigui Chen, Hidenori Homma , Ying Mao , Kazuhiko Tagawa , Hitoshi Okazawa
    • Organizer
      第58回日本神経学会学術大会・第23回世界神経学会議
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] 認知症治療の最前線：超早期病態へのアプローチ2017
    • Author(s)
      岡澤　均
    • Organizer
      第18回市民公開講座
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] 「SCAに対する新規遺伝子治療法の開発」2016
    • Author(s)
      岡澤　均
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸国際展示場（兵庫県神戸市）
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] “Gene therapy to conquer spinocerebellar ataxia”2016
    • Author(s)
      Hitoshi Okazawa
    • Organizer
      第22回日本遺伝子細胞治療学会 (JSGCT2016)
    • Place of Presentation
      虎の門ヒルズフォーラム（東京）
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] “Interaction of spliceosomal proteins PQBP1, U5-15kD, and WBP11”2016
    • Author(s)
      Mineyuki Mizuguchi, Yuko Nabeshima, Takayuki Obita, Hitoshi Okazawa.
    • Organizer
      The XXVIIth International Conference on Magnetic Resonance in Biological Systems.
    • Place of Presentation
      International Conference Center Kyoto （京都府京都市）
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] yata機能欠損によるAPPシナプス輸送阻害のショウジョウバエアルツハイマー病モデルへの効果2016
    • Author(s)
      風呂谷航人、矢島隆明、田村拓也、岡澤均、曽根雅紀
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜（神奈川県横浜市）
    • Year and Date
      2016-07-20
    • Data Source
      KAKENHI-PROJECT-26350982

  • [Presentation] “Fasting activates macroautophagy in neurons of AD mice but is insufficient to degrade amyloid-beta”2016
    • Author(s)
      Xigui Chen, Kanoh Kondo, Kazumi Motoki, Hidenori Homma, Hitoshi Okazawa.
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸国際展示場（兵庫県神戸市）
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] “Effect of inhibition of synaptic delivery of APP by loss-of-function of yata for the Drosophila Alzheimer's disease model”2016
    • Author(s)
      Koto Furotani, Takaaki Yajima, Motoharu Toyokawa, Minoru Nakayama, Takuya Tamura, Hitoshi Okazawa, Masaki Sone.
    • Organizer
      第12回日本ショウジョウバエ研究会
    • Place of Presentation
      立教大学（東京）
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] 「変性型認知症の分子メカニズムの共通性と特異性」2016
    • Author(s)
      岡澤　均
    • Organizer
      第35回日本認知症学会学術集会
    • Place of Presentation
      東京国際フォーラム（東京）
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] yata機能欠損によるAPPシナプス輸送阻害のショウジョウバエアルツハイマー病モデルへの効果2016
    • Author(s)
      風呂谷航人、矢島隆明、豊川誉陽、中山実、田村拓也、岡澤均、曽根雅紀
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜（神奈川県横浜市）
    • Year and Date
      2016-12-01
    • Data Source
      KAKENHI-PROJECT-26350982

  • [Presentation] “Effect of inhibition of synaptic delivery of APP by the loss-of-function mutation of yata for the Drosophila Alzheimer's disease model”2016
    • Author(s)
      Koto Furotani, Takaaki Yajima, Motoharu Toyokawa, Minoru Nakayama, Takuya Tamura, Hitoshi Okazawa, Masaki Sone.
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜（神奈川県横浜市）
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] Systematic Analysis of Fly Models Elucidates Sleep disturbance in Huntington’s Disease”2016
    • Author(s)
      Takuya Tamura, Risa Shiraishi, Masaki Sone, Hitoshi Okazawa.
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸国際展示場（兵庫県神戸市）
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] Effect of inhibition of synaptic delivery of APP by loss-of-function of yata for the Drosophila Alzheimer's disease model.2016
    • Author(s)
      Koto Furotani, Takaaki Yajima, Motoharu Toyokawa, Minoru Nakayama, Takuya Tamura, Hitoshi Okazawa, Masaki Sone
    • Organizer
      日本ショウジョウバエ研究会第12回研究集会
    • Place of Presentation
      立教大学（東京都豊島区）
    • Year and Date
      2016-09-09
    • Data Source
      KAKENHI-PROJECT-26350982

  • [Presentation] “Analysis of molecular mechanism and development of therapeutic methods in spinocerebellar ataxia type 1 (SCA1)”2016
    • Author(s)
      Hikaru Ito, Kyota Fujita, Xigui Chen, Hitoshi Okazawa.
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸国際展示場（兵庫県神戸市）
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] “Fasting activates macroautophagy in neurons of Alzheimer’s disease mice but is insufficient to degrade amyloid-beta”2016
    • Author(s)
      Xigui Chen, Kanoh Kondo, Kazumi Motoki, Hidenori Homma, Hitoshi Okazawa.
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜（神奈川県横浜市）
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02655

  • [Presentation] Comprehensive phosphoproteome analysis in preclinical Alzheimer's disease brain2015
    • Author(s)
      田川 一彦、本間 秀典、斉藤 あゆむ、村山 繁雄、岩坪 威、宮野 悟、岡澤 均
    • Organizer
      第56回日本神経学会学術大会
    • Place of Presentation
      朱鷺メッセ（新潟コンベンションセンター）/ホテル日航新潟（新潟県新潟市）
    • Year and Date
      2015-05-21
    • Data Source
      KAKENHI-PROJECT-26640037

  • [Presentation] HMGB1 gene therapy ameliorates phenotype of mutant ataxin-1 knock-in mice2015
    • Author(s)
      伊藤 日加瑠、藤田 慶大、田川 一彦、陳 西貴、本間 秀典、笹邊 俊和、清水 潤、清水 重臣、村松 慎一、岡澤 均
    • Organizer
      第56回日本神経学会学術大会
    • Place of Presentation
      朱鷺メッセ（新潟コンベンションセンター）/ホテル日航新潟（新潟県新潟市）
    • Year and Date
      2015-05-21
    • Data Source
      KAKENHI-PROJECT-26640037

  • [Presentation] 「早期アルツハイマー病脳における網羅的リン酸化プロテオーム解析」2015
    • Author(s)
      田川 一彦、本間 秀典、斉藤 あゆむ、村山 繁雄、岩坪 威、宮野 悟、岡澤 均
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      第38回日本神経科学大会
    • Year and Date
      2015-07-30
    • Data Source
      KAKENHI-PROJECT-26640037

  • [Presentation] 「早期アルツハイマー病脳における網羅的リン酸化プロテオーム解析」2015
    • Author(s)
      田川 一彦、本間 秀典、斉藤 あゆむ、村山 繁雄、岩坪 威、宮野 悟、岡澤 均
    • Organizer
      第56回日本神経病理学会総会学術研究会
    • Place of Presentation
      九州大学医学部百年講堂（福岡県福岡市）
    • Year and Date
      2015-06-04
    • Data Source
      KAKENHI-PROJECT-26640037

  • [Presentation] 「早期アルツハイマー病モデルマウス脳における網羅的リン酸化プロテオーム解析」2015
    • Author(s)
      田川 一彦、本間 秀典、斉藤 あゆむ、藤田 慶大、陳 西貴、村山 繁雄、岩坪 威、宮野 悟、岡澤 均
    • Organizer
      第34回日本認知症学会学術集会
    • Place of Presentation
      リンクステーションホール青森/ホテル青森（青森県青森市）
    • Year and Date
      2015-10-02
    • Data Source
      KAKENHI-PROJECT-26640037

  • [Presentation] In utero treatment for PQBP-1 gene mutations2015
    • Author(s)
      Hitoshi Okazawa
    • Organizer
      10th International Meeting on Copy Number Variants and Genes in Intellectual Disability and Autism.
    • Place of Presentation
      La Cittadella dell'Oasi (Troina, Italy)
    • Year and Date
      2015-04-16
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26640037

  • [Presentation] シナプス病態から脳疾患治療へ、網羅的質量分析の示唆するアルツハイマー病のシナプス超早期病態の分子機構2014
    • Author(s)
      岡澤 均
    • Organizer
      包括脳ネットワーク』冬のシンポジウム「精神神経疾患研究の現状と展望：新学術５領域の相互理解･連携を目指して」
    • Place of Presentation
      東京
    • Year and Date
      2014-12-11
    • Invited
    • Data Source
      KAKENHI-PROJECT-26640037

  • [Presentation] Systems biology analysis of Drosophila in vivo screen data elucidates core networks for DNAdamage repair in SCA1.2014
    • Author(s)
      Takuya Tamura, Sam S. Berclay, Kyota Fujita, Hikaru Ito, Kazumi Motoki, Teppei Shimamura, Kazuhiko Tagawa, Asuka Katsuta, Hiroki Shiwaku, Masaki Sone, Seiya Imoto, Satoru Miyano, Hitoshi Okazawa
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜（神奈川県横浜市）
    • Year and Date
      2014-09-13
    • Data Source
      KAKENHI-PROJECT-26350982

  • [Presentation] 複数のポリグルタミン病に共通するTERA/VCP/p97のDNA損傷修復機能不全2014
    • Author(s)
      藤田慶大、中村蓉子、岡努、伊藤日加瑠、田村拓也、田川一彦、笹邊俊和、勝田明寿香、本木和美、塩飽裕紀、吉田千里、曽根雅紀、岡澤 均
    • Organizer
      第55回日本神経病理学会総会学術研究会
    • Place of Presentation
      学術総合センター（東京都千代田区）
    • Year and Date
      2014-06-06
    • Data Source
      KAKENHI-PROJECT-26350982

  • [Presentation] 複数のポリグルタミン病におけるTERA/VCP/p97 のDNA 損傷修復機能不全2014
    • Author(s)
      藤田慶太, 中村蓉子, 岡努, 伊藤日加瑠, 田村拓也, 田川一彦, 笹邊俊和, 勝田明寿香, 本木和美, 塩飽裕樹, 曽根雅紀, 吉田千里, 岡澤均
    • Organizer
      第6回CBIR 若手インスパイアシンポジウム
    • Place of Presentation
      東京医科歯科大学(東京都文京区)
    • Year and Date
      2014-02-02
    • Data Source
      KAKENHI-PROJECT-23500401

  • [Presentation] TERA/VCP/p97のDNA修復機能不全は複数の神経変性疾患に関与する2014
    • Author(s)
      藤田慶大、中村蓉子、岡努、伊藤日加瑠、田村拓也、田川一彦、笹邊俊和、勝田明寿香、本木和美、塩飽裕紀、吉田千里、曽根雅紀、岡澤均
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      福岡国際会議場（福岡県福岡市）
    • Year and Date
      2014-05-23
    • Data Source
      KAKENHI-PROJECT-26350982

  • [Presentation] 脊髄小脳変性症I 型の病態を制御するDNA 損傷修復機構2014
    • Author(s)
      田村拓也, Sam S. Berclay, 藤田慶太, 伊藤日加瑠, 本木和美, 島村徹平, 田川一彦, 勝田明寿香, 曽根雅紀, 井元清哉, 宮野悟, 岡澤均
    • Organizer
      第6回CBIR 若手インスパイアシンポジウム
    • Place of Presentation
      東京医科歯科大学(東京都文京区)
    • Year and Date
      2014-02-02
    • Data Source
      KAKENHI-PROJECT-23500401

  • [Presentation] 脊髄小脳失調症1 型におけるDNA損傷修復異常のコアネットワーク解析2014
    • Author(s)
      田村拓也、Barclay S Sam、藤田慶大、伊藤日加瑠、本木和美、島村徹平、田川一彦、勝田明寿香、曽根雅紀、井元清哉、宮野悟、岡澤均
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      福岡国際会議場（福岡県福岡市）
    • Year and Date
      2014-05-23
    • Data Source
      KAKENHI-PROJECT-26350982

  • [Presentation] A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiplepolyglutamine diseases.2014
    • Author(s)
      Kyota Fujita, Yoko Nakamura, Tsutomu Oka, Hikaru Ito, Takuya Tamura, Kazuhiko Tagawa, Toshikazu Sasabe, Asuka Katsuta, Kazumi Motoki, Hiroki Shiwaku, Chisato Yoshida, Masaki Sone, Hitoshi Okazawa
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜（神奈川県横浜市）
    • Year and Date
      2014-09-12
    • Data Source
      KAKENHI-PROJECT-26350982

  • [Presentation] 脊髄小脳失調症1 型におけるDNA損傷修復異常のコアネットワーク解析2014
    • Author(s)
      田村拓也、Barclay S Sam、藤田慶大、伊藤日加瑠、本木和美、島村徹平、田川一彦、勝田明寿香、曽根雅紀、井元清哉、宮野悟、岡澤均
    • Organizer
      第55回日本神経病理学会総会学術研究会
    • Place of Presentation
      学術総合センター（東京都千代田区）
    • Year and Date
      2014-06-06
    • Data Source
      KAKENHI-PROJECT-26350982

  • [Presentation] 昆虫モデルから見る神経疾患の特異性と普遍性2014
    • Author(s)
      田村拓也、岡澤均
    • Organizer
      第7回分子高次機能研究会
    • Place of Presentation
      KKR沼津はまゆう（静岡県沼津市）
    • Year and Date
      2014-08-25
    • Data Source
      KAKENHI-PROJECT-26350982

  • [Presentation] 脊髄小脳変性症1型の分子病態コアネットワークの解明2014
    • Author(s)
      田村拓也、Barclay S Sam、藤田慶大、伊藤日加瑠、本木和美、島村徹平、田川一彦、勝田明寿香、曽根雅紀、井元清哉、宮野悟、岡澤均
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜（神奈川県横浜市）
    • Year and Date
      2014-11-26
    • Data Source
      KAKENHI-PROJECT-26350982

  • [Presentation] 脊髄小脳失調症1型における複製依存的DNA修復の関与2014
    • Author(s)
      田村　拓也、岡澤　均
    • Organizer
      運動失調症の病態解明と治療法開発に関する研究班 平成25年度班会議
    • Place of Presentation
      都市センターホテル東京
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Presentation] ”Comprehensive Phosphoproteome Analysis Unravels the Core Signaling Network that Initiates the Earliest Synapse Pathology in Preclinical Alzheimer’s Disease Brain”2014
    • Author(s)
      Okazawa, H.
    • Organizer
      ISP Symposium 2014
    • Place of Presentation
      Tokyo
    • Year and Date
      2014-08-28
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] ショウジョウバエアルツハイマー病モデルにおけるyata遺伝子によるAPP輸送制御2014
    • Author(s)
      矢島隆明、田村拓也、岡澤均、曽根雅紀
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜（神奈川県横浜市）
    • Year and Date
      2014-11-25
    • Data Source
      KAKENHI-PROJECT-26350982

  • [Presentation] Comprehensive Phosphoproteome Analysis Unravels the Core Signaling Network that Initiates the Earliest Synapse Pathology in Preclinical Alzheimer’s Disease Brain2014
    • Author(s)
      Okazawa, H.
    • Organizer
      ISP Symposium 2014
    • Place of Presentation
      Tokyo
    • Year and Date
      2014-08-28
    • Invited
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Presentation] Comprehensive Phosphoproteome Analysis Unravels the Core Signaling Network that Initiates the Earliest Synapse Pathology in Preclinical Alzheimer’s Disease Brain2014
    • Author(s)
      Okazawa, H.
    • Organizer
      ISP Symposium 2014
    • Place of Presentation
      Tokyo
    • Year and Date
      2014-08-28
    • Invited
    • Data Source
      KAKENHI-PROJECT-26640037

  • [Presentation] 脊髄小脳失調症１型における複製依存的DNA修復の関与2014
    • Author(s)
      田村　拓也、岡澤　均
    • Organizer
      運動失調症の病態解明と治療法開発に関する研究班　平成25年度班会議
    • Place of Presentation
      都市センターホテル東京
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] Morphological and molecular changes of synaptic spines in mouse models of PQBP1-linked intellectual disability.2013
    • Author(s)
      Okazawa, H.
    • Organizer
      The 16th International Workshop on Fragile X
    • Place of Presentation
      Novotel Barossa Valley Resort, Australia
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] 複数のポリグルタミン病におけるTERRA/VCP/p97のDNA損傷修復機能不全2013
    • Author(s)
      藤田　慶大、中村　蓉子、岡　努、伊藤　日加瑠、田村　拓也、田川　一彦、笹邊　俊和、勝田　明寿香、本木　和美、塩飽　裕紀、曽根　雅紀、吉田　千里、岡澤　均
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] 脊髄小脳変性症I 型におけるDNA 損傷修復遺伝子の効果 : in vivo screening による解析2013
    • Author(s)
      田村拓也, Sam Barclay, 藤田慶太, 伊藤日加瑠, 本木和美, 島村徹平, 勝田明寿香, 塩飽裕樹, 曽根雅紀, 田川一彦, 井元清哉, 宮野悟, 岡澤均
    • Organizer
      第5回CBIR 若手インスパイアシンポジウム
    • Place of Presentation
      東京医科歯科大学(東京都文京区)
    • Year and Date
      2013-02-23
    • Data Source
      KAKENHI-PROJECT-23500401

  • [Presentation] HMGB1 as a therapeutic molecule candidate for spinocerebellar ataxia type1 (SCA1).2013
    • Author(s)
      Ito, H., Tagawa, K., Okazawa, H.
    • Organizer
      Neuro2013
    • Place of Presentation
      Kyoto International Conference Center
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] 神経変性疾患モデルショウジョウバエを用いたバイオインフォマティック解析2013
    • Author(s)
      田村　拓也　岡澤　均
    • Organizer
      第六回高次分子機能研究会
    • Place of Presentation
      軽井沢ホテル
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Presentation] 複数のポリグルタミン病におけるTERA/VCP/p97のDNA損傷修復機能不全2013
    • Author(s)
      藤田　慶大、中村　蓉子、岡努、伊藤　日加瑠、田村　拓也、田川　一彦、笹邊俊和、勝田　明寿香、本木　和美、塩飽　裕紀、曽根　雅紀、吉田　千里、岡澤　均
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Presentation] 神経疾患タンパク質研究とブレインバンク2013
    • Author(s)
      岡澤　均
    • Organizer
      第54回日本神経病理学会学術研究会　シンポジウム・ブレインバンク
    • Place of Presentation
      タワーホール船堀、東京
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] HMGB1を用いた脊髄小脳変性症１型モデルマウス治療の試み2013
    • Author(s)
      伊藤　日加瑠、田川　一彦、岡澤　均
    • Organizer
      第54回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] 神経疾患タンパク質研究とブレインバンク2013
    • Author(s)
      岡澤　均
    • Organizer
      第５４回日本神経病理学会総会学術研究会 シンポジウム・ブレインバンク
    • Place of Presentation
      タワーホール船堀、東京
    • Invited
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Presentation] Causative pathway underlying in spinocellebelar ataxia type 12013
    • Author(s)
      Takuya Tamura, Sam. S. Berclay, Kyota Fujita, Hikaru Ito, Kazumi Motoki, Teppei Shimamura , Kazuhiko Tagawa , Asuka Katsuta, Masaki Sone, Seiya Imoto, Satoru Miyano , Hitoshi Okazawa
    • Organizer
      第36回日本神経科学大会・第56回日本神経化学会大会・第23回日本神経回路学会大会合同年会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2013-06-20
    • Data Source
      KAKENHI-PROJECT-23500401

  • [Presentation] 複数のポリグルタミン病におけるTERA/VCP/p97 のDNA 損傷修復機能不全2013
    • Author(s)
      藤田慶太, 中村蓉子, 岡努, 伊藤日加瑠, 田村拓也, 田川一彦, 笹邊俊和, 勝田明寿香, 本木和美, 塩飽裕樹, 曽根雅紀, 吉田千里, 岡澤均
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸国際会議場, 神戸国際展示場, 神戸ポートピアホテル(兵庫県神戸市)
    • Year and Date
      2013-12-04
    • Data Source
      KAKENHI-PROJECT-23500401

  • [Presentation] Morphological and molecular changes of synaptic spines in mouse models of PQBP1-linked intellectual disability.2013
    • Author(s)
      Okazawa,H.
    • Organizer
      The 16th International Workshop on Fragile X
    • Place of Presentation
      Nobvotel Barossa Valley Resort, Australia
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Presentation] TERA/VCP/p97 のDNA 修復機能不全は複数の神経変性疾患に関与する2013
    • Author(s)
      藤田慶太, 中村蓉子, 岡努, 伊藤日加瑠, 田村拓也, 田川一彦, 岡澤均
    • Organizer
      第32回日本認知症学会学術集会
    • Place of Presentation
      キッセイ文化ホール・松本市総合体育館(長野県松本市)
    • Year and Date
      2013-11-09
    • Data Source
      KAKENHI-PROJECT-23500401

  • [Presentation] 脊髄小脳変性症1 型におけるDNA損傷修復遺伝子の効果;in vivo screeningによる解析2013
    • Author(s)
      田村 拓也、Barclay S Sam、藤田 慶大、伊藤 日加瑠、本木 和美、島村 徹平、田川 一彦、勝田 明寿香、曽根 雅紀、井元 清哉、宮野 悟、岡澤 均
    • Organizer
      第５４回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Presentation] TERA/VCP/p97のDNA修復機能不全は複数の神経変性疾患に関与する2013
    • Author(s)
      藤田　慶大、中村　蓉子、岡　努、伊藤　日加瑠、田村　拓也、田川　一彦、岡澤　均
    • Organizer
      第32回日本認知症学会学術集会
    • Place of Presentation
      キッセイ文化ホール、松本
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Presentation] Brain disease researches and brain bank.2013
    • Author(s)
      Okazawa,H.
    • Organizer
      Neuro2013
    • Place of Presentation
      Kyoto International Conference Centeｒ
    • Invited
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Presentation] HMGB1を用いた脊髄小脳失調症１型モデルマウス治療の試み2013
    • Author(s)
      伊藤　日加瑠、田川　一彦、岡澤　均
    • Organizer
      第５４回日本神経病理学会総会学術研究会
    • Place of Presentation
      タワーホール船堀、東京
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Presentation] TERA/VCP/p97のDNA修復機能不全は複数の神経変性疾患に関与する2013
    • Author(s)
      藤田　慶大、中村　蓉子、岡　努、伊藤　日加瑠、田村　拓也、田川　一彦、岡澤　均
    • Organizer
      第32回日本認知症学会学術集会
    • Place of Presentation
      キッセイ文化ホール、長野
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] 神経変性疾患モデルショウジョウバエを用いたバイオインフォマティック解析2013
    • Author(s)
      田村拓也　岡澤　均
    • Organizer
      第6回高次分子機能研究会
    • Place of Presentation
      軽井沢ホテル
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] 脊髄小脳変性症１型におけるDNA損傷修復遺伝子の効果；in vivo screeningによる解析2013
    • Author(s)
      田村　拓也、Barclay S Sam、藤田　慶大、伊藤　日加瑠、本木　和美、島村　徹平、田川　一彦、勝田　明寿香、曽根　雅紀、井元　清哉、宮野　悟、岡澤　均
    • Organizer
      第54回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] HMGB1 as a therapeutic molecule candidate for spinocerebellar ataxia type1 (SCA1).2013
    • Author(s)
      Ito, H., Tagawa, K., Okazawa, H.
    • Organizer
      Neuro2013
    • Place of Presentation
      Kyoto International Conference Centeｒ
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Presentation] Replication-dependent DNA repair in SCA1 pathology.2013
    • Author(s)
      Tamura, T., Barclay, S, S., Fujita, K., Ito, H., Motoki, K., Shimamura, T., Tagawa, K., Katsuta, A., Shiwaku, H., Sone, M., Tagawa, K., Imoto, S., Miyano, S., Okazawa, H.
    • Organizer
      Neuro2013
    • Place of Presentation
      Kyoto International Conference Center
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] Sox2 transcriptionally regulates PQBP1, an intellectural disability-microcephary causative gene, in neural stem progenitor cells2013
    • Author(s)
      Chen Li, Hikaru Ito, Kyota Fujita, Hiroki Shiwaku, Yunglong Qi, Kazuhiko Tagawa, Takuya Tamura, Hitoshi Okazawa
    • Organizer
      第5回CBIR 若手インスパイアシンポジウム
    • Place of Presentation
      東京医科歯科大学(東京都文京区)
    • Year and Date
      2013-02-23
    • Data Source
      KAKENHI-PROJECT-23500401

  • [Presentation] Replication-dependent DNA repair in SCA1 pathology.2013
    • Author(s)
      Tamura, T., Barclay, S, S., Fujita, K., Ito, H., Motoki, K., Shimamura, T., Tagawa, K., Katsuta, A., Shiwaku, H., Sone, M., Tagawa, K., Imoto, S., Miyano, S., Okazawa, H.
    • Organizer
      Neuro2013
    • Place of Presentation
      Kyoto International Conference Centeｒ
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Presentation] 脊髄小脳変性症I 型におけるDNA 損傷修復遺伝子の効果 : in vivo スクリーニングによる解析2013
    • Author(s)
      田村拓也, Sam S. Berclay, 藤田慶太, 伊藤日加瑠, 本木和美, 島村徹平, 田川一彦, 勝田明寿香, 曽根雅紀, 井元清哉, 宮野悟, 岡澤均
    • Organizer
      第54回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2013-05-30
    • Data Source
      KAKENHI-PROJECT-23500401

  • [Presentation] HMGB1を用いた脊髄小脳失調症１型モデルマウス治療の試み2013
    • Author(s)
      伊藤　日加瑠、田川　一彦、岡澤　均
    • Organizer
      第54回日本神経病理学会総会学術研究会
    • Place of Presentation
      タワーホール船堀、東京
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] Brain disease researches and brain bank2013
    • Author(s)
      Okazawa, H.
    • Organizer
      Neuro2013
    • Place of Presentation
      Kyoto International Conference Center
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] HMGB1を用いた脊髄小脳変性症１型モデルマウス治療への試み2013
    • Author(s)
      伊藤　日加瑠、田川　一彦、岡澤　均、
    • Organizer
      第５４回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Presentation] PQBP1遺伝子発現量と症状の相関関係2012
    • Author(s)
      田村拓也、中村蓉子、塩飽裕紀、岡澤均
    • Organizer
      第31回日本認知症学会学術集会
    • Place of Presentation
      つくば国際会議場（茨城県）
    • Data Source
      KAKENHI-PROJECT-23500401

  • [Presentation] New Common Pathologies of Neurodegenerative Diseases2012
    • Author(s)
      岡澤均
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場　名古屋
    • Year and Date
      2012-09-18
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] DNA 修復タンパク質・Ku70 はハンチントン病の神経変性を抑制する2012
    • Author(s)
      田村拓也, 曽根雅紀, 岩坪威, 田川一彦, Erich Wanker, 岡澤均
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2012-05-24
    • Data Source
      KAKENHI-PROJECT-23500401

  • [Presentation] ポリグルタミン病の分子標的治療の開発に向けて2012
    • Author(s)
      岡澤均
    • Organizer
      パソシグナリングバイオロジー　ワークショップ
    • Place of Presentation
      東京医科歯科大学　東京
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] 核内・核近傍の分子を標的とした神経変性疾患モデルショウジョウバエ研究2012
    • Author(s)
      曽根雅紀, 田村拓也, 岩坪威, 岡澤均
    • Organizer
      東京医科歯科大学・第3回難治疾患共同研究拠点シンポジウム
    • Place of Presentation
      東京医科歯科大学(東京都文京区)
    • Year and Date
      2012-07-31
    • Invited
    • Data Source
      KAKENHI-PROJECT-23500401

  • [Presentation] Pathomechanisms of Intellectual Disabilities linked to a new RNA splicing protein,PQBP1.2012
    • Author(s)
      Okazawa H
    • Organizer
      Tokyo Medical and Dental University International Summer Program 2012
    • Place of Presentation
      Tokyo Medical and Dental University,MD Tower,Akio Suzuki Memorial Hall
    • Year and Date
      2012-08-27
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] 発現量依存的に寿命をコントロールする遺伝子, PQBP12012
    • Author(s)
      田村拓也, 曽根雅紀, 中村蓉子, 島村徹平, 井元清哉, 宮野悟, 岡澤均
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場・マリンメッセ福岡(福岡県福岡市)
    • Year and Date
      2012-12-14
    • Data Source
      KAKENHI-PROJECT-23500401

  • [Presentation]2012
    • Author(s)
      田村拓也, Sam S. Berclay, 伊藤日加瑠, 黒巣佳祐, 塩飽裕樹, 島村徹平, 田川一彦, 勝田明寿香, 曽根雅紀, 井元清哉, 宮野悟, 岡澤均
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2012-09-19
    • Data Source
      KAKENHI-PROJECT-23500401

  • [Presentation] ハンチントン病の分子病態解明2012
    • Author(s)
      岡澤均
    • Organizer
      第53回日本神経学会学術大会2011年度楢林賞受賞者招待講演
    • Place of Presentation
      東京国際フォーラム　東京
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] 網羅的リン酸化タンパク解析による変性病態シグナル解明に向けて2012
    • Author(s)
      岡澤均
    • Organizer
      パソシグナリングバイオロジー　ワークショップ
    • Place of Presentation
      東京医科歯科大学　東京
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] ポリグルタミン病の分子標的治療を目指して2012
    • Author(s)
      岡澤均
    • Organizer
      大阪大学蛋白質研究所セミナー
    • Place of Presentation
      大阪大学蛋白質研究所(大阪)
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Presentation] ハンチントン病におけるDNAの損傷と修復2012
    • Author(s)
      岡澤均
    • Organizer
      日本放射線影響学会第55回大会
    • Place of Presentation
      東北大学川内北キャンパス　仙台
    • Year and Date
      2012-09-06
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] Pathomechanisms of Intellectual Disabilities linked to a new RNA splicing protein,PQBP1.2012
    • Author(s)
      Okazawa H
    • Organizer
      Tokyo Medical and Dental University International Summer Program 2012
    • Place of Presentation
      Tokyo Medical and Dental University,MD Tower,Akio Suzuki Memorial Hall
    • Year and Date
      2012-08-27
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Presentation] Pathomechanisms of Intellectual Disability (ID) linked to a new RNA splicing protein,PQBP1.2012
    • Author(s)
      Okazawa H
    • Organizer
      Cell Symposia Functional RNAs
    • Place of Presentation
      Hotel Melia,Sitges,Spain
    • Year and Date
      2012-12-02
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] ポリグルタミン病の分子標的治療を目指して2012
    • Author(s)
      岡澤均
    • Organizer
      大阪大学蛋白質研究所セミナー
    • Place of Presentation
      大阪大学蛋白質研究所(大阪)
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] Pathomechanisms of PQBP1 in neurons and neural stem cells causing learning defect and microcephaly.2012
    • Author(s)
      Okazawa H
    • Organizer
      The 2nd Japan-Korea Neural Tissue culture seminar
    • Place of Presentation
      Tokyo Medical and Dental University,MD Tower,Akio Suzuki Memorial Hall
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] ポリグルタミン病の分子標的治療を目指して2012
    • Author(s)
      岡澤均
    • Organizer
      大阪大学蛋白質研究所セミナー
    • Place of Presentation
      大阪大学蛋白質研究所(大阪)
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] PQBP1遺伝子発現量と症状の相関関係2012
    • Author(s)
      田村拓也, 中村蓉子, 塩飽裕樹, 岡澤均
    • Organizer
      第31回日本認知症学会学術集会
    • Place of Presentation
      つくば国際会議場(茨城県つくば市)
    • Data Source
      KAKENHI-PROJECT-23500401

  • [Presentation] Pathomechanisms of PQBP1 in neurons and neural stem cells causing learning defect and microcephaly.2012
    • Author(s)
      Okazawa, H.
    • Organizer
      The 2nd Japan-Korea Neural Tissue culture seminar
    • Place of Presentation
      Tokyo Medical and Dental University,MD Tower,Akio Suzuki Memorial Hall
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Presentation] Pathomechanisms of Intellectual Disability (ID) linked to a new RNA splicing protein,PQBP1.2012
    • Author(s)
      Okazawa H
    • Organizer
      Cell Symposia Functional RNAs
    • Place of Presentation
      Hotel Melia,Sitges,Spain
    • Year and Date
      2012-12-02
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Presentation] 脳の老化と変性におけるDNA損傷修復2012
    • Author(s)
      岡澤均
    • Organizer
      第34回日本生物学的精神医学会
    • Place of Presentation
      神戸国際会議場　神戸
    • Year and Date
      2012-09-28
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] 発現量依存的に寿命をコントロールする遺伝子, PQBP12012
    • Author(s)
      田村拓也, 曽根雅紀, 中村蓉子, 島村徹平, 井元清哉, 宮野悟, 岡澤均
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場・マリンメッセ福岡(福岡県福岡市)
    • Year and Date
      2012-12-15
    • Data Source
      KAKENHI-PROJECT-23500401

  • [Presentation] 変性と発達障害をつなぐ分子PQBP1の病態機能2012
    • Author(s)
      岡澤均
    • Organizer
      都医学研セミナー
    • Place of Presentation
      東京都医学総合研究所　講堂　東京
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] PQBP1, a new major causative gene for mental retardation and microcephaly, regulates gene expression through mRNA splicing2011
    • Author(s)
      Okazawa, H.
    • Organizer
      Elsevier Conference "RNA Binding Proteins in Neurological Disease"
    • Place of Presentation
      Sheraton National, Arlington, U.S.A.
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] Single strand annealing of DNA double strand breaks is involved in the SCA1 pathology2011
    • Author(s)
      Okazawa, H., Tamura, T.
    • Organizer
      Gordon Conference "CAG Triplet Repeat Disorders"
    • Place of Presentation
      Il Ciocco Hotel and Resort Lucca, Barga, Italy
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] Single strand annealing of DNA double strand breaks is involved in the SCA1 pathology2011
    • Author(s)
      Okazawa, H., Tamura, T.
    • Organizer
      Gordon Conference "CAG Triplet Repeat Disorders"
    • Place of Presentation
      Il Ciocco Hotel and Resort Lucca, Barga, Italy
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Presentation] ポリグルタミン病とDNA ダメージ2011
    • Author(s)
      田村拓也, 曽根雅紀, 伊藤日加瑠, 塩飽裕樹, 田川一彦, 岡澤均
    • Organizer
      第4回分子高次機能研究会
    • Place of Presentation
      かんぽの宿(熊本県阿蘇市)
    • Year and Date
      2011-08-28
    • Data Source
      KAKENHI-PROJECT-23500401

  • [Presentation] SCA1病態におけるDNA損傷修復機構の関与2011
    • Author(s)
      曽根雅紀, 田村拓也, 岡澤均
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋国際会議場（名古屋市）
    • Data Source
      KAKENHI-PROJECT-23500401

  • [Presentation] Brain size control by PQBP1 in neural stem cells2011
    • Author(s)
      Okazawa, H.
    • Organizer
      iPS細胞等の初期ステージ橋渡し研究振興に向けたJST-CIRMワークショップ
    • Place of Presentation
      神戸ポートピアホテル(神戸)
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] Brain size control by PQBP1 in neural stem cells2011
    • Author(s)
      Okazawa, H.
    • Organizer
      iPS細胞等の初期ステージ橋渡し研究振興に向けたJST-CIRMワークショップ
    • Place of Presentation
      神戸ポートピアホテル(神戸)
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] PQBP-1 を介したポリグルタミン病の認知障害の分子メカニズム2011
    • Author(s)
      田村拓也, 曽根雅紀, 岡澤均
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2011-05-20
    • Data Source
      KAKENHI-PROJECT-23500401

  • [Presentation] Molecular Mechanisms of PQBP1-Linked MR and Microcephaly2011
    • Author(s)
      Okazawa, H
    • Organizer
      15th International Workshop on Fragile X and Other Early-Onset Cognitive Disorders, Harnack-House
    • Place of Presentation
      Berlin, Germany
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] PQBP-1を介したポリグルタミン病の認知障害の分子メカニズム2011
    • Author(s)
      田村拓也, 曽根雅紀, 岡澤均
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋国際会議場（名古屋市）
    • Data Source
      KAKENHI-PROJECT-23500401

  • [Presentation] 脊髄小脳変性症I 型におけるDNA損傷修復の関与2011
    • Author(s)
      田村拓也, 曽根雅紀, Sam Berclay, 伊藤日加瑠, 塩飽裕樹, 田川一彦, 岡澤均
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2011-09-15
    • Data Source
      KAKENHI-PROJECT-23500401

  • [Presentation] PQBP1, a new major causative gene for mental retardation and microcephaly, regulates gene expression through mRNA splicing2011
    • Author(s)
      Okazawa, H.
    • Organizer
      Elsevier Conference "RNA Binding Proteins in Neurological Disease"
    • Place of Presentation
      Sheraton National, Arlington, U.S.A.
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] in vivoスクリーニングに適した新規HD, SCA1モデル動物の開発2011
    • Author(s)
      阿部大数, 曽根雅紀, 田村拓也, 白石理沙, 岡澤均
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋国際会議場（名古屋市）
    • Data Source
      KAKENHI-PROJECT-23500401

  • [Presentation] Neurodegeneration and DNA damage2011
    • Author(s)
      岡澤均
    • Organizer
      第88回日本生理学会大会・第116回日本解剖学会総会全国学術集会合同大会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] SCA1病態におけるDNA損傷修復異常2011
    • Author(s)
      田村拓也、岡澤均
    • Organizer
      平成22年度厚生労働省科学研究費補助金「運動失調症の病態解明と治療法開発に関する研究班」平成22年度研究班会議
    • Place of Presentation
      都市センターホテル(東京)
    • Year and Date
      2011-01-13
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Presentation] ポリグルタミン病とDNAダメージ2011
    • Author(s)
      田村拓也, 曽根雅紀, 伊藤日加瑠, 塩飽裕樹, 田川一彦, 岡澤均
    • Organizer
      第4回分子高次機能研究会
    • Place of Presentation
      かんぽの宿（阿蘇市）
    • Data Source
      KAKENHI-PROJECT-23500401

  • [Presentation] in vivo スクリーニングに適した新規HD, SCA1 モデル動物の開発2011
    • Author(s)
      阿部大数, 曽根雅紀, 田村拓也, 白石理沙, 岡澤均
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2011-05-19
    • Data Source
      KAKENHI-PROJECT-23500401

  • [Presentation] ポリグルタミン病の病態解明から治療開発へ2011
    • Author(s)
      岡澤均
    • Organizer
      京都大学CREST特別講演
    • Place of Presentation
      京都大学(京都)
    • Year and Date
      2011-07-13
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Presentation] Neurodegeneration and DNA damage2011
    • Author(s)
      岡澤均
    • Organizer
      第88回日本生理学会大会・第116回日本解剖学会総会全国学術集会合同大会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Presentation] DNA損傷修復からみた神経変性機序2011
    • Author(s)
      岡澤均
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Presentation] Molecular Mechanisms of PQBP1-Linked MR and Microcephaly2011
    • Author(s)
      Okazawa, H.
    • Organizer
      15th International Workshop on Fragile X and Other Early-Onset Cognitive Disorders
    • Place of Presentation
      Harnack-House, Berlin, Germany
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] ポリグルタミン病の病態解明から治療開発へ2011
    • Author(s)
      岡澤均
    • Organizer
      京都大学CREST特別講演
    • Place of Presentation
      京都大学(京都)
    • Year and Date
      2011-07-13
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] DNA損傷修復からみた神経変性機序2011
    • Author(s)
      岡澤均
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] Single strand annealing of DNA double strand breaks is involved in the SCA1 pathology2011
    • Author(s)
      Okazawa, H., Tamura, T.
    • Organizer
      Gordon Conference "CAG Triplet Repeat Disorders"
    • Place of Presentation
      Il Ciocco Hotel and Resort Lucca, Barga, Italy
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] 脊髄小脳変性症I型におけるDNA損傷修復の関与2011
    • Author(s)
      田村拓也, 曽根雅紀, Sam Barclay, 伊藤日加瑠, 塩飽裕樹, 田川一彦, 岡澤均
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜（横浜市）
    • Data Source
      KAKENHI-PROJECT-23500401

  • [Presentation] SCA1 病態におけるDNA 損傷修復機構の関与2011
    • Author(s)
      曽根雅紀, 田村拓也, 岡澤均
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2011-05-19
    • Data Source
      KAKENHI-PROJECT-23500401

  • [Presentation] Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity2011
    • Author(s)
      Shiwaku, H., Okazawa, H.
    • Organizer
      The 6^<th> International Symposium of Institute Network and the 10^<th> Surugadai International Symposium, Joint Usage/Research Program of Medical Research Institute International Symposium
    • Place of Presentation
      Tokyo Medical and Dental University
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Presentation] Brain size control by PQBP1 in neural stem cells2011
    • Author(s)
      Okazawa, H.
    • Organizer
      iPS細胞等の初期ステージ橋渡し研究振興に向けたJST-CIRMワークショップ
    • Place of Presentation
      神戸ポートピアホテル(神戸)
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Presentation] SCA1病態におけるDNA損傷修復異常2011
    • Author(s)
      田村拓也、岡澤均
    • Organizer
      平成22年度厚生労働省科学研究費補助金「運動失調症の病態解明と治療法開発に関する研究班」平成22年度研究班会議
    • Place of Presentation
      都市センターホテル(東京)
    • Year and Date
      2011-01-13
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] DNA損傷修復からみた神経変性機序2011
    • Author(s)
      岡澤均
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity2011
    • Author(s)
      Shiwaku, H., Okazawa, H.
    • Organizer
      The 6^<th> International Symposium of Institute Network and the 10^<th> Surugadai International Symposium, Joint Usage/Research Program of Medical Research Institute International Symposium
    • Place of Presentation
      Tokyo Medical and Dental University
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] Molecular Mechanisms of PQBP1-Linked MR and Microcephaly2011
    • Author(s)
      Okazawa, H.
    • Organizer
      15^<th> International Workshop on Fragile X and Other Early-Onset Cognitive Disorders
    • Place of Presentation
      Harnack-House, Berlin, Germany
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Presentation] Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity2011
    • Author(s)
      Shiwaku, H., Okazawa, H.
    • Organizer
      The 6^<th> International Symposium of Institute Network and the 10^<th> Surugadai International Symposium, Joint Usage/Research Program of Medical Research Institute International Symposium
    • Place of Presentation
      Tokyo Medical and Dental University
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] PQBP1, a new major causative gene for mental retardation and microcephaly, regulates gene expression through mRNA splicing2011
    • Author(s)
      Okazawa, H.
    • Organizer
      Elsevier Conference "RNA Binding Proteins in Neurological Disease"
    • Place of Presentation
      Sheraton National, Arlington, U.S.A.
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Presentation] Molecular Mechanisms of PQBP1-Linked MR and Microcephaly2011
    • Author(s)
      Okazawa, H.
    • Organizer
      15^<th> International Workshop on Fragile X and Other Early-Onset Cognitive Disorders
    • Place of Presentation
      Harnack-House, Berlin, Germany
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] SCA1病態におけるDNA損傷修復異常2011
    • Author(s)
      田村拓也、岡澤均
    • Organizer
      平成22年度厚生労働省科学研究費補助金「運動失調症の病態解明と治療法開発に関する研究班」平成22年度研究班会議
    • Place of Presentation
      都市センターホテル(東京)
    • Year and Date
      2011-01-13
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] Neurodegeneration and DNA damage2011
    • Author(s)
      岡澤均
    • Organizer
      第88回日本生理学会大会・第116回日本解剖学会総会全国学術集会合同大会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] PQBP1 a new major causative gene for mental retardation and microcephaly, regulates gene expression through mRNA splicing. Elsevier Conference2011
    • Author(s)
      Okazawa, H
    • Organizer
      RNA Binding Proteins in Neurological Disease, Sheraton National
    • Place of Presentation
      Arlington, U. S. A
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] ポリグルタミン病の病態解明から治療開発へ2011
    • Author(s)
      岡澤均
    • Organizer
      京都大学CREST特別講演
    • Place of Presentation
      京都大学(京都)
    • Year and Date
      2011-07-13
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] Molecular Mechanisms of PQBP1-linked Developmental Disorders2010
    • Author(s)
      Okazawa, H
    • Organizer
      Seminar Henry Hood Research Program
    • Place of Presentation
      Weis Center for Research, Geisinger Chnic(Danville, USA)
    • Year and Date
      2010-09-30
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] 脊髄小脳失調症1型原因遺伝子Ataxin-1のnon-cell autonomous毒性はMAXERを介する2010
    • Author(s)
      塩飽裕紀、田村拓也、曽根雅紀、渡瀬啓、岡澤均
    • Organizer
      包括型脳科学研究推進支援ネットワーク 夏のワークショップ
    • Place of Presentation
      ホテル札幌芸文館(北海道)
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] 神経変性における神経細胞死2010
    • Author(s)
      岡澤均
    • Organizer
      第19回日本Cell Death学会学術集会-細胞死研究の新たなステージ-
    • Place of Presentation
      愛知県産業労働センター(愛知)
    • Year and Date
      2010-07-31
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] 精神遅滞を伴う自閉症関連遺伝子の解析と治療法開発2010
    • Author(s)
      田村拓也、岡澤均
    • Organizer
      「発達障害の神経科学的基盤の解明と治療法開発に関する研究」平成22年度第1回班会議
    • Place of Presentation
      小平市(東京)
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Presentation] 神経変性概念のパラダイムシフトと治療戦略2010
    • Author(s)
      岡澤均
    • Organizer
      第5回四大学連合文化講演会
    • Place of Presentation
      一橋記念講堂(東京)
    • Year and Date
      2010-10-08
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Presentation] 変異 ataxin-1および huntingtin の non-cell autonomous 毒性2010
    • Author(s)
      岡澤均
    • Organizer
      平成21年度厚生労働省科学研究費補助金「運動失調症の病態解明と治療法開発に関する研究」平成21年度研究班会議
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-20023011

  • [Presentation] ポリグルタミン病における凝集毒性概念の変遷と治療2010
    • Author(s)
      岡澤均
    • Organizer
      第29回日本認知症学会学術集会
    • Place of Presentation
      ウインクあいち(愛知)
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] Dynamic change of synapse molecule in developmental disorde2010
    • Author(s)
      Okazawa, H
    • Organizer
      Kick off symposium of Scientific Research on Innovative Area"Foundation of Synapse and Neurocircuit Pathology
    • Place of Presentation
      Tokyo Medical and Dental University(Tokyo)
    • Year and Date
      2010-10-27
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] 神経変性概念のパラダイムシフトと治療戦略2010
    • Author(s)
      岡澤均
    • Organizer
      第5回四大学連合文化講演会
    • Place of Presentation
      一橋記念講堂(東京)
    • Year and Date
      2010-10-08
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] 細胞機能から見たポリグルタミン病の神経変性2010
    • Author(s)
      岡澤均
    • Organizer
      東京大学大学院医学研究科講義
    • Place of Presentation
      東京大学(東京)
    • Year and Date
      2010-05-11
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] Suppression of the novel ER protein MAXER by mutant ataxin-1 in Bergman glia contributes to non-cell autonomous toxicity.2010
    • Author(s)
      Shiwaku, H., Okazawa, H.
    • Organizer
      The First International Conference of Neural Cell Culture
    • Place of Presentation
      Seoul (South Korea)
    • Year and Date
      2010-06-25
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] 変異 ataxin-1および huntingtin の non-cell autonomous 毒性2010
    • Author(s)
      岡澤均
    • Organizer
      平成21年度厚生労働省科学研究費補助金「運動失調症の病態解明と治療法開発に関する研究」平成21年度研究班会議
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-20058010

  • [Presentation] ハンチントン病におけるDNA損傷修復障害2010
    • Author(s)
      伊藤目加瑠、岡澤均
    • Organizer
      平成22年度日本生化学会関東支部例会・第51回新潟生化学懇話会合同研究集会
    • Place of Presentation
      長岡技術科学大学(新潟)
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] ポリグルタミン病における凝集毒性概念の変遷と治療2010
    • Author(s)
      岡澤均
    • Organizer
      第29回日本認知症学会学術集会
    • Place of Presentation
      ウインクあいち(愛知)
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] 脊髄小脳失調症1型原因遺伝子Ataxin-1のnon-cell autonomous毒性はMAXERを介する2010
    • Author(s)
      塩飽裕紀、田村拓也、曽根雅紀、渡瀬啓、岡澤均
    • Organizer
      包括型脳科学研究推進支援ネットワーク 夏のワークショップ
    • Place of Presentation
      ホテル札幌芸文館(北海道)
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Presentation] Dynamic change of synapse molecule in developmental disorder.2010
    • Author(s)
      Okazawa, H.
    • Organizer
      Kick off symposium of Scientific Research on Innovative Area "Foundation of Synapse and Neurocircuit Pathology"
    • Place of Presentation
      Tokyo Medical and Dental University (Tokyo)
    • Year and Date
      2010-10-27
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Presentation] 細胞内小胞輸送と神経変性:ショウジョウバエモデルを用いた解析2010
    • Author(s)
      曽根雅紀、岡澤均
    • Organizer
      包括型脳科学研究推進支援ネットワーク 夏のワークショップ
    • Place of Presentation
      ホテル札幌芸文館(北海道)
    • Year and Date
      2010-07-30
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] dPQBP1とprojection neuronと学習障害2010
    • Author(s)
      田村拓也、岡澤均
    • Organizer
      第3回分子高次機能研究会
    • Place of Presentation
      冠着荘(長野)
    • Year and Date
      2010-11-23
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Presentation] PQBP1関連精神遅滞モデルショウジョウバエにおける学習障害2010
    • Author(s)
      田村拓也、堀内大輔、曽根雅紀、齋藤 実、宮下知之、岡澤均
    • Organizer
      包括型脳科学研究推進支援ネットワーク 夏のワークショップ
    • Place of Presentation
      ホテル札幌芸文館(北海道)
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] Ataxin-1/Huntingtinのグリア細胞由来毒性の解析2010
    • Author(s)
      田村拓也、曽根雅紀、山下真弓、Wanker Erich E、岡澤均
    • Organizer
      第51回日本神経学会総会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] Fluctuation and function of polyglutamine tract binding protein-12010
    • Author(s)
      水口峰之、土谷芳、岡澤均、河野敬一
    • Organizer
      「揺らぎと生体機能」第4回公開シンポジウム
    • Place of Presentation
      滋賀県立県民交流センター(滋賀)
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] Fluctuation and function of polyglutamine tract binding protein12010
    • Author(s)
      水口峰之、土谷芳、岡澤均、河野敬一
    • Organizer
      「揺らぎと生体機能」第4回公開シンポジウム
    • Place of Presentation
      滋賀県立県民交流センター(滋賀)
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Presentation] 神経変性疾患におけるDNA修復異常と脳老化2010
    • Author(s)
      岡澤均
    • Organizer
      第5回Bone Forum in Hanno
    • Place of Presentation
      埼玉
    • Year and Date
      2010-03-03
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] 変異ハンチンチン蛋白質によるDNA修復酵素Ku70の阻害2010
    • Author(s)
      榎戸靖、田村拓也、伊藤日加瑠、小室晃彦、塩飽裕紀、Wanker Erich E、岡澤均
    • Organizer
      Neuro 2010
    • Place of Presentation
      神戸コンベンションセンター(兵庫)
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] Molecular Mechanisms of PQBP1-linked Developmental Disorders2010
    • Author(s)
      Okazawa, H.
    • Organizer
      Seminar, Henry Hood Research Program
    • Place of Presentation
      Weis Center for Research, Geisinger Clinic (Danville, USA)
    • Year and Date
      2010-09-30
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] 神経変性における神経細胞死2010
    • Author(s)
      岡澤均
    • Organizer
      第19回日本Cell Death学会学術集会-細胞死研究の新たなステージ-
    • Place of Presentation
      愛知県産業労働センター(愛知)
    • Year and Date
      2010-07-31
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Presentation] Dynamic change of synapse molecule in developmental disorder.2010
    • Author(s)
      Okazawa, H.
    • Organizer
      Kick off symposium of Scientific Research on Innovative Area "Foundation of Synapse and Neurocircuit Pathology"
    • Place of Presentation
      Tokyo Medical and Dental University (Tokyo)
    • Year and Date
      2010-10-27
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] 細胞内小胞輸送と神経変性:ショウジョウバエモデルを用いた解析2010
    • Author(s)
      曽根雅紀、岡澤均
    • Organizer
      包括型脳科学研究推進支援ネットワーク 夏のワークショップ
    • Place of Presentation
      ホテル札幌芸文館(北海道)
    • Year and Date
      2010-07-30
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Presentation] 精神遅滞を伴う自閉症関連遺伝子の解析と治療法開発2010
    • Author(s)
      田村拓也、岡澤均
    • Organizer
      「発達障害の神経科学的基盤の解明と治療法開発に関する研究」平成22年度第1回班会議
    • Place of Presentation
      小平市(東京)
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] Molecular Mechanisms of PQBP1-linked Developmental Disorders2010
    • Author(s)
      Okazawa, H.
    • Organizer
      Seminar, Henry Hood Research Program
    • Place of Presentation
      Weis Center for Research, Geisinger Clinic (Danville, USA)
    • Year and Date
      2010-09-30
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Presentation] 変異ハンチンチン職白質によるDNA修復酵素Ku70の阻害2010
    • Author(s)
      榎戸靖、田村拓也、伊藤日加瑠、小室晃彦、塩飽裕紀、Wanker ErichE、岡澤均
    • Organizer
      Neuro 2010
    • Place of Presentation
      神戸コンベンションセンター(兵庫)
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] 神経変性疾患におけるDNA修復異常と脳老化2010
    • Author(s)
      岡澤均
    • Organizer
      第5回 Bone Forum in Hanno
    • Place of Presentation
      埼玉
    • Year and Date
      2010-03-03
    • Data Source
      KAKENHI-PROJECT-20058010

  • [Presentation] Mutant huntingtin impairs Ku70-mediated DNArepair.2010
    • Author(s)
      Ito, H., Enokido, Y., Tamura, T., Okazawa, H.
    • Organizer
      The First International Conference of Neural Cell Culture
    • Place of Presentation
      Seoul (South Korea)
    • Year and Date
      2010-06-25
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] Mutant huntingtin impairs Ku70-mediated DNArepair.2010
    • Author(s)
      Ito, H., Enokido, Y., Tamura, T., Okazawa, H.
    • Organizer
      The First International Conference of Neural Cell Culture
    • Place of Presentation
      Seoul (South Korea)
    • Year and Date
      2010-06-25
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Presentation] 変異ハンチンチン蛋白質によるDNA損傷修復酵素Ku70の機能阻害2010
    • Author(s)
      榎戸靖、田村拓也、伊藤日加瑠、小室晃彦、塩飽裕紀、岡澤均
    • Organizer
      包括型脳科学研究推進支援ネットワーク 夏のワークシヨップ
    • Place of Presentation
      ホテル札幌芸文館(北海道)
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] 精神遅滞を伴う自閉症関連遺伝子の解析と治療法開発2010
    • Author(s)
      田村拓也、岡澤均
    • Organizer
      「発達障害の神経科学的基盤の解明と治療法開発に関する研究」平成22年度第1回班会議
    • Place of Presentation
      小平市(東京)
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] Fluctuation and function of polyglutamine tract binding protein12010
    • Author(s)
      水口峰之、土谷芳、岡澤均、河野敬一
    • Organizer
      「揺らぎと生体機能」第4回公開シンポジウム
    • Place of Presentation
      滋賀県立県民交流センター(滋賀)
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] ハンチントン病とDNA修復障害2010
    • Author(s)
      岡澤均
    • Organizer
      日本人類遺伝学会第55回大会
    • Place of Presentation
      大宮ソニックシティ(埼玉)
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] ポリグルタミン病における凝集毒性概念の変遷と治療2010
    • Author(s)
      岡澤均
    • Organizer
      第29回日本認知症学会学術集会
    • Place of Presentation
      ウインクあいち(愛知)
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Presentation] 神経変性概念のパラダイムシフトと治療戦略2010
    • Author(s)
      岡澤均
    • Organizer
      第5回四大学連合文化講演会
    • Place of Presentation
      一橋記念講堂(東京)
    • Year and Date
      2010-10-08
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] 脊髄小脳失調症l型原因遺伝子Ataxin-lのnon-cell autonomous毒性はMAXERを介する2010
    • Author(s)
      塩飽裕紀、田村拓也、曽根雅紀、渡瀬啓、岡澤均
    • Organizer
      包括型脳科学研究推進支援ネットワーク 夏のワークショップ
    • Place of Presentation
      ホテル札幌芸文館(北海道)
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] HDAC阻害剤によるPQBP1精神遅滞モデルマウスの治療2010
    • Author(s)
      伊藤日加瑠、黒澤大、貫名信行、岡澤均
    • Organizer
      包括型脳科学研究推進支援ネットワーク 夏のワークショップ
    • Place of Presentation
      ホテル札幌芸文館(北海道)
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Presentation] ハンチントン病とDNA修復障害2010
    • Author(s)
      岡澤均
    • Organizer
      日本人類遺伝学会第55回大会
    • Place of Presentation
      大宮ソニックシティ(埼玉)
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Presentation] 変性疾患細胞死モデルとしての転写障害性神経細胞死TRIAD2010
    • Author(s)
      岡澤均
    • Organizer
      第36回東京女子医科大学・神経懇話会
    • Place of Presentation
      東京女子医科大学(東京)
    • Year and Date
      2010-06-29
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Presentation] PQBP1関連精神遅滞モデルショウジョウバエにおける学習障害2010
    • Author(s)
      田村拓也、堀内大輔、曽根雅紀、齋藤実、宮下知之、岡澤均
    • Organizer
      包括型脳科学研究推進支援ネットワーク 夏のワークショップ
    • Place of Presentation
      ホテル札幌芸文館(北海道)
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] 感覚二次ニューロン依存的な記憶に関わる新規分子、dPQBP12010
    • Author(s)
      田村拓也、堀内大輔、Yi-Chung Chen、曽根雅紀、宮下知之、齊藤実、吉村奈津恵、Ann-Shyn Chiang、岡澤均
    • Organizer
      Neuro 2010
    • Place of Presentation
      神戸コンベンションセンター(兵庫)
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] 感覚二次ニューロン依存的な記憶に関わる新規分子、dPQBP12010
    • Author(s)
      田村拓也、堀内大輔、Yi-Chung Chen、曽根雅紀、宮下知之、齊藤実、吉村奈津恵、Ann-Shyn Chiang、岡澤均
    • Organizer
      Neuro 2010
    • Place of Presentation
      神戸コンベンションセンター(兵庫)
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] Mutant huntingtin impairs Ku70-mediated DNArepair2010
    • Author(s)
      Ito, H., Enokido, Y, Tamura, T, Okazawa, H.
    • Organizer
      The First International Conference of Neural Cell Culture
    • Place of Presentation
      Seoul(South Korea)
    • Year and Date
      2010-06-25
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] 感覚二次ニューロン依存的な記憶に関わる新規分子、dPQBP12010
    • Author(s)
      田村拓也、堀内大輔、Yi-Chung Chen、曽根雅紀、宮下知之、齊藤実、吉村奈津恵、Ann-Shyn Chiang、岡澤均
    • Organizer
      Neuro 2010
    • Place of Presentation
      神戸コンベンションセンター(兵庫)
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Presentation] 変異ハンチンチン蛋白質によるDNA損傷修復酵素Ku70の機能阻害2010
    • Author(s)
      榎戸靖、田村拓也、伊藤日加瑠、小室晃彦、塩飽裕紀、岡澤均
    • Organizer
      包括型脳科学研究推進支援ネットワーク 夏のワークショップ
    • Place of Presentation
      ホテル札幌芸文館(北海道)
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Presentation] 変異ataxin-1およびhuntingtinのnon-cell autonomous毒性2010
    • Author(s)
      岡澤均
    • Organizer
      平成21年度厚生労働省科学研究費補助金「運動失調症の病態解明と治療法開発に関する研究」平成21年度研究班会議
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] 変性疾患細胞死モデルとしての転写障害性神経細胞死TRIAD2010
    • Author(s)
      岡澤均
    • Organizer
      第36回東京女子医科大学・神経懇話会
    • Place of Presentation
      東京女子医科大学(東京)
    • Year and Date
      2010-06-29
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] PQBP1関連精神遅滞モデルショウジョウバエにおける学習障害2010
    • Author(s)
      田村拓也、堀内大輔、曽根雅紀、齋藤実、宮下知之、岡澤均
    • Organizer
      包括型脳科学研究推進支援ネットワーク 夏のワークショップ
    • Place of Presentation
      ホテル札幌芸文館(北海道)
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Presentation] Suppression of the novel ER protein MAXER by mutant ataxin-1 in Bergman glia Contributes to non-cell autonomous toxicity2010
    • Author(s)
      Shiwaku, H., Okazawa, H.
    • Organizer
      The First International Conference of Neural Cell Culture
    • Place of Presentation
      Seoul(South Korea)
    • Year and Date
      2010-06-25
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] 変性疾患細胞死モデルとしての転写障害性神経細胞死TRIAD2010
    • Author(s)
      岡澤均
    • Organizer
      第36回東京女子医科大学・神経懇話会
    • Place of Presentation
      東京女子医科大学(東京)
    • Year and Date
      2010-06-29
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] 変異ハンチンチン蛋白質によるDNA損傷修復酵素Ku70の機能阻害2010
    • Author(s)
      榎戸靖、田村拓也、伊藤日加瑠、小室晃彦、塩飽裕紀、岡澤均
    • Organizer
      包括型脳科学研究推進支援ネットワーク 夏のワークショップ
    • Place of Presentation
      ホテル札幌芸文館(北海道)
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] 神経変性における神経細胞死2010
    • Author(s)
      岡澤璽
    • Organizer
      第19回日本Cell Death学会学術集会 -細胞死研究の新たなステージ-
    • Place of Presentation
      愛知県産業労働センター(愛知)
    • Year and Date
      2010-07-31
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] Suppression of the novel ER protein MAXER by mutant ataxin-1 in Bergman glia contributes to non-cell autonomous toxicity.2010
    • Author(s)
      Shiwaku, H., Okazawa, H.
    • Organizer
      The First International Conference of Neural Cell Culture
    • Place of Presentation
      Seoul (South Korea)
    • Year and Date
      2010-06-25
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Presentation] dPQBP1とprqlection neuronと学習障害2010
    • Author(s)
      田村拓也、岡澤均
    • Organizer
      第3回分子高次機能研究会
    • Place of Presentation
      冠着荘(長野)
    • Year and Date
      2010-11-23
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] 変異ハンチンチン蛋白質によるDNA修復酵素Ku70の阻害2010
    • Author(s)
      榎戸靖、田村拓也、伊藤日加瑠、小室晃彦、塩飽裕紀、Wanker Erich E、岡澤均
    • Organizer
      Neuro 2010
    • Place of Presentation
      神戸コンベンションセンター(兵庫)
    • Data Source
      KAKENHI-PLANNED-22110002

  • [Presentation] 神経変性疾患におけるDNA修復異常と脳老化2010
    • Author(s)
      岡澤均
    • Organizer
      第5回 Bone Forum in Hanno
    • Place of Presentation
      埼玉
    • Year and Date
      2010-03-03
    • Data Source
      KAKENHI-PROJECT-20023011

  • [Presentation] HDAC阻害剤によるPQBPl精神遅滞モデルマウスの治療2010
    • Author(s)
      伊藤日加瑠、黒澤大、貫名信行、岡澤均
    • Organizer
      包括型脳科学研究推進支援ネットワーク 夏のワークショップ
    • Place of Presentation
      ホテル札幌芸文館(北海道)
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] dPQBP1とprojection neuronと学習障害2010
    • Author(s)
      田村拓也、岡澤均
    • Organizer
      第3回分子高次機能研究会
    • Place of Presentation
      冠着荘(長野)
    • Year and Date
      2010-11-23
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] HDAC阻害剤によるPQBP1精神遅滞モデルマウスの治療2010
    • Author(s)
      伊藤日加瑠、黒澤大、貫名信行、岡澤均
    • Organizer
      包括型脳科学研究推進支援ネットワーク 夏のワークショップ
    • Place of Presentation
      ホテル札幌芸文館(北海道)
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] ハンチントン病とDNA修復障害2010
    • Author(s)
      岡澤均
    • Organizer
      日本人類遺伝学会第55回大会
    • Place of Presentation
      大宮ソニックシティ(埼玉)
    • Data Source
      KAKENHI-ORGANIZER-22110001

  • [Presentation] Null mutation of Drosphila yata/CG1973, which regulates trafficking of Amyloid precursor protein like, results in progressive eye vacuolization brain volume reduction and lifespan shortening2009
    • Author(s)
      曽根雅紀, 岡澤均, 鍋島陽一
    • Organizer
      The 32^<nd> Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-20023011

  • [Presentation] ポリグルタミン病態における核ストレスの解析と治療応用2009
    • Author(s)
      岡澤均
    • Organizer
      平成21年度特定領域研究「統合脳」冬の班会議
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] ハンチントン病におけるDNA損傷修復異常に起因する神経変性分子機構の解析2009
    • Author(s)
      伊藤日加瑠、榎戸靖、田村拓也、岡澤均
    • Organizer
      第42回精神神経系薬物治療研究報告会
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-04
    • Data Source
      KAKENHI-PROJECT-20023011

  • [Presentation] PQBP1, a causative gene for mental retardation with microcephaly, regulates neural stem cell proliferation thorugh RNA splicing of APC42009
    • Author(s)
      岡澤均
    • Organizer
      Roche-Nature Medicine Translational Neuroscience Symposium
    • Place of Presentation
      Lucern, Switzerland
    • Data Source
      KAKENHI-PROJECT-20058010

  • [Presentation] 網羅的解析から見た神経変性の選択性と共通性2009
    • Author(s)
      岡澤均
    • Organizer
      第50回日本神経学会総会・イブニングセミナー6
    • Place of Presentation
      仙台
    • Year and Date
      2009-05-20
    • Data Source
      KAKENHI-PROJECT-20058010

  • [Presentation] ポリグルタミン病態における核ストレスの解析と治療応用2009
    • Author(s)
      岡澤均
    • Organizer
      平成21年度特定領域研究「統合脳」冬の班会議
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-20023011

  • [Presentation] マウス脳におけるHMGB1発現とDNA二重鎖切断の加齢依存的変化2009
    • Author(s)
      榎戸靖、吉武綾薫、伊藤日加瑠、岡澤均
    • Organizer
      第50回日本神経学会総会
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-20058010

  • [Presentation] 網羅的解析から見た神経変性の選択性と共通性2009
    • Author(s)
      岡澤均
    • Organizer
      第50回日本神経学会総会・イブニングセミナー6
    • Place of Presentation
      仙台
    • Year and Date
      2009-05-20
    • Data Source
      KAKENHI-PROJECT-20023011

  • [Presentation] ハンチントン病におけるDNA損傷修復異常に起因する神経変性分子機構の解析2009
    • Author(s)
      伊藤日加瑠、榎戸靖、田村拓也、岡澤均
    • Organizer
      第42回精神神経系薬物治療研究報告会
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-04
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] 網羅的解析から見た神経変性の選択性と共通性2009
    • Author(s)
      岡澤均
    • Organizer
      第50回日本神経学会総会・イブニングセミナー6
    • Place of Presentation
      仙台
    • Year and Date
      2009-05-20
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] Loss of yata/CG1973, a novel gene regulating the trafficking of the Amyloid precursor protein orthologue, induces developmental defects, deterioration of neural tissues and lifespan shortening2009
    • Author(s)
      曽根雅紀, 岡澤均, 鍋島陽一
    • Organizer
      The 9th Japanese Drosophila Research Conference
    • Place of Presentation
      掛川
    • Data Source
      KAKENHI-PROJECT-20023011

  • [Presentation] Loss of yata/CG1973, a novel gene regulating the trafficking of the Amyloid precursor protein orthologue, induces developmental defects, deterioration of neural tissues and lifespan shortening.2009
    • Author(s)
      Sone M, Okazawa H, Nabeshima Y
    • Organizer
      The 9th Japanese Drosophila Research Conference
    • Place of Presentation
      掛川
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] Molecular genetic analysis of the Drosphilia yata gene : genetic interaction with the APP homologue and involvement in the trafficking regulation of APP-related proteins2009
    • Author(s)
      曽根雅紀, 鍋島陽一, 岡澤均
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-20058010

  • [Presentation] ハンチントン病におけるDNA損傷修復異常に起因する神経変性分子機構の解析2009
    • Author(s)
      伊藤日加瑠、榎戸靖、田村拓也、岡澤均
    • Organizer
      第42回精神神経系薬物治療研究報告会
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-04
    • Data Source
      KAKENHI-PROJECT-20058010

  • [Presentation] PQBP1異常による発達障害の分子機構2009
    • Author(s)
      伊藤日加瑠、岡澤均
    • Organizer
      厚生労働省精神・神経疾患研究委託費「神経学的基盤に基づく発達障害の診断・治療ガイドライン策定に関する総合的研究」平成21年度研究班会議
    • Place of Presentation
      東京
    • Year and Date
      2009-11-29
    • Data Source
      KAKENHI-PROJECT-20023011

  • [Presentation] Fluctuation and function of polyglutamine tract binding protein-1.2009
    • Author(s)
      Mizuguchi M, Takahashi M, Okazawa H, Kawano K.
    • Organizer
      新学術領域研究「揺らぎと生体機能」第3回公開シンポジウム
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] Fluctuation and function of polyglutamine tract binding protein-12009
    • Author(s)
      Mizuguchi M, Takahashi M, Okazawa H, Kawano K.
    • Organizer
      新学術領域研究「揺らぎと生体機能」第3回公開シンポジウム
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-20023011

  • [Presentation] Knock down of PQBP1 inpairs anxiety-related cognition in mouse2009
    • Author(s)
      Ito H, Yoshimura N, Kurosawa M, Ishii S, Nukina N, Okazawa H.
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-20023011

  • [Presentation] マウス脳におけるHMGB1発現とDNA二重鎖切断の加齢依存的変化2009
    • Author(s)
      榎戸靖、吉武綾薫、伊藤日加瑠、岡澤均
    • Organizer
      第50回日本神経学会総会
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-20023011

  • [Presentation] Knock down of PQBP1 inpairs anxiety-related cognition in mouse.2009
    • Author(s)
      Ito H, Yoshimura N, Kurosawa M, Ishii S, Nuking N, Okazawa H.
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] PQBP1, a causative gene for mental retardation with microcephaly, regulates neural stem cell proliferation thorugh RNA splicing of APC42009
    • Author(s)
      岡澤均
    • Organizer
      Roche-Nature Medicine Translational Neuroscience Symposium
    • Place of Presentation
      Lucern, Switzerland
    • Data Source
      KAKENHI-PROJECT-20023011

  • [Presentation] ショウジョウバエAPPホモログの細胞内輸送を制御する新規分子yataの同定と遺伝学的解析2009
    • Author(s)
      曽根雅紀、岡澤均、鍋島陽一
    • Organizer
      第28回日本認知症学会学術集会
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-20058010

  • [Presentation] Molecular mechanisms of PQBP1-linked developmental disorders2009
    • Author(s)
      岡澤均
    • Organizer
      The 32^<nd> Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-20023011

  • [Presentation] Loss of yata/CG1973, a novel gene regulating the trafficking of the Amyloid precursor protein orthologue, induces developmental defects, deterioration of neural tissues and lifespan shortening2009
    • Author(s)
      曽根雅紀, 岡澤均, 鍋島陽一
    • Organizer
      The 9th Japanese Drosophila Research Conference
    • Place of Presentation
      掛川
    • Data Source
      KAKENHI-PROJECT-20058010

  • [Presentation] Null mutation of Drosphila yata/CG1973, which regulates trafficking of Amyloid precursor protein like, results in progressive eye vacuolization brain volume reduction and lifespan shortening2009
    • Author(s)
      曽根雅紀, 岡澤均, 鍋島陽一
    • Organizer
      The 32^<nd> Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-20058010

  • [Presentation] 網羅的解析から見える神経変性の特異性と共通性2009
    • Author(s)
      岡澤均
    • Organizer
      東京都神経科学総合研究所・先端研究セミナー
    • Place of Presentation
      東京
    • Year and Date
      2009-07-23
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] 網羅的解析から見える神経変性の特異性と共通性2009
    • Author(s)
      岡澤均
    • Organizer
      東京都神経科学総合研究所・先端研究セミナー
    • Place of Presentation
      東京
    • Year and Date
      2009-07-23
    • Data Source
      KAKENHI-PROJECT-20023011

  • [Presentation] Knock down of PQBP1 inpairs anxiety-related cognition in mouse2009
    • Author(s)
      Ito H, Yoshimura N, Kurosawa M, Ishii S, Nukina N, Okazawa H.
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-20058010

  • [Presentation] Fluctuation and function of polyglutamine tract binding protein-12009
    • Author(s)
      Mizuguchi M, Takahashi M, Okazawa H, Kawano K.
    • Organizer
      新学術領域研究「揺らぎと生体機能」第3回公開シンポジウム
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-20058010

  • [Presentation] ポリグルタミン病関連タンパクPQBP1の認知記憶機能への関与2009
    • Author(s)
      伊藤日加瑠、岡澤均
    • Organizer
      平成21年度 特定領域研究「統合脳」夏のワークショップ
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-20058010

  • [Presentation] Glial cell lineage expression of mutant ataxin-1 and huntingtin induces developmental and late onset neuronal pathologies in Drosphila models2009
    • Author(s)
      Tamura T, Yamashita M, Sone M, Okazawa H.
    • Organizer
      The 32^<nd> Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-20058010

  • [Presentation] Molecular genetic analysis of the Drosphilia yata gene : genetic interaction with the APP homologue and involvement in the trafficking regulation of APP-related proteins2009
    • Author(s)
      曽根雅紀, 鍋島陽一, 岡澤均
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-20023011

  • [Presentation] Analysis of molecular mechanisms of neurodegeneration with Drosophila.2009
    • Author(s)
      岡澤均
    • Organizer
      The 9th Japanese Drosophila Research Conference
    • Place of Presentation
      掛川
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] 神経幹細胞に発現する新規微小管結合分子 Maxcell の同定と神経発生制御2009
    • Author(s)
      塩飽裕紀、田村拓也、曽根雅紀、岡澤均
    • Organizer
      第50回日本神経学会総会
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-20058010

  • [Presentation] Glial cell lineage expression of mutant ataxin-1 and huntingtin induces developmental and late onset neuronal pathologies in Drosphila models.2009
    • Author(s)
      Tamura T, Yamashita M, Sone M, Okazawa H.
    • Organizer
      The 32^<nd> Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] PQBP1, a causative gene for mental retardation with microcephaly, regulates neural stem cell proliferation thorugh RNA splicing of APC4.2009
    • Author(s)
      岡澤均
    • Organizer
      Roche-Nature Medicine Translational Neuroscience Symposium
    • Place of Presentation
      Lucern, Switzerland
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] Molecular mechanisms of PQBP1-linked developmental disorders.2009
    • Author(s)
      岡澤均
    • Organizer
      The 32^<nd> Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] 網羅的解析から見える神経変性の特異性と共通性2009
    • Author(s)
      岡澤均
    • Organizer
      東京都神経科学総合研究所・先端研究セミナー
    • Place of Presentation
      東京
    • Year and Date
      2009-07-23
    • Data Source
      KAKENHI-PROJECT-20058010

  • [Presentation] 神経幹細胞に発現する新規微小管結合分子Maxcellの同定と神経発生制御2009
    • Author(s)
      塩飽裕紀、田村拓也、曽根雅紀、岡澤均
    • Organizer
      第50回日本神経学会総会
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] Glial cell lineage expression of mutant ataxin-1 and huntingtin induces developmental and late onset neuronal pathologies in Drosphila models2009
    • Author(s)
      Tamura T, Yamashita M, Sone M, Okazawa H.
    • Organizer
      The 32^<nd> Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-20023011

  • [Presentation] ポリグルタミン病関連タンパクPQBP1の認知記憶機能への関与2009
    • Author(s)
      伊藤日加瑠、岡澤均
    • Organizer
      平成21年度 特定領域研究「統合脳」夏のワークショップ
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-20023011

  • [Presentation] Molecular genetic analysis of the Drosphilia yata gene. genetic interaction with the APP homologue and involvement in the trafficking regulati on of APP-related proteins.2009
    • Author(s)
      Sone N, Nabeshima Y, Okazawa H.
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] Analysis of molecular mechanisms of neurodegeneration with Drosophila2009
    • Author(s)
      岡澤均
    • Organizer
      The 9th Japanese Drosophila Research Conference
    • Place of Presentation
      掛川
    • Data Source
      KAKENHI-PROJECT-20023011

  • [Presentation] Null mutation of Drosphila yata/CG1973, which regulates trafficking of Amyloid precursor protein like, results in progressive eye vacuolization brain volume reduction and lifespan shortening.2009
    • Author(s)
      Sone M, Okazawa H, Nabeshima Y.
    • Organizer
      The 32^<nd> Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] PQBP1異常による発達障害の分子機構2009
    • Author(s)
      伊藤日加瑠、岡澤均
    • Organizer
      厚生労働省精神・神経疾患研究委託費「神経学的基盤に基づく発達障害の診断・治療ガイドライン策定に関する総合的研究」平成21年度研究班会議
    • Place of Presentation
      東京
    • Year and Date
      2009-11-29
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] ショウジョウバエAPPホモログの細胞内輸送を制御する新規分子yataの同定と遺伝学的解析2009
    • Author(s)
      曽根雅紀、岡澤均、鍋島陽一
    • Organizer
      第28回日本認知症学会学術集会
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-20023011

  • [Presentation] ポリグルタミン病関連タンパクPQBP1の認知記憶機能への関与2009
    • Author(s)
      伊藤日加瑠、岡澤均
    • Organizer
      平成21年度 特定領域研究「統合脳」夏のワークショップ
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] マウス脳におけるHMGB1発現とDNA二重鎖切断の加齢依存的変化2009
    • Author(s)
      榎戸靖、吉武綾薫、伊藤日加瑠、岡澤均
    • Organizer
      第50回日本神経学会総会
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] ショウジョウバエAPPホモログの細胞内輸送を制御する新規分子yataの同定と遺伝学的解析2009
    • Author(s)
      曽根雅紀、岡澤均、鍋島陽一
    • Organizer
      第28回日本認知症学会学術集会
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-21390265

  • [Presentation] Analysis of molecular mechanisms of neurodegeneration with Drosophila2009
    • Author(s)
      岡澤均
    • Organizer
      The 9th Japanese Drosophila Research Conference
    • Place of Presentation
      掛川
    • Data Source
      KAKENHI-PROJECT-20058010

  • [Presentation] PQBP1異常による発達障害の分子機構2009
    • Author(s)
      伊藤日加瑠、岡澤均