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Takahashi Ryosuke  高橋 良輔

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… Alternative Names

TAKAHASHI Ryosuke  高橋 良輔

高橋 良輔  タカハシ リョウスケ

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Researcher Number 90216771
Other IDs
External Links
Affiliation (Current) 2022: 京都大学, 医学研究科, 教授
Affiliation (based on the past Project Information) *help 2015 – 2022: 京都大学, 医学研究科, 教授
2017: 京都大学, 医学部, 教授
2017: 京都大学, 大学院医学研究科臨床神経学, 教授
2015: 京都大学, 大学院医学研究科, 教授
2011 – 2015: 京都大学, 医学(系)研究科(研究院), 教授 … More
2005 – 2012: 京都大学, 医学研究科, 教授
2007 – 2011: 京都大学, 大学院・医学研究科, 教授
2009: 京都大学, 医学部, 教授
2009: 京都大学, 物質-細胞統合システム拠点, 教授
2006: University of Kyoto, Department of Neurology, Professor
2006: Kyoto University, Graduate School of Medicine, Professor, 大学院医学研究科, 教授
2005 – 2006: 京都大学, 医学部, 教授
2005: 京都大学, 医学系研究所, 教授
2005: 京都大学, 大学院・医学研究科, 教授
2004: RIKEN, Lab Motor System Neurodegeneration, Laboratory Head, 運動神経変性研究チーム, チームリーダー
2003 – 2004: 独立行政法人理化学研究所, 運動系神経変性研究チーム, チームリーダー
2002: 理化学研究所, 運動系神経変性研究チーム, チームリーダー
1999 – 2001: 理化学研究所, 運動系神経変性研究チーム, チームリーダー(研究職)
2000: 東京都神経科学総合研究所, 主任研究員
2000: TOKYO METRO, INST.NEUROBIOL.PRINCIPAL INVESTIGATOR, 神経科学, 主任研究員
1993 – 1997: (財)東京都神経科学総合研究所, 神経学研究部門, 主任研究員
1995: 東京都神経科学総合研究所, 神経学研究部門, 主事研究員 Less
Review Section/Research Field
Principal Investigator
Biological Sciences / Neurology / Neurology / Medium-sized Section 52:General internal medicine and related fields
Except Principal Investigator
Neurology / Neurochemistry/Neuropharmacology / Cerebral neurosurgery / Nerve anatomy/Neuropathology / Neurology / Biological pharmacy / Nerve anatomy/Neuropathology / Risk sciences of radiation/Chemicals / Nerve anatomy/Neuropathology
Keywords
Principal Investigator
ALS / パーキンソン病 / トランスジェニックマウス / Parkin / 筋萎縮性側索硬化症 / ユビキチンリガーゼ / 小胞体ストレス / 脳神経疾患 / HtrA2 / 運動ニューロン … More / SOD1 / AR-JP / Pael-R / メダカ / Omi / XIAP / BIR / GluR2 / PINK1 / 神経科学 / 遺伝子 / α-シヌクレイン / IAP / Glup / αシヌクレイン / CNTF / 神経栄養因子 / 遺伝子変異 / スプライシング / アポトーシス阻害タンパク / カスペース-3 / カスペース-7 / 競合的阻害剤 / 非競合的阻害剤 / 遺伝子ノックアウト / コリンアセチル転移酵素 / グルタミン酸受容体 / AMPA受容体 / AMPA / アポトーシス / Hsp70 / CHIP / 酸化的ストレス / ミトコンドリア / Rpt3 / モデル動物 / GBA / カスパーゼ / caspase / ER stress / Hsp90 / cdc37 / 多系統萎縮症 / 毛様体神経栄養因子 / ciliary neurotrophic factor / ヒト / null mutation / 痴呆 / 変異遺伝子 / 危険因子 / 変異SODトランスジェニックマウス / カルシウム毒性 / glutamate / Calcium / Misfolding / p35 / カスパーゼ-9 / S5a / G93A / 酸化ストレス / E3 / ドーパミン毒性 / ノックアウトマウス / ドーパミン / BiP / CHOP / トランスジェニックマス / ドパミン / パーンソン病 / ATF6α / 遺伝子ノックアウトマウス / MEF / アデノウイルス / PARK 2 / ノルアドレナリン / NET / プロテアソーム / コンディショナルノックアウト / 神経変性疾患 / RP t 3 / 26Sプロテアソーム / コンディショナルノックアウトマウス / VAChT-Cre / アルツハイマー病 / タンパク分解 / Cre-lox system / TILING / ミトファジー / マイクロアレイ / 細胞死 / 改造学 / 蛋白質 / 解剖学 / Proteasome / Autophagy / Medaka / Gaucher disease / Lysosome / Alpha-synuclein / 内科 / トランスレーショナルリサーチ / proteasome / micorarray / TDP-43 / Cullin-2 / VHL / プロテアソーム分解系 / 神経外伝播 / HTS / 疾患モデルマウス / ゲノム / 発現制御 / α‐シヌクレイン / リングフィンガー / カスペース3 / カスペース7 / RINGフィンガー / Ubiquitin ligase / RING finger / mitochondria / Peal-R / ERストレス / 変異S0D1 / レビー小体 / パエル受容体 / AR-AP / ショウジョウバエ / ERAD / Parkinson disease / parkin / mutant SOD1 / transgenic mouse / AMPA receptor / Lewy小体 / PACRG / BAC / 行動解析 / ENU / PARK4 / PARK6 / Lewy body / PARCG / 脂質 / GBA1 / マウス / ゴーシェ病 / 脳・神経 / glucocerebrosidase / フィブリル伝播 / 遺伝子改変マウス / アルファシヌクレイン … More
Except Principal Investigator
神経変性疾患 / パーキンソン病 / 神経科学 / アセチルコリン / 筋萎縮性側索硬化症 / 脳神経疾患 / コリンアセチル転移酵素 / コリン作動性ニューロン / 小胞体ストレス / ERAD / ユビキチンリガーゼ / 神経細胞死 / アポトーシス / parkin / ALS / cDNA / アセチルコリントランスポーター / トランスジェニックマウス / 小胞体 / ケミカルシャペロン / アルツハイマー病 / 構造活性相関 / APP / ユビキチン / プロテアソーム / knockout mouse / GluR2 / ADAR2 / α-シヌクレイン / 神経伝達物質 / 神経終末 / 分子生物学 / 神経損傷 / シナプス小胞 / 神経病態生化学 / ワクチン / 抗体療法 / 免疫療法 / ミクログリア / 運動ニューロン死 / ハイブリドーマ / superoxide dismutase 1(SOD1) / グリア細胞 / 実験脳外科学 / ES細胞 / 神経分化 / 細胞移植 / 炎症 / 酸化ストレス / 不溶化 / Dorfin / Aβ / Parkin / HtrA2 / ノックアウトマウス / Parkinson' sdisease / Parkinson's disease / Parkinson' s disease / 神経内科学 / 幹細胞 / Omi/HtrA2 / ミトコンドリア / XIAP / α-synuclein / 293細胞 / 細胞死 / パーキン蛋白 / PARKIN / APOPTOSIS / PARKINSON'S DISEASE / NEURON DEATH / 293 CELL / 一酸化窒素(NO) / 蛋白質ジスルフィドイソメラーゼ(PDI) / ニトロシル化 / バーキン / Pael受容体(Pael-R) / パーキン / カスパーゼ / 内在性抵抗因子 / 小胞体関連タンパク質分解 / GMEB1 / ニューロン / グリア / ストレス / 脳虚血 / nitric oxide (NO) / ER stress / protein disulfide isomerase (PDI) / nitrosylation / neurodegenerative disease / Pael receptor (Pael-R) / transgenic mouse / グルタミン酸受容体 / AMPA受容体 / RNA編集 / 動物モデル / G1uR2 / 核酸 / Degenerative neurological disease / Amyotrophic Lateral Sclerosis / glutamate receptor / AMPA receptor / RNA editing / SOD1 / プロテオーム / 異常タンパク仮説 / Neurodegenerative disease / Neuroscience / SODl / 脳科学 / 研究支援 / 研究集会 / 研究リソース / 技術開発 / 若手研究者育成支援 / 研究リソース支援 / 技術開発支援 / ブレインバンク / 脳画像データベース / モデル動物 / 脳分子プロファイル / ウイルスベクター / オプチニューリン / NF-κB / ゴルジ装置断片化 / 炎症性サイトカイン / NF-кB / 有害化学物質 / 化審法 / 遺伝毒物学 / 発がん物質 / 変異原 / 小核実験 / ハイスループットスクリーニング / レギュラトリーサイエンス / 小核試験 / はいスループットスクリーニング / 情報学 / データマイニング / DT40細胞 / パーキンソン認知症複合 / 紀伊半島 / タウタンパク / TDP-43 / ポリユビキチン / ポリユビキチン鎖 / タンパク分解系 / 神経炎症 / 神経病理 / 遺伝子解析 / 記憶痕跡 / 2光子in vivoイメージング / 前初期遺伝子 / Arc / BACトランスジェニックマウス / 脳・神経 / in vivoイメージング / 2光子顕微鏡 / 薬剤スクリーニング / シヌクレイン / スクリーニング / 薬理学 / アストロサイト Less

  • Research Projects

    (50 results)

  • Research Products

    (553 results)

  • Co-Researchers

    (373 People)

  •  前駆期パーキンソン病をターゲットとした病態解明と疾患修飾療法の開発Principal Investigator

    • Principal Investigator
      高橋 良輔
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 52:General internal medicine and related fields
    • Research Institution
      Kyoto University

  •  Investigating the pathogenesis and development of therapeutics of alpha-synucleinopathyPrincipal Investigator

    • Principal Investigator
      Takahashi Ryosuke
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 52:General internal medicine and related fields
    • Research Institution
      Kyoto University

  •  αシヌクレイン伝播に基づく新規パーキンソン病モデルマウスの作製と病態解析Principal Investigator

    • Principal Investigator
      高橋 良輔
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University

  •  脳内環境：恒常性維持機構とその破綻Principal Investigator

    • Principal Investigator
      高橋 良輔
    • Project Period (FY)
      2016
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Research Institution
      Kyoto University

  •  Neuronal circuitry rewiring during the progression of Parkinson's disease

    • Principal Investigator
      Hatanaka Yusuke
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Neurology
    • Research Institution
      Kyoto University

  •  Drug screening for suppression of alpha-synulcein expression

    • Principal Investigator
      Uemura Maiko
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Neurology
    • Research Institution
      Kyoto University

  •  Unveiling the Pathological Mechanisms and Developing New Treatment of Parkinsons Disease Caused by GBA1 MutationsPrincipal Investigator

    • Principal Investigator
      Takahashi Ryosuke
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Neurology
    • Research Institution
      Kyoto University

  •  Creation of ALS treatment seed by latest comprehensive neuroscience research for Kii ALS/PDC

    • Principal Investigator
      Ito Hidefumi
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      Wakayama Medical University

  •  Analyzing the pathogenesis of neurodegenerative diseases using medaka with multigene mutations.Principal Investigator

    • Principal Investigator
      Takahashi Ryosuke
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Neurology
    • Research Institution
      Kyoto University

  •  Elucidating pathomechanism of ALS through the abnormality in astrocytes

    • Principal Investigator
      YAMANAKA Koji
    • Project Period (FY)
      2014 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      Nagoya University

  •  Investigation of pathomechanism and novel therapeutic strategy for ALS on the basis of optineurin dysfunction

    • Principal Investigator
      Ito Hidefumi
    • Project Period (FY)
      2012 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      Wakayama Medical University

  •  遺伝性パーキンソン病動物モデルに基づく選択的ドパミン神経変性のメカニズムの解明Principal Investigator

    • Principal Investigator
      高橋 良輔
    • Project Period (FY)
      2011
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University

  •  Brain EnvironmentPrincipal Investigator

    • Principal Investigator
      Takahashi Ryosuke
    • Project Period (FY)
      2011 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University

  •  Disturbance of brain environment by impairment of proteolysis leading to neurodegenerationPrincipal Investigator

    • Principal Investigator
      Takahashi Ryosuke
    • Project Period (FY)
      2011 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University

  •  Identification of small molecules that down-regulate alpha-synuclein transcriptionPrincipal Investigator

    • Principal Investigator
      TAKAHASHI RYOSUKE
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      Kyoto University

  •  Brain EnvironmentArea Organizer

    • Area Organizer
      高橋 良輔
    • Project Period (FY)
      2011 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  •  Establishment of high-throughput screening of toxic chemical compounds.

    • Principal Investigator
      Takeda Shunichi
    • Project Period (FY)
      2011 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Risk sciences of radiation/Chemicals
    • Research Institution
      Kyoto University

  •  Research on the role of Omi/HtrA2 in the abnormal mitochondria in patients with Parkinson's disease

    • Principal Investigator
      KAWAMOTO Yasuhiro
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Kyoto University

  •  Comprehensive Brain Science Network

    • Principal Investigator
      Kimura Minoru
    • Project Period (FY)
      2010 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Research Institution
      Center for Novel Science Initatives, National Institutes of Natural Sciences

  •  The inhibitory mechanism of unfolded protein accumulation in the endoplasmic reticulum : Studies on anti-neurodegeneration drug discovery

    • Principal Investigator
      NOMURA Yasuyuki
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Yokohama College of Pharmacy

  •  Biochemical and neuropathological analysis of HtrA2 knockout mouse

    • Principal Investigator
      ITO Hidefumi
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      Kyoto University

  •  Drug development for ALS using astrocytes derived from patient-specific iPSCs

    • Principal Investigator
      INOUE Haruhisa
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Kyoto University

  •  パエル受容体のドーパミンニューロンの機能維持と変性における役割の解明Principal Investigator

    • Principal Investigator
      高橋 良輔
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University

  •  The analysis of participation in the ubiquitin proteasome system for understanding the mechanisms of neurodegenerative diseases.Principal Investigator

    • Principal Investigator
      TAKAHASHI Ryosuke
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      Kyoto University

  •  Optimization of the host brain environment for the cell replacement therapy using ES cells

    • Principal Investigator
      TAKAHASHI Jun
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kyoto University

  •  The inhibitory mechanism of novel proteins induced in the endoplasmic reticulum and of drugs on neurodegenerative diseases

    • Principal Investigator
      NOMURA Yasuyuki
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Yokohama College of Pharmacy

  •  Development of an immunotherapy against ALS model mice and analysis of the role of microglia in the pathogenesis of ALS

    • Principal Investigator
      URUSHITANI Makoto
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      Shiga University of Medical Science

  •  パーキンソン病におけるパエル受容体の病態的役割の解明Principal Investigator

    • Principal Investigator
      高橋 良輔
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University

  •  Elucidation of the fumctional network among the genes for familial Parkinson diseasePrincipal Investigator

    • Principal Investigator
      TAKAHASHI Ryosuke
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      Kyoto University

  •  パーキンソン病におけるパエル受容体の病態生理的役割の解明Principal Investigator

    • Principal Investigator
      高橋 良輔
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University

  •  Production of sporadic ALS model mice by targeting the ADAR2 gene in motor neurons

    • Principal Investigator
      KWAK Shin
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      The University of Tokyo

  •  Motor neuron-selective cytotoxicity caused by ALS-linked mutant SOD1 proteins

    • Principal Investigator
      TATENO Minako
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      National Institute of Neuroscience, NCNP

  •  ALSマウスモデルの神経変性におけるプロテアソームの役割に関する研究Principal Investigator

    • Principal Investigator
      高橋 良輔
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The Institute of Physical and Chemical Research

  •  運動ニューロン特異的遺伝子過剰発現マウスを用いたALSの実験的治療の研究Principal Investigator

    • Principal Investigator
      高橋 良輔
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The Institute of Physical and Chemical Research

  •  Studies on the Regulatory Mechanism of Neuronal Death: Isolation of Novel Factors and Title of Preparation of Model of Neurodegenerative Disease.

    • Principal Investigator
      NOMURA Yasuyuki
    • Project Period (FY)
      2003 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Biological pharmacy
    • Research Institution
      Hokkaido University

  •  運動ニューロン特異的遺伝子過剰発現マウスを用いたALSの実験的治療の研究Principal Investigator

    • Principal Investigator
      高橋 良輔
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The Institute of Physical and Chemical Research

  •  The molecular mechanisms underlying neurodegenerationPrincipal Investigator

    • Principal Investigator
      TAKAHASHI Ryosuke
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Neurology
    • Research Institution
      The Institute of Physical and Chemical Research

  •  運動ニューロン特異的遺伝子発現・ノックアウトシステムの確立Principal Investigator

    • Principal Investigator
      高橋 良輔
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      The Institute of Physical and Chemical Research

  •  運動ニューロン特異的遺伝子発現・ノックアウトシステムの確立Principal Investigator

    • Principal Investigator
      高橋 良輔
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      The Institute of Physical and Chemical Research

  •  アポトーシス阻害タンパク(IAP)によるカスペース阻害の分子機構の解明Principal Investigator

    • Principal Investigator
      高橋 良輔
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      The Institute of Physical and Chemical Research

  •  FUNCTIONAL ANALYSIS OF PARKIN

    • Principal Investigator
      MATSUMINE Hiroto
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      JUNTENDO UNIVERSITY

  •  Molecular mechanism of action of X-linked inhibitor of apoptosis proteinPrincipal Investigator

    • Principal Investigator
      TAKAHASHI Ryosuke
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      RIKEN

  •  コリン作動性神経分化に伴う遺伝子発現機構の解明

    • Principal Investigator
      三澤 日出巳
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience

  •  コリン作動性神経分化に伴う遺伝子発現制御機構の解明

    • Principal Investigator
      三澤 日出巳
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience

  •  コリン作動性神経分化に伴う遺伝子発現制御機構の解明

    • Principal Investigator
      三澤 日出巳
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience

  •  ヒトの毛様体神経栄養因子に関する分子遺伝学的研究Principal Investigator

    • Principal Investigator
      高橋 良輔
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Neurology
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience

  •  ヒトにおける毛様体神経栄養因子(CNTF)の遺伝的欠損に関する分子遺伝学的研究Principal Investigator

    • Principal Investigator
      高橋 良輔
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience

  •  ヒトの運動ニューロン栄養因子に関する分子遺伝学的研究Principal Investigator

    • Principal Investigator
      高橋 良輔
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Neurology
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience

  •  神経終末におけるアセチルコリンの生合成及び放出の分子生物学的研究

    • Principal Investigator
      MISAWA Hidemi
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience

  •  運動ニューロン栄養因子に関する分子生物学的研究Principal Investigator

    • Principal Investigator
      高橋 良輔
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Neurology
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience

All 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 Other

All Journal Article Presentation Book

  • [Book] medicina2014
    • Author(s)
      山下博史、高橋良輔
    • Total Pages
      5
    • Publisher
      医学書院
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Book] 神経疾患 最新の治療2015－20172014
    • Author(s)
      陣上直人、高橋良輔
    • Total Pages
      301
    • Publisher
      南江堂
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Book] Nihon Naika Gakkai Zasshi.2013
    • Author(s)
      Kondo T, Inoue H, Takahashi R.
    • Total Pages
      300
    • Publisher
      New and future treatments for neurological disorders--knowledge essential to daily clinics and future prospects. Topics: 15. Therapeutic application of iPS cells.
    • Data Source
      KAKENHI-PLANNED-23111002

  • [Book] 脳神経科学イラストレイテッド 改訂第3版　「ALSなど運動ニューロン病」の章2013
    • Author(s)
      山下博史、高橋良輔
    • Total Pages
      395
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PLANNED-23111002

  • [Book] 孤発性パーキンソン病におけるiPS細胞研究2013
    • Author(s)
      小芝泰、高橋良輔
    • Total Pages
      4
    • Publisher
      医学のあゆみ
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Book] MOOK別冊「細胞死研究の今－疾患との関わり、創薬に向けてのアプローチ」2013
    • Author(s)
      守村 敏史，高橋 良輔，漆谷 真
    • Total Pages
      44
    • Publisher
      メディカルドゥ
    • Data Source
      KAKENHI-PLANNED-23111002

  • [Book] 臨床神経学2013
    • Author(s)
      Takahashi R.
    • Publisher
      Societas Neurologica Japonica
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Book] Medical Science Digest 39巻2013
    • Author(s)
      高橋 良輔
    • Total Pages
      100
    • Publisher
      ニューサイエンス社
    • Data Source
      KAKENHI-PLANNED-23111002

  • [Book] 変性疾患【１）鉄と神経変性疾患】2013
    • Author(s)
      浅野剛史、高橋良輔
    • Publisher
      神経 5巻
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Book] Medical Science Digest 39巻2013
    • Author(s)
      高橋良輔
    • Publisher
      ニューサイエンス社
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Book] Annual Review神経　20132013
    • Author(s)
      糸数 隆秀、高橋 良輔、山下 俊英
    • Total Pages
      278
    • Publisher
      中外医学社
    • Data Source
      KAKENHI-PLANNED-23111002

  • [Book] 日本内科学会雑誌2013
    • Author(s)
      Kondo T, Inoue H, Takahashi R.
    • Total Pages
      2015
    • Publisher
      日本内科学会
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Book] ミスフォールド蛋白質による神経細胞死と治療戦略.2013
    • Author(s)
      守村 敏史、高橋 良輔、漆谷 真
    • Total Pages
      44
    • Publisher
      メディカルドゥ
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Book] ミスフォールド蛋白質による神経細胞死と治療戦略.MOOK別冊「細胞死研究の今-疾患との関わり 創薬に向けてのアプローチ」2013
    • Author(s)
      守村敏史, 高橋良輔, 漆谷真
    • Total Pages
      44
    • Publisher
      メディカルドゥ
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Book] 脳21 16巻(1)2013
    • Author(s)
      澤田知世、今居 譲、高橋良輔
    • Publisher
      金芳堂
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Book] Annual Review神経　20132013
    • Author(s)
      糸数隆秀、高橋良輔、山下俊英
    • Total Pages
      278
    • Publisher
      中外医学社
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Book] 細胞死研究の今-疾患との関わり、創薬に,創薬に向けてのアプローチ-2013
    • Author(s)
      守村敏史，高橋良輔，漆谷 真
    • Total Pages
      8
    • Publisher
      メディカルドゥ
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Book] 脳21　16巻（１）2013
    • Author(s)
      澤田知世、今居 譲、高橋良輔
    • Total Pages
      6
    • Publisher
      金芳堂
    • Data Source
      KAKENHI-PLANNED-23111002

  • [Book] 臨床神経学2013
    • Author(s)
      Takahashi R.
    • Total Pages
      500
    • Publisher
      JSN treatment guideline for Parkinson's disease: its editorial policy and problems to be addressed.
    • Data Source
      KAKENHI-PLANNED-23111002

  • [Book] Stem Cells and Cancer Stem Cells2011
    • Author(s)
      Kondo T, Takahashi R, Inoue H.
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-21591079

  • [Book] パーキンソン病「ガイドライン外来診療2011」泉孝英編2011
    • Author(s)
      伊東秀文、高橋良輔
    • Publisher
      日経メディカル開発
    • Data Source
      KAKENHI-PROJECT-21500336

  • [Book] Stem Cells and Cancer Stem Cells2011
    • Author(s)
      Kondo I., Takahashi R., Inoue H.
    • Total Pages
      8
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-21591079

  • [Book] パーキンソン症候群(SND, PSP, CBD)「研修医のための神経内科診療」阿部康二編2010
    • Author(s)
      伊東秀文、高橋良輔
    • Publisher
      新興医学出版社
    • Data Source
      KAKENHI-PROJECT-21500336

  • [Book] Protein Misforlding and Axonal Protection in Neurodegenerative, Disease Protein Folding and Misfolding : Neurodegenerative Diseases2008
    • Author(s)
      Inoue H, Kondo T, Lin L, Mi S, Isacson O, Takahashi R
    • Publisher
      Ovadi, J.and Orosz. F.Springer, Hungary
    • Data Source
      KAKENHI-PROJECT-20390244

  • [Book] The molecular pathway to neurodegeneration in parkin-related parkinsonism. In Protein Degradation2007
    • Author(s)
      Takahashi, R.
    • Publisher
      Wiley-VCH, Weinheim
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390255

  • [Book] 細胞死・アポトーシス集中マスター2006
    • Author(s)
      高橋良輔
    • Total Pages
      130
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-17025048

  • [Book] わかる実験医学シリーズ ユビキチンがわかる タンパク質分解と多彩な生命機能を制御する修飾因子 田中啓二/編2004
    • Author(s)
      高橋良輔
    • Total Pages
      138
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-16015330

  • [Book] わかる実験医学シリーズユビキチンがわかるタンパク質分解と多彩な生命機能を制御する修飾因子(田中啓二/編)2004
    • Author(s)
      高橋良輔
    • Total Pages
      138
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-14207032

  • [Book] The molecular pathway to neurodegeneration in parkin-related parkinsonism. In Protein Degradation
    • Author(s)
      Takahashi, R.
    • Total Pages
      2007
    • Publisher
      Wiley-VCH, Weinheim
    • Data Source
      KAKENHI-PROJECT-18390255

  • [Book] Parkin and stress. In Molecular Mechanisms in Parkinson's disease,
    • Author(s)
      Imai, Y., Takahashi, R.
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14207032

  • [Book] 再生医療叢書第7巻
    • Author(s)
      近藤孝之, 井上治久, 高橋良輔
    • Publisher
      朝倉書店(印刷中)
    • Data Source
      KAKENHI-PROJECT-21591079

  • [Book] 再生医療叢書第7巻
    • Author(s)
      近藤孝之, 井上治久, 高橋良輔
    • Publisher
      朝倉書店
    • Data Source
      KAKENHI-PROJECT-21591079

  • [Journal Article] Long-term safety and efficacy of adjunctive rasagiline in levodopa-treated Japanese patients with Parkinson’s disease2019
    • Author(s)
      Hattori Nobutaka、Takeda Atsushi、Takeda Shinichi、Nishimura Akira、Nakaya Ryou、Mochizuki Hideki、Nagai Masahiro、Takahashi Ryosuke
    • Journal Title

      Journal of Neural Transmission

      Volume: 126 Pages: 289-297

    • DOI

      10.1007/s00702-018-1962-5

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-17H05698

  • [Journal Article] GBA haploinsufficiency accelerates alpha synuclein pathology with altered lipid metabolism in a prodromal model of Parkinson's disease2019
    • Author(s)
      Ikuno Masashi、Yamakado Hodaka、Akiyama Hisako、Parajuli Laxmi Kumar、Taguchi Katsutoshi、Hara Junko、Uemura Norihito、Hatanaka Yusuke、Higaki Katsumi、Ohno Kousaku、Tanaka Masaki、Koike Masato、Hirabayashi Yoshio、Takahashi Ryosuke
    • Journal Title

      Human Molecular Genetics

      Volume: 印刷中 Pages: 1894-1904

    • DOI

      10.1093/hmg/ddz030

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08522, KAKENHI-PROJECT-17K15608, KAKENHI-PROJECT-17KK0147, KAKENHI-PUBLICLY-17H05698, KAKENHI-PROJECT-18K14842, KAKENHI-PROJECT-17H03553

  • [Journal Article] Visually-Rated Medial Temporal Lobe Atrophy with Lower Educational History as a Quick Indicator of Amnestic Cognitive Impairment after Stroke2019
    • Author(s)
      Takahashi Yukako、Saito Satoshi、Yamamoto Yumi、Uehara Toshiyuki、Yokota Chiaki、Sakai Go、Nishida Norifumi、Takahashi Ryosuke、Kalaria Raj N.、Toyoda Kazunori、Nagatsuka Kazuyuki、Ihara Masafumi
    • Journal Title

      Journal of Alzheimer's Disease

      Volume: 67 Pages: 621-629

    • DOI

      10.3233/jad-180976

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-17H05698

  • [Journal Article] Phosphorylated NF-κB subunit p65 aggregates in granulovacuolar degeneration and neurites in neurodegenerative diseases with tauopathy2019
    • Author(s)
      Yamaguchi Yuko、Ayaki Takashi、Li Fangzhou、Tsujimura Atsushi、Kamada Masaki、Ito Hidefumi、Maki Takakuni、Sawamoto Nobukatsu、Urushitani Makoto、Takahashi Ryosuke
    • Journal Title

      Neuroscience Letters

      Volume: 704 Pages: 229-235

    • DOI

      10.1016/j.neulet.2019.03.036

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-17H05698, KAKENHI-PROJECT-16K18383, KAKENHI-PROJECT-19K16277

  • [Journal Article] TDP-43 levels are higher in platelets from patients with sporadic amyotrophic lateral sclerosis than in healthy controls2019
    • Author(s)
      Hishizawa Miki、Yamashita Hirofumi、Akizuki Mayumi、Urushitani Makoto、Takahashi Ryosuke
    • Journal Title

      Neurochemistry International

      Volume: 124 Pages: 41-45

    • DOI

      10.1016/j.neuint.2018.12.009

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-17H05698

  • [Journal Article] Role of Perivascular Oligodendrocyte Precursor Cells in Angiogenesis After Brain Ischemia2019
    • Author(s)
      Kishida Natsue、Maki Takakuni、Takagi Yasushi、Yasuda Ken、Kinoshita Hisanori、Ayaki Takashi、Noro Takayuki、Kinoshita Yusuke、Ono Yuichi、Kataoka Hiroharu、Yoshida Kazumichi、Lo Eng H.、Arai Ken、Miyamoto Susumu、Takahashi Ryosuke
    • Journal Title

      Journal of the American Heart Association

      Volume: 8

    • DOI

      10.1161/jaha.118.011824

    • NAID

      120006980544

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-17H05698, KAKENHI-PROJECT-19K16277

  • [Journal Article] Long-term, open-label, phase 3 study of rasagiline in Japanese patients with early Parkinson’s disease2019
    • Author(s)
      Hattori Nobutaka、Takeda Atsushi、Takeda Shinichi、Nishimura Akira、Kitagawa Tadayuki、Mochizuki Hideki、Nagai Masahiro、Takahashi Ryosuke
    • Journal Title

      Journal of Neural Transmission

      Volume: 126 Pages: 299-308

    • DOI

      10.1007/s00702-018-1964-3

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-17H05698

  • [Journal Article] Efficacy and safety of adjunctive rasagiline in Japanese Parkinson's disease patients with wearing-off phenomena: A phase 2/3, randomized, double-blind, placebo-controlled, multicenter study2018
    • Author(s)
      Hattori Nobutaka、Takeda Atsushi、Takeda Shinichi、Nishimura Akira、Kato Masafumi、Mochizuki Hideki、Nagai Masahiro、Takahashi Ryosuke
    • Journal Title

      Parkinsonism & Related Disorders

      Volume: 53 Pages: 21-27

    • DOI

      10.1016/j.parkreldis.2018.04.025

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-17H05698

  • [Journal Article] Japanese multicenter database of healthy controls for [123I]FP-CIT SPECT2018
    • Author(s)
      Matsuda H, Murata M, Mukai Y, Sako K, Ono H, Toyama H, Inui Y, Taki Y, Shimomura H, Nagayama H, Tateno A, Ono K, Murakami H, Kono A, Hirano S, Kuwabara S, Maikusa N, Ogawa M, Imabayashi E, Sato N, Takano H, Hatazawa J, Takahashi R
    • Journal Title

      European Journal of Nuclear Medicine and Molecular Imaging

      Volume: 45 Pages: 1405-1416

    • DOI

      10.1007/s00259-018-3976-5

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09793, KAKENHI-PUBLICLY-17H05698

  • [Journal Article] Pathological endogenous α-synuclein accumulation in oligodendrocyte precursor cells potentially induces inclusions in multiple system atrophy.2018
    • Author(s)
      Kaji Seiji、Maki Takakuni、Kinoshita Hisanori、Uemura Norihito、Ayaki Takashi、Kawamoto Yasuhiro、Furuta Takahiro、Urushitani Makoto、Hasegawa Masato、Kinoshita Yusuke、Ono Yuichi、Mao Xiaobo、Quach Tran H.、Iwai Kazuhiro、Dawson Valina L.、Dawson Ted M.、Takahashi Ryosuke
    • Journal Title

      Stem Cell Reports

      Volume: 10 Pages: 30530-1

    • DOI

      10.1016/j.stemcr.2017.12.001

    • NAID

      120006377705

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26290023, KAKENHI-PUBLICLY-17H05698, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-17H06174, KAKENHI-PROJECT-15H02356, KAKENHI-PROJECT-15H04266, KAKENHI-PROJECT-16K18383

  • [Journal Article] Ser46-Phosphorylated MARCKS Is a Marker of Neurite Degeneration at the Pre-aggregation Stage in PD/DLB Pathology2018
    • Author(s)
      Fujita Kyota、Homma Hidenori、Kondo Kanoh、Ikuno Masashi、Yamakado Hodaka、Tagawa Kazuhiko、Murayama Shigeo、Takahashi Ryosuke、Okazawa Hitoshi
    • Journal Title

      eneuro

      Volume: 5 Pages: 0217-18

    • DOI

      10.1523/eneuro.0217-18.2018

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-17H05698, KAKENHI-PROJECT-16K07040, KAKENHI-PROJECT-16H02655

  • [Journal Article] Amyotrophic Lateral Sclerosis after Receiving the Human Papilloma Virus Vaccine: A Case Report of a 15-year-old Girl2018
    • Author(s)
      Hikiami Ryota、Yamakado Hodaka、Tatsumi Shinsui、Ayaki Takashi、Hashi Yuichiro、Yamashita Hirofumi、Sawamoto Nobukatsu、Tsuji Teruyuki、Urushitani Makoto、Takahashi Ryosuke
    • Journal Title

      Internal Medicine

      Volume: * Issue: 13 Pages: 1917-1919

    • DOI

      10.2169/internalmedicine.0285-17

    • NAID

      130007387154

    • ISSN
      0918-2918, 1349-7235
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26290023, KAKENHI-PUBLICLY-17H05698, KAKENHI-PROJECT-16K18383, KAKENHI-PROJECT-16K09672

  • [Journal Article] Homozygous 31 trinucleotide repeats in the SCA2 allele are pathogenic for cerebellar ataxia2018
    • Author(s)
      Tojima Maya、Murakami Gaku、Hikawa Rie、Yamakado Hodaka、Yamashita Hirofumi、Takahashi Ryosuke、Matsui Masaru
    • Journal Title

      Neurology Genetics

      Volume: 4

    • DOI

      10.1212/nxg.0000000000000283

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-17H05698

  • [Journal Article] NLRP3 Inflammasome-Related Proteins Are Upregulated in the Putamen of Patients With Multiple System Atrophy2018
    • Author(s)
      Li Fangzhou、Ayaki Takashi、Maki Takakuni、Sawamoto Nobukatsu、Takahashi Ryosuke
    • Journal Title

      Journal of Neuropathology & Experimental Neurology

      Volume: 77 Pages: 1055-1065

    • DOI

      10.1093/jnen/nly090

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-17H05698, KAKENHI-PROJECT-16K18383

  • [Journal Article] Multiple Proteinopathies in Familial ALS Cases With Optineurin Mutations2018
    • Author(s)
      Ayaki T, Ito H, Komure O, Kamada M, Nakamura M, Wate R, Kusaka H, Yamaguchi Y, Li F, Kawakami H, Urushitani M, Takahashi R
    • Journal Title

      Journal of Neuropathology & Experimental Neurology

      Volume: 77 Pages: 128-138

    • DOI

      10.1093/jnen/nlx109

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26290023, KAKENHI-PROJECT-15H04270, KAKENHI-PROJECT-16K15481, KAKENHI-PROJECT-16K18383

  • [Journal Article] Inoculation of α-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve.2018
    • Author(s)
      Uemura Norihito、Yagi Hisashi、Uemura Maiko T.、Hatanaka Yusuke、Yamakado Hodaka、Takahashi Ryosuke
    • Journal Title

      Molecular Neurodegeneration

      Volume: 13 Pages: 21-21

    • DOI

      10.1186/s13024-018-0257-5

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-17H05698, KAKENHI-PROJECT-17K16119

  • [Journal Article] Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes.2018
    • Author(s)
      Komine Okiru、Yamashita Hirofumi、Fujimori-Tonou Noriko、Koike Masato、Jin Shijie、Moriwaki Yasuhiro、Endo Fumito、Watanabe Seiji、Uematsu Satoshi、Akira Shizuo、Uchiyama Yasuo、Takahashi Ryosuke、Misawa Hidemi、Yamanaka Koji
    • Journal Title

      Cell Death Differ

      Volume: 印刷中 Pages: 2130-2146

    • DOI

      10.1038/s41418-018-0098-3

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08522, KAKENHI-PROJECT-26293208, KAKENHI-PUBLICLY-16H01336, KAKENHI-PUBLICLY-17H05698, KAKENHI-PROJECT-17H04257, KAKENHI-PROJECT-18H02571, KAKENHI-PROJECT-18H02740, KAKENHI-PROJECT-17H04986, KAKENHI-PROJECT-17K19543, KAKENHI-PROJECT-17K14963

  • [Journal Article] FKBP12-immunopositive inclusions in patients with α-synucleinopathies2018
    • Author(s)
      Honjo Yasuyuki、Ayaki Takashi、Horibe Tomohisa、Ito Hidefumi、Takahashi Ryosuke、Kawakami Koji
    • Journal Title

      Brain Research

      Volume: 1680 Pages: 39-45

    • DOI

      10.1016/j.brainres.2017.12.012

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15H04270

  • [Journal Article] Human iPS cell-derived dopaminergic neurons function in a primate Parkinson's disease model.2017
    • Author(s)
      Kikuchi Tetsuhiro、Morizane Asuka、Doi Daisuke、Magotani Hiroaki、Onoe Hirotaka、Hayashi Takuya、Mizuma Hiroshi、Takara Sayuki、Takahashi Ryosuke、Inoue Haruhisa、Morita Satoshi、Yamamoto Michio、Okita Keisuke、Nakagawa Masato、Parmar Malin、Takahashi Jun
    • Journal Title

      Nature

      Volume: 548 Pages: 592-596

    • DOI

      10.1038/nature23664

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-17H05698, KAKENHI-PROJECT-15H02502, KAKENHI-PROJECT-15H02540, KAKENHI-PROJECT-16H03300, KAKENHI-PROJECT-16H03306, KAKENHI-PROJECT-15K12779

  • [Journal Article] Decreased levels of PDI and P5 in oligodendrocytes in Alzheimer's disease2017
    • Author(s)
      Honjo Yasuyuki、Ayaki Takashi、Tomiyama Takami、Horibe Tomohisa、Ito Hidefumi、Mori Hiroshi、Takahashi Ryosuke、Kawakami Koji
    • Journal Title

      Neuropathology

      Volume: 37 Pages: 495-501

    • DOI

      10.1111/neup.12395

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K18383, KAKENHI-PROJECT-15H04270

  • [Journal Article] Three-year follow-up of high-dose ubiquinol supplementation in a case of familial multiple system atrophy with compound heterozygous COQ2 mutations2017
    • Author(s)
      Mitsui J, Koguchi K, Momose T, Takahashi M, Matsukawa T, Yasuda T, Tokushige S, Ishiura H, Goto J, Nakazaki S, Kondo T, Ito H, Yamamoto Y and Tsuji S.
    • Journal Title

      The Cerebellum

      Volume: - Pages: 664-672

    • DOI

      10.1007/s12311-017-0846-9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26253054, KAKENHI-PROJECT-26350915, KAKENHI-PROJECT-17H06159, KAKENHI-PROJECT-15H04270, KAKENHI-PROJECT-15K09334

  • [Journal Article] αシヌクレインの凝集・伝播と細胞死2017
    • Author(s)
      澤村正典、上村紀仁、高橋良輔
    • Journal Title

      医学のあゆみ

      Volume: 262 Pages: 585-589

    • Data Source
      KAKENHI-PROJECT-15H02540

  • [Journal Article] Idiopathic Parkinson's disease patient-derived induced pluripotent stem cells function as midbrain dopaminergic neurons in rodent brains2017
    • Author(s)
      Kikuchi T, Morizane A, Doi D, Okita K, Nakagawa M, Yamakado H, Inoue H, Takahashi R, Takahashi J.
    • Journal Title

      Journal of Neuroscience Research

      Volume: ー Pages: 1829-1837

    • DOI

      10.1002/jnr.24014

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H02540, KAKENHI-PROJECT-16K09672

  • [Journal Article] αシヌクレインの凝集・伝播と細胞死2017
    • Author(s)
      澤村正典、上村紀仁、高橋良輔
    • Journal Title

      医学のあゆみ

      Volume: 262 Pages: 585-589

    • Data Source
      KAKENHI-PUBLICLY-17H05698

  • [Journal Article] The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis2017
    • Author(s)
      Imamura K, Izumi Y, 他24名, Hosokawa M, Akiyama H, Ayaki T, Ito H, Takahashi R, Yamanaka S, Inoue H
    • Journal Title

      Sci. Transl. Med.

      Volume: 9 Pages: 391-391

    • DOI

      10.1126/scitranslmed.aaf3962

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09850, KAKENHI-PROJECT-16K09681, KAKENHI-PROJECT-17K08593, KAKENHI-PROJECT-17KT0108, KAKENHI-PUBLICLY-17H05670, KAKENHI-PROJECT-15H04270, KAKENHI-PROJECT-15H05019, KAKENHI-PROJECT-17H06622, KAKENHI-PROJECT-15K06921, KAKENHI-PLANNED-26114009

  • [Journal Article] Pericyte-derived bone morphogenetic protein 4 underlies white matter damage after chronic hypoperfusion2017
    • Author(s)
      Uemura Maiko T.、Ihara Masafumi、Maki Takakuni、Nakagomi Takayuki、Kaji Seiji、Uemura Kengo、Matsuyama Tomohiro、Kalaria Raj N.、Kinoshita Ayae、Takahashi Ryosuke
    • Journal Title

      Brain pathology

      Volume: 31 May Pages: 1-15

    • DOI

      10.1111/bpa.12523

    • NAID

      120006305874

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-17H05698, KAKENHI-PROJECT-15K09329, KAKENHI-PROJECT-16K19509

  • [Journal Article] Zonisamide inhibits monoamine oxidase and enhances motor performance and social activity2017
    • Author(s)
      Uemura Maiko T.、Asano Takeshi、Hikawa Rie、Yamakado Hodaka、Takahashi Ryosuke
    • Journal Title

      Neuroscience research

      Volume: 124 Pages: 25-32

    • DOI

      10.1016/j.neures.2017.05.008

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-17H05698, KAKENHI-PROJECT-15H02540, KAKENHI-PROJECT-16K19509, KAKENHI-PROJECT-16K09672

  • [Journal Article] Network hyperexcitability in a patient with partial reading epilepsy: Converging evidence from magnetoencephalography, diffusion tractography, and functional magnetic2016
    • Author(s)
      Imamura, H., R. Matsumoto, S. Takaya, T. Nakagawa, A. Shimotake, T. Kikuchi, N. Sawamoto, T. Kunieda, N. Mikuni, S. Miyamoto, H. Fukuyama, R. Takahashi and A. Ikeda
    • Journal Title

      Epilepsy Res 2016

      Volume: 120 Pages: 65-72

    • DOI

      10.1016/j.eplepsyres.2015.12.003

    • NAID

      120005749848

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K10361, KAKENHI-PROJECT-26461309, KAKENHI-INTERNATIONAL-15K21731, KAKENHI-PROJECT-26560465, KAKENHI-PROJECT-25861273, KAKENHI-PROJECT-26282218, KAKENHI-PROJECT-26293209, KAKENHI-PLANNED-23111002, KAKENHI-PUBLICLY-15H01664, KAKENHI-ORGANIZER-15H05871, KAKENHI-PLANNED-15H05874, KAKENHI-PROJECT-15K09351, KAKENHI-PROJECT-16K09715

  • [Journal Article] Synergistic association of elevated serum free fatty acid and glucose levels with large arterial stiffness in a general population: The Nagahama Study.2016
    • Author(s)
      Yasuharu Tabara, Yoshimitsu Takahashi, Kazuya Setoh, Takahisa Kawaguchi, Norimoto Gotoh, Chikashi Terao, Ryo Yamada, Shinji Kosugi, Akihiro Sekine, Takeo Nakayama, Fumihiko Matsuda, on behalf of the Nagahama Study group.
    • Journal Title

      Metabolism.

      Volume: 65 Pages: 66-72

    • DOI

      10.1016/j.metabol.2015.10.011

    • NAID

      120005698009

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K08646, KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-25253059, KAKENHI-PROJECT-25462637, KAKENHI-PROJECT-25293141, KAKENHI-PROJECT-16H05496

  • [Journal Article] A novel reporter rat strain that conditionally expresses the bright red fluorescent protein tdTomato.2016
    • Author(s)
      Hiroyuki Igarashi; Kyo Koizumi; Ryosuke Kaneko; Keiko Ikeda; Ryo Egawa; Yuchio Yanagawa; Shin-ichi Muramatsu; Hiroshi Onimaru; Toru Ishizuka; Hiromu Yawo.
    • Journal Title

      PLoS ONE

      Volume: 印刷中

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-221S0003

  • [Journal Article] Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis2016
    • Author(s)
      Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H, Ishitani R, Kamei K, Takeyoshi I, Kawakami H, Iwai K, Hatada I, Sawasaki T, Ito H, Nureki O, and Tokunaga F.
    • Journal Title

      Nat Commun

      Volume: 7 Pages: 12547-12547

    • DOI

      10.1038/ncomms12547

    • NAID

      120006323739

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-15H01172, KAKENHI-PUBLICLY-16H01192, KAKENHI-PLANNED-16H06575, KAKENHI-PLANNED-16H06579, KAKENHI-PLANNED-24112002, KAKENHI-PROJECT-15H04270, KAKENHI-PROJECT-15H04694, KAKENHI-PROJECT-16H04729, KAKENHI-PROJECT-25291011, KAKENHI-PROJECT-15K18468, KAKENHI-PROJECT-15K08259, KAKENHI-PROJECT-16K15210, KAKENHI-PROJECT-16K18383

  • [Journal Article] Induced pluripotent stem cells in Parkinson's disease: scientific and clinical challenges.2016
    • Author(s)
      Xiao B, Ng HH, Takahashi R, Tan EK.
    • Journal Title

      J Neurol Neurosurg

      Volume: 0 Pages: 0-0

    • DOI

      10.1136/jnnp-2015-312036

    • NAID

      120005997794

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-23111002

  • [Journal Article] Benign adult familial myoclonus epilepsy is a progressive disorder: no longer idiopathic generalized epilepsy2016
    • Author(s)
      Hitomi T, Kobayashi K, Sakurai T, Ueda S, Jingami N, Kanazawa K, Matsumoto R, Takahashi R, Ikeda A.
    • Journal Title

      Epileptic Disord

      Volume: 18(1) Pages: 67-72

    • DOI

      10.1684/epd.2016.0807

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-15H05874, KAKENHI-PROJECT-25515001, KAKENHI-PROJECT-26560465, KAKENHI-PROJECT-26282218, KAKENHI-PROJECT-26293209, KAKENHI-PLANNED-23111002, KAKENHI-PUBLICLY-15H01664, KAKENHI-ORGANIZER-15H05871, KAKENHI-PROJECT-15K09351, KAKENHI-INTERNATIONAL-15K21731

  • [Journal Article] CUL2-mediated clearance of misfolded TDP-43 is paradoxically affected by VHL in oligodendrocytes in ALS2016
    • Author(s)
      Uchida T, Tamaki Y, Ayaki T, Shodai A, Kaji S, Morimura T, Banno Y, Nishitsuji K, Sakashita N, Maki T, Yamashita H, Ito H, Takahashi R, Urushitani M.
    • Journal Title

      Sci Rep

      Volume: 6 Pages: 19118-19118

    • DOI

      10.1038/srep19118

    • NAID

      120005689210

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26450403, KAKENHI-ORGANIZER-23111001, KAKENHI-PROJECT-15H04270, KAKENHI-PROJECT-26670190, KAKENHI-PROJECT-24300132, KAKENHI-PROJECT-26290023, KAKENHI-PLANNED-23111002, KAKENHI-PROJECT-15K19488, KAKENHI-PROJECT-16K08712

  • [Journal Article] Orbitofrontal sulcogyral pattern and olfactory sulcus depth in the schizophrenia spectrum.2016
    • Author(s)
      Nishikawa Y, Takahashi T, Takayanagi Y, Furuichi A, Kido M, Nakamura M, Sasabayashi D, Noguchi K, Suzuki M.
    • Journal Title

      European Archives of Psychiatry and Clinical Neurosciences

      Volume: 266 Pages: 15-23

    • DOI

      10.1007/s00406-015-0587-z

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26461739, KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-24390281

  • [Journal Article] Deletion of Atf6α enhances kainate-induced neuronal death in mice.2016
    • Author(s)
      Kezuka D, Tkarada-Iemata M, Hattori T, Mori K, Takahashi R, Kitao Y, Hori O
    • Journal Title

      Neurochem Int.

      Volume: 92 Pages: 67-74

    • DOI

      10.1016/j.neuint.2015.12.009

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26430069, KAKENHI-PROJECT-15K18374, KAKENHI-PUBLICLY-15H01374, KAKENHI-PLANNED-23111002

  • [Journal Article] Innate immunity regulates α-synuclein clearance2016
    • Author(s)
      Sawamura M, Uemura N, Takahashi R
    • Journal Title

      Movement Disorders

      Volume: 0 Pages: 0-0

    • DOI

      10.1002/mds.26571

    • Open Access
    • Data Source
      KAKENHI-PROJECT-15H02540, KAKENHI-PROJECT-26670442

  • [Journal Article] Activated caspase-9 immunoreactivity in glial and neuronal cytoplasmic inclusions in multiple system atrophy2016
    • Author(s)
      Kawamoto Y, Ayaki T, Urushitani M, Ito H, Takahashi R.
    • Journal Title

      Neurosci Lett

      Volume: 628 Pages: 207-212

    • DOI

      10.1016/j.neulet.2016.06.036

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H04270, KAKENHI-PROJECT-26290023, KAKENHI-PROJECT-16K18383

  • [Journal Article] Parkinson's disease patients showed delayed awareness of motor intention2015
    • Author(s)
      Tabu H, Aso T, Matsuhashi M, Ueki Y, Takahashi R, Fukuyama H, Shibasaki H, Mima T
    • Journal Title

      Neuroscience Research

      Volume: in press Pages: 0-0

    • DOI

      10.1016/j.neures.2015.01.012

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390292, KAKENHI-PROJECT-25461817, KAKENHI-PROJECT-15K09351, KAKENHI-PROJECT-15K09355, KAKENHI-PROJECT-22220003, KAKENHI-PLANNED-23111002, KAKENHI-PROJECT-15H01690

  • [Journal Article] The Parkinson’s disease-associated protein kinase LRRK2 modulates Notch signaling through the endosomal pathway.2015
    • Author(s)
      Imai Y, Kobayashi Y, Inoshita T, Meng H, Arano T, Uemura K, Asano T, Yoshimi K, Zhang CL, Matsumoto G, Ohtsuka T, Kageyama R, Kiyonari H, Shioi G, Nukina N, Hattori N, Takahashi R
    • Journal Title

      PLoS Genet

      Volume: 11

    • DOI

      10.1371/journal.pgen.1005503

    • NAID

      120005946994

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K06773, KAKENHI-PROJECT-26860219, KAKENHI-PUBLICLY-15H01561, KAKENHI-PLANNED-23111003, KAKENHI-PROJECT-15H02540, KAKENHI-PROJECT-15H04842, KAKENHI-PROJECT-26670442, KAKENHI-PLANNED-23111002

  • [Journal Article] Nanoscale distribution of presynaptic Ca(2+) channels and its impact on vesicular release during development.2015
    • Author(s)
      Nakamura Y, Harada H, Kamasawa N, Matsui K, Rothman JS, Shigemoto R, Silver RA, DiGregorio DA, Takahashi T
    • Journal Title

      Neuron

      Volume: 85 Pages: 145-158

    • DOI

      10.1016/j.neuron.2014.11.019

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-25115729, KAKENHI-PROJECT-25702054, KAKENHI-PUBLICLY-26117501, KAKENHI-PROJECT-221S0003

  • [Journal Article] Risk factors for infective complications with long term subdural electrode implantation in patients with medically intractable partial epilepsy2015
    • Author(s)
      Shibata, S., T. Kunieda, R. Inano, M. Sawada, Y. Yamao, T. Kikuchi, R. Matsumoto, A. Ikeda, R. Takahashi, N. Mikuni, J. Takahashi and S. Miyamoto
    • Journal Title

      World Neurosurg.

      Volume: - Pages: 320-326

    • DOI

      10.1016/j.wneu.2015.03.048

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24592159, KAKENHI-PROJECT-26282218, KAKENHI-PROJECT-26560465, KAKENHI-PLANNED-15H05874, KAKENHI-PROJECT-26293209, KAKENHI-PLANNED-23111002, KAKENHI-ORGANIZER-15H05871

  • [Journal Article] Transgenic supplementation of SIRT1 fails to alleviate acute loss of nigrostriatal dopamine neurons and gliosis in a mouse model of MPTP-induced parkinsonism.2015
    • Author(s)
      Kitao Y, Ageta-Ishihara N, Takahashi R, Kinoshita M, Hori O.
    • Journal Title

      F1000Research

      Volume: 4 Pages: 130-130

    • DOI

      10.12688/f1000research.6386.1

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26430069, KAKENHI-PROJECT-26440095, KAKENHI-PLANNED-23111002

  • [Journal Article] Assessment of Copy Number Variations in the Brain Genome of Schizophrenia Patients2015
    • Author(s)
      Sakai M, Watanabe Y, Someya T, Araki K, Shibuya M, Niizato K, Oshima K, Kunii Y, Yabe H, Matsumoto J, Wada A, Hino M, Hashimoto T, Hishimoto A, Kitamura N, Iritani S, Shirakawa O, Maeda K, Miyashita A, Niwa S, Takahashi H, Kakita A, Kuwano R, Nawa H
    • Journal Title

      Molecular Cytogenetics

      Volume: 印刷中

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-221S0003

  • [Journal Article] Use of a new generation of adaptive servo ventilation for sleep-disordered breathing in patients with multiple system atrophy.2015
    • Author(s)
      Hamada S, Takahashi R, Mishima M, Chin K.
    • Journal Title

      BMJ Case Rep.

      Volume: 6 Pages: 2015-2015

    • DOI

      10.1136/bcr-2014-206372

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-23111002

  • [Journal Article] Chemical corrector treatment ameliorates increased seizure susceptibility in a mouse model of familial epilepsy.2015
    • Author(s)
      Yokoi N, Fukata Y, Kase D, Miyazaki T, Jaegle M, Ohkawa T, Takahashi N, Iwanari H, Mochizuki Y, Hamakubo T, Imoto K, Meijer D, Watanabe M, Fukata M
    • Journal Title

      Nat Med,

      Volume: 21 Pages: 19-26

    • DOI

      10.1038/nm.3759

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-221S0003, KAKENHI-PLANNED-24108007, KAKENHI-PUBLICLY-25110733, KAKENHI-PROJECT-25220205, KAKENHI-PROJECT-25890021, KAKENHI-PROJECT-26291045, KAKENHI-PROJECT-26460250, KAKENHI-PROJECT-24220007

  • [Journal Article] Direct exploration of the role of the ventral anterior temporal lobe in semantic memory: Cortical stimulation and local field potential evidence from subdural grid electrodes2015
    • Author(s)
      Shimotake A, Matsumoto R, Ueno T, Kunieda T, Saito S, Hoffman P, Kikuchi T, Fukuyama H, Miyamoto S, Takahashi R, Ikeda A, Lambon Ralph MA
    • Journal Title

      Cereb Cortex

      Volume: 印刷中 Pages: 3802-17

    • DOI

      10.1093/cercor/bhu262

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26282218, KAKENHI-PROJECT-26560465, KAKENHI-PUBLICLY-15H01664, KAKENHI-PLANNED-15H05874, KAKENHI-PROJECT-22220003, KAKENHI-PROJECT-25861273, KAKENHI-PROJECT-26293209, KAKENHI-PLANNED-23111002, KAKENHI-ORGANIZER-15H05871

  • [Journal Article] Gradual cerebral hypoperfusion in spontaneously hypertensive rats induces slowly evolving white matter abnormalities and impairs working memory.2015
    • Author(s)
      Kitamura A, Saito S, Maki T, Oishi N, Ayaki T, Hattori Y, Yamamoto Y, Urushitani M, Kalaria RN, Fukuyama H, Horsburgh K, Takahashi R, Ihara M.
    • Journal Title

      J Cereb Blood Flow Metab.

      Volume: 0 Pages: 0-0

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-23111002

  • [Journal Article] Multiple neurological abnormalities, including pontine hemorrhage, multiple sclerosis and aseptic meningitis, during anti-TNF-α therapy in psoriatic arthritis.2015
    • Author(s)
      Honda Y, Otsuka A, Egawa G, Inoue Y, Kuzuya A, Takahashi R, Miyachi Y, Kabashima K.
    • Journal Title

      Eur J Dermatol.

      Volume: 25(5) Pages: 487-488

    • DOI

      10.1684/ejd.2015.2558

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-23111002

  • [Journal Article] Viable Neuronopathic Gaucher Disease Model in Medaka (Oryzias latipes) Displays Axonal Accumulation of Alpha-Synuclein.2015
    • Author(s)
      Norihito Uemura, Masato Koike, Satoshi Ansai, Masato Kinoshita, Tomoko Ishikawa-Fujiwara, Hideaki Matsui, Kiyoshi Naruse, Naoaki Sakamoto, Yasuo Uchiyama, Takeshi Todo, Shunichi Takeda, Hodaka Yamakado, Ryosuke Takahashi
    • Journal Title

      Pros Genetics

      Volume: 11 Pages: 1-14

    • DOI

      10.1371/journal.pgen.1005065

    • NAID

      120005593596

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-13J01682, KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-23241023, KAKENHI-PROJECT-25460276, KAKENHI-PUBLICLY-26111519, KAKENHI-PROJECT-26670442, KAKENHI-PROJECT-15K19486, KAKENHI-ORGANIZER-23111001, KAKENHI-PLANNED-23111004, KAKENHI-PROJECT-15H02540, KAKENHI-PROJECT-26860666, KAKENHI-PLANNED-23111002, KAKENHI-PROJECT-25281019, KAKENHI-PROJECT-15H05713

  • [Journal Article] Task-specific brain reorganization in motor recovery induced by a hybrid-rehabilitation combining training with brain stimulation after stroke2015
    • Author(s)
      Koganemaru S, Sawamoto N, Aso T, Sagara A, Ikkaku T, Shimada K, Kanematsu M, Takahashi R, Domen K, Fukuyama H, Mima T.
    • Journal Title

      Neuroscience Research

      Volume: 92 Pages: 29-38

    • DOI

      10.1016/j.neures.2014.10.004

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-13J05251, KAKENHI-PROJECT-24300192, KAKENHI-PROJECT-24390292, KAKENHI-PROJECT-26461309, KAKENHI-PROJECT-22220003, KAKENHI-PLANNED-23111002, KAKENHI-PROJECT-15H01690

  • [Journal Article] Different Mode of Afferents Determines the Frequency Range of High Frequency Activities in the Human Brain: Direct Electrocorticographic Comparison between Peripheral Nerve and Direct Cortical Stimulation.2015
    • Author(s)
      Kobayashi K, Matsumoto R, Matsuhashi M, Usami K, Shimotake A, Kunieda T, Kikuchi T, Mikuni N, Miyamoto S, Fukuyama H, Takahashi R, Ikeda A
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      PLoS One.

      Volume: 10 (6)

    • DOI

      10.1371/journal.pone.0130461

    • NAID

      120005674657

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PUBLICLY-15H01664, KAKENHI-PLANNED-15H05874, KAKENHI-PROJECT-22220003, KAKENHI-PROJECT-26560465, KAKENHI-PROJECT-25861273, KAKENHI-PROJECT-26282218, KAKENHI-PROJECT-26293209, KAKENHI-PLANNED-23111002, KAKENHI-ORGANIZER-15H05871, KAKENHI-PROJECT-15H01690

  • [Journal Article] パーキンソン病治療ガイドラインの現状と今後の展望2015
    • Author(s)
      高橋良輔
    • Journal Title

      Frontiers in Parkinson Diease

      Volume: 8 Pages: 5-11

    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Journal Article] Increased GADD34 in oligodendrocytes in Alzheimer's disease2015
    • Author(s)
      Honjo Y, Ayaki T, Tomiyama T, Horibe T, Ito H, Mori H, Takahashi R, Kawakami K.
    • Journal Title

      Neurosci. Lett

      Volume: 602 Pages: 50-55

    • DOI

      10.1016/j.neulet.2015.06.052

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15H04270, KAKENHI-PROJECT-24300132, KAKENHI-PROJECT-25290018, KAKENHI-PLANNED-23111002

  • [Journal Article] Anterograde c1ql1 signaling is required in order to determine and maintain a single-winner climbing fiber in the mouse cerebellum.2015
    • Author(s)
      Kakegawa W, Mitakidis N, Miura E, Abe M, Matsuda K, Takeo YH, Kohda K, Motohashi J, Takahashi A, Nagao S, Muramatsu SI, Watanabe M, Sakimura K, Aricescu AR, Yuzaki M
    • Journal Title

      Neuron.

      Volume: 85 Pages: 316-29

    • DOI

      10.1016/j.neuron.2014.12.020

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-14J07589, KAKENHI-PROJECT-221S0003, KAKENHI-PLANNED-23110009, KAKENHI-PROJECT-23240053, KAKENHI-PUBLICLY-25110729, KAKENHI-PROJECT-25460501, KAKENHI-PUBLICLY-26117515, KAKENHI-PROJECT-26293042, KAKENHI-PROJECT-26293213, KAKENHI-PROJECT-26430023, KAKENHI-PROJECT-26830017, KAKENHI-PROJECT-24220007, KAKENHI-PROJECT-24240048, KAKENHI-PROJECT-26640007

  • [Journal Article] Deletion of Atf6α impairs astroglial activation and enhances neuronal death following brain ischemia in mice2015
    • Author(s)
      Yoshikawa A, KamideT, Hashida K, Ta HM, Inahata Y, Takarada-Iemata M, Hattori T, Mori K, Takahashi R, Matsuyama T, Hayashi Y, Kitao Y, Hori O
    • Journal Title

      J Neurochem.

      Volume: 132(3) Pages: 342-353

    • DOI

      10.1111/jnc.12981

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24500419, KAKENHI-PROJECT-26430069, KAKENHI-PROJECT-15K06753, KAKENHI-PLANNED-23111002

  • [Journal Article] The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain neurodevelopmental markers in schizophrenia and healthy subjects2015
    • Author(s)
      Takahashi T, Nakamura M, Nakamura Y, Aleksic B, Kido M, Sasabayashi D, Takayanagi Y, Furuichi A, Nishikawa Y, Noguchi K, Ozaki N, Suzuki M
    • Journal Title

      Progress in Neuro-Psychopharmacology & Biological Psychiatry

      Volume: 56 Pages: 11-17

    • DOI

      10.1016/j.pnpbp.2014.07.005

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25670516, KAKENHI-PROJECT-26461739, KAKENHI-PROJECT-221S0003, KAKENHI-PLANNED-25117010, KAKENHI-PROJECT-25253072, KAKENHI-PROJECT-24390281

  • [Journal Article] SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70 chaperone system.2015
    • Author(s)
      Watanabe S, Ageta-Ishihara N, Nagatsu S, Takao K, Komine O, Endo F, Miyakawa T, Misawa H, Takahashi R, Kinoshita M, Yamanaka K.
    • Journal Title

      Mol Brain.

      Volume: 7 Pages: 2532-2532

    • DOI

      10.1186/s13041-014-0062-1

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-221S0003, KAKENHI-PLANNED-23111006, KAKENHI-PUBLICLY-25116514, KAKENHI-PUBLICLY-25116526, KAKENHI-PROJECT-25293020, KAKENHI-PROJECT-25350989, KAKENHI-PROJECT-25860252, KAKENHI-PUBLICLY-26115529, KAKENHI-PROJECT-26293208, KAKENHI-PROJECT-26440095, KAKENHI-PLANNED-23111002, KAKENHI-PROJECT-25242078

  • [Journal Article] iPS細胞を用いた神経変性疾患モデル2015
    • Author(s)
      後藤和也、高橋良輔、井上治久
    • Journal Title

      実験医学

      Volume: 33 Pages: 282-285

    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Journal Article] SIRT1 attenuates severe ischemic damage by preserving cerebral blood flow.2015
    • Author(s)
      Hattori Y, Okamoto Y, Nagatsuka K, Takahashi R, Kalaria RN, Kinoshita M, Ihara M
    • Journal Title

      Neuroreport.

      Volume: 26 Pages: 113-117

    • DOI

      10.1097/wnr.0000000000000308

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25640031, KAKENHI-PROJECT-26640034, KAKENHI-PLANNED-23111002

  • [Journal Article] Possible induction of multiple seizure foci due to parietal tumour and anti-NMDAR antibody.2015
    • Author(s)
      Matsumoto R, Mikuni N, Tanaka K, Usami K, Fukao K, Kunieda T, Takahashi Y, Miyamoto S, Fukuyama H, Takahashi R, Ikeda A
    • Journal Title

      Epileptic Disorder

      Volume: 17 (1) Pages: 89094-89094

    • DOI

      10.1684/epd.2015.0725

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26282218, KAKENHI-PROJECT-26560465, KAKENHI-PROJECT-15K09351, KAKENHI-PUBLICLY-15H01664, KAKENHI-PLANNED-15H05874, KAKENHI-PROJECT-22220003, KAKENHI-PROJECT-26293209, KAKENHI-PLANNED-23111002, KAKENHI-ORGANIZER-15H05871, KAKENHI-PROJECT-15H01690

  • [Journal Article] Sleep modulates cortical connectivity and excitability in humans: Direct evidence from neural activity induced by single-pulse electrical stimulation2015
    • Author(s)
      Usami K, Matsumoto R, Kobayashi K, Hitomi T, Shimotake A, Kikuchi T, Matsuhashi M, Kunieda T, Mikuni N, Miyamoto S, Fukuyama H, Takahashi R, Ikeda A.
    • Journal Title

      Hum Brain Mapp.

      Volume: 36(11) Pages: 0-0

    • DOI

      10.1002/hbm.22948

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09351, KAKENHI-PROJECT-15K10361, KAKENHI-PUBLICLY-15H01664, KAKENHI-PROJECT-22220003, KAKENHI-PROJECT-25515001, KAKENHI-PROJECT-26560465, KAKENHI-PROJECT-26282218, KAKENHI-PROJECT-26293209, KAKENHI-PLANNED-23111002, KAKENHI-ORGANIZER-15H05871, KAKENHI-PROJECT-15H01690

  • [Journal Article] RASAL3, a novel hematopoietic RasGAP protein, regulates the number and functions of NKT cells2015
    • Author(s)
      Saito S, Kawamura T, Higuchi M, Kobayashi T, Yoshita-Takahashi M, Yamazaki M, Abe M, Sakimura K, Kanda Y, Kawamura H, Jiang S, Naito M, Yoshizaki T, Takahashi M, Fujii M.
    • Journal Title

      Eur J Immunol

      Volume: in press Pages: 1512-1523

    • DOI

      10.1002/eji.201444977

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26461417, KAKENHI-PROJECT-26670222, KAKENHI-PROJECT-26460990, KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-15H04704

  • [Journal Article] The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer's disease.2015
    • Author(s)
      Watanabe K, Uemura K, Asada M, Maesako M, Akiyama H, Shimohama S, Takahashi R, Kinoshita A.
    • Journal Title

      Mol Brain.

      Volume: 4;8(1) Pages: 82-82

    • DOI

      10.1186/s13041-015-0174-2

    • NAID

      120005708017

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461270, KAKENHI-PLANNED-23111002

  • [Journal Article] Idiopathic normal pressure hydrocephalus has a different cerebrospinal fluid biomarker profile from Alzheimer's disease.2015
    • Author(s)
      Naoto Jingami, Megumi Asada-Utsugi, Kengo Uemura, Rio Noto, Makio Takahashi, Akihiko Ozaki, Takeshi Kihara, Takashi Kageyama, Ryosuke Takahashi, Shun Shimohama, Ayae Kinoshita.
    • Journal Title

      J Alzheimers Dis.

      Volume: 126（４） Pages: 109-115

    • DOI

      10.3233/jad-142622

    • NAID

      120005593597

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-ORGANIZER-23111001, KAKENHI-PROJECT-26461270, KAKENHI-PLANNED-23111002

  • [Journal Article] Potential interactions between pericytes and oligodendrocyte precursor cells in perivascular regions of cerebral white matter.2015
    • Author(s)
      Maki T, Maeda M, Uemura M, Lo EK, Terasaki Y, Liang AC, Shindo A, Choi YK, Taguchi A, Matsuyama T, Takahashi R, Ihara M, Arai K.
    • Journal Title

      Neurosci Lett.

      Volume: 597 Pages: 164-169

    • DOI

      10.1016/j.neulet.2015.04.047

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-23111002

  • [Journal Article] The Polymorphism of YWHAE, a Gene Encoding 14-3-3Epsilon, and Brain Morphology in Schizophrenia: A Voxel-Based Morphometric Study.2014
    • Author(s)
      Kido M, Nakamura Y, Nemoto K, Takahashi T, Aleksic B, Furuichi A, Nakamura Y, Ikeda M, Noguchi K, Kaibuchi K, Iwata N, Ozaki N, Suzuki M
    • Journal Title

      PLoS One

      Volume: 9

    • DOI

      10.1371/journal.pone.0103571

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-24390281, KAKENHI-PLANNED-25117010

  • [Journal Article] Focal Transplantation of Human iPSC-Derived Glial-Rich Neural Progenitors Improves Lifespan of ALS Mice.2014
    • Author(s)
      1.Kondo, T., Funayama, M., Tsukita, K., Hotta, A., Yasuda, A., Nori, S., Kaneko, S., Nakamura, M., Takahashi, R., Okano, H., Yamanaka, S., Inoue, H.
    • Journal Title

      Stem Cell Reports.

      Volume: 3 Pages: 1-8

    • DOI

      10.1016/j.stemcr.2014.05.017

    • NAID

      120005451806

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-22110007, KAKENHI-PLANNED-23111002, KAKENHI-PLANNED-26117007

  • [Journal Article] Transglutaminase 2 accelerates neuroinflammation in amyotrophic lateral sclerosis through interaction with misfolded superoxide dismutase 12014
    • Author(s)
      Oono M, Okado-Matsumoto A, Shodai A, Ido A, Ohta Y, Abe K, Ayaki T, Ito H, Takahashi R, Taniguchi N, Urushitani M.
    • Journal Title

      J Neurochem.

      Volume: 128（3） Pages: 403-18

    • DOI

      10.1111/jnc.12441

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-ORGANIZER-23111001, KAKENHI-PLANNED-23111002, KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-24300132

  • [Journal Article] Abnormal White Matter Integrity in the Corpus Callosum among Smokers2014
    • Author(s)
      Umene-Nakano W, Yoshimura R, Kakeda S, Watanabe K, Hayashi K, Nishimura J, Takahashi H, Moriya J, Ide S, Ueda I, Hori H, Ikenouchi-Sugita A, Katsuki A, Atake K, Abe O, Korogi Y, Nakamura J.
    • Journal Title

      PLoS ONE

      Volume: 9(2)

    • DOI

      10.1371/journal.pone.0087890

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-22220003, KAKENHI-PLANNED-23120009, KAKENHI-PROJECT-23680045, KAKENHI-PROJECT-24243061

  • [Journal Article] Common variants at 1p36 are associated with superior frontal gyrus volume2014
    • Author(s)
      Hashimoto R, Ikeda M, Yamashita F, Ohi K, Yamamori H, Yasuda Y, Fujimoto M, Fukunaga M, Nemoto K, Takahashi T, Tochigi M, Onitsuka T, Yamasue H, Matsuo K, Iidaka T, Iwata N, Suzuki M, Takeda M, Kasai K, Ozaki N
    • Journal Title

      Translational Psychiatry,

      Volume: 4

    • DOI

      10.1038/tp.2014.110

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-24390281, KAKENHI-PROJECT-24591716, KAKENHI-PROJECT-25293250, KAKENHI-PROJECT-25461730, KAKENHI-PROJECT-25861002, KAKENHI-PROJECT-26670541

  • [Journal Article] Immunoreactivity of valosin-containing protein in sporadic amyotrophic lateral sclerosis and in a case of its novel mutant.2014
    • Author(s)
      Ayaki T, Ito H, Fukushima H, Inoue T, Kondo T, Ikemoto A, Asano T, Shodai A, Fujita T, Fukui S, Morino H, Nakano S, Kusaka H, Yamashita H, Ihara M, Matsumoto R, Kawamata J, Urushitani M, Kawakami H, Takahashi R.
    • Journal Title

      Acta Neuropathol Commun.

      Volume: 2 Pages: 172-172

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24300132

  • [Journal Article] Proteomic analysis of Girdin-interacting proteins in migrating new neurons in the postnatal mouse brain2014
    • Author(s)
      Kohei Shimono, Kazuto Fujishima, Takafumi Nomura, Masayoshi Ohashi, Tadao Usui, Mineko Kengaku, Atsushi Toyoda, and Tadashi Uemura.
    • Journal Title

      Scientific Report

      Volume: 4 Pages: 16-21

    • DOI

      10.1038/srep04415

    • NAID

      120005399036

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-22115006, KAKENHI-PROJECT-221S0003, KAKENHI-PUBLICLY-24111525, KAKENHI-PROJECT-24500410, KAKENHI-PROJECT-221S0002

  • [Journal Article] Jan-Feb)XIAP immunoreactivity in glial and neuronal cytoplasmic inclusions in multiple system atrophy.Clin Neuropathol.2014
    • Author(s)
      Kawamoto Y, Ito H, Ihara M, Takahashi R.
    • Journal Title

      Clin Neuropathol.

      Volume: 33(1) Pages: 76-83

    • DOI

      10.5414/np300610

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-23111001, KAKENHI-PLANNED-23111002, KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-24300132

  • [Journal Article] Immunohistochemical localization of apoptosome-related proteins in Lewy bodies in Parkinson's disease and dementia with Lewy bodies.2014
    • Author(s)
      Kawamoto Y, Ito H, Ayaki T, Takahashi R.
    • Journal Title

      Brain Res.

      Volume: 1571 Pages: 39-48

    • DOI

      10.1016/j.brainres.2014.05.007

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24300132

  • [Journal Article] Design, evaluation and screening methods for efficient targeted mutagenesis with TALENs in medaka2014
    • Author(s)
      Ansai S, Inohaya K, Yoshiura Y, Manfred S, Uemura N, Takahashi R, Kinoshita, M
    • Journal Title

      Dev. Growth Differ

      Volume: 56 Pages: 98-107

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Journal Article] Speed control for neuronal migration in the postnatal brain by Gmip-mediated local inactivation of RhoA.2014
    • Author(s)
      Haruko Ota, Takao Hikita, Masato Sawada, Tomoki Nishioka, Mami Matsumoto, Masayuki Komura, Akihisa Ohno, Yukiyo Kamiya, Takuya Miyamoto, Naoya Asai, Atsushi Enomoto, Masahide Takahashi, Kozo Kaibuchi, Kazuya Sobue, Kazunobu Sawamoto
    • Journal Title

      Nat. Commun.

      Volume: 5 Pages: 4532-4532

    • DOI

      10.1038/ncomms5532

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-24390095, KAKENHI-PROJECT-24689021, KAKENHI-PLANNED-22122004, KAKENHI-PROJECT-26221304

  • [Journal Article] Involvement of Wnt/β-catenin signaling in the development of neuropathic pain.2014
    • Author(s)
      Itokazu T, Hayano Y, Takahashi R, Yamashita T.
    • Journal Title

      Neurosci. Res.

      Volume: 79 Pages: 34-40

    • DOI

      10.1016/j.neures.2013.12.002

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-ORGANIZER-23111001, KAKENHI-PLANNED-23111002, KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-25221309

  • [Journal Article] Protein Disulfide Isomerase P5-Immunopositive Inclusions in Patients with Alzheimer's Disease.2014
    • Author(s)
      Honjo Y, Horibe T, Torisawa A, Ito H, Nakanishi A, Mori H, Komiya T, Takahashi R, Kawakami K.
    • Journal Title

      J Alzheimers Dis.

      Volume: 38（3） Pages: 601-609

    • DOI

      10.3233/jad-130632

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-23111001, KAKENHI-PLANNED-23111002, KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-24300132, KAKENHI-PROJECT-25290018

  • [Journal Article] Design, evaluation and screening methods for efficient targeted mutagenesis with TALENs in medaka.2014
    • Author(s)
      S. Ansai, K. Inohaya, Y. Yoshiu ra, M. Schartl, N. Uemura, R. Takahashi, M. Kinoshita
    • Journal Title

      Dev. Growth Differ

      Volume: 56 Pages: 98-107

    • DOI

      10.1111/dgd.12104

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-13J01682, KAKENHI-ORGANIZER-23111001, KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-26670442

  • [Journal Article] Immunoreactivity of valosin-containing protein in sporadic amyotrophic lateral sclerosis and in a case of its novel mutant.2014
    • Author(s)
      Ayaki T, Ito H, Fukushima H, Inoue T, Kondo T, Ikemoto A, Asano T, Shodai A, Fujita T, Fukui S, Morino H, Nakano S, Kusaka H, Yamashita H, Ihara M, Matsumoto R, Kawamata J, Urushitani M, Kawakami H, Takahashi R.
    • Journal Title

      Acta Neuropathologica Comm

      Volume: 2 Pages: 172-172

    • DOI

      10.1186/s40478-014-0172-0

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24591259, KAKENHI-PROJECT-25860711, KAKENHI-PROJECT-26282218, KAKENHI-PROJECT-26290023, KAKENHI-PROJECT-26560465, KAKENHI-PLANNED-23111002

  • [Journal Article] Exploring the Pathogenetic Mechanisms underlying Parkinson's Disease in Medaka Fish2014
    • Author(s)
      Matsui H, Uemura N, Yamakado H, Takeda S, Takahashi R
    • Journal Title

      Journal of Parkinsons Disease

      Volume: 4 Pages: 301-310

    • DOI

      10.3233/jpd-130289

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-ORGANIZER-23111001, KAKENHI-PLANNED-23111002, KAKENHI-PROJECT-24790879, KAKENHI-PROJECT-26860666

  • [Journal Article] Immunostaining of oxidized DJ-1 in human and mouse brain.2014
    • Author(s)
      Saito, Y., T. Miyasaka, H. Hatsuta, K. Takahashi-Niki, K. Hayashi, Y. Mita, O. Kusano-Arai, H. Iwanari, H. Ariga, T. Hamakubo, Y. Yoshida, E. Niki, S. Murayama, Y. Ihara and N. Noguchi
    • Journal Title

      Journal of Neuropathology and Experimental Neurology

      Volume: 73 Pages: 714-28

    • DOI

      10.1097/nen.0000000000000087

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-221S0003, KAKENHI-PLANNED-24108007, KAKENHI-PROJECT-24790773, KAKENHI-PROJECT-25220205, KAKENHI-PROJECT-25670084

  • [Journal Article] Nardilysin prevents amyloid plaque formation by enhancing α-secretase activity in an Alzheimer’s disease mouse model2014
    • Author(s)
      Ohno M, Hiraoka Y, Lichtenthaler S, Nishi K, Saijo S, Matsuoka T, Tomimoto H, Araki W, Takahashi R, Kita T, Kimura T and Nishi E
    • Journal Title

      Neurobiology of Aging

      Volume: 35 Pages: 213-22

    • DOI

      10.1016/j.neurobiolaging.2013.07.014

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-23300117, KAKENHI-PROJECT-23390232, KAKENHI-PUBLICLY-24113713, KAKENHI-PROJECT-24700366, KAKENHI-PUBLICLY-25113710, KAKENHI-PUBLICLY-25122709, KAKENHI-PROJECT-25293182, KAKENHI-PROJECT-25670118

  • [Journal Article] RNA cytidine acetyltransferase of small-subunit ribosomal RNA: identification of acetylation sites and the responsible acetyltransferase in fission yeast, Schizosaccharomyces pombe.2014
    • Author(s)
      Taoka M, Ishikawa D, Nobe Y, Ishikawa H, Yamauchi Y, Terukina G, Nakayama H, Hirota K, Takahashi N, Isobe T
    • Journal Title

      PLoS One.

      Volume: 9

    • DOI

      10.1371/journal.pone.0112156

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-24241075, KAKENHI-PROJECT-25281021, KAKENHI-PUBLICLY-26116518

  • [Journal Article] Exploring the Pathogenetic Mechanisms underlying Parkinson's Disease in Medaka Fish.2013
    • Author(s)
      Matsui H, Uemura N, Yamakado H, Takeda S, Takahashi R
    • Journal Title

      J Parkinsons Dis.

      Volume: Epub ahead of print

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Journal Article] Genetic correction will be a standard method for the patient-derived ips cell research?2013
    • Author(s)
      Takahashi R, Yamakado H.
    • Journal Title

      Mov Disord.

      Volume: 28(14) Pages: 1935-1935

    • DOI

      10.1002/mds.25710

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-23111001, KAKENHI-PLANNED-23111002, KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-24790879

  • [Journal Article] Optineurin suppression causes neuronal cell death via NF-κB pathway.2013
    • Author(s)
      Akizuki M, Yamashita H, Uemura K, Maruyama H, Kawakami H, Ito H, Takahashi R.
    • Journal Title

      J Neurochem.

      Volume: 126(6) Pages: 2230-41

    • DOI

      10.1111/jnc.12326

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-ORGANIZER-23111001, KAKENHI-PLANNED-23111002, KAKENHI-PLANNED-23111008, KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-23591246, KAKENHI-PROJECT-24300132, KAKENHI-PROJECT-24591259

  • [Journal Article] PINK1 and Parkin complementarily protect dopaminergic neurons in vertebrates2013
    • Author(s)
      Matsui H, Gavinio R, Asano T, Uemura N, Ito H, Taniguchi Y, Kobayashi Y, Maki T, Shen J, Takeda S, Uemura K, Yamakado H, Takahashi R
    • Journal Title

      Hum Mol Genet

      Volume: 22 Pages: 2423-34

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Journal Article] Modeling Alzheimer' s disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness2013
    • Author(s)
      Kondo T, Asai M, Tsukita K, Kutoku Y, Ohsawa Y, Sunada Y, Imamura K, Egawa N, Yahata N, Okita K, Takahashi K, Asaka I, Aoi T, Watanabe A, Watanabe K, Kadoya C, Nakano R, Watanabe D, Maruyama K, Hori O, Hibino S, Choshi T, Nakahata T, Hioki H, Kaneko T, Naitoh M, Yoshikawa K, Yamawaki S, Suzuki S, Hata R, Ueno S, Seki T, Kobayashi K, Toda T, Murakami K, Irie K, Klein WL, Mori H, Asada T, Takahashi R, Iwata N, Yamanaka S, Inoue H
    • Journal Title

      Cell Stem Cell

      Volume: 12 Pages: 487-96

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Journal Article] A progressive dopaminergic phenotype associated with neurotoxic conversion of α -synuclein in BAC-transgenic rats2013
    • Author(s)
      Nuber S, Harmuth F, Kohl Z, Adame A, Trejo M, Schönig K, Zimmermann F, Bauer C, Casadei N, Giel C, Calaminus C, Pichler BJ, Jensen PH, Müller CP, Amato D, Kornhuber J, Teismann P, Yamakado H, Takahashi R, Winkler J, Masliah E, Riess O
    • Journal Title

      Brain

      Volume: 136 Pages: 412-32

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Journal Article] Copper enhances APP dimerization and promotes Aβ production2013
    • Author(s)
      Noda Y, Asada M, Kubota M, Maesako M, Watanabe K, Uemura M, Kihara T, Shimohama S, Takahashi R, Kinoshita A, Uemura K
    • Journal Title

      Neurosci Lett.

      Volume: 547 Pages: 10-15

    • DOI

      10.1016/j.neulet.2013.04.057

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22390180, KAKENHI-ORGANIZER-23111001, KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-23659460, KAKENHI-PUBLICLY-24111524

  • [Journal Article] Synthesis and Biological Evaluation of Novel Styryl Benzimidazole Derivatives as Probes for Imaging of Neurofibrillary Tangles in Alzheimer’s Disease.2013
    • Author(s)
      Matsumura K, Ono M, Yoshimura M, Kimura H, Watanabe H, Okamoto Y, Ihara M, Takahashi R, Saji H.
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 21 Pages: 3356-3362

    • DOI

      10.1016/j.bmc.2013.02.054

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-23390233, KAKENHI-PROJECT-24659564, KAKENHI-PROJECT-25640031

  • [Journal Article] Tricornered/NDR kinase signaling mediates PINK1-directed mitochondrial quality control and tissue maintenance.2013
    • Author(s)
      Wu Z, Sawada T, Shiba K, Liu S, Kanao T, Takahashi R, Hattori N, Imai Y, Lu B. .
    • Journal Title

      Genes & Developments

      Volume: 27 Pages: 157-162

    • DOI

      10.1101/gad.203406.112

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-23111003, KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-23790973, KAKENHI-PROJECT-24790896

  • [Journal Article] S-nitrosylation regulates mitochondrial quality control via activation of parkin2013
    • Author(s)
      Ozawa K, Komatsubara AT, Nishimura Y, Sawada T, Kawafune H, Tsumoto H, Tsuji Y, Zhao J, Kyotani Y, Tanaka T, Takahashi R, Yoshizumi M
    • Journal Title

      Sci Rep

      Volume: 3 Pages: 2202-2202

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Journal Article] Exploring the Pathogenetic Mechanisms underlying Parkinson' s Disease in Medaka Fish2013
    • Author(s)
      Matsui H, Uemura N, Yamakado H, Takeda S, Takahashi R
    • Journal Title

      J Parkinsons

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Journal Article] Efficient targeted mutagenesis in medaka using custom-designed transcription activator-like effector nucleases2013
    • Author(s)
      Ansai S, Sakuma T, Yamamoto T, Ariga H, Uemura N, Takahashi R, Kinoshita M
    • Journal Title

      Genetics

      Volume: 193 Pages: 739-49

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Journal Article] Modeling Alzheimer's Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness.2013
    • Author(s)
      Kondo, T., (他24名), Murakami, K., Irie, K., Klein, W. L., Mori, H., Asada, T., Takahashi, R., Iwata, N., Yamanaka, S., Inoue, H
    • Journal Title

      Cell Stem Cell.

      Volume: 12 Pages: 780-4

    • DOI

      10.1016/j.stem.2013.01.009

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21248015, KAKENHI-PLANNED-22129006, KAKENHI-ORGANIZER-23111001, KAKENHI-PLANNED-23111002, KAKENHI-PROJECT-23249049, KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-23592093, KAKENHI-PROJECT-24220009, KAKENHI-PROJECT-24500408, KAKENHI-PROJECT-24590040, KAKENHI-PROJECT-24700367, KAKENHI-PROJECT-24790260, KAKENHI-PROJECT-24790276, KAKENHI-PUBLICLY-25123709, KAKENHI-PROJECT-25290018, KAKENHI-PROJECT-25460341, KAKENHI-PUBLICLY-23110535, KAKENHI-PUBLICLY-23123510

  • [Journal Article] Aberrant assembly of RNA recognition motif 1 links to pathogenic conversion of TAR DNA-binding protein of 43 kDa (TDP-43).2013
    • Author(s)
      Shodai A, Morimura T, Ido A, Uchida T, Ayaki T, Takahashi R, Kitazawa S, Suzuki S, Shirouzu M, Kigawa T, Muto Y, Yokoyama S, Takahashi R, Kitahara R, Ito H, Fujiwara N, Urushitani M
    • Journal Title

      J Biol Chem.

      Volume: 288(21) Pages: 14886-14905

    • DOI

      10.1074/jbc.m113.451849

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-ORGANIZER-23111001, KAKENHI-PLANNED-23111002, KAKENHI-PROJECT-23370080, KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-23580417, KAKENHI-PROJECT-23591259, KAKENHI-PROJECT-24300132, KAKENHI-PROJECT-25840025

  • [Journal Article] The function of parkin: revisited.2013
    • Author(s)
      Yamakado H, Takahashi R.
    • Journal Title

      Mov Disord.

      Volume: 28(14) Pages: 1936-1936

    • DOI

      10.1002/mds.25711

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-23111001, KAKENHI-PLANNED-23111002, KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-24790879

  • [Journal Article] Continuation of exercise is necessary to inhibit high fat diet-induced beta-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice2013
    • Author(s)
      Masato Maesako, Kengo Uemura, Ayana Iwata, Masakazu Kubota, Kiwamu Watanabe, Maiko Uemura, Yasuha Noda, Megumi Asada-Utsugi, Takeshi Kihara, Ryosuke Takahashi, Shun Shimohama and Ayae Kinoshita.
    • Journal Title

      Plos One

      Volume: 8

    • DOI

      10.1371/journal.pone.0072796

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-13J00221, KAKENHI-PROJECT-22390180, KAKENHI-ORGANIZER-23111001, KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-23659460, KAKENHI-PUBLICLY-24111524

  • [Journal Article] Tricornered/NDR kinase signaling mediates PINK1-directed mitochondrial quality control and tissue maintenance2013
    • Author(s)
      Wu Z, Sawada T, Shiba K, Liu S, Kanao T, Takahashi R, Hattori N, Imai Y, Lu B
    • Journal Title

      Genes Dev

      Volume: 27 Pages: 157-62

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Journal Article] ATP13A2 deficiency induces a decrease in cathepsin D activity, fingerprint-like inclusion body formation, and selective degeneration of dopaminergic neurons2013
    • Author(s)
      Matsui H, Sato F, Sato S, Koike M, Taruno Y, Saiki S, Funayama M, Ito H, Taniguchi Y, Uemura N, Toyoda A, Sakaki Y, Takeda S, Uchiyama Y, Hattori N, Takahashi R
    • Journal Title

      FEBS Lett

      Volume: 587 Pages: 1316-25

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Journal Article] Loss of TDP-43 causes age-dependent progressive motor neuron degeneration.2013
    • Author(s)
      Iguchi Y
    • Journal Title

      Brain.

      Volume: 136 Pages: 1371-1382

    • DOI

      10.1093/brain/awt029

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22390175, KAKENHI-PROJECT-22590965, KAKENHI-ORGANIZER-23111001, KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-23659452, KAKENHI-PROJECT-25293020, KAKENHI-PLANNED-22110005

  • [Journal Article] Chronic overload of SEPT4, a parkin substrate that aggregates in Parkinson’s disease, causes behavioral alterations but not neurodegeneration in mice.2013
    • Author(s)
      Ageta-Ishihara N, Yamakado H, Morita T, Hattori S, Takao K, Miyakawa T, Takahashi R, Kinoshita M
    • Journal Title

      Molecular brain

      Volume: 6 Pages: 35-35

    • DOI

      10.1186/1756-6606-6-35

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-ORGANIZER-23111001, KAKENHI-PROJECT-23370084, KAKENHI-PROJECT-23390232, KAKENHI-PUBLICLY-24111546, KAKENHI-PROJECT-24770184, KAKENHI-PROJECT-24790879, KAKENHI-PUBLICLY-25116526, KAKENHI-PROJECT-25350989

  • [Journal Article] Exploring the Pathogenetic Mechanisms underlying Parkinson's Disease in Medaka Fish.2013
    • Author(s)
      Matsui H, Uemura N, Yamakado H, Takeda S, Takahashi R.
    • Journal Title

      J Parkinsons Dis.

      Volume: 4(2) Pages: 301-310

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Journal Article] Chicken DT40 cell line lacking DJ-1, the gene responsible for familial Parkinson's disease, displays mitochondrial dysfunction.2013
    • Author(s)
      Minakawa EN, Yamakado H, Tanaka A, Uemura K, Takeda S, Takahashi R
    • Journal Title

      Neurosci Res.

      Volume: 77 Pages: 228-233

    • DOI

      10.1016/j.neures.2013.09.006

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-23390232, KAKENHI-PUBLICLY-24111513, KAKENHI-PROJECT-24790879

  • [Journal Article] ATP13A2 deficiency induces a decrease in cathepsin D activity, fingerprint-like inclusion body formation, and selective degeneration of dopaminergic neurons2013
    • Author(s)
      Matsui H, Sato F, Sato S, Koike M, Taruno Y, Saiki S, Funayama M, Ito H, Taniguchi Y, Uemura N, Toyoda A, Sakaki Y, Takeda S, Uchiyama Y, Hattori N, Takahashi R.
    • Journal Title

      FEBS Letters

      Volume: 587(9) Pages: 1316-1325

    • DOI

      10.1016/j.febslet.2013.02.046

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-ORGANIZER-23111001, KAKENHI-PLANNED-23111002, KAKENHI-PLANNED-23111003, KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-23590244, KAKENHI-PROJECT-23689046, KAKENHI-PROJECT-23790238, KAKENHI-PROJECT-24300132, KAKENHI-PROJECT-24390224, KAKENHI-PROJECT-24659435, KAKENHI-PUBLICLY-25129707, KAKENHI-PROJECT-25461291, KAKENHI-PUBLICLY-23129506

  • [Journal Article] Role of posterior parietal cortex in reaching movements in humans: Clinical implication for 'optic ataxia'.2013
    • Author(s)
      Minakawa EN, Yamakado H, Tanaka A, Uemura K, Takeda S, Takahashi R.
    • Journal Title

      Clinical Neurophysiology

      Volume: 77(4) Pages: 2230-2241

    • DOI

      10.1016/j.clinph.2013.05.011

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-23111001, KAKENHI-PLANNED-23111002, KAKENHI-PROJECT-23591273, KAKENHI-PROJECT-23591275, KAKENHI-PROJECT-25861273

  • [Journal Article] PINK1 and Parkin complementarily protect dopaminergic neurons in vertebrates.2013
    • Author(s)
      Matsui H, Gavinio R, Asano T, Uemura N, Ito H, Taniguchi Y, Kobayashi Y, Maki T, Shen J, Takeda S, Uemura K, Yamakado H, Takahashi R.
    • Journal Title

      Hum Mol Genet.

      Volume: 22(12) Pages: 1-1

    • DOI

      10.1093/hmg/ddt095

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-ORGANIZER-23111001, KAKENHI-PLANNED-23111002, KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-24300132, KAKENHI-PROJECT-24790879

  • [Journal Article] Response to comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells"2013
    • Author(s)
      Egawa N, Kitaoka S, Tsukita K, Naitoh M, Takahashi K, Yamamoto T, Adachi F, Kondo T, Okita K, Asaka I, Aoi T, Watanabe A, Yamada Y, Morizane A, Takahashi J, Ayaki T, Ito H, Yoshikawa K, Yamawaki S, Suzuki S, Watanabe D, Hioki H, Kaneko T, Makioka K, Okamoto K, Takuma H, Tamaoka A, Hasegawa K, Nonaka T, Hasegawa
    • Journal Title

      Sci Transl Med

      Volume: 5(188)

    • DOI

      10.1126/scitranslmed.3005697

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-ORGANIZER-23111001, KAKENHI-PLANNED-23111002, KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-24591249

  • [Journal Article] Development of Novel 123I-Labeled Pyridyl Benzofuran Derivatives for SPECT Imaging of β-Amyloid Plaques in Alzheimer's Disease.2013
    • Author(s)
      Ono M, Cheng Y, Kimura H, Watanabe H, Matsumura K, Yoshimura M, Iikuni S, Okamoto Y, Ihara M, Takahashi R, Saji H.
    • Journal Title

      PLoS ONE

      Volume: 8

    • DOI

      10.1371/journal.pone.0074104

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-23390233, KAKENHI-PROJECT-25640031

  • [Journal Article] Response to Comment on "Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells".2013
    • Author(s)
      Egawa, N., Kitaoka, S., Tsukita, K., Naitoh, M., Takahashi, K., Yamamoto, T., Adachi, F., Kondo, T., Okita, K., Asaka, I., Aoi, T., Watanabe, A., Yamada, Y., Morizane, A., Takahashi, J., Ayaki, T., Ito, H., Yoshikawa, K., Yamawaki, S., Suzuki, S., Watanabe, D., Hioki, H., Kaneko, T., Makioka, K., Okamoto, K., Takuma, H., Tamaoka, A., Hasegawa, K., Nonaka, T., Hasegawa, M., Kawata, A., Yoshida, M., Nakahata, T., Takahashi, R., Marchetto, M. C. N., Gage, F. H., Yamanaka, S., and Inoue, H
    • Journal Title

      Science Translational Medicine

      Volume: 4 Pages: 145-104

    • DOI

      10.1126/scitranslmed.3004052

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21228003, KAKENHI-PLANNED-22110007, KAKENHI-PROJECT-23240050, KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-24220009, KAKENHI-PROJECT-24300132, KAKENHI-PROJECT-24500408, KAKENHI-PROJECT-24591249, KAKENHI-PROJECT-24592124, KAKENHI-PROJECT-24790276, KAKENHI-PUBLICLY-23110526, KAKENHI-ORGANIZER-23111001, KAKENHI-PLANNED-23111002, KAKENHI-PUBLICLY-23123510

  • [Journal Article] Parkin interacts with Klokin1 for mitochondrial import and maintenance of membrane potential2012
    • Author(s)
      Takeuchi H, Iba M, Inoue H, Higuchi M, Takao K, Tsukita K, Karatsu Y, Kuroda Y, Sako W, Goto S, Sawada T, Uchida D, Izumi Y, Takahashi T, Kagawa N, Matsumoto M, Matsumoto M, Takahashi R, Kaji R, Mitsui T
    • Journal Title

      Hum Mol Genet

      Volume: 21 Pages: 991-1003

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Journal Article] Motor Neuron-specific Disruption of Proteasomes, but not Autophagy, Replicates Amyotrophic Lateral Sclerosis2012
    • Author(s)
      Y. Tashiro
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 287 Pages: 42984-42994

    • DOI

      10.1074/jbc.m112.417600

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590930, KAKENHI-PROJECT-23300131, KAKENHI-PROJECT-23390041, KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-23659102, KAKENHI-PROJECT-23790238, KAKENHI-PROJECT-24300132, KAKENHI-PROJECT-24700321, KAKENHI-PLANNED-22110007, KAKENHI-ORGANIZER-23111001, KAKENHI-PLANNED-23111002, KAKENHI-PLANNED-23111004

  • [Journal Article] Immunohistochemical localization of X-linked inhibitor of apoptosis protein in brainstem-type and cortical Lewy bodies2012
    • Author(s)
      Kawamoto Y, Ito H, Ihara M, Takahashi R
    • Journal Title

      NeuroReport

      Volume: 23:162-167 Pages: 162-167

    • DOI

      10.1097/wnr.0b013e32834f4066

    • NAID

      120005244628

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590930

  • [Journal Article] The Nitric Oxide-Cyclic GMP Pathway Regulates FoxO and Alters Dopaminergic Neuron Survival in Drosophila2012
    • Author(s)
      Kanao T, Sawada T, Davies SA, Ichinose H, Hasegawa K, Takahashi R, Hattori N, Imai Y
    • Journal Title

      PLoS One

      Volume: 7(2)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Journal Article] Conserved Acidic Amino Acid Residues in a Second RNA Recognition Motif Regulate Assembly and Function of TDP-43.2012
    • Author(s)
      Shodai A
    • Journal Title

      PLoS One

      Volume: 7

    • DOI

      10.1371/journal.pone.0052776

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23300131, KAKENHI-PROJECT-23580417, KAKENHI-PROJECT-23591259, KAKENHI-PROJECT-24300132, KAKENHI-PLANNED-23111002

  • [Journal Article] Cilostazol a phosphodiesterase in hibitor, prevents no-reflow and hemorrhage in mice with focal cerebral ischemia2012
    • Author(s)
      Hase Y, Okamoto Y, Fujita Y, KitamuraA, Ito H, Maki T, Washida K, TakahashiR, Ihara M
    • Journal Title

      Exp Neurol

      Volume: 233 Pages: 523-533

    • DOI

      10.1016/j.expneurol.2011.11.038

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21500336, KAKENHI-PROJECT-23390233, KAKENHI-PROJECT-23650182

  • [Journal Article] α -synuclein BAC transgenic mice as a model for Parkinson' s disease manifested decreased anxiety-like behavior and hyperlocomotion2012
    • Author(s)
      Yamakado H, Moriwaki Y, Yamasaki N, Miyakawa T, Kurisu J, Uemura K, Inoue H, Takahashi M, Takahashi R
    • Journal Title

      Neurosci Res

      Volume: 73 Pages: 173-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Journal Article] Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells2012
    • Author(s)
      Egawa N, Kitaoka S, Tsukita K, Naitoh M, Takahashi K, Yamamoto T, Adachi F, Kondo T, Okita K, Asaka I, Aoi T, Watanabe A, Yamada Y, Morizane A, Takahashi J, Ayaki T, Ito H, Yoshikawa K, Yamawaki S, Suzuki S, Watanabe D, Hioki H, Kaneko T, Makioka K, Okamoto K, Takuma H, Tamaoka A, Hasegawa K, Nonaka T, Hasegawa M, Kawata A, Yoshida M, Nakahata T, Takahashi R, Marchetto MC, Gage FH, Yamanaka S, Inoue H
    • Journal Title

      Sci Transl Med

      Volume: 4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Journal Article] Parkin pathway activation mitigates glioma cell proliferation and predicts patient survival2012
    • Author(s)
      Yeo CW, Ng FS, Chai C, Tan JM, Koh GR, Chong YK, Koh LW, Foong CS, Sandanaraj E, Holbrook JD, Ang BT, Takahashi R, Tang C, Lim KL
    • Journal Title

      Cancer Res

      Volume: 72 Pages: 2543-2253

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Journal Article] 神経疾患に対する細胞治療の開発-現状と展望2012
    • Author(s)
      高橋良輔、近藤孝之
    • Journal Title

      臨床神経学

      Volume: (印刷中)

    • Data Source
      KAKENHI-PUBLICLY-23110507

  • [Journal Article] Parkinson' s Disease-Associated Kinase PINK1 Regulates Miro Protein Level and Axonal Transport of Mitochondria2012
    • Author(s)
      Liu S, Sawada T, Lee S, Yu W, Silverio G, Alapatt P, Millan I, Shen A, Saxton W, Kanao T, Takahashi R, Hattori N, Imai Y, Lu B
    • Journal Title

      PLoS Genet

      Volume: 8(3)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Journal Article] The TRK-fused gene is mutated in hereditary motor and sensory neuropathy with proximal do minant involvement.2012
    • Author(s)
      Ishiura H, Sako W, Yoshida M, Kawarai T, Tanabe O, Goto J, Takahashi Y, Date H, Mitsui J, Ahsan B, Ichikawa Y, Iwata A, Yoshino H, Izumi Y, Fujita K, Maeda K, Goto S, Koizumi H, Morigaki R, Ikemura M, Yamauchi N, Murayama S, Nicholson GA, Ito H, Sobue G, Nakagawa M, Kaji R, Tsuji S.
    • Journal Title

      Am J Hum Genet.

      Volume: 91 Pages: 320-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-221S0003

  • [Journal Article] Selective white matter abnormalities in a novel rat model of vascular dementia2012
    • Author(s)
      Kitamura A, Fujita Y, Oishi N, KalariaR N, Washida K, Maki T, Okamoto Y, HaseY, Yamada M, Takahashi J, Ito H, Tomimoto H, Fukuyama H, Takahashi R, Ihara M
    • Journal Title

      Neurobiol Aging

      Volume: 33 Pages: 25-35

    • DOI

      10.1016/j.neurobiolaging.2011.10.033

    • NAID

      120003988349

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21500336, KAKENHI-PROJECT-22220003, KAKENHI-PROJECT-23390233, KAKENHI-PROJECT-23650182

  • [Journal Article] Chemical library screeningidentifies a small molecule that downregulates SOD1 transcription for drugs to treat ALS.2011
    • Author(s)
      Murakami G, Inoue H, Tsukita K, Asai Y, Amagai Y, Aiba K, Shimogawa H, Uesugi M, Nakatsuji N, Takahashi R
    • Journal Title

      J Biomol Screen. (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390244

  • [Journal Article] Protein disulfide isomerase immuno positive glial cytoplasmic inclusions in patients with multiple system atrophy2011
    • Author(s)
      Honjo Y, Ito H, Horibe T, Takahashi R, Kawakami K
    • Journal Title

      International Journal of Neuroscience

    • DOI

      10.3109/00207454.2011.585440

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21500336

  • [Journal Article] Angiogenic roles of adrenomedullin through VEGF induction2011
    • Author(s)
      Maki T, Ihara M, Fujita Y, Nambu T, Harada H, Ito H, Nakao K, Tomimoto H, Takahashi R
    • Journal Title

      Neuroreport

      Volume: 22 Pages: 442-447

    • DOI

      10.1097/wnr.0b013e32834757e4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21500336, KAKENHI-PROJECT-23390233, KAKENHI-PROJECT-23650182

  • [Journal Article] Single and local blockade of IL-6 signaling promotes neuronal differentiation of transplanted ES cell-derived neural precursor cells.2011
    • Author(s)
      Gomi M, Aoki T, Takagi Y, Nishimura M, Ohsugi Y, Mihara M, Nozaki K, Hashimoto N, Miyamoto S, Takahashi J.
    • Journal Title

      J Neurosci Res (in press)

    • Data Source
      KAKENHI-PROJECT-20390383

  • [Journal Article] Optineurinis is co-localized with FUS in basophilic inclusions of ALS with FUS mutation and in basophilic inclusion body disease2011
    • Author(s)
      Ito H, Fujita K, Nakamura M, Wate R, Kaneko S, Sasaki S, Yamane K, Suzuki N, Aoki M, Shibata N, Togashi S, Kawata A, Mochizuki Y, Mizutani T, Maruyama H, Hirano A, Takahashi R, Kawakami H, Kusaka H
    • Journal Title

      Acta Neuropathol

      Volume: 121 Pages: 555-557

    • DOI

      10.1007/s00401-011-0809-z

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21500336, KAKENHI-PROJECT-22390429, KAKENHI-PROJECT-22590930, KAKENHI-PROJECT-22590965

  • [Journal Article] N-cadherin regulates p38MAPK signaling via association with JLP:Implications for neurodegeneration in Alzheimer's disease.2011
    • Author(s)
      Ando K, Uemura K, Kuzuy A, Kubota M, Maesako M, Asada M, Takahashi R, Kinoshita A
    • Journal Title

      J Biol Chem. 286

      Pages: 7619-7628

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390244

  • [Journal Article] An autopsy case of SOD1-related ALS with TDP-43 positiveinclusions2011
    • Author(s)
      Okamoto Y, Ihara M, Urushitani M, Yamashita H, Kondo T, Tanigaki A, Oono M, Kawamata J, Ikemoto A, Kawamoto Y, Takahashi R, Ito H
    • Journal Title

      Neurology

      Volume: 77:1993-1995 Pages: 1993-1995

    • DOI

      10.1212/wnl.0b013e31823a0cfc

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590930, KAKENHI-PROJECT-22659171, KAKENHI-PLANNED-23111002, KAKENHI-PROJECT-23300131, KAKENHI-PROJECT-23390233, KAKENHI-PROJECT-23650182

  • [Journal Article] Parkin interacts with Klokin1 for mitochondrial import and maintenance of membrane potential2011
    • Author(s)
      Kuroda Y, Takahashi R, et al
    • Journal Title

      Hum Mol Genet

      Volume: (Epub ahead of print)

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-23110507

  • [Journal Article] 再生医療とiPS細胞2011
    • Author(s)
      近藤孝之, 高橋良輔, 井上治久
    • Journal Title

      Clinical Neuroscience

      Volume: 29(9) Pages: 1055-105

    • Data Source
      KAKENHI-PROJECT-21591079

  • [Journal Article] Protein disulfide isomerase immunopositivei nclusions in patients with amyotrophic lateral sclerosis2011
    • Author(s)
      Honjo Y, Kaneko S, Ito H, Horibe T, Takahashi R, Kawakami K
    • Journal Title

      Amyotrophic lateral sclerosis

      Volume: 12 Pages: 444-450

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/22174512

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21500336

  • [Journal Article] Watershed infarcts in a multiple microembolic model of monkey2011
    • Author(s)
      Maki T, Wakita H, Mase M, Itagaki I, Saito N, Ono F, Adachi K, Ito H, Takahashi R, Ihara M, Tomimoto H
    • Journal Title

      Neurosci Lett

      Volume: 499 Pages: 80-83

    • DOI

      10.1016/j.neulet.2011.05.036

    • NAID

      120003238944

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21500336, KAKENHI-PROJECT-21591106, KAKENHI-PROJECT-23390233, KAKENHI-PROJECT-23650182

  • [Journal Article] P301S mutant human tau transgenic mice manifest early symptoms of human tauopathies with dementia and altered sensorimotor gating2011
    • Author(s)
      Takeuchi H, Takahashi R, et al
    • Journal Title

      PLoS One

      Volume: 6(Epub)

    • NAID

      120003255671

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-23110507

  • [Journal Article] The endoplasmic reticulum stress sensor, ATF6, protects against neurotoxin-induced dopaminergic neuronal death2011
    • Author(s)
      Egawa N, Yamamoto K, Inoue H, Hikawa R, Nishi K, Mori K, Takahashi R
    • Journal Title

      J Biol Chem

      Volume: 286 Pages: 7947-57

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Journal Article] Chemical library screening identifies a small molecule that downregulates SOD1 transcription for drugs to treat amyotrophic lateral sclerosis2011
    • Author(s)
      Murakami G, Inoue H, Tsukita K, Asai Y, Amagai Y, Aiba K, Shimogawa H, Uesugi M, Nakatsuji N, Takahashi R
    • Journal Title

      J Biomol Screen

      Volume: 16 Pages: 405-14

    • NAID

      120004225661

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Journal Article] The influence of chronic cerebral hypoperfusion on cognitive function and amyloid β metabolism in APP overexpressing mice2011
    • Author(s)
      Yamada M, Ihara M, Okamoto Y, Maki T, Washida K, Kitamura A, Hase Y, Ito H, Takao K, Miyakawa T, Kalaria RN, Tomimoto H, Takahashi R
    • Journal Title

      PLoS ONE

      Volume: 6

    • DOI

      10.1371/journal.pone.0016567

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21500336, KAKENHI-PROJECT-23390233

  • [Journal Article] Clinicopathological study on an ALS family with a heterozygous E478G optineurin mutation2011
    • Author(s)
      Ito H, Nakamura M, Komure O, Ayaki T, Wate R, Maruyama H, Nakamura Y, FujitaK, Kaneko S, Okamoto Y, Ihara M, Konishi T, Ogasawara K, Hirano A, Kusaka H, KajiR, Takahashi R, Kawakami H
    • Journal Title

      Acta Neuropathol

      Volume: 122 Pages: 223-229

    • DOI

      10.1007/s00401-011-0842-y

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21500336, KAKENHI-PROJECT-22590930, KAKENHI-PLANNED-23111002, KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-23390233, KAKENHI-PROJECT-23591246, KAKENHI-PROJECT-23650182

  • [Journal Article] The FOXE1 and NKX2-1loci are associated with susceptibility to papillary thyroid carcinoma in the Japanese population.2011
    • Author(s)
      Matsuse M, Takahashi M, Mitsutake N, Saenko V, Bychkov A, Suzuki K, Matsuo K, Yamashita S, et al
    • Journal Title

      J Med Genet

      Volume: 48(9) Pages: 645-648

    • DOI

      10.1136/jmedgenet-2011-100063

    • NAID

      120006985044

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22256004, KAKENHI-PROJECT-22390189, KAKENHI-PROJECT-22791204, KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-23590379

  • [Journal Article] Angiogenic and vasoprotective effects of adreno medulin on prevention of cognitive decline after chronic cerebral hypoperfusion in mice2011
    • Author(s)
      Tomimoto H
    • Journal Title

      Stroke

      Volume: 42(4) Pages: 1122-1128

    • DOI

      10.1161/strokeaha.110.603399

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21256005, KAKENHI-PROJECT-21500336, KAKENHI-PROJECT-23390233, KAKENHI-PROJECT-23650182

  • [Journal Article] The endoplasmic reticulum stress sensor, ATF6{alpha}, protects against neurotoxin-induced dopaminergic neuronal death.2011
    • Author(s)
      Egawa N, Yamamoto K, Inoue H, Hikawa R, Nishi K, Mori K,Takahashi R.
    • Journal Title

      J Biol Chem. 286

      Pages: 7947-7957

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390244

  • [Journal Article] Colocalization of 14-3-3 proteins with SOD1 in Lewy body-like hyaline inclusions in familial amyotrophic lateral sclerosis cases and the animal model2011
    • Author(s)
      Okamoto Y, Shirakashi Y, Ihara M, Urushitani M, Oono M, Kawamoto Y, Yamashita H, Shimohama S, Kato S, Hirano A, Tomimoto H, Ito H, Takahashi R
    • Journal Title

      PLoS ONE

      Volume: 6

    • DOI

      10.1371/journal.pone.0020427

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21500336, KAKENHI-PROJECT-22590930, KAKENHI-PROJECT-22659171, KAKENHI-PLANNED-23111002, KAKENHI-PROJECT-23300131, KAKENHI-PROJECT-23390233, KAKENHI-PROJECT-23650182

  • [Journal Article] Single and local blockade of IL-6 signaling promotes neuronal differentiation of transplanted ES cell-derived neural precursor cells.2011
    • Author(s)
      Gomi M, Aoki T, Takagi Y, Nishimura M, Ohsugi Y, Mihara M, Nozaki K, Hashimoto N, Miyamoto S, Takahashi J.
    • Journal Title

      J Neurosci Res

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390383

  • [Journal Article] Chemical library screening identifies a small molecule that down regulates SOD1 transcription for drugs to treat ALS2011
    • Author(s)
      Murakami G, Inoue H, Tsukita K, Asai Y, Amagai Y, Aiba K, Shimogawa H, Uesugi M, Nakatsuji N, Takahashi R
    • Journal Title

      The Journal of Biomolecular Screening

      Volume: 16(4) Pages: 405-414

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591079

  • [Journal Article] Proteasome inhibition in medaka brain induces the features of Parkinson disease2010
    • Author(s)
      Matsui H, Ito H, Taniguchi Y, Inoue H, Takeda S, Takahashi R
    • Journal Title

      Journal of Neurochemistry

      Volume: 115 Pages: 178-187

    • DOI

      10.1111/j.1471-4159.2010.06918.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21500336

  • [Journal Article] HtrA2/ Omi immunoreactive neuronal inclusions in the anterior horn of patients with sporadic and Cu/Zn superoxide dismutase (SOD1) mutant amyotrophic lateral sclerosis2010
    • Author(s)
      Kawamoto Y, Ito H, Kobayashi Y, Suzuki Y, Akiguchi I, Fujimura H, Sakoda S, Kusaka H, Hirano A, Takahashi R
    • Journal Title

      Neuropathology and Applied Neurobiology

      Volume: 36 Pages: 331-344

    • DOI

      10.1111/j.1365-2990.2010.01075.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21500336, KAKENHI-PROJECT-22590930

  • [Journal Article] Loss of PINK1 in medaka fish (Oryzias latipes) causes late-onset decrease in spontaneous movement.2010
    • Author(s)
      Matsui H, Taniguchi Y, Inoue H, Kobayashi Y, Sakaki Y, Toyoda A, Uemura K, Kobayashi D, Takeda S, Takahashi R
    • Journal Title

      Neurosci Res. 66

      Pages: 151-161

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390244

  • [Journal Article] Nonhypotensive Dose of Telmisartan Attenuates Cognitive Impairment Partially due to Peroxisome Proliferator-Activated Receptor-γ Activation in Mice with Chronic Cerebral Hypoperfusion.2010
    • Author(s)
      Washida K, Ihara M, Nishio K, Fujita Y, Maki T, Yamada M, Takahashi J, Wu X, Kihara T, Ito H, Tomimoto H, Takahashi R.
    • Journal Title

      Stroke 41

      Pages: 1798-1806

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390244

  • [Journal Article] Induced loss of ADAR2 engenders slow death of motor neurons from Q/R site-unedited GluR2.2010
    • Author(s)
      Hideyama T, Yamashita T, Suzuki T, Tsuji S, Higuchi M, Seeburg PH, Takahashi R, Misawa H, Kwak S.
    • Journal Title

      J Neurosci. 30

      Pages: 11917-11925

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390244

  • [Journal Article] PI3K inhibition causes the accumulation of ubiquitinated presenilin 1 without affecting the proteasome activity.2010
    • Author(s)
      Aoyagi N, Uemura K, Kuzuya A, Kihara T, Kawamata J, Shimohama S, Kinoshita A, Takahashi R
    • Journal Title

      Biochem. Biophys. Res.Commun. 391

      Pages: 1240-1245

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390244

  • [Journal Article] Proteasome inhibition in medaka brain induces the features of Parkinson disease.2010
    • Author(s)
      Matsui H, Ito H, Inoue H, Taniguchi Y, Takeda S, Takahashi R.
    • Journal Title

      J Neurochem. 115

      Pages: 178-187

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390244

  • [Journal Article] Localization of HtrA2/Omi immunoreactivity in brains affected by Alzheimer's disease2010
    • Author(s)
      Kawamoto Y, Ito H, Ihara M, Kobayashi Y, Suzuki Y, Takahashi R
    • Journal Title

      NeuroReport

      Volume: 21 Pages: 1121-1125

    • DOI

      10.1097/wnr.0b013e328340a731

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21500336, KAKENHI-PROJECT-22590930

  • [Journal Article] A mouse model characterizing features of vascular dementia with hippocampal atrophy2010
    • Author(s)
      Nishio K, Ihara M, Yamasaki N, KalariaRN, Maki T, Fujita Y, Ito H, Oishi N, Fukuyama H, Miyakawa T, Takahashi R, Tomimoto H
    • Journal Title

      Stroke

      Volume: 41 Pages: 1278-1284

    • DOI

      10.1161/strokeaha.110.581686

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21500336

  • [Journal Article] Nonhypotensive Dose of Telmisartan Attenuates Cognitive Impariment Partially due to Peroxisome Proliferator-Activated Receptor-γ Activation in Mice with Chronic Cerebral Hypoperfusion.2010
    • Author(s)
      Washida K, Ihara M, Nishio K, Fujita Y, Maki T, Yamada M, Takahashi J, Wu X, Kihara T, Ito H, Tomimoto H, Takahashi R.
    • Journal Title

      Stroke. 2010 41

      Pages: 1798-1806

    • Data Source
      KAKENHI-PROJECT-20390383

  • [Journal Article] Ammonium chloride and tunicamycin are novel toxins for dopaminergic neurons and induced Parkinson's disease-like phenotypes in medaka fish.2010
    • Author(s)
      Matsui H, Ito H, Taniguchi Y, Takeda S, Takahashi R.
    • Journal Title

      J Neurochem. 115

      Pages: 1150-1160

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390244

  • [Journal Article] Early protective effect of bone marrow mononuclear cells against ischemic white matter damage through augmentation of cerebral blood flow2010
    • Author(s)
      Fujita Y, Ihara M, Ushiki T, Hirai H, Kizaka-kondoh S, Hiraoka M, Ito H, Takahashi R
    • Journal Title

      Stroke

      Volume: 41 Pages: 2938-2943

    • DOI

      10.1161/strokeaha.110.596379

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21500336

  • [Journal Article] Nonhypotensive dose of telmisartan attenuates cognitive impairment partially due to PPAR-γactivation in mice with chronic cerebral hypoperfusion2010
    • Author(s)
      Washida K, Ihara M, Nishio K, Fujita Y, Takahashi J, Wu X, Kihara T, Ito H, Tomimoto H, Takahashi R
    • Journal Title

      Stroke

      Volume: 41 Pages: 1798-1806

    • DOI

      10.1161/strokeaha.110.583948

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21500336

  • [Journal Article] The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila.2010
    • Author(s)
      Imai Y, Kanao T, SawadaT, Kobayashi Y, Moriwaki Y, Ishida Y, Takeda K, Ichijo H, Lu B, Takahashi R.
    • Journal Title

      Plos Genetics. Epub Dec2;6(12)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390244

  • [Journal Article] HtrA2/Omi-immunoreactive intraneuronal inclusions in the anterior horn from patients with sporadic and SOD1 mutant amyotrophic lateral sclerosis.2010
    • Author(s)
      Kawamoto Y, Ito H, Kobayashi Y, Suzuki Y, Ihara M, Kawamata J, Akiguchi I, Fujimura H, Sakoda S, Kusaka H, Hirano A, Takahashi R
    • Journal Title

      Neuropath. Appl.Neurobiol. 36

      Pages: 331-344

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390244

  • [Journal Article] Nonhypotensive dose of Telmisartan attenuates cognitive impairment partially due to peroxisome proliferator-activated receptor-γ activation in mice with chronic cerebral hypoperfusion.2010
    • Author(s)
      Washida K, Ihara M, Nishio K, Fujita Y, Maki T, Yamada M, Takahashi J, Wu X, Kihara T, Ito H, Tomimoto H, Takahashi R.
    • Journal Title

      Stroke

      Volume: 41 Pages: 1798-1806

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390383

  • [Journal Article] Ammonium chloride and tunicamycin are novel toxins for dopaminergic neurons and induce Parkinson's disease-like phenotypes in medaka fish2010
    • Author(s)
      Matsui H, Ito H, Taniguchi Y, Takeda S, Takahashi R
    • Journal Title

      Journal of Neurochemistry

      Volume: 115 Pages: 1150-1160

    • DOI

      10.1111/j.1471-4159.2010.07012.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21500336

  • [Journal Article] Matrigel supports survival and neuronal differentiation of grafted embryonic stem cell-derived neural precursor cells2010
    • Author(s)
      Uemura M, Refaat M.M, Shinoyama M, Hayashi H, Hashimoto N, Takahashi J.
    • Journal Title

      J Neurosci Res 88

      Pages: 542-551

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390383

  • [Journal Article] Protein disulfide 1somerase-immunopositive inclusions in patients with Alzheimer disease2010
    • Author(s)
      Honjo Y, Ito H, Horibe T, Takahashi R, Kawakami K
    • Journal Title

      Brain Research

      Volume: 1349 Pages: 90-963

    • DOI

      10.1016/j.brainres.2010.06.016

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21500336

  • [Journal Article] Abnormal auditory cortex with giant N100m signal in patients with autosomal dominant lateral temporal lobe epilepsy.2009
    • Author(s)
      Usui K, Ikeda A, Nagamine T, Matsubayashi J, Matsumoto R, Hiraumi H, Kawamata J, Matsuhashi M, Takahashi R, Fukuyama H.
    • Journal Title

      Clin Neurophysiol. 120

      Pages: 1923-1926

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390244

  • [Journal Article] Selective nuclear shrinkage of oligodendrocytes lacking glial cytoplasmic inclusions in multiple system atrophy : a3-dimensional volumetric study.2009
    • Author(s)
      Uyama N, Uchihara T, Mochizuki Y, Nakamura A, Takahashi R, Mizutani T.
    • Journal Title

      J Neuropathol Exp Neurol. 68

      Pages: 1084-1091

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390244

  • [Journal Article] 筋萎縮性側索硬化症(ALS)の治療戦略2009
    • Author(s)
      村上学, 井上治久, 高橋良輔
    • Journal Title

      ファルマシア

      Volume: 45 Pages: 1009-1112

    • Data Source
      KAKENHI-PROJECT-21591079

  • [Journal Article] Nicotinic receptor stimulation protects nigral dopaminergic neurons in rotenone-induced Parkinson's disease models.2009
    • Author(s)
      Takeuchi H, Yanagida T, Inden M, Takata K, Kitamura Y, Yamakawa K, Sawada H, Izumi Y, Yamamoto N, Kihara T, Uemura K, Inoue H, Taniguchi T, Akaike A, Takahashi R, Shimohama S
    • Journal Title

      J Neurosci Res. 87

      Pages: 576-585

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390244

  • [Journal Article] Leukoencephalopathy with cognitive impairment following tocilizumab for the treatment of rheumatoid arthritis (RA).2009
    • Author(s)
      Kobayashi K, Okamoto Y, Inoue H, Usui T, Ihara M, Kawamata J, Miki Y, Mimori T, Tomimoto H, Takahashi R
    • Journal Title

      Intern Med. 48

      Pages: 1307-1309

    • NAID

      130000121960

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390244

  • [Journal Article] Autoimmune autonomic ganglionopathy with Sjogren's syndrome : significance of ganglionic acetylcholine receptor antibody and th erapeutic approach.2009
    • Author(s)
      Kondo T, Inoue H, Usui T, Mimori T, Tomimoto H, Vernino S, Takahashi R
    • Journal Title

      Auton Neurosci. 146

      Pages: 33-35

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390244

  • [Journal Article] Edaravone in ALS. (commentary)2009
    • Author(s)
      Takahashi R
    • Journal Title

      Exp Neurol. 217

      Pages: 235-236

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390244

  • [Journal Article] Negative motor seizure arising from the negative motor area : is it ictal apraxia?2009
    • Author(s)
      Ikeda A, Hirasawa K, Kinoshita M, Hitomi T, Matsumoto R, Mitsueda T, Taki JY, Inouch M, Mikuni N, Hori T, Fukuyama H, Hashimoto N, Shibasaki H, Takahashi R
    • Journal Title

      Epilepsia. 50

      Pages: 2072-2084

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390244

  • [Journal Article] N-cadherin-based adhesion enhances Abeta release and decreases Abeta42/40 ratio.2009
    • Author(s)
      Uemura K, Lill CM, Banks M, Asada M, Aoyagi N, Ando K, Kubota M, Kihara T, Nishimoto T, Sugimoto H, Takahashi R, Hyman BT, Shimohama S, Berezovska O, Kinoshita A.
    • Journal Title

      J.Neurochem. 108

      Pages: 350-360

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390244

  • [Journal Article] Cortical microinfarcts in Alzheimer's disease and subcortical vascular dementia.2009
    • Author(s)
      Okamoto Y, Ihara M, Fujita Y, Ito H, Takahashi R, Tomimoto H
    • Journal Title

      Neuroreport. 20

      Pages: 990-996

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390244

  • [Journal Article] Mutations in LGI1 gene in Japanese families with autosomal dominant lateral temporal lobe epilepsy : The first report from Asian families.2009
    • Author(s)
      Kawamata J, Ikeda A, Fujita Y, Usui K, Shimohama S, Takahashi R
    • Journal Title

      Epilepsia. Sep22.[Epub ahead of print]

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390244

  • [Journal Article] Chronic cerebral hypoperfusion accelerates amyloid beta deposition in APPSwInd transgenic mice.2009
    • Author(s)
      Kitaguchi H, Tomimoto H, Ihara M, Shibata M, Uemura K, Kalaria RN, Kihara T, Asada-Utsugi M, Kinoshita A, Takahashi R
    • Journal Title

      Brain Res. 1294

      Pages: 202-210

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390244

  • [Journal Article] Cortical microinfarcts in Alzheimer's disease and subcortical vascular dementia2009
    • Author(s)
      Okamoto Y, Ihara M, Fujita Y, Ito H, Takahashi R, Tomimoto H
    • Journal Title

      Neuroreport

      Volume: 20 Pages: 990-996

    • DOI

      10.1097/wnr.0b013e32832d2e6a

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21500336

  • [Journal Article] Dopamine facilitates alpha-synuclein oligomerization in human neuroblastoma SH-SY5Y cells.2009
    • Author(s)
      Yamakawa K, Izumi Y, Takeuchi H, Yamamoto N, Kume T, Akaike A, Takahashi R, Shimohama S, Sawada H.
    • Journal Title

      Biochem Biophys Res Commun. Nov11 [Epub ahead of print]

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390244

  • [Journal Article] Diagnostic accuracy of cardiac metaiodobenzylguanidine scintigraphy in Parkinson disease.2009
    • Author(s)
      Sawada H, Oeda T, Yamamoto K, Kitagawa N, Mizuta E, Hosokawa R, Ohba M, Nishio R, Yamakawa K, Takeuchi H, Shimohama S, Takahashi R, Kawamura T
    • Journal Title

      Eur J Neurol. 16

      Pages: 174-182

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390244

  • [Journal Article] 筋萎縮性側索硬化症(ALS)の治療戦略2009
    • Author(s)
      村上学、井上治久、高橋良輔
    • Journal Title

      ファルマシア 45

    • Data Source
      KAKENHI-PROJECT-21591079

  • [Journal Article] Attenuation of proteolysis-mediated cyclin E regulation by alternatively spliced Parkin in human colorectal cancers.2009
    • Author(s)
      Ikeuchi K, Marusawa H, Fujiwara M, Matsumoto Y, Endo Y, Watanabe T, Iwai A, Sakai Y, Takahashi R, Chiba T
    • Journal Title

      Int J Cancer. 125

      Pages: 2029-2035

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390244

  • [Journal Article] A chemical neurotoxin, MPTP induces Parkinson's disease like phenotype, movement disorders and persistent loss of dopamine neurons in medaka fish.2009
    • Author(s)
      Matsui H, Taniguchi Y, Inoue H, Uemura K, Takeda S, Takahashi R
    • Journal Title

      Neurosci Res. 65

      Pages: 263-271

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390244

  • [Journal Article] L347P PINK1 mutant that fails to bind to Hsp90/cdc37 chaperones is rapidlydegraded in a proteasome-dependant manner.2008
    • Author(s)
      Moriwaki Y, KimY J, Ido Y, Misawa H, Kawashima K, Endo S, Takahashi, R.z
    • Journal Title

      Neurosci. Res. 61

      Pages: 43-48

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390244

  • [Journal Article] Accumulation of HtrA2/Omi in neuronal and glial inclusions in brains withalphasynucleinopathies.2008
    • Author(s)
      Kawamoto Y, Kobayashi Y, Suzuki Y, Inoue H, Tomimoto H, Akiguchi I, Budka H, Martins LM, Downward J, Takahashi R
    • Journal Title

      J.Neuropathol Exp Neurol. 67

      Pages: 984-993

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390244

  • [Journal Article] Meningeal cells induce dopaminergic neurons from embryonic stem cells.2008
    • Author(s)
      Hayashi H, Morizane A, Koyanagi M, Ono Y, Sasai Y, Hashimoto N, Takahashi J.
    • Journal Title

      Eur J Neurosci 27

      Pages: 261-268

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390383

  • [Journal Article] Cleveland DW Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis.2008
    • Author(s)
      Yamanaka K, Chun SJ, Boillee S, Fujimori-Tonou N, Yamashita H, Gutmann DH, Takahashi R, Misawa H
    • Journal Title

      Nat.Neurosci. 11

      Pages: 251-253

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390244

  • [Journal Article] Rines/RNF180, a novel RING finger gene-encoded product, is a membrane-bound ubiquitin ligase.2008
    • Author(s)
      Ogawa M, Mizuguchi K, Ishiguro A, Koyabu Y, Imai Y, Takahashi R, Mikoshina K, Aruga J
    • Journal Title

      Gene Cells 13

      Pages: 397-409

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390244

  • [Journal Article] Parkin as a tumor suppressor gene for hepatocellular carcinoma.2008
    • Author(s)
      Fujiwara M, Marusawa, H, Wang HQ, Iwai A, Ikeuchi K, Imai Y, Kataoka A, Nukina N, Takahashi R, Chiba T
    • Journal Title

      Oncogene. 27

      Pages: 6002-6011

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390244

  • [Journal Article] Inhibition of the Rho/ROCK pathway reduces apoptosis during transplantation of embryonic stem cell-derived neural precursors.2008
    • Author(s)
      Koyanagi M, Takahashi J, Arakawa Y, Doi D, Fukuda H, Hayashi. H, Narumiya S, Hashimoto N.
    • Journal Title

      J Neurosci Res 86(2)

      Pages: 270-280

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390383

  • [Journal Article] Pael-R transgenic mice crossed with parkin deficient mice displayed progressive and selective catecholaminergic neuronal loss.2008
    • Author(s)
      Wang HQ, Imai Y, Inoue H, Kataoka A, Iita S, Nukina N, Takahashi R
    • Journal Title

      J.Neurochem. 107

      Pages: 171-185

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390244

  • [Journal Article] Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila.2008
    • Author(s)
      Imai Y, Gehrke S, Wang HQ, Takahashi R, Hasegawa K, Oota E, Lu B
    • Journal Title

      EMBO J. 27

      Pages: 2432-2443

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390244

  • [Journal Article] Immune or inflammatory response by the host brain suppresses neuronal differentiation of transplanted ES cell-derived neural precursor cells.2008
    • Author(s)
      Ideguchi M, Shinoyama M, Gomi M, Hayashi H, Hashimoto N, Takahashi J.
    • Journal Title

      J Neurosci Res 86(9)

      Pages: 1936-1943

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390383

  • [Journal Article] SOD1 aggregates generated within motoneuronal dendrites/cell bodies move into axons before disease onset in a G93ASOD1 transgenic mouse model.2006
    • Author(s)
      Ryosuke Takahashi
    • Journal Title

      The 17^<th> International symposium on ALS/MND

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590907

  • [Journal Article] Quantitative evaluation of the pyramidal tract segmented by diffusion tensor tractography : feasibility study in patients with ainyotrophic lateral sclerosis.2005
    • Author(s)
      Aoki S, Iwata NK, Masutani Y. Yoshida M, Abe 0, Ugawa Y, Masumoto T, Mori H, Hayashi N, Kabasawa H, Kwak S, Takahashi S, Tsuji S, Ohtomo K
    • Journal Title

      Radiat Med 23

      Pages: 195-9

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390251

  • [Journal Article] Unsaturated fatty acids induce cytotoxic aggregate formation of amyotrophic lateral sclerosis-linked superoxide dismutase 1 mutants.2005
    • Author(s)
      Kim YJ, Nakatomi R, Akagi T, Hashikawa T, Takahashi R.
    • Journal Title

      J.Biol.Chem. in press

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14207032

  • [Journal Article] Quantitative evaluation of the pyramidal tract segmented by diffusion tensor tractography : feasibility study in patients with amyotrophic lateral sclerosis2005
    • Author(s)
      Aoki S, Iwata NK, Masutani Y, Yoshida M, Abe O, Ugawa Y, Masumoto T, Mori H, Hayashi N, Kabasawa H, Kwak S, Takahashi S, Tsuji S, Ohtomo K
    • Journal Title

      Radiat Med 23

      Pages: 195-199

    • Data Source
      KAKENHI-PROJECT-17390251

  • [Journal Article] Quantitative evaluation of the pyramidal tract segmented by diffusion tensor tractography: feasibility study in patients with amyotrophic lateral sclerosis.2005
    • Author(s)
      Aoki S, Iwata NK, Masutani Y, Yoshida M, Abe 0, Ugawa Y, Masumoto T, Mori H, Hayashi N, Kabasawa H, Kwak S, Takahashi S, Tsuji S, Ohtomo K
    • Journal Title

      Radiat Med 23

      Pages: 195-9

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390251

  • [Journal Article] Calcium-permeable AMPA receptors promote misfolding of mutant S0D1 protein and development of amyotrophic lateral sclerosis in a transgenis mouse model.2004
    • Author(s)
      Tateno, M., Sadakata, H., Tanaka, M., Itohara, S., Shin, R-M., Miula, M., Masuda, M., Aosaki, T., Urushitani, M., Misawa, H., Takahashi, R.
    • Journal Title

      Hum.Mol.Genet. 13

      Pages: 2183-2196

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14207032

  • [Journal Article] caspase-9とALS2004
    • Author(s)
      井上治久, 高橋良輔
    • Journal Title

      臨床検査 48

      Pages: 1577-1580

    • Data Source
      KAKENHI-PROJECT-16015330

  • [Journal Article] How do Parkin mutation result in neurodegeneration?2004
    • Author(s)
      Imai, Y., Takahashi, R.
    • Journal Title

      Curr.Opin.Neurobiol. 14

      Pages: 384-389

    • Data Source
      KAKENHI-PROJECT-14207032

  • [Journal Article] Parkin and ER stress.2003
    • Author(s)
      Takahashi, R., Imai, Y., Hattori, N., Mizuno, Y
    • Journal Title

      Ann.N.Y.Acad.Sci. 991

      Pages: 101-106

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14207032

  • [Journal Article] Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila.2003
    • Author(s)
      Yang, Y., Nishimura, I., Imai, Y., Takahashi, R., Lu, B.
    • Journal Title

      Neuron 37

      Pages: 911-924

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14207032

  • [Journal Article] Parkin and ER stress.2003
    • Author(s)
      Takahashi, R
    • Journal Title

      Ann.N.Y.Acad.Sci. 991

      Pages: 101-106

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14207032

  • [Journal Article] The crucial role of caspase-9 in the disease progression of transgenic ALS mouse model.2003
    • Author(s)
      Inoue, H., Tsukita, K., Iwasato, T., Suzuki, Y., Tomioka, M, Tateno, M, Nagao, M, Kawata, A., Saido, T.C., Miura, M., Misawa, H., Itohara, S., Takahashi, R.
    • Journal Title

      EMBO J. 22

      Pages: 6665-6674

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14207032

  • [Journal Article] CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity.2002
    • Author(s)
      Imai, Y., Soda, M., Hatakeyama, S., Akagi, T., Hashikawa, T., Nakayama, K-I., Takahashi.R
    • Journal Title

      Mol.Cell 10

      Pages: 55-67

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14207032

  • [Journal Article] XIAP immunoreactivity in glial and neuronal cytoplasmic inclusions in multiple system atrophy
    • Author(s)
      Kawamoto Y, Ito H, Ihara M, Takahashi R
    • Journal Title

      Clinical Neuropathology

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590930

  • [Journal Article] Chemical library screening identifies a small molecule that downregulates SOD1 transcription for drugs to treat ALS
    • Author(s)
      Murakami, G., Inoue, H., Tsukita, K., Asai, Y., Amagai, Y., Aiba, K., Shimogawa, H., Uesugi, M., Nakatsuji, N., Takahashi, R.
    • Journal Title

      The Journal of Biomolecular Screening

      Volume: (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591079

  • [Presentation] GBA2 a new modifier for Gauchers’s disease and GBA1-related Parkinson’s disease?2018
    • Author(s)
      Etsuro Nakanishi, Norihito Uemura, Hisako Akiyama, Masato Kinoshita, Hodaka Yamakado, Shunichi Takeda, Yoshio Hirabayashi, Ryosuke Takahashi
    • Organizer
      AOCN2018, Seoul
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-17H05698

  • [Presentation] α-synuclein propagation in brains via olfactory pathway in non-human primate model.2018
    • Author(s)
      澤村 正典, 尾上浩隆, 上村紀仁, 伊佐正, 高橋良輔
    • Organizer
      MDS2018, Hongkong
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-17H05698

  • [Presentation] GBA haploinsufficiency accelerated alpha synuclein pathology with altered lipid metabolism in a premotor model of Parkinson’s disease2018
    • Author(s)
      H. Yamakado, M. Ikuno, H. Akiyama, L. Parajuli, K. Taguchi, J. Hara, N. Uemura, Y. Hatanaka, K. Higaki, M. Tanaka, M. Koike, Y. Hirabayashi, R. Takahashi
    • Organizer
      MDS2018, Hongkong
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-17H05698

  • [Presentation] Deletion of GBA2 in neuronopathic Gaucher's disease medaka couldn’t rescue the phenotype.2018
    • Author(s)
      Etsuro Nakanishi, Norihito Uemura, Hisako Akiyama, Masato Kinoshita, Hodaka Yamakado, Shunichi Takeda, Yoshio Hirabayashi, Ryosuke Takahashi
    • Organizer
      MDS2018, Hongkong
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-17H05698

  • [Presentation] αシヌクレイントランスジェニックマウスへのフィブリル脳内接種によるパーキンソン病モデル作製2017
    • Author(s)
      奥田真也、上村紀仁、上村麻衣子、山門穂高、高橋良輔
    • Organizer
      第11回パーキンソン病・運動障害疾患コングレス
    • Data Source
      KAKENHI-PROJECT-16K19509

  • [Presentation] Is the GBA2 a new modifier for Gauchers’s disease and GBA1-related Parkinson’s disease?2017
    • Author(s)
      Etsuro Nakanishi, Norihito Uemura, Satoko Akiyama, Masato Kinoshita, Hodaka Yamakado, Shun-ichi Takeda, Yoshio Hirabayashi, Ryosuke Takahashi
    • Organizer
      MDS2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02540

  • [Presentation] Inoculation of alpha-synuclein fibrils into the mouse gastrointestinal tract induces Lewy-like pathology in the brain via the vagal nerve2017
    • Author(s)
      Norihito Uemura, Maiko T Uemura, Hisashi Yagi, Ryosuke Takahashi
    • Organizer
      WCN2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-17H05698

  • [Presentation] A novel mice model for Parkinson's disease: fibril-inoculated mutant α-synuclein BAC transgenic mice2017
    • Author(s)
      奥田真也、上村紀仁、上村麻衣子、山門穂高、高橋良輔
    • Organizer
      World congress of Neurology
    • Data Source
      KAKENHI-PROJECT-16K19509

  • [Presentation] ΑLPHA-SYNUCLEIN-INDUCED PATHOLOGY OF OLIGODENDROCYTES AND MULTIPLE SYSTEM ATROPHY2017
    • Author(s)
      Seiji Kaji, Takakuni Maki, Norihito Uemura, Ryosuke Takahashi
    • Organizer
      The 2nd International Taiwanese Congress of Neurology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-17H05698

  • [Presentation] Creating mouse models for sporadic Parkinson's disease based on its genetic risk factors2017
    • Author(s)
      Masashi Ikuno, Hodaka Yamakado, Ryosuke Takahashi
    • Organizer
      WCN2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02540

  • [Presentation] ELUCIDATING ALPHA-SYNUCLEIN PATHOLOGY OF MULTIPLE SYSTEM ATROPHY USING PRIMARY OLIGODENDROCYTE CULTURE2017
    • Author(s)
      Seiji Kaji, Takakuni Maki, Norihito Uemura, Ryosuke Takahashi
    • Organizer
      WCN2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-17H05698

  • [Presentation] Validation of the Questionnaire for impulsive-compulsive disorders in Parkinson’s disease-rating scale (QUIP-RS) in Japanese.2017
    • Author(s)
      Takahashi M, Ito H, et al
    • Organizer
      XXIII World Congress of Neurology 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04270

  • [Presentation] Lewy pathology is accelerated in α-Synuclein fibril inoculated α-Synuclein BAC transgenic mice2017
    • Author(s)
      奥田 真也、上村紀仁、山門穂高、高橋良輔
    • Organizer
      第40回神経科学学会
    • Data Source
      KAKENHI-PUBLICLY-17H05698

  • [Presentation] Pathological role of GBA2 in GBA1-deficient neuronopathic Gaucher’s disease model of medaka2017
    • Author(s)
      Etsuro Nakanishi, Norihito Uemura, Satoko Akiyama, Masato Kinoshita, Hodaka Yamakado, Shun-ichi Takeda, Yoshio Hirabayashi, Ryosuke Takahashi
    • Organizer
      WCN2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02540

  • [Presentation] A NOVEL MICE MODEL FOR PARKINSON’S DISEASE: FIBRIL-INOCULATED MUTANT α-SYNUCLEIN BAC TRANSGENIC MICE2017
    • Author(s)
      Shinya Okuda, Norihito Uemura, Maiko T Uemura, Hodaka Yamakado, Ryosuke Takahashi
    • Organizer
      WCN2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-17H05698

  • [Presentation] α-Synuclein Preformed Fibrils Induce Disruption of Myelin Basic Protein Expression in Primary Oligodendrocyte Culture Deciphering Glial Pathology in Multiple System Atrophy2017
    • Author(s)
      Seiji Kaji, Takakuni Maki, Norihito Uemura, Ryosuke Takahashi
    • Organizer
      International Congress of Parkinson’s Disease and Movement Disorders
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-17H05698

  • [Presentation] Inoculation of alpha-synuclein fibrils into the mouse gastrointestinal tract induces Lewy-like pathology in the brain via the vagal nerve2017
    • Author(s)
      上村紀仁、上村麻衣子、八木寿梓、高橋良輔
    • Organizer
      World congress of Neurology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K19509

  • [Presentation] αシヌクレイントランスジェニックマウスへのフィブリル脳内接種によるパーキンソン病モデル作製2017
    • Author(s)
      奥田 真也、上村紀仁、上村麻衣子、山門穂高、高橋良輔
    • Organizer
      第11回パーキンソン病・運動障害疾患コングレス
    • Data Source
      KAKENHI-PUBLICLY-17H05698

  • [Presentation] The Possible Pathological Interaction Between Oligodendrocyte Precursor Cells and Multiple System Atrophy2017
    • Author(s)
      梶 誠兒、眞木崇州、上村紀仁、高橋良輔
    • Organizer
      第40回神経科学学会
    • Data Source
      KAKENHI-PUBLICLY-17H05698

  • [Presentation] 遺伝的リスクファクターを用いた孤発性パーキンソン病モデルマウスの作成2017
    • Author(s)
      生野 真嗣、山門穂高、高橋良輔
    • Organizer
      第40回神経科学学会
    • Data Source
      KAKENHI-PROJECT-15H02540

  • [Presentation] Pathological role of GBA2 in GBA1-deficient neuronopathic Gaucher’s disease model of medaka2017
    • Author(s)
      中西悦郎、上村紀仁、秋山央子、木下政人、山門穂高、武田俊一、平林義雄、高橋良輔
    • Organizer
      第40回神経科学学会
    • Data Source
      KAKENHI-PROJECT-15H02540

  • [Presentation] Does inoculation of α-synuclein fibrils promote Lewy-pathology of α-synuclein BAC transgenic mice?2016
    • Author(s)
      奥田真也、上村紀仁、生野真嗣、山門穂高、高橋良輔
    • Organizer
      第10回パーキンソン病・運動障害疾患コングレス
    • Place of Presentation
      京都
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-16K19509

  • [Presentation] Viable neuronopathic Gaucher disease model in medaka (Oryzias latipes) displays axonal accumulation of alpha-synuclein2016
    • Author(s)
      Norihito Uemura, Ryosuke Takahashi
    • Organizer
      International Meeting on Aquatic Model Organisms for Human Disease and Toxicology Research
    • Place of Presentation
      名古屋
    • Year and Date
      2016-03-18
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02540

  • [Presentation] ドーパミン欠乏がもたらす記憶成立過程依存的な運動学習障害2016
    • Author(s)
      畑中悠佑，高橋良輔
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-07-20
    • Data Source
      KAKENHI-PROJECT-16K19508

  • [Presentation] Does endogenic alpha-synuclein have protective property in human alpha-synuclein transgenic models?2016
    • Author(s)
      Masanori Sawamura, Norihito Uemura, Ryosuke Takahashi
    • Organizer
      5th Asian and Oceanian Parkinson's Disease and Movement Disorders Congress
    • Place of Presentation
      マニラ
    • Year and Date
      2016-03-13
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02540

  • [Presentation] ドーパミン欠乏がもたらす記憶成立過程依存的な運動学習障害2016
    • Author(s)
      畑中悠佑，高橋良輔
    • Organizer
      第10回 パーキンソン病・運動障害疾患コングレス
    • Place of Presentation
      京都ホテルオークラ
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-16K19508

  • [Presentation] Pathological role of GBA2 in GBA1-deficient neuronopathic Gaucher’s disease model of medaka2016
    • Author(s)
      E Nakanishi, N Uemura, H Akiyama, M Kinoshita, H Yamakado, T Shunichi, Y Hirabayashi, R Takahashi
    • Organizer
      第39回神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-20
    • Data Source
      KAKENHI-PROJECT-15H02540

  • [Presentation] Fish model of Parkinson’s disease.2016
    • Author(s)
      Takahashi R
    • Organizer
      Keio Longevity Seminar Series “Resilience in Brain Agin &#8211;From Model Systems of Neurodegenerastion to Supercentenarian Study” Keio Longevity Initiative Seminar Series,
    • Place of Presentation
      東京
    • Year and Date
      2016-02-18
    • Invited
    • Data Source
      KAKENHI-PLANNED-23111002

  • [Presentation] 神経型ゴーシェ病モデルメダカの中枢神経におけるGBA2の役割2016
    • Author(s)
      中西 悦郎、上村紀仁、秋山央子、木下政人、山門穂高、武田俊一、平林義雄、高橋良輔
    • Organizer
      第10回パーキンソン病・運動障害疾患コングレス
    • Place of Presentation
      京都
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-15H02540

  • [Presentation] Pathological studies in Parkinson's disease2016
    • Author(s)
      Seiji Kaji, Norihito Uemura, Takakuni Maki, Makoto Urushitani, Ryosuke Takahash
    • Organizer
      Symposium for Young Neurologists and Emerging Researchers Grooming for Interaction and Excellence in Science (SYNERGIES)
    • Place of Presentation
      マニラ
    • Year and Date
      2016-03-10
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02540

  • [Presentation] Pathological studies in Parkinson's disease2016
    • Author(s)
      Seiji Kaji, Norihito Uemura, Takakuni Maki, Makoto Urushitani, Ryosuke Takahashi
    • Organizer
      Symposium for Young Neurologists and Emerging Researchers Grooming for Interaction and Excellence in Science (SYNERGIES)
    • Place of Presentation
      Manila
    • Year and Date
      2016-03-10
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26670442

  • [Presentation] Viable neuronopathic Gaucher disease model in medaka (Oryzias latipes) displays axonal accumulation of alpha-synuclein2016
    • Author(s)
      Norihito Uemura, Ryosuke Takahashi
    • Organizer
      International Meeting on Aquatic Model Organisms for Human Disease and Toxicology Research
    • Place of Presentation
      Nagoya
    • Year and Date
      2016-03-18
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26670442

  • [Presentation] Inoculation of α-synuclein fibrils to α-synuclein BAC transgenic mice did not accelerate Lewy-like pathology2016
    • Author(s)
      奥田真也、上村紀仁、高橋良輔
    • Organizer
      第39回神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-20
    • Data Source
      KAKENHI-PROJECT-16K19509

  • [Presentation] Does endogenic alpha-synuclein have protective property in human alpha-synuclein transgenic models?2016
    • Author(s)
      Masanori Sawamura, Norihito Uemura, Ryosuke Takahashi
    • Organizer
      5th Asian and Oceanian Parkinson's Disease and Movement Disorders Congress
    • Place of Presentation
      Manila
    • Year and Date
      2016-03-13
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26670442

  • [Presentation] Takahashi R2016
    • Author(s)
      Takahashi R
    • Organizer
      Keio Longevity Seminar Series “Resilience in Brain Agin &#8211;From Model Systems of Neurodegenerastion to Supercentenarian Study” Keio Longevity Initiative Seminar Series,
    • Place of Presentation
      東京
    • Year and Date
      2016-02-18
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] Pathological role of GBA2 in GBA1-deficient neuronopathic Gaucher’s disease model of medaka2016
    • Author(s)
      E Nakanishi, N Uemura, H Akiyama, M Kinoshita, H Yamakado, T Shunichi, Y Hirabayashi, R Takahashi
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸
    • Year and Date
      2016-05-21
    • Data Source
      KAKENHI-PROJECT-15H02540

  • [Presentation] Medaka fish model of Parkinson’s disease2015
    • Author(s)
      Norihito Uemura, Ryosuke Takahashi
    • Organizer
      10th GEO-PD
    • Place of Presentation
      東京
    • Year and Date
      2015-10-02
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02540

  • [Presentation] Modeling Parkinson’s Diease in Animals and iPS cells.2015
    • Author(s)
      Takahashi R,
    • Organizer
      2nd Taiwan international Congress of Parkinson’s Diease and Movement Disorders
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2015-03-28
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] Parkinson Disease Treatment: Current Perspective and Future Directions.(Plenary Lecture)2015
    • Author(s)
      Takahashi R
    • Organizer
      ASEAN 2015 Neuroscience
    • Place of Presentation
      Singapore
    • Year and Date
      2015-07-30
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] Current Perspectives and Future Directions2015
    • Author(s)
      Ryosuke Takahashi
    • Organizer
      ASEANNeuroscience 2015
    • Place of Presentation
      シンガポール
    • Year and Date
      2015-07-31
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02540

  • [Presentation] The Mechanism of Motor Neuron Degeneration in Ubiquitin Proteasome System Dysfunction2015
    • Author(s)
      星野　友則、Yamashita H, Tashiro Y, Misawa H, Makoto U, Takahashi R
    • Organizer
      BMB2015
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-02
    • Data Source
      KAKENHI-PLANNED-23111002

  • [Presentation] Pathological role of GBA2 in GBA1-deficient neuronopathic Gaucher’s disease model of medaka2015
    • Author(s)
      中西　悦郎、上村紀仁、秋山央子、木下政人、山門穂高、武田俊一、平林義雄、高橋良輔
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-30
    • Data Source
      KAKENHI-PROJECT-26670442

  • [Presentation] Hereditary Diffuse Leukoencephalopathy with Spheroids: A Hidden Culprit.2015
    • Author(s)
      梶　誠兒、沖亮祐、宮本亮介、瓦井俊孝、和泉唯信、梶龍兒、高橋良輔
    • Organizer
      第56回日本神経学会　学術集会
    • Place of Presentation
      新潟
    • Year and Date
      2015-05-21
    • Data Source
      KAKENHI-PLANNED-23111002

  • [Presentation] Pathological role of GBA2 in GBA1-deficient neuronopathic Gaucher’s disease model of medaka2015
    • Author(s)
      中西悦郎、上村紀仁、秋山央子、木下政人、山門穂高、武田俊一、平林義雄、高橋良輔
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-30
    • Data Source
      KAKENHI-PROJECT-15H02540

  • [Presentation] Parkinson Disease Treatment: Current Perspective and Future Directions.(Plenary Lecture)2015
    • Author(s)
      Takahashi R
    • Organizer
      ASEAN 2015 Neuroscience
    • Place of Presentation
      Singapore
    • Year and Date
      2015-07-30
    • Invited
    • Data Source
      KAKENHI-PLANNED-23111002

  • [Presentation] VHL とCUL2; TDP-43 の凝集を促進するVHL と分解を促進するCUL2. TDP-43 proteinopathy におけるVHL の2 面性.2015
    • Author(s)
      内田 司, 玉木良高, 小代明美, 綾木 孝, 守村敏史, 辰巳新水, 伊東秀文, 坂下 直実, 高橋良輔, 漆谷真.
    • Organizer
      第56回日本神経学会　学術集会
    • Place of Presentation
      新潟
    • Year and Date
      2015-05-22
    • Data Source
      KAKENHI-PLANNED-23111002

  • [Presentation] Pathological role of the innate immune system in neuronopathic Gaucher disease model in medaka2015
    • Author(s)
      Norihito Uemura, Etsuro Nakanishi, Masato Kinoshita, Hodaka Yamakado, Shunichi Takeda, Ryoruke Takahashi
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-30
    • Data Source
      KAKENHI-PROJECT-26670442

  • [Presentation] Pathological role of GBA2 in GBA1-deficient neuronopathic Gaucher’s disease model of medaka2015
    • Author(s)
      Yosuke Taruno, Hideaki Matsui, Norihito Uemura, Hodaka Yamakado, Ryoruke Takahashi
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-30
    • Data Source
      KAKENHI-PLANNED-23111002

  • [Presentation] Creating mice models for Parkinson's disease based on its genetic risk factors2015
    • Author(s)
      生野　真嗣、浅野剛史、山門穂高、高橋良輔
    • Organizer
      第56回日本神経学会　学術集会
    • Place of Presentation
      新潟
    • Year and Date
      2015-05-23
    • Data Source
      KAKENHI-PLANNED-23111002

  • [Presentation] 孤発性パーキンソン病の遺伝的リスク因子を利用した新しいパーキンソン病モデルマウス作製の試み2015
    • Author(s)
      生野真嗣、浅野剛史、山門穂高、高橋良輔
    • Organizer
      第9回パーキンソン病・運動障害疾患コングレス
    • Place of Presentation
      東京
    • Year and Date
      2015-10-16
    • Data Source
      KAKENHI-PLANNED-23111002

  • [Presentation] Analysis of the ATP13A2mutant (PARK9) medaka (Oryziaslatipes)2015
    • Author(s)
      Yosuke Taruno, Hideaki Matsui, Norihito Uemura, Hodaka Yamakado, Ryoruke Takahashi
    • Organizer
      第56回日本神経学会学術大会
    • Place of Presentation
      新潟
    • Year and Date
      2015-05-22
    • Data Source
      KAKENHI-PROJECT-26670442

  • [Presentation] Microarray analysis in Motor Neuron-Specific 26S Proteasome Conditional KO Mice2015
    • Author(s)
      星野　友則、Yamashita H, Tashiro Y, Misawa H, Takahashi R
    • Organizer
      第56回日本神経学会　学術集会
    • Place of Presentation
      新潟
    • Year and Date
      2015-05-21
    • Data Source
      KAKENHI-PLANNED-23111002

  • [Presentation] Current Perspectives and Future Directions2015
    • Author(s)
      Ryosuke Takahashi
    • Organizer
      ASEANNeuroscience 2015
    • Place of Presentation
      Singapore
    • Year and Date
      2015-07-31
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26670442

  • [Presentation] Medaka fish model of Parkinson’s disease2015
    • Author(s)
      Norihito Uemura, Ryosuke Takahashi
    • Organizer
      GEO-PD
    • Place of Presentation
      Tokyo
    • Year and Date
      2015-10-02
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26670442

  • [Presentation] Current Perspectives and Future Directions2015
    • Author(s)
      Ryosuke Takahashi
    • Organizer
      ASEANNeuroscience 2015
    • Place of Presentation
      シンガポール
    • Year and Date
      2015-07-31
    • Data Source
      KAKENHI-PLANNED-23111002

  • [Presentation] FUS遺伝子変異を伴う筋萎縮性側索硬化症の臨床像：若年発症例を含む4症例の検討.2015
    • Author(s)
      引網亮太,, 端祐一郎, 山門穂高,　辰己　新水,　山下博史,　澤本伸克,　辻輝之,　川本未知,　幸原伸夫,　井上治久,　漆谷真,　高橋良輔.
    • Organizer
      第56回日本神経学会　学術集会
    • Place of Presentation
      新潟
    • Year and Date
      2015-05-23
    • Data Source
      KAKENHI-PLANNED-23111002

  • [Presentation] Pathological role of the innate immune system in neuronopathic Gaucher disease model in medaka2015
    • Author(s)
      上村紀仁、中西悦郎、木下政人、山門穂高、武田俊一、高橋良輔
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-30
    • Data Source
      KAKENHI-PROJECT-15H02540

  • [Presentation] Medaka fish model of Parkinson’s disease2015
    • Author(s)
      Norihito Uemura, Ryosuke Takahashi
    • Organizer
      10th GEO-PD
    • Place of Presentation
      東京
    • Year and Date
      2015-10-02
    • Data Source
      KAKENHI-PLANNED-23111002

  • [Presentation] ApoE Isoforms Differentially Affect Amyloid beta-Induced Synaptic Toxicity2015
    • Author(s)
      上村　麻衣子、植村健吾、木下彩栄、高橋良輔
    • Organizer
      第56回日本神経学会　学術集会
    • Place of Presentation
      新潟
    • Year and Date
      2015-05-21
    • Data Source
      KAKENHI-PLANNED-23111002

  • [Presentation] 孤発性パーキンソン病の遺伝的リスク因子を利用した新しいパーキンソン病モデルマウス作製の試み2015
    • Author(s)
      生野真嗣、浅野剛史、山門穂高、高橋良輔
    • Organizer
      第9回パーキンソン病・運動障害疾患コングレス
    • Place of Presentation
      東京
    • Year and Date
      2015-10-16
    • Data Source
      KAKENHI-PROJECT-26670442

  • [Presentation] 孤発性パーキンソン病の遺伝的リスク因子を利用した新しいパーキンソン病モデルマウス作製の試み2015
    • Author(s)
      生野真嗣、浅野剛史、山門穂高、高橋良輔
    • Organizer
      第9回パーキンソン病・運動障害疾患コングレス
    • Place of Presentation
      東京
    • Year and Date
      2015-10-16
    • Data Source
      KAKENHI-PROJECT-15H02540

  • [Presentation] NF-κB経路を介したOptineurinのノックダウンによる神経細胞死2014
    • Author(s)
      秋月真由美、山下博文、植村健吾、丸山博文、川上秀史、伊東秀文、高橋良輔
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-09-12
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] マウスを用いたin vivoにおけるゾニサミドの作用機構2014
    • Author(s)
      浅野 剛史、山門 穂高、高橋 良輔
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      福岡市
    • Year and Date
      2014-05-24
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] ATP13A3 変異メダカの解析2014
    • Author(s)
      樽野陽亮、上村紀人、松井秀彰、山門穂高、高橋良輔
    • Organizer
      第37回日本神経科学学会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-09-13
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] 運動ニューロン特異的26Sプロテアソームノックアウトマウスの遺伝子網羅的解析2014
    • Author(s)
      星野 友則, 山下 博史, 田代 善崇, 三澤 日出巳, 高橋良輔
    • Organizer
      第55回日本神経病理学会総会学術研究会
    • Place of Presentation
      東京都
    • Year and Date
      2014-06-06
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] 血管性認知症におけるペリサイトとBMPに関する研究　（タイトル：BMP-4 expression by immature pericytes correlates with white matter damage.)2014
    • Author(s)
      上村麻衣子、猪原匡史、中込隆之、松山知弘、長束一行、木下彩栄、高橋良輔
    • Organizer
      第55回 日本神経学会学術大会
    • Place of Presentation
      福岡市
    • Year and Date
      2014-05-23
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] Bone morphogenic protein expression in pericytes is a pathological correlate of vascular cognitive impariment）2014
    • Author(s)
      上村麻衣子、猪原匡史、長束一行、木下彩栄、高橋良輔
    • Organizer
      International Stroke Conference 2014
    • Place of Presentation
      アメリカ、サンディエゴ
    • Year and Date
      2014-02-13
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] 孤発性パーキンソン病の遺伝的リスク因子を利用した新しいパーキンソン病モデルマウス作製の試み（ポスター）2014
    • Author(s)
      生野真嗣、浅野剛史、山門穂高、高橋良輔
    • Organizer
      第8回パーキンソン病・運動障害疾患コングレス
    • Place of Presentation
      京都市
    • Year and Date
      2014-10-03
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] 縦隔リンパ節の小細胞癌による抗Ma-2抗体陽性脳炎を呈した1剖検例2014
    • Author(s)
      綾木孝, 南山素三雄, 上田紗希帆, 濱谷美緒, 山門穂高, 竹内康英, 池本明人, 伊東秀文, 澤本伸克, 高橋良輔
    • Organizer
      第55回日本神経病理学会総会学術研究会
    • Place of Presentation
      学術総合センター　一橋講堂
    • Year and Date
      2014-06-07
    • Data Source
      KAKENHI-PROJECT-24300132

  • [Presentation] ATP13A4 変異メダカの解析2014
    • Author(s)
      樽野陽亮、上村紀人、松井秀彰、山門穂高、高橋良輔
    • Organizer
      小型魚類研究会
    • Place of Presentation
      東京都
    • Year and Date
      2014-09-20
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] Creating mice models for sporadic Parkinson’s disease based on its genetic risk factors（ポスター）2014
    • Author(s)
      生野真嗣、浅野剛史、山門穂高、高橋良輔
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-09-13
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] ALSのTDP-43のinclusion形成におけるVon Hippel-Lindau proteinの役割2014
    • Author(s)
      内田 司、小代 明美、守村 敏史、辰巳 新水、高橋 良輔、漆谷 真
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-09-11
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] Therapeutic approach to Parkinson’s disease by modifying α-synuclein transcription2014
    • Author(s)
      Yamakado H, Asano T, Takahashi R.
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      福岡市
    • Year and Date
      2014-05-24
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] Optineurin suppression causes neuronal cell death via NF-κB pathway2014
    • Author(s)
      Mayumi Akizuki, Hirofumi Yamashita, Kengo Uemura, Hirofumi Maruyama, Hideshi Kawakami, Hidefumi Ito, Ryosuke Takahashi
    • Organizer
      14th asian ＆ oceanian congress of Neurology
    • Place of Presentation
      マカオ
    • Data Source
      KAKENHI-PLANNED-23111002

  • [Presentation] GBA変異を有するパーキンソン病からの iPS 細胞の樹立2014
    • Author(s)
      陣上 直人,山門 穂高,小芝 泰,大江田 知子,澤田 秀幸,堀田 秋津,井上 治久,高橋 淳, 高橋 良輔
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-09-13
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] VHL, a modifier of degradation, aggregation and compartmentation of TDP-43 in ALS pathology.2014
    • Author(s)
      内田 司、小代 明美、玉木 良高、辰巳 新水、 守村 敏史、 高橋 良輔、 漆谷 真
    • Organizer
      第37回日本神経科学学会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-09-11
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] Alpha-synuclein accumulation in Gaucher disease model of medaka does not contribute to neurodegeneration2014
    • Author(s)
      Norihito Uemura, Tomoko Fujiwara-Ishikawa, Masato Kinoshita, Masato Koike, Hideaki Matsui, Hodaka Yamakado,Yasuo Uchiyama, Takeshi Todo, Shun-ichi Takeda and Ryosuke Takahashi
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-12
    • Data Source
      KAKENHI-PROJECT-26670442

  • [Presentation] ALSのTDP-43のinclusion形成におけるVon Hippel-Lindau proteinの役割2014
    • Author(s)
      内田 司，小代 明美，守村 敏史，辰巳 新水，高橋 良輔，漆谷 真
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-11
    • Data Source
      KAKENHI-PLANNED-23111002

  • [Presentation] αシヌクレイノパチーにおけるアポトーシス関連タンパク質の免疫組織化学的検討2014
    • Author(s)
      河本恭裕, 綾木孝, 漆谷真, 伊東秀文, 高橋良輔
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      福岡国際センター
    • Year and Date
      2014-05-23
    • Data Source
      KAKENHI-PROJECT-24300132

  • [Presentation] 血管性認知症におけるペリサイトとBMPに関する研究　（タイトル：BMP-4 expression by immature pericytes correlates with white matter damage.)2014
    • Author(s)
      上村麻衣子、猪原匡史、中込隆之、松山知弘、長束一行、木下彩栄、高橋良輔
    • Organizer
      第37回神経科学大会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-09-12
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] Optineurin suppression causes neuronal cell death via NF-κ B pathway2014
    • Author(s)
      Akizuki M, Yamashita H, Uemura K, Maruyama H, Kawakami H, Ito H, Takahashi R
    • Organizer
      14th Asian & Oceanian congress of Neurology
    • Place of Presentation
      マカオ
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Presentation] NF-κB経路を介したOptineurinのノックダウンによる神経細胞死2014
    • Author(s)
      秋月真由美, 山下博史, 植村健吾, 丸山博文, 川上秀史, 伊東秀文, 高橋良輔
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      福岡国際センター
    • Year and Date
      2014-05-21
    • Data Source
      KAKENHI-PROJECT-24300132

  • [Presentation] Alpha-synuclein accumulation in Gaucher disease model of medaka does not contribute to neurodegeneration2014
    • Author(s)
      Norihito Uemura, Tomoko Fujiwara-Ishikawa, Masato Kinoshita, Masato Koike, Hideaki Matsui, Hodaka Yamakado, Yasuo Uchiyama, Takeshi Todo, Shun-ichi Takeda, Ryosuke Takahashi
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-12
    • Data Source
      KAKENHI-PLANNED-23111002

  • [Presentation] Analysis of the ATP13A2mutant (PARK9) medaka (Oryzias latipes).2014
    • Author(s)
      樽野陽亮、上村紀人、松井秀彰、山門穂高、高橋良輔
    • Organizer
      4th Asian and Oceanian Parkinson’s Disease and Movement Disorders Congress
    • Place of Presentation
      タイ、パタヤ
    • Year and Date
      2014-11-30
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] ATP13A2 変異メダカの解析2014
    • Author(s)
      樽野陽亮、上村紀人、松井秀彰、山門穂高、高橋良輔
    • Organizer
      第55回 日本神経学会学術大会
    • Place of Presentation
      福岡市
    • Year and Date
      2014-05-23
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] Neuronopathic Gaucher’s disease model of medaka displayed axonal accumulation of alpha-synuclein2014
    • Author(s)
      Norihito Uemura, Masato Koike, Masato Kinoshita, Tomoko Fujiwara-Ishikawa, Hideaki Matsui, Hodaka Yamakado,Yasuo Uchiyama, Takeshi Todo, Shun-ichi Takeda, Ryosuke Takahashi
    • Organizer
      4th Asian and Oceanian Parkinson’s Disease and Movement Disorders Congress
    • Place of Presentation
      Thailand
    • Year and Date
      2014-11-30
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] Gene Expression Profiling in Motor Neuron-Specific 26S Proteasome Conditional Knockout Mice.2014
    • Author(s)
      Hoshino T, Yamashita H, Tashiro Y, Misawa H, Takahashi R
    • Organizer
      第37回神経科学大会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-09-12
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] Aβ,細胞死への酸化ストレスの影響に対する神経保護物質の抵抗性のin vitroでの検証2014
    • Author(s)
      宮本将和、小形美果、渡邉究、浅田めぐみ、植村健吾、高橋良輔、木下彩栄
    • Organizer
      第55回 日本神経学会学術大会
    • Place of Presentation
      福岡市
    • Year and Date
      2014-05-23
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] Alpha-synuclein accumulation in Gaucher disease model of medaka does not contribute to neurodegeneration2014
    • Author(s)
      Norihito Uemura, Tomoko Fujiwara-Ishikawa, Masato Kinoshita, Masato Koike, Hideaki Matsui, Hodaka Yamakado, Yasuo Uchiyama, Takeshi Todo, Shun-ichi Takeda and Ryosuke Takahashi
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-09-12
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] Neuronopathic Gaucher’s disease model of medaka displayed axonal accumulation of alpha-synuclein2014
    • Author(s)
      Norihito Uemura, Masato Koike, Masato Kinoshita, Tomoko Fujiwara-Ishikawa4, Hideaki Matsui5, Hodaka Yamakado,Yasuo Uchiyama, Takeshi Todo, Shun-ichi Takeda, Ryosuke Takahashi
    • Organizer
      4th Asian and Oceanian Parkinson’s Disease and Movement Disorders Congress
    • Place of Presentation
      Pattaya (Thailand)
    • Year and Date
      2014-11-30
    • Data Source
      KAKENHI-PROJECT-26670442

  • [Presentation] NF-κB経路を介したOptineurinのノックダウンによる神経細胞死2014
    • Author(s)
      秋月真由美、山下博文、植村健吾、丸山博文、川上秀史、伊東秀文、高橋良輔
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      福岡市
    • Year and Date
      2014-05-23
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] ALSのTDP-43のinclusion形成におけるVon Hippel-Lindau proteinの役割 （ポスター）2014
    • Author(s)
      内田 司、小代明美、守村敏史、辰己新水、高橋良輔、漆谷真
    • Organizer
      第37回日本神経科学学会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-09-14
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] MAPTの新規挿入変異を認めたFTDP17の2家系2014
    • Author(s)
      森野豊之, 平木啓子, 倉重毅志, 和泉唯信, 山崎雄, 高橋哲也, 丸山博文, 伊東秀文, 川上秀史
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2014-05-21
    • Data Source
      KAKENHI-PROJECT-24300132

  • [Presentation] 運動ニューロン特異的26Sプロテアソームノックアウトマウスの遺伝子網羅的解析2014
    • Author(s)
      星野 友則, 山下 博史, 田代 善崇, 三澤 日出巳, 高橋良輔
    • Organizer
      日本Cell death 学会
    • Place of Presentation
      東京都
    • Year and Date
      2014-07-18
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] ATP13A5 変異メダカの解析2014
    • Author(s)
      樽野陽亮、上村紀人、松井秀彰、山門穂高、高橋良輔
    • Organizer
      第8回パーキンソン病・運動障害疾患コングレス
    • Place of Presentation
      京都市
    • Year and Date
      2014-10-02
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] アルツハイマー型認知症剖検脳におけるGADD34の局在の検討2014
    • Author(s)
      本城靖之, 綾木孝, 堀部智久, 富山貴美, 森啓, 伊東秀文, 高橋良輔, 川上浩司
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      福岡国際センター
    • Year and Date
      2014-05-22
    • Data Source
      KAKENHI-PROJECT-24300132

  • [Presentation] Increased synaptic density and improved spatial working memory in N-cadherin shedding deficient knock-in mice Nカドヘリン切断阻害マウスはシナプス密度と空間作業記憶が向上する2014
    • Author(s)
      浅田めぐみ、久保田正和、野田秦葉、上田奈津実、諏訪あゆみ、田代喜崇、上村麻衣子、山門 穂高、下濱俊、高橋良輔、植村健吾、木下専、木下彩栄
    • Organizer
      第37回神経科学大会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-09-11
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] Microarray analysis in spinal cords of sporadic ALS patients with cell-type specific transcriptome2014
    • Author(s)
      Hirofumi Yamashita, Okiru komine, Noriko Fujimori, Hidefumi Ito, Yohei Iguchi, Naoki Atsuta, Fumiaki Tanaka, Gen Sobue, Ryosuke Takahashi, Koji Yamanaka
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-09-13
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] Microarray analysis in spinal cords of sporadic ALS patients with cell-type specific transcriptome2014
    • Author(s)
      Hirofumi Yamashita, Noriko Fujimori, Hidefumi Ito, Yohei Iguchi, Naoki Atsuta, Fumiaki Tanaka, Gen Sobue, Ryosuke Takahashi, Koji Yamanaka
    • Organizer
      Nucleic Acid Summit
    • Place of Presentation
      San Diego
    • Year and Date
      2014-06-19
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] Viable Gaucher' s disease model of medaka fish completely deficienct in glucocerebrosidase activity developed alpha-synuclein aggregation in the brain2013
    • Author(s)
      Uemura N, Fujiwara-Ishikawa T, Kinoshita M, Koike M, Matsui H, Yamakado H, Uemura K, Uchiyama Y, Todo T, Takeda S, Takahashi R
    • Organizer
      Neuroscience 2013
    • Place of Presentation
      SanDiego
    • Year and Date
      2013-11-10
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Presentation] 疾患特異的iPS細胞モデルによるLRRK2変異パーキンソン病の研究2013
    • Author(s)
      小芝泰, 森実飛鳥, 山門穂高, 陣上直人, 菊地哲広, 土井大輔, 皆川栄子, 江川斉宏, 井上治久, 高橋淳, 高橋良輔
    • Organizer
      第7回パーキンソン病・運動障害疾患コングレス
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Presentation] GBAノックアウトメダカは脳にアルファシヌクレイン凝集体を形成する2013
    • Author(s)
      上村紀仁、石川智子、木下政人、小池正人、松井秀彰、山門穂高、植村健吾、内山安男、藤堂剛、武田俊一、高橋良輔
    • Organizer
      第22回日本Cell Death学会学術集会
    • Place of Presentation
      京都市
    • Year and Date
      2013-07-19
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] メダカを用いたGBA変異とパーキンソン病の関連性の解析2013
    • Author(s)
      上村紀仁, 石川智子, 木下政人, 小池正人, 松井秀彰, 山門穂高, 植村健吾, 内山安男, 藤堂剛, 武田俊一, 高橋良輔
    • Organizer
      日本神経学会
    • Place of Presentation
      京都
    • Year and Date
      2013-05-31
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Presentation] α-Synucleinの発現量の調節を標的とするパーキンソン病治療薬剤のスクリーニング2013
    • Author(s)
      浅野剛史、山門穂高、高橋良輔
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Presentation] メダカを用いたGBA変異とパーキンソン病の関連性の解析2013
    • Author(s)
      上村紀仁、石川智子、木下政人、小池正人、松井秀彰、山門穂高、植村健吾、内山安男、藤堂剛、武田俊一、高橋良輔
    • Organizer
      日本神経学会
    • Place of Presentation
      東京都
    • Year and Date
      2013-05-31
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] ATP13A2変異メダカの解析2013
    • Author(s)
      樽野陽亮、谷口善仁、松井秀彰、上村紀仁、山門穂高、高橋良輔
    • Organizer
      日本神経科学学会
    • Place of Presentation
      京都　国際会議場
    • Data Source
      KAKENHI-PLANNED-23111002

  • [Presentation] GBAノックアウトメダカは脳にアルファシヌクレイン凝集体を形成する2013
    • Author(s)
      上村紀仁、石川智子、木下政人、小池正人、松井秀彰、山門穂高、植村健吾、内山安男、藤堂剛、武田俊一、高橋良輔
    • Organizer
      第22回 日本Cell death 学会
    • Place of Presentation
      京都　京都大学
    • Data Source
      KAKENHI-PLANNED-23111002

  • [Presentation] Viable Gaucher's disease model of medaka fish completely deficienct in glucocerebrosidase activity developed alpha-synuclein aggregation in the brain2013
    • Author(s)
      Norihito Uemura, Tomoko Fujiwara-Ishikawa, Masato Kinoshita, Masato Koike, Hideaki Matsui, Hodaka Yamakado, Kengo Uemura, Yasuo Uchiyama, Takeshi Todo, Shun-ichi Takeda and Ryosuke Takahashi
    • Organizer
      17th international congress of Parkinson's disease and movement disorders
    • Place of Presentation
      Sydney
    • Data Source
      KAKENHI-PLANNED-23111002

  • [Presentation] Exploring the molecular mechanism underlying Parkinson' s diease with genetic medaka models2013
    • Author(s)
      Takahashi R
    • Organizer
      International Symposium on Mitochondria 2013
    • Place of Presentation
      Tokyo
    • Year and Date
      2013-11-06
    • Invited
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Presentation] マウスを用いたゾニサミドの作用機序の解析2013
    • Author(s)
      浅野剛史、山門穂高、高橋良輔
    • Organizer
      第７回　パーキンソン病・運動障害疾患コングレス
    • Place of Presentation
      東京都
    • Year and Date
      2013-10-11
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] Viable Gaucher' s disease model of medaka fish completely deficienct in glucocerebrosidase activity developed alpha-synuclein aggregation in the brain2013
    • Author(s)
      Uemura N, Fujiwara-Ishikawa T, Kinoshita M, Koike M, Matsui H, Yamakado H, Uemura K, Uchiyama Y, Todo T, Takeda S, Takahashi R
    • Organizer
      日本神経科学学会
    • Place of Presentation
      京都
    • Year and Date
      2013-06-22
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Presentation] Therapeutic approach to Parkinson's disease by modifying α-synuclein expression.2013
    • Author(s)
      Yamakado H, Asano T, Takahashi, R
    • Organizer
      The MDS 17th International Congress of Parkinson's Disease and Movement Disorders
    • Place of Presentation
      Sydney
    • Data Source
      KAKENHI-PLANNED-23111002

  • [Presentation] Viable Gaucher's disease model of medaka fish completely deficienct in glucocerebrosidase activity developed alpha-synuclein aggregation in the brain2013
    • Author(s)
      Norihito Uemura1, Tomoko Fujiwara-Ishikawa2, Masato Kinoshita3, Masato Koike6, Hideaki Matsui, Hodaka Yamakado, Kengo Uemura, Yasuo Uchiyama, Takeshi Todo, Shun-ichi Takeda and Ryosuke Takahashi
    • Organizer
      日本神経科学学会
    • Place of Presentation
      京都　国際会議場
    • Data Source
      KAKENHI-PLANNED-23111002

  • [Presentation] Viable Gaucher' s disease model of medaka fish completely deficienct in glucocerebrosidase activity developed alpha-synuclein aggregation in the brain2013
    • Author(s)
      Uemura N, Fujiwara-Ishikawa T, Kinoshita M, Koike M, Matsui H, Yamakado H, Uemura K, Uchiyama Y, Todo T, Takeda S, Takahashi R
    • Organizer
      17th international congress of Parkinson' s disease and movement disorders
    • Place of Presentation
      Sydney
    • Year and Date
      2013-06-20
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Presentation] ATP13A2変異メダカの解析2013
    • Author(s)
      樽野陽亮、谷口善仁、松井秀彰、上村紀仁、山門穂高、高橋良輔
    • Organizer
      第５４回日本神経学会学術大会
    • Place of Presentation
      東京　東京国際フォーラム
    • Data Source
      KAKENHI-PLANNED-23111002

  • [Presentation] NF-κB経路を介したOptineurinのノックダウンによる神経細胞死2013
    • Author(s)
      秋月 真由 美, 山下博文, 植村健吾, 丸山博文, 川上秀史, 伊東秀文, 高橋良輔
    • Organizer
      第22回日本Cell Death学会
    • Place of Presentation
      京都
    • Year and Date
      2013-07-19
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Presentation] Parkinson's disease by modifying α-synuclein expression.2013
    • Author(s)
      Hodaka Yamakado, Takeshi Asano, Ryosuke Takahashi
    • Organizer
      The MDS 17th International Congress of Parkinson's Disease and Movement Disorders
    • Place of Presentation
      Sydney
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Presentation] Microarray analysis in spinal cords of sporadic ALS patients with cell-type specific transcriptome.2013
    • Author(s)
      Hirofumi Yamashita, Noriko Fujimori, Hidefumi Ito, Yohei Iguchi, Naoki Atsuta, Fumiaki Tanaka, Gen Sobue, Ryosuke Takahashi, Koji Yamanaka.
    • Organizer
      Neuro2013
    • Place of Presentation
      京都市
    • Year and Date
      2013-06-21
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] Exploring the molecular mechanism underlying Parkinson's diease with genetic medaka models.2013
    • Author(s)
      Ryosuke Takahashi
    • Organizer
      International Symposium on Mitochondria 2013
    • Place of Presentation
      Tokyo
    • Invited
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Presentation] Exploring the molecular mechanism underlying Parkinson's diease with genetic medaka models.2013
    • Author(s)
      Ryosuke Takahashi
    • Organizer
      International Symposium on Mitochondria 2013
    • Place of Presentation
      東京都
    • Year and Date
      2013-11-06
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] Neurodegeneration, molecular mechanism, Parkinson's diease, animal model, medaka, mouse.2013
    • Author(s)
      Ryosuke Takahashi
    • Organizer
      Swiss-Kyoto Symposium
    • Place of Presentation
      京都市
    • Year and Date
      2013-11-22
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] Viable Gaucher's disease model of medaka fish completely deficienct in glucocerebrosidase activity developed alpha-synuclein aggregation in the brain2013
    • Author(s)
      Norihito Uemura, Tomoko Fujiwara-Ishikawa, Masato Kinoshita, Masato Koike, Hideaki Matsui, Hodaka Yamakado, Kengo Uemura, Yasuo Uchiyama, Takeshi Todo, Shun-ichi Takeda and Ryosuke Takahashi
    • Organizer
      17th international congress of Parkinson's disease and movement disorders
    • Place of Presentation
      Ｓｙｄｎｅｙ
    • Year and Date
      2013-06-20
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] NF-κB経路を介したOptineurinのノックダウンによる神経細胞死2013
    • Author(s)
      秋月真由美, 山下博文, 植村健吾, 丸山博文, 川上秀史, 伊東秀文, 高橋良輔
    • Organizer
      Neuro2013
    • Place of Presentation
      京都
    • Year and Date
      2013-06-20
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Presentation] Viable Gaucher's disease model of medaka fish completely deficienct in glucocerebrosidase activity developed alpha-synuclein aggregation in the brain2013
    • Author(s)
      Norihito Uemura, Tomoko Fujiwara-Ishikawa, Masato Kinoshita, Masato Koike, Hideaki Matsui, Hodaka Yamakado, Kengo Uemura, Yasuo Uchiyama, Takeshi Todo, Shun-ichi Takeda and Ryosuke Takahashi
    • Organizer
      Neuroscience 2013
    • Place of Presentation
      SanDiego
    • Data Source
      KAKENHI-PLANNED-23111002

  • [Presentation] Viable Gaucher's disease model of medaka fish completely deficienct in glucocerebrosidase activity developed alpha-synuclein aggregation in the brain.2013
    • Author(s)
      Norihito Uemura, Tomoko Fujiwara-Ishikawa, Masato Kinoshita, Masato Koike, Hideaki Matsui, Hodaka Yamakado, Kengo Uemura, Yasuo Uchiyama, Takeshi Todo, Shun-ichi Takeda, Ryosuke Takahashi.
    • Organizer
      Neuroscience 2013
    • Place of Presentation
      SanDiego
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Presentation] Neurodegeneration, molecular mechanism, Parkinson's diease, animal model, medaka, mouse.2013
    • Author(s)
      Ryosuke Takahashi
    • Organizer
      Swiss-Kyoto Symposium
    • Place of Presentation
      京都　京都大学
    • Data Source
      KAKENHI-PLANNED-23111002

  • [Presentation] PINK1とParkinは脊椎動物において相補的にミトコンドリアを保護する2013
    • Author(s)
      浅野剛史, 松井秀彰, Robert Gavinio, 上村紀人, 伊東秀文, 谷口 善仁, Jie Shen, 武田俊一, 植村健吾, 山門穂高, 高橋良輔
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸
    • Year and Date
      2013-12-14
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Presentation] NF-κB経路を介したOptineurinのノックダウンによる神経細胞死2013
    • Author(s)
      20.秋月真由美、山下博文、植村健吾、丸山博文、川上秀史、伊東秀文、高橋良輔
    • Organizer
      Neuro2013
    • Place of Presentation
      京都市
    • Year and Date
      2013-11-12
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] Viable Gaucher's disease model of medaka fish completely deficienct in glucocerebrosidase activity developed alpha-synuclein aggregation in the brain2013
    • Author(s)
      Norihito Uemura, Tomoko Fujiwara-Ishikawa, Masato Kinoshita, Masato Koike, Hideaki Matsui, Hodaka Yamakado, Kengo Uemura, Yasuo Uchiyama, Takeshi Todo, Shun-ichi Takeda and Ryosuke Takahashi
    • Organizer
      Neuroscience 2013
    • Place of Presentation
      SanDiego
    • Year and Date
      2013-11-10
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] メダカを用いたGBA変異とパーキンソン病の関連性の解析2013
    • Author(s)
      上村紀仁、石川智子、木下政人、小池正人、松井秀彰、山門穂高、植村健吾、内山安男、藤堂剛、武田俊一、高橋良輔
    • Organizer
      日本神経学会
    • Place of Presentation
      東京　東京国際フォーラム
    • Data Source
      KAKENHI-PLANNED-23111002

  • [Presentation] 既存薬によるSOD1転写を標的とした筋委縮性側索硬化症新規治療法の開発2013
    • Author(s)
      村上学, 井上治久, 月田香代子, 淺井康行, 饗庭一博, 天貝裕地, 山下博史, 植村健吾, 伊東秀文, 下川浩輝, 上杉志成, 中辻憲夫, 高橋良輔
    • Organizer
      第54回日本神経学会総会学術大会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24300132

  • [Presentation] ATP13A2変異メダカの解析2013
    • Author(s)
      樽野陽亮、谷口善仁、松井秀彰、上村紀仁、山門穂高、高橋良輔
    • Organizer
      日本神経科学学会
    • Place of Presentation
      京都市
    • Year and Date
      2013-06-22
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] NF-κB経路を介したOptineurinのノックダウンによる神経細胞死2013
    • Author(s)
      秋月真由美、山下博史、植村健吾、丸山博文、川上秀史、伊東秀文、高橋良輔
    • Organizer
      第22回 cell death学会
    • Place of Presentation
      京都　京都大学
    • Data Source
      KAKENHI-PLANNED-23111002

  • [Presentation] ATP13A2変異メダカの解析2013
    • Author(s)
      樽野陽亮、谷口善仁、松井秀彰、上村紀仁、山門穂高、高橋良輔
    • Organizer
      第７回パーキンソン病・運動障害疾患コングレス
    • Place of Presentation
      東京 京王プラザホテル
    • Data Source
      KAKENHI-PLANNED-23111002

  • [Presentation] Viable Gaucher's disease model of medaka fish completely deficienct in glucocerebrosidase activity developed alpha-synuclein aggregation in the brain2013
    • Author(s)
      Norihito Uemura, Tomoko Fujiwara-Ishikawa, Masato Kinoshita, Masato Koike, Hideaki Matsui, Hodaka Yamakado, Kengo Uemura, Yasuo Uchiyama, Takeshi Todo, Shun-ichi Takeda and Ryosuke Takahashi
    • Organizer
      日本神経科学学会
    • Place of Presentation
      京都市
    • Year and Date
      2013-06-22
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] ADAM10切断阻害変異導入N-カドヘリンマウスの解析2013
    • Author(s)
      浅田めぐみ、久保田正和、野田泰葉、上田奈津実、諏訪あゆみ、田代善崇、山門穂高、下濱俊、高橋良輔、植村健吾、木下専、木下彩栄
    • Organizer
      第36回 日本分子生物学会
    • Place of Presentation
      神戸市
    • Year and Date
      2013-12-05
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] Therapeutic approach to Parkinson's disease by modifying α-synuclein expression.2013
    • Author(s)
      Yamakado H, Asano T, Takahashi, R
    • Organizer
      The MDS 17th International Congress of Parkinson's Disease and Movement Disorders
    • Place of Presentation
      Sydney
    • Year and Date
      2013-06-17
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] Fish model of Parkinson's disease2013
    • Author(s)
      Ryosuke Takahashi
    • Organizer
      Swiss-Kyoto Symposium
    • Place of Presentation
      Kyoto
    • Invited
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Presentation] PINK1とParkinは脊椎動物において相補的にミトコンドリアを保護する2013
    • Author(s)
      浅野剛史, 松井秀彰, Robert Gavinio, 上村紀人, 伊東秀文, 谷口 善仁, Jie Shen, 武田俊一, 植村健吾, 山門穂高, 高橋良輔
    • Organizer
      第22回日本CellDeath学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2013-07-19
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Presentation] ADAM10 切断阻害変異導入N-カドヘリンマウスの解析2013
    • Author(s)
      浅田めぐみ、諏訪あゆみ、久保田正和、野田泰葉、田代善崇、前迫真人、山門穂高、下濱俊、高橋良輔、植村健吾、木下彩栄
    • Organizer
      Neuro2013
    • Place of Presentation
      京都市
    • Year and Date
      2013-06-20
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] α-Synucleinの発現量の調節を標的とするパーキンソン病治療薬剤のスクリーニング2013
    • Author(s)
      浅野剛史、山門穂高、高橋良輔
    • Organizer
      Neuro2013
    • Place of Presentation
      京都市
    • Year and Date
      2013-06-20
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] 疾患特異的iPS細胞モデルによる遺伝性パーキンソン病の研究2013
    • Author(s)
      小芝泰, 森実飛鳥, 山門穂高, 菊地哲広, 皆川栄子, 土井大輔, 西村周泰江川斉宏, 井上治久, 高橋淳, 高橋良輔
    • Organizer
      第54回日本神経学会学術総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Presentation] マウスを用いたゾニサミドの作用機序の解析2013
    • Author(s)
      浅野剛史, 山門穂高, 高橋良輔
    • Organizer
      第7回パーキンソン病・運動障害疾患コングレス
    • Place of Presentation
      東京
    • Year and Date
      2013-10-11
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Presentation] ATP13A2変異メダカの解析2013
    • Author(s)
      樽野陽亮、谷口善仁、松井秀彰、上村紀仁、山門穂高、高橋良輔
    • Organizer
      第５４回日本神経学会学術大会
    • Place of Presentation
      東京都
    • Year and Date
      2013-05-31
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] 疾患特異的iPS細胞モデルによる遺伝性パーキンソン病の研究2013
    • Author(s)
      小芝泰, 森実飛鳥, 山門穂高, 菊地哲広, 土井大輔, 西村周泰, 皆川栄子, 江川斉宏, 近藤孝之, 井上治久, 高橋淳, 高橋良輔
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Presentation] α-Synucleinの発現量の調節を標的とするパーキンソン病治療薬剤のスクリーニング2013
    • Author(s)
      浅野剛史、山門穂高、高橋良輔
    • Organizer
      Neuro2013
    • Place of Presentation
      京都　国際会議場
    • Data Source
      KAKENHI-PLANNED-23111002

  • [Presentation] α-Synucleinの発現量の調節を標的とするパーキンソン病治療薬剤のスクリーニング2013
    • Author(s)
      浅野剛史, 山門穂高, 高橋良輔
    • Organizer
      Neuro2013
    • Place of Presentation
      京都
    • Year and Date
      2013-06-20
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Presentation] マウスを用いたゾニサミドの作用機序の解析2013
    • Author(s)
      浅野剛史、山門穂高、高橋良輔
    • Organizer
      第７回　パーキンソン病・運動障害疾患コングレス
    • Place of Presentation
      東京　京王プラザホテル
    • Data Source
      KAKENHI-PLANNED-23111002

  • [Presentation] 孤発性筋萎縮性側索硬化症の脊髄におけるESCRT関連分子の免疫組織化学的検討2013
    • Author(s)
      池本明人, 八木彩香, 綾木孝, 田代善崇, 中谷嘉文, 澤本伸克, 伊東秀文, 高橋良輔
    • Organizer
      第54回日本神経学会総会学術大会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24300132

  • [Presentation] GBAノックアウトメダカは脳にアルファシヌクレイン凝集体を形成する2013
    • Author(s)
      上村紀仁, 石川智子, 木下政人, 小池正人, 松井秀彰, 山門穂高, 植村健吾, 内山安男, 藤堂剛, 武田俊一, 高橋良輔
    • Organizer
      第22回日本Cell death学会
    • Place of Presentation
      京都
    • Year and Date
      2013-07-19
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Presentation] Neurodegeneration, molecular mechanism, Parkinson' s diease, animal model, medaka, mouse2013
    • Author(s)
      Takahashi R
    • Organizer
      Swiss-Kyoto Symposium
    • Place of Presentation
      Kyoto
    • Year and Date
      2013-11-22
    • Invited
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Presentation] Therapeutic approach to Parkinson' s disease by modifying α -synuclein expression2013
    • Author(s)
      Yamakado H, Asano T, Takahashi R
    • Organizer
      The MDS 17th International Congress of Parkinson' s Disease and Movement Disorders
    • Place of Presentation
      Sydney
    • Year and Date
      2013-06-17
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Presentation] NF-κB経路を介したOptineurinのノックダウンによる神経細胞死2013
    • Author(s)
      秋月真由美、山下博文、植村健吾、丸山博文、川上秀史、伊東秀文、高橋良輔
    • Organizer
      第22回日本cell death学会学術集会
    • Place of Presentation
      京都市
    • Year and Date
      2013-07-19
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] NF-κB経路を介したOptineurinのノックダウンによる神経細胞死2013
    • Author(s)
      秋月真由美、山下博文、植村健吾、丸山博文、川上秀史、伊東秀文、高橋良輔
    • Organizer
      Neuro2013
    • Place of Presentation
      京都　国際会議場
    • Data Source
      KAKENHI-PLANNED-23111002

  • [Presentation] ATP13A2変異メダカの解析2013
    • Author(s)
      樽野陽亮、谷口善仁、松井秀彰、上村紀仁、山門穂高、高橋良輔
    • Organizer
      第７回パーキンソン病・運動障害疾患コングレス
    • Place of Presentation
      東京都
    • Year and Date
      2013-10-11
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] CONGNITIVE AND PHYCHIATRIC FEATURES IN ANIMAL PD MODELS.2012
    • Author(s)
      Takahashi R
    • Organizer
      8th International Congress On Mental Dysfunction Other Non-Motor Features In Parkinson’s Diease and Related Disorders
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      2012-05-04
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-23111001

  • [Presentation] Regulation of the PINK1 signaling by mitochondrial protein PGAM52012
    • Author(s)
      澤田知世, 高橋良輔
    • Organizer
      Neuroscience 2012
    • Place of Presentation
      ニューオーリンズ
    • Year and Date
      2012-10-15
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Presentation] パーキンソン病の分子病態2012
    • Author(s)
      高橋良輔
    • Organizer
      第8回Clinician-Scientist育成セミナー
    • Place of Presentation
      山口
    • Year and Date
      2012-03-07
    • Invited
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Presentation] FUS-immunopositive Inclusions and Compound Pick Bodies in Two Cases of Frontotemporal Lobar Degeneration with Motor Neuron Disease (FTLDMND).2012
    • Author(s)
      Nakamoto F, Takao M, Ikemura M, Hayashi T, Ito S, Maeda D, SaitoY, Takahashi Y, Hasegawa M, Fukayama M, Tsuji S, Murayama S
    • Organizer
      The 8th International Conference on Frontotemporal Dementias.
    • Place of Presentation
      Manchester, UK.
    • Data Source
      KAKENHI-PROJECT-221S0003

  • [Presentation] パーキンソン病の分子病態2012
    • Author(s)
      高橋良輔
    • Organizer
      第50回日本神経眼科学会総会
    • Place of Presentation
      京都
    • Year and Date
      2012-11-16
    • Invited
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Presentation] 孤発性筋萎縮性側索硬化症の脊髄におけるangiogenin発現の検討2012
    • Author(s)
      池本明人, 綾木孝, 猪原匡史, 平野朝雄, 高橋良輔, 伊東秀文
    • Organizer
      第53回 日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2012-05-23
    • Data Source
      KAKENHI-PROJECT-24300132

  • [Presentation] CONGNITIVE AND PHYCHIATRIC FEATURES IN ANIMAL PD MODELS2012
    • Author(s)
      Takahashi R, H. Yamakado H, Gavinio R
    • Organizer
      8th International Congress On Mental Dysfunction & Other Non-Motor Features In Parkinson' s Diease and Related Disorders
    • Place of Presentation
      Inter Continental Berlin, Germany
    • Year and Date
      2012-05-04
    • Invited
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Presentation] CONGNITIVE AND PHYCHIATRIC FEATURES IN ANIMAL PD MODELS.2012
    • Author(s)
      Takahashi R
    • Organizer
      8th International Congress On Mental Dysfunction & Other Non-Motor Features In Parkinson’s Diease and Related Disorders
    • Place of Presentation
      Berlin, Germany
    • Invited
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Presentation] CONGNITIVE AND PHYCHIATRIC FEATURES IN ANIMAL PD MODELS.2012
    • Author(s)
      Takahashi R
    • Organizer
      8th International Congress On Mental Dysfunction Other Non-Motor Features In Parkinson’s Diease and Related Disorders
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      2012-05-04
    • Invited
    • Data Source
      KAKENHI-PLANNED-23111002

  • [Presentation] BACテクノロジーを用いたパーキンソン病の治療薬候補の探索2012
    • Author(s)
      浅野剛史, 山門穂高, 高橋良輔
    • Organizer
      第6回パーキンソン病・運動障害疾患コングレス
    • Place of Presentation
      京都
    • Year and Date
      2012-10-13
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Presentation] Valosin Containing Protein遺伝子に新規変異を認めた筋萎縮性側索硬化症・Paget病の剖検例2012
    • Author(s)
      綾木孝, 伊東秀文, 近藤孝之, 福島裕子, 井上健, 池本明人, 中野智, 藤田拓司, 山下博史, 猪原匡史, 松本理器, 川又純, 高橋良輔
    • Organizer
      第53回 日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2012-05-25
    • Data Source
      KAKENHI-PROJECT-24300132

  • [Presentation] パーキンソン病のメダカモデル神経疾患の克服に向けて2012
    • Author(s)
      高橋良輔
    • Organizer
      大阪大学蛋白質研究所セミナー
    • Place of Presentation
      大阪大学
    • Invited
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Presentation] Molecular mechanisms underlying Parkin/PINK1-related Parkinson's disease2011
    • Author(s)
      Ryosuke Takahashi
    • Organizer
      International Symposium "Parkinson Disease and Mitophagy"
    • Place of Presentation
      東京歯科大学講堂(招待講演)
    • Year and Date
      2011-06-11
    • Data Source
      KAKENHI-PLANNED-23111002

  • [Presentation] 神経疾患に対する細胞治療の開発-現状と展望2011
    • Author(s)
      高橋良輔
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋国際会議場(招待講演)
    • Year and Date
      2011-05-20
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Presentation] 慢性脳低灌流はタウオパチーモデルマウスのタウ毒性を加速する2011
    • Author(s)
      山田真人, (2名略)、伊東秀文, (2名略)、高橋良輔
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋(名古屋国際会議場)
    • Year and Date
      2011-05-19
    • Data Source
      KAKENHI-PROJECT-21500336

  • [Presentation] 変異SOD1を有するALS患者由来iPS細胞の樹立とアストロサイトへの分化2011
    • Author(s)
      北岡志保, (8名略)、伊東秀文, (8名略)、高橋良輔, (1名略)
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋(名古屋国際会議場)
    • Year and Date
      2011-05-19
    • Data Source
      KAKENHI-PROJECT-21500336

  • [Presentation] Alzheimer病患者脳内におけるHtrA2/Omiの免疫組織化学的検討2011
    • Author(s)
      河本恭裕、伊東秀文, (2名略)、高橋良輔
    • Organizer
      第52回日本神経病理学会総会
    • Place of Presentation
      京都(京都テルサ)
    • Year and Date
      2011-06-04
    • Data Source
      KAKENHI-PROJECT-21500336

  • [Presentation] Establishment of iPS cells from amyotrophic lateral sclerosis model mice and motor neuronal differentiation2011
    • Author(s)
      Komatsu K., Inoue H., Kondo T., Kitaoka S., Takahashi R
    • Organizer
      The XXth World Congress of Neurology
    • Place of Presentation
      Marrakesh, Morocco
    • Year and Date
      2011-11-16
    • Data Source
      KAKENHI-PROJECT-21591079

  • [Presentation] Chemical library screening identifies a small molecule that down regulates SOD1 transcription for drugs to treat amyotrophic lateral sclerosis2011
    • Author(s)
      Murakami G, Inoue H, Tsukita K, Asai Y, Amagai Y, Aiba K, Shimogawa H, Uesugi M, Nakatsuji N, Takahashi R
    • Organizer
      The 34th Annual Meeting of the Japan Neuroscience Society. Neuroscience of the Mind
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2011-09-15
    • Data Source
      KAKENHI-PROJECT-21591079

  • [Presentation] Multiple System Atrophy-update in Diagnosis and Etiopathogenesis.2011
    • Author(s)
      Takahashi R.
    • Organizer
      3^<rd> Asian and Oceanian Parkinson's Disease and Movement Disorders Congress(AOPMC 2011)
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2011-03-26
    • Data Source
      KAKENHI-PROJECT-20390244

  • [Presentation] 遺伝性パーキンソン病2011
    • Author(s)
      高橋良輔
    • Organizer
      第5回パーキンソン病・運動障害疾患コングレス
    • Place of Presentation
      東京
    • Year and Date
      2011-10-06
    • Data Source
      KAKENHI-PUBLICLY-23110507

  • [Presentation] モントリオール認知評価法MoCAはMMSEよりも皮質下血管性認知障害の検出感度が高い2011
    • Author(s)
      猪原匡史, (1名略)、伊東秀文、高橋良輔
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋(名古屋国際会議場)
    • Year and Date
      2011-05-18
    • Data Source
      KAKENHI-PROJECT-21500336

  • [Presentation] 脳低灌流がアミロイド血管症による虚血・出血を加速する2011
    • Author(s)
      岡本洋子, (3名略)、伊東秀文, (3名略), 高橋良輔
    • Organizer
      第52回日本神経病理学会総会
    • Place of Presentation
      京都(京都テルサ)
    • Year and Date
      2011-06-03
    • Data Source
      KAKENHI-PROJECT-21500336

  • [Presentation] Establishment of iPS cells from amyotrophic lateral sclerosis model mice and motor neuronal differentiation2011
    • Author(s)
      Komatsu K., Inoue H., Kondo I, Kitaoka S., Takahashi K., Yamanaka S., Takahashi R.
    • Organizer
      The 34th Annual Meeting of the Japan Neuroscience Society-Neuroscience of the Mind-
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2011-09-15
    • Data Source
      KAKENHI-PROJECT-21591079

  • [Presentation] Molecular mechanisms underlying Parkin/PINK1-related Parkinson's disease2011
    • Author(s)
      Ryosuke Takahashi
    • Organizer
      International Symposium "Parkinson Disease and Mitophagy"
    • Place of Presentation
      東京医科歯科大学講堂(招待講演)
    • Year and Date
      2011-06-11
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Presentation] 変異SOD1を有するALS患者由来iPS細胞の樹立とアストロサイトへの分化2011
    • Author(s)
      北岡志保, 井上治久, 月田香代子, 高橋和利, 近藤孝之, 吉川勝宇, 山脇聖子, 内藤素子, 鈴木茂彦, 伊東秀文, 和泉唯信, 梶龍兒, 宅間浩, 玉岡晃, 森田光哉, 中野今治, 川田明広, 中畑龍俊, 高橋良輔, 山中伸弥
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-05-19
    • Data Source
      KAKENHI-PROJECT-21591079

  • [Presentation] パーキンソン病の治療と研究の最近の進歩2011
    • Author(s)
      高橋良輔
    • Organizer
      第122回山口県医師会生涯研修セミナー平成23年度第3回日本医師会生涯教育講座山口県特定疾患専門医師研修会
    • Place of Presentation
      山口
    • Year and Date
      2011-11-27
    • Invited
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Presentation] HECT型ユビキチンリガーゼMule/Huwe1によるPINK1安定性の調節2011
    • Author(s)
      澤田知世, 金尾智子, 小林芳人, 高橋良輔, 今井譲
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-05-18
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Presentation] 脳幹型および皮質型Lewy小体におけるXIAPとHtrA2/Omiの共存2011
    • Author(s)
      河本恭裕、伊東秀文, (3名略)、高橋良輔
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋(名古屋国際会議場)
    • Year and Date
      2011-05-18
    • Data Source
      KAKENHI-PROJECT-21500336

  • [Presentation] 神経疾患に対する細胞治療の開発-現状と展望2011
    • Author(s)
      高橋良輔
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋国際会議場(招待講演)
    • Year and Date
      2011-05-20
    • Data Source
      KAKENHI-PLANNED-23111002

  • [Presentation] シロスタゾールによるrtPA治療後の出血、浮腫の抑制効果2011
    • Author(s)
      長谷佳樹, (2名略)、伊東秀文、高橋良輔
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋(名古屋国際会議場)
    • Year and Date
      2011-05-19
    • Data Source
      KAKENHI-PROJECT-21500336

  • [Presentation] Molecular mechanisms underlying Parkin / PINK1-related Parkinson ' s disease2011
    • Author(s)
      Takahashi R
    • Organizer
      International Symposium Parkinson Disease and Mitophagy
    • Place of Presentation
      Tokyo
    • Year and Date
      2011-06-11
    • Invited
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Presentation] The HECT-Type ubiquitin ligase Huwe1/Mule mediates the stability of PINK12011
    • Author(s)
      Sawada T, Kanao T, Kobayashi Y, Takahashi R, Imai Y
    • Organizer
      The 34th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Yokohama
    • Year and Date
      2011-09-17
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Presentation] 筋萎縮性側索硬化症に於けるvalosin-containing protein発現の検討2011
    • Author(s)
      池本明人, (2名略)、高橋良輔、伊東秀文
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋(名古屋国際会議場)
    • Year and Date
      2011-05-18
    • Data Source
      KAKENHI-PROJECT-21500336

  • [Presentation] パーキンソン病遺伝子治療の是非2011
    • Author(s)
      高橋良輔
    • Organizer
      第26回日本大脳基底核研究会
    • Place of Presentation
      第 26 回日 本大脳基底核研究会
    • Year and Date
      2011-07-02
    • Invited
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Presentation] 中枢神経疾患に対する細胞治療御展望と課題(オーバービュー)シンポジウム23 : 神経疾患に対する細胞治療の開発-現状と展望2011
    • Author(s)
      高橋良輔
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-05-20
    • Invited
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Presentation] PINK1 and Parkin regulate the mitochondrial transport machinery2011
    • Author(s)
      Sawada T, Liu S, Kanao T, Lu B, Hattori N, Takahashi R. Imai Y
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-14
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Presentation] 神経変性モデル作製のための26Sロテアソームコンディショナルノックアウトマウスの確立と解析2011
    • Author(s)
      田代善崇、伊東秀文, (5名略)、高橋良輔
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋(名古屋国際会議場)
    • Year and Date
      2011-05-19
    • Data Source
      KAKENHI-PROJECT-21500336

  • [Presentation] 神経疾患に対する細胞治療の開発-現状と展望2011
    • Author(s)
      高橋良輔
    • Organizer
      第52回日本神経学会学術大会/シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2011-05-20
    • Data Source
      KAKENHI-PUBLICLY-23110507

  • [Presentation] 転写を標的とした家族性筋萎縮性側索硬化症新規治療法の開発2011
    • Author(s)
      村上学, 井上治久, 月田香代子, 淺井康行, 饗庭一博, 天貝裕地, 下川浩輝, 上杉志成, 中辻憲夫, 高橋良輔
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-05-19
    • Data Source
      KAKENHI-PROJECT-21591079

  • [Presentation] GBA変異とパーキンソン病の関係2011
    • Author(s)
      上村紀仁, 石川智子, 藤堂剛, 高橋良輔
    • Organizer
      第5回パーキンソン病・運動障害疾患コングレス
    • Place of Presentation
      東京
    • Year and Date
      2011-10-07
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Presentation] アメロイドコンストリクターを用いた新規ラット皮質下血管性認知症モデルの作成2011
    • Author(s)
      北村彰浩, (4名略)、伊東秀文、高橋良輔
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋(名古屋国際会議場)
    • Year and Date
      2011-05-19
    • Data Source
      KAKENHI-PROJECT-21500336

  • [Presentation] GBA変異とパーキンソン病の関係2011
    • Author(s)
      上村紀仁、高橋良輔, 他
    • Organizer
      第5回パーキンソン病・運動障害疾患コングレス
    • Place of Presentation
      東京
    • Year and Date
      2011-10-07
    • Data Source
      KAKENHI-PUBLICLY-23110507

  • [Presentation] マウス慢性脳低灌流モデルの認知機能障害および白質病変に対するニフェジピンの効果2011
    • Author(s)
      鷲田和夫, (1名略)、伊東秀文, (1名略)、高橋良輔
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋(名古屋国際会議場)
    • Year and Date
      2011-05-19
    • Data Source
      KAKENHI-PROJECT-21500336

  • [Presentation] 筋萎縮性側索硬化症モデルマウスiPS細胞の樹立および運動ニューロンへの分化2011
    • Author(s)
      小松研一, 井上治久, 近藤孝之, 北岡志保, 一阪朋子, 高橋和利, 山中伸弥, 高橋良輔
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-05-19
    • Data Source
      KAKENHI-PROJECT-21591079

  • [Presentation] 霊長類多発脳梗塞モデルのMRI画像2011
    • Author(s)
      眞木崇州, (6名略)、伊東秀文、高橋良輔, (1名略)
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋(名古屋国際会議場)
    • Year and Date
      2011-05-18
    • Data Source
      KAKENHI-PROJECT-21500336

  • [Presentation] 遺伝性パーキンソン病2011
    • Author(s)
      高橋良輔
    • Organizer
      第5回パーキンソン病・運動障害疾患コングレス
    • Place of Presentation
      東京
    • Year and Date
      2011-10-06
    • Invited
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Presentation] 脳低灌流がアミロイド血管症による虚血・出血を加速する2011
    • Author(s)
      岡本洋子, (3名略)、伊東秀文, (3名略)、高橋良輔
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋(名古屋国際会議場)
    • Year and Date
      2011-05-20
    • Data Source
      KAKENHI-PROJECT-21500336

  • [Presentation] Induction of astrocyte differentiation from human induced pluripotent stem cells carrying mutant SOD12011
    • Author(s)
      Kitaoka S, Tsukita K, Takahashi K, Okita K, Kondo T, Yoshikawa K, Yamawaki S, Naitoh M, Suzuki S, Izumi Y, Kaji R, Takuma H, Tamaoka A, Morita M, Nakano I, Kawata A, Nakahata T, Takahashi R, Yamanaka S, Inoue H
    • Organizer
      The 34th Annual Meeting of the Japan Neuroscience Society. Neuroscience of the Mind
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2011-09-16
    • Data Source
      KAKENHI-PROJECT-21591079

  • [Presentation] Chemical library screening identifies a small Molecule that downregulates SOD1 transcription for drugs to treat amyotrophic lateral sclerosis2011
    • Author(s)
      Murakami G., Inoue H., Tsukita K., Asai Y., Amagai Y., Aiba K., Shimogawa H., Uesugi M., Nakatsuji N., Takahashi R.
    • Organizer
      The 34th Annual Meeting of the Japan Neuroscience Society-Neuroscience of the Mind-
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2011-09-15
    • Data Source
      KAKENHI-PROJECT-21591079

  • [Presentation] Induction of astrocyte differentiation from human induced pluripotent stem cells carrying Mutant SOD12011
    • Author(s)
      Kitaoka S., Tsukita K., Takahashi K., Okita K., Kondo T., Yoshikawa K., Yamawaki S., Naitoh M., Suzuki S., Izumi Y., Kaji R., Takuma H., Tamaoka A., Morita M., Nakano I., Kawata A., Nakahata T., Takahashi R., Yamanaka S., Inoue H.
    • Organizer
      The 34 th Annual Meeting of the Japan Neuroscience Society-Neuroscience of the Mind-
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2011-09-16
    • Data Source
      KAKENHI-PROJECT-21591079

  • [Presentation] Decreased anxiety-like behavior in alpha-synuclein BAC transgenic mice recapitulates early non-motor symptoms in Parkinson disease2011
    • Author(s)
      Yamakado H, Moriwaki Y, Ymazaki N, Kurisu J, Miyagawa T, Uemura K, Inoue H, Takahashi R
    • Organizer
      The 34th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Yokohama
    • Year and Date
      2011-09-15
    • Data Source
      KAKENHI-PROJECT-23390232

  • [Presentation] 筋萎縮性側索硬化症の脊髄に於けるvalosin-containing proteinの免疫組織化学的検討2011
    • Author(s)
      池本明人, (2名略)、高橋良輔、伊東秀文
    • Organizer
      第52回日本神経病理学会総会
    • Place of Presentation
      京都(京都テルサ)
    • Year and Date
      2011-06-04
    • Data Source
      KAKENHI-PROJECT-21500336

  • [Presentation] Transcription-targeted drug discovery for SOD1-mediated ALS using high-throughput screening technique.2010
    • Author(s)
      Murakami, G., Inoue, H., Tsukito, K., Asai, Y., Amagai, Y., Aiba, K., Uesugi, M., Nakatsuji, N., Takahashi, R.
    • Organizer
      The 40th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2010-11-17
    • Data Source
      KAKENHI-PROJECT-21591079

  • [Presentation] Cortical microinfarcts are related to cerebral amyloid angiopathy rather than to senile plaques or neurofibrillary tangles2010
    • Author(s)
      Okamoto Y, Ihara M, Ito H, Yamamoto T, Tomimoto H, Takahashi R
    • Organizer
      XVIIth International Congress of Neuropathology
    • Place of Presentation
      Salzburg, Austria
    • Data Source
      KAKENHI-PROJECT-21500336

  • [Presentation] Establishment of iPS cells from amyotrophic lateral sclerosis model mice.2010
    • Author(s)
      Komatsu, K., Inoue, H., Kondo, T., Kitaoka, S., Ichisaka, T., Takahashi, K., Yamanaka, S., Takahashi, R.
    • Organizer
      The 33rd Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2010-09-02
    • Data Source
      KAKENHI-PROJECT-21591079

  • [Presentation] Nonhypotensive Dose of Telmisartan Attenuates Cognitive Impairment Partiyally Due to Peroxisome Proliferator-Activated-γ Activation in Mice With Chronic Cerebral Hypoperfusion.2010
    • Author(s)
      Washida K, Ihara M, Nishio K, Fujita Y, Maki T, Yamada M, Takahashi J, Wu X, Kihara T, Ito H, Tomimoto H, Takahashi R.
    • Organizer
      The 1st Annual Neuroscience Conference
    • Place of Presentation
      Nairobi, Kenya
    • Year and Date
      2010-09-07
    • Data Source
      KAKENHI-PROJECT-20390383

  • [Presentation] Analysis of motor neurons derived from induced pluripotent stem cells from ALS patients.2010
    • Author(s)
      Kitaoka, S., Inoue, H., Tsukita, K., Kawada, M., Naitoh, M., Takahashi, K., Yoshikawa, K., Kondo, T., Yamawaki, S., Watanabe, D., Suzuki, S., Takahashi, R., Yamanaka, S.
    • Organizer
      The 40th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2010-11-17
    • Data Source
      KAKENHI-PROJECT-21591079

  • [Presentation] A high-throughput screening assay for drug discovery in SOD1-mediated ALS targeting the transcription of SOD12010
    • Author(s)
      Murakami G, Inoue H, Takahashi R
    • Organizer
      The 33rd Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Kobe, Japan.
    • Year and Date
      2010-09-03
    • Data Source
      KAKENHI-PROJECT-20390244

  • [Presentation] A high-throughput screening assay for drug discovery in SOD1-mediated ALS targeting the transcription of SOD12010
    • Author(s)
      Murakami G, Inoue H, Takahashi R
    • Organizer
      The 40th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      San Diego, U.S.A.
    • Year and Date
      2010-11-17
    • Data Source
      KAKENHI-PROJECT-20390244

  • [Presentation] Transcription-targeted drug discovery for SOD1-mediated ALS using high-throughput screening technique2010
    • Author(s)
      Murakami G, Inoue H, Tsukita K, Asai Y, Amagai Y, Aiba K, Uesugi M, Nakatsuji N, Takahashi R
    • Organizer
      The 40th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2010-11-17
    • Data Source
      KAKENHI-PROJECT-21591079

  • [Presentation] Clinical and Neuropathologic Investigation of a Family with ALS Associated with Mutated Optineurin2010
    • Author(s)
      Ito H, Nakamura M, Komure O, Maruyama M, Wate R, Nakamura Y, Fujita K, Kaneko S, Ogasawara O, Nakabayashi H, Ayaki T, Okamoto Y, Ihara M, Kaji R, Kusaka H, Hirano A, Takahashi R, Kawakami H
    • Organizer
      XVIIth International Congress of Neuropathology
    • Place of Presentation
      Salzburg, Austria
    • Data Source
      KAKENHI-PROJECT-21500336

  • [Presentation] パーキンソン病に対する幹細胞移植治療の開発研究2010
    • Author(s)
      高橋淳、五味正憲
    • Organizer
      神経組織の成長・再生・移植研究会第25回学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2010-05-22
    • Data Source
      KAKENHI-PROJECT-20390383

  • [Presentation] Differentiation of induced pluripotent stem cells from ALS patients generates motor neurons.2010
    • Author(s)
      Kitaoka, S., Inoue, H, Tsukita, K., Kawada, M., Naitoh, M., Takahashi, K., Yoshikawa, K., Kondo T., Yamawaki, S., Watanabe, D., Suzuki, S., Nakahata, T., Takahashi, R., Yamanaka, S.
    • Organizer
      The 33rd Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2010-09-02
    • Data Source
      KAKENHI-PROJECT-21591079

  • [Presentation] Cortical microinfarcts are related to cerebral amyloid angiopathy rather than to senile plaques or neurofibrillary tangles2010
    • Author(s)
      Okamoto Y, Ihara M, Ito H, Yamamoto T, Tomimoto H, Takahashi R
    • Organizer
      The 40th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Data Source
      KAKENHI-PROJECT-21500336

  • [Presentation] The establishment and analysis of 26S proteasome conditional knockout mice for the mechanisms of neurodegenerative diseases.2010
    • Author(s)
      Tashiro Y, Inoue H, Yamazaki M, Abe M, Ito H, Misawa H, Sakimura K, Takahashi R
    • Organizer
      BMB2010
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-08
    • Data Source
      KAKENHI-PROJECT-20390244

  • [Presentation] Analysis of motor neurons derived from induced pluripotent stem cells from ALS patients2010
    • Author(s)
      Kitaoka S, Inoue H, Tsukita K, Kawada M, Naitoh M, Takahashi K, Yoshikawa K, Kondo T, Yamawaki S, Watanabe D, Suzuki S, Takahashi R, Yamanaka S
    • Organizer
      The 40th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego, USA.
    • Year and Date
      2010-11-17
    • Data Source
      KAKENHI-PROJECT-21591079

  • [Presentation] Nonhypotensive Dose of Telmisartan Attenuates Cognitive Impairment Partiyally Due to Peroxisome Proliferator-Activated-γ Activation in Mice With Chronic Cerebral Hypoperfusion.2010
    • Author(s)
      Washida K, Ihara M, Nishio K, Fujita Y, Maki T, Yamada M, Takahashi J, Wu X, Kihara T, Ito H, Tomimoto H, Takahashi R.
    • Organizer
      The 33^<rd> Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Kobe
    • Year and Date
      2010-09-19
    • Data Source
      KAKENHI-PROJECT-20390383

  • [Presentation] Nonhypotensive Dose of Telmisartan Attenuates Cognitive Impariment Partially due to PPAR-γ Activation in Mice with Chronic Cerebral Hypoperfusion.2010
    • Author(s)
      Washida K, Ihara M, Nishio K, Fujita Y, Maki T, Yamada M, Takahashi J, Wu X, Kihara T, Ito H, Tomimoto H, Takahashi R.
    • Organizer
      The 35^<th> Japanese Congress of Stroke
    • Place of Presentation
      morioka
    • Year and Date
      2010-04-16
    • Data Source
      KAKENHI-PROJECT-20390383

  • [Presentation] Nonhypotensive Dose of Telmisartan Attenuates Cognitive Impariment Partially due to PPAR-γ Activation in Mice with Chronic Cerebral Hypoperfusion.2010
    • Author(s)
      Washida K, Ihara M, Nishio K, Fujita Y, Maki T, Yamada M, Takahashi J, Wu X, Kihara T, Ito H, Tomimoto H, Takahashi R.
    • Organizer
      The 51^<st> Annual Meeting of Japanese Society of Neurology
    • Place of Presentation
      Tokyo
    • Year and Date
      2010-05-20
    • Data Source
      KAKENHI-PROJECT-20390383

  • [Presentation] 神経変性疾患モデル作製のための26Sプロテアソームコンディショナルノックアウトマウスの確立と解析2010
    • Author(s)
      田代善崇、井上治久、山崎真弥、阿部学、伊東秀文、三澤日出巳、崎村建司、高橋良輔
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-03
    • Data Source
      KAKENHI-PROJECT-20390244

  • [Presentation] Nonhypotensive Dose of Telmisartan Attenuates Cognitive Impairment Partially Due to Peroxisome Proliferator-Activated-γ Activation in Mice With Chronic Cerebral Hypoperfusion.2010
    • Author(s)
      Washida K, Ihara M, Nishio K, Fujita Y, Maki T, Yamada M, Takahashi J, et al.
    • Organizer
      The 33^<rd> Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-19
    • Data Source
      KAKENHI-PROJECT-20390383

  • [Presentation] Nonhypotensive Dose of Telmisartan Attenuates Cognitive Impairment Partiyally Due to Peroxisome Proliferator-Activated-γ Activation in Mice With Chronic Cerebral Hypoperfusion.2010
    • Author(s)
      Washida K, Ihara M, Nishio K, Fujita Y, Maki T, Yamada M, Takahashi J, Wu X, Kihara T, Ito H, Tomimoto H, Takahashi R.
    • Organizer
      The 22^<nd> Annual Meeting of the Japanese Society of Cerebral Blood Flow and Metabolism
    • Place of Presentation