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Yamanaka Koji  山中 宏二

… Alternative Names

YAMANAKA Koji  山中 宏二

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Researcher Number 80446533
Other IDs
  • ORCIDhttps://orcid.org/0000-0003-4655-0035
Affiliation (Current) 2020: 名古屋大学, 環境医学研究所, 教授
Affiliation (based on the past Project Information) *help 2013 – 2020: 名古屋大学, 環境医学研究所, 教授
2011 – 2012: 独立行政法人理化学研究所, その他部局等, 研究員
2009 – 2012: The Institute of Physical and Chemical Research, 運動ニューロン変性研究チーム, チームリーダー
2007 – 2008: The Institute of Physical and Chemical Research, 山中研究ユニット, ユニットリーダー
2007: The Institute of Physical and Chemical Research, 山中研究ユニット, ユニットリーダー
Review Section/Research Field
Principal Investigator
Biological Sciences / Neurology / Basic Section 52020:Neurology-related / Medium-sized Section 52:General internal medicine and related fields
Except Principal Investigator
Biological Sciences / Neurology / Pharmacology in pharmacy / Complex Systems Disease Theory / Pathological medical chemistry / Bioorganic chemistry / Nerve anatomy/Neuropathology
Keywords
Principal Investigator
神経変性疾患 / 筋萎縮性側索硬化症 / グリア / 神経病態生化学 / ミクログリア / 神経炎症 / ALS / タンパク質分解 / グリア細胞 / 環境 … More / 脊髄環境 / 脊髄 / 細胞外環境 / アストロサイト / 免疫連関 / オルガネラゾーン / オルガネラ / ミトコンドリア / 小胞体 / モデル動物 / TBK1 / モデルマウス / 構造生物学 … More
Except Principal Investigator
筋萎縮性側索硬化症 / ミクログリア / 遺伝子 / アストロサイト / グリア / 運動ニューロン / 脳神経疾患 / 神経科学 / 改造学 / 蛋白質 / 解剖学 / マイクロアレイ / トランスクリプトーム / 自然免疫 / 神経変性疾患 / オステオポンチン / 細胞外マトリクス / 選択的脆弱性 / 神経変性 / NASH / マクロファージ / 慢性炎症 / 線維化 / MC4R / 非アルコール性脂肪肝炎 / 視床下部 / レプチン / 小胞体・ミトコンドリア膜間領域 / SOD1 / σ1受容体 / 抗酸化能 / プロオキシダント能 / 銅イオン還元能 / ヒドロキシルラジカル / スーパーオキシドディスムターゼ 1 / 蛋白質変性 / antioxidant / prooxidant / copper-induced oxidation / hydroxyl radical / superoxide dismutase / G6PDH / protein stability / 抗酸化 / プロオキシダント性 / 分子酸化 / ALS / SMA / スプライソソーム / TDP-43 / FUS / SMN / スプライシング / 脊髄性筋萎縮症 / RNA代謝異常 / RNA代謝 Less
  • Research Projects

    (18 results)
  • Research Products

    (185 results)
  • Co-Researchers

    (72 People)
  •  タンパク質の構造生物学に基づいた筋萎縮性側索硬化症の分子病態解明と治療法開発Principal InvestigatorOngoing

    • Principal Investigator
      山中 宏二
    • Project Period (FY)
      2019 – 2023
    • Research Category
      Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
    • Review Section
      Medium-sized Section 52:General internal medicine and related fields
    • Research Institution
      Nagoya University
  •  Identifying mechanisms of motor neuron degeneration through ER-mitochondria interactionPrincipal Investigator

    • Principal Investigator
      山中 宏二
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Research Institution
      Nagoya University
  •  TBK1遺伝子ネットワークから解明するALSの分子病態とその制御Principal InvestigatorOngoing

    • Principal Investigator
      山中 宏二
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52020:Neurology-related
    • Research Institution
      Nagoya University
  •  グリア・末梢免疫連関の制御を通じた神経変性機序の解明と治療標的同定Principal Investigator

    • Principal Investigator
      山中 宏二
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Nagoya University
  •  Role of the crosstalk between liver and brain in the pathophysiology of liver fibrosis

    • Principal Investigator
      Suganami Takayoshi
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Complex Systems Disease Theory
    • Research Institution
      Nagoya University
  •  Investigation on antioxidants with low pro-oxidant activity to stabilize proteins responsible for neurodegenerative disease.

    • Principal Investigator
      KUROKAWA Yoichi
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Bioorganic chemistry
    • Research Institution
      Fukui Prefectural University
  •  Elucidating pathomechanism of ALS through the abnormality in astrocytesPrincipal Investigator

    • Principal Investigator
      YAMANAKA Koji
    • Project Period (FY)
      2014 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      Nagoya University
  •  Cell-autonomous and non-cell-autonomous mechanisms of neurodegeneration in ALS

    • Principal Investigator
      Misawa Hidemi
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pharmacology in pharmacy
    • Research Institution
      Keio University
  •  Disruption of mitochondria-associated membrane in neurodegenerative disease

    • Principal Investigator
      Watanabe Seiji
    • Project Period (FY)
      2013 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Nagoya University
  •  Common defects of RNA metabolism in motor neuron diseases SMA and ALS

    • Principal Investigator
      Tsuiji Hitomi
    • Project Period (FY)
      2013 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      Nagoya City University
      Institute of Physical and Chemical Research
  •  Microarray analysis in spinal cords of sporadic ALS patients with cell-type specific transcriptome

    • Principal Investigator
      YAMASHITA Hirofumi
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Kyoto University
  •  神経-グリアネットワーク変調が来す運動神経変性機序の解明Principal Investigator

    • Principal Investigator
      山中 宏二
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      The Institute of Physical and Chemical Research
  •  Brain Environment

    • Principal Investigator
      Takahashi Ryosuke
    • Project Period (FY)
      2011 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  Spinal cord environment: elucidating the mechanism of neurodegeneration through glia-neuron interactionPrincipal Investigator

    • Principal Investigator
      Yamanaka Koji
    • Project Period (FY)
      2011 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Nagoya University
      The Institute of Physical and Chemical Research
  •  Elucidating molecular pathology of glial cells in amyotrophic lateral sclerosisPrincipal Investigator

    • Principal Investigator
      YAMANAKA Koji
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      The Institute of Physical and Chemical Research
  •  神経炎症の制御を標的とした筋萎縮性側索硬化症の治療法の開発Principal Investigator

    • Principal Investigator
      山中 宏二
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The Institute of Physical and Chemical Research
  •  神経変性疾患における病因遺伝子産物のユビキチン修飾と分解機構の解明Principal Investigator

    • Principal Investigator
      山中 宏二
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The Institute of Physical and Chemical Research
  •  A role of microglia in Amyotrophic Lateral SclerosisPrincipal Investigator

    • Principal Investigator
      YAMANAKA Koji
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      The Institute of Physical and Chemical Research

All 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation Book

  • [Book] Animal Biotechnology2014

    • Author(s)
      Hitomi Tsuiji and Koji Yamanaka
    • Total Pages
      18
    • Publisher
      Elsevier
    • Data Source
      KAKENHI-PROJECT-25430055
  • [Book] 遺伝子医学MOOK26 脳内環境ー維持機構と破綻がもたらす疾患研究2014

    • Author(s)
      小峯起、山中宏二
    • Publisher
      メディカルドゥ
    • Data Source
      KAKENHI-PROJECT-26293208
  • [Book] 実験医学別冊「臓器円環による生体恒常性のダイナミクス」2013

    • Author(s)
      山中宏二
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PLANNED-23111006
  • [Book] すべてがわかるALS・運動ニューロン疾患2013

    • Author(s)
      山中宏二、小峯起
    • Publisher
      中山書店
    • Data Source
      KAKENHI-PLANNED-23111006
  • [Book] Animal Biotechnology: Models in Discovery and Translation2013

    • Author(s)
      Tsuiji Hitomi, Yamanaka Koji
    • Publisher
      Elsevier
    • Data Source
      KAKENHI-PLANNED-23111006
  • [Journal Article] ALS-linked TDP-43M337V knock-in mice exhibit splicing deregulation without neurodegeneration2020

    • Author(s)
      Watanabe Seiji、Oiwa Kotaro、Murata Yuri、Komine Okiru、Sobue Akira、Endo Fumito、Takahashi Eiki、Yamanaka Koji
    • Journal Title

      Molecular Brain

      Volume: 13 Pages: 8-8

    • DOI

      10.1186/s13041-020-0550-4

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19KK0214, KAKENHI-PUBLICLY-18H04860, KAKENHI-PROJECT-18H02740, KAKENHI-PROJECT-17H04986, KAKENHI-PROJECT-19K21221
  • [Journal Article] 筋萎縮性側索硬化症におけるMAMの破綻.2019

    • Author(s)
      渡邊征爾,山中宏二
    • Journal Title

      実験医学増刊 ミトコンドリアと疾患・老化

      Volume: 37 Pages: 138-144

    • Data Source
      KAKENHI-PUBLICLY-18H04860
  • [Journal Article] Mice deficient in the C-terminal domain of TAR DNA-binding protein 43 develop age-dependent motor dysfunction associated with impaired Notch1?Akt signaling pathway2019

    • Author(s)
      Nishino Kohei、Watanabe Seiji、Shijie Jin、Murata Yuri、Oiwa Kotaro、Komine Okiru、Endo Fumito、Tsuiji Hitomi、Abe Manabu、Sakimura Kenji、Mishra Amit、Yamanaka Koji
    • Journal Title

      Acta Neuropathologica Communications

      Volume: 7 Pages: 118-118

    • DOI

      10.1186/s40478-019-0776-5

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K01972, KAKENHI-PUBLICLY-18H04860, KAKENHI-PROJECT-18H02540, KAKENHI-PROJECT-18H02740, KAKENHI-PROJECT-17H04986
  • [Journal Article] The multi-dimensional roles of astrocytes in ALS2018

    • Author(s)
      Yamanaka Koji、Komine Okiru
    • Journal Title

      Neuroscience Research

      Volume: 126 Pages: 31-38

    • DOI

      10.1016/j.neures.2017.09.011

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K14963, KAKENHI-PROJECT-26293208, KAKENHI-PUBLICLY-16H01336
  • [Journal Article] Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice withaccumulation of aberrantly activated astrocytes.2018

    • Author(s)
      Komine Okiru、Yamashita Hirofumi、Fujimori-Tonou Noriko、Koike Masato、Jin Shijie、Moriwaki Yasuhiro、Endo Fumito、Watanabe Seiji、Uematsu Satoshi、Akira Shizuo、Uchiyama Yasuo、Takahashi Ryosuke、Misawa Hidemi、Yamanaka Koji
    • Journal Title

      Cell Death Differ

      Volume: 印刷中 Pages: 2130-2146

    • DOI

      10.1038/s41418-018-0098-3

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08522, KAKENHI-PROJECT-26293208, KAKENHI-PUBLICLY-16H01336, KAKENHI-PUBLICLY-17H05698, KAKENHI-PROJECT-17H04257, KAKENHI-PROJECT-18H02571, KAKENHI-PROJECT-18H02740, KAKENHI-PROJECT-17H04986, KAKENHI-PROJECT-17K19543, KAKENHI-PROJECT-17K14963
  • [Journal Article] Phenotypic heterogeneity of astrocytes in motor neuron disease.2018

    • Author(s)
      Trias E, Barbeito L, Yamanaka K
    • Journal Title

      Clin Exp Neuroimmunol

      Volume: 9 Pages: 225-234

    • DOI

      10.1111/cen3.12476

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02740
  • [Journal Article] A copper-deficient form of mutant Cu/Zn- superoxide dismutase as an early pathological species in amyotrophic lateral sclerosis.2018

    • Author(s)
      Tokuda Eiichi、Nomura Takao、Ohara Shinji、Watanabe Seiji、Yamanaka Koji、Morisaki Yuta、Misawa Hidemi、Furukawa Yoshiaki
    • Journal Title

      Biochimica et Biophysica Acta -Molecular Basis of Disease.

      Volume: 印刷中 Pages: 2119-2130

    • DOI

      10.1016/j.bbadis.2018.03.015

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-17H05705, KAKENHI-PROJECT-16H04768, KAKENHI-PROJECT-16K16634, KAKENHI-PROJECT-18K05329, KAKENHI-PUBLICLY-18H04860, KAKENHI-PROJECT-17H04986, KAKENHI-PROJECT-17K15077
  • [Journal Article] Immunochemical characterization on pathological oligomers of mutant Cu/Zn-superoxide dismutase in amyotrophic lateral sclerosis.2017

    • Author(s)
      Eiichi Tokuda, Itsuki Anzai, Takao Nomura, Keisuke Toichi, Masahiko Watanabe, Shinji Ohara, Seiji Watanabe, Koji Yamanaka, Yuta Morisaki, Hidemi Misawa, and Yoshiaki Furukawa
    • Journal Title

      Molecular neurodegeneration

      Volume: 12 Pages: 2-2

    • DOI

      10.1186/s13024-016-0145-9

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PUBLICLY-15H01566, KAKENHI-PROJECT-16H04768, KAKENHI-PROJECT-26293208, KAKENHI-PROJECT-15K14480, KAKENHI-PROJECT-25860252
  • [Journal Article] Mahogunin ring finger 1 confers cytoprotection against mutant SOD1 aggresomes and is defective in an ALS mouse model.2016

    • Author(s)
      Chhangani D, Endo F, Amanullah A, Upadhyay A, Watanabe S, Mishra R, Yamanaka K, Mishra A
    • Journal Title

      Neurobiology of Disease

      Volume: 86 Pages: 16-16

    • DOI

      10.1016/j.nbd.2015.11.017

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25860252, KAKENHI-PLANNED-23111006, KAKENHI-PROJECT-26293208
  • [Journal Article] Neuregulin 1 confers neuroprotection in SOD1-linked amyotrophic lateral sclerosis mice via restoration of C-boutons of spinal motor neurons2016

    • Author(s)
      Lasiene J, Komine O, Fujimori-Tonou N, Powers B, Endo F, Watanabe S, Shijie J, Ravits J, Horner P, Misawa H, Yamanaka K
    • Journal Title

      Acta Neuropathol. Commun.

      Volume: 4 Pages: 15-15

    • DOI

      10.1186/s40478-016-0286-7

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25860252, KAKENHI-PROJECT-26830046, KAKENHI-PLANNED-23111006, KAKENHI-PROJECT-25293020, KAKENHI-PROJECT-26293208
  • [Journal Article] Neuroinflammation in motor neuron disease.2016

    • Author(s)
      Endo F, Komine O, Yamanaka K.
    • Journal Title

      Clinical and Experimental Neuroimmunology

      Volume: 7 Pages: 126-138

    • DOI

      10.1111/cen3.12309

    • NAID

      120005672307

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PUBLICLY-16H01336, KAKENHI-PROJECT-26293208, KAKENHI-PROJECT-16K09671
  • [Journal Article] Selective Expression of Osteopontin in ALS-resistant Motor Neurons is a Critical Determinant of Late Phase Neurodegeneration Mediated by Matrix Metalloproteinase-9.2016

    • Author(s)
      Morisaki Y, Niikura M, Watanabe M, Onishi K, Tanabe S, Moriwaki Y, Okuda T, Ohara S, Murayama S, Takao M, Uchida S, Yamanaka K, Misawa H.
    • Journal Title

      Sci Rep

      Volume: 6 Pages: 27354-27354

    • DOI

      10.1038/srep27354

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26293208, KAKENHI-PROJECT-15K21370, KAKENHI-PROJECT-16H06277
  • [Journal Article] Mitochondria-associated membrane collapse is a common pathomechanism in SIGMAR1- and SOD1-linked ALS2016

    • Author(s)
      Watanabe S, Ilieva H, Tamada H, Nomura H, Komine O, Endo F, Jin S, Mancias P, Kiyama H, *Yamanaka K.
    • Journal Title

      EMBO Mol Med

      Volume: 8 Pages: 1421-1421

    • DOI

      10.15252/emmm.201606403

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-16H01336, KAKENHI-PROJECT-16H05117, KAKENHI-PROJECT-26293208, KAKENHI-PROJECT-15K19321, KAKENHI-PROJECT-25860252, KAKENHI-PROJECT-26830046, KAKENHI-PROJECT-16K09671
  • [Journal Article] SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis.2015

    • Author(s)
      Watanabe S, Ageta-Ishihara N, Nagatsu S, Takao K, Komine O, Endo F, Miyakawa T, Misawa H, Takahashi R, Kinoshita M, Yamanaka K.
    • Journal Title

      Mol Brain.

      Volume: 7 Pages: 2532-2532

    • DOI

      10.1186/s13041-014-0062-1

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-221S0003, KAKENHI-PLANNED-23111006, KAKENHI-PUBLICLY-25116514, KAKENHI-PUBLICLY-25116526, KAKENHI-PROJECT-25293020, KAKENHI-PROJECT-25350989, KAKENHI-PROJECT-25860252, KAKENHI-PUBLICLY-26115529, KAKENHI-PROJECT-26293208, KAKENHI-PROJECT-26440095, KAKENHI-PLANNED-23111002, KAKENHI-PROJECT-25242078
  • [Journal Article] Astrocyte-derived TGF-β1 accelerates disease progression in ALS mice by interfering with the neuroprotective functions of microglia and T Cells.2015

    • Author(s)
      Endo F, Komine O, Fujimori-Tonou N, Katsuno M, Jin S, Watanabe S, Sobue G, Dezawa M, Wyss-Coray T, Yamanaka K
    • Journal Title

      Cell Rep

      Volume: 11 Pages: 592-604

    • DOI

      10.1016/j.celrep.2015.03.053

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25860252, KAKENHI-PROJECT-26830046, KAKENHI-ORGANIZER-23111001, KAKENHI-PROJECT-26670439, KAKENHI-PROJECT-26293206, KAKENHI-PROJECT-26293208, KAKENHI-PLANNED-26117002, KAKENHI-ORGANIZER-26117001
  • [Journal Article] Neuroinflammation in motor neuron disease.2015

    • Author(s)
      Komine O, Yamanaka K
    • Journal Title

      Nagoya Journal of Medical Science

      Volume: 77 Pages: 537-549

    • NAID

      120005672307

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-23111006
  • [Journal Article] Intranuclear aggregation of mutant FUS/TLS as a molecular pathomechanism of amyotrophic lateral sclerosis.2014

    • Author(s)
      Nomura, T., Watanabe, S., Kaneko, K., Yamanaka, K., Nukina, N. & Furukawa, Y.
    • Journal Title

      The J ournal of Biological Chemistry

      Volume: 289 Pages: 1192-1202

    • DOI

      10.1074/jbc.m113.516492

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-22110004, KAKENHI-PLANNED-23111006, KAKENHI-PUBLICLY-24111542, KAKENHI-PROJECT-24657093, KAKENHI-PROJECT-24659436, KAKENHI-PROJECT-25291028
  • [Journal Article] Disease causing mutants of TDP-43 nucleic acid binding domains are resistant to aggregation and have increased stability and half-life.2014

    • Author(s)
      AUSTIN James J., WRIGHT Gareth S., WATANABE Seiji, GROSSMANN Gunter, ANTONYUK Svetlana V., YAMANAKA Koji, HASNAIN S. Samar
    • Journal Title

      Proceedings of the National Academy of Sciences of the United States of America

      Volume: 111 Pages: 4309-4314

    • DOI

      10.1073/pnas.1317317111

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-23111006, KAKENHI-PROJECT-25860252
  • [Journal Article] Cystatin C protects neuronal cells against mutant copper-zinc superoxide dismutase-mediated toxicity.2014

    • Author(s)
      WATANABE Seiji, HAYAKAWA Tomoyo, Wakasugi Keisuke, YAMANAKA Koji
    • Journal Title

      Cell Death & Disease (Nature Publishing Group)

      Volume: 5

    • DOI

      10.1038/cddis.2014.459

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-23111006, KAKENHI-PROJECT-25860252, KAKENHI-PROJECT-26293208, KAKENHI-PROJECT-26440047
  • [Journal Article] Intracellular seeded aggregation of mutant Cu,Zn-superoxide dismutase associated with amyotrophic lateral sclerosis.2013

    • Author(s)
      Furukawa, Y., Kaneko, K., Watanabe, S., Yamanaka, K. & Nukina, N.
    • Journal Title

      F EBS Letters

      Volume: 587 Pages: 2500-2505

    • DOI

      10.1016/j.febslet.2013.06.046

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-22110004, KAKENHI-PLANNED-23111006, KAKENHI-PUBLICLY-24111542, KAKENHI-PROJECT-24657093, KAKENHI-PROJECT-24659436, KAKENHI-PROJECT-25291028
  • [Journal Article] E6-AP association promotes SOD1 aggresomes degradation and suppresses toxicity.2013

    • Author(s)
      MISHRA Amit, MAHESHIWARI Megha, CHHANGANI Deepak, FUJIMORI-TONOU Noriko, ENDO Fumito, JOSHI A.Prakashi, JANA N.Ranjan, YAMANAKA Koji
    • Journal Title

      Neurobiology of Aging

      Volume: 34

    • DOI

      10.1016/j.neurobiolaging.2012.08.016

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PLANNED-23111006
  • [Journal Article] Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness2013

    • Author(s)
      Kondo, T., (他24名), Murakami, K., Irie, K., Klein, W. L., Mori, H., Asada, T., Takahashi, R., Iwata, N., Yamanaka, S., Inoue, H
    • Journal Title

      Cell Stem Cell.

      Volume: 12 Pages: 780-4

    • DOI

      10.1016/j.stem.2013.01.009

    • NAID

      120005231417

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21248015, KAKENHI-PLANNED-22129006, KAKENHI-ORGANIZER-23111001, KAKENHI-PLANNED-23111002, KAKENHI-PROJECT-23249049, KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-23592093, KAKENHI-PROJECT-24220009, KAKENHI-PROJECT-24500408, KAKENHI-PROJECT-24590040, KAKENHI-PROJECT-24700367, KAKENHI-PROJECT-24790260, KAKENHI-PROJECT-24790276, KAKENHI-PUBLICLY-25123709, KAKENHI-PROJECT-25290018, KAKENHI-PROJECT-25460341, KAKENHI-PUBLICLY-23110535, KAKENHI-PUBLICLY-23123510
  • [Journal Article] Loss of TDP-43 causes age-dependent progressive motor neuron degeneration.2013

    • Author(s)
      Iguchi Y
    • Journal Title

      Brain.

      Volume: 136 Pages: 1371-1382

    • DOI

      10.1093/brain/awt029

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22390175, KAKENHI-PROJECT-22590965, KAKENHI-ORGANIZER-23111001, KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-23659452, KAKENHI-PROJECT-25293020, KAKENHI-PLANNED-22110005
  • [Journal Article] ALS病態におけるグリアの役割2012

    • Author(s)
      山下博史,山中宏二
    • Journal Title

      脳21

      Volume: 15 Pages: 28-33

    • Data Source
      KAKENHI-PROJECT-21390274
  • [Journal Article] ALS病態におけるグリアの役割2012

    • Author(s)
      山下博史、山中宏二
    • Journal Title

      脳21

      Volume: 15 Pages: 28-33

    • Data Source
      KAKENHI-PLANNED-23111006
  • [Journal Article] Glial Cells in Amyotrophic Lateral Sclerosis2011

    • Author(s)
      Lasiene, J., Yamanaka, K.
    • Journal Title

      Neurology Research International

      Volume: 2011 Pages: 718987-718987

    • DOI

      10.1155/2011/718987

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-10F00518, KAKENHI-PUBLICLY-23110523
  • [Journal Article] Glial cells i n Amyotrophic Lateral Sclerosis2011

    • Author(s)
      Lasiene J., Yamanaka K
    • Journal Title

      Neurol Res Int 2011

      Pages: 718987-718987

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390274
  • [Journal Article] Glial cells i n Amyotrophic Lateral Sclerosis2011

    • Author(s)
      Takeuchi H., 他14名, Yamanaka K., S obue G., Mizuno T, Suzumura A
    • Journal Title

      PLoS ONE

      Volume: 6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390274
  • [Journal Article] ALS-SOD1の発症機序2011

    • Author(s)
      山下博史,山中宏二
    • Journal Title

      Clinical Neuroscience

      Volume: 29 Pages: 1044-1045

    • Data Source
      KAKENHI-PROJECT-21390274
  • [Journal Article] ALSの病態-非細胞自律性の神経細胞死2010

    • Author(s)
      山中宏二,遠藤史人
    • Journal Title

      医学のあゆみ

      Volume: 235 Pages: 241-245

    • Data Source
      KAKENHI-PROJECT-21390274
  • [Journal Article] 神経変性疾患における細胞死研究のパラダイムシフト2010

    • Author(s)
      山中宏二
    • Journal Title

      実験医学増刊

      Volume: 28 Pages: 1188-1194

    • Data Source
      KAKENHI-PROJECT-21390274
  • [Journal Article] Mutation-dependent poly morphism of Cu, Zn-superoxide dismuta se aggregates in the familial form of am yotrophic lateral sclerosis2010

    • Author(s)
      Furukawa Y., Kaneko K., Yamanaka K., Nukina N.
    • Journal Title

      J. Biol. Chem

      Volume: 285 Pages: 22221-22231

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390274
  • [Journal Article] Misf olded Mutant SOD1 Directly Inhibits V DAC1 Conductance in a Mouse Model of Inherited ALS2010

    • Author(s)
      Israelson A., 他4名, Yamanaka K., S hoshan-Barmatz V., Cleveland D. W.
    • Journal Title

      Neuron

      Volume: 67 Pages: 575-587

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390274
  • [Journal Article] 筋萎縮性側索硬化症とグリア細胞2009

    • Author(s)
      山中宏二
    • Journal Title

      Medical Science Digest

      Volume: 35 Pages: 262-263

    • Data Source
      KAKENHI-PROJECT-21390274
  • [Journal Article] Schwann cells expressing dismutase active mutant SOD1 unexpectedly slow disease progression in ALS mice2009

    • Author(s)
      Lobsiger C. S., 他4名, Yamanaka K., Cleveland D. W.
    • Journal Title

      Natl. Acad. Sci

      Volume: 106 Pages: 4465-4470

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390274
  • [Journal Article] ALSの今後の研究方向と可能性は2009

    • Author(s)
      山中宏二
    • Journal Title

      MB Medical Rehabilitation

      Volume: 113 Pages: 13-18

    • Data Source
      KAKENHI-PROJECT-21390274
  • [Journal Article] Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice2008

    • Author(s)
      Koji Yamanaka, et al.
    • Journal Title

      Proc. Natl. Acad. Sci. USA 105

      Pages: 7594-7599

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591021
  • [Journal Article] Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis.2008

    • Author(s)
      Koji Yamanaka, et. al.
    • Journal Title

      Nature Neuroscience (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591021
  • [Journal Article] Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis2008

    • Author(s)
      Yamanaka K, Chun SJ, Boillee S, Fujimori-Tonou N, Yamashita H, Gutmann DH, Misawa H, Takahashi R, & Cleveland DW.
    • Journal Title

      Nat. Neurosci. 11

      Pages: 251-253

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591021
  • [Journal Article] Mutant dynein (Loa) triggers proprioceptive axon loss that extends survival only in the SOD1 ALS model with highest motor neuron death2008

    • Author(s)
      Ilieva H, Yamanaka K, Malkmus S, et al.(7名中2番目)
    • Journal Title

      Proc. Natl. Acad. Sci., USA. 105

      Pages: 12599-12604

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591021
  • [Journal Article] Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice2008

    • Author(s)
      Yamanaka K, Boillee S, Roberts EA, et al.(8名中1番目)
    • Journal Title

      Proc. Natl. Acad. Sci., USA, 105

      Pages: 7594-7599

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591021
  • [Journal Article] Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis.2008

    • Author(s)
      Koji Yamanaka, et. al.
    • Journal Title

      Nature Neuroscience (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19044048
  • [Journal Article] Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice.2008

    • Author(s)
      Koji Yamanaka, et al.
    • Journal Title

      Proc. Natl. Acad. Sci. USA 105

      Pages: 7594-7599

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19044048
  • [Journal Article] Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice.2008

    • Author(s)
      Koji Yamanaka, et al.
    • Journal Title

      Proc. Natl. Acad. Sci. USA 105

      Pages: 7594-7599

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20023034
  • [Journal Article] ALSとミクログリア: 非細胞自律性の神経細胞死2007

    • Author(s)
      山中 宏二、山下 博史
    • Journal Title

      Brain and Nerve 59

      Pages: 1163-1170

    • Data Source
      KAKENHI-PROJECT-19591021
  • [Journal Article] ALSとミクログリア:非細胞自律性の神経細胞死2007

    • Author(s)
      山中 宏二
    • Journal Title

      Brain and Nerve 59

      Pages: 1163-1170

    • Data Source
      KAKENHI-PROJECT-19591021
  • [Journal Article] ALSとミクログリア: 非細胞自律性の神経細胞死2007

    • Author(s)
      山中 宏二
    • Journal Title

      Brain and Nerve 59

      Pages: 1163-1170

    • Data Source
      KAKENHI-PROJECT-19044048
  • [Presentation] The role of neuroinflammation in neurodegenerative diseases.2020

    • Author(s)
      Yamanaka K.
    • Organizer
      The 15th International Symposium on Geriatrics and Gerontology
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02740
  • [Presentation] Molecular pathomechanism of motor neuron disease.2020

    • Author(s)
      Yamanaka K
    • Organizer
      UK-Japan Neuroscience Symposium
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19KK0214
  • [Presentation] 神経変性疾患の治療標的としてのグリア細胞 (Overview: glia as therapeutic targets for neurodegenerative diseases.)2019

    • Author(s)
      山中宏二
    • Organizer
      第60回日本神経学会学術大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18H02740
  • [Presentation] Collapse of Mitochondria-associated membrane as common pathomechanism in familial ALS including SOD1 mutations.2019

    • Author(s)
      Yamanaka Koji.
    • Organizer
      Mini-Symposium "Metal in ALS"
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-18H04860
  • [Presentation] TDP-43 mutant lacking its C-terminal domain induces age-dependent motor dysfunction in mice.2019

    • Author(s)
      Watanabe S, Nishino K, Murata Y, Oiwa K, Yamanaka K.
    • Organizer
      30th International Symposium on ALS/MND
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19KK0214
  • [Presentation] 運動神経変性におけるオルガネラ連携の破綻2019

    • Author(s)
      山中宏二
    • Organizer
      第42回日本神経科学大会第62回日本神経化学会大会
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-18H04860
  • [Presentation] 運動ニューロン疾患における小胞体・ミトコンドリア膜間領域破綻の意義.2018

    • Author(s)
      山中宏二
    • Organizer
      第59回日本神経学会学術大会
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-18H04860
  • [Presentation] Identification of MAM disruption as a general pathological mechanism in ALS.2018

    • Author(s)
      渡邊征爾, 山中宏二
    • Organizer
      第40回日本生物学的精神医学会 第61回日本神経化学会大会 合同年会
    • Data Source
      KAKENHI-PUBLICLY-18H04860
  • [Presentation] 筋萎縮性側索硬化症における免疫・グリア連関2018

    • Author(s)
      山中宏二
    • Organizer
      第40回日本生物学的精神医学会 第61回日本神経化学会大会 合同年会シンポジウム.
    • Invited
    • Data Source
      KAKENHI-PROJECT-18H02740
  • [Presentation] 運動神経変性におけるグリア細胞・神経炎症の役割2017

    • Author(s)
      山中宏二
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)ワークショップ
    • Invited
    • Data Source
      KAKENHI-PROJECT-26293208
  • [Presentation] 免疫学的視点からみた神経変性疾患の分子病態2017

    • Author(s)
      山中宏二
    • Organizer
      第29回日本神経免疫学会学術集会シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-26293208
  • [Presentation] Innate immune adaptor TRIF slows disease progression of ALS mice by eliminating aberrantly activated astrocytes.2017

    • Author(s)
      Komine O, Yamashita H. Fujimori-Tonou N, Uematsu S, Akira S, Yamanaka K.
    • Organizer
      28th International symposium on ALS/MND
    • Data Source
      KAKENHI-PROJECT-26293208
  • [Presentation] ALSにおける細胞群特異性病態と治療への展開2017

    • Author(s)
      山中宏二
    • Organizer
      第39回日本生物学的精神医学会, 第47回日本神経精神薬理学会合同年会シンポジウム
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-16H01336
  • [Presentation] 免疫学的視点からみた神経変性疾患の分子病態.2017

    • Author(s)
      山中宏二
    • Organizer
      第29回日本神経免疫学会学術集会シンポジウム
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-16H01336
  • [Presentation] Innate immune adaptor TRIF slows disease progression of ALS mice by eliminating aberrantly activated astrocytes.2017

    • Author(s)
      Komine O, Yamashita H. Fujimori-Tonou N, Uematsu S, Akira S, Yamanaka K.
    • Organizer
      28th International symposium on ALS/MND
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-16H01336
  • [Presentation] ALSにおける細胞群特異性病態と治療への展開2017

    • Author(s)
      山中宏二
    • Organizer
      第39回日本生物学的精神医学会, 第47回日本神経精神薬理学会合同年会シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-26293208
  • [Presentation] 筋萎縮性側索硬化症におけるグリア細胞・神経炎症の役割2017

    • Author(s)
      山中宏二
    • Organizer
      千里ライフサイエンスセミナー, 神経変性疾患の最前線
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-16H01336
  • [Presentation] 筋萎縮性側索硬化症におけるグリア細胞・神経炎症の役割2017

    • Author(s)
      山中宏二
    • Organizer
      千里ライフサイエンスセミナー,神経変性疾患の最前線(グリア細胞と神経疾患)
    • Invited
    • Data Source
      KAKENHI-PROJECT-26293208
  • [Presentation] 運動神経変性におけるグリア細胞・神経炎症の役割2017

    • Author(s)
      山中宏二
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)ワークショップ
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-16H01336
  • [Presentation] Astrocyte-derived extracellular vesicles contribute to the propagation of pathogenic protein in ALS.2017

    • Author(s)
      Endo F, Yamanaka K
    • Organizer
      28th international Symposium on ALS/MND
    • Data Source
      KAKENHI-PROJECT-26293208
  • [Presentation] グリア細胞からみた神経変性疾患2016

    • Author(s)
      山中宏二
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-20
    • Invited
    • Data Source
      KAKENHI-PROJECT-26293208
  • [Presentation] In vivo and in vitro characterization of SOD1 in early stages of ALS as a precursor to insoluble aggregates.2016

    • Author(s)
      Tokuda E, Anzai I, Nomura T, Ohara S, Watanabe S, Yamanaka K, Morisaki Y, Misawa H, Furukawa Y.
    • Organizer
      The 27th International Symposium on ALS/MND
    • Place of Presentation
      アイルランド, ダブリン
    • Year and Date
      2016-12-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25860252
  • [Presentation] Interneuron degeneration in TDP-43 transgenic mice displaying impaired memory2016

    • Author(s)
      Hitomi Tsuiji, Ikuyo Inoue, Asako Furuya, Mari Takeuchi, Yuko Yamakage, Mitsuharu Hattori, Koji Yamanaka
    • Organizer
      第39回 日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-07-20
    • Data Source
      KAKENHI-PROJECT-25430055
  • [Presentation] Neuregulin 1 confers neuroprotection in SOD1-linked ALS mice via restoration of C-boutons of spinal motor neurons.2016

    • Author(s)
      Komine O, Lasiene J, Fujimori-Tonou N, Powers B, Endo F, Watanabe S, Jin S, Ravits J, Horner P, Misawa H, Yamanaka K.
    • Organizer
      The 27th International Symposium on ALS/MND
    • Place of Presentation
      アイルランド, ダブリン
    • Year and Date
      2016-12-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25860252
  • [Presentation] Disruption of Mitochondria-associated membrance is a common pathomechanism both in SOD1-and SIGMAR1-linked ALS.2016

    • Author(s)
      Watanabe S, Yamanaka K
    • Organizer
      The 27th International Symposium on ALS/MND
    • Place of Presentation
      アイルランド, ダブリン
    • Year and Date
      2016-12-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25860252
  • [Presentation] ALSにおける運動神経サブタイプ選択的脆弱性を規定するメカニズム2016

    • Author(s)
      森﨑祐太, 渡邉みずほ, 森脇康博, 山中宏二, 三澤日出巳
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜 (神奈川県・横浜市)
    • Year and Date
      2016-03-10
    • Data Source
      KAKENHI-PROJECT-25293020
  • [Presentation] Interneuron degeneration in TDP-43 transgenic mice displaying impaired memory2016

    • Author(s)
      Hitomi Tsuiji, Ikuyo Inoue, Asako Furuya, Mari Takeuchi, Yuko Yamakage, Mitsuharu Hattori, Koji Yamanaka
    • Organizer
      The 21st Annual Meeting of the RNA Society
    • Place of Presentation
      京都国際会館
    • Year and Date
      2016-06-28
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25430055
  • [Presentation] グリア細胞からみた神経変性疾患2016

    • Author(s)
      山中宏二
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-20
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-16H01336
  • [Presentation] Active role of neuroinflammation in motor neuron disease.2016

    • Author(s)
      Yamanaka Koji
    • Organizer
      The 2nd IMCR Symposium on Endocrine and Metabolism: International Frontiers in Homeostatic Regulation Research,
    • Place of Presentation
      群馬
    • Year and Date
      2016-11-10
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293208
  • [Presentation] The role of peripheral immune system in amyotrophic lateral sclerosis mice2016

    • Author(s)
      小峯 起、大沼周平、池田早織、山中宏二.
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-20
    • Data Source
      KAKENHI-PUBLICLY-16H01336
  • [Presentation] Disruption of mitochondria associated membrane in amyotrophic lateral sclerosis.2016

    • Author(s)
      Watanabe S, Yamanaka K
    • Organizer
      第6回生理学研究所・名古屋大学医学系研究科合同シンポジウム
    • Place of Presentation
      名古屋大学鶴舞キャンパス
    • Year and Date
      2016-09-24
    • Data Source
      KAKENHI-PROJECT-25860252
  • [Presentation] ALS病態における末梢免疫の役割2016

    • Author(s)
      大沼周平、小峯 起、山中宏二
    • Organizer
      第38回日本生物学的精神医学会・第59回日本神経化学会大会合同年会
    • Place of Presentation
      福岡
    • Year and Date
      2016-09-08
    • Data Source
      KAKENHI-PUBLICLY-16H01336
  • [Presentation] ミクログリア・単球系細胞と神経変性疾患.2016

    • Author(s)
      山中宏二
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台
    • Year and Date
      2016-09-26
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-16H01336
  • [Presentation] Dysregulation of TGF-β signaling facilitates motor neurodegeneration of ALS mice.2016

    • Author(s)
      遠藤史人、山中宏二
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-20
    • Data Source
      KAKENHI-PROJECT-26293208
  • [Presentation] Neuregulin 1 confers neuroprotection in SOD1-linked ALS mice via restoration of C-boutons of spinal motor neurons.2016

    • Author(s)
      Komine O, Lasiene J, Fujimori-Tonou N, Powers B, Endo F, Watanabe S, Jin S, Ravits J, Horner P, Misawa H, Yamanaka K.
    • Organizer
      The 27th International Symposium on ALS/MND
    • Place of Presentation
      ダブリン
    • Year and Date
      2016-12-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293208
  • [Presentation] Interneuron degeneration in TDP-43 transgenic mice displaying impaired memory2016

    • Author(s)
      Hitomi Tsuiji, Ikuyo Inoue, Asako Furuya, Mari Takeuchi, Yuko Yamakage, Mitsuharu Hattori, Koji Yamanaka
    • Organizer
      11th Brain Research Conference
    • Place of Presentation
      Paradise Point, San Diego, CA
    • Year and Date
      2016-11-10
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25430055
  • [Presentation] Active role of neuroinflammation in motor neuron disease2016

    • Author(s)
      Yamanaka Koji
    • Organizer
      The 2nd IMCR Symposium on Endocrine and Metabolism: International Frontiers in Homeostatic Regulation Research,
    • Place of Presentation
      群馬
    • Year and Date
      2016-11-10
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-16H01336
  • [Presentation] Dysregulation of neuronal TGF-β signaling contributes to neurodegeneration in mutant SOD1 mice.2016

    • Author(s)
      遠藤史人、宮﨑 朗、山中宏二
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸
    • Year and Date
      2016-05-18
    • Data Source
      KAKENHI-PROJECT-26293208
  • [Presentation] ALSモデルマウスにおける自然免疫TRIF経路の役割2015

    • Author(s)
      小峯 起、山下博史、藤森典子、森脇康博、三澤 日出巳、山中宏二
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-28
    • Data Source
      KAKENHI-PLANNED-23111006
  • [Presentation] Mahogunin ring finger 1 confers cytoprotection against mutant SOD1 and is defective in ALS mice. 26th International Symposium on ALS/MLD2015

    • Author(s)
      Chhangani D, Endo F, Amanullah A, Watanabe S, Mishra R, Mishra A, Yamanaka K
    • Organizer
      26th International Symposium on ALS/MLD
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2015-12-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25860252
  • [Presentation] The role of astrocyte-derived TGF-β in motor neuron disease.2015

    • Author(s)
      Yamanaka Koji
    • Organizer
      25th International Society for Neurochemistry Biennial Meeting, symposium
    • Place of Presentation
      ケアンズ、豪州
    • Year and Date
      2015-08-23
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293208
  • [Presentation] The active roles of glial cells in motor neuron disease.2015

    • Author(s)
      Yamanaka Koji
    • Organizer
      The10th Annual GEO-PD (Genetic Epidemiology of Parkinson’s Disease)
    • Place of Presentation
      東京
    • Year and Date
      2015-10-02
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293208
  • [Presentation] Pathomechanisms and therapeutic directions common to motor neuron diseases.2015

    • Author(s)
      山中 宏二
    • Organizer
      第56回日本神経学会学術大会 シンポジウム
    • Place of Presentation
      新潟
    • Year and Date
      2015-05-22
    • Invited
    • Data Source
      KAKENHI-PROJECT-26293208
  • [Presentation] アストロサイト由来TGF-β1はALSの疾患進行を規定する.2015

    • Author(s)
      遠藤史人、小峯 起、金 世杰、渡邊征爾、山中宏二
    • Organizer
      第27回 日本神経免疫学会学術集会
    • Place of Presentation
      長良川国際会議場
    • Year and Date
      2015-09-15
    • Data Source
      KAKENHI-PROJECT-25860252
  • [Presentation] The role of astrocyte-derived TGF-β in motor neuron disease.2015

    • Author(s)
      Yamanaka Koji
    • Organizer
      26th International Society for Neurochemistry Biennial Meeting
    • Place of Presentation
      ケアンズ、豪州
    • Year and Date
      2015-08-23
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-23111006
  • [Presentation] 筋萎縮性側索硬化症ALSを引き起こす変異型FUS/TLSの解析2015

    • Author(s)
      近藤佑多、古屋亜佐子、内匠透、山中宏二、築地仁美、服部光治
    • Organizer
      第61回日本薬学会東海支部総会・大会
    • Place of Presentation
      名古屋(愛知県)
    • Year and Date
      2015-07-04
    • Data Source
      KAKENHI-PROJECT-25430055
  • [Presentation] The role of innate immune TRIF pathway in amyotrophic lateral sclerosis.2015

    • Author(s)
      小峯起、山下博史、藤森典子、森脇康博、遠藤史人、渡邊征爾、金世杰、三澤日出巳、山中宏二
    • Organizer
      第5回名古屋大学医学系研究科・生理学研究所合同シンポジウム
    • Place of Presentation
      生理学研究所
    • Year and Date
      2015-09-19
    • Data Source
      KAKENHI-PROJECT-25860252
  • [Presentation] グリア細胞からみた運動神経変性機序2015

    • Author(s)
      山中宏二
    • Organizer
      第34回日本認知症学会学術集会 シンポジウム
    • Place of Presentation
      青森
    • Year and Date
      2015-10-03
    • Invited
    • Data Source
      KAKENHI-PLANNED-23111006
  • [Presentation] Sigma 1 receptor deficiency is involved in motor neuronal degeneration through calcium deregulation at mitochondria-associated membrane.2015

    • Author(s)
      渡邊征爾、山中宏二
    • Organizer
      第58回 日本神経化学会大会
    • Place of Presentation
      大宮ソニックシティ
    • Year and Date
      2015-09-11
    • Data Source
      KAKENHI-PROJECT-25860252
  • [Presentation] Roles of osteopontin and matrix metalloproteinase-9 in the subtype-selective motor neuron vulnerability in ALS2015

    • Author(s)
      Morisaki Y, Tsubota A, Watanabe M, Moriwaki Y, Yamanaka K, Misawa H
    • Organizer
      The 45th Annual Meeting, Society for Neuroscience
    • Place of Presentation
      Chicago (USA)
    • Year and Date
      2015-10-18
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25293020
  • [Presentation] 運動ニューロンサブタイプの選択的脆弱性におけるオステオポンチンとマトリックスメタロプロテアーゼ-9の役割2015

    • Author(s)
      森﨑祐太、坪田充司、森脇康博、山中宏二、三澤日出巳
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸コンベンションセンター (兵庫県・神戸市)
    • Year and Date
      2015-07-28
    • Data Source
      KAKENHI-PROJECT-25293020
  • [Presentation] Astrocyte-derived TGF-β1 accelerates disease progression in ALS mice by regulating the neuroprotective inflammatory response of microglia and T cells.2015

    • Author(s)
      山中宏二、遠藤史人、小峯起、金世杰、渡邊征爾
    • Organizer
      第58回 日本神経化学会大会
    • Place of Presentation
      大宮ソニックシティ
    • Year and Date
      2015-09-11
    • Data Source
      KAKENHI-PROJECT-25860252
  • [Presentation] The active roles of glial cells in motor neuron disease.2015

    • Author(s)
      Yamanaka Koji
    • Organizer
      The10th Annual GEO-PD(Genetic Epidemiology of Parkinson’s Disease).
    • Place of Presentation
      東京
    • Year and Date
      2015-10-02
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-23111006
  • [Presentation] 前頭側頭葉変性症モデルマウスの脳の組織学的な解析2015

    • Author(s)
      竹内真理、山中宏二、築地仁美、服部光治
    • Organizer
      日本病院薬剤師会東海ブロック日本薬学会東海支部
    • Place of Presentation
      名古屋(愛知県)
    • Year and Date
      2015-11-01
    • Data Source
      KAKENHI-PROJECT-25430055
  • [Presentation] 運動ニューロンのサブタイプ選択的脆弱性におけるオステオポンチンとマトリックスメタロプロテアーゼ-9の役割2015

    • Author(s)
      森崎祐太、坪田充司、森脇康博、山中宏二、三澤日出巳
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-28
    • Data Source
      KAKENHI-PLANNED-23111006
  • [Presentation] Interneuron degeneration in TDP-43 transgenic mice displaying impaired memory2015

    • Author(s)
      Hitomi Tsuiji, Ikuyo Inoue, Asako Furuya, Mitsuharu Hattori, Koji Yamanaka
    • Organizer
      10th Brain Research Conference
    • Place of Presentation
      シカゴ(アメリカ)
    • Year and Date
      2015-10-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25430055
  • [Presentation] グリア細胞からみた運動神経変性機序2015

    • Author(s)
      山中 宏二
    • Organizer
      第34回日本認知症学会学術集会
    • Place of Presentation
      青森
    • Year and Date
      2015-10-03
    • Invited
    • Data Source
      KAKENHI-PROJECT-26293208
  • [Presentation] Pathomechanisms and therapeutic directions common to motor neuron diseases.2015

    • Author(s)
      山中宏二
    • Organizer
      第56回日本神経学会学術大会 シンポジウム
    • Place of Presentation
      新潟
    • Year and Date
      2015-05-22
    • Invited
    • Data Source
      KAKENHI-PLANNED-23111006
  • [Presentation] Calcium deregulation atmitochondria-associated membrane is important for motor neuronal degeneration in amyotrophic lateral sclerosis.2015

    • Author(s)
      Watanabe S, Yamanaka K
    • Organizer
      BMB2015(第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-25860252
  • [Presentation] Microarray analysis in spinal cords of sporadic ALS patients with cell-type specific transcriptome2014

    • Author(s)
      Hirofumi Yamashita, Okiru komine, Noriko Fujimori, Hidefumi Ito, Yohei Iguchi, Naoki Atsuta, Fumiaki Tanaka, Gen Sobue, Ryosuke Takahashi, Koji Yamanaka
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-13
    • Data Source
      KAKENHI-PROJECT-24591259
  • [Presentation] 筋萎縮性側索硬化症における神経炎症2014

    • Author(s)
      遠藤史人、山中宏二
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2014-05-24
    • Invited
    • Data Source
      KAKENHI-PROJECT-26293208
  • [Presentation] オステオポンチンはマウス脊髄におけるアルファー運動ニューロンサブタイプの新規マーカーである2014

    • Author(s)
      森﨑 祐太、坪田 充司、森脇 康博、奥田 隆志、山中宏二、三澤 日出巳.
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-09-11
    • Data Source
      KAKENHI-PROJECT-25293020
  • [Presentation] Microarray analysis in spinal cords of sporadic ALS patients with cell-type specific transcriptome2014

    • Author(s)
      Hirofumi Yamashita, Noriko Fujimori, Hidefumi Ito, Yohei Iguchi, Naoki Atsuta, Fumiaki Tanaka, Gen Sobue, Ryosuke Takahashi, Koji Yamanaka
    • Organizer
      Nucleic Acid Summit
    • Place of Presentation
      San Diego
    • Year and Date
      2014-06-19
    • Data Source
      KAKENHI-ORGANIZER-23111001
  • [Presentation] Microarray analysis in spinal cords of sporadic ALS patients with cell-type specific transcriptome2014

    • Author(s)
      Hirofumi Yamashita 、 Noriko Fujimori 、 Hidefumi Ito 、Yohei Iguchi 、Naoki Atsuta 、 Fumiaki Tanaka 、Gen Sobue 、 Ryosuke Takahashi 、Koji Yamanaka
    • Organizer
      Nucleic Acid Summit
    • Place of Presentation
      San Diego,U.S.A.
    • Year and Date
      2014-06-19
    • Data Source
      KAKENHI-PROJECT-24591259
  • [Presentation] 神経変性疾患ALSにおける自然免疫機構の役割.2014

    • Author(s)
      山中宏二
    • Organizer
      第37回日本神経科学大会シンポジウム
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2014-09-12
    • Invited
    • Data Source
      KAKENHI-PLANNED-23111006
  • [Presentation] 筋萎縮性側索硬化症における運動ニューロン変性とオステオポンチンおよびマトリックスメタロプロテアーゼ-9の関連の検討2014

    • Author(s)
      森﨑祐太、坪田充司、森脇康博、山中宏二、三澤日出巳.
    • Organizer
      第131回日本薬理学会関東部会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-10-11
    • Data Source
      KAKENHI-PROJECT-25293020
  • [Presentation] オステオポンチンはマウス脊髄におけるアルファー運動ニューロンサブタイプの新規マーカーである2014

    • Author(s)
      森﨑 祐太、坪田 充司、森脇 康博、奥田 隆志、山中宏二、三澤 日出巳
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2014-09-11
    • Data Source
      KAKENHI-PLANNED-23111006
  • [Presentation] 筋萎縮性側索硬化症における神経炎症.2014

    • Author(s)
      遠藤史人、山中宏二
    • Organizer
      第55回日本神経学会学術大会シンポジウム
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2014-05-24
    • Invited
    • Data Source
      KAKENHI-PLANNED-23111006
  • [Presentation] 筋萎縮性側索硬化症における細胞群特異的病態の解明2014

    • Author(s)
      山中宏二
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2014-05-23
    • Invited
    • Data Source
      KAKENHI-PLANNED-23111006
  • [Presentation] Microarray analysis in spinal cords of sporadic ALS patients with cell-type specific transcriptome2014

    • Author(s)
      Hirofumi Yamashita, Okiru komine, Noriko Fujimori, Hidefumi Ito, Yohei Iguchi, Naoki Atsuta, Fumiaki Tanaka, Gen Sobue, Ryosuke Takahashi, Koji Yamanaka
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-09-13
    • Data Source
      KAKENHI-ORGANIZER-23111001
  • [Presentation] 筋萎縮性側索硬化症における細胞群特異的病態の解明2014

    • Author(s)
      山中宏二
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2014-05-23
    • Invited
    • Data Source
      KAKENHI-PROJECT-26293208
  • [Presentation] 筋萎縮性側索硬化症における浸潤免疫細胞の機能解明2014

    • Author(s)
      小峯 起、山下博史、藤森典子、森脇康博、三澤日出巳、山中宏二.
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-09-11
    • Data Source
      KAKENHI-PROJECT-25293020
  • [Presentation] Cell-type specific gene expression changes in TDP-43 transgenic mice displaying memory defect.2013

    • Author(s)
      Tsuiji H., Inoue I., Kataoka A., Furuya A., Yamanaka K.
    • Organizer
      RNA Biology in Neurological diseases
    • Place of Presentation
      カリフォルニア、米国
    • Data Source
      KAKENHI-PROJECT-25430055
  • [Presentation] 神経変性疾患モデルであるTDP-43トランスジェニックマウスにおけるTDP-43標的遺伝子の同定2013

    • Author(s)
      築地仁美、井上郁代、古屋亜佐子、山中宏二
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Data Source
      KAKENHI-PROJECT-25430055
  • [Presentation] 変異スーパーオキシドジスムターゼ1(SOD1)はSOD1(G93A)マウスにおいてミトコンドリア・小胞体膜間領域に蓄積する2013

    • Author(s)
      渡邊征爾, 山中宏二
    • Organizer
      Neuro2013(第36回 日本神経科学大会・第56回 日本神経化学会大会・第23回 日本神経回路学会大会 合同大会)
    • Place of Presentation
      国立京都国際会館
    • Data Source
      KAKENHI-PROJECT-25860252
  • [Presentation] Spliceosome integrity is defective in motor neuron disease ALS and SMA2013

    • Author(s)
      Tsuiji H., Iguchi Y., Furuya A., Kataoka A., Hatsuta H., Atsuta N., Tanaka F.Hashizume Y., Akatsu H., Murayama S., Sobue G., Yamanaka K.
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都国際会議場
    • Data Source
      KAKENHI-PROJECT-25430055
  • [Presentation] Cystatin C protected neuronal cells against mutant copper-zinc superoxide dismutase-mediated toxicity in vitro.2013

    • Author(s)
      Seiji Watanabe, Keisuke Wakasugi, Koji Yamanaka
    • Organizer
      24th International Symposium on ALS/MND
    • Place of Presentation
      Milan, Italy
    • Data Source
      KAKENHI-PROJECT-25860252
  • [Presentation] Spliceosome integrity is defective in motor neuron disease ALS and SMA.2013

    • Author(s)
      Tsuiji H., Iguchi Y., Furuya A., Murayama S., Sobue G., Yamanaka K.
    • Organizer
      RNA 2013 The 18th Annual Meeting of the RNA Society
    • Place of Presentation
      Davos, Switzerland
    • Data Source
      KAKENHI-PROJECT-25430055
  • [Presentation] Microarray analysis in spinal cords of sporadic ALS patients with cell-type specific transcriptome.2013

    • Author(s)
      Hirofumi Yamashita, Noriko Fujimori, Hidefumi Ito, Yohei Iguchi, Naoki Atsuta, Fumiaki Tanaka, Gen Sobue, Ryosuke Takahashi, Koji Yamanaka.
    • Organizer
      Neuro2013
    • Place of Presentation
      京都市
    • Year and Date
      2013-06-21
    • Data Source
      KAKENHI-ORGANIZER-23111001
  • [Presentation] The role of microglia-immune interaction in neurodegeneration of ALS mouse model.2013

    • Author(s)
      Koji Yamanaka
    • Organizer
      2013 conference of International Society for Neurochemistry
    • Place of Presentation
      Cancun(メキシコ)
    • Year and Date
      2013-04-22
    • Invited
    • Data Source
      KAKENHI-PLANNED-23111006
  • [Presentation] 中枢神経系に浸潤する免疫系細胞とグリア連関の神経変性病態への役割.2013

    • Author(s)
      山中宏二
    • Organizer
      第36 回日本神経科学大会
    • Place of Presentation
      京都国際会議場(京都)
    • Year and Date
      2013-06-20
    • Invited
    • Data Source
      KAKENHI-PLANNED-23111006
  • [Presentation] Glial cells in experimental models of ALS: from a view of glia-immune communication.2013

    • Author(s)
      Koji Yamanaka
    • Organizer
      3rd Venusberg meeting on Neuroinflammation
    • Place of Presentation
      Bonn, Germany
    • Year and Date
      2013-02-28
    • Invited
    • Data Source
      KAKENHI-PLANNED-23111006
  • [Presentation] Non-autonomous cell deathは、神経変性疾患の共通機構か?2012

    • Author(s)
      山中宏二
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Year and Date
      2012-05-23
    • Invited
    • Data Source
      KAKENHI-PLANNED-23111006
  • [Presentation] The role of glia-immune communication in Amyotrophic Lateral Sclerosis.2012

    • Author(s)
      Koji Yamanaka
    • Organizer
      2012 The Korean Society for Neurodegenerative Disease Symposium
    • Place of Presentation
      Seoul, Korea
    • Invited
    • Data Source
      KAKENHI-PLANNED-23111006
  • [Presentation] The roles of microglia and immune system in neurodegeneration of ALS.2012

    • Author(s)
      Koji Yamanaka
    • Organizer
      Neuro2012
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2012-09-18
    • Invited
    • Data Source
      KAKENHI-PLANNED-23111006
  • [Presentation] ALSにおけるグリア関連病態2011

    • Author(s)
      山中宏二
    • Organizer
      第52回日本神経学会学術大会シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2011-05-20
    • Data Source
      KAKENHI-PROJECT-21390274
  • [Presentation] Active roles of glial cells in non-cell autonomous neurodegeneration in ALS2011

    • Author(s)
      Yamanaka K.
    • Organizer
      第34回日本神経科学大会シンポジウム
    • Place of Presentation
      横浜(招待講演)
    • Year and Date
      2011-09-15
    • Data Source
      KAKENHI-PLANNED-23111006
  • [Presentation] ALSにおけるグリア関連病態2011

    • Author(s)
      山中宏二
    • Organizer
      第52回日本神経学会学術大会シンポジウム
    • Place of Presentation
      名古屋(招待講演)
    • Year and Date
      2011-05-20
    • Data Source
      KAKENHI-PROJECT-21390274
  • [Presentation] The active role of glial cells in familial and sporadic motor neuron disease2011

    • Author(s)
      Yamanaka K
    • Organizer
      The 9th Biennial Conference of the Chinese Neuroscience Society
    • Place of Presentation
      Zhengzhou, China
    • Year and Date
      2011-08-01
    • Data Source
      KAKENHI-PROJECT-21390274
  • [Presentation] Recent advances in motor neuron disease : from modeling disease in laboratory animals to understanding human neurodegenerative disease2011

    • Author(s)
      Yamanaka K.
    • Organizer
      2011 KALAS (Korea Association for Laboratory Animal Science) International Symposium
    • Place of Presentation
      Muju, Korea(招待講演)
    • Year and Date
      2011-08-25
    • Data Source
      KAKENHI-PLANNED-23111006
  • [Presentation] The active role of glial cells in familial and sporadic motor neuron disease2011

    • Author(s)
      Yamanaka K
    • Organizer
      The 9th Biennial Conference of the Chinese Neuroscience Society
    • Place of Presentation
      Zhengzhou, China(招待講演)
    • Year and Date
      2011-08-01
    • Data Source
      KAKENHI-PROJECT-21390274
  • [Presentation] ALSにおけるグリア関連病態2011

    • Author(s)
      山中宏二
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋(シンポジウム)
    • Year and Date
      2011-05-20
    • Data Source
      KAKENHI-PUBLICLY-23110523
  • [Presentation] Elimination of innate immune system adaptor TRIF significantly accelerates disease progression of ALS mice2011

    • Author(s)
      Yamanaka K, et al, 他2名
    • Organizer
      22nd International Symposium on ALS/MND
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2011-11-30
    • Data Source
      KAKENHI-PLANNED-23111006
  • [Presentation] 神経変性疾患における非細胞自律性の神経細胞死, BMB20102010

    • Author(s)
      山中宏二
    • Organizer
      (第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)ワークショップ
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-09
    • Data Source
      KAKENHI-PROJECT-21390274
  • [Presentation] Active roles of glial cells in neurodegenerative disease2010

    • Author(s)
      Yamanaka K
    • Organizer
      International Conference on Systems in Medicine and Biology
    • Place of Presentation
      Kharagpur, India
    • Year and Date
      2010-12-17
    • Data Source
      KAKENHI-PROJECT-21390274
  • [Presentation] The role of glial cells in ALS. Neuro20102010

    • Author(s)
      Yamanaka K
    • Organizer
      (第33回日本神経科学大会,日本神経化学会,合同大会)シンポジウム
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-03
    • Data Source
      KAKENHI-PROJECT-21390274
  • [Presentation] 神経変性疾患における非細胞自律性の神経細胞死2010

    • Author(s)
      山中宏二
    • Organizer
      BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)ワークショップ
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-09
    • Data Source
      KAKENHI-PROJECT-21390274
  • [Presentation] The role of glial cells in ALS.2010

    • Author(s)
      Yamanaka K.
    • Organizer
      Neuro2010(第33回日本神経科学大会,日本神経化学会,合同大会)シンポジウム
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-03
    • Data Source
      KAKENHI-PROJECT-21390274
  • [Presentation] Active roles of glial cells in neurodegenerative disease.2010

    • Author(s)
      Yamanaka K.
    • Organizer
      International Conference on Systems in Medicine and Biology
    • Place of Presentation
      Kharagpur, India
    • Year and Date
      2010-12-17
    • Data Source
      KAKENHI-PROJECT-21390274
  • [Presentation] Glial cells as central contributors to non-cell autonomous neurodegeneration in ALS2009

    • Author(s)
      山中宏二
    • Organizer
      The 3rd Korea-Japan Neuroscience Symposium
    • Place of Presentation
      釜山(韓国)
    • Year and Date
      2009-08-26
    • Data Source
      KAKENHI-PROJECT-21390274
  • [Presentation] Controlling neuroinflammation through glial cells are viable target for the therapy to slow neurodegeneration in ALS2009

    • Author(s)
      山中宏二
    • Organizer
      第32回日本神経科学会大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-18
    • Data Source
      KAKENHI-PROJECT-20023034
  • [Presentation] Controlling neuroinflammation through glial cells are viable target for the therapy to slow neurodegeneration in ALS2009

    • Author(s)
      Yamanaka K
    • Organizer
      第32回日本神経科学会大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-18
    • Data Source
      KAKENHI-PROJECT-21390274
  • [Presentation] Glial cells as central contributors to non-cell autonomous neurodegeneration in ALS2009

    • Author(s)
      Yamanaka K
    • Organizer
      The 3rd Korea-Japan Neuroscience Symposium
    • Place of Presentation
      釜山
    • Year and Date
      2009-08-26
    • Data Source
      KAKENHI-PROJECT-21390274
  • [Presentation] 細胞特異的トランスクリプトームを用いたALSマウス脊髄DNAマイクロアレイの解析2009

    • Author(s)
      山下博史, 山中宏二, 他
    • Organizer
      第50回日本神経学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2009-05-20
    • Data Source
      KAKENHI-PROJECT-20023034
  • [Presentation] 細胞特異的トランスクリプトームを用いたALSマウス脊髄DNAマイクロアレイの解析2009

    • Author(s)
      山下博史, 山中宏二, 他
    • Organizer
      第50回日本神経学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2009-05-20
    • Data Source
      KAKENHI-PROJECT-21390274
  • [Presentation] Glial cells as central contributors to non-cell autonomous neurodegeneration in ALS2009

    • Author(s)
      山中宏二
    • Organizer
      The 3rd Korea-Japan Neuroscience Symposium
    • Place of Presentation
      Busan, Korea
    • Year and Date
      2009-08-26
    • Data Source
      KAKENHI-PROJECT-20023034
  • [Presentation] Astrocytes and microglia determine disease progression in amyrotrohic lateral sclerosis.2008

    • Author(s)
      Koji Yamanaka
    • Organizer
      Cold Spring Harbor 2008 Meeting on Glia in Health & Disease
    • Place of Presentation
      Cold Spring Harbor, USA
    • Year and Date
      2008-07-20
    • Data Source
      KAKENHI-PROJECT-20023034
  • [Presentation] Glial cells as central contributors to non-cell autonomous neurodegeneration in ALS2008

    • Author(s)
      Yamanaka K.
    • Organizer
      BMB2008 (第81回日本生化学会,第31回日本分子生物学会合同大会) シンポジウム
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-09
    • Data Source
      KAKENHI-PROJECT-19591021
  • [Presentation] Astrocytes and microglia determine disease progression in amyotrohic lateral sclerosis2008

    • Author(s)
      Koji Yamanaka
    • Organizer
      Cold Spring Harbor 2008 Meeting on Glia in Health & Disease
    • Place of Presentation
      Cold Spring Harbor, USA
    • Year and Date
      2008-07-20
    • Data Source
      KAKENHI-PROJECT-19591021
  • [Presentation] Glial cells as central contributors to non-cell autonomous neurodegeneration in ALS2008

    • Author(s)
      Koji Yamanaka
    • Organizer
      BMB2008(第81回日本生化学会, 第31回日本分子生物学会合同大会)シンポジウム
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-09
    • Data Source
      KAKENHI-PROJECT-20023034
  • [Presentation] Glial cells as central contributors to non-cell autonomous neurodegener ation in ALS.2008

    • Author(s)
      Koji Yamanaka
    • Organizer
      BMB2008(第81回日本生化学会, 第31回日本分子生物学会合同大会)シンポジウム
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-09
    • Data Source
      KAKENHI-PROJECT-19591021
  • [Presentation] Astrocytes and microglia determine disease progression in amyotrohic lateral sclerosis2008

    • Author(s)
      Yamanaka K.
    • Organizer
      Cold Spring Harbor 2008 Meeting on Glia in Health & Disease.
    • Place of Presentation
      Cold Spring Harbor, USA
    • Year and Date
      2008-07-20
    • Data Source
      KAKENHI-PROJECT-19591021
  • [Presentation] 非細胞自律性の神経細胞死2007

    • Author(s)
      山中 宏二
    • Organizer
      第27回日本医学会総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2007-04-06
    • Data Source
      KAKENHI-PROJECT-19591021
  • [Presentation] Selective gene ablation of mutant SOD1 in mice identifies astrocytes as determinant of disease progression in ALS.2007

    • Author(s)
      Koji Yamanaka
    • Organizer
      Society for Neuroscience 2007
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2007-11-05
    • Data Source
      KAKENHI-PROJECT-19044048
  • [Presentation] Selective gene ablation of mutant SOD1 in mice identifies astrocytes as determinant of disease progression in ALS2007

    • Author(s)
      Yamanaka K.
    • Organizer
      Society for Neuroscience 2007
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2007-11-05
    • Data Source
      KAKENHI-PROJECT-19591021
  • [Presentation] 神経変性疾患の動物モデルー筋萎縮性側索硬化症2007

    • Author(s)
      山中 宏二
    • Organizer
      第48回日本神経学会総会 シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2007-05-18
    • Data Source
      KAKENHI-PROJECT-19591021
  • [Presentation] Selective gene ablation of mutant SOD1 in astrocytes significantly slows disease progression of ALS mice2007

    • Author(s)
      Yamanaka K.
    • Organizer
      18th International Symposium on ALS/MND,
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2007-12-02
    • Data Source
      KAKENHI-PROJECT-19591021
  • [Presentation] Selective gene ablation of mutant SOD1 in astrocytes significantly slows disease progression of ALS mice.2007

    • Author(s)
      Koji Yamanaka
    • Organizer
      18th International Symposium on ALS/MND
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2007-12-02
    • Data Source
      KAKENHI-PROJECT-19044048
  • [Presentation] 非細胞自律性の神経細胞死2007

    • Author(s)
      山中 宏二
    • Organizer
      第27回日本医学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2007-04-06
    • Data Source
      KAKENHI-PROJECT-19591021
  • [Presentation] 非細胞自律性の神経細胞死2007

    • Author(s)
      山中 宏二
    • Organizer
      第27回日本医学会総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2007-04-06
    • Data Source
      KAKENHI-PROJECT-19044048
  • [Presentation] 神経変性疾患の動物モデルー筋萎縮性側索硬化症2007

    • Author(s)
      山中 宏二
    • Organizer
      第48回日本神経学会総会 シンポジウム
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2007-05-18
    • Data Source
      KAKENHI-PROJECT-19044048
  • [Presentation] Selective gene ablation of mutant SOD1 in astrocytes significantly slows disease progression of ALS mice.2007

    • Author(s)
      Koji Yamanaka
    • Organizer
      18th Intemational Symposium on ALS/MND
    • Place of Presentation
      Toronto,Canada
    • Year and Date
      2007-12-02
    • Data Source
      KAKENHI-PROJECT-19591021
  • [Presentation] Selective gene ablation of mutant SOD1 in mice identifies astrocytes as terminant of disease profression in ALS.2007

    • Author(s)
      Koji Yamanaka
    • Organizer
      Society for Neuroscience 2007
    • Place of Presentation
      San Diego,USA
    • Year and Date
      2007-11-05
    • Data Source
      KAKENHI-PROJECT-19591021
  • [Presentation] 神経変性疾患の動物モデルー筋萎縮性側索硬化症2007

    • Author(s)
      山中 宏二
    • Organizer
      第48回日本神経学会総会シンポジウム
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2007-05-18
    • Data Source
      KAKENHI-PROJECT-19591021
  • [Presentation] 自然免疫TRIF経路遮断によってALS疾患の進行が顕著に加速する

    • Author(s)
      小峯起, 藤森典子, 山下博史, 森脇康博, 三澤日出巳, 山中宏二.
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都市
    • Data Source
      KAKENHI-PROJECT-25293020
  • [Presentation] Motor neuron-derived osteopontin is an aggravation factor in the disease onset of ALS mice

    • Author(s)
      Niikura M, Tanabe S, Moriwaki Y, Yamanaka K, Misawa H.
    • Organizer
      Neuroscience 2013
    • Place of Presentation
      San Diego, California
    • Data Source
      KAKENHI-PROJECT-25293020
  • [Presentation] 運動神経変性疾患に共通するスプライソソーム異常

    • Author(s)
      築地仁美、井口洋平、古屋亜佐子、片岡礼音、村山繁雄、祖父江元、山中宏二
    • Organizer
      第54回日本神経病理学会総会
    • Place of Presentation
      東京
    • Invited
    • Data Source
      KAKENHI-PROJECT-25430055
  • [Presentation] Coordinated activation of autophagy and Cathepsin-mediated proteolysis inhibition is essential for neuroprotection by Cystatin C against mutant SOD1-mediated toxicity.

    • Author(s)
      Watanabe S, Wakasugi K, Yamanaka K
    • Organizer
      25th International Symposium on ALS/MND
    • Place of Presentation
      Brussels, Belgium
    • Year and Date
      2014-12-05 – 2014-12-07
    • Data Source
      KAKENHI-PROJECT-25860252
  • [Presentation] Region-specific changes in gene expression in transgenic TDP-43 mouse displaying impaired memory

    • Author(s)
      Hitomi Tsuiji, Ikuyo Inoue, Asako Furuya, Koji Yamanaka
    • Organizer
      The Nineteenth Annual Meeting of the RNA Society
    • Place of Presentation
      ケベック、カナダ
    • Year and Date
      2014-06-03 – 2014-06-08
    • Data Source
      KAKENHI-PROJECT-25430055
  • [Presentation] 筋萎縮性側索硬化症モデルマウスにおけるアクアポリン4の発現変動

    • Author(s)
      岩崎愛里, 中田俊輔, 森脇康博, 奥田隆志, 山中宏二, 阿部陽一郎, 安井正人, 三澤日出巳.
    • Organizer
      日本薬学会 第134年会
    • Place of Presentation
      熊本市
    • Data Source
      KAKENHI-PROJECT-25293020
  • [Presentation] Osteopontin/CD44 pathway in a mouse model of amyotrophic lateral sclerosis

    • Author(s)
      大西晃輔, 森脇康博, 新倉麻己子, 森崎祐太, 山中宏二, 三澤日出巳.
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台市
    • Data Source
      KAKENHI-PROJECT-25293020
  • [Presentation] 変異SOD1由来の毒性に対するシスタチンCの神経細胞保護機構の解明

    • Author(s)
      渡邊征爾, 若杉桂輔, 山中宏二
    • Organizer
      第37回 日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Data Source
      KAKENHI-PROJECT-25860252
  • [Presentation] 神経変性疾患ALSにおける自然免疫機構の役割

    • Author(s)
      山中宏二
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2014-09-11 – 2014-09-13
    • Invited
    • Data Source
      KAKENHI-PROJECT-26293208
  • 1.  YAMASHITA Hirofumi (60402913)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 10 results
  • 2.  WATANABE Seiji (70633577)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 35 results
  • 3.  MISAWA Hidemi (80219617)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 19 results
  • 4.  Takumi Toru (00222092)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 5.  KUROKAWA Yoichi (40326088)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  Takahashi Ryosuke (90216771)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
  • 7.  KOMINE Okiru (00456211)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 13 results
  • 8.  ENDO Fumito (10713307)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 16 results
  • 9.  高橋 英機 (40446521)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 10.  WATANABE Shoji (80462745)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  Kiyama Hiroshi (00192021)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 12.  Higuchi Makoto (10373359)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  Uchiyama Yasuo (10049091)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  Hattori Nobutaka (80218510)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  Kawakami Hideshi (70253060)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  Urushitani Makoto (60332326)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  MORIWAKI Yasuhiro (00392150)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 18.  Suzumura Akio (50196896)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  Takeuchi Hideyuki (30362213)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  Suganami Takayoshi (50343752)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  OHIGASHI Hajime (80026583)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  KANO Kenji (10152828)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  IRIE Kazuhiro (00168535)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 24.  Tsuiji Hitomi (40455358)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 13 results
  • 25.  祖父江 顕 (80823343)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  FUJIMORI Noriko
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 27.  Itoh Michiko
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  TAKAO Keizo
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 29.  AGETA Natsumi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 30.  KATSUNO Masahisa
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 31.  WATANABE Hirohisa
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 32.  TANABE hiroki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 33.  NOMURA Takao
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 34.  MURAKAMI Kazuma
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 35.  ABE Kentaro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 36.  SATOSHI Hibino
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 37.  ASAI Masashi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 38.  OKITA Keisuke
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 39.  山中 智行
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 40.  貫名 信行
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 41.  古川 良明
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 42.  宮川 剛
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 43.  阿部 修
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 44.  高尾 昌樹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 45.  渡辺 雅彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 46.  石原 健
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 47.  高尾 英正
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 48.  伊佐 正
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 49.  饗場 篤
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 50.  高橋 淑子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 51.  木下 専
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 52.  山中 章弘
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 53.  森 郁恵
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 54.  祖父江 元
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 55.  LASIENE JURATE
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 56.  小林 千浩
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 57.  戸田 達史
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 58.  渡辺 大
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 59.  八幡 直樹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 60.  近藤 隆一郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 61.  丸山 敬
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 62.  森 満
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 63.  渡辺 能行
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 64.  村山 繁雄
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 65.  渡辺 俊樹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 66.  小池 正人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 67.  植松 智
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 68.  若杉 桂輔
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 69.  阿部 学
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 70.  崎村 建司
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 71.  玉田 宏美
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 72.  徳田 栄一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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