IRIE Kazuhiro 入江一浩

Researcher Number	00168535
Other IDs
Affiliation (Current)	2025: 同志社大学, 研究開発推進機構, 嘱託研究員
Affiliation (based on the past Project Information) *help	2024 – 2025: 同志社大学, 研究開発推進機構, 嘱託研究員 2015 – 2023: 京都大学, 農学研究科, 教授 2016: 京都大学, (連合)農学研究科, 教授 2011 – 2016: 京都大学, (連合)農学研究科(研究院), 教授 2014: 京都大学, 大学院農学研究科, 教授 … More 2012: 京都大学, 大学院・農学研究科, 教授 2007 – 2011: Kyoto University, 農学研究科, 教授 2008: Kyoto University, 大学院・農学研究科, 教授 1999 – 2006: 京都大学, 農学研究科, 助教授 1997: Kyoto University, Graduate School of Agriculture, Division of Applied Life Sciences, Instructor, 農学研究科, 助手 1996: 京都大学, 農学研究家, 助手 1991 – 1996: 京都大学, 農学部, 助手 Less
Review Section/Research Field	Principal Investigator Bioproduction chemistry/Bioorganic chemistry / Bioproduction chemistry/Bioorganic chemistry / Science and Engineering / Medium-sized Section 38:Agricultural chemistry and related fields / Science and Engineering / Medium-sized Section 37:Biomolecular chemistry and related fields / Chemical biology / Bioorganic chemistry / Living organism molecular science Except Principal Investigator Bioproduction chemistry/Bioorganic chemistry … More / Science and Engineering / Basic Section 37020:Chemistry and chemical methodology of biomolecules-related / Bioorganic chemistry / 製造化学・食品 / Living organism molecular science / Biological Sciences Less
Keywords	Principal Investigator プロテインキナーゼC / ホルボールエステル / 発がんプロモーター / アルツハイマー病 / インドラクタム / Aβ42 / アルツハイマー / 凝集 / 光アフィニティーラベリング / 発癌プロモーター … More / 有機化学 / アミロイドβ / βアミロイド / Alzheimer's disease / β-sheet / 毒性オリゴマー / プロテインキナーゼＣ / アプリシアトキシン / オリゴマー / 抗体 / DARR / テレオシジン / 抗毒性ターン特異抗体 / aggregation / turn / amyloid / ターン / ベータシート / protein kinase C / tumor promoter / 脳神経疾患 / 発がん促進物質 / シグナル伝達 / がん細胞増殖抑制 / ブリオスタチン / フラボノイド / 毒性ターン / teleocidin / タキシフォリン / β-シート / 固体NMR / C1ドメイン / π相互作用 / CH / 亜鉛フィンガー / システインリッチドメイン / コンフォメーション / ジアゾアセチル基 / フォルボールエステル / toxic conformation / ganglioside / amyloid beta / 毒性配座特異抗体 / 抗毒性ターン抗体 / 毒性立体配座 / ジスルフィド結合 / 分子内ジスルフィド結合 / 抗Aβ42毒性配座特異抗体 / ２量体 / ジスルフィド架橋 / 分子内ジスルフィド架橋 / ヒト免疫不全ウイルス / マクラマイシン / CH/π相互作用 / 酵素 / 薬理学 / 癌 / HIV / アロタケタール / 機械学習 / solid-state NMR / familial Alzheimer's disease / Aβ1-42 / 家族性アルツハイマー病 / β-turn / 家族性アルツハイマー / アミロイド / zinc finger / phorbol / cysteine-rich domain / HATU / エレクトロスプレー質量分析法 / 固相合成 / conformation / indolactam / aza-Claisen rearrangement / アザクライゼン転位 / 神経細胞毒性 / ノックインマウス / 核酸アプタマー / 診断 / 脳脊髄液 / Epstein-Barrウィルス / ラン藻 / フサコケムシ / 珪藻 / 海綿 / がん / 海洋天然物 / TPA / 発がん2段階試験 / 細胞増殖抑制活性 / aplysiatoxin / がん細胞 / 増殖抑制 / ヒトがん細胞 / 発がん促進 / phorbol ester / bryostatin / debromoaplysiatoxin / 抗がん剤 / アプログ / 毒性コンホマー / 抗ターン抗体 / シナプス毒性 / クルクミン / カテコール / 凝集抑制 / Streptomyces / P450 / NRPS / 生合成 / indolactam-V / スピンラベル / シリマリン / βシート / R2 / β-シ-ト / アルツハイマ-病 / ESR / Aβ抗体 / ベンゾラクタム / カドミウム / 亜鉛放出 / エレクトロスプレー質量分析計 / ジアシルグリセロールキナーゼ / コンホメーション / ジアジリン / ポルフィリン / 光物理化学療法 / 光細胞毒性 / フラーレン / EBウイルス / アザ・コープ転位 … More Except Principal Investigator インドラクタム / 天然物化学 / ケミカルバイオロジー / アルツハイマー病 / シナプス受容体のモジュレーター / シナプス受容体モジュレーター / 化学合成 / ミミック / ドラッグデリバリーシステム / ペプチド / ポリアミン / 生物活性リガンド / 分子社会学 / 化学コミュニケーション / 分子酸化 / プロオキシダント性 / 抗酸化 / protein stability / G6PDH / superoxide dismutase / hydroxyl radical / copper-induced oxidation / prooxidant / antioxidant / 蛋白質変性 / スーパーオキシドディスムターゼ 1 / ヒドロキシルラジカル / 銅イオン還元能 / プロオキシダント能 / 抗酸化能 / tumor promoter / protein kinase C / phorbol ester / indolactam / diacylglycerol kinase / C1 domain / bryostatin / aplysiatoxin / indolactam-V / Unc13 / chimaerin / RasGRP / GFP / プロテインキナーゼC / C1ドメイン / 亜鉛フィンガー / ホルボールエステル / プロテインキナーゼ C / ブライオスタチン / 発がんプロモーター / C1 ドメイン / ジアシルグリセロールキナーゼ / アプリシアトキシン / Microbial conversion / Cyclization enzyme / Biosynthesis / Tumor promoter / Teleocidin / (-)-Indolactam-V / 発癌プロモ-タ- / 閉環酵素 / 微生物転換 / 生合成 / 発癌プロモーター / テレオシジン / タンパク質 / 有機合成 / 糖 / 蛋白質 / 生理活性 / プロポリス / 記憶障害改善 / フェニルエタノイド配糖体 / カフェオイルキナ酸 / HGF / ビスフラボノイド / 地骨皮 / キノコ / アルツハイマー症 / Aβ凝集阻害活性 / 神経細胞保護作用 / コーヒー / サツマイモ / HGF産生促進活性 / カフェ酸誘導体 / Th-T / アミロイドβ凝集阻害活性 / 分子設計 / 天然物ケミカルバイオロジー / 国際研究者交流（韓国） / 国際研究者交流（中国） / 国際研究者交流（米国） / 異分野融合 / 国際交流（スウェーデン） / 国際交流（韓国） / 国際交流（米国） / 国際交流（ドイツ） / 天然物リガンド / 標的同定 / 天然物 / ターン形成 / 電子スピン共鳴法 / ラジカル / 酸化ストレス / 凝集 / βアミロイド / Aβ42 Less

Development of inhibitors for the toxic oligomer formation based on the binding mode of amyloid beta and gangliosidePrincipal Investigator
- Principal Investigator
  
  入江一浩
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  Doshisha University
Development to ultra-early diagnosis and prevention of AD by using a specific antibody against the toxic conformation of amyloid betaPrincipal Investigator
- Principal Investigator
  
  入江一浩
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  Doshisha University
  Kyoto University
細胞膜で多彩に機能する有機化合物の合成化学的開発
- Principal Investigator
  
  及川雅人
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  Yokohama City University
Very early diagnosis of Alzheimer's disease by the toxic oligomer specific antibody of amyloid betaPrincipal Investigator
- Principal Investigator
  
  Irie Kazuhiro
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 37:Biomolecular chemistry and related fields
- Research Institution
  Kyoto University
Unified comprehension of chemical communication by natural PKC ligands and development of new medicinal seedsPrincipal Investigator
- Principal Investigator
  
  Irie Kazuhiro
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  Kyoto University
Frontiers in Chemical Communications
- Principal Investigator
  
  Kakeya Hideaki
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  Kyoto University
Investigation on antioxidants with low pro-oxidant activity to stabilize proteins responsible for neurodegenerative disease.
- Principal Investigator
  
  KUROKAWA Yoichi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Fukui Prefectural University
Novel Preventive Strategy for Alzheimer's Disease Based on the Toxic Conformation Theory of Amyloid betaPrincipal Investigator
- Principal Investigator
  
  Irie Kazuhiro
- Project Period (FY)
  2014 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Kyoto University
アミロイドβの毒性配座理論に基づいたアルツハイマー病の新規診断法の開発Principal Investigator
- Principal Investigator
  
  入江一浩
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Chemical biology
- Research Institution
  Kyoto University
Search for Inhibitors of Amyloid beta Aggregation from Edible Plants and Their Mechanism
- Principal Investigator
  
  SHIGEMORI Hideyuki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  University of Tsukuba
A new strategy for designing mannose receptors based on enantiomers of protein domains.
- Principal Investigator
  
  NAKAGAWA Yu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Living organism molecular science
- Research Institution
  Nagoya University
  Institute of Physical and Chemical Research
Chemical biology using natural products
- Principal Investigator
  
  UEDA Minoru
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  Tohoku University
Development and mechanistic analysis of new PKC ligands as anti-cancer agentsPrincipal Investigator
- Principal Investigator
  
  IRIE Kazuhiro
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  Kyoto University
Search for novel PKC ligands as therapeutic seeds for intractable diseasesPrincipal Investigator
- Principal Investigator
  
  IRIE Kazuhiro
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Kyoto University
Development of medicinal seeds for Alzheimer's disease based on the structural analysis of toxic oligomers of amyloid betaPrincipal Investigator
- Principal Investigator
  
  IRIE Kazuhiro
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Kyoto University
インドール環4位への窒素原子導入酵素の触媒機構の解析と応用Principal Investigator
- Principal Investigator
  
  入江一浩
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Kyoto University
CH/π相互作用を利用したPKCアイソザイム選択的な薬剤開発Principal Investigator
- Principal Investigator
  
  入江一浩
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Kyoto University
Development of antibodies and aggregation inhibitors for amyloid β peptides based on the new aggregation modelPrincipal Investigator
- Principal Investigator
  
  IRIE Kazuhiro
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Kyoto University
アミロイドβ42凝集体のターン構造をエピトープとしたワクチン療法の開発
- Principal Investigator
  
  白澤卓二
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Metropolitan Institute of Gerontology
CH/π相互作用を利用したPKCδ選択的薬剤の創製Principal Investigator
- Principal Investigator
  
  入江一浩
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Kyoto University
Structural analysis of β-amyloid fibrils using solid-state NMRPrincipal Investigator
- Principal Investigator
  
  IRIE Kazuhiro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  KYOTO UNIVERSITY
質量分析法によるリガンド-レセプター相互作用の精密解析Principal Investigator
- Principal Investigator
  
  入江一浩
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Living organism molecular science
- Research Institution
  Kyoto University
Development of new agents that regulate cellular signal transduction
- Principal Investigator
  
  OHIGASHI Hajime
- Project Period (FY)
  2003 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  KYOTO UNIVERSITY
発がんプロモーションのメカニズム解明のための鍵化合物の開発と応用Principal Investigator
- Principal Investigator
  
  入江一浩
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Kyoto University
Elucidation of aggregation mechanism of Alzheimer's β-peptides and development of their aggregation inhibitorsPrincipal Investigator
- Principal Investigator
  
  IRIE Kazuhiro
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Kyoto University
発がんプロモーションのメカニズム解明のための鍵化合物の開発Principal Investigator
- Principal Investigator
  
  入江一浩
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Science and Engineering
- Research Institution
  Kyoto University
Synthesis and characterization of the regulatory domains of protein kinase CPrincipal Investigator
- Principal Investigator
  
  IRIE Kazuhiro
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  KYOTO UNIVERSITY
発癌プロモーターとプロテインキナーゼCとの結合様式の有機化学的解析Principal Investigator
- Principal Investigator
  
  入江一浩
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
Synthesis and PKC binding of conformationally restricted indolactams by aza-Claisen rearrangementPrincipal Investigator
- Principal Investigator
  
  IRIE Kazuhiro
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  KYOTO UNIVERSITY
発癌プロモーターとプロテインキナーゼCとの結合様式の有機化学的解析Principal Investigator
- Principal Investigator
  
  入江一浩
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
新規水溶性フラーレン誘導体の合成とフォトダイナミックアクションPrincipal Investigator
- Principal Investigator
  
  入江一浩
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Kyoto University
発癌プロモーターとプロテインキナーゼCとの結合様式の有機化学的解析Principal Investigator
- Principal Investigator
  
  入江一浩
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
立体配座を固定した発癌プロモーター・テレオシジン誘導体の合成と生物活性Principal Investigator
- Principal Investigator
  
  入江一浩
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Kyoto University
プロテインキナーゼCの光アフィニティーラベリングPrincipal Investigator
- Principal Investigator
  
  入江一浩
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Kyoto University
Character and Application of the Cyclization Enzyme at position 4 of an indole ring.
- Principal Investigator
  
  KOSHIMIZU Koichi
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  製造化学・食品
- Research Institution
  KYOTO UNIVERSITY

[Book] CSJ Current Review　生物活性分子のケミカルバイオロジー　標的同定と作用機構2015
- Author(s)
  入江一浩　他30名
- Publisher
  化学同人
- Data Source
  KAKENHI-PLANNED-23102011
[Book] 固体NMR およびESR によるアミロイド β の立体構造解析と毒性ターン構造特異抗体の開発, 遺伝子医学MOOK21 号「最新ペプチド合成技術とその創薬研究への応用」2012
- Author(s)
  村上一馬, 増田裕一, *入江一浩
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PROJECT-21248015
[Book] Identification of toxic conformation in Aβ42 aggregates using solid-state NMR2009
- Author(s)
  Y. Masuda, 他3名, K. Takegoshi, *K. Irie
- Publisher
  The Japanese Peptide Society
- Data Source
  KAKENHI-PROJECT-18208011
[Book] 'Malignant' conformation of Alzheimer's β peptide (Aβ42) through radical formation (H. Ishida and H. Mihara (Eds.))2006
- Author(s)
  K. Murakami, *K. Irie, 他3名, T. Shimizu, T. Shirasawa
- Publisher
  The Japanese Peptide Society
- Data Source
  KAKENHI-PROJECT-18208011
[Journal Article] Synthesis and applications of symmetric amino acid derivatives2024
- Author(s)
  Chihiro Tsukano, Ayumi Uchino, and Kazuhiro Irie
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 22 Issue: 3 Pages: 411-428
- DOI
  10.1039/d3ob01379k
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22KJ1961, KAKENHI-PLANNED-23H04888, KAKENHI-PROJECT-23H00325
[Journal Article] Synthesis of stereoisomeric simplified analogs of alotaketals toward elucidation of the structural requirements of protein kinase C isozyme-selective binding2023
- Author(s)
  Okuda Sogen, Tsukano Chihiro, Irie Kazuhiro
- Journal Title
  
  Organic Letters
  
  Volume: 25 Issue: 5 Pages: 805-809
- DOI
  10.1021/acs.orglett.2c04328
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-17H06405, KAKENHI-PLANNED-23H04888
[Journal Article] In vivo anti-cancer activity of 10-methyl-aplog-1, a simplified analog of aplysiatoxin, and its possible signaling pathway associated with G1 arrest2023
- Author(s)
  Hanaki Yusuke, Shikata Yuki, Kikumori Masayuki, Okamura Mutsumi, Dan Shingo, Imoto Masaya, Irie Kazuhiro
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 675 Pages: 19-25
- DOI
  10.1016/j.bbrc.2023.07.008
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-17H06405
[Journal Article] Detection of Dietary Chalcone and Flavonoid Metabolites in Mice Using UPLC-MS/MS and Their Modulatory Effects on Amyloid β Aggregation2023
- Author(s)
  Taniwa Kota, Murakami Kazuma, Sakaguchi Yoshiki, Izuo Naotaka, Hanaki Mizuho, Sampa Nobuaki, Kume Toshiaki, Shimizu Takahiko, Irie Kazuhiro
- Journal Title
  
  Journal of Agricultural and Food Chemistry
  
  Volume: 71 Issue: 39 Pages: 14289-14299
- DOI
  10.1021/acs.jafc.3c02598
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26221202, KAKENHI-PROJECT-22K19607
[Journal Article] アミロイドβの毒性配座理論に基づくオリゴマーモデルの合成と構造機能解析2023
- Author(s)
  入江一浩
- Journal Title
  
  医学のあゆみ
  
  Volume: 287 Pages: 685-691
- Data Source
  KAKENHI-PROJECT-23H00325
[Journal Article] Biological evaluation of a phosphate ester prodrug of 10-methyl-aplog-1, a simplified analog of aplysiatoxin, as a possible latency-reversing agent for HIV reactivation2023
- Author(s)
  Maki Jumpei, Hanaki Yusuke, Yanagita C. Ryo, Kikumori Masayuki, Kovba Anastasiia, Washizaki Ayaka, Tsukano Chihiro, Akari Hirofumi, Irie Kazuhiro
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 87 Issue: 12 Pages: 1453-1461
- DOI
  10.1093/bbb/zbad128
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-17H06405
[Journal Article] Visualization of Amyloid Oligomers in the Brain of Patients with Alzheimer’s Disease2023
- Author(s)
  Tooyama Ikuo、Kato Tomoko、Taguchi Hiroyasu、Kageyama Yusuke、Irie Kazuhiro、Hirahara Yukie、Yanagisawa Daijiro
- Journal Title
  
  ACTA HISTOCHEMICA ET CYTOCHEMICA
  
  Volume: 56 Issue: 6 Pages: 87-94
- DOI
  10.1267/ahc.23-00058
- ISSN
  0044-5991, 1347-5800
- Year and Date
  2023-12-28
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14689, KAKENHI-PROJECT-22K07370, KAKENHI-PROJECT-23H00325, KAKENHI-PROJECT-23K28411
[Journal Article] A simplified analog of debromoaplysiatoxin lacking the B-ring of spiroketal moiety retains protein kinase C-binding and antiproliferative activities2022
- Author(s)
  Sekido Tomoki, Yamamoto Kosuke, Yanagita C. Ryo, Kawanami Yasuhiro, Hanaki Yusuke, Irie Kazuhiro
- Journal Title
  
  Bioorganic and Medicinal Chemistry
  
  Volume: 73 Pages: 116988-116988
- DOI
  10.1016/j.bmc.2022.116988
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-17H06405
[Journal Article] AI and computational chemistry-accelerated development of an alotaketal analogue with conventional PKC selectivity2022
- Author(s)
  Maki Jumpei、Oshimura Asami、Tsukano Chihiro、Yanagita Ryo C、Saito Yutaka、Sakakibara Yasubumi、Irie Kazuhiro
- Journal Title
  
  Chemical Communications
  
  Volume: 58 Issue: 47 Pages: 6693-6696
- DOI
  10.1039/d2cc01759h
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-17H06405, KAKENHI-PROJECT-23K24946
[Journal Article] Oxa-Michael-based divergent synthesis of artificial glutamate analogs2022
- Author(s)
  Tsukamoto Shuntaro、Hlokoane Oriel、Miyako Kei、Irie Raku、Sakai Ryuichi、Oikawa Masato
- Journal Title
  
  RSC Advances
  
  Volume: 12 Issue: 34 Pages: 22175-22179
- DOI
  10.1039/d2ra03744k
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K23478
[Journal Article] Structure Optimization of the Toxic Conformation Model of Amyloid β42 by Intramolecular Disulfide Bond Formation2022
- Author(s)
  Matsushima Yuka、Irie Yumi、Kageyama Yusuke、Bellier Jean‐Pierre、Tooyama Ikuo、Maki Takahito、Kume Toshiaki、Yanagita Ryo C.、Irie Kazuhiro
- Journal Title
  
  ChemBioChem
  
  Volume: n/a Issue: 8
- DOI
  10.1002/cbic.202200029
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08853, KAKENHI-PROJECT-19H00921
[Journal Article] Synthesis and Characterization of Propeller- and Parallel-Type Full-Length Amyloid β40 Trimer Models2022
- Author(s)
  Uchino Ayumi、Irie Yumi、Tsukano Chihiro、Kawase Taiji、Hirose Kenji、Kageyama Yusuke、Tooyama Ikuo、Yanagita Ryo C.、Irie Kazuhiro
- Journal Title
  
  ACS Chemical Neuroscience
  
  Volume: 13 Issue: 16 Pages: 2517-2528
- DOI
  10.1021/acschemneuro.2c00363
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H00921, KAKENHI-PROJECT-22KJ1961
[Journal Article] Synthetic Studies on the Initially Proposed Structure of Protoaculeine B: Discovery of Neuronally Active Heterotricyclic Amino Acids2022
- Author(s)
  Otsuka Kazunori、Miyahara Masayoshi、Takaki Sara、Wakabayashi Ryoya、Miyako Kei、Irie Raku、Takamizawa Satoshi、Sakai Ryuichi、Oikawa Masato
- Journal Title
  
  European Journal of Organic Chemistry
  
  Volume: 2022 Issue: 36
- DOI
  10.1002/ejoc.202200669
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K23478
[Journal Article] Structural basis of the 24B3 antibody against the toxic conformer of amyloid β with a turn at positions 22 and 232022
- Author(s)
  Irie Yumi、Matsushima Yuka、Kita Akiko、Miki Kunio、Segawa Tatsuya、Maeda Masahiro、Yanagita Ryo C.、Irie Kazuhiro
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 621 Pages: 162-167
- DOI
  10.1016/j.bbrc.2022.07.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H00921
[Journal Article] Lysine-targeting inhibition of amyloid β oligomerization by a green perilla-derived metastable chalcone in vitro and in vivo.2022
- Author(s)
  Murakami, K., Sakaguchi, Y., Taniwa, K., Izuo, N., Hanaki, M., Kawase, T., Hirose, K., Nagao, C., Mizoguchi, K., Shimizu, T., Irie, K.
- Journal Title
  
  RSC Chem. Biol.
  
  Volume: 3 Issue: 12 Pages: 1380-1396
- DOI
  10.1039/d2cb00194b
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19607, KAKENHI-PROJECT-20H03583, KAKENHI-PROJECT-20K16006, KAKENHI-PROJECT-26221202
[Journal Article] Optimization of the Linker Length in the Dimer Model of E22P-Aβ40 Tethered at Position 382022
- Author(s)
  Chikugo Ayaka、Irie Yumi、Tsukano Chihiro、Uchino Ayumi、Maki Takahito、Kume Toshiaki、Kawase Taiji、Hirose Kenji、Kageyama Yusuke、Tooyama Ikuo、Irie Kazuhiro
- Journal Title
  
  ACS Chemical Neuroscience
  
  Volume: 13 Issue: 19 Pages: 2913-2923
- DOI
  10.1021/acschemneuro.2c00436
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H00921
[Journal Article] Design, synthesis, and biological activity of a synthetically accessible analog of aplysiatoxin with an (R)-(－)-carvone-based conformation-controlling unit2022
- Author(s)
  Suzuki Yoshiyuki、Moritoki Keiichi、Kajiwara Mizuki、Yanagita Ryo C.、Kawanami Yasuhiro、Hanaki Yusuke、Irie Kazuhiro
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 86 Pages: 1013-1023
- DOI
  10.1093/bbb/zbac084
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-17H06405, KAKENHI-PROJECT-22H04922
[Journal Article] Analysis of binding mode of vibsanin A with protein kinase C C1 domains: An experimental and molecular dynamics simulation study2022
- Author(s)
  Ryo C. Yanagita, Mao Otani, Satoshi Hatanaka, Hiroto Nishi, Shota Miyake, Yusuke Hanaki, Masashi Sato, Yasuhiro Kawanami, Kazuhiro Irie
- Journal Title
  
  Journal of Molecular Structure
  
  Volume: 1260 Pages: 132866-132866
- DOI
  10.1016/j.molstruc.2022.132866
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05846, KAKENHI-PLANNED-17H06405, KAKENHI-PROJECT-20K05852
[Journal Article] Structural analysis of the TxCo-1 antibody effective against the toxic conformer of amyloid β2022
- Author(s)
  Irie Kazuhiro、Irie Yumi、Matushima Yuka、Kita Akiko、Kageyama Yusuke、Tooyama Ikuo
- Journal Title
  
  Photon Factory Highlights 2021
  
  Volume: 2021 Pages: 30-31
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H00921
[Journal Article] APP Knock-In Mice Produce E22P-Aβ Exhibiting an Alzheimer’s Disease-like Phenotype with Dysregulation of Hypoxia-Inducible Factor Expression2022
- Author(s)
  Maki Takahito、Sawahata Masahito、Akutsu Ichiro、Amaike Shohei、Hiramatsu Genki、Uta Daisuke、Izuo Naotaka、Shimizu Takahiko、Irie Kazuhiro、Kume Toshiaki
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 21 Pages: 13259-13259
- DOI
  10.3390/ijms232113259
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09323, KAKENHI-PROJECT-22K09020, KAKENHI-PROJECT-22K19607, KAKENHI-PROJECT-20H03583, KAKENHI-PROJECT-19K07119, KAKENHI-PROJECT-20K16006, KAKENHI-PROJECT-26221202
[Journal Article] Toxic Amyloid-β42 Conformer May Accelerate the Onset of Alzheimer's Disease in the Preclinical Stage.2021
- Author(s)
  Futamura A, Hieda S, Mori Y, Kasuga K, Sugimoto A, Kasai H, Kuroda T, Yano S, Tsuji M, Ikeuchi T, Irie K, Ono K.
- Journal Title
  
  J Alzheimers Dis
  
  Volume: 80 Issue: 2 Pages: 639-646
- DOI
  10.3233/jad-201407
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K11266, KAKENHI-PROJECT-19H00921, KAKENHI-PROJECT-19K07965, KAKENHI-PROJECT-20K19111
[Journal Article] Development of a Novel Alzheimer's Disease Model Based on the Theory of the Toxic-conformer of Amyloid β2021
- Author(s)
  泉尾直孝、清水孝彦、村上一馬、入江一浩
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 141 Issue: 6 Pages: 843-849
- DOI
  10.1248/yakushi.20-00251-5
- NAID
  130008046322
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2021-06-01
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26221202, KAKENHI-PROJECT-20H03583, KAKENHI-PROJECT-20K16006
[Journal Article] アミロイドタンパク質を認識する核酸アプタマー2021
- Author(s)
  村上一馬、入江一浩
- Journal Title
  
  化学と生物
  
  Volume: 59 Pages: 216-218
- Data Source
  KAKENHI-PROJECT-26221202
[Journal Article] Synthesis of Alkyl Bridged‐Tris‐α‐Amino Acids as C3‐Symmetric and Linear Linkers2021
- Author(s)
  Uchino Ayumi、Tsukano Chihiro、Imamoto Tsuneo、Irie Kazuhiro
- Journal Title
  
  European Journal of Organic Chemistry
  
  Volume: 2021 Issue: 9 Pages: 1370-1377
- DOI
  10.1002/ejoc.202001592
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H00921
[Journal Article] Characterization of a Conformation-Restricted Amyloid β Peptide and Immunoreactivity of Its Antibody in Human AD brain2021
- Author(s)
  Kageyama Yusuke、Irie Yumi、Matsushima Yuka、Segawa Tatsuya、Bellier Jean-Pierre、Hidaka Kumi、Sugiyama Hiroshi、Kaneda Daita、Hashizume Yoshio、Akatsu Hiroyasu、Miki Kunio、Kita Akiko、Walker Douglas G.、Irie Kazuhiro、Tooyama Ikuo
- Journal Title
  
  ACS Chemical Neuroscience
  
  Volume: 12 Issue: 18 Pages: 3418-3432
- DOI
  10.1021/acschemneuro.1c00416
- NAID
  120007161279
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08853, KAKENHI-PROJECT-19H00921, KAKENHI-PROJECT-16H06277
[Journal Article] The Novel PKC Activator 10-Methyl-Aplog-1 Combined with JQ1 Induced Strong and Synergistic HIV Reactivation with Tolerable Global T Cell Activation2021
- Author(s)
  Washizaki Ayaka、Murata Megumi、Seki Yohei、Kikumori Masayuki、Tang Yinpui、Tan Weikeat、Wardani Nadita P.、Irie Kazuhiro、Akari Hirofumi
- Journal Title
  
  Viruses
  
  Volume: 13 Issue: 10 Pages: 2037-2037
- DOI
  10.3390/v13102037
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06405
[Journal Article] Searching for natural products that delay nucleation phase and promote elongation phase of amyloid beta42 toward Alzheimer's disease therapeutics2021
- Author(s)
  Murakami Kazuma, Horii Shiori, Hanaki Mizuho, Irie Kazuhiro
- Journal Title
  
  ACS Chemical Neuroscience
  
  Volume: 12 Issue: 18 Pages: 3467-3476
- DOI
  10.1021/acschemneuro.1c00489
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26221202
[Journal Article] Effects of side chain length of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, on PKC binding, anti-proliferative, and pro-inflammatory activities2021
- Author(s)
  Gonda Atsuko、Takada Koji、Yanagita Ryo C、Dan Shingo、Irie Kazuhiro
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 85 Issue: 1 Pages: 168-180
- DOI
  10.1093/bbb/zbaa024
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-17H06405, KAKENHI-PROJECT-16H06276
[Journal Article] Synthesis and biological activities of simplified aplysiatoxin analogs focused on the CH/π interaction2020
- Author(s)
  Kobayashi Takumi、Yanagita Ryo C.、Irie Kazuhiro
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 30 Issue: 24 Pages: 127657-127657
- DOI
  10.1016/j.bmcl.2020.127657
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-17H06405, KAKENHI-PROJECT-16H06276
[Journal Article] Control of the toxic conformation of amyloid β42 by intramolecular disulfide bond formation2020
- Author(s)
  Matsushima Yuka、Yanagita Ryo C.、Irie Kazuhiro
- Journal Title
  
  Chemical Communications
  
  Volume: 56 Issue: 29 Pages: 4118-4121
- DOI
  10.1039/d0cc01053g
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H00921
[Journal Article] An RNA aptamer with potent affinity for a toxic dimer of amyloid β42 has potential utility for histochemical studies of Alzheimer's disease2020
- Author(s)
  Murakami Kazuma, Obata Yayoi, Sekikawa Asa, Ueda Haruka, Awano Tatsuya, Takabe Keiji, Takahiko Shimizu, Irie Kazuhiro
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 295 Issue: 15 Pages: 4870-4880
- DOI
  10.1074/jbc.ra119.010955
- Description
  in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26221202, KAKENHI-PROJECT-16H06194, KAKENHI-PROJECT-20H03583
[Journal Article] Synthetic and biochemical studies on the effect of persulfidation on disulfide dimer models of amyloid β42 at position 35 in Alzheimer's etiology2020
- Author(s)
  Murakami Kazuma, Kato Haruka, Hanaki Mizuho, Monobe Yoko, Akagi Ken-ichi, Kawase Taiji, Hirose Kenji, Irie Kazuhiro
- Journal Title
  
  RSC Advances
  
  Volume: 10 Issue: 33 Pages: 19506-19512
- DOI
  10.1039/d0ra03429k
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26221202, KAKENHI-PROJECT-16H06194
[Journal Article] Evaluation of Toxic Amyloid β42 Oligomers in Rat Primary Cerebral Cortex Cells and Human iPS-derived Neurons Treated with 10-Me-Aplog-1, a New PKC Activator2020
- Author(s)
  Murakami Kazuma、Yoshimura Mayuko、Nakagawa Shota、Kume Toshiaki、Kondo Takayuki、Inoue Haruhisa、Irie Kazuhiro
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 4 Pages: 1179-1179
- DOI
  10.3390/ijms21041179
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07119, KAKENHI-PLANNED-17H06405, KAKENHI-PROJECT-17K16121
[Journal Article] Detection of amyloid β oligomers with RNA aptamers in AppNL-G-F/NL-G-F Mice: a model of Arctic Alzheimer’s disease2020
- Author(s)
  Obata Yayoi、*Murakami Kazuma、Kawase Taiji、Hirose Kenji、Izuo Naotaka、Shimizu Takahiko、*Irie Kazuhiro
- Journal Title
  
  ACS Omega
  
  Volume: 5 Issue: 34 Pages: 21531-21537
- DOI
  10.1021/acsomega.0c02134
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06194, KAKENHI-PROJECT-20H03583, KAKENHI-PROJECT-26221202
[Journal Article] Three structural features of functional food components and herbal medicine with amyloid β42 anti-aggregation properties2019
- Author(s)
  Murakami Kazuma, Irie Kazuhiro
- Journal Title
  
  Molecules
  
  Volume: 24 Issue: 11 Pages: 2125-2125
- DOI
  10.3390/molecules24112125
- NAID
  120006644072
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26221202, KAKENHI-PROJECT-16H06194
[Journal Article] Crystal structure analysis of the antibody that is specific to the toxic conformer of amyloid beta2019
- Author(s)
  Irie Kazuhiro、Irie Yumi、Kita Akiko
- Journal Title
  
  Photon Factory Activity Report 2018
  
  Volume: 36
- Data Source
  KAKENHI-PROJECT-19H00921
[Journal Article] New diagnostic method for Alzheimer's disease based on the toxic conformation theory of amyloid β2019
- Author(s)
  Irie Kazuhiro
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 84 Issue: 1 Pages: 1-16
- DOI
  10.1080/09168451.2019.1667222
- NAID
  120006800709
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-17H06405, KAKENHI-PROJECT-19H00921, KAKENHI-PROJECT-26221202
[Journal Article] Synthesis and Structure-Function Analyses of the Toxic Dimer and Trimer Models of Amyloid β2019
- Author(s)
  Irie Kazuhiro
- Journal Title
  
  Journal of Synthetic Organic Chemistry, Japan
  
  Volume: 77 Issue: 12 Pages: 1201-1208
- DOI
  10.5059/yukigoseikyokaishi.77.1201
- NAID
  130007760861
- ISSN
  0037-9980, 1883-6526
- Year and Date
  2019-12-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H00921, KAKENHI-PROJECT-26221202
[Journal Article] An App knock-in mouse inducing the formation of a toxic conformer of Aβ as a model for evaluating only oligomer-induced cognitive decline in Alzheimer's disease2019
- Author(s)
  Izuo Naotaka, Murakami Kazuma, Fujihara Yoshitaka, Maeda Masahiro, Saito Takashi, Saido C. Takaomi, Irie Kazuhiro, Shimizu Takahiko
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 515 Issue: 3 Pages: 462-467
- DOI
  10.1016/j.bbrc.2019.05.131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26221202
[Journal Article] Synthesis, Conformation, and Biological Activities of a Des-A-Ring Analog of 18-Deoxy-Aplog-1, a Simplified Analog of Debromoaplysiatoxin2019
- Author(s)
  Yanagita Ryo C.、Ashida Yoshiki、Kawanami Yasuhiro、Okamura Mutsumi、Dan Shingo、Irie Kazuhiro
- Journal Title
  
  HETEROCYCLES
  
  Volume: 99 Issue: 2 Pages: 942-942
- DOI
  10.3987/com-18-s(f)60
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-17H06405, KAKENHI-PROJECT-16H06276
[Journal Article] Synthesis and biochemical characterization of quasi-stable trimer models of full-length amyloid β40 with a toxic conformation2019
- Author(s)
  Irie Yumi、Hanaki Mizuho、Murakami Kazuma、Imamoto Tsuneo、Furuta Takumi、Kawabata Takeo、Kawase Taiji、Hirose Kenji、Monobe Yoko、Akagi Ken-ichi、Yanagita Ryo C.、Irie Kazuhiro
- Journal Title
  
  Chemical Communications
  
  Volume: 55 Issue: 2 Pages: 182-185
- DOI
  10.1039/c8cc08618d
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26221202, KAKENHI-PROJECT-18H02554
[Journal Article] Synthesis and biological activities of acetal analogs at position 3 of 10-methyl-aplog-1, a potential anti-cancer lead derived from debromoaplysiatoxin2018
- Author(s)
  Koutaro Hayakawa, Yusuke Hanaki, Harukuni Tokuda, Ryo C. Yanagita, Yu Nakagawa, Mutsumi Okamura, Shingo Dan, Kazuhiro Irie
- Journal Title
  
  Heterocycles
  
  Volume: 97 Issue: 1 Pages: 478-492
- DOI
  10.3987/com-18-s(t)37
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-17H06405, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16H05105
[Journal Article] アミロイドβ「毒性コンホマー」を標的にしたアルツハイマー病の治療・診断法の開発2018
- Author(s)
  泉尾直孝、清水孝彦、村上一馬、入江一浩
- Journal Title
  
  医薬品医療機器レギュラトリーサイエンス
  
  Volume: 49 Pages: 312-318
- Data Source
  KAKENHI-PROJECT-26221202
[Journal Article] Amyloid β toxic conformer has dynamic localization in the human inferior parietal cortex in absence of amyloid plaques2018
- Author(s)
  Kageyama Yusuke、Saito Atsushi、Pletnikova Olga、Rudow Gay L.、Irie Yumi、An Yang、Murakami Kazuma、Irie Kazuhiro、Resnick Susan M.、Fowler David R.、Martin Lee J.、Troncoso Juan C.
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 16895-16895
- DOI
  10.1038/s41598-018-35004-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221202
[Journal Article] Identification of protein kinase C isozymes involved in the anti-proliferative and pro-apoptotic activities of 10-Methyl-aplog-1, a simplified analog of debromoaplysiatoxin, in several cancer cell lines2018
- Author(s)
  Yusuke Hanaki, Yuki Shikata, Masayuki Kikumori, Natsuki Hotta, Masaya Imoto, Kazuhiro Irie
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 495 Issue: 1 Pages: 438-445
- DOI
  10.1016/j.bbrc.2017.11.052
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-17H06405, KAKENHI-PROJECT-15H03116, KAKENHI-PROJECT-16J04817, KAKENHI-PROJECT-18H02099
[Journal Article] Role of the carboxy groups of triterpenoids in their inhibition of the nucleation of amyloid β42 required for forming toxic oligomers2018
- Author(s)
  Murakami Kazuma、Yoshioka Takuya、Horii Shiori、Hanaki Mizuho、Midorikawa Satohiro、Taniwaki Shinji、Gunji Hiroki、Akagi Ken-ichi、Kawase Taiji、Hirose Kenji、Irie Kazuhiro
- Journal Title
  
  Chemical Communications
  
  Volume: 54 Issue: 49 Pages: 6272-6275
- DOI
  10.1039/c8cc03230k
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26221202, KAKENHI-PROJECT-16H06194
[Journal Article] Change of Amyloid-β 1-42 Toxic Conformer Ratio After Cerebrospinal Fluid Diversion Predicts Long-Term Cognitive Outcome in Patients with Idiopathic Normal Pressure Hydrocephalus2018
- Author(s)
  Akiba C, Nakajima M, Miyajima M, Ogino I, Motoi Y, Kawamura K, Adachi S, Kondo A, Sugano H, Tokuda T, Irie K, Arai H
- Journal Title
  
  J Alzheimers Dis.
  
  Volume: 25 Issue: 3 Pages: 989-1002
- DOI
  10.3233/jad-180059
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10372, KAKENHI-PROJECT-17K10908, KAKENHI-PROJECT-26221202, KAKENHI-PROJECT-18H02916
[Journal Article] Mechanistic analyses of the suppression of amyloid β42 aggregation by apomorphine2018
- Author(s)
  Mizuho Hanaki, Kazuma Murakami, Sumie Katayama, Ken-ichi Akagi, Kazuhiro Irie
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 26 Issue: 8 Pages: 1538-1546
- DOI
  10.1016/j.bmc.2018.01.028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26221202
[Journal Article] A toxic conformer of Aβ42 with a turn at 22-23 is a novel therapeutic target for Alzheimer’s disease2017
- Author(s)
  Naotaka Izuo, Chihiro Kasahara, Kazuma Murakami, Toshiaki Kume, Masahiro Maeda, Kazuhiro Irie, Koutaro Yokote, Takahiko Shimizu
- Journal Title
  
  Sci. Rep.
  
  Volume: 7 Issue: 1 Pages: 11811-11811
- DOI
  10.1038/s41598-017-11671-6
- NAID
  120006368174
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26221202, KAKENHI-PROJECT-17H01558, KAKENHI-PROJECT-15K07965, KAKENHI-PROJECT-16J05570, KAKENHI-PROJECT-15K19279
[Journal Article] 食品・生薬成分によるアミロイドβ42の凝集抑制機構の系統的解析2017
- Author(s)
  村上一馬、入江一浩
- Journal Title
  
  日本認知症学会誌
  
  Volume: 31 Pages: 351-360
- Data Source
  KAKENHI-PROJECT-26221202
[Journal Article] Synthetic models of quasi-stable amyloid β40 oligomers with significant neurotoxicity2017
- Author(s)
  Yumi Irie, Kazuma Murakami, Mizuho Hanaki, Yusuke Hanaki, Takashi Suzuki, Yoko Monobe, Tomoyo Takai, Ken-ichi Akagi, Taiji Kawase, Kenji Hirose, Kazuhiro Irie
- Journal Title
  
  ACS Chem. Neurosci.
  
  Volume: 8 Issue: 4 Pages: 807-816
- DOI
  10.1021/acschemneuro.6b00390
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26221202
[Journal Article] Semisynthesis and structure-activity studies of Uncarinic acid C Isolated from Uncaria rhynchophylla as a specific inhibitor of the nucleation phase in amyloid β42 aggregation2016
- Author(s)
  Takuya Yoshioka, Kazuma Murakami, Kyohei Ido, Mizuho Hanaki, Kanoko Yamaguchi, Satohiro Midorikawa, Shinji Taniwaki, Hiroki Gunji, Kazuhiro Irie
- Journal Title
  
  J. Nat. Prod.
  
  Volume: 79 Issue: 10 Pages: 2521-2529
- DOI
  10.1021/acs.jnatprod.6b00392
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26221202
[Journal Article] Structural optimization of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, as an anticancer lead2016
- Author(s)
  M. Kikumori, R. C. Yanagita, H. Tokuda, K. Suenaga, H. Nagai, and *K. Irie
- Journal Title
  
  Biosci. Biotechnol. Biochem.
  
  Volume: 80 Issue: 2 Pages: 888-895
- DOI
  10.1080/09168451.2015.1091718
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-23102011, KAKENHI-PROJECT-16K01911
[Journal Article] Monoclonal antibody with conformational specificity for a toxic conformer of amyloid β42 and its application toward the Alzheimer's disease diagnosis2016
- Author(s)
  Kazuma Murakami, Maki Tokuda, Takashi Suzuki, Yumi Irie, Mizuho Hanaki, Naotaka Izuo, Yoko Monobe, Ken-ichi Akagi, Ryotaro Ishii, Harutsugu Tatebe, Takahiko Tokuda, Masahiro Maeda, Toshiaki Kume, Takahiko Shimizu, Kazuhiro Irie
- Journal Title
  
  Sci. Rep.
  
  Volume: 6 Issue: 1 Pages: 29038-29038
- DOI
  10.1038/srep29038
- NAID
  120005774689
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221202, KAKENHI-PROJECT-26293165, KAKENHI-PROJECT-26462283, KAKENHI-PROJECT-16K14254, KAKENHI-PROJECT-15K07965, KAKENHI-PROJECT-15K09322, KAKENHI-PROJECT-15K19279, KAKENHI-PROJECT-16J05570
[Journal Article] Binding mode prediction of aplysiatoxin, a potent agonist of protein kinase C, through moleculer simulation and structure-activity study on simplified analogs of the receptor-recognition domain2016
- Author(s)
  Y Ashida, R. C. Yanagita*, C Takahashi, Y Kawanami, K Irie
- Journal Title
  
  Bioorg. Med. Chem
  
  Volume: 24 Issue: 18 Pages: 4218-4227
- DOI
  10.1016/j.bmc.2016.07.011
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23102011
[Journal Article] Structural insights into mechanisms for inhibiting amyloid β42 aggregation by non-catechol-type flavonoids2016
- Author(s)
  Mizuho Hanaki, Kazuma Murakami, Ken-ichi Akagi, Kazuhiro Irie*
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 24 Issue: 2 Pages: 304-313
- DOI
  10.1016/j.bmc.2015.12.021
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26221202
[Journal Article] アルツハイマー病の正確な早期診断の実現に向けて2016
- Author(s)
  入江一浩
- Journal Title
  
  化学
  
  Volume: 71 (11) Pages: 41-44
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26221202
[Journal Article] Synthesis and characterization of the amyloid β40 dimer model with a linker at position 30 adjacent to the intermolecular β-sheet region2015
- Author(s)
  Kazuma Murakami, Takashi Suzuki, Mizuho Hanaki, Yoko Monobe, Ken-ichi Akagi, Kazuhiro Irie*
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 466 Issue: 3 Pages: 463-467
- DOI
  10.1016/j.bbrc.2015.09.051
- NAID
  120005679859
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26221202
[Journal Article] アルツハイマー病様神経毒性におけるアミロイドβコンホマーの役割2015
- Author(s)
  泉尾直孝*、村上一馬、久米利明、前田雅弘、入江一浩、清水孝彦
- Journal Title
  
  基礎老化研究
  
  Volume: 39 Pages: 29-34
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26221202
[Journal Article] Synthesis and biological activities of the amide derivative of aplog-1, a simplified analog of aplysiatoxin with anti-proliferative and cytotoxic activity2015
- Author(s)
  Yusuke Hanaki, Ryo C. Yanagita, Takahiro Sugahara, Misako Aida, Harukuni Tokuda, Nobutaka Suzuki, Kazuhiro Irie
- Journal Title
  
  Biosci. Biotechnol. Biochem.
  
  Volume: 印刷中 Issue: 6 Pages: 888-895
- DOI
  10.1080/09168451.2014.1002452
- NAID
  120005676639
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23102011, KAKENHI-PUBLICLY-26102733
[Journal Article] Improved and Large-Scale Synthesis of 10-Methyl-Aplog-1, a Potential Lead for an Anticancer Drug.2014
- Author(s)
  Masayuki Kikumori, Ryo C. Yanagita, and Kazuhiro Irie
- Journal Title
  
  Tetrahedron
  
  Volume: 70 Issue: 52 Pages: 9776-9782
- DOI
  10.1016/j.tet.2014.11.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J02518, KAKENHI-PLANNED-23102011
[Journal Article] Synthesis and biological activities of simplified analogs of the natural PKC ligands, bryostatin-1 and aplysiatoxin2014
- Author(s)
  Kazuhiro Irie, Ryo C. Yanagita
- Journal Title
  
  Chem. Rec.
  
  Volume: 14 Issue: 2 Pages: 251-267
- DOI
  10.1002/tcr.201300036
- NAID
  120005651918
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-23102011
[Journal Article] Structure–Activity Relationship for (+)-Taxifolin Isolated from Silymarin as an Inhibitor of Amyloid β Aggregation2013
- Author(s)
  Sato, M., Murakami, K., (他5名), Irie, K
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 77 Issue: 5 Pages: 1100-1103
- DOI
  10.1271/bbb.120925
- NAID
  10031177604
- ISSN
  0916-8451, 1347-6947
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248015
[Journal Article] Structure-activity studies at position 27 of aplog-1, a simplified analog of debromoaplysiatoxin with anti-proliferative activity.2013
- Author(s)
  Yusuke Hanaki, Masayuki Kikumori, Sayo Ueno, Harukuni Tokuda, Nobutaka Suzuki and Kazuhiro Irie
- Journal Title
  
  Tetrahedron
  
  Volume: 69 Issue: 36 Pages: 7936-7645
- DOI
  10.1016/j.tet.2013.02.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J02518, KAKENHI-PLANNED-23102011
[Journal Article] Intracellular accumulation of toxic turn amyloid-β is associated with endoplasmic reticulum stress in Alzheimer's disease2013
- Author(s)
  Soejima, N., Ohyagi, Y., (他6名), Murakami, K., Irie, K., (他5名)
- Journal Title
  
  Curr. Alzheimer Res
  
  Volume: 10 Pages: 11-20
- URL
  http://www.eurekaselect.com/106388/article
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248015
[Journal Article] Site-specific inhibitory mechanism for amyloid-β42 aggregation by catechol-type flavonoids targeting the Lys-residues2013
- Author(s)
  Sato, M., Murakami, K., Ikubo, H., Uno, M., Nakagawa, Y., Katayama, S., Akagi, K.-i., Masuda, Y., Takegoshi, K., *Irie, K
- Journal Title
  
  J.Biol.Chem
  
  Volume: 288 Issue: 32 Pages: 23212-23224
- DOI
  10.1074/jbc.m113.464222
- NAID
  120005477416
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248015, KAKENHI-PROJECT-24780108
[Journal Article] A drug screening platform for Alzheimer's disease with intracellular Aβ oligomers using patient-specific iPSCs2013
- Author(s)
  Kondo, T., (他24名), Murakami, K., Irie, K., Klein, W. L., Mori, H., Asada, T., Takahashi, R., Iwata, N., Yamanaka, S., Inoue, H
- Journal Title
  
  Cell Stem Cell
  
  Volume: 12 Issue: 4 Pages: 487-496
- DOI
  10.1016/j.stem.2013.01.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21248015, KAKENHI-PLANNED-22129006, KAKENHI-ORGANIZER-23111001, KAKENHI-PLANNED-23111002, KAKENHI-PROJECT-23249049, KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-23592093, KAKENHI-PROJECT-24220009, KAKENHI-PROJECT-24500408, KAKENHI-PROJECT-24590040, KAKENHI-PROJECT-24700367, KAKENHI-PROJECT-24790260, KAKENHI-PROJECT-24790276, KAKENHI-PUBLICLY-25123709, KAKENHI-PROJECT-25290018, KAKENHI-PROJECT-25460341, KAKENHI-PUBLICLY-23110535, KAKENHI-PUBLICLY-23123510
[Journal Article] Inhibition of Amyloid β Aggregation by Acteoside, a Phenylethanoid Glycoside2013
- Author(s)
  M. Kurisu, Y. Miyamae, K. Murakami, J. Han, H. Isoda, K. Irie, and H. Shigemori
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 77 Issue: 6 Pages: 1329-1332
- DOI
  10.1271/bbb.130101
- NAID
  10031184707
- ISSN
  0916-8451, 1347-6947
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24580156
[Journal Article] Structure-activity studies on the side chain of a simplified analog of aplysiatoxin (aplog-1) with anti-proliferative activit2013
- Author(s)
  Kamachi, H., Tanaka, K., Yanagita, R. C., Murakami, A., Murakami, K., Tokuda, H., Suzuki, N., Nakagawa, Y., Irie, K.
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 21 Issue: 10 Pages: 2695-2702
- DOI
  10.1016/j.bmc.2013.03.013
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23102011
[Journal Article] Non-toxic conformer of Aβ42 may suppress Aβ42-induced toxicity in rat primary neurons : implications for the novel therapeutic strategy of Alzheimer's disease2013
- Author(s)
  Izuo, N., Murakami, K., (他3名), Shimizu, T., Akaike, A., Irie, K., Kume, T
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 438 Issue: 1 Pages: 1-5
- DOI
  10.1016/j.bbrc.2013.05.106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248015, KAKENHI-PROJECT-24390139, KAKENHI-PROJECT-24590111, KAKENHI-PROJECT-25460095, KAKENHI-PROJECT-25670036
[Journal Article] Effects of the methoxy group in the side chain of dehromoaplysiatoxin on its tumor-promoting and anti-proliferative activities2013
- Author(s)
  Ryo C. Yanagita, Hiroaki Kamachi, Masayuki Kikumori, Harukuni Tokuda, Nobutaka Suzuki, Kiyotake Suenaga, Hiroshi Nagai and Kazuhiro Irie
- Journal Title
  
  Bioorganic and Medicinal Chemistry Letters
  
  Volume: 23 Issue: 15 Pages: 4319-4323
- DOI
  10.1016/j.bmcl.2013.05.096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J02518, KAKENHI-PLANNED-23102011
[Journal Article] Development of new anticancer drugs based on the activation mechanism of protein kinase Cδ2012
- Author(s)
  Kazuhiro Irie, 他2名
- Journal Title
  
  Med.Res.Rev.
  
  Volume: (印刷中) Issue: 3 Pages: 518-535
- DOI
  10.1002/med.20220
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23102011
[Journal Article] Structure#8211;activity studies on the spiroketal moiety of a simplified analog of debromoaplysiatoxin with antiproliferative activity2012
- Author(s)
  M. Kikumori, R. C. Yanagita, H. Tokuda, N. Suzuki, H. Nagai, K. Suenaga, K. Irie
- Journal Title
  
  J. Med. Chem.
  
  Volume: 55 Pages: 5614-5626
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-23102001
[Journal Article] Protective effects of caffeoylquinic acids on the aggregation and neurotoxicity of the 42-residue amyloid β-protein2012
- Author(s)
  Y. Miyamae, M. Kurisu, K. Murakami, J. Han, H. Isoda, K. Irie, and H. Shigemori
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 20 Pages: 5844-5849
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24580156
[Journal Article] Toxicity in rat primary neuron through the cellular oxidative stress induced by the turn formation 22 and 23 of AB422012
- Author(s)
  Naotaka Izuo
- Journal Title
  
  ACS Chemycal Neuroscience
  
  Volume: 3(9) Issue: 9 Pages: 647-681
- DOI
  10.1021/cn300033k
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J04068, KAKENHI-PROJECT-21248015, KAKENHI-PROJECT-23790083, KAKENHI-PROJECT-24390139, KAKENHI-PROJECT-24590111
[Journal Article] Early accumulation of intracellular fibrillar oligomers and late congophilic amyloid angiopathy in mice expressing the Osaka intra-Aβ APP mutation2012
- Author(s)
  Kulic, L., (他10名), Shimizu, T., Murakami, K., Irie, K., (他4名)
- Journal Title
  
  Transl. Psychiatry
  
  Volume: 2 Issue: 11 Pages: e183-e183
- DOI
  10.1038/tp.2012.109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248015
[Journal Article] Synthesis and structure-activity studies of simplified analogs of aplysiatoxin with antiproliferative activity like brvostatin-12012
- Author(s)
  Kazuhiro Irie, 他9名
- Journal Title
  
  Pure Appl.Chem.
  
  Volume: (印刷中) Issue: 6 Pages: 1341-1351
- DOI
  10.1351/pac-con-11-08-22
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23102011, KAKENHI-PROJECT-24510294
[Journal Article] Identification and Biological Activities of Bryostatins from Japanese Bryozoan2012
- Author(s)
  Sayo Ueno
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 76 Issue: 5 Pages: 1041-1043
- DOI
  10.1271/bbb.120026
- NAID
  10030753324
- ISSN
  0916-8451, 1347-6947
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23658100
[Journal Article] Stimulation of the Amyloidogenic Pathway by Cytoplasmic Superoxide Radicals in an Alzheimer's Disease Mouse Model2012
- Author(s)
  Murakami, K., Murata, N., Noda, Y., Irie, K., Shirasawa, T., Shimizu, T
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 76 Issue: 6 Pages: 1098-1103
- DOI
  10.1271/bbb.110934
- NAID
  10030817824
- ISSN
  0916-8451, 1347-6947
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248015, KAKENHI-PROJECT-22603006
[Journal Article] SOD1 (cupper/zinc superoxide dismutase) deficiency drives amyloid β protein oligomerization and memory loss in mouse model of Alzheimer's disease2011
- Author(s)
  Murakami, K., (他8名), Irie, K., Shirasawa, T., Shimizu, T
- Journal Title
  
  J. Biol. Chem
  
  Volume: 286 Issue: 52 Pages: 44557-44568
- DOI
  10.1074/jbc.m111.279208
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248015, KAKENHI-PROJECT-22300118, KAKENHI-PROJECT-22603006
[Journal Article] Solid-state NMR analysis of interaction sites of curcumin and 42-residue amyloid β-protein fibrils2011
- Author(s)
  Masuda, Y., Fukuchi, M., Yatagawa, T., Tada, M., Takeda, K., Irie, K., Akagi, K., Monobe, Y., Imazawa, T., Takegoshi, K.
- Journal Title
  
  Bioorganic and Medicinal Chemistry
  
  Volume: 19 Issue: 20 Pages: 5967-5974
- DOI
  10.1016/j.bmc.2011.08.052
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-09J01128, KAKENHI-PROJECT-21248015, KAKENHI-PLANNED-23102011
[Journal Article] Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 232010
- Author(s)
  Murakami, K., (他8名), Shimizu, T., Irie, K
- Journal Title
  
  ACS Chem. Neurosci
  
  Volume: 1 Issue: 11 Pages: 747-756
- DOI
  10.1021/cn100072e
- NAID
  130004504903
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248015
[Journal Article] E22Δ mutation in amyloid β-protein promotes β-sheet transformation, radical production, and synaptotoxicity, but not neurotoxicity2010
- Author(s)
  Suzuki, T., Murakami, K., (他7名), Irie, K
- Journal Title
  
  Int. J. Alzheimers Dis
  
  Volume: 431320 Issue: 1
- DOI
  10.4061/2011/431320
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248015
[Journal Article] Silymarin Attenuated the Amyloid .BETA. Plaque Burden and Improved Behavioral Abnormalities in an Alzheimer's Disease Mouse Model2010
- Author(s)
  Murata, N., Murakami, K., Ozawa, Y., Kinoshita, N., Irie, K., Shirasawa, T., Shimizu T
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 74 Issue: 11 Pages: 2299-2306
- DOI
  10.1271/bbb.100524
- NAID
  10027561730
- ISSN
  0916-8451, 1347-6947
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248015
[Journal Article] The turn formation at positions 22 and 23 in the 42-mer amyloid beta peptide : the emerging role in the pathogenesis of Alzheimer's disease2010
- Author(s)
  Murakami, K., Masuda, Y., Shirasawa, T., Shimizu, T., Irie, K
- Journal Title
  
  Geriatr. Gerontol. Int
  
  Volume: 10 Issue: s1
- DOI
  10.1111/j.1447-0594.2010.00598.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248015
[Journal Article] Identification of Physiological and Toxic Conformations in Aβ42 Aggregates2009
- Author(s)
  Y. Masuda,(他3名) K. Takegoshi, T. Shimizu, T. Shirasawa, K. Irie
- Journal Title
  
  ChemBioChem 10
  
  Pages: 287-295
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208011
[Journal Article] Identification of physiological and toxic conformations in Aβ42 aggregates2009
- Author(s)
  Y. Masuda, 他3名, 2-4番目, K. Takegoshi, T. Shimizu, T. Shirasawa, *K. Irie
- Journal Title
  
  ChemBioChem 10
  
  Pages: 287-295
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208011
[Journal Article] Isomerization and/or racemization at Asp23 of Aβ42 do not increase its aggregative ability, neurotoxicity, and radical productivity in vitro2008
- Author(s)
  K. Murakami, M. Uno, Y. Masuda, T. Shimizu, T. Shirasawa, *K. Irie,
- Journal Title
  
  Biochem. Biophys. Res. Commun. 366
  
  Pages: 745-751
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208011
[Journal Article] Verification of the C-terminal intramolecular β-sheet in Aβ42 aggregates using solid-state NMR2008
- Author(s)
  Y. Masuda, 他3名, 2-4番目, K. Takegoshi, T. Shimizu, T. Shirasawa, *K. Irie
- Journal Title
  
  Bioorg. Med. Chem. Lett. 18
  
  Pages: 3206-3210
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208011
[Journal Article] βアミロイドの毒性コンホメーシヨン2008
- Author(s)
  入江一浩
- Journal Title
  
  化学と生物 46
  
  Pages: 431-434
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208011
[Journal Article] βアミロイドの毒性コンポメ-ション2008
- Author(s)
  入江一浩, 増田裕一
- Journal Title
  
  化学と生物 46
  
  Pages: 431-434
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208011
[Journal Article] アミロイドβ (Aβ42) の毒性コンホメーションの提唱2008
- Author(s)
  *村上一馬, 清水孝彦, 白澤卓二, 入江一浩
- Journal Title
  
  基礎老化研究 32
  
  Pages: 25-29
- NAID
  10024377833
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208011
[Journal Article] Verification of the intermolecular parallel β-sheet in E22K-Aβ42 aggregates by solid-state NMR using rotational resonance : implications for the supramolecular arrangement of the toxic conformer of Aβ422008
- Author(s)
  Y. Masuda, 他2名, 2-3番目, K. Takegoshi, T. Shimizu, T. Shirasawa, *K. Irie
- Journal Title
  
  Biosci. Biotechnol. Biochem. 72
  
  Pages: 2170-2175
- NAID
  10027531218
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208011
[Journal Article] βアミロイドの毒性コンホメーション2008
- Author(s)
  *入江一浩, 増田裕一
- Journal Title
  
  化学と生物 46
  
  Pages: 431-434
- NAID
  10024333845
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208011
[Journal Article] Verification of the Intermolecular Parallel 13-sheet in E22K-Aβ42 Aggregates by Solid-state NMR Using Rotational Resonance : Implications for the Supramolecular Arrangement of the Toxic Conformer of Aβ42. Biosci.2008
- Author(s)
  Y. Masuda,(他3名),K. Takegoshi, T. Shimizu, T. Shirasawa, K. Irie
- Journal Title
  
  Biotechnol. Biochem 72
  
  Pages: 2170-2175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208011
[Journal Article] Distance measurement between Tyr-10 and Met-35 in amyloid β by site-directed spin labeling ESR : implications for the stronger neurotoxicity of Aβ42 than Aβ402007
- Author(s)
  K. Murakami, H. Hara, Y. Masuda, H. Ohigashi, *K. Irie
- Journal Title
  
  ChemBioChem 8
  
  Pages: 2308-2314
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208011
[Journal Article] The Toxic Conformation of the 42-residue Amyloid β Peptide and Its Relevance to Oxidative Stress in Alzheimer's Disease.2007
- Author(s)
  K. Irie., K. Murakami,(他5名) K. Takegoshi, H. Fukuda, M. Nagao, T. Shimizu, T. Shirasawa
- Journal Title
  
  Mini-Rev. Med. Chem 7
  
  Pages: 1001-1008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208011
[Journal Article] The toxic conformation of the 42-residue amyloid β peptide and its relevance to oxidative stress in Alzheimer's disease2007
- Author(s)
  *K. Irie., K. Murakami, 他5名, 3-7番目, K. Takeoshi, H. Fukuda, M. Nagao, T. Shimizu, T. Shirasawa
- Journal Title
  
  Mini-Rev. Med. Chem. 7
  
  Pages: 1001-1008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208011
[Journal Article] Distance Measurement between Tyr-10 and Met-35 in Amyloid (3 by Site-directed Spin Labeling ESR : Implications for the Stronger Neurotoxicity of Aβ342 than Aβ3402007
- Author(s)
  K. Murakami, H. Hara, Y. Masuda, H. Ohigashi, K. Irie
- Journal Title
  
  ChemBioChem 8
  
  Pages: 2308-2314
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208011
[Journal Article] The toxic conformation of the 42-residue amyloid β peptide and its relevance to oxidative stress in Alzheimer's disease2007
- Author(s)
  Kazuhiro Irie
- Journal Title
  
  Mini-Reviews in Medicinal Chemistry (in press)
- Data Source
  KAKENHI-PROJECT-18208011
[Journal Article] The toxic conformation of the 42-residue amyloid β peptide and its relevance to oxidative stress in Alzheimer's disease2007
- Author(s)
  Kazuhiro Irie
- Journal Title
  
  Mini-Reviews in Medicinal Chemistry 7
  
  Pages: 1001-1008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208011
[Journal Article] CH/π 相互作用を利用した薬剤開発2006
- Author(s)
  入江一浩
- Journal Title
  
  ファルマシア 42・5
  
  Pages: 427-430
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15208012
[Journal Article] Design and synthesis of 8-octyl-benzolactam-V9, the selective activator for PKCε and η.2006
- Author(s)
  Y.Nakagawa, K.Irie, R.C.Yanagita, H.Ohigashi, K.-i.Tsuda, K.Kashiwagi, N.Saito
- Journal Title
  
  J. Med. Chem. 49 (9)
  
  Pages: 2681-2688
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15208012
[Journal Article] Development of new medicinal leads based on the CH/π interaction.2006
- Author(s)
  K.Irie
- Journal Title
  
  Pharmacia 42 (5)
  
  Pages: 427-430
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15208012
[Journal Article] CH/π相互作用を利用した薬剤開発2006
- Author(s)
  入江一浩
- Journal Title
  
  ファルマシア 42・5
  
  Pages: 427-430
- Data Source
  KAKENHI-PROJECT-15208012
[Journal Article] CH/π相互作用を利用した薬剤開発2006
- Author(s)
  入江一浩
- Journal Title
  
  ファルマシア 42・5
  
  Pages: 427-430
- Data Source
  KAKENHI-PROJECT-18032041
[Journal Article] Verification of the turn at positions 22 and 23 of the β-amyloid fibrils using solid-state NMR : implication for the pathogenesis of Alzheimer's disease.2005
- Author(s)
  Y.Masuda, K.Irie, K.Murakami, H.Ohigashi, R.Ohashi, K.Takegoshi, T.Shimizu, T.Shirasawa
- Journal Title
  
  Bioorg.Med.Chem. 13(24)
  
  Pages: 6803-6809
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16380080
[Journal Article] Toward the development of new medicinal leads with selectivity for protein kinase C isozymes2005
- Author(s)
  Kazuhiro Irie
- Journal Title
  
  The Chemical Record 5・4
  
  Pages: 185-195
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15208012
[Journal Article] Structure of β-amyloid fibrils and its relevance to their neurotoxicity : implications for the pathogenesis of Alzheimer's disease.2005
- Author(s)
  K.Irie, K.Murakami, Y.Masuda, A.Morimoto, H.Ohigashi, R.Ohashi, K.Takegoshi, M.Nagao, T.Shimizu, T.Shirasawa
- Journal Title
  
  J.Biosci.Bioeng. 99(55)
  
  Pages: 437-447
- NAID
  110002695685
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16380080
[Journal Article] Toward the development of new medicinal leads with selectivity for protein kinase C isozymes2005
- Author(s)
  Kazuhiro Irie
- Journal Title
  
  The Chemical Record 5・4
  
  Pages: 185-195
- Data Source
  KAKENHI-PROJECT-17035046
[Journal Article] Indolactam-V is involved in the CH/π interaction with Pro-11 of the PKCδ C1B domain : application for the structural optimization of the PKCδ ligand.2005
- Author(s)
  Y.Nakagawa, K.Irie, R.C Yanagita, H.Ohigashi, K.-i.Tsuda
- Journal Title
  
  J. Am. Chem. Soc. 127 (16)
  
  Pages: 5746-5747
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15208012
[Journal Article] New aggregation model of amyloid β by the systematic proline replacement.2005
- Author(s)
  K.Murakami, K.Irie, A.Morimoto, Y.Masuda, H.Ohigashi, M.Nagao, H.Fukuda, T.Shimizu, T.Shirasawa
- Journal Title
  
  In Peptide Science 2004, Shimohigashi, Y.(Ed.), The Japanese Peptide Society, Fukuoka, Japan
  
  Pages: 179-182
- NAID
  10014459824
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16380080
[Journal Article] Formation and stabilization model of the 42-mer Aβ radical : implications for the long-lasting oxidative stress in Alzheimer's disease.2005
- Author(s)
  K.Murakami, K.Irie, H.Ohigashi, H.Hara, M.Nagao, T.Shimizu, T.Shirasawa
- Journal Title
  
  J.Am.Chem.Soc. 127(43)
  
  Pages: 15168-15174
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16380080
[Journal Article] Toward the development of new medicinal leads with selectivity for protein kinase C isozymes.2005
- Author(s)
  K.Irie, Y.Nakagawa, H.Ohigashi
- Journal Title
  
  Chem. Rec. 5 (4)
  
  Pages: 185-195
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15208012
[Journal Article] Structure of β-amyloid fibrils and its relevance to their neurotixicity : implications for the pathogenesis of Alzheimer's disease2005
- Author(s)
  Kazuhiro Irie
- Journal Title
  
  Journal of Bioscience and Bioengineering 99・5
  
  Pages: 437-447
- Data Source
  KAKENHI-PROJECT-17025051
[Journal Article] Structure of β-Amyloid Fibrils and Its Relevance to Their Neurotoxicity : Implications for the Pathogenesis of Alzheimer's Disease2005
- Author(s)
  Kazuhiro Irie
- Journal Title
  
  Journal of Bioscience and Bioengineering 99・5(in press)
- NAID
  110002695685
- Data Source
  KAKENHI-PROJECT-16380080
[Journal Article] Structure of β-amyloid fibrils and its relevance to their neurotoxicity : implications for the pathogenesis of Alzheimer's disease2005
- Author(s)
  Kazuhiro Irie
- Journal Title
  
  Journal of Bioscience and Bioengineering 99・5
  
  Pages: 437-447
- NAID
  110002695685
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16380080
[Journal Article] Indolactam and benzolactam compounds as new medicinal leads with binding selectivity for C1 domains of protein kinase C isozymes.2004
- Author(s)
  K.Irie, Y.Nakagawa, H.Ohigashi
- Journal Title
  
  Curr. Pharm. Design 10 (12)
  
  Pages: 1371-1385
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15208012
[Journal Article] Indolactam and Benzolactam Compounds as New Medicinal Leads with Binding Selectivity for C1 Domains of Protein Kinase C Isozymes2004
- Author(s)
  Kazuhiro Irie
- Journal Title
  
  Current Pharmaceutical Design 10・12
  
  Pages: 1371-1385
- Data Source
  KAKENHI-PROJECT-15208012
[Journal Article] Tumor promoter binding of the protein kinase C C1 homology domain peptides of RasGRPs, chimaerins, and Unc13s2004
- Author(s)
  Kazuhiro Irie
- Journal Title
  
  Bioorganic & Medicinal Chemistry 12・17
  
  Pages: 4575-4583
- Data Source
  KAKENHI-PROJECT-15208012
[Journal Article] Functional analysis of the phorbol ester receptors using a peptide synthesis.2004
- Author(s)
  K.Irie, H.Ohigashi
- Journal Title
  
  Kagaku to Seibutsu 42 (1)
  
  Pages: 54-62
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15208012
[Journal Article] ペプチド合成によるホルボールエステル受容体の機能解析2004
- Author(s)
  入江一浩
- Journal Title
  
  化学と生物 42・1
  
  Pages: 54-62
- NAID
  10012135570
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15208012
[Journal Article] Analysis of the secondary structure of β-amyloid (Aβ42) fibrils by systematic proline replacement.2004
- Author(s)
  A.Morimoto, K.Irie, K.Murakami, Y.Masuda, H.Ohigashi, M.Nagao, H.Fukuda, T.Shimizu, T.Shirasawa
- Journal Title
  
  J.Biol.Chem. 279(50)
  
  Pages: 52781-52788
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16380080
[Journal Article] Tumor promoter binding of the protein kinase C C1 homology domain peptides of RasGRPs, chimaerins, and Unc13s.2004
- Author(s)
  K.Irie, A.Masuda, M.Shindo, Y.Nakagawa, H.Ohigashi
- Journal Title
  
  Bioorg. Med. Chem. 12 (17)
  
  Pages: 4575-4583
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15208012
[Journal Article] Indolactam and benzolactam compounds as new medicinal leads with binding selectivity for C1 domains of protein kinase C isozymes2004
- Author(s)
  Kazuhiro Irie
- Journal Title
  
  Current Pharmaceutical Design 10・12
  
  Pages: 1371-1385
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15208012
[Journal Article] Synthesis, conformation and PKC isozyme surrogate binding of indolinelactam-Vs, new conformationally-restricted analogues of (-)-indolactam-V.2004
- Author(s)
  Y.Nakagawa, K.Irie, Y.Komiya, H.Ohigashi, K.-i.Tsuda
- Journal Title
  
  Tetrahedron 60 (33)
  
  Pages: 7077-7084
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15208012
[Journal Article] Tumor promoter binding of the protein kinse C C1 homology domain peptides of RasGRPs, chimaerins, and Unc13s2004
- Author(s)
  Kazuhiro Irie
- Journal Title
  
  Bioorganic ＆ Medicinal Chemistry 12・7
  
  Pages: 4575-4583
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15208012
[Journal Article] Synthesis and binding selectivity of 7-and 15-decylbenzolactone-V8 for the C1 domains of protein kinase C isozymes.2003
- Author(s)
  Y.Nakagawa, K.Irie, N.Yamanaka, H.Ohigashi, K.-i.Tsuda
- Journal Title
  
  Bioorg. Med. Chem. Lett. 13 (18)
  
  Pages: 3015-3019
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15208012
[Journal Article] Analysis of the non-covalent interaction beween metal ions and the cysteine-rich domain of protein kinase C eta by electrospray ionization mass spectrometry.2003
- Author(s)
  M.Shindo, K.Irie, H.Fukuda, H.Ohigashi
- Journal Title
  
  Bioorg. Med. Chem. 11 (23)
  
  Pages: 5075-5082
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15208012
[Journal Article] Synthesis and phorbol ester binding of the cysteine-rich domains of diacylglycerol kinase (DGK) isozymes; DGKγ and DGKβ are new targets of tumor-promoting phorbol esters.2003
- Author(s)
  M.Shindo, K.Irie, A.Masuda, H.Ohigashi, Y.Shirai, K.Miyasaka, N.Saito
- Journal Title
  
  J. Biol. Chem. 278 (20)
  
  Pages: 18448-18454
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15208012
[Patent] 配座固定アミロイドβ４２誘導体2024
- Inventor(s)
  入江一浩、入江由美、遠山育夫、景山裕介
- Industrial Property Rights Holder
  入江一浩、入江由美、遠山育夫、景山裕介
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2024-010920
- Filing Date
  2024
- Data Source
  KAKENHI-PROJECT-23H00325
[Patent] 抗アミロイドβ４２モノクローナル抗体2021
- Inventor(s)
  入江一浩、松島由佳、入江由美、遠山育夫、景山裕介
- Industrial Property Rights Holder
  入江一浩、松島由佳、入江由美、遠山育夫、景山裕介
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-059059
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-19H00921
[Patent] アミロイドβ42架橋アナログペプチド2020
- Inventor(s)
  入江一浩、松島由佳
- Industrial Property Rights Holder
  入江一浩、松島由佳
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-19H00921
[Patent] アミロイドβの22位及び23位のターン構造を極めて特異的に認識する抗体（学内整理番号：4718）2015
- Inventor(s)
  入江一浩，村上一馬，清水孝彦，泉尾直孝，清藤勉
- Industrial Property Rights Holder
  入江一浩，村上一馬，清水孝彦，泉尾直孝，清藤勉
- Industrial Property Rights Type
  特許
- Filing Date
  2015-12-14
- Overseas
- Data Source
  KAKENHI-PROJECT-26221202
[Patent] アミロイドβの22位及び23位のターン構造を極めて特異的に認識する抗体2014
- Inventor(s)
  入江一浩，村上一馬，清水孝彦，泉尾直孝，清藤　勉
- Industrial Property Rights Holder
  入江一浩，村上一馬，清水孝彦，泉尾直孝，清藤　勉
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-251898
- Filing Date
  2014-12-12
- Data Source
  KAKENHI-PROJECT-26221202
[Patent] 新規アプリシアトキシン誘導体及びそれを含有する抗がん剤2013
- Inventor(s)
  入江一浩, 菊森将之, 蒲池弘明, 柳田亮, 中川優
- Industrial Property Rights Holder
  国立大学法人京都大学
- Industrial Property Rights Type
  特許
- Filing Date
  2013-04-16
- Acquisition Date
  2017-07-07
- Data Source
  KAKENHI-PLANNED-23102011
[Patent] 新規アプリシアトキシン誘導体及びそれを含有する抗がん剤2013
- Inventor(s)
  入江一浩，菊森将之，蒲池弘明，柳田亮，中川優
- Industrial Property Rights Holder
  入江一浩，菊森将之，蒲池弘明，柳田亮，中川優
- Industrial Property Rights Type
  特許
- Filing Date
  2013-04-16
- Overseas
- Data Source
  KAKENHI-ORGANIZER-23102001
[Patent] 新規アプリシアトキシン誘導体及びそれを含有する抗がん剤2012
- Inventor(s)
  入江一浩，菊森将之，蒲池弘明，柳田　亮，中川　優
- Industrial Property Rights Holder
  入江一浩，菊森将之，蒲池弘明，柳田　亮，中川　優
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2012-092842
- Filing Date
  2012-04-16
- Data Source
  KAKENHI-ORGANIZER-23102001
[Patent] 新規アプリシアトキシン誘導体及びそれを含有する抗がん剤2012
- Inventor(s)
  入江一浩，菊森将之，蒲池弘明，柳田　亮，中川　優
- Industrial Property Rights Holder
  入江一浩，菊森将之，蒲池弘明，柳田　亮，中川　優
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2012-092842
- Filing Date
  2012-04-16
- Data Source
  KAKENHI-PLANNED-23102011
[Patent] アミロイド β のターン構造を認識する抗体2011
- Inventor(s)
  入江一浩, 村上一馬, 増田裕一, 清水孝彦,白澤卓二, 清藤勉
- Industrial Property Rights Holder
  入江一浩, 村上一馬, 増田裕一, 清水孝彦,白澤卓二, 清藤勉
- Industrial Property Rights Type
  特許
- Filing Date
  2011-04-21
- Overseas
- Data Source
  KAKENHI-PROJECT-21248015
[Patent] Antibody recognizing tumstructure in amyloid β2010
- Inventor(s)
  Kazuhiro Irie, Kazuma Murakami, Yuichi Masuda, Takahiko Shimizu, Takuji Shirasawa, Tsutomu Seito
- Industrial Property Rights Holder
  Kazuhiro Irie, Kazuma Murakami, Yuichi Masuda, Takahiko Shimizu, Takuji Shirasawa, Tsutomu Seito
- Industrial Property Rights Type
  特許
- Filing Date
  2010-10-18
- Acquisition Date
  2014-04-29
- Overseas
- Data Source
  KAKENHI-PROJECT-21248015
[Patent] アミロイドβのターン構造を認識する抗体2009
- Inventor(s)
  入江一浩, 他5名
- Industrial Property Rights Holder
  入江一浩, 他5名
- Industrial Property Number
  2009-239542
- Filing Date
  2009-10-16
- Data Source
  KAKENHI-PROJECT-21248015
[Patent] βアミロイド、及びそれを用いたアルツハイマー病治療薬又は予防薬のスクリーニング方法2005
- Inventor(s)
  入江一浩他5名
- Industrial Property Rights Holder
  入江一浩他5名
- Industrial Property Number
  2005-087184
- Filing Date
  2005-03-24
- Data Source
  KAKENHI-PROJECT-17025051
[Patent] βアミロイド,及びそれを用いたアルツハイマ-病治療薬又は予防薬のスクリ-ニング方法2005
- Inventor(s)
  入江一浩, 村上一馬, 大東肇, 永尾雅哉, 白澤卓二, 清水孝彦
- Industrial Property Rights Holder
  入江一浩, 村上一馬, 大東肇, 永尾雅哉, 白澤卓二, 清水孝彦
- Patent Publication Number
  2006-265189
- Filing Date
  2005-03-24
- Data Source
  KAKENHI-PROJECT-18208011
[Patent] βアミロイド, 及びそれを用いたアルツハイマー病治療薬又は予防薬のスクリーニング方法2005
- Inventor(s)
  入江一浩, 村上一馬, 大東肇, 永尾雅哉, 白澤卓二, 清水孝彦
- Industrial Property Rights Holder
  入江一浩, 村上一馬, 大東肇, 永尾雅哉, 白澤卓二, 清水孝彦
- Patent Publication Number
  2006-265189
- Filing Date
  2005-03-24
- Data Source
  KAKENHI-PROJECT-18208011
[Patent] βアミロイド、及びそれを用いたアルツハイマー病治療薬又は予防薬のスクリーニング方法2005
- Inventor(s)
  入江一浩他5名
- Industrial Property Rights Holder
  入江一浩他5名
- Industrial Property Number
  2005-087184
- Filing Date
  2005-03-24
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16380080
[Patent] βアミロイド、及びそれを用いたアルツハイマー病治療薬又は予防薬のスクリーニング方法2005
- Inventor(s)
  入江一浩, 他5名
- Industrial Property Rights Holder
  入江一浩, 他5名
- Industrial Property Number
  2005-087184
- Filing Date
  2005-03-24
- Data Source
  KAKENHI-PROJECT-16380080
[Presentation] アミロイドβの3量体モデルに用いる3回対称型トリスアミノ酸リンカーの合成研究2024
- Author(s)
  内野歩美、塚野千尋、入江一浩
- Organizer
  日本農芸化学会2024年度大会（東京）
- Data Source
  KAKENHI-PROJECT-23H00325
[Presentation] CH/π相互作用に着目した10, 12-dimethyl-aplog-1の抗がん剤シードとしての構造最適化2023
- Author(s)
  青木眞子、小林巧実、入江一浩、塚野千尋
- Organizer
  第52回複素環討論会、東北大学(仙台市)
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] 毒性アミロイドβの立体構造に立脚した抗体開発2023
- Author(s)
  景山裕介、入江由美、松島由佳、瀬川辰也、喜田昭子、赤津祐康、金田大太、橋詰良夫、入江一浩、遠山育夫
- Organizer
  第12回日本認知症予防学会
- Invited
- Data Source
  KAKENHI-PROJECT-23H00325
[Presentation] Synthesis and characterization of dimer and trimer models of amyloid β tethered at the C-terminal region2023
- Author(s)
  Irie Kazuhiro
- Organizer
  6th International Symposium of Kyoto Biomolecular Mass Spectrometry Society (Kyoto)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H00921
[Presentation] 天然PKCリガンドとともに40年 - 医薬品シーズを志向した構造単純化2023
- Author(s)
  入江一浩
- Organizer
  Visionary農芸化学100シンポジウム、天然物化学4.0、東北大学青葉山キャンパス(仙台市)
- Invited
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] アロタケタール類の共通基本骨格をもつ単純化アナログの立体異性体の系統的合成とPKC結合活性2023
- Author(s)
  奥田創元、塚野千尋、入江一浩
- Organizer
  日本農芸化学会関西支部第524回講演会(京都、オンライン開催)
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] Vibsanin AとプロテインキナーゼC C1ドメインとの結合様式の解析2023
- Author(s)
  畠中聡之、柳田亮、大谷真緒、花木祐輔、佐藤正資、川浪康弘、入江一浩
- Organizer
  2023年度日本農芸化学会大会(広島、オンライン開催)
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] アミロイドβ40の平行β-シート型3量体モデルの構造最適化2023
- Author(s)
  内野歩美、入江由美、筑後文馨、塚野千尋、牧俊人、久米利明、景山裕介、遠山育夫、入江一浩
- Organizer
  2023年度日本農芸化学会大会（オンライン開催）
- Data Source
  KAKENHI-PROJECT-19H00921
[Presentation] Aplysiatoxin単純化アナログ・10-Me-Aplog-1のリン酸化体のLRA活性と薬物動態2023
- Author(s)
  眞木準平、花木祐輔、柳田亮、菊森将之、鷲崎彩夏、塚野千尋、明里宏文、入江一浩
- Organizer
  2023年度日本農芸化学会大会(広島、オンライン開催)
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] 側鎖の構造活性相関を目的とした抗がん剤シーズ・10, 12-dimethyl-aplog-1の改良合成法の開発2023
- Author(s)
  青木眞子、塚野千尋、入江一浩
- Organizer
  2023年度日本農芸化学会大会(広島、オンライン開催)
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] アミロイドβ40の毒性２および３量体モデルの構造最適化2023
- Author(s)
  入江一浩、内野歩美、筑後文馨、入江由美、塚野千尋、川瀬泰司、廣瀬賢治、景山裕介、遠山育夫、柳田亮、牧俊人、久米利明
- Organizer
  第65回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-23H00325
[Presentation] 長鎖ポリアミンにより翻訳後修飾を受けたペプチド毒aculeine 類の合成研究2022
- Author(s)
  入江樂、宮原正義、高木紗羅、若林稜也、谷知恵、松永智子、入江由美、稲井誠、大内仁志、入江一浩、酒井隆一、菅敏幸、及川雅人
- Organizer
  第64回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-23K23478
[Presentation] Toxic amyloid β42 conformer may accelerate the onset of Alzheimer's disease in the preclinical stage2022
- Author(s)
  Futamura Akinori、Hieda Sotaro、Mori Yukiko、Kasuga Kensaku、Sugimoto Azusa、Kasai Hideyo、Kuroda Takeshi、Yano Satoshi、Tsuji Mayumi、Ikeuchi Takeshi、Irie Kazuhiro、Ono Kenjiro
- Organizer
  第63回日本神経学会学術集会（東京）
- Data Source
  KAKENHI-PROJECT-19H00921
[Presentation] アロタケタール類のシスピラン環型単純化アナログの合成とPKC結合活性2022
- Author(s)
  奥田創元、塚野千尋、柳田亮、入江一浩
- Organizer
  2022年度日本農芸化学会大会（京都）オンライン開催
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] アミロイドβの毒性配座を基盤としたアルツハイマー病の早期診断法の開発2022
- Author(s)
  入江一浩
- Organizer
  Visionary農芸化学100シンポジウム（京都）
- Invited
- Data Source
  KAKENHI-PROJECT-19H00921
[Presentation] Synthetic studies on aculeines, peptide toxins post-translationally modified by long-chain polyamines2022
- Author(s)
  Raku Iriea, Sara Takaki, Ryoya Wakabayashi, Chisato Tani, Hitoshi Ouchi, Makoto Inai, Toshiyuki Kan, Masato Oikawa
- Organizer
  ICPAC Kota Kinabalu 2022
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23478
[Presentation] アロタケタール類のトランスデカリン型単純化アナログの合成とPKC結合活性2022
- Author(s)
  眞木準平、押村亜沙美、塚野千尋、柳田亮、入江一浩
- Organizer
  2022年度日本農芸化学会大会（京都）オンライン開催
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] 3回対称ならびに平行型Aβ40の3量体モデルの合成と機能解析2022
- Author(s)
  内野歩美、入江由美、塚野千尋、川瀬泰司、廣瀬賢治、入江一浩
- Organizer
  2022年度日本農芸化学会大会（京都）（オンライン開催）
- Data Source
  KAKENHI-PROJECT-19H00921
[Presentation] アミロイドβの毒性配座を標的とした立体構造特異抗体の開発とAD診断2022
- Author(s)
  入江一浩
- Organizer
  第11回日本認知症予防学会学術集会（福岡）
- Invited
- Data Source
  KAKENHI-PROJECT-19H00921
[Presentation] (-)-Carvoneを用いるAplysiatoxin単純化アナログの合成と活性評価2022
- Author(s)
  鈴木芳幸、守時恵一、梶原瑞生、柳田亮、川浪康弘、花木祐輔、入江一浩
- Organizer
  2022年度日本農芸化学会大会（京都）オンライン開催
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] 天然PKCリガンドによる化学コミュニケーションの統合的理解と医薬品シーズの開発2022
- Author(s)
  入江一浩
- Organizer
  新学術領域研究(化学コミュニ)第10回公開シンポジウム、京都大学・藤多記念ホール(京都市)
- Invited
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] Development of a conformation specific antibody identifying toxic conformation of amyloid β peptide2022
- Author(s)
  Kageyama Yusuke、Irie Yumi、Matsushima Yuka、Segawa Tatsuya、Kaneda Daita、Hashizume Yoshio、Akatsu Hiroyasu、Miki Kunio、Kita Akiko、Irie Kazuhiro、Tooyama Ikuo
- Organizer
  第63回日本神経病理学会総会学術研究会（京都）
- Data Source
  KAKENHI-PROJECT-19H00921
[Presentation] 抗Aβオリゴマー抗体・24B3の毒性配座認識機構の解析2022
- Author(s)
  入江由美、松島由佳、喜田昭子、三木邦夫、瀬川辰也、前田雅弘、柳田亮、入江一浩
- Organizer
  第41回日本認知症学会学術集会、第37回日本老年精神医学会（合同開催）（東京）
- Data Source
  KAKENHI-PROJECT-19H00921
[Presentation] B環を除去したAplysiatoxin単純化アナログの合成と生物活性2022
- Author(s)
  関戸智紀、山本剛史、柳田亮、花木祐輔、川浪康弘、入江一浩
- Organizer
  2022年度日本農芸化学会大会（京都）オンライン開催
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] アミロイドβの毒性２量体モデルにおけるリンカー長の凝集能と細胞毒性に及ぼす影響2022
- Author(s)
  筑後文馨、入江由美、内野歩美、塚野千尋、川瀬泰司、廣瀬賢治、入江一浩
- Organizer
  2022年度日本農芸化学会大会（京都）（オンライン開催）
- Data Source
  KAKENHI-PROJECT-19H00921
[Presentation] アロタケタール単純化アナログの設計・合成およびPKC結合活性2022
- Author(s)
  眞木準平、押村亜沙美、塚野千尋、柳田亮、齋藤裕、榊原康文、入江一浩
- Organizer
  第51回複素環化学討論会、大阪大学コンベンションセンター(吹田市)
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] 病原性凝集ペプチドの3量体モデルのリンカーとなるアルキル架橋トリス-α-アミノ酸の合成2021
- Author(s)
  内野歩美、塚野千尋、今本恒雄、入江一浩
- Organizer
  日本農芸化学会2021年度大会（オンライン開催）
- Data Source
  KAKENHI-PROJECT-19H00921
[Presentation] CH/π相互作用に着目したAplysiatoxin単純化アナログの分子動力学解析2021
- Author(s)
  柳田亮、小林巧美、権田敦子、高田晃児、入江一浩
- Organizer
  日本農芸化学会2021年度大会（オンライン開催）
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] Synthesis and biological activities of des-A-ring analog of 18-deoxy-aplog-1, a simplified analog of debromoaplysiatoxin2021
- Author(s)
  Yanagita Ryo C.、Ashida Yoshiki、Kawanami Yasuhiro、Okamoto Mutsumi、Dan Shingo、Irie Kazuhiro
- Organizer
  2021 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2021) virtual
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] Development of new protein kinase C ligands using a machine learning model2021
- Author(s)
  Irie Kazuhiro、Tsukano Chihiro、Maki Jumpei、Oshimura Asami、Okuda Sogen、Gonda Atsuko、Yanagita Ryo C.、Saito Yutaka、Sakakibara Yasubumi
- Organizer
  2021 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2021) virtual
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] 分子内ジスルフィド結合形成によるアミロイドβ42の毒性配座モデルの最適化2021
- Author(s)
  松島由佳、入江一浩
- Organizer
  日本農芸化学会関西支部例会（第514回講演会、オンライン開催）
- Data Source
  KAKENHI-PROJECT-19H00921
[Presentation] Toxic amyloid β42 conformer may accelerate the onset of Alzheimer's disease in the preclinical stage2021
- Author(s)
  二村明徳、稗田宗太郎、森友紀子、春日健作、杉本あずさ、笠井英世、黒田岳志、矢野怜、辻まゆみ、池内　健、入江一浩、小野賢二郎
- Organizer
  第40回日本認知症学会学術集会（オンデマンド配信）
- Data Source
  KAKENHI-PROJECT-19H00921
[Presentation] 分子内ジスルフィド結合形成によるアミロイド β42毒性配座固定モデルの合成および活性評価2021
- Author(s)
  松島由佳、柳田　亮、入江一浩
- Organizer
  第39回日本認知症学会学術集会（オンライン開催）
- Data Source
  KAKENHI-PROJECT-19H00921
[Presentation] Suppression of toxic amyloid β42 oligomers in rat primary cerebral cortex cells and human iPS-derived neurons treated with 10-Me-Aplog-1, a new PKC activator2021
- Author(s)
  Murakami Kazuma、Yoshimura Mayuko、Nakagawa Shota、Kume Toshiaki、Kondo Takayuki、Inoue Haruhisa、Irie Kazuhiro
- Organizer
  2021 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2021) virtual
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] B環を除去したAplysiatoxin単純化アナログの合成研究2021
- Author(s)
  山本剛資、柳田　亮、川浪康弘、入江一浩
- Organizer
  日本農芸化学会中四国支部第58回講演会（オンライン開催）
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] CH/π相互作用に着目したaplysiatoxin単純化アナログの合成と生物活性2020
- Author(s)
  小林巧実、入江一浩
- Organizer
  2020年度日本農芸化学会大会（九州大学、福岡市）
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] Debromoaplysiatoxin単純化アナログ・10-Me-Aplog-1の側鎖長の最適化2020
- Author(s)
  権田敦子、高田晃児、入江一浩
- Organizer
  2020年度日本農芸化学会大会（九州大学、福岡市）
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] Synthesis, conformation, and biological activities of a des-A-ring analog of 18-deoxy-aplog-1, a simplified analog of debromoaplysiatoxin2019
- Author(s)
  Ashida Yoshiki、Yanagita Ryo C.、Kawanami Yasuhiro、Okamura Mutsumi、Dan Shingo、Irie Kazuhiro
- Organizer
  新学術領域研究「化学コミュニケーションのフロンティア」第1回国際シンポジウム（一橋大学一橋講堂、東京）
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] アミロイドβの毒性配座理論を基盤としたアルツハイマー病の予防戦略2019
- Author(s)
  入江一浩
- Organizer
  日本農芸化学会東北支部2019年度大会（弘前大学、弘前市）
- Invited
- Data Source
  KAKENHI-PROJECT-19H00921
[Presentation] 分子内ジスルフィド結合によるアミロイドβ 42の毒性配座固定アナログの合成と生化学的機能解析2019
- Author(s)
  松島由佳、村上一馬、入江一浩
- Organizer
  第9回認知症研究を知る若手研究者の集まり(ホテルヘリテイジ・リゾート、熊谷市）
- Data Source
  KAKENHI-PROJECT-19H00921
[Presentation] 新規PKCリガンドの開発とHIVのShock & Kill療法への応用2019
- Author(s)
  入江一浩
- Organizer
  新学術領域研究（化学コミュニ）第6回公開シンポジウム（慶應義塾大学、横浜市）
- Invited
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] スピロ環を簡略化したアプリシアトキシン単純化アナログの合成，配座，および生物活性2019
- Author(s)
  柳田亮、芦田能基、川浪康弘、旦慎吾、岡村睦美、入江一浩
- Organizer
  2018年度先端モデル動物支援プラットフォーム成果発表会（琵琶湖ホテル、大津市）
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] 準安定なアミロイドβの毒性オリゴマーモデルの合成と機能解析2019
- Author(s)
  入江由美、村上一馬、花木瑞穂、花木祐輔、鈴木天志、今本恒雄、古田　巧、川端猛夫、川瀬泰司、廣瀬賢治、柳田　亮、入江一浩
- Organizer
  第61回天然有機化合物討論会（広島国際会議場、広島市）
- Data Source
  KAKENHI-PROJECT-19H00921
[Presentation] アミロイドβ40の3量体モデルの合成と神経細胞毒性2019
- Author(s)
  入江由美、花木瑞穂、村上一馬、今本恒雄、古田　巧、川端猛夫、川瀬泰司、廣瀬賢治、柳田　亮、入江一浩
- Organizer
  第38回日本認知症学会学術集会（京王プラザホテル、東京）
- Data Source
  KAKENHI-PROJECT-19H00921
[Presentation] アミロイドβの毒性配座理論を基盤としたアルツハイマー病の予防戦略2019
- Author(s)
  入江一浩
- Organizer
  2019年度日本農芸化学会大会（東京農大、東京）日本農芸化学会賞受賞講演
- Invited
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] PKC活性化剤とBET阻害剤の併用によるHIV再活性化能及び毒性への効果2019
- Author(s)
  鷲崎彩夏、村田めぐみ、関　洋平、Yin Pui Tang、Tan Wei Keat、入江一浩、明里宏文
- Organizer
  第33回日本エイズ学会学術集会・総会（熊本城ホール、熊本市）
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] アミロイドβの毒性配座理論を基盤としたアルツハイマー病の予防戦略2019
- Author(s)
  入江一浩
- Organizer
  2019年度日本農芸化学会大会（東京農大、東京）日本農芸化学会賞受賞講演
- Invited
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] スピロ環をもたないaplysiatoxin単純化アナログの合成とPKCアイソザイム結合活性2019
- Author(s)
  押村亜沙美、早川皓太郎、花木祐輔、柳田亮、入江一浩
- Organizer
  2019年度日本農芸化学会大会（東京農大、東京）
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] アミロイドβの毒性配座理論を基盤としたアルツハイマー病の予防戦略2019
- Author(s)
  入江一浩
- Organizer
  日本農芸化学会関西・中部支部2019年度合同神戸大会（神戸大学、神戸市）
- Invited
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] サンゴジュの花芽に含まれるビブサニン類の分析と生物活性評価2019
- Author(s)
  柳田亮、植松紗和子、西皓冬、川浪康弘、入江一浩
- Organizer
  2019年度日本農芸化学会大会（東京農大、東京）
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] 分子内ジスルフィド結合形成によるアミロイドβ42の毒性配座モデルの合成と機能解析2019
- Author(s)
  松島由佳、村上一馬、花木瑞穂、粟野達也、高部圭司、柳田亮、入江一浩
- Organizer
  2019年度日本農芸化学会大会（東京農大、東京）
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アミロイドβの毒性配座理論を基盤としたアルツハイマー病の予防戦略2019
- Author(s)
  入江一浩
- Organizer
  日本農芸化学会関西・中部支部2019年度合同神戸大会（神戸大学、神戸市）
- Invited
- Data Source
  KAKENHI-PROJECT-19H00921
[Presentation] Evaluation system of amyloid beta precursor protein processing in rat primary cortical neurons treated with PKC activators2019
- Author(s)
  Yoshimura Mayuko、Murakami Kazuma、Kume Toshiaki、Irie Kazuhiro
- Organizer
  新学術領域研究「化学コミュニケーションのフロンティア」第1回国際シンポジウム（一橋大学一橋講堂、東京）
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] アミロイドβの凝集を抑制する食品・生薬成分の作用機構2019
- Author(s)
  入江一浩、村上一馬
- Organizer
  2019年度日本農芸化学会大会（東京農大、東京）
- Invited
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アミロイドβの毒性配座理論を基盤としたアルツハイマー病の予防戦略2019
- Author(s)
  入江一浩
- Organizer
  日本農芸化学会東北支部2019年度大会（弘前大学、弘前市）
- Invited
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] アミロイドβ42の毒性オリゴマーに対する核酸アプタマーの開発研究と脳組織染色への応用2019
- Author(s)
  村上一馬、小畑弥生、関川あさ、上田遥、泉尾直孝、粟野達也、高部圭司、清水孝彦、入江一浩
- Organizer
  2019年度日本農芸化学会大会（東京農大、東京）優秀発表
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アミロイドβの毒性オリゴマーの構造解析に基づくアルツハイマー病の早期診断法の開発2018
- Author(s)
  入江一浩
- Organizer
  2018年度日本農芸化学会大会（名城大学、名古屋市）
- Invited
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] A Novel PKC activator 10-methyl-aplog-1 in combination with JQ1 showed high potency as LRA for shock and kill therapy2018
- Author(s)
  Washizaki Ayaka、Murata Megumi、Seki Yohei、Yin Pui Tang、Kangawa Hiroyuki、Tan Wei Keat、Irie Kazuhiro、Akari Hirofumi
- Organizer
  36th Annual Symposium on Nonhuman Primate Models for AIDS (Bell Harbor International Conference Center, Washington, USA)
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] 新規PKC活性化剤10-Methyl-Aplog-1とJQ1の併用はLatency Reversing Agentとして理想的な活性を示す2018
- Author(s)
  鷲崎彩夏、村田めぐみ、関洋平、Yin Pui Tang、寒川裕之、Tan Wei Keat、入江一浩、明里宏文
- Organizer
  第32回日本エイズ学会学術集会・総会（大阪国際会議場・大阪市中央公会堂、大阪市）
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] アミロイドβ42の毒性2量体モデルから形成されるプロトフィブリルを標的としたRNAアプタマーの開発2018
- Author(s)
  小畑弥生、村上一馬、関川あさ、入江一浩
- Organizer
  2018年度日本農芸化学会大会（名城大学、名古屋市）
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] 抗腫瘍性Aplysiatoxin単純化アナログ・10-Me-Aplog-1のアセタール型アナログの合成と生物活性2018
- Author(s)
  早川皓太郎、花木祐輔、徳田春邦、柳田亮、中川優、入江一浩
- Organizer
  第60回天然有機化合物討論会（久留米シティープラザ、福岡県久留米市）
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] アプリシアトキシン単純化アナログ・10-Me-aplog-1の側鎖誘導体の合成と活性2018
- Author(s)
  高田晃児、花木祐輔、菊森将之、徳田春邦、柳田亮、入江一浩
- Organizer
  2018年度日本農芸化学会大会（名城大学、名古屋市）
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] スピロ環をもたないアプリシアトキシン単純化アナログの合成、配座、および活性2018
- Author(s)
  芦田能基、柳田亮、川浪康弘、入江一浩
- Organizer
  2018年度日本農芸化学会大会（名城大学、名古屋市）
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] アミロイドβ42の2量体モデル由来の毒性オリゴマーに対するRNAアプタマー2018
- Author(s)
  小畑弥生、村上一馬、関川あさ、粟野達也、髙部圭司、入江一浩
- Organizer
  日本核酸医薬学会第4回年会（九州大学医学部百年講堂、福岡市）
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アポモルフィンによるアミロイドβ42凝集抑制機構の解析2018
- Author(s)
  花木瑞穂、村上一馬、片山寿美枝、赤木謙一、入江一浩
- Organizer
  2018年度日本農芸化学会大会（名城大学、名古屋市）
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] RNA aptamers targeting the toxic oligomers of Aβ42 and their application to immunohistochemistry2018
- Author(s)
  Murakami Kazuma、Obata Yayoi、Sekikawa Asa、Ueda Haruka、Izuo Naotaka、Awano Tatsuya、Takabe Keiji、Shimizu Takahiko、Irie Kazuhiro
- Organizer
  The 45th International Symposium on Nucleic Acids Chemistry (Kyoto University Clock Tower Centennial Hall, Kyoto, Japan)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] 分子内ジスルフィド結合形成によるアミロイドβの毒性コンホメーションの制御2018
- Author(s)
  松島由佳、村上一馬、花木瑞穂、粟野達也、高部圭司、柳田亮、入江一浩
- Organizer
  第37回日本認知症学会学術集会（ロイトン札幌・札幌市教育文化会館、札幌市）
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アプリシアトキシン単純化アナログ・10-Me-Aplog-1の構造最適化とがん細胞増殖抑制に関わるPKCアイソザイムの同定2018
- Author(s)
  入江一浩
- Organizer
  新学術領域研究「化学コミュニケーションのフロンティア」第2回公開シンポジウム（益川ホール、京都市）
- Invited
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] 青ジソに含まれるアミロイドβ42の凝集阻害物質の作用機構とマウスにおける生体内代謝2018
- Author(s)
  坂口嘉紀、村上一馬、花木瑞穂、泉尾直孝、小澤祐介、粟野達也、高部圭司、川瀬泰司、廣瀬賢治、三羽伸明、久米利明、清水孝彦、入江一浩
- Organizer
  2018年度日本農芸化学会大会（大会トピックス賞）（名城大学、名古屋市）
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アプリシアトキシン単純化アナログのがん細胞増殖抑制活性2018
- Author(s)
  入江一浩
- Organizer
  先端モデル動物支援プラットフォーム　成果発表会2017（琵琶湖ホテル、大津市）
- Invited
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] アプリシアトキシン単純化アナログ・10-Me-Aplog-1の3位アセタール型アナログの合成2018
- Author(s)
  早川皓太郎、花木祐輔、徳田春邦、柳田亮、中川優、入江一浩
- Organizer
  2018年度日本農芸化学会大会（名城大学、名古屋市）
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] サンゴジュに含まれるビブサニン類のプロテインキナーゼC結合活性の評価と結合様式の予測2018
- Author(s)
  植松紗和子、柳田亮、三宅翔太、川浪康弘、入江一浩
- Organizer
  日本農芸化学会2018年度中四国支部大会（島根大学松江キャンパス、松江市）
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] Aplysiatoxin 単純化アナログ・10-Methyl-aplog-1のがん細胞増殖抑制に関わるPKCアイソザイムの同定2018
- Author(s)
  花木祐輔、四方雄貴、菊森将之、堀田夏紀、井本正哉、入江一浩
- Organizer
  2018年度日本農芸化学会大会（名城大学、名古屋市）
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] アミロイドβの毒性配座理論と抗体創製2017
- Author(s)
  村上一馬、入江一浩
- Organizer
  認知症研究を知る若手研究者の集まり2017（湯の宿木もれび、大津市）
- Invited
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] 神経細胞毒性を有する準安定なアミロイドβの2量体モデルの合成とイオンモビリティー質量分析法による構造解析2017
- Author(s)
  入江一浩、入江由美、村上一馬、花木瑞穂、花木祐輔、川瀬泰司、廣瀬賢治、徳田隆彦、前田雅弘
- Organizer
  第35回メディシナルケミストリーシンポジウム（豊田講堂、名古屋市）
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] 新規PKC activator、10-Methyl-Aplog-1はHIV-1を再活性化する有用なLatency Reversing Agentである2017
- Author(s)
  鷲崎彩夏、村田めぐみ、関洋平、Yin Pui Tang、寒川裕之、入江一浩、明里宏文
- Organizer
  第31回日本エイズ学会学術集会・総会（中野サンプラザ、東京都）
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] 新規PKC activatorである10-methyl-aplog-1はHIV-1再活性化薬として有用である2017
- Author(s)
  鷲崎彩夏、村田めぐみ、関洋平、Yin Pui Tang、寒川裕之、入江一浩、明里宏文
- Organizer
  第65回日本ウイルス学会学術集会（大阪国際会議場、大阪市）
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] アミロイドβ「毒性コンホマー」を標的にしたアルツハイマー病の治療・診断法の開発2017
- Author(s)
  泉尾直孝、久米利明、村上一馬、徳田隆彦、前田雅弘、入江一浩、清水孝彦
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2017-03-25
- Invited
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] A Novel PKC activator, 10-methyl-aplog-1, induces HIV-1 efficiently in combination with BET inhibitor JQ12017
- Author(s)
  Ayaka Washizaki, Megumi Murata, Yohei Seki, Yin Pui Tang, Kazuhiro Irie, Hirofumi Akari
- Organizer
  35th Annual Symposium on Nonhuman Primate Models for AIDS (Madison, USA)
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] 漢方由来ウンカリン酸 C によるアミロイド β42 核形成阻害メカニズム2017
- Author(s)
  吉岡卓也、村上一馬、花木瑞穂、緑川諭弘、谷脇慎治、郡司祐樹、川瀬泰司、廣瀬賢治、入江一浩
- Organizer
  2017年度日本農芸化学会大会
- Place of Presentation
  京都女子大学（京都府京都市）
- Year and Date
  2017-03-20
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] 生薬チョウトウコウに含まれるアミロイドβオリゴマー形成阻害物質の同定と作用機構2017
- Author(s)
  村上一馬、吉岡卓也、井戸恭平、花木瑞穂、山口加乃子、緑川諭弘、谷脇慎治、郡司祐樹、赤木謙一、川瀬泰司、廣瀬賢治、入江一浩
- Organizer
  第59回天然有機化合物討論会（札幌市民ホール、札幌市）
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] イオンモビリティー質量分析計を用いたアミロイドβオリゴマーの測定2017
- Author(s)
  入江一浩
- Organizer
  第65回質量分析総合討論会（つくば国際会議場、つくば市）
- Invited
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アミロイドβ40の毒性オリゴマーモデル2017
- Author(s)
  入江由美、村上一馬、花木瑞穂、花木祐輔、鈴木天志、物部容子、高井朋代、赤木謙一、川瀬泰司、廣瀬賢治、入江一浩
- Organizer
  2017年度日本農芸化学会大会
- Place of Presentation
  京都女子大学（京都府京都市）
- Year and Date
  2017-03-20
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] オリゴマー仮説の視点からバイオマーカーを考える：アミロイドβの毒性配座理論2017
- Author(s)
  村上一馬、入江一浩
- Organizer
  第36回日本認知症学会学術集会（ANAクラウンプラザホテル金沢、金沢市）
- Invited
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アミロイドβの毒性2量体モデルの合成とイオンモビリティー質量分析法による構造解析2017
- Author(s)
  入江一浩
- Organizer
  京都大学学際融合教育研究推進センター・生理化学研究ユニット第7回公開シンポジウム（京都大学農学部総合館、京都市）
- Invited
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] Aβ42の22-23位におけるターン構造はAβ42誘発神経毒性を調節する2016
- Author(s)
  泉尾直孝、久米利明、村上一馬、前田雅弘、入江一浩、清水孝彦
- Organizer
  日本基礎老化学会大会
- Place of Presentation
  伊勢原市民文化会館（神奈川県伊勢原市）
- Year and Date
  2016-05-27
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] Identification of the “toxic conformer” of amyloid β and its pathogenic contribution of Alzheimer's disease2016
- Author(s)
  Naotaka Izuo, Kazuma Murakami, Toshiaki Kume, Masahiro Maeda, Kazuhiro Irie, Takahiko Shimizu
- Organizer
  2016 Spring International Conference of the Korean Society for Gerontology
- Place of Presentation
  Convention Hall (Daegu, Korea)
- Year and Date
  2016-06-16
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アミロイドβのラジカル化：アルツハイマー病態におけるSOD1の役割2016
- Author(s)
  村上一馬、清水孝彦、入江一浩
- Organizer
  第11回レドックス・ライフイノベーションシンポジウム
- Place of Presentation
  お茶の水女子大学（東京都文京区）
- Year and Date
  2016-03-17
- Invited
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] Passive immunization with the toxic conformer of Aβ ameliorated behavioral abnormalities in Alzheimer’s-like model without affecting senile plaque deposition2016
- Author(s)
  泉尾直孝、村上一馬、久米利明、入江一浩、横手幸太郎、清水孝彦
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-10
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] 天然ポリフェノールによるAβ42凝集阻害機構の解明とアルツハイマー病予防の可能性2016
- Author(s)
  村上一馬、入江一浩
- Organizer
  第35回日本認知症学会学術集会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Year and Date
  2016-12-03
- Invited
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] ウンカリン酸によるアミロイドβ凝集核形成の選択的阻害2016
- Author(s)
  吉岡卓也、村上一馬、井戸恭平、花木瑞穂、山口加乃子、緑川諭弘、谷脇慎治、郡司祐樹、入江一浩
- Organizer
  第35回日本認知症学会学術集会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Year and Date
  2016-12-02
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] チョウトウコウに含まれるウンカリン酸Ｃおよびその誘導体のアミロイドβ凝集阻害活性2016
- Author(s)
  吉岡卓也、村上一馬、花木瑞穂、緑川諭弘、谷脇慎治、郡司裕樹、入江一浩
- Organizer
  2016年度日本農芸化学会大会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2016-03-28
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アミロイドβの毒性コンホマーにきわめて特異的な抗体の開発とアルツハイマー病診断への応用2016
- Author(s)
  村上一馬、徳田真樹、鈴木天志、入江由美、花木瑞穂、柳田亮、物部容子、赤木謙一、石井亮太郎、建部陽嗣、徳田隆彦、前田雅弘、久米利明、泉尾直孝、清水孝彦、入江一浩
- Organizer
  2016年度日本農芸化学会大会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2016-03-28
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アミロイドβ40の2量体モデルの合成と神経細胞毒性2016
- Author(s)
  入江由美、村上一馬、鈴木天志、花木瑞穂、花木祐輔、物部容子、高井朋代、赤木謙一、入江一浩
- Organizer
  第35回日本認知症学会学術集会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Year and Date
  2016-12-02
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] Characterization of the monoclonal antibody (24B3) highly recognizing the toxic turn of amyloid β42 and its application to diagnosis for Alzheimer’s disease2016
- Author(s)
  Kazuma Murakami, Mizuho Hanaki, Maki Tokuda, Ken-ichi kagi, Ryotaro Ishii, Harutsugu Tatebe, Takahiko Tokuda, Masahiro Maeda, Naotaka Izuo, Takahiko Shimizu, Kazuhiro Irie
- Organizer
  The 8th Takeda Science Foundation Symposium on PharmaSciences “Biomolecule-based Medicinal Science: Featuring Mid-Size Drugs”
- Place of Presentation
  Takeda Pharmaceutical Company, Ltd. (Suita, Japan)
- Year and Date
  2016-01-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アミロイドβ42ダイマーの合成と活性評価2015
- Author(s)
  徳田真樹、村上一馬、鈴木天志、花木瑞穂、岩崎真実、久米利明、入江一浩
- Organizer
  2015年度日本農芸化学会大会
- Place of Presentation
  岡山大学津島キャンパス（岡山市）
- Year and Date
  2015-03-27
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] Aβ 毒性コンホマーの選択的除去は老人斑に影響せずアルツハイマー病症状を改善する2015
- Author(s)
  泉尾直孝、村上一馬、前田雅弘、久米利明、横手幸太郎、入江一浩、清水孝彦
- Organizer
  第34回日本認知症学会学術集会
- Place of Presentation
  リンクステーションホール青森（青森県青森市）
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アミロイドβの「毒性コンホマー」を標的とした受動免疫療法はアルツハイマー病モデルの神経症状を改善する2015
- Author(s)
  泉尾直孝、村上一馬、徳田隆彦、久米利明、赤池昭紀、白澤卓二、横手幸太郎、入江一浩、清水孝彦
- Organizer
  日本基礎老化学会大会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2015-06-13
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アミロイドβの毒性配座理論に基づいた構造特異抗体の開発と診断薬への応用2015
- Author(s)
  村上一馬、入江一浩
- Organizer
  第8回たんぱく質の異常凝集とその防御・修復機構に関する研究会
- Place of Presentation
  京都大学原子炉実験所（大阪府熊取町）
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] Aplysiatoxin 単純化アナログのアミド誘導体の合成と活性2015
- Author(s)
  花木祐輔、柳田　亮、菅原貴弘、相田美砂子、徳田春邦、鈴木信孝、入江一浩
- Organizer
  2015年度日本農芸化学会大会
- Place of Presentation
  岡山大学津島キャンパス（岡山市）
- Year and Date
  2015-03-27
- Data Source
  KAKENHI-PLANNED-23102011
[Presentation] Pathophysiological activities of the “toxic conformer” and the “non-toxic conformer” of amyloid β-induced neurotoxicity2015
- Author(s)
  泉尾直孝、久米利明、村上一馬、入江一浩、泉安彦、赤池昭紀、横手幸太郎、清水孝彦
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋国際会議場（名古屋市）
- Year and Date
  2015-03-19
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アミロイドβペプチドの毒性配座理論に基づいた構造特異抗体の開発と診断薬への応用2015
- Author(s)
  村上一馬、入江一浩
- Organizer
  第47回若手ペプチド夏の勉強会
- Place of Presentation
  信州塩尻・天然温泉アスティかたおか（長野県塩尻市）
- Year and Date
  2015-08-11
- Invited
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] Structural insight into the inhibitory mechanism of amyloid β42 aggregation by non-catechol-type flavonoids2015
- Author(s)
  Mizuho Hanaki, Kazuma Murakami, Ken-ichi Akagi, Kazuhiro Irie
- Organizer
  2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015)
- Place of Presentation
  Hilton Hawaiian Villege (Honolulu, USA)
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] Aβ毒性コンホマーの選択的除去は老人班蓄積を阻害せずにアルツハイマー病モデルマウスの行動異常を改善する2015
- Author(s)
  泉尾直孝、村上一馬、前田雅弘、久米利明、横手幸太郎、入江一浩、清水孝彦
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-04
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] Inhibitory mechanism for amyloid β42 aggregation by flavonoids2015
- Author(s)
  Kazuhiro Irie
- Organizer
  The 2nd Kyoto-Bordeaux Symposium 2015
- Place of Presentation
  Kyoto University (Kyoto, Japan)
- Year and Date
  2015-05-22
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] SOFAST-HMQC NMR を用いた非カテコール型フラボノイドによるアミロイドβの凝集抑制機構の解析2015
- Author(s)
  花木瑞穂、村上一馬、赤木謙一、入江一浩
- Organizer
  2015年度日本農芸化学会中部・関西支部合同大会
- Place of Presentation
  富山県立大学（富山県射水市）
- Year and Date
  2015-09-20
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] Characterization of monoclonal antibodies against the toxic turn of amyloid β42 and their application to diagnosis for Alzheimer’s disease2015
- Author(s)
  Kazuma Murakami, Mizuho Sato-Hanaki, L. M. Moro, G. Giaccone, F. Tagliavini, Ken-ichi Akagi, Ryotaro Ishii, Takahiko Tokuda, Masahiko Maeda, Naotaka Izuo, Takahiko Shimzu, Kazuhiro Irie
- Organizer
  2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015)
- Place of Presentation
  Hilton Hawaiian Villege (Honolulu, USA)
- Year and Date
  2015-12-15
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] 非カテコール型フラボノイドによるアミロイドβの凝集抑制機構2015
- Author(s)
  花木瑞穂、村上一馬、赤木謙一、入江一浩
- Organizer
  第57回天然有機化合物討論会
- Place of Presentation
  神奈川県民ホール（神奈川県横浜市）
- Year and Date
  2015-09-09
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アミロイドβの毒性コンホマーを極めて特異的に認識する抗体の開発とAD診断への応用2015
- Author(s)
  村上一馬、花木瑞穂、赤木謙一、石井亮太郎、徳田隆彦、前田雅弘、泉尾直孝、清水孝彦、入江一浩
- Organizer
  第34回日本認知症学会学術集会
- Place of Presentation
  リンクステーションホール青森（青森県青森市）
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アプリシアトキシンの構造単純化による抗がん剤シーズの開発研究2015
- Author(s)
  入江一浩
- Organizer
  第33回メディシナルケミストリーシンポジウム
- Place of Presentation
  幕張国際研修センター（千葉市）
- Year and Date
  2015-11-26
- Invited
- Data Source
  KAKENHI-PLANNED-23102011
[Presentation] Extraction of anti-proliferative activity from pleiotropic debromoaplysiatoxin, a potent tumor promoter and a highly inflammatory principle isolated from sea hare2015
- Author(s)
  K. Irie et al.
- Organizer
  2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015)
- Place of Presentation
  Hilton Hawaiian Village (Hawaii, USA)
- Year and Date
  2015-12-15
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23102011
[Presentation] AplysiatoxinのPKC C1ドメイン認識部位の構造活性相関研究2015
- Author(s)
  芦田能基、柳田　亮、川浪康弘、入江一浩
- Organizer
  2015年度日本農芸化学会大会
- Place of Presentation
  岡山大学津島キャンパス（岡山市）
- Year and Date
  2015-03-27
- Data Source
  KAKENHI-PLANNED-23102011
[Presentation] 天然のプロテインキナーゼＣリガンドの単純化による抗がん剤シーズの開発研究2015
- Author(s)
  入江一浩
- Organizer
  日本農芸化学会2015年度中四国・西日本支部合同大会
- Place of Presentation
  愛媛大学農学部（樽味キャンパス，松山市）
- Year and Date
  2015-09-17
- Invited
- Data Source
  KAKENHI-PLANNED-23102011
[Presentation] 抗がん剤開発を指向した新規プロテインキナーゼＣリガンドの創製2014
- Author(s)
  入江一浩
- Organizer
  京都大学学際融合教育研究推進センター・生理化学研究ユニット第4回公開シンポジウム
- Place of Presentation
  京都大学益川記念館（京都市）
- Year and Date
  2014-06-24
- Invited
- Data Source
  KAKENHI-PLANNED-23102011
[Presentation] アプリシアトキシン単純化アナログ（Aplog-1）の抗がん剤シーズとしての構造最適化2014
- Author(s)
  菊森将之、柳田　亮、中川　優、蒲池弘明、徳田春邦、鈴木信孝、入江一浩
- Organizer
  新学術領域研究・がん支援「化学療法基盤支援活動」第3回シンポジウム
- Place of Presentation
  万国津梁館（沖縄県、名護市）
- Year and Date
  2014-05-12
- Data Source
  KAKENHI-PLANNED-23102011
[Presentation] Synthesis and biological activities of the Abeta40 dimer with toxic conformation2014
- Author(s)
  Kazuhiro Irie, Kazuma Murakami, Takashi Suzuki, Mizuho Sato, Mami Iwasaki, Toshiaki Kume
- Organizer
  Alzheimer’s Association International Conference 2014
- Place of Presentation
  Bella Center A/S (Copenhagen, Denmark)
- Year and Date
  2014-07-14
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] 植物由来ポリフェノールのアミロイドβ凝集阻害活性2014
- Author(s)
  高瀬　澪、木立恵利、栗栖真奈美、竹田亜矢、中曽根理絵、宮前友策、村上一馬、入江一浩、繁森英幸
- Organizer
  新規素材探索研究会第13回セミナー
- Place of Presentation
  新横浜フジビューホテル、横浜
- Year and Date
  2014-06-06
- Data Source
  KAKENHI-PROJECT-24580156
[Presentation] Synthesis and biological activities of the simplified analogs of a natural PKC ligand aplysiatoxin2013
- Author(s)
  Kazuhiro irie
- Organizer
  International Symposium on Natural Products Chemistry and Chemical Biology 2013
- Place of Presentation
  , Nagoya, Japan
- Invited
- Data Source
  KAKENHI-ORGANIZER-23102001
[Presentation] 植物由来カフェ酸誘導体のアミロイドβ凝集阻害活性に関する研究2013
- Author(s)
  木立恵利、栗栖真奈美、宮前友策、村上一馬、入江一浩、繁森英幸
- Organizer
  第3回植物生理科学研究会
- Place of Presentation
  神戸天然物化学株式会社バイオリサーチセンター、神戸
- Data Source
  KAKENHI-PROJECT-24580156
[Presentation] Vitamin C and silymarin restores Aβ oligomerization and behavioral abnormality in Alzheimer's pathology2013
- Author(s)
  Murakami, K., Murata, N., Ozawa, Y., Irie, K., Shirasawa, T., Shimizu, T
- Organizer
  Alzheimer's Association International Conference (AAIC) 2013
- Place of Presentation
  Boston, USA
- Year and Date
  2013-07-15
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] ポリフェノールによるアミロイド β の凝集抑制機構2013
- Author(s)
  入江一浩
- Organizer
  2013年度日本農芸化学会大会シンポジウム
- Place of Presentation
  仙台
- Year and Date
  2013-03-27
- Invited
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] 植物由来カフェ酸誘導体のアミロイドβ凝集阻害活性に関する研究2013
- Author(s)
  木立恵利、栗栖真奈美、宮前友策、村上一馬、入江一浩、繁森英幸
- Organizer
  新規素材探索研究会第12回セミナー
- Place of Presentation
  新横浜フジビューホテル、横浜
- Data Source
  KAKENHI-PROJECT-24580156
[Presentation] 食品由来カフェオイルキナ酸の神経細胞保護効果2013
- Author(s)
  繁森英幸、宮前友策、栗栖真奈美、村上一馬、入江一浩、韓　準きゅ、礒田博子
- Organizer
  第11回日本機能性食品医用学会総会
- Place of Presentation
  東京海洋大学、東京
- Data Source
  KAKENHI-PROJECT-24580156
[Presentation] プロテインキナーゼＣを標的とした新規抗がん剤シーズ2012
- Author(s)
  入江　一浩
- Organizer
  京都大学新技術説明会（招待講演）
- Place of Presentation
  JST東京別館ホール（東京、市ヶ谷）
- Invited
- Data Source
  KAKENHI-ORGANIZER-23102001
[Presentation] Structure-activity studies of the simplified analogue of aplysiatoxin with antiproliferative activity like bryostatins2012
- Author(s)
  Kazuhiro Irie
- Organizer
  3rd International Symposium on Innovative Areas “Chemical Biology of Natural Products”
- Place of Presentation
  Kyoto Century Hotel (Kyoto)
- Year and Date
  2012-10-31
- Invited
- Data Source
  KAKENHI-PLANNED-23102011
[Presentation] 日本産フサコケムシに含まれるブリオスタチン類の同定と活性評価2012
- Author(s)
  植野紗代,柳田亮,村上一馬,村上明,徳田春邦,鈴木信孝,藤原健史,入江一浩
- Organizer
  日本農芸化学会2012年度大会
- Place of Presentation
  京都
- Year and Date
  2012-03-23
- Data Source
  KAKENHI-PROJECT-23658100
[Presentation] Research the inhibitory activity on amyloid-β aggregation of pheolic compounds2012
- Author(s)
  Eri Kidachi, Manami Kuisu, Yusaku Miyamae, Kazuma Muakami, Kazuhiro Irie, and Hideyuki Shigemori
- Organizer
  5th AG-BIO/PERDO Graduate Conference on Agricultural Biotechnology and KU-UT Joint Seminar II
- Place of Presentation
  Kasetsart University, Thailand
- Data Source
  KAKENHI-PROJECT-24580156
[Presentation] プロテインキナーゼＣを標的とした新規抗がん剤シーズ2012
- Author(s)
  入江　一浩
- Organizer
  京都大学新技術説明会
- Place of Presentation
  JST東京別館ホール（東京、市ヶ谷）
- Year and Date
  2012-08-24
- Invited
- Data Source
  KAKENHI-PLANNED-23102011
[Presentation] カテコール系フラボノイド類によるアミロイドβ の凝集抑制機構2012
- Author(s)
  村上一馬, 佐藤瑞穂, 井久保遥子, 宇野真弓, 中川優, 片山寿美枝, 赤木謙一, 増田裕一, 竹腰清乃理, 入江一浩
- Organizer
  第54回天然有機化合物討論会
- Place of Presentation
  東京
- Year and Date
  2012-09-19
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] 天然発がんプロモーターの骨格を利用した新規抗がん剤リードの開発2012
- Author(s)
  入江一浩
- Organizer
  2012年度日本農芸化学会大会
- Place of Presentation
  京都女子大学(京都市)(招待講演)
- Year and Date
  2012-03-25
- Data Source
  KAKENHI-PLANNED-23102011
[Presentation] Monoclonal antibody against a toxic conformer of Aβ42 with a turn at E22-D232012
- Author(s)
  Irie, K., Murakami, K., Horikoshi-Sakuraba, Y., Kinoshikta, N., Shirasawa, T., Shimizu, T., Tokuda, T
- Organizer
  Alzheimer's Association International Conference (AAIC) 2012
- Place of Presentation
  Vancouver, British Columbia, Canada
- Year and Date
  2012-07-15
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] ポリフェノールによるアミロイドβ の凝集阻害機構2012
- Author(s)
  入江一浩, 村上一馬, 佐藤瑞穂, 井久保遥子, 宇野真弓, 中川優, 片山寿美枝, 赤木謙一
- Organizer
  第31回日本認知症学会学術集会
- Place of Presentation
  つくば
- Year and Date
  2012-10-28
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] 抗がん剤開発を指向した新規PKCリガンドの創製と作用機構解析2012
- Author(s)
  入江一浩
- Organizer
  新学術領域研究「天然物ケミカルバイオロジー」第一回公開シンポジウム
- Place of Presentation
  大阪市立大学(大阪市)(招待講演)
- Year and Date
  2012-01-10
- Data Source
  KAKENHI-PLANNED-23102011
[Presentation] 天然発がんプロモーターの骨格を利用した新規ツール分子と抗がん剤シーズの開発2011
- Author(s)
  入江一浩
- Organizer
  日本農芸化学会関西支部例会(第472回講演会)
- Place of Presentation
  神戸大学(神戸市)(招待講演)
- Year and Date
  2011-12-10
- Data Source
  KAKENHI-PLANNED-23102011
[Presentation] Development of new molecular probes and therapeutic seeds having skeletons of naturallyoccumng tumor promoters2011
- Author(s)
  Kazuhiro Irie
- Organizer
  22nd French-Japanese Symposium of Medicinal and Fine Chemistry
- Place of Presentation
  Convention Center (Rouen, France)(招待講演)
- Year and Date
  2011-09-13
- Data Source
  KAKENHI-PLANNED-23102011
[Presentation] アミロイドβの毒性ターン構造を認識する抗体の開発2011
- Author(s)
  入江一浩
- Organizer
  第52回日本神経学会学術大会
- Place of Presentation
  国際会議場(名古屋市)(招待講演)
- Year and Date
  2011-05-19
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] Synthesis and structure-activity studies of the simplified analogue of aplysiatoxin with antiproliferative activity like bryostatin 12011
- Author(s)
  Kazuhiro Irie
- Organizer
  27th International Symposium on the Chemistry of Natural Products, 7th International Conference on Biodiversity
- Place of Presentation
  Convention Center (Brisbane, Australia)(招待講演)
- Year and Date
  2011-07-11
- Data Source
  KAKENHI-PLANNED-23102011
[Presentation] E22Δ mutation promotes the formation of toxic conformer in Alzheimer's peptide, Aβ422011
- Author(s)
  Murakami, K., Suzuki, T., Izuo, N., Kume, T., Akaike, A., Nagata, T., Nishizaki, T., Tomiyama, T., Takuma, H., Mori, H., Irie, K
- Organizer
  27th International Symposium on the Chemistry of Natural Products, 7th International Conference on Biodiversity
- Place of Presentation
  Brisbane, Australia
- Year and Date
  2011-07-11
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] アミロイドβ タンパクの毒性コンホメーションの同定と薬剤開発2011
- Author(s)
  入江一浩
- Organizer
  香川大学農学部第2回公開シンポジウム「生命を化学の視点から探究する」
- Place of Presentation
  香川大学農学部
- Year and Date
  2011-03-14
- Invited
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] アミロイドβ の毒性ターン構造を認識する抗体の開発2011
- Author(s)
  入江一浩
- Organizer
  第52回日本神経学会学術大会
- Place of Presentation
  名古屋
- Year and Date
  2011-05-19
- Invited
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] アミロイドβタンパクの毒性コンホメーションの同定と薬剤開発2010
- Author(s)
  入江一浩
- Organizer
  香川大学農学部第2回公開シンポジウム
- Place of Presentation
  香川大学農学部(木田郡)(招待講演)
- Year and Date
  2010-03-14
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] Structural analysis of toxic conformer of 42-mer amyloid β peptide using ESR spectrometry2010
- Author(s)
  Murakami, K. and Irie, K
- Organizer
  Asia-Pacific EPR/ESR symposium
- Place of Presentation
  Jeju, Republic of Korea
- Year and Date
  2010-10-12
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] Synthesis and biological profile of simple analogues of tumor-promoting aplysiatoxin as unique leads for anti-cancer drugs2010
- Author(s)
  Kazuhiro Irie
- Organizer
  2010 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010)
- Place of Presentation
  Hilton Hawaiian Village (Hawaii, USA)
- Year and Date
  2010-12-18
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] アミロイドβ の毒性コンホマーを標的とした立体構造特異的抗体2010
- Author(s)
  村上一馬, 堀越(櫻庭)優子, 村田央, 野田義博, 増田裕一, 木下憲明, 初田裕幸, 村山繁雄, 白澤卓二, 清水孝彦, 入江一浩
- Organizer
  2010年度日本農芸化学会大会
- Place of Presentation
  東京
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] アミロイドβ (Aβ42) の毒性コンホマー特異的抗体の作製2010
- Author(s)
  村上一馬, 堀越(櫻庭)優子, 村田央, 野田義博, 増田裕一, 木下憲明, 初田裕幸, 村山繁雄, 白澤卓二, 清水孝彦, 入江一浩
- Organizer
  第52回天然有機化合物討論会
- Place of Presentation
  静岡
- Year and Date
  2010-09-30
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] 固体NMR及びESRによるβアミロイドの立体構造と神経細胞毒性発現機構の解析2008
- Author(s)
  入江一浩
- Organizer
  理研シンポジウム「第9回分析・解析技術と化学の最先端」
- Place of Presentation
  埼玉
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-18208011
[Presentation] アルツハイマー病因ペプチドの毒性コンホメーション2008
- Author(s)
  入江一浩
- Organizer
  2008年度日本農芸化学会大会
- Place of Presentation
  名古屋
- Year and Date
  2008-03-29
- Data Source
  KAKENHI-PROJECT-18208011
[Presentation] βアミロイド心立体構造解析と神経細胞毒性発現機構2008
- Author(s)
  入江一浩
- Organizer
  第43回天然物化学談話会
- Place of Presentation
  大阪
- Year and Date
  2008-07-12
- Data Source
  KAKENHI-PROJECT-18208011
[Presentation] Verification of the intermolecular parallel beta-sheet in E22K-Abeta42 (Italian) aggregates by solid-state NMR using rotational resonance : implications for the supramolecular arrangement of the toxic conformer of Abeta422008
- Author(s)
  Kazuhiro Irie
- Organizer
  38th Annual Meeting of Society for Neuroscience
- Place of Presentation
  Washington D. C., USA
- Year and Date
  2008-11-16
- Data Source
  KAKENHI-PROJECT-18208011
[Presentation] アルッハイマ-病因ペプチドの毒性コンポメ-ション2008
- Author(s)
  入江一浩
- Organizer
  2008年度日本農芸化学会大会
- Place of Presentation
  名古屋
- Year and Date
  2008-03-29
- Data Source
  KAKENHI-PROJECT-18208011
[Presentation] Verification of the intermolecular parallel (β-sheet in E22K-Aβ42 (Italian) aggregates by solid-state NMR using rotational resonance2008
- Author(s)
  Kazuhiro Irie
- Organizer
  38th Annual Meeting of Society for Neuroscience
- Place of Presentation
  Washington D.C., USA
- Year and Date
  2008-11-16
- Data Source
  KAKENHI-PROJECT-18208011
[Presentation] アルツハイマー病因ペプチド(Aβ42)の毒性コンホメーション2008
- Author(s)
  入江一浩
- Organizer
  2008年度日本農芸化学会大会
- Place of Presentation
  名古屋
- Year and Date
  2008-03-29
- Data Source
  KAKENHI-PROJECT-18208011
[Presentation] βアミロイドの毒性コンホメーシヨンのESRならびに固体NMRによる検証2008
- Author(s)
  入江一浩
- Organizer
  第27回日本認知症学会集会
- Place of Presentation
  前橋
- Year and Date
  2008-10-10
- Data Source
  KAKENHI-PROJECT-18208011
[Presentation] アミロイドβ凝集体の立体構造解析と神経細胞毒性発現機構2008
- Author(s)
  入江一浩
- Organizer
  彩都バイオヒルズクラブプロテオミクスシンポジウム
- Place of Presentation
  大阪
- Year and Date
  2008-04-28
- Data Source
  KAKENHI-PROJECT-18208011
[Presentation] Verification of the intermolecular parallel β-sheet in E22K-Aβ42 (Italian) aggregates by solid-state NMR using rotational resonance2008
- Author(s)
  Kazuhiro Irie
- Organizer
  38th Annual Meeting of Society for Neuroscience
- Place of Presentation
  Washington D.C., USA
- Year and Date
  2008-11-16
- Data Source
  KAKENHI-PROJECT-18208011
[Presentation] 固体NMR及びESRによるβアミロイドの立体構造と神経細胞毒性発現機構の解析2008
- Author(s)
  入江一浩
- Organizer
  理研シンポジウム「第9回分析・解析技術と化学の最先端」
- Place of Presentation
  東京
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-18208011
[Presentation] アミロイドβタンパクの毒性コンホメーション2008
- Author(s)
  入江一浩
- Organizer
  第54回白鷺セミナー
- Place of Presentation
  大阪
- Year and Date
  2008-12-15
- Data Source
  KAKENHI-PROJECT-18208011
[Presentation] βアミロイドの立体構造解析と神経細胞毒性発現機構2008
- Author(s)
  入江一浩
- Organizer
  第43回天然物化学談話会
- Place of Presentation
  大阪
- Year and Date
  2008-07-12
- Data Source
  KAKENHI-PROJECT-18208011
[Presentation] 固体NMRならびにESRによるアミロイドβ (Aβ42) の毒性コンホメーションの解析2007
- Author(s)
  入江一浩
- Organizer
  第49回天然有機化合物討論会
- Place of Presentation
  札幌
- Year and Date
  2007-09-19
- Data Source
  KAKENHI-PROJECT-18208011
[Presentation] アルツハイマー病因ペプチド(Aβ42)の神経細胞毒性発現機構2007
- Author(s)
  入江一浩
- Organizer
  ハイテクリサーチセンター第2回シンポジウム
- Place of Presentation
  仙台
- Year and Date
  2007-05-25
- Data Source
  KAKENHI-PROJECT-18208011
[Presentation] 固体NMRならびにESRによるアミロイドβ(Aβ42)の毒性コンホメーションの解析2007
- Author(s)
  入江一浩
- Organizer
  第49回天然有機化合物討論会
- Place of Presentation
  札幌
- Year and Date
  2007-09-19
- Data Source
  KAKENHI-PROJECT-18208011
[Presentation] アルツハイマー病因ペプチド (Aβ42) の神経細胞毒性発現機構2007
- Author(s)
  入江一浩
- Organizer
  東北薬科大学ハイテクリサーチセンター第2回シンポジウム
- Place of Presentation
  仙台
- Year and Date
  2007-05-25
- Data Source
  KAKENHI-PROJECT-18208011
[Presentation] Toxic conformer of the 42-mer amyloid β (Aβ42)2007
- Author(s)
  Kazuhiro Irie
- Organizer
  37th Annual Meeting of Society for Neuroscience
- Place of Presentation
  San Diego, USA
- Year and Date
  2007-11-06
- Data Source
  KAKENHI-PROJECT-18208011
[Presentation] Malignant conformation of the 42-mer amyloid β peptide2006
- Author(s)
  Kazuhiro Irie
- Organizer
  2nd International Symposium on Biomolecules and Related Compounds
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2006-11-10
- Data Source
  KAKENHI-PROJECT-18208011
[Presentation] Synthesis and biological activities of the simplified analogs of a natural PKC ligand aplysiatoxin
- Author(s)
  Kazuhiro Irie
- Organizer
  International Symposium on Natural Products Chemistry and Chemical Biology 2013
- Place of Presentation
  Hotel Rubura Ohzan (Nagoya)
- Invited
- Data Source
  KAKENHI-PLANNED-23102011
[Presentation] 寄生植物由来化合物のアミロイドβ凝集阻害活性に関する研究
- Author(s)
  栗栖真奈美、宮前友策、木立恵利、村上一馬、Han Junkyu、礒田博子、入江一浩、繁森英幸
- Organizer
  新規素材探索研究会第11回セミナー
- Place of Presentation
  新横浜フジビューホテル、横浜
- Data Source
  KAKENHI-PROJECT-24580156
[Presentation] ポリフェノールによるアミロイド β の凝集抑制機構
- Author(s)
  入江　一浩
- Organizer
  2013年度日本農芸化学会大会シンポジウム
- Place of Presentation
  東北大学川内キャンパス（仙台市）
- Invited
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] 植物由来桂皮酸誘導体のアミロイドβ凝集阻害活性に関する研究
- Author(s)
  栗栖真奈美、宮前友策、木立恵利、村上一馬、Han Junkyu、礒田博子、入江一浩、繁森英幸
- Organizer
  第２回植物生理科学シンポジウム
- Place of Presentation
  北海道大学、札幌
- Data Source
  KAKENHI-PROJECT-24580156
[Presentation] ポリフェノールによるアミロイドβの凝集阻害機構
- Author(s)
  入江　一浩
- Organizer
  第31回日本認知症学会学術集会
- Place of Presentation
  つくば国際会議場（つくば市）
- Invited
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] Monoclonal antibody against a toxic conformer of Abeta42 with a turn at E22-D23
- Author(s)
  Kazuhiro Irie
- Organizer
  Alzheimer's Association International Conference (AAIC) 2012
- Place of Presentation
  Vancouver Convention Center (Canada)
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] アミロイド β タンパクの毒性ターン構造の同定とその構造特異抗体の開発
- Author(s)
  入江　一浩
- Organizer
  第15回アグリバイオセミナー
- Place of Presentation
  近畿大学農学部（奈良市）
- Invited
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] 日本産フサコケムシに含まれるブリオスタチン類の同定と活性評価
- Author(s)
  植野紗代、柳田亮、村上一馬、村上明、徳田春邦、鈴木信孝、藤原健史、入江一浩
- Organizer
  2012年度日本農芸化学会大会
- Place of Presentation
  京都女子大学（京都市）
- Data Source
  KAKENHI-PROJECT-23658100
[Presentation] 干しいもに含まれるカフェオイルキナ酸のアルツハイマー症予防効果
- Author(s)
  繁森英幸、宮前友策、栗栖真奈美、狢川喬、村上一馬、入江一浩、韓畯奎、礒田博子
- Organizer
  第23回日本化学会関東支部茨城地区研究交流会
- Place of Presentation
  日立シビックセンター、茨城
- Data Source
  KAKENHI-PROJECT-24580156

1. SHIMIZU Takahiko (40301791)

# of Collaborated Projects: 6 results

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2. MURAKAMI Kazuma (80571281)

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IRIE Kazuhiro 入江 一浩

Research Projects

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Development of inhibitors for the toxic oligomer formation based on the binding mode of amyloid beta and gangliosidePrincipal Investigator

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Development to ultra-early diagnosis and prevention of AD by using a specific antibody against the toxic conformation of amyloid betaPrincipal Investigator

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Very early diagnosis of Alzheimer's disease by the toxic oligomer specific antibody of amyloid betaPrincipal Investigator

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Unified comprehension of chemical communication by natural PKC ligands and development of new medicinal seedsPrincipal Investigator

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Novel Preventive Strategy for Alzheimer's Disease Based on the Toxic Conformation Theory of Amyloid betaPrincipal Investigator

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アミロイドβの毒性配座理論に基づいたアルツハイマー病の新規診断法の開発Principal Investigator

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Development and mechanistic analysis of new PKC ligands as anti-cancer agentsPrincipal Investigator

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Search for novel PKC ligands as therapeutic seeds for intractable diseasesPrincipal Investigator

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IRIE Kazuhiro 入江一浩