IRIE Kazuhiro 入江一浩

Researcher Number	00168535
Other IDs
Affiliation (Current)	2022: 京都大学, 農学研究科, 教授
Affiliation (based on the past Project Information) *help	2015 – 2021: 京都大学, 農学研究科, 教授 2016: 京都大学, (連合)農学研究科, 教授 2011 – 2016: 京都大学, (連合)農学研究科(研究院), 教授 2014: 京都大学, 大学院農学研究科, 教授 2012: 京都大学, 大学院・農学研究科, 教授 … More
Review Section/Research Field	Principal Investigator Bioproduction chemistry/Bioorganic chemistry / Science and Engineering / Bioproduction chemistry/Bioorganic chemistry / Living organism molecular science / Bioorganic chemistry / Chemical biology / Medium-sized Section 37:Biomolecular chemistry and related fields Except Principal Investigator Science and Engineering / Bioproduction chemistry/Bioorganic chemistry / Biological Sciences / Living organism molecular science / 製造化学・食品 / Bioorganic chemistry
Keywords	Principal Investigator プロテインキナーゼC / ホルボールエステル / 発がんプロモーター / インドラクタム / Aβ42 / 発癌プロモーター / 光アフィニティーラベリング / アルツハイマー病 / 凝集 / アルツハイマー … More Except Principal Investigator アルツハイマー病 / ケミカルバイオロジー / 天然物化学 / インドラクタム / Aβ42 / βアミロイド / 凝集 / 酸化ストレス / ラジカル / 電子スピン共鳴法 / ターン形成 / 天然物 / 標的同定 / 天然物リガンド / 国際交流（ドイツ） / 国際交流（米国） / 国際交流（韓国） / 国際交流（スウェーデン） / 異分野融合 / 国際研究者交流（米国） / 国際研究者交流（中国） / 国際研究者交流（韓国） / 天然物ケミカルバイオロジー / 分子設計 / アミロイドβ凝集阻害活性 / Th-T / カフェ酸誘導体 / HGF産生促進活性 / サツマイモ / コーヒー / 神経細胞保護作用 / Aβ凝集阻害活性 / アルツハイマー症 / キノコ / 地骨皮 / ビスフラボノイド / HGF / カフェオイルキナ酸 / フェニルエタノイド配糖体 / 記憶障害改善 / プロポリス / 生理活性 / 蛋白質 / 糖 / 有機合成 / タンパク質 / テレオシジン / 発癌プロモーター / 生合成 / 微生物転換 / 閉環酵素 / 発癌プロモ-タ- / (-)-Indolactam-V / Teleocidin / Tumor promoter / Biosynthesis / Cyclization enzyme / Microbial conversion / アプリシアトキシン / ジアシルグリセロールキナーゼ / C1 ドメイン / 発がんプロモーター / ブライオスタチン / プロテインキナーゼ C / ホルボールエステル / 亜鉛フィンガー / C1ドメイン / プロテインキナーゼC / GFP / RasGRP / chimaerin / Unc13 / indolactam-V / aplysiatoxin / bryostatin / C1 domain / diacylglycerol kinase / indolactam / phorbol ester / protein kinase C / tumor promoter / 抗酸化能 / プロオキシダント能 / 銅イオン還元能 / ヒドロキシルラジカル / スーパーオキシドディスムターゼ 1 / 蛋白質変性 / antioxidant / prooxidant / copper-induced oxidation / hydroxyl radical / superoxide dismutase / G6PDH / protein stability / 抗酸化 / プロオキシダント性 / 分子酸化 / 化学コミュニケーション / 分子社会学 / 生物活性リガンド Less

Very early diagnosis of Alzheimer's disease by the toxic oligomer specific antibody of amyloid betaPrincipal Investigator
- Principal Investigator
  
  入江一浩
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 37:Biomolecular chemistry and related fields
- Research Institution
  Kyoto University
Unified comprehension of chemical communication by natural PKC ligands and development of new medicinal seedsPrincipal Investigator
- Principal Investigator
  
  入江一浩
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  Kyoto University
Frontiers in Chemical Communications
- Principal Investigator
  
  掛谷秀昭
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  Kyoto University
Investigation on antioxidants with low pro-oxidant activity to stabilize proteins responsible for neurodegenerative disease.
- Principal Investigator
  
  KUROKAWA Yoichi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Fukui Prefectural University
Novel Preventive Strategy for Alzheimer's Disease Based on the Toxic Conformation Theory of Amyloid betaPrincipal Investigator
- Principal Investigator
  
  Irie Kazuhiro
- Project Period (FY)
  2014 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Kyoto University
アミロイドβの毒性配座理論に基づいたアルツハイマー病の新規診断法の開発Principal Investigator
- Principal Investigator
  
  入江一浩
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Chemical biology
- Research Institution
  Kyoto University
Search for Inhibitors of Amyloid beta Aggregation from Edible Plants and Their Mechanism
- Principal Investigator
  
  SHIGEMORI Hideyuki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  University of Tsukuba
A new strategy for designing mannose receptors based on enantiomers of protein domains.
- Principal Investigator
  
  NAKAGAWA Yu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Living organism molecular science
- Research Institution
  Nagoya University
  Institute of Physical and Chemical Research
Chemical biology using natural products
- Principal Investigator
  
  UEDA Minoru
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  Tohoku University
Development and mechanistic analysis of new PKC ligands as anti-cancer agentsPrincipal Investigator
- Principal Investigator
  
  IRIE Kazuhiro
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  Kyoto University
Search for novel PKC ligands as therapeutic seeds for intractable diseasesPrincipal Investigator
- Principal Investigator
  
  IRIE Kazuhiro
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Kyoto University
Development of medicinal seeds for Alzheimer's disease based on the structural analysis of toxic oligomers of amyloid betaPrincipal Investigator
- Principal Investigator
  
  IRIE Kazuhiro
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Kyoto University
インドール環4位への窒素原子導入酵素の触媒機構の解析と応用Principal Investigator
- Principal Investigator
  
  入江一浩
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Kyoto University
CH/π相互作用を利用したPKCアイソザイム選択的な薬剤開発Principal Investigator
- Principal Investigator
  
  入江一浩
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Kyoto University
Development of antibodies and aggregation inhibitors for amyloid β peptides based on the new aggregation modelPrincipal Investigator
- Principal Investigator
  
  IRIE Kazuhiro
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Kyoto University
アミロイドβ42凝集体のターン構造をエピトープとしたワクチン療法の開発
- Principal Investigator
  
  白澤卓二
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Metropolitan Institute of Gerontology
CH/π相互作用を利用したPKCδ選択的薬剤の創製Principal Investigator
- Principal Investigator
  
  入江一浩
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Kyoto University
Structural analysis of β-amyloid fibrils using solid-state NMRPrincipal Investigator
- Principal Investigator
  
  IRIE Kazuhiro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  KYOTO UNIVERSITY
質量分析法によるリガンド-レセプター相互作用の精密解析Principal Investigator
- Principal Investigator
  
  入江一浩
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Living organism molecular science
- Research Institution
  Kyoto University
Development of new agents that regulate cellular signal transduction
- Principal Investigator
  
  OHIGASHI Hajime
- Project Period (FY)
  2003 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  KYOTO UNIVERSITY
発がんプロモーションのメカニズム解明のための鍵化合物の開発と応用Principal Investigator
- Principal Investigator
  
  入江一浩
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Kyoto University
Elucidation of aggregation mechanism of Alzheimer's β-peptides and development of their aggregation inhibitorsPrincipal Investigator
- Principal Investigator
  
  IRIE Kazuhiro
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Kyoto University
発がんプロモーションのメカニズム解明のための鍵化合物の開発Principal Investigator
- Principal Investigator
  
  入江一浩
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Science and Engineering
- Research Institution
  Kyoto University
Synthesis and characterization of the regulatory domains of protein kinase CPrincipal Investigator
- Principal Investigator
  
  IRIE Kazuhiro
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  KYOTO UNIVERSITY
発癌プロモーターとプロテインキナーゼCとの結合様式の有機化学的解析Principal Investigator
- Principal Investigator
  
  入江一浩
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
Synthesis and PKC binding of conformationally restricted indolactams by aza-Claisen rearrangementPrincipal Investigator
- Principal Investigator
  
  IRIE Kazuhiro
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  KYOTO UNIVERSITY
発癌プロモーターとプロテインキナーゼCとの結合様式の有機化学的解析Principal Investigator
- Principal Investigator
  
  入江一浩
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
新規水溶性フラーレン誘導体の合成とフォトダイナミックアクションPrincipal Investigator
- Principal Investigator
  
  入江一浩
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Kyoto University
発癌プロモーターとプロテインキナーゼCとの結合様式の有機化学的解析Principal Investigator
- Principal Investigator
  
  入江一浩
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
立体配座を固定した発癌プロモーター・テレオシジン誘導体の合成と生物活性Principal Investigator
- Principal Investigator
  
  入江一浩
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Kyoto University
プロテインキナーゼCの光アフィニティーラベリングPrincipal Investigator
- Principal Investigator
  
  入江一浩
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Kyoto University
Character and Application of the Cyclization Enzyme at position 4 of an indole ring.
- Principal Investigator
  
  KOSHIMIZU Koichi
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  製造化学・食品
- Research Institution
  KYOTO UNIVERSITY

[Book] CSJ Current Review　生物活性分子のケミカルバイオロジー　標的同定と作用機構2015
- Author(s)
  入江一浩　他30名
- Publisher
  化学同人
- Data Source
  KAKENHI-PLANNED-23102011
[Book] 固体NMR およびESR によるアミロイド β の立体構造解析と毒性ターン構造特異抗体の開発, 遺伝子医学MOOK21 号「最新ペプチド合成技術とその創薬研究への応用」2012
- Author(s)
  村上一馬, 増田裕一, *入江一浩
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PROJECT-21248015
[Book] Identification of toxic conformation in Aβ42 aggregates using solid-state NMR2009
- Author(s)
  Y. Masuda, 他3名, K. Takegoshi, *K. Irie
- Publisher
  The Japanese Peptide Society
- Data Source
  KAKENHI-PROJECT-18208011
[Book] 'Malignant' conformation of Alzheimer's β peptide (Aβ42) through radical formation (H. Ishida and H. Mihara (Eds.))2006
- Author(s)
  K. Murakami, *K. Irie, 他3名, T. Shimizu, T. Shirasawa
- Publisher
  The Japanese Peptide Society
- Data Source
  KAKENHI-PROJECT-18208011
[Journal Article] Synthesis of Alkyl Bridged‐Tris‐α‐Amino Acids as C3‐Symmetric and Linear Linkers2021
- Author(s)
  Uchino Ayumi、Tsukano Chihiro、Imamoto Tsuneo、Irie Kazuhiro
- Journal Title
  
  European Journal of Organic Chemistry
  
  Volume: 2021 Pages: 1370-1377
- DOI
  10.1002/ejoc.202001592
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H00921
[Journal Article] Development of a Novel Alzheimer's Disease Model Based on the Theory of the Toxic-conformer of Amyloid β2021
- Author(s)
  泉尾直孝、清水孝彦、村上一馬、入江一浩
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 141 Issue: 6 Pages: 843-849
- DOI
  10.1248/yakushi.20-00251-5
- NAID
  130008046322
- ISSN
  0031-6903, 1347-5231
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-26221202
[Journal Article] Searching for natural products that delay nucleation phase and promote elongation phase of amyloid beta42 toward Alzheimer's disease therapeutics2021
- Author(s)
  Murakami Kazuma, Horii Shiori, Hanaki Mizuho, Irie Kazuhiro
- Journal Title
  
  ACS Chemical Neuroscience
  
  Volume: 12 Pages: 3467-3476
- DOI
  10.1021/acschemneuro.1c00489
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26221202
[Journal Article] Toxic Amyloid-β42 Conformer May Accelerate the Onset of Alzheimer's Disease in the Preclinical Stage.2021
- Author(s)
  Futamura Akinori、Hieda Sotaro、Mori Yukiko、Kasuga Kensaku、Sugimoto Azusa、Kasai Hideyo、Kuroda Takeshi、Yano Satoshi、Tsuji Mayumi、Ikeuchi Takeshi、Irie Kazuhiro、Ono Kenjiro
- Journal Title
  
  J Alzheimers Dis
  
  Volume: 80 Pages: 639-646
- DOI
  10.3233/jad-201407
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07965, KAKENHI-PROJECT-20K11266, KAKENHI-PROJECT-20K19111, KAKENHI-PROJECT-19H00921
[Journal Article] アミロイドタンパク質を認識する核酸アプタマー2021
- Author(s)
  村上一馬、入江一浩
- Journal Title
  
  化学と生物
  
  Volume: 59 Pages: 216-218
- Data Source
  KAKENHI-PROJECT-26221202
[Journal Article] Effects of side chain length of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, on PKC binding, anti-proliferative, and pro-inflammatory activities2021
- Author(s)
  Atsuko Gonda, Koji Takada, Ryo C. Yanagita, Shingo Dan, and Kazuhiro Irie*
- Journal Title
  
  Bioscience, Biotechnology and Biochemistry
  
  Volume: 85 Issue: 1 Pages: 168-180
- DOI
  10.1093/bbb/zbaa024
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-17H06405, KAKENHI-PROJECT-16H06276
[Journal Article] New diagnostic method for Alzheimer's disease based on the toxic conformation theory of amyloid β2020
- Author(s)
  Irie Kazuhiro
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 84 Pages: 1-16
- DOI
  10.1080/09168451.2019.1667222
- NAID
  120006800709
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-17H06405, KAKENHI-PROJECT-19H00921, KAKENHI-PROJECT-26221202
[Journal Article] Synthesis and biological activities of simplified aplysiatoxin analogs focused on the CH/pi interaction.2020
- Author(s)
  Takumi Kobayashi, Ryo, C. Yanagita, Kazuhiro Irie
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 30 Pages: 127657-127657
- DOI
  10.1016/j.bmcl.2020.127657
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-17H06405, KAKENHI-PROJECT-16H06276
[Journal Article] Control of the toxic conformation of amyloid β42 by intramolecular disulfide bond formation2020
- Author(s)
  Matsushima Yuka、Yanagita Ryo C.、Irie Kazuhiro
- Journal Title
  
  Chemical Communications
  
  Volume: 56 Pages: 4118-4121
- DOI
  10.1039/d0cc01053g
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H00921
[Journal Article] An RNA aptamer with potent affinity for a toxic dimer of amyloid β42 has potential utility for histochemical studies of Alzheimer’s disease2020
- Author(s)
  Murakami Kazuma, Obata Yayoi, Sekikawa Asa, Ueda Haruka, Awano Tatsuya, Takabe Keiji, Takahiko Shimizu, Irie Kazuhiro
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 295 Pages: 4870-4880
- DOI
  10.1074/jbc.ra119.010955
- Description
  in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26221202, KAKENHI-PROJECT-16H06194, KAKENHI-PROJECT-20H03583
[Journal Article] Detection of amyloid beta oligomers with RNA aptamers in APP^<NL-G-F/NL-G-F> mice : a model of arctic Alzheimer's disease2020
- Author(s)
  Obata Yayoi, Murakami Kazuma, Kawase Taiji, Hirose Kenji, Izuo Naotaka, Shimizu Takahiko, Irie Kazuhiro
- Journal Title
  
  ACS Omega
  
  Volume: 5 Pages: 21531-21537
- DOI
  10.1021/acsomega.0c02134
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06194, KAKENHI-PROJECT-20H03583, KAKENHI-PROJECT-26221202
[Journal Article] Synthetic and biochemical studies on the effect of persulfidation on disulfide dimer models of amyloid β42 at position 35 in Alzheimer's etiology2020
- Author(s)
  Murakami Kazuma, Kato Haruka, Hanaki Mizuho, Monobe Yoko, Akagi Ken-ichi, Kawase Taiji, Hirose Kenji, Irie Kazuhiro
- Journal Title
  
  RSC Advances
  
  Volume: 10 Pages: 19506-19512
- DOI
  10.1039/d0ra03429k
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26221202, KAKENHI-PROJECT-16H06194
[Journal Article] Evaluation of Toxic Amyloid β42 Oligomers in Rat Primary Cerebral Cortex Cells and Human iPS-derived Neurons Treated with 10-Me-Aplog-1, a New PKC Activator2020
- Author(s)
  Murakami Kazuma、Yoshimura Mayuko、Nakagawa Shota、Kume Toshiaki、Kondo Takayuki、Inoue Haruhisa、Irie Kazuhiro
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Pages: 1179-1179
- DOI
  10.3390/ijms21041179
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07119, KAKENHI-PLANNED-17H06405, KAKENHI-PROJECT-17K16121
[Journal Article] Three Structural Features of Functional Food Components and Herbal Medicine with Amyloid β42 Anti-Aggregation Properties2019
- Author(s)
  Murakami Kazuma, Irie Kazuhiro
- Journal Title
  
  Molecules
  
  Volume: 24 Pages: 2125-2125
- DOI
  10.3390/molecules24112125
- NAID
  120006644072
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26221202, KAKENHI-PROJECT-16H06194
[Journal Article] An App knock-in mouse inducing the formation of a toxic conformer of Aβ as a model for evaluating only oligomer-induced cognitive decline in Alzheimer's disease2019
- Author(s)
  Izuo Naotaka, Murakami Kazuma, Fujihara Yoshitaka, Maeda Masahiro, Saito Takashi, Saido C. Takaomi, Irie Kazuhiro, Shimizu Takahiko
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 515 Pages: 462-467
- DOI
  10.1016/j.bbrc.2019.05.131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26221202
[Journal Article] Crystal structure analysis of the antibody that is specific to the toxic conformer of amyloid beta2019
- Author(s)
  Irie Kazuhiro、Irie Yumi、Kita Akiko
- Journal Title
  
  Photon Factory Activity Report 2018
  
  Volume: 36
- Data Source
  KAKENHI-PROJECT-19H00921
[Journal Article] Synthesis, conformation, and biological activities of a des-A-ring analog of 18-deoxy-aplog-l, a simplified analog of debromoaplysiatoxin2019
- Author(s)
  Ashida, Y., Yanagita, R. C., Kawanami, Y., Okamura, M., Dan, S. and Irie, K.
- Journal Title
  
  Heterocycles
  
  Volume: 99
- DOI
  10.3987/com-18-s(f)60
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-17H06405, KAKENHI-PROJECT-16H06276
[Journal Article] Synthesis and biochemical characterization of quasi-stable trimer models of full-length amyloid β40 with a toxic conformation2019
- Author(s)
  Irie Yumi、Hanaki Mizuho、Murakami Kazuma、Imamoto Tsuneo、Furuta Takumi、Kawabata Takeo、Kawase Taiji、Hirose Kenji、Monobe Yoko、Akagi Ken-ichi、Yanagita Ryo C.、Irie Kazuhiro
- Journal Title
  
  Chemical Communications
  
  Volume: 55 Pages: 182-185
- DOI
  10.1039/c8cc08618d
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26221202, KAKENHI-PROJECT-18H02554
[Journal Article] Synthesis and Structure-Function Analyses of the Toxic Dimer and Trimer Models of Amyloid β2019
- Author(s)
  Irie Kazuhiro
- Journal Title
  
  J. Syn. Org. Chem., Jpn.
  
  Volume: 77 Issue: 12 Pages: 1201-1208
- DOI
  10.5059/yukigoseikyokaishi.77.1201
- NAID
  130007760861
- ISSN
  0037-9980, 1883-6526
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H00921, KAKENHI-PROJECT-26221202
[Journal Article] Amyloid β toxic conformer has dynamic localization in the human inferior parietal cortex in absence of amyloid plaques2018
- Author(s)
  Kageyama Yusuke、Saito Atsushi、Pletnikova Olga、Rudow Gay L.、Irie Yumi、An Yang、Murakami Kazuma、Irie Kazuhiro、Resnick Susan M.、Fowler David R.、Martin Lee J.、Troncoso Juan C.
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Pages: 16895-16895
- DOI
  10.1038/s41598-018-35004-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221202
[Journal Article] Change of amyloid-β 1-42 toxic conformer ratio after cerebrospinal fluid diversion predicts long-term cognitive outcome in patients with idiopathic normal pressure hydrocephalus.2018
- Author(s)
  Akiba C, Nakajima M, Miyajima M, Ogino I, Motoi Y, Kawamura K, Adachi S, Kondo A, Sugano H, Tokuda T, Irie K, Arai H
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 25 Pages: 989-1002
- DOI
  10.3233/jad-180059
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10372, KAKENHI-PROJECT-17K10908, KAKENHI-PROJECT-26221202, KAKENHI-PROJECT-18H02916
[Journal Article] Synthesis and biological activities of acetal analogs at position 3 of 10-methyl-aplog-l, a potential anti-cancer lead derived from debromoaplysiatoxin2018
- Author(s)
  Hayakawa, K., Hanaki, Y., Tokuda, H., Yanagita, R. C., Nakagawa, Y., Okamura, M., Dan, S. and Irie, K.
- Journal Title
  
  Heterocycles
  
  Volume: 97 Issue: 1 Pages: 478-492
- DOI
  10.3987/com-18-s(t)37
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-17H06405, KAKENHI-PROJECT-16H05105, KAKENHI-PROJECT-16H06276
[Journal Article] Identification of Protein Kinase C Isozymes Involved in the Anti-Proliferative and Pro-Apoptotic Activities of 10-Methyl-aplog-1, a Simplified Analog of Debromoaplysiatoxin, in Several Cancer Cell Lines.2018
- Author(s)
  Yusuke Hanaki, Yuki Shikata, Masayuki Kikumori, Natsuki Hotta, Masaya Imoto, Kazuhiro Irie
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 495 Pages: 438-445
- DOI
  10.1016/j.bbrc.2017.11.052
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-17H06405, KAKENHI-PROJECT-15H03116, KAKENHI-PROJECT-16J04817, KAKENHI-PROJECT-18H02099
[Journal Article] アミロイドβ「毒性コンホマー」を標的にしたアルツハイマー病の治療・診断法の開発2018
- Author(s)
  泉尾直孝、清水孝彦、村上一馬、入江一浩
- Journal Title
  
  医薬品医療機器レギュラトリーサイエンス
  
  Volume: 49 Pages: 312-318
- Data Source
  KAKENHI-PROJECT-26221202
[Journal Article] Role of the carboxy groups of triterpenoids in their inhibition of the nucleation of amyloid β42 required for forming toxic oligomers2018
- Author(s)
  Murakami Kazuma、Yoshioka Takuya、Horii Shiori、Hanaki Mizuho、Midorikawa Satohiro、Taniwaki Shinji、Gunji Hiroki、Akagi Ken-ichi、Kawase Taiji、Hirose Kenji、Irie Kazuhiro
- Journal Title
  
  Chemical Communications
  
  Volume: 54 Pages: 6272-6275
- DOI
  10.1039/c8cc03230k
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26221202, KAKENHI-PROJECT-16H06194
[Journal Article] Mechanistic analyses of the suppression of amyloid β42 aggregation by apomorphine2018
- Author(s)
  Mizuho Hanaki, Kazuma Murakami, Sumie Katayama, Ken-ichi Akagi, Kazuhiro Irie
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 26 Pages: 1538-1546
- DOI
  10.1016/j.bmc.2018.01.028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26221202
[Journal Article] 食品・生薬成分によるアミロイドβ42の凝集抑制機構の系統的解析2017
- Author(s)
  村上一馬、入江一浩
- Journal Title
  
  日本認知症学会誌
  
  Volume: 31 Pages: 351-360
- Data Source
  KAKENHI-PROJECT-26221202
[Journal Article] A Toxic Conformer of Aβ42 with a Turn at 22?23 is a Novel Therapeutic Target for Alzheimer’s Disease2017
- Author(s)
  Naotaka Izuo, Chihiro Kasahara, Kazuma Murakami, Toshiaki Kume, Masahiro Maeda, Kazuhiro Irie, Koutaro Yokote, Takahiko Shimizu
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Pages: 11811-11811
- DOI
  10.1038/s41598-017-11671-6
- NAID
  120006368174
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26221202, KAKENHI-PROJECT-17H01558, KAKENHI-PROJECT-15K07965, KAKENHI-PROJECT-16J05570, KAKENHI-PROJECT-15K19279
[Journal Article] Synthetic models of quasi-stable amyloid β40 oligomers with significant neurotoxicity2017
- Author(s)
  Yumi Irie, Kazuma Murakami, Mizuho Hanaki, Yusuke Hanaki, Takashi Suzuki, Yoko Monobe, Tomoyo Takai, Ken-ichi Akagi, Taiji Kawase, Kenji Hirose, Kazuhiro Irie
- Journal Title
  
  ACS Chem. Neurosci.
  
  Volume: 8
- DOI
  10.1021/acschemneuro.6b00390
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26221202
[Journal Article] Semisynthesis and structure-activity studies of Uncarinic acid C Isolated from Uncaria rhynchophylla as a specific inhibitor of the nucleation phase in amyloid β42 aggregation2016
- Author(s)
  Takuya Yoshioka, Kazuma Murakami, Kyohei Ido, Mizuho Hanaki, Kanoko Yamaguchi, Satohiro Midorikawa, Shinji Taniwaki, Hiroki Gunji, Kazuhiro Irie
- Journal Title
  
  J. Nat. Prod.
  
  Volume: 79 Pages: 2521-2529
- DOI
  10.1021/acs.jnatprod.6b00392
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26221202
[Journal Article] Binding mode prediction of aplysiatoxin, a potent agonist of protein kinase C, through moleculer simulation and structure-activity study on simplified analogs of the receptor-recognition domain2016
- Author(s)
  Y Ashida, R. C. Yanagita*, C Takahashi, Y Kawanami, K Irie
- Journal Title
  
  Bioorg. Med. Chem
  
  Volume: 24 Pages: 4218-4227
- DOI
  10.1016/j.bmc.2016.07.011
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23102011
[Journal Article] アルツハイマー病の正確な早期診断の実現に向けて2016
- Author(s)
  入江一浩
- Journal Title
  
  化学
  
  Volume: 71 (11) Pages: 41-44
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26221202
[Journal Article] Monoclonal antibody with conformational specificity for a toxic conformer of amyloid b42 and its application toward the Alzheimer's disease diagnosis.2016
- Author(s)
  Kazuma Murakami, Maki Tokuda, Takashi Suzuki, Yumi Irie, Mizuho Hanaki, Naotaka Izuo, Yoko Monobe, Ken-ichi Akagi, Ryotaro Ishii, Harutsugu Tatebe, Takahiko Tokuda, Masahiro Maeda, Toshiaki Kume, Takahiko Shimizu, Kazuhiro Irie
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Pages: 29038-29038
- DOI
  10.1038/srep29038
- NAID
  120005774689
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221202, KAKENHI-PROJECT-26293165, KAKENHI-PROJECT-26462283, KAKENHI-PROJECT-16K14254, KAKENHI-PROJECT-15K07965, KAKENHI-PROJECT-15K09322, KAKENHI-PROJECT-15K19279, KAKENHI-PROJECT-16J05570
[Journal Article] Structural insights into mechanisms for inhibiting amyloid β42 aggregation by non-catechol-type flavonoids2016
- Author(s)
  Mizuho Hanaki, Kazuma Murakami, Ken-ichi Akagi, Kazuhiro Irie*
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 24 Pages: 304-313
- DOI
  10.1016/j.bmc.2015.12.021
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26221202
[Journal Article] Structural optimization of 10-methyl-aplog-1, a simplified 1 analog of 2 debromoaplysiatoxin, as an anticancer lead.2016
- Author(s)
  M. Kikumori, R. C. Yanagita, H. Tokuda, K. Suenaga, H. Nagai, and *K. Irie
- Journal Title
  
  Biosci. Biotech. Biochem.
  
  Volume: 80 Pages: 221-231
- DOI
  10.1080/09168451.2015.1091718
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-23102011, KAKENHI-PROJECT-16K01911
[Journal Article] ynthesis and biological activities of the amide derivative of aplog-1, a simplified analog of aplysiatoxin with anti-proliferative and cytotoxic activities2015
- Author(s)
  Yusuke Hanaki, Ryo C. Yanagita, Takahiro Sugahara, Misako Aida, Harukuni Tokuda, Nobutaka Suzuki, Kazuhiro Irie
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 印刷中 Pages: 888-895
- DOI
  10.1080/09168451.2014.1002452
- NAID
  120005676639
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-23102011, KAKENHI-PUBLICLY-26102733
[Journal Article] Synthesis and characterization of the amyloid β40 dimer model with a linker at position 30 adjacent to the intermolecular β-sheet region2015
- Author(s)
  Kazuma Murakami, Takashi Suzuki, Mizuho Hanaki, Yoko Monobe, Ken-ichi Akagi, Kazuhiro Irie*
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 466 Pages: 463-467
- DOI
  10.1016/j.bbrc.2015.09.051
- NAID
  120005679859
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26221202
[Journal Article] アルツハイマー病様神経毒性におけるアミロイドβコンホマーの役割2015
- Author(s)
  泉尾直孝*、村上一馬、久米利明、前田雅弘、入江一浩、清水孝彦
- Journal Title
  
  基礎老化研究
  
  Volume: 39 Pages: 29-34
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26221202
[Journal Article] Improved and large-scale synthesis of 10-methyl-aplog-1, a potential lead for an anticancer drug2014
- Author(s)
  Masayuki Kikumori, Ryo C. Yanagita, and Kazuhiro Irie
- Journal Title
  
  Tetrahedron
  
  Volume: 70 Pages: 9776-9782
- DOI
  10.1016/j.tet.2014.11.026
- NAID
  120005522771
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-13J02518, KAKENHI-PLANNED-23102011
[Journal Article] Synthesis and biological activities of simplified analogs of the natural PKC ligands, bryostatin-1 and aplysiatoxin2014
- Author(s)
  Kazuhiro Irie, Ryo C. Yanagita
- Journal Title
  
  Chem. Rec.
  
  Volume: 14 Pages: 251-267
- DOI
  10.1002/tcr.201300036
- NAID
  120005651918
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-23102011
[Journal Article] Structure–Activity Relationship for (+)-Taxifolin Isolated from Silymarin as an Inhibitor of Amyloid β Aggregation2013
- Author(s)
  Sato, M., Murakami, K., (他5名), Irie, K
- Journal Title
  
  Biosci. Biotechnol. Biochem.
  
  Volume: 77 Issue: 5 Pages: 1100-1103
- DOI
  10.1271/bbb.120925
- NAID
  10031177604
- ISSN
  0916-8451, 1347-6947
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248015
[Journal Article] Structure-activity studies at position 27 of aplog-1, a simplified analog of debromoaplysiatoxin with anti-proliferative activity2013
- Author(s)
  Yusuke Hanaki, Masayuki Kikumori, Sayo Ueno, Harukuni Tokuda, Nobutaka Suzuki and Kazuhiro Irie
- Journal Title
  
  Tetrahedron
  
  Volume: 69 Pages: 7636-7645
- DOI
  10.1016/j.tet.2013.02.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J02518, KAKENHI-PLANNED-23102011
[Journal Article] Site-specific inhibitory mechanism for amyloid β42 aggregation by catechol-type flavonoids targeting the Lys residues.2013
- Author(s)
  Sato, M., Murakami, K., Ikubo, H., Uno, M., Nakagawa, Y., Katayama, S., Akagi, K.-i., Masuda, Y., Takegoshi, K., *Irie, K
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 288 Pages: 23212-23224
- DOI
  10.1074/jbc.m113.464222
- NAID
  120005477416
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248015, KAKENHI-PROJECT-24780108
[Journal Article] Effects of the methoxy group in the side chain of debromoaplysiatoxin on its tumor-promoting and anti-proliferative activities2013
- Author(s)
  Ryo C. Yanagita, Hiroaki Kamachi, Masayuki Kikumori, Harukuni Tokuda, Nobutaka Suzuki, Kiyotake Suenaga, Hiroshi Nagai and Kazuhiro Irie
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 23 Pages: 4319-4323
- DOI
  10.1016/j.bmcl.2013.05.096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J02518, KAKENHI-PLANNED-23102011
[Journal Article] Intracellular accumulation of toxic turn amyloid-β is associated with endoplasmic reticulum stress in Alzheimer's disease2013
- Author(s)
  Soejima, N., Ohyagi, Y., (他6名), Murakami, K., Irie, K., (他5名)
- Journal Title
  
  Curr. Alzheimer Res
  
  Volume: 10 Pages: 11-20
- URL
  http://www.eurekaselect.com/106388/article
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248015
[Journal Article] Modeling Alzheimer's Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness.2013
- Author(s)
  Kondo, T., (他24名), Murakami, K., Irie, K., Klein, W. L., Mori, H., Asada, T., Takahashi, R., Iwata, N., Yamanaka, S., Inoue, H
- Journal Title
  
  Cell Stem Cell.
  
  Volume: 12 Pages: 780-4
- DOI
  10.1016/j.stem.2013.01.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21248015, KAKENHI-PLANNED-22129006, KAKENHI-ORGANIZER-23111001, KAKENHI-PLANNED-23111002, KAKENHI-PROJECT-23249049, KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-23592093, KAKENHI-PROJECT-24220009, KAKENHI-PROJECT-24500408, KAKENHI-PROJECT-24590040, KAKENHI-PROJECT-24700367, KAKENHI-PROJECT-24790260, KAKENHI-PROJECT-24790276, KAKENHI-PUBLICLY-25123709, KAKENHI-PROJECT-25290018, KAKENHI-PROJECT-25460341, KAKENHI-PUBLICLY-23110535, KAKENHI-PUBLICLY-23123510
[Journal Article] Structure-activity studies on the side chain of a simplified analog of aplysiatoxin (aplog-1) with anti-proliferative activit2013
- Author(s)
  Kamachi, H., Tanaka, K., Yanagita, R. C., Murakami, A., Murakami, K., Tokuda, H., Suzuki, N., Nakagawa, Y., Irie, K.
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 21 Pages: 2695-2702
- DOI
  10.1016/j.bmc.2013.03.013
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23102011
[Journal Article] Non-toxic conformer of Aβ42 may suppress Aβ42-induced toxicity in rat primary neurons: implications for the novel therapeutic strategy of Alzheimer’s disease2013
- Author(s)
  Izuo, N., Murakami, K., (他3名), Shimizu, T., Akaike, A., Irie, K., Kume, T
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 438 Pages: 1-5
- DOI
  10.1016/j.bbrc.2013.05.106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248015, KAKENHI-PROJECT-24390139, KAKENHI-PROJECT-24590111, KAKENHI-PROJECT-25460095, KAKENHI-PROJECT-25670036
[Journal Article] Inhibition of Amyloid β Aggregation by Acteoside, a Phenylethanoid Glycoside2013
- Author(s)
  M. Kurisu, Y. Miyamae, K. Murakami, J. Han, H. Isoda, K. Irie, and H. Shigemori
- Journal Title
  
  Biosci. Biotechnol. Biochem.
  
  Volume: 77 Issue: 6 Pages: 1329-1332
- DOI
  10.1271/bbb.130101
- NAID
  10031184707
- ISSN
  0916-8451, 1347-6947
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24580156
[Journal Article] Structure#8211;activity studies on the spiroketal moiety of a simplified analog of debromoaplysiatoxin with antiproliferative activity2012
- Author(s)
  M. Kikumori, R. C. Yanagita, H. Tokuda, N. Suzuki, H. Nagai, K. Suenaga, K. Irie
- Journal Title
  
  J. Med. Chem.
  
  Volume: 55 Pages: 5614-5626
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-23102001
[Journal Article] Stimulation of the Amyloidogenic Pathway by Cytoplasmic Superoxide Radicals in an Alzheimer's Disease Mouse Model2012
- Author(s)
  Murakami, K., Murata, N., Noda, Y., Irie, K., Shirasawa, T., Shimizu, T
- Journal Title
  
  Biosci. Biotechnol. Biochem.
  
  Volume: 76 Issue: 6 Pages: 1098-1103
- DOI
  10.1271/bbb.110934
- NAID
  10030817824
- ISSN
  0916-8451, 1347-6947
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248015, KAKENHI-PROJECT-22603006
[Journal Article] Identification and Biological Activities of Bryostatins from Japanese Bryozoan2012
- Author(s)
  Sayo Ueno
- Journal Title
  
  Biosci. Biotechnol. Biochem.
  
  Volume: 76 Issue: 5 Pages: 1041-1043
- DOI
  10.1271/bbb.120026
- NAID
  10030753324
- ISSN
  0916-8451, 1347-6947
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23658100
[Journal Article] Early accumulation of intracellular fibrillar oligomers and late congophilic amyloid angiopathy in mice expressing the Osaka intra-Aβ APP mutation2012
- Author(s)
  Kulic, L., (他10名), Shimizu, T., Murakami, K., Irie, K., (他4名)
- Journal Title
  
  Transl. Psychiatry
  
  Volume: 2
- DOI
  10.1038/tp.2012.109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248015
[Journal Article] Development of new anticancer drugs based on the activation mechanism of protein kinase C2012
- Author(s)
  Kazuhiro Irie, 他2名
- Journal Title
  
  Med. Res. Rev.
  
  Volume: (印刷中) Pages: 518-535
- DOI
  10.1002/med.20220
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23102011
[Journal Article] Protective effects of caffeoylquinic acids on the aggregation and neurotoxicity of the 42-residue amyloid β-protein2012
- Author(s)
  Y. Miyamae, M. Kurisu, K. Murakami, J. Han, H. Isoda, K. Irie, and H. Shigemori
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 20 Pages: 5844-5849
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24580156
[Journal Article] Toxicity in rat primary neuron through the cellular oxidative stress induced by the turn formation at positions 22 and 23 of Aβ422012
- Author(s)
  Naotaka Izuo
- Journal Title
  
  ACS Chem Neurosci
  
  Volume: 3(9) Pages: 647-681
- DOI
  10.1021/cn300033k
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J04068, KAKENHI-PROJECT-21248015, KAKENHI-PROJECT-23790083, KAKENHI-PROJECT-24390139, KAKENHI-PROJECT-24590111
[Journal Article] Synthesis and structure–activity studies of simplified analogues of aplysiatoxin with anti-proliferative activity like bryostatin-12012
- Author(s)
  Kazuhiro Irie, 他9名
- Journal Title
  
  Pure Appl. Chem.
  
  Volume: (印刷中) Pages: 1341-1351
- DOI
  10.1351/pac-con-11-08-22
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23102011, KAKENHI-PROJECT-24510294
[Journal Article] SOD1 (Copper/Zinc Superoxide Dismutase) deficiency drives amyloid β protein oligomerization and memory loss in mouse model of Alzheimer's disease.2011
- Author(s)
  Murakami, K., (他8名), Irie, K., Shirasawa, T., Shimizu, T
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 286 Pages: 44557-44568
- DOI
  10.1074/jbc.m111.279208
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248015, KAKENHI-PROJECT-22300118, KAKENHI-PROJECT-22603006
[Journal Article] Analysis of interaction sites of curcumin with the fibrils of 42-residue amyloid β-protein (Aβ42) using solid-state NMR2011
- Author(s)
  Masuda, Y., Fukuchi, M., Yatagawa, T., Tada, M., Takeda, K., Irie, K., Akagi, K., Monobe, Y., Imazawa, T., Takegoshi, K.
- Journal Title
  
  Biosci.Biotechnol.Biochem.
  
  Volume: 19 Pages: 1167-1173
- DOI
  10.1016/j.bmc.2011.08.052
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-09J01128, KAKENHI-PROJECT-21248015, KAKENHI-PLANNED-23102011
[Journal Article] Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 232010
- Author(s)
  Murakami, K., (他8名), Shimizu, T., Irie, K
- Journal Title
  
  ACS Chem. Neurosci
  
  Volume: 1 Pages: 747-756
- DOI
  10.1021/cn100072e
- NAID
  130004504903
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248015
[Journal Article] E22Δ mutation in amyloid β-protein promotes β-sheet transformation, radical production, and synaptotoxicity, but not neurotoxicity2010
- Author(s)
  Suzuki, T., Murakami, K., (他7名), Irie, K
- Journal Title
  
  Int. J. Alzheimers Dis
  
  Volume: 431320
- DOI
  10.4061/2011/431320
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248015
[Journal Article] The turn formation at positions 22 and 23 in the 42-mer amyloid beta peptide : the emerging role in the pathogenesis of Alzheimer's disease2010
- Author(s)
  Murakami, K., Masuda, Y., Shirasawa, T., Shimizu, T., Irie, K
- Journal Title
  
  Geriatr. Gerontol. Int
  
  Volume: 10
- DOI
  10.1111/j.1447-0594.2010.00598.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248015
[Journal Article] Silymarin Attenuated the Amyloid .BETA. Plaque Burden and Improved Behavioral Abnormalities in an Alzheimer's Disease Mouse Model2010
- Author(s)
  Murata, N., Murakami, K., Ozawa, Y., Kinoshita, N., Irie, K., Shirasawa, T., Shimizu T
- Journal Title
  
  Biosci. Biotechnol. Biochem.
  
  Volume: 74 Issue: 11 Pages: 2299-2306
- DOI
  10.1271/bbb.100524
- NAID
  10027561730
- ISSN
  0916-8451, 1347-6947
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248015
[Journal Article] Identification of Physiological and Toxic Conformations in Aβ42 Aggregates2009
- Author(s)
  Y. Masuda,(他3名) K. Takegoshi, T. Shimizu, T. Shirasawa, K. Irie
- Journal Title
  
  ChemBioChem 10
  
  Pages: 287-295
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208011
[Journal Article] Identification of physiological and toxic conformations in Aβ42 aggregates2009
- Author(s)
  Y. Masuda, 他3名, 2-4番目, K. Takegoshi, T. Shimizu, T. Shirasawa, *K. Irie
- Journal Title
  
  ChemBioChem 10
  
  Pages: 287-295
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208011
[Journal Article] Isomerization and/or racemization at Asp23 of Aβ42 do not increase its aggregative ability, neurotoxicity, and radical productivity in vitro2008
- Author(s)
  K. Murakami, M. Uno, Y. Masuda, T. Shimizu, T. Shirasawa, *K. Irie,
- Journal Title
  
  Biochem. Biophys. Res. Commun. 366
  
  Pages: 745-751
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208011
[Journal Article] βアミロイドの毒性コンホメーション2008
- Author(s)
  *入江一浩, 増田裕一
- Journal Title
  
  化学と生物 46
  
  Pages: 431-434
- NAID
  10024333845
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208011
[Journal Article] Verification of the C-terminal intramolecular β-sheet in Aβ42 aggregates using solid-state NMR2008
- Author(s)
  Y. Masuda, 他3名, 2-4番目, K. Takegoshi, T. Shimizu, T. Shirasawa, *K. Irie
- Journal Title
  
  Bioorg. Med. Chem. Lett. 18
  
  Pages: 3206-3210
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208011
[Journal Article] βアミロイドの毒性コンホメーシヨン2008
- Author(s)
  入江一浩
- Journal Title
  
  化学と生物 46
  
  Pages: 431-434
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208011
[Journal Article] Verification of the Intermolecular Parallel 13-sheet in E22K-Aβ42 Aggregates by Solid-state NMR Using Rotational Resonance : Implications for the Supramolecular Arrangement of the Toxic Conformer of Aβ42. Biosci.2008
- Author(s)
  Y. Masuda,(他3名),K. Takegoshi, T. Shimizu, T. Shirasawa, K. Irie
- Journal Title
  
  Biotechnol. Biochem 72
  
  Pages: 2170-2175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208011
[Journal Article] βアミロイドの毒性コンポメ-ション2008
- Author(s)
  入江一浩, 増田裕一
- Journal Title
  
  化学と生物 46
  
  Pages: 431-434
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208011
[Journal Article] アミロイドβ (Aβ42) の毒性コンホメーションの提唱2008
- Author(s)
  *村上一馬, 清水孝彦, 白澤卓二, 入江一浩
- Journal Title
  
  基礎老化研究 32
  
  Pages: 25-29
- NAID
  10024377833
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208011
[Journal Article] Verification of the intermolecular parallel β-sheet in E22K-Aβ42 aggregates by solid-state NMR using rotational resonance : implications for the supramolecular arrangement of the toxic conformer of Aβ422008
- Author(s)
  Y. Masuda, 他2名, 2-3番目, K. Takegoshi, T. Shimizu, T. Shirasawa, *K. Irie
- Journal Title
  
  Biosci. Biotechnol. Biochem. 72
  
  Pages: 2170-2175
- NAID
  10027531218
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208011
[Journal Article] The toxic conformation of the 42-residue amyloid β peptide and its relevance to oxidative stress in Alzheimer's disease2007
- Author(s)
  Kazuhiro Irie
- Journal Title
  
  Mini-Reviews in Medicinal Chemistry 7
  
  Pages: 1001-1008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208011
[Journal Article] Distance measurement between Tyr-10 and Met-35 in amyloid β by site-directed spin labeling ESR : implications for the stronger neurotoxicity of Aβ42 than Aβ402007
- Author(s)
  K. Murakami, H. Hara, Y. Masuda, H. Ohigashi, *K. Irie
- Journal Title
  
  ChemBioChem 8
  
  Pages: 2308-2314
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208011
[Journal Article] Distance Measurement between Tyr-10 and Met-35 in Amyloid (3 by Site-directed Spin Labeling ESR : Implications for the Stronger Neurotoxicity of Aβ342 than Aβ3402007
- Author(s)
  K. Murakami, H. Hara, Y. Masuda, H. Ohigashi, K. Irie
- Journal Title
  
  ChemBioChem 8
  
  Pages: 2308-2314
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208011
[Journal Article] The Toxic Conformation of the 42-residue Amyloid β Peptide and Its Relevance to Oxidative Stress in Alzheimer's Disease.2007
- Author(s)
  K. Irie., K. Murakami,(他5名) K. Takegoshi, H. Fukuda, M. Nagao, T. Shimizu, T. Shirasawa
- Journal Title
  
  Mini-Rev. Med. Chem 7
  
  Pages: 1001-1008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208011
[Journal Article] The toxic conformation of the 42-residue amyloid β peptide and its relevance to oxidative stress in Alzheimer's disease2007
- Author(s)
  *K. Irie., K. Murakami, 他5名, 3-7番目, K. Takeoshi, H. Fukuda, M. Nagao, T. Shimizu, T. Shirasawa
- Journal Title
  
  Mini-Rev. Med. Chem. 7
  
  Pages: 1001-1008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208011
[Journal Article] The toxic conformation of the 42-residue amyloid β peptide and its relevance to oxidative stress in Alzheimer's disease2007
- Author(s)
  Kazuhiro Irie
- Journal Title
  
  Mini-Reviews in Medicinal Chemistry (in press)
- Data Source
  KAKENHI-PROJECT-18208011
[Journal Article] Design and synthesis of 8-octyl-benzolactam-V9, the selective activator for PKCε and η.2006
- Author(s)
  Y.Nakagawa, K.Irie, R.C.Yanagita, H.Ohigashi, K.-i.Tsuda, K.Kashiwagi, N.Saito
- Journal Title
  
  J. Med. Chem. 49 (9)
  
  Pages: 2681-2688
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15208012
[Journal Article] CH/π 相互作用を利用した薬剤開発2006
- Author(s)
  入江一浩
- Journal Title
  
  ファルマシア 42・5
  
  Pages: 427-430
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15208012
[Journal Article] Development of new medicinal leads based on the CH/π interaction.2006
- Author(s)
  K.Irie
- Journal Title
  
  Pharmacia 42 (5)
  
  Pages: 427-430
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15208012
[Journal Article] CH/π相互作用を利用した薬剤開発2006
- Author(s)
  入江一浩
- Journal Title
  
  ファルマシア 42・5
  
  Pages: 427-430
- Data Source
  KAKENHI-PROJECT-15208012
[Journal Article] CH/π相互作用を利用した薬剤開発2006
- Author(s)
  入江一浩
- Journal Title
  
  ファルマシア 42・5
  
  Pages: 427-430
- Data Source
  KAKENHI-PROJECT-18032041
[Journal Article] Structure of β-Amyloid Fibrils and Its Relevance to Their Neurotoxicity : Implications for the Pathogenesis of Alzheimer's Disease2005
- Author(s)
  Kazuhiro Irie
- Journal Title
  
  Journal of Bioscience and Bioengineering 99・5(in press)
- NAID
  110002695685
- Data Source
  KAKENHI-PROJECT-16380080
[Journal Article] Formation and stabilization model of the 42-mer Aβ radical : implications for the long-lasting oxidative stress in Alzheimer's disease.2005
- Author(s)
  K.Murakami, K.Irie, H.Ohigashi, H.Hara, M.Nagao, T.Shimizu, T.Shirasawa
- Journal Title
  
  J.Am.Chem.Soc. 127(43)
  
  Pages: 15168-15174
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16380080
[Journal Article] Toward the development of new medicinal leads with selectivity for protein kinase C isozymes.2005
- Author(s)
  K.Irie, Y.Nakagawa, H.Ohigashi
- Journal Title
  
  Chem. Rec. 5 (4)
  
  Pages: 185-195
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15208012
[Journal Article] Verification of the turn at positions 22 and 23 of the β-amyloid fibrils using solid-state NMR : implication for the pathogenesis of Alzheimer's disease.2005
- Author(s)
  Y.Masuda, K.Irie, K.Murakami, H.Ohigashi, R.Ohashi, K.Takegoshi, T.Shimizu, T.Shirasawa
- Journal Title
  
  Bioorg.Med.Chem. 13(24)
  
  Pages: 6803-6809
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16380080
[Journal Article] Structure of β-amyloid fibrils and its relevance to their neurotixicity : implications for the pathogenesis of Alzheimer's disease2005
- Author(s)
  Kazuhiro Irie
- Journal Title
  
  Journal of Bioscience and Bioengineering 99・5
  
  Pages: 437-447
- Data Source
  KAKENHI-PROJECT-17025051
[Journal Article] Structure of β-amyloid fibrils and its relevance to their neurotoxicity : implications for the pathogenesis of Alzheimer's disease2005
- Author(s)
  Kazuhiro Irie
- Journal Title
  
  Journal of Bioscience and Bioengineering 99・5
  
  Pages: 437-447
- NAID
  110002695685
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16380080
[Journal Article] Toward the development of new medicinal leads with selectivity for protein kinase C isozymes2005
- Author(s)
  Kazuhiro Irie
- Journal Title
  
  The Chemical Record 5・4
  
  Pages: 185-195
- Data Source
  KAKENHI-PROJECT-17035046
[Journal Article] Indolactam-V is involved in the CH/π interaction with Pro-11 of the PKCδ C1B domain : application for the structural optimization of the PKCδ ligand.2005
- Author(s)
  Y.Nakagawa, K.Irie, R.C Yanagita, H.Ohigashi, K.-i.Tsuda
- Journal Title
  
  J. Am. Chem. Soc. 127 (16)
  
  Pages: 5746-5747
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15208012
[Journal Article] Toward the development of new medicinal leads with selectivity for protein kinase C isozymes2005
- Author(s)
  Kazuhiro Irie
- Journal Title
  
  The Chemical Record 5・4
  
  Pages: 185-195
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15208012
[Journal Article] New aggregation model of amyloid β by the systematic proline replacement.2005
- Author(s)
  K.Murakami, K.Irie, A.Morimoto, Y.Masuda, H.Ohigashi, M.Nagao, H.Fukuda, T.Shimizu, T.Shirasawa
- Journal Title
  
  In Peptide Science 2004, Shimohigashi, Y.(Ed.), The Japanese Peptide Society, Fukuoka, Japan
  
  Pages: 179-182
- NAID
  10014459824
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16380080
[Journal Article] Structure of β-amyloid fibrils and its relevance to their neurotoxicity : implications for the pathogenesis of Alzheimer's disease.2005
- Author(s)
  K.Irie, K.Murakami, Y.Masuda, A.Morimoto, H.Ohigashi, R.Ohashi, K.Takegoshi, M.Nagao, T.Shimizu, T.Shirasawa
- Journal Title
  
  J.Biosci.Bioeng. 99(55)
  
  Pages: 437-447
- NAID
  110002695685
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16380080
[Journal Article] Synthesis, conformation and PKC isozyme surrogate binding of indolinelactam-Vs, new conformationally-restricted analogues of (-)-indolactam-V.2004
- Author(s)
  Y.Nakagawa, K.Irie, Y.Komiya, H.Ohigashi, K.-i.Tsuda
- Journal Title
  
  Tetrahedron 60 (33)
  
  Pages: 7077-7084
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15208012
[Journal Article] Tumor promoter binding of the protein kinse C C1 homology domain peptides of RasGRPs, chimaerins, and Unc13s2004
- Author(s)
  Kazuhiro Irie
- Journal Title
  
  Bioorganic ＆ Medicinal Chemistry 12・7
  
  Pages: 4575-4583
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15208012
[Journal Article] ペプチド合成によるホルボールエステル受容体の機能解析2004
- Author(s)
  入江一浩
- Journal Title
  
  化学と生物 42・1
  
  Pages: 54-62
- NAID
  10012135570
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15208012
[Journal Article] Indolactam and benzolactam compounds as new medicinal leads with binding selectivity for C1 domains of protein kinase C isozymes.2004
- Author(s)
  K.Irie, Y.Nakagawa, H.Ohigashi
- Journal Title
  
  Curr. Pharm. Design 10 (12)
  
  Pages: 1371-1385
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15208012
[Journal Article] Indolactam and Benzolactam Compounds as New Medicinal Leads with Binding Selectivity for C1 Domains of Protein Kinase C Isozymes2004
- Author(s)
  Kazuhiro Irie
- Journal Title
  
  Current Pharmaceutical Design 10・12
  
  Pages: 1371-1385
- Data Source
  KAKENHI-PROJECT-15208012
[Journal Article] Analysis of the secondary structure of β-amyloid (Aβ42) fibrils by systematic proline replacement.2004
- Author(s)
  A.Morimoto, K.Irie, K.Murakami, Y.Masuda, H.Ohigashi, M.Nagao, H.Fukuda, T.Shimizu, T.Shirasawa
- Journal Title
  
  J.Biol.Chem. 279(50)
  
  Pages: 52781-52788
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16380080
[Journal Article] Tumor promoter binding of the protein kinase C C1 homology domain peptides of RasGRPs, chimaerins, and Unc13s2004
- Author(s)
  Kazuhiro Irie
- Journal Title
  
  Bioorganic & Medicinal Chemistry 12・17
  
  Pages: 4575-4583
- Data Source
  KAKENHI-PROJECT-15208012
[Journal Article] Tumor promoter binding of the protein kinase C C1 homology domain peptides of RasGRPs, chimaerins, and Unc13s.2004
- Author(s)
  K.Irie, A.Masuda, M.Shindo, Y.Nakagawa, H.Ohigashi
- Journal Title
  
  Bioorg. Med. Chem. 12 (17)
  
  Pages: 4575-4583
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15208012
[Journal Article] Indolactam and benzolactam compounds as new medicinal leads with binding selectivity for C1 domains of protein kinase C isozymes2004
- Author(s)
  Kazuhiro Irie
- Journal Title
  
  Current Pharmaceutical Design 10・12
  
  Pages: 1371-1385
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15208012
[Journal Article] Functional analysis of the phorbol ester receptors using a peptide synthesis.2004
- Author(s)
  K.Irie, H.Ohigashi
- Journal Title
  
  Kagaku to Seibutsu 42 (1)
  
  Pages: 54-62
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15208012
[Journal Article] Analysis of the non-covalent interaction beween metal ions and the cysteine-rich domain of protein kinase C eta by electrospray ionization mass spectrometry.2003
- Author(s)
  M.Shindo, K.Irie, H.Fukuda, H.Ohigashi
- Journal Title
  
  Bioorg. Med. Chem. 11 (23)
  
  Pages: 5075-5082
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15208012
[Journal Article] Synthesis and binding selectivity of 7-and 15-decylbenzolactone-V8 for the C1 domains of protein kinase C isozymes.2003
- Author(s)
  Y.Nakagawa, K.Irie, N.Yamanaka, H.Ohigashi, K.-i.Tsuda
- Journal Title
  
  Bioorg. Med. Chem. Lett. 13 (18)
  
  Pages: 3015-3019
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15208012
[Journal Article] Synthesis and phorbol ester binding of the cysteine-rich domains of diacylglycerol kinase (DGK) isozymes; DGKγ and DGKβ are new targets of tumor-promoting phorbol esters.2003
- Author(s)
  M.Shindo, K.Irie, A.Masuda, H.Ohigashi, Y.Shirai, K.Miyasaka, N.Saito
- Journal Title
  
  J. Biol. Chem. 278 (20)
  
  Pages: 18448-18454
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15208012
[Patent] 抗アミロイドβ４２モノクローナル抗体2021
- Inventor(s)
  入江一浩、松島由佳、入江由美、遠山育夫、景山裕介
- Industrial Property Rights Holder
  入江一浩、松島由佳、入江由美、遠山育夫、景山裕介
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-059059
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-19H00921
[Patent] アミロイドβ42架橋アナログペプチド2020
- Inventor(s)
  入江一浩、松島由佳
- Industrial Property Rights Holder
  入江一浩、松島由佳
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-19H00921
[Patent] アミロイドβの22位及び23位のターン構造を極めて特異的に認識する抗体（学内整理番号：4718）2015
- Inventor(s)
  入江一浩，村上一馬，清水孝彦，泉尾直孝，清藤勉
- Industrial Property Rights Holder
  入江一浩，村上一馬，清水孝彦，泉尾直孝，清藤勉
- Industrial Property Rights Type
  特許
- Filing Date
  2015-12-14
- Overseas
- Data Source
  KAKENHI-PROJECT-26221202
[Patent] アミロイドβの22位及び23位のターン構造を極めて特異的に認識する抗体2014
- Inventor(s)
  入江一浩，村上一馬，清水孝彦，泉尾直孝，清藤　勉
- Industrial Property Rights Holder
  入江一浩，村上一馬，清水孝彦，泉尾直孝，清藤　勉
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-251898
- Filing Date
  2014-12-12
- Data Source
  KAKENHI-PROJECT-26221202
[Patent] 新規アプリシアトキシン誘導体及びそれを含有する抗がん剤2013
- Inventor(s)
  入江一浩，菊森将之，蒲池弘明，柳田亮，中川優
- Industrial Property Rights Holder
  入江一浩，菊森将之，蒲池弘明，柳田亮，中川優
- Industrial Property Rights Type
  特許
- Filing Date
  2013-04-16
- Overseas
- Data Source
  KAKENHI-ORGANIZER-23102001
[Patent] 新規アプリシアトキシン誘導体及びそれを含有する抗がん剤2013
- Inventor(s)
  入江一浩, 菊森将之, 蒲池弘明, 柳田亮, 中川優
- Industrial Property Rights Holder
  国立大学法人京都大学
- Industrial Property Rights Type
  特許
- Filing Date
  2013-04-16
- Acquisition Date
  2017-07-07
- Data Source
  KAKENHI-PLANNED-23102011
[Patent] 新規アプリシアトキシン誘導体及びそれを含有する抗がん剤2012
- Inventor(s)
  入江一浩，菊森将之，蒲池弘明，柳田　亮，中川　優
- Industrial Property Rights Holder
  入江一浩，菊森将之，蒲池弘明，柳田　亮，中川　優
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2012-092842
- Filing Date
  2012-04-16
- Data Source
  KAKENHI-ORGANIZER-23102001
[Patent] 新規アプリシアトキシン誘導体及びそれを含有する抗がん剤2012
- Inventor(s)
  入江一浩，菊森将之，蒲池弘明，柳田　亮，中川　優
- Industrial Property Rights Holder
  入江一浩，菊森将之，蒲池弘明，柳田　亮，中川　優
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2012-092842
- Filing Date
  2012-04-16
- Data Source
  KAKENHI-PLANNED-23102011
[Patent] アミロイド β のターン構造を認識する抗体2011
- Inventor(s)
  入江一浩, 村上一馬, 増田裕一, 清水孝彦,白澤卓二, 清藤勉
- Industrial Property Rights Holder
  入江一浩, 村上一馬, 増田裕一, 清水孝彦,白澤卓二, 清藤勉
- Industrial Property Rights Type
  特許
- Filing Date
  2011-04-21
- Overseas
- Data Source
  KAKENHI-PROJECT-21248015
[Patent] Antibody recognizing tumstructure in amyloid β2010
- Inventor(s)
  Kazuhiro Irie, Kazuma Murakami, Yuichi Masuda, Takahiko Shimizu, Takuji Shirasawa, Tsutomu Seito
- Industrial Property Rights Holder
  Kazuhiro Irie, Kazuma Murakami, Yuichi Masuda, Takahiko Shimizu, Takuji Shirasawa, Tsutomu Seito
- Industrial Property Rights Type
  特許
- Filing Date
  2010-10-18
- Acquisition Date
  2014-04-29
- Overseas
- Data Source
  KAKENHI-PROJECT-21248015
[Patent] アミロイドβのターン構造を認識する抗体2009
- Inventor(s)
  入江一浩, 他5名
- Industrial Property Rights Holder
  入江一浩, 他5名
- Industrial Property Number
  2009-239542
- Filing Date
  2009-10-16
- Data Source
  KAKENHI-PROJECT-21248015
[Patent] βアミロイド、及びそれを用いたアルツハイマー病治療薬又は予防薬のスクリーニング方法2005
- Inventor(s)
  入江一浩他5名
- Industrial Property Rights Holder
  入江一浩他5名
- Industrial Property Number
  2005-087184
- Filing Date
  2005-03-24
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16380080
[Patent] βアミロイド、及びそれを用いたアルツハイマー病治療薬又は予防薬のスクリーニング方法2005
- Inventor(s)
  入江一浩, 他5名
- Industrial Property Rights Holder
  入江一浩, 他5名
- Industrial Property Number
  2005-087184
- Filing Date
  2005-03-24
- Data Source
  KAKENHI-PROJECT-16380080
[Patent] βアミロイド、及びそれを用いたアルツハイマー病治療薬又は予防薬のスクリーニング方法2005
- Inventor(s)
  入江一浩他5名
- Industrial Property Rights Holder
  入江一浩他5名
- Industrial Property Number
  2005-087184
- Filing Date
  2005-03-24
- Data Source
  KAKENHI-PROJECT-17025051
[Patent] βアミロイド, 及びそれを用いたアルツハイマー病治療薬又は予防薬のスクリーニング方法2005
- Inventor(s)
  入江一浩, 村上一馬, 大東肇, 永尾雅哉, 白澤卓二, 清水孝彦
- Industrial Property Rights Holder
  入江一浩, 村上一馬, 大東肇, 永尾雅哉, 白澤卓二, 清水孝彦
- Patent Publication Number
  2006-265189
- Filing Date
  2005-03-24
- Data Source
  KAKENHI-PROJECT-18208011
[Patent] βアミロイド,及びそれを用いたアルツハイマ-病治療薬又は予防薬のスクリ-ニング方法2005
- Inventor(s)
  入江一浩, 村上一馬, 大東肇, 永尾雅哉, 白澤卓二, 清水孝彦
- Industrial Property Rights Holder
  入江一浩, 村上一馬, 大東肇, 永尾雅哉, 白澤卓二, 清水孝彦
- Patent Publication Number
  2006-265189
- Filing Date
  2005-03-24
- Data Source
  KAKENHI-PROJECT-18208011
[Presentation] 病原性凝集ペプチドの3量体モデルのリンカーとなるアルキル架橋トリス-α-アミノ酸の合成2021
- Author(s)
  内野歩美、塚野千尋、今本恒雄、入江一浩
- Organizer
  日本農芸化学会2021年度大会（オンライン開催）
- Data Source
  KAKENHI-PROJECT-19H00921
[Presentation] 分子内ジスルフィド結合形成によるアミロイド β42毒性配座固定モデルの合成および活性評価2021
- Author(s)
  松島由佳、柳田　亮、入江一浩
- Organizer
  第39回日本認知症学会学術集会（オンライン開催）
- Data Source
  KAKENHI-PROJECT-19H00921
[Presentation] 分子内ジスルフィド結合形成によるアミロイドβ42の毒性配座モデルの最適化2021
- Author(s)
  松島由佳、入江一浩
- Organizer
  日本農芸化学会関西支部例会（第514回講演会、オンライン開催）
- Data Source
  KAKENHI-PROJECT-19H00921
[Presentation] CH/π相互作用に着目したAplysiatoxin単純化アナログの分子動力学解析2021
- Author(s)
  柳田亮、小林巧美、権田敦子、高田晃児、入江一浩
- Organizer
  日本農芸化学会2021年度大会（オンライン開催）
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] B環を除去したAplysiatoxin単純化アナログの合成研究2021
- Author(s)
  山本剛資、柳田　亮、川浪康弘、入江一浩
- Organizer
  日本農芸化学会中四国支部第58回講演会（オンライン開催）
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] Debromoaplysiatoxin単純化アナログ・10-Me-Aplog-1の側鎖長の最適化2020
- Author(s)
  権田敦子、高田晃児、入江一浩
- Organizer
  2020年度日本農芸化学会大会（九州大学、福岡市）
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] CH/π相互作用に着目したaplysiatoxin単純化アナログの合成と生物活性2020
- Author(s)
  小林巧実、入江一浩
- Organizer
  2020年度日本農芸化学会大会（九州大学、福岡市）
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] アミロイドβの凝集を抑制する食品・生薬成分の作用機構2019
- Author(s)
  入江一浩、村上一馬
- Organizer
  2019年度日本農芸化学会大会（東京農大、東京）
- Invited
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] 新規PKCリガンドの開発とHIVのShock & Kill療法への応用2019
- Author(s)
  入江一浩
- Organizer
  新学術領域研究（化学コミュニ）第6回公開シンポジウム（慶應義塾大学、横浜市）
- Invited
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] スピロ環を簡略化したアプリシアトキシン単純化アナログの合成，配座，および生物活性2019
- Author(s)
  柳田亮、芦田能基、川浪康弘、旦慎吾、岡村睦美、入江一浩
- Organizer
  2018年度先端モデル動物支援プラットフォーム成果発表会（琵琶湖ホテル、大津市）
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] アミロイドβの毒性配座理論を基盤としたアルツハイマー病の予防戦略2019
- Author(s)
  入江一浩
- Organizer
  日本農芸化学会東北支部2019年度大会（弘前大学、弘前市）
- Invited
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] 準安定なアミロイドβの毒性オリゴマーモデルの合成と機能解析2019
- Author(s)
  入江由美、村上一馬、花木瑞穂、花木祐輔、鈴木天志、今本恒雄、古田　巧、川端猛夫、川瀬泰司、廣瀬賢治、柳田　亮、入江一浩
- Organizer
  第61回天然有機化合物討論会（広島国際会議場、広島市）
- Data Source
  KAKENHI-PROJECT-19H00921
[Presentation] アミロイドβの毒性配座理論を基盤としたアルツハイマー病の予防戦略2019
- Author(s)
  入江一浩
- Organizer
  2019年度日本農芸化学会大会（東京農大、東京）日本農芸化学会賞受賞講演
- Invited
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] スピロ環をもたないaplysiatoxin単純化アナログの合成とPKCアイソザイム結合活性2019
- Author(s)
  押村亜沙美、早川皓太郎、花木祐輔、柳田亮、入江一浩
- Organizer
  2019年度日本農芸化学会大会（東京農大、東京）
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] Synthesis, conformation, and biological activities of a des-A-ring analog of 18-deoxy-aplog-1, a simplified analog of debromoaplysiatoxin2019
- Author(s)
  Ashida Yoshiki、Yanagita Ryo C.、Kawanami Yasuhiro、Okamura Mutsumi、Dan Shingo、Irie Kazuhiro
- Organizer
  新学術領域研究「化学コミュニケーションのフロンティア」第1回国際シンポジウム（一橋大学一橋講堂、東京）
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] アミロイドβ40の3量体モデルの合成と神経細胞毒性2019
- Author(s)
  入江由美、花木瑞穂、村上一馬、今本恒雄、古田　巧、川端猛夫、川瀬泰司、廣瀬賢治、柳田　亮、入江一浩
- Organizer
  第38回日本認知症学会学術集会（京王プラザホテル、東京）
- Data Source
  KAKENHI-PROJECT-19H00921
[Presentation] アミロイドβの毒性配座理論を基盤としたアルツハイマー病の予防戦略2019
- Author(s)
  入江一浩
- Organizer
  日本農芸化学会関西・中部支部2019年度合同神戸大会（神戸大学、神戸市）
- Invited
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] アミロイドβ42の毒性オリゴマーに対する核酸アプタマーの開発研究と脳組織染色への応用2019
- Author(s)
  村上一馬、小畑弥生、関川あさ、上田遥、泉尾直孝、粟野達也、高部圭司、清水孝彦、入江一浩
- Organizer
  2019年度日本農芸化学会大会（東京農大、東京）優秀発表
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アミロイドβの毒性配座理論を基盤としたアルツハイマー病の予防戦略2019
- Author(s)
  入江一浩
- Organizer
  日本農芸化学会東北支部2019年度大会（弘前大学、弘前市）
- Invited
- Data Source
  KAKENHI-PROJECT-19H00921
[Presentation] 分子内ジスルフィド結合によるアミロイドβ 42の毒性配座固定アナログの合成と生化学的機能解析2019
- Author(s)
  松島由佳、村上一馬、入江一浩
- Organizer
  第9回認知症研究を知る若手研究者の集まり(ホテルヘリテイジ・リゾート、熊谷市）
- Data Source
  KAKENHI-PROJECT-19H00921
[Presentation] サンゴジュの花芽に含まれるビブサニン類の分析と生物活性評価2019
- Author(s)
  柳田亮、植松紗和子、西皓冬、川浪康弘、入江一浩
- Organizer
  2019年度日本農芸化学会大会（東京農大、東京）
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] 分子内ジスルフィド結合形成によるアミロイドβ42の毒性配座モデルの合成と機能解析2019
- Author(s)
  松島由佳、村上一馬、花木瑞穂、粟野達也、高部圭司、柳田亮、入江一浩
- Organizer
  2019年度日本農芸化学会大会（東京農大、東京）
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アミロイドβの毒性配座理論を基盤としたアルツハイマー病の予防戦略2019
- Author(s)
  入江一浩
- Organizer
  日本農芸化学会関西・中部支部2019年度合同神戸大会（神戸大学、神戸市）
- Invited
- Data Source
  KAKENHI-PROJECT-19H00921
[Presentation] Evaluation system of amyloid beta precursor protein processing in rat primary cortical neurons treated with PKC activators2019
- Author(s)
  Yoshimura Mayuko、Murakami Kazuma、Kume Toshiaki、Irie Kazuhiro
- Organizer
  新学術領域研究「化学コミュニケーションのフロンティア」第1回国際シンポジウム（一橋大学一橋講堂、東京）
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] アミロイドβの毒性配座理論を基盤としたアルツハイマー病の予防戦略2019
- Author(s)
  入江一浩
- Organizer
  2019年度日本農芸化学会大会（東京農大、東京）日本農芸化学会賞受賞講演
- Invited
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] PKC活性化剤とBET阻害剤の併用によるHIV再活性化能及び毒性への効果2019
- Author(s)
  鷲崎彩夏、村田めぐみ、関　洋平、Yin Pui Tang、Tan Wei Keat、入江一浩、明里宏文
- Organizer
  第33回日本エイズ学会学術集会・総会（熊本城ホール、熊本市）
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] アミロイドβの毒性オリゴマーの構造解析に基づくアルツハイマー病の早期診断法の開発2018
- Author(s)
  入江一浩
- Organizer
  2018年度日本農芸化学会大会（名城大学、名古屋市）
- Invited
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アプリシアトキシン単純化アナログのがん細胞増殖抑制活性2018
- Author(s)
  入江一浩
- Organizer
  先端モデル動物支援プラットフォーム　成果発表会2017（琵琶湖ホテル、大津市）
- Invited
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] アプリシアトキシン単純化アナログ・10-Me-Aplog-1の3位アセタール型アナログの合成2018
- Author(s)
  早川皓太郎、花木祐輔、徳田春邦、柳田亮、中川優、入江一浩
- Organizer
  2018年度日本農芸化学会大会（名城大学、名古屋市）
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] A Novel PKC activator 10-methyl-aplog-1 in combination with JQ1 showed high potency as LRA for shock and kill therapy2018
- Author(s)
  Washizaki Ayaka、Murata Megumi、Seki Yohei、Yin Pui Tang、Kangawa Hiroyuki、Tan Wei Keat、Irie Kazuhiro、Akari Hirofumi
- Organizer
  36th Annual Symposium on Nonhuman Primate Models for AIDS (Bell Harbor International Conference Center, Washington, USA)
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] サンゴジュに含まれるビブサニン類のプロテインキナーゼC結合活性の評価と結合様式の予測2018
- Author(s)
  植松紗和子、柳田亮、三宅翔太、川浪康弘、入江一浩
- Organizer
  日本農芸化学会2018年度中四国支部大会（島根大学松江キャンパス、松江市）
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] Aplysiatoxin 単純化アナログ・10-Methyl-aplog-1のがん細胞増殖抑制に関わるPKCアイソザイムの同定2018
- Author(s)
  花木祐輔、四方雄貴、菊森将之、堀田夏紀、井本正哉、入江一浩
- Organizer
  2018年度日本農芸化学会大会（名城大学、名古屋市）
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] 分子内ジスルフィド結合形成によるアミロイドβの毒性コンホメーションの制御2018
- Author(s)
  松島由佳、村上一馬、花木瑞穂、粟野達也、高部圭司、柳田亮、入江一浩
- Organizer
  第37回日本認知症学会学術集会（ロイトン札幌・札幌市教育文化会館、札幌市）
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アプリシアトキシン単純化アナログ・10-Me-Aplog-1の構造最適化とがん細胞増殖抑制に関わるPKCアイソザイムの同定2018
- Author(s)
  入江一浩
- Organizer
  新学術領域研究「化学コミュニケーションのフロンティア」第2回公開シンポジウム（益川ホール、京都市）
- Invited
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] 新規PKC活性化剤10-Methyl-Aplog-1とJQ1の併用はLatency Reversing Agentとして理想的な活性を示す2018
- Author(s)
  鷲崎彩夏、村田めぐみ、関洋平、Yin Pui Tang、寒川裕之、Tan Wei Keat、入江一浩、明里宏文
- Organizer
  第32回日本エイズ学会学術集会・総会（大阪国際会議場・大阪市中央公会堂、大阪市）
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] アプリシアトキシン単純化アナログ・10-Me-aplog-1の側鎖誘導体の合成と活性2018
- Author(s)
  高田晃児、花木祐輔、菊森将之、徳田春邦、柳田亮、入江一浩
- Organizer
  2018年度日本農芸化学会大会（名城大学、名古屋市）
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] 青ジソに含まれるアミロイドβ42の凝集阻害物質の作用機構とマウスにおける生体内代謝2018
- Author(s)
  坂口嘉紀、村上一馬、花木瑞穂、泉尾直孝、小澤祐介、粟野達也、高部圭司、川瀬泰司、廣瀬賢治、三羽伸明、久米利明、清水孝彦、入江一浩
- Organizer
  2018年度日本農芸化学会大会（大会トピックス賞）（名城大学、名古屋市）
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] スピロ環をもたないアプリシアトキシン単純化アナログの合成、配座、および活性2018
- Author(s)
  芦田能基、柳田亮、川浪康弘、入江一浩
- Organizer
  2018年度日本農芸化学会大会（名城大学、名古屋市）
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] アミロイドβ42の毒性2量体モデルから形成されるプロトフィブリルを標的としたRNAアプタマーの開発2018
- Author(s)
  小畑弥生、村上一馬、関川あさ、入江一浩
- Organizer
  2018年度日本農芸化学会大会（名城大学、名古屋市）
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アミロイドβ42の2量体モデル由来の毒性オリゴマーに対するRNAアプタマー2018
- Author(s)
  小畑弥生、村上一馬、関川あさ、粟野達也、髙部圭司、入江一浩
- Organizer
  日本核酸医薬学会第4回年会（九州大学医学部百年講堂、福岡市）
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アポモルフィンによるアミロイドβ42凝集抑制機構の解析2018
- Author(s)
  花木瑞穂、村上一馬、片山寿美枝、赤木謙一、入江一浩
- Organizer
  2018年度日本農芸化学会大会（名城大学、名古屋市）
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] 抗腫瘍性Aplysiatoxin単純化アナログ・10-Me-Aplog-1のアセタール型アナログの合成と生物活性2018
- Author(s)
  早川皓太郎、花木祐輔、徳田春邦、柳田亮、中川優、入江一浩
- Organizer
  第60回天然有機化合物討論会（久留米シティープラザ、福岡県久留米市）
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] RNA aptamers targeting the toxic oligomers of Aβ42 and their application to immunohistochemistry2018
- Author(s)
  Murakami Kazuma、Obata Yayoi、Sekikawa Asa、Ueda Haruka、Izuo Naotaka、Awano Tatsuya、Takabe Keiji、Shimizu Takahiko、Irie Kazuhiro
- Organizer
  The 45th International Symposium on Nucleic Acids Chemistry (Kyoto University Clock Tower Centennial Hall, Kyoto, Japan)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] 漢方由来ウンカリン酸 C によるアミロイド β42 核形成阻害メカニズム2017
- Author(s)
  吉岡卓也、村上一馬、花木瑞穂、緑川諭弘、谷脇慎治、郡司祐樹、川瀬泰司、廣瀬賢治、入江一浩
- Organizer
  2017年度日本農芸化学会大会
- Place of Presentation
  京都女子大学（京都府京都市）
- Year and Date
  2017-03-20
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アミロイドβの毒性配座理論と抗体創製2017
- Author(s)
  村上一馬、入江一浩
- Organizer
  認知症研究を知る若手研究者の集まり2017（湯の宿木もれび、大津市）
- Invited
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] イオンモビリティー質量分析計を用いたアミロイドβオリゴマーの測定2017
- Author(s)
  入江一浩
- Organizer
  第65回質量分析総合討論会（つくば国際会議場、つくば市）
- Invited
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アミロイドβ40の毒性オリゴマーモデル2017
- Author(s)
  入江由美、村上一馬、花木瑞穂、花木祐輔、鈴木天志、物部容子、高井朋代、赤木謙一、川瀬泰司、廣瀬賢治、入江一浩
- Organizer
  2017年度日本農芸化学会大会
- Place of Presentation
  京都女子大学（京都府京都市）
- Year and Date
  2017-03-20
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] オリゴマー仮説の視点からバイオマーカーを考える：アミロイドβの毒性配座理論2017
- Author(s)
  村上一馬、入江一浩
- Organizer
  第36回日本認知症学会学術集会（ANAクラウンプラザホテル金沢、金沢市）
- Invited
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アミロイドβ「毒性コンホマー」を標的にしたアルツハイマー病の治療・診断法の開発2017
- Author(s)
  泉尾直孝、久米利明、村上一馬、徳田隆彦、前田雅弘、入江一浩、清水孝彦
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2017-03-25
- Invited
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] 生薬チョウトウコウに含まれるアミロイドβオリゴマー形成阻害物質の同定と作用機構2017
- Author(s)
  村上一馬、吉岡卓也、井戸恭平、花木瑞穂、山口加乃子、緑川諭弘、谷脇慎治、郡司祐樹、赤木謙一、川瀬泰司、廣瀬賢治、入江一浩
- Organizer
  第59回天然有機化合物討論会（札幌市民ホール、札幌市）
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] A Novel PKC activator, 10-methyl-aplog-1, induces HIV-1 efficiently in combination with BET inhibitor JQ12017
- Author(s)
  Ayaka Washizaki, Megumi Murata, Yohei Seki, Yin Pui Tang, Kazuhiro Irie, Hirofumi Akari
- Organizer
  35th Annual Symposium on Nonhuman Primate Models for AIDS (Madison, USA)
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] 神経細胞毒性を有する準安定なアミロイドβの2量体モデルの合成とイオンモビリティー質量分析法による構造解析2017
- Author(s)
  入江一浩、入江由美、村上一馬、花木瑞穂、花木祐輔、川瀬泰司、廣瀬賢治、徳田隆彦、前田雅弘
- Organizer
  第35回メディシナルケミストリーシンポジウム（豊田講堂、名古屋市）
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アミロイドβの毒性2量体モデルの合成とイオンモビリティー質量分析法による構造解析2017
- Author(s)
  入江一浩
- Organizer
  京都大学学際融合教育研究推進センター・生理化学研究ユニット第7回公開シンポジウム（京都大学農学部総合館、京都市）
- Invited
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] 新規PKC activator、10-Methyl-Aplog-1はHIV-1を再活性化する有用なLatency Reversing Agentである2017
- Author(s)
  鷲崎彩夏、村田めぐみ、関洋平、Yin Pui Tang、寒川裕之、入江一浩、明里宏文
- Organizer
  第31回日本エイズ学会学術集会・総会（中野サンプラザ、東京都）
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] 新規PKC activatorである10-methyl-aplog-1はHIV-1再活性化薬として有用である2017
- Author(s)
  鷲崎彩夏、村田めぐみ、関洋平、Yin Pui Tang、寒川裕之、入江一浩、明里宏文
- Organizer
  第65回日本ウイルス学会学術集会（大阪国際会議場、大阪市）
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] アミロイドβのラジカル化：アルツハイマー病態におけるSOD1の役割2016
- Author(s)
  村上一馬、清水孝彦、入江一浩
- Organizer
  第11回レドックス・ライフイノベーションシンポジウム
- Place of Presentation
  お茶の水女子大学（東京都文京区）
- Year and Date
  2016-03-17
- Invited
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] 天然ポリフェノールによるAβ42凝集阻害機構の解明とアルツハイマー病予防の可能性2016
- Author(s)
  村上一馬、入江一浩
- Organizer
  第35回日本認知症学会学術集会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Year and Date
  2016-12-03
- Invited
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] ウンカリン酸によるアミロイドβ凝集核形成の選択的阻害2016
- Author(s)
  吉岡卓也、村上一馬、井戸恭平、花木瑞穂、山口加乃子、緑川諭弘、谷脇慎治、郡司祐樹、入江一浩
- Organizer
  第35回日本認知症学会学術集会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Year and Date
  2016-12-02
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] Characterization of the monoclonal antibody (24B3) highly recognizing the toxic turn of amyloid β42 and its application to diagnosis for Alzheimer’s disease2016
- Author(s)
  Kazuma Murakami, Mizuho Hanaki, Maki Tokuda, Ken-ichi kagi, Ryotaro Ishii, Harutsugu Tatebe, Takahiko Tokuda, Masahiro Maeda, Naotaka Izuo, Takahiko Shimizu, Kazuhiro Irie
- Organizer
  The 8th Takeda Science Foundation Symposium on PharmaSciences “Biomolecule-based Medicinal Science: Featuring Mid-Size Drugs”
- Place of Presentation
  Takeda Pharmaceutical Company, Ltd. (Suita, Japan)
- Year and Date
  2016-01-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] Passive immunization with the toxic conformer of Aβ ameliorated behavioral abnormalities in Alzheimer’s-like model without affecting senile plaque deposition2016
- Author(s)
  泉尾直孝、村上一馬、久米利明、入江一浩、横手幸太郎、清水孝彦
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-10
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] チョウトウコウに含まれるウンカリン酸Ｃおよびその誘導体のアミロイドβ凝集阻害活性2016
- Author(s)
  吉岡卓也、村上一馬、花木瑞穂、緑川諭弘、谷脇慎治、郡司裕樹、入江一浩
- Organizer
  2016年度日本農芸化学会大会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2016-03-28
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アミロイドβの毒性コンホマーにきわめて特異的な抗体の開発とアルツハイマー病診断への応用2016
- Author(s)
  村上一馬、徳田真樹、鈴木天志、入江由美、花木瑞穂、柳田亮、物部容子、赤木謙一、石井亮太郎、建部陽嗣、徳田隆彦、前田雅弘、久米利明、泉尾直孝、清水孝彦、入江一浩
- Organizer
  2016年度日本農芸化学会大会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2016-03-28
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] Aβ42の22-23位におけるターン構造はAβ42誘発神経毒性を調節する2016
- Author(s)
  泉尾直孝、久米利明、村上一馬、前田雅弘、入江一浩、清水孝彦
- Organizer
  日本基礎老化学会大会
- Place of Presentation
  伊勢原市民文化会館（神奈川県伊勢原市）
- Year and Date
  2016-05-27
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アミロイドβ40の2量体モデルの合成と神経細胞毒性2016
- Author(s)
  入江由美、村上一馬、鈴木天志、花木瑞穂、花木祐輔、物部容子、高井朋代、赤木謙一、入江一浩
- Organizer
  第35回日本認知症学会学術集会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Year and Date
  2016-12-02
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] Identification of the “toxic conformer” of amyloid β and its pathogenic contribution of Alzheimer's disease2016
- Author(s)
  Naotaka Izuo, Kazuma Murakami, Toshiaki Kume, Masahiro Maeda, Kazuhiro Irie, Takahiko Shimizu
- Organizer
  2016 Spring International Conference of the Korean Society for Gerontology
- Place of Presentation
  Convention Hall (Daegu, Korea)
- Year and Date
  2016-06-16
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アミロイドβの毒性コンホマーを極めて特異的に認識する抗体の開発とAD診断への応用2015
- Author(s)
  村上一馬、花木瑞穂、赤木謙一、石井亮太郎、徳田隆彦、前田雅弘、泉尾直孝、清水孝彦、入江一浩
- Organizer
  第34回日本認知症学会学術集会
- Place of Presentation
  リンクステーションホール青森（青森県青森市）
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アプリシアトキシンの構造単純化による抗がん剤シーズの開発研究2015
- Author(s)
  入江一浩
- Organizer
  第33回メディシナルケミストリーシンポジウム
- Place of Presentation
  幕張国際研修センター（千葉市）
- Year and Date
  2015-11-26
- Invited
- Data Source
  KAKENHI-PLANNED-23102011
[Presentation] アミロイドβペプチドの毒性配座理論に基づいた構造特異抗体の開発と診断薬への応用2015
- Author(s)
  村上一馬、入江一浩
- Organizer
  第47回若手ペプチド夏の勉強会
- Place of Presentation
  信州塩尻・天然温泉アスティかたおか（長野県塩尻市）
- Year and Date
  2015-08-11
- Invited
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アミロイドβ42ダイマーの合成と活性評価2015
- Author(s)
  徳田真樹、村上一馬、鈴木天志、花木瑞穂、岩崎真実、久米利明、入江一浩
- Organizer
  2015年度日本農芸化学会大会
- Place of Presentation
  岡山大学津島キャンパス（岡山市）
- Year and Date
  2015-03-27
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] Inhibitory mechanism for amyloid β42 aggregation by flavonoids2015
- Author(s)
  Kazuhiro Irie
- Organizer
  The 2nd Kyoto-Bordeaux Symposium 2015
- Place of Presentation
  Kyoto University (Kyoto, Japan)
- Year and Date
  2015-05-22
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] Structural insight into the inhibitory mechanism of amyloid β42 aggregation by non-catechol-type flavonoids2015
- Author(s)
  Mizuho Hanaki, Kazuma Murakami, Ken-ichi Akagi, Kazuhiro Irie
- Organizer
  2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015)
- Place of Presentation
  Hilton Hawaiian Villege (Honolulu, USA)
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] Aβ 毒性コンホマーの選択的除去は老人斑に影響せずアルツハイマー病症状を改善する2015
- Author(s)
  泉尾直孝、村上一馬、前田雅弘、久米利明、横手幸太郎、入江一浩、清水孝彦
- Organizer
  第34回日本認知症学会学術集会
- Place of Presentation
  リンクステーションホール青森（青森県青森市）
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アミロイドβの「毒性コンホマー」を標的とした受動免疫療法はアルツハイマー病モデルの神経症状を改善する2015
- Author(s)
  泉尾直孝、村上一馬、徳田隆彦、久米利明、赤池昭紀、白澤卓二、横手幸太郎、入江一浩、清水孝彦
- Organizer
  日本基礎老化学会大会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2015-06-13
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アミロイドβの毒性配座理論に基づいた構造特異抗体の開発と診断薬への応用2015
- Author(s)
  村上一馬、入江一浩
- Organizer
  第8回たんぱく質の異常凝集とその防御・修復機構に関する研究会
- Place of Presentation
  京都大学原子炉実験所（大阪府熊取町）
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] SOFAST-HMQC NMR を用いた非カテコール型フラボノイドによるアミロイドβの凝集抑制機構の解析2015
- Author(s)
  花木瑞穂、村上一馬、赤木謙一、入江一浩
- Organizer
  2015年度日本農芸化学会中部・関西支部合同大会
- Place of Presentation
  富山県立大学（富山県射水市）
- Year and Date
  2015-09-20
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] Aplysiatoxin 単純化アナログのアミド誘導体の合成と活性2015
- Author(s)
  花木祐輔、柳田　亮、菅原貴弘、相田美砂子、徳田春邦、鈴木信孝、入江一浩
- Organizer
  2015年度日本農芸化学会大会
- Place of Presentation
  岡山大学津島キャンパス（岡山市）
- Year and Date
  2015-03-27
- Data Source
  KAKENHI-PLANNED-23102011
[Presentation] Extraction of anti-proliferative activity from pleiotropic debromoaplysiatoxin, a potent tumor promoter and a highly inflammatory principle isolated from sea hare2015
- Author(s)
  K. Irie et al.
- Organizer
  2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015)
- Place of Presentation
  Hilton Hawaiian Village (Hawaii, USA)
- Year and Date
  2015-12-15
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23102011
[Presentation] Characterization of monoclonal antibodies against the toxic turn of amyloid β42 and their application to diagnosis for Alzheimer’s disease2015
- Author(s)
  Kazuma Murakami, Mizuho Sato-Hanaki, L. M. Moro, G. Giaccone, F. Tagliavini, Ken-ichi Akagi, Ryotaro Ishii, Takahiko Tokuda, Masahiko Maeda, Naotaka Izuo, Takahiko Shimzu, Kazuhiro Irie
- Organizer
  2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015)
- Place of Presentation
  Hilton Hawaiian Villege (Honolulu, USA)
- Year and Date
  2015-12-15
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] AplysiatoxinのPKC C1ドメイン認識部位の構造活性相関研究2015
- Author(s)
  芦田能基、柳田　亮、川浪康弘、入江一浩
- Organizer
  2015年度日本農芸化学会大会
- Place of Presentation
  岡山大学津島キャンパス（岡山市）
- Year and Date
  2015-03-27
- Data Source
  KAKENHI-PLANNED-23102011
[Presentation] 天然のプロテインキナーゼＣリガンドの単純化による抗がん剤シーズの開発研究2015
- Author(s)
  入江一浩
- Organizer
  日本農芸化学会2015年度中四国・西日本支部合同大会
- Place of Presentation
  愛媛大学農学部（樽味キャンパス，松山市）
- Year and Date
  2015-09-17
- Invited
- Data Source
  KAKENHI-PLANNED-23102011
[Presentation] Aβ毒性コンホマーの選択的除去は老人班蓄積を阻害せずにアルツハイマー病モデルマウスの行動異常を改善する2015
- Author(s)
  泉尾直孝、村上一馬、前田雅弘、久米利明、横手幸太郎、入江一浩、清水孝彦
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-04
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] 非カテコール型フラボノイドによるアミロイドβの凝集抑制機構2015
- Author(s)
  花木瑞穂、村上一馬、赤木謙一、入江一浩
- Organizer
  第57回天然有機化合物討論会
- Place of Presentation
  神奈川県民ホール（神奈川県横浜市）
- Year and Date
  2015-09-09
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] Pathophysiological activities of the “toxic conformer” and the “non-toxic conformer” of amyloid β-induced neurotoxicity2015
- Author(s)
  泉尾直孝、久米利明、村上一馬、入江一浩、泉安彦、赤池昭紀、横手幸太郎、清水孝彦
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋国際会議場（名古屋市）
- Year and Date
  2015-03-19
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] Synthesis and biological activities of the Abeta40 dimer with toxic conformation2014
- Author(s)
  Kazuhiro Irie, Kazuma Murakami, Takashi Suzuki, Mizuho Sato, Mami Iwasaki, Toshiaki Kume
- Organizer
  Alzheimer’s Association International Conference 2014
- Place of Presentation
  Bella Center A/S (Copenhagen, Denmark)
- Year and Date
  2014-07-14
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] 植物由来ポリフェノールのアミロイドβ凝集阻害活性2014
- Author(s)
  高瀬　澪、木立恵利、栗栖真奈美、竹田亜矢、中曽根理絵、宮前友策、村上一馬、入江一浩、繁森英幸
- Organizer
  新規素材探索研究会第13回セミナー
- Place of Presentation
  新横浜フジビューホテル、横浜
- Year and Date
  2014-06-06
- Data Source
  KAKENHI-PROJECT-24580156
[Presentation] 抗がん剤開発を指向した新規プロテインキナーゼＣリガンドの創製2014
- Author(s)
  入江一浩
- Organizer
  京都大学学際融合教育研究推進センター・生理化学研究ユニット第4回公開シンポジウム
- Place of Presentation
  京都大学益川記念館（京都市）
- Year and Date
  2014-06-24
- Invited
- Data Source
  KAKENHI-PLANNED-23102011
[Presentation] アプリシアトキシン単純化アナログ（Aplog-1）の抗がん剤シーズとしての構造最適化2014
- Author(s)
  菊森将之、柳田　亮、中川　優、蒲池弘明、徳田春邦、鈴木信孝、入江一浩
- Organizer
  新学術領域研究・がん支援「化学療法基盤支援活動」第3回シンポジウム
- Place of Presentation
  万国津梁館（沖縄県、名護市）
- Year and Date
  2014-05-12
- Data Source
  KAKENHI-PLANNED-23102011
[Presentation] Synthesis and biological activities of the simplified analogs of a natural PKC ligand aplysiatoxin2013
- Author(s)
  Kazuhiro irie
- Organizer
  International Symposium on Natural Products Chemistry and Chemical Biology 2013
- Place of Presentation
  , Nagoya, Japan
- Invited
- Data Source
  KAKENHI-ORGANIZER-23102001
[Presentation] 植物由来カフェ酸誘導体のアミロイドβ凝集阻害活性に関する研究2013
- Author(s)
  木立恵利、栗栖真奈美、宮前友策、村上一馬、入江一浩、繁森英幸
- Organizer
  第3回植物生理科学研究会
- Place of Presentation
  神戸天然物化学株式会社バイオリサーチセンター、神戸
- Data Source
  KAKENHI-PROJECT-24580156
[Presentation] Vitamin C and silymarin restores Aβ oligomerization and behavioral abnormality in Alzheimer's pathology2013
- Author(s)
  Murakami, K., Murata, N., Ozawa, Y., Irie, K., Shirasawa, T., Shimizu, T
- Organizer
  Alzheimer's Association International Conference (AAIC) 2013
- Place of Presentation
  Boston, USA
- Year and Date
  2013-07-15
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] ポリフェノールによるアミロイド β の凝集抑制機構2013
- Author(s)
  入江一浩
- Organizer
  2013年度日本農芸化学会大会シンポジウム
- Place of Presentation
  仙台
- Year and Date
  2013-03-27
- Invited
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] 食品由来カフェオイルキナ酸の神経細胞保護効果2013
- Author(s)
  繁森英幸、宮前友策、栗栖真奈美、村上一馬、入江一浩、韓　準きゅ、礒田博子
- Organizer
  第11回日本機能性食品医用学会総会
- Place of Presentation
  東京海洋大学、東京
- Data Source
  KAKENHI-PROJECT-24580156
[Presentation] 植物由来カフェ酸誘導体のアミロイドβ凝集阻害活性に関する研究2013
- Author(s)
  木立恵利、栗栖真奈美、宮前友策、村上一馬、入江一浩、繁森英幸
- Organizer
  新規素材探索研究会第12回セミナー
- Place of Presentation
  新横浜フジビューホテル、横浜
- Data Source
  KAKENHI-PROJECT-24580156
[Presentation] ポリフェノールによるアミロイドβ の凝集阻害機構2012
- Author(s)
  入江一浩, 村上一馬, 佐藤瑞穂, 井久保遥子, 宇野真弓, 中川優, 片山寿美枝, 赤木謙一
- Organizer
  第31回日本認知症学会学術集会
- Place of Presentation
  つくば
- Year and Date
  2012-10-28
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] プロテインキナーゼＣを標的とした新規抗がん剤シーズ2012
- Author(s)
  入江　一浩
- Organizer
  京都大学新技術説明会（招待講演）
- Place of Presentation
  JST東京別館ホール（東京、市ヶ谷）
- Invited
- Data Source
  KAKENHI-ORGANIZER-23102001
[Presentation] 日本産フサコケムシに含まれるブリオスタチン類の同定と活性評価2012
- Author(s)
  植野紗代,柳田亮,村上一馬,村上明,徳田春邦,鈴木信孝,藤原健史,入江一浩
- Organizer
  日本農芸化学会2012年度大会
- Place of Presentation
  京都
- Year and Date
  2012-03-23
- Data Source
  KAKENHI-PROJECT-23658100
[Presentation] Structure-activity studies of the simplified analogue of aplysiatoxin with antiproliferative activity like bryostatins2012
- Author(s)
  Kazuhiro Irie
- Organizer
  3rd International Symposium on Innovative Areas “Chemical Biology of Natural Products”
- Place of Presentation
  Kyoto Century Hotel (Kyoto)
- Year and Date
  2012-10-31
- Invited
- Data Source
  KAKENHI-PLANNED-23102011
[Presentation] Research the inhibitory activity on amyloid-β aggregation of pheolic compounds2012
- Author(s)
  Eri Kidachi, Manami Kuisu, Yusaku Miyamae, Kazuma Muakami, Kazuhiro Irie, and Hideyuki Shigemori
- Organizer
  5th AG-BIO/PERDO Graduate Conference on Agricultural Biotechnology and KU-UT Joint Seminar II
- Place of Presentation
  Kasetsart University, Thailand
- Data Source
  KAKENHI-PROJECT-24580156
[Presentation] プロテインキナーゼＣを標的とした新規抗がん剤シーズ2012
- Author(s)
  入江　一浩
- Organizer
  京都大学新技術説明会
- Place of Presentation
  JST東京別館ホール（東京、市ヶ谷）
- Year and Date
  2012-08-24
- Invited
- Data Source
  KAKENHI-PLANNED-23102011
[Presentation] カテコール系フラボノイド類によるアミロイドβ の凝集抑制機構2012
- Author(s)
  村上一馬, 佐藤瑞穂, 井久保遥子, 宇野真弓, 中川優, 片山寿美枝, 赤木謙一, 増田裕一, 竹腰清乃理, 入江一浩
- Organizer
  第54回天然有機化合物討論会
- Place of Presentation
  東京
- Year and Date
  2012-09-19
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] Monoclonal antibody against a toxic conformer of Aβ42 with a turn at E22-D232012
- Author(s)
  Irie, K., Murakami, K., Horikoshi-Sakuraba, Y., Kinoshikta, N., Shirasawa, T., Shimizu, T., Tokuda, T
- Organizer
  Alzheimer's Association International Conference (AAIC) 2012
- Place of Presentation
  Vancouver, British Columbia, Canada
- Year and Date
  2012-07-15
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] 抗がん剤開発を指向した新規PKCリガンドの創製と作用機構解析2012
- Author(s)
  入江一浩
- Organizer
  新学術領域研究「天然物ケミカルバイオロジー」第一回公開シンポジウム
- Place of Presentation
  大阪市立大学(大阪市)(招待講演)
- Year and Date
  2012-01-10
- Data Source
  KAKENHI-PLANNED-23102011
[Presentation] 天然発がんプロモーターの骨格を利用した新規抗がん剤リードの開発2012
- Author(s)
  入江一浩
- Organizer
  2012年度日本農芸化学会大会
- Place of Presentation
  京都女子大学(京都市)(招待講演)
- Year and Date
  2012-03-25
- Data Source
  KAKENHI-PLANNED-23102011
[Presentation] Development of new molecular probes and therapeutic seeds having skeletons of naturallyoccumng tumor promoters2011
- Author(s)
  Kazuhiro Irie
- Organizer
  22nd French-Japanese Symposium of Medicinal and Fine Chemistry
- Place of Presentation
  Convention Center (Rouen, France)(招待講演)
- Year and Date
  2011-09-13
- Data Source
  KAKENHI-PLANNED-23102011
[Presentation] Synthesis and structure-activity studies of the simplified analogue of aplysiatoxin with antiproliferative activity like bryostatin 12011
- Author(s)
  Kazuhiro Irie
- Organizer
  27th International Symposium on the Chemistry of Natural Products, 7th International Conference on Biodiversity
- Place of Presentation
  Convention Center (Brisbane, Australia)(招待講演)
- Year and Date
  2011-07-11
- Data Source
  KAKENHI-PLANNED-23102011
[Presentation] 天然発がんプロモーターの骨格を利用した新規ツール分子と抗がん剤シーズの開発2011
- Author(s)
  入江一浩
- Organizer
  日本農芸化学会関西支部例会(第472回講演会)
- Place of Presentation
  神戸大学(神戸市)(招待講演)
- Year and Date
  2011-12-10
- Data Source
  KAKENHI-PLANNED-23102011
[Presentation] E22Δ mutation promotes the formation of toxic conformer in Alzheimer's peptide, Aβ422011
- Author(s)
  Murakami, K., Suzuki, T., Izuo, N., Kume, T., Akaike, A., Nagata, T., Nishizaki, T., Tomiyama, T., Takuma, H., Mori, H., Irie, K
- Organizer
  27th International Symposium on the Chemistry of Natural Products, 7th International Conference on Biodiversity
- Place of Presentation
  Brisbane, Australia
- Year and Date
  2011-07-11
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] アミロイドβの毒性ターン構造を認識する抗体の開発2011
- Author(s)
  入江一浩
- Organizer
  第52回日本神経学会学術大会
- Place of Presentation
  国際会議場(名古屋市)(招待講演)
- Year and Date
  2011-05-19
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] アミロイドβ タンパクの毒性コンホメーションの同定と薬剤開発2011
- Author(s)
  入江一浩
- Organizer
  香川大学農学部第2回公開シンポジウム「生命を化学の視点から探究する」
- Place of Presentation
  香川大学農学部
- Year and Date
  2011-03-14
- Invited
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] アミロイドβ の毒性ターン構造を認識する抗体の開発2011
- Author(s)
  入江一浩
- Organizer
  第52回日本神経学会学術大会
- Place of Presentation
  名古屋
- Year and Date
  2011-05-19
- Invited
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] アミロイドβ の毒性コンホマーを標的とした立体構造特異的抗体2010
- Author(s)
  村上一馬, 堀越(櫻庭)優子, 村田央, 野田義博, 増田裕一, 木下憲明, 初田裕幸, 村山繁雄, 白澤卓二, 清水孝彦, 入江一浩
- Organizer
  2010年度日本農芸化学会大会
- Place of Presentation
  東京
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] アミロイドβタンパクの毒性コンホメーションの同定と薬剤開発2010
- Author(s)
  入江一浩
- Organizer
  香川大学農学部第2回公開シンポジウム
- Place of Presentation
  香川大学農学部(木田郡)(招待講演)
- Year and Date
  2010-03-14
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] アミロイドβ (Aβ42) の毒性コンホマー特異的抗体の作製2010
- Author(s)
  村上一馬, 堀越(櫻庭)優子, 村田央, 野田義博, 増田裕一, 木下憲明, 初田裕幸, 村山繁雄, 白澤卓二, 清水孝彦, 入江一浩
- Organizer
  第52回天然有機化合物討論会
- Place of Presentation
  静岡
- Year and Date
  2010-09-30
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] Structural analysis of toxic conformer of 42-mer amyloid β peptide using ESR spectrometry2010
- Author(s)
  Murakami, K. and Irie, K
- Organizer
  Asia-Pacific EPR/ESR symposium
- Place of Presentation
  Jeju, Republic of Korea
- Year and Date
  2010-10-12
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] Synthesis and biological profile of simple analogues of tumor-promoting aplysiatoxin as unique leads for anti-cancer drugs2010
- Author(s)
  Kazuhiro Irie
- Organizer
  2010 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010)
- Place of Presentation
  Hilton Hawaiian Village (Hawaii, USA)
- Year and Date
  2010-12-18
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] 固体NMR及びESRによるβアミロイドの立体構造と神経細胞毒性発現機構の解析2008
- Author(s)
  入江一浩
- Organizer
  理研シンポジウム「第9回分析・解析技術と化学の最先端」
- Place of Presentation
  埼玉
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-18208011
[Presentation] Verification of the intermolecular parallel β-sheet in E22K-Aβ42 (Italian) aggregates by solid-state NMR using rotational resonance2008
- Author(s)
  Kazuhiro Irie
- Organizer
  38th Annual Meeting of Society for Neuroscience
- Place of Presentation
  Washington D.C., USA
- Year and Date
  2008-11-16
- Data Source
  KAKENHI-PROJECT-18208011
[Presentation] Verification of the intermolecular parallel (β-sheet in E22K-Aβ42 (Italian) aggregates by solid-state NMR using rotational resonance2008
- Author(s)
  Kazuhiro Irie
- Organizer
  38th Annual Meeting of Society for Neuroscience
- Place of Presentation
  Washington D.C., USA
- Year and Date
  2008-11-16
- Data Source
  KAKENHI-PROJECT-18208011
[Presentation] βアミロイドの立体構造解析と神経細胞毒性発現機構2008
- Author(s)
  入江一浩
- Organizer
  第43回天然物化学談話会
- Place of Presentation
  大阪
- Year and Date
  2008-07-12
- Data Source
  KAKENHI-PROJECT-18208011
[Presentation] アルツハイマー病因ペプチドの毒性コンホメーション2008
- Author(s)
  入江一浩
- Organizer
  2008年度日本農芸化学会大会
- Place of Presentation
  名古屋
- Year and Date
  2008-03-29
- Data Source
  KAKENHI-PROJECT-18208011
[Presentation] アルツハイマー病因ペプチド(Aβ42)の毒性コンホメーション2008
- Author(s)
  入江一浩
- Organizer
  2008年度日本農芸化学会大会
- Place of Presentation
  名古屋
- Year and Date
  2008-03-29
- Data Source
  KAKENHI-PROJECT-18208011
[Presentation] βアミロイド心立体構造解析と神経細胞毒性発現機構2008
- Author(s)
  入江一浩
- Organizer
  第43回天然物化学談話会
- Place of Presentation
  大阪
- Year and Date
  2008-07-12
- Data Source
  KAKENHI-PROJECT-18208011
[Presentation] βアミロイドの毒性コンホメーシヨンのESRならびに固体NMRによる検証2008
- Author(s)
  入江一浩
- Organizer
  第27回日本認知症学会集会
- Place of Presentation
  前橋
- Year and Date
  2008-10-10
- Data Source
  KAKENHI-PROJECT-18208011
[Presentation] Verification of the intermolecular parallel beta-sheet in E22K-Abeta42 (Italian) aggregates by solid-state NMR using rotational resonance : implications for the supramolecular arrangement of the toxic conformer of Abeta422008
- Author(s)
  Kazuhiro Irie
- Organizer
  38th Annual Meeting of Society for Neuroscience
- Place of Presentation
  Washington D. C., USA
- Year and Date
  2008-11-16
- Data Source
  KAKENHI-PROJECT-18208011
[Presentation] 固体NMR及びESRによるβアミロイドの立体構造と神経細胞毒性発現機構の解析2008
- Author(s)
  入江一浩
- Organizer
  理研シンポジウム「第9回分析・解析技術と化学の最先端」
- Place of Presentation
  東京
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-18208011
[Presentation] アミロイドβタンパクの毒性コンホメーション2008
- Author(s)
  入江一浩
- Organizer
  第54回白鷺セミナー
- Place of Presentation
  大阪
- Year and Date
  2008-12-15
- Data Source
  KAKENHI-PROJECT-18208011
[Presentation] アルッハイマ-病因ペプチドの毒性コンポメ-ション2008
- Author(s)
  入江一浩
- Organizer
  2008年度日本農芸化学会大会
- Place of Presentation
  名古屋
- Year and Date
  2008-03-29
- Data Source
  KAKENHI-PROJECT-18208011
[Presentation] アミロイドβ凝集体の立体構造解析と神経細胞毒性発現機構2008
- Author(s)
  入江一浩
- Organizer
  彩都バイオヒルズクラブプロテオミクスシンポジウム
- Place of Presentation
  大阪
- Year and Date
  2008-04-28
- Data Source
  KAKENHI-PROJECT-18208011
[Presentation] アルツハイマー病因ペプチド(Aβ42)の神経細胞毒性発現機構2007
- Author(s)
  入江一浩
- Organizer
  ハイテクリサーチセンター第2回シンポジウム
- Place of Presentation
  仙台
- Year and Date
  2007-05-25
- Data Source
  KAKENHI-PROJECT-18208011
[Presentation] 固体NMRならびにESRによるアミロイドβ (Aβ42) の毒性コンホメーションの解析2007
- Author(s)
  入江一浩
- Organizer
  第49回天然有機化合物討論会
- Place of Presentation
  札幌
- Year and Date
  2007-09-19
- Data Source
  KAKENHI-PROJECT-18208011
[Presentation] 固体NMRならびにESRによるアミロイドβ(Aβ42)の毒性コンホメーションの解析2007
- Author(s)
  入江一浩
- Organizer
  第49回天然有機化合物討論会
- Place of Presentation
  札幌
- Year and Date
  2007-09-19
- Data Source
  KAKENHI-PROJECT-18208011
[Presentation] アルツハイマー病因ペプチド (Aβ42) の神経細胞毒性発現機構2007
- Author(s)
  入江一浩
- Organizer
  東北薬科大学ハイテクリサーチセンター第2回シンポジウム
- Place of Presentation
  仙台
- Year and Date
  2007-05-25
- Data Source
  KAKENHI-PROJECT-18208011
[Presentation] Toxic conformer of the 42-mer amyloid β (Aβ42)2007
- Author(s)
  Kazuhiro Irie
- Organizer
  37th Annual Meeting of Society for Neuroscience
- Place of Presentation
  San Diego, USA
- Year and Date
  2007-11-06
- Data Source
  KAKENHI-PROJECT-18208011
[Presentation] Malignant conformation of the 42-mer amyloid β peptide2006
- Author(s)
  Kazuhiro Irie
- Organizer
  2nd International Symposium on Biomolecules and Related Compounds
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2006-11-10
- Data Source
  KAKENHI-PROJECT-18208011
[Presentation] 干しいもに含まれるカフェオイルキナ酸のアルツハイマー症予防効果
- Author(s)
  繁森英幸、宮前友策、栗栖真奈美、狢川喬、村上一馬、入江一浩、韓畯奎、礒田博子
- Organizer
  第23回日本化学会関東支部茨城地区研究交流会
- Place of Presentation
  日立シビックセンター、茨城
- Data Source
  KAKENHI-PROJECT-24580156
[Presentation] Monoclonal antibody against a toxic conformer of Abeta42 with a turn at E22-D23
- Author(s)
  Kazuhiro Irie
- Organizer
  Alzheimer's Association International Conference (AAIC) 2012
- Place of Presentation
  Vancouver Convention Center (Canada)
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] Synthesis and biological activities of the simplified analogs of a natural PKC ligand aplysiatoxin
- Author(s)
  Kazuhiro Irie
- Organizer
  International Symposium on Natural Products Chemistry and Chemical Biology 2013
- Place of Presentation
  Hotel Rubura Ohzan (Nagoya)
- Invited
- Data Source
  KAKENHI-PLANNED-23102011
[Presentation] アミロイド β タンパクの毒性ターン構造の同定とその構造特異抗体の開発
- Author(s)
  入江　一浩
- Organizer
  第15回アグリバイオセミナー
- Place of Presentation
  近畿大学農学部（奈良市）
- Invited
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] 寄生植物由来化合物のアミロイドβ凝集阻害活性に関する研究
- Author(s)
  栗栖真奈美、宮前友策、木立恵利、村上一馬、Han Junkyu、礒田博子、入江一浩、繁森英幸
- Organizer
  新規素材探索研究会第11回セミナー
- Place of Presentation
  新横浜フジビューホテル、横浜
- Data Source
  KAKENHI-PROJECT-24580156
[Presentation] 日本産フサコケムシに含まれるブリオスタチン類の同定と活性評価
- Author(s)
  植野紗代、柳田亮、村上一馬、村上明、徳田春邦、鈴木信孝、藤原健史、入江一浩
- Organizer
  2012年度日本農芸化学会大会
- Place of Presentation
  京都女子大学（京都市）
- Data Source
  KAKENHI-PROJECT-23658100
[Presentation] 植物由来桂皮酸誘導体のアミロイドβ凝集阻害活性に関する研究
- Author(s)
  栗栖真奈美、宮前友策、木立恵利、村上一馬、Han Junkyu、礒田博子、入江一浩、繁森英幸
- Organizer
  第２回植物生理科学シンポジウム
- Place of Presentation
  北海道大学、札幌
- Data Source
  KAKENHI-PROJECT-24580156
[Presentation] ポリフェノールによるアミロイド β の凝集抑制機構
- Author(s)
  入江　一浩
- Organizer
  2013年度日本農芸化学会大会シンポジウム
- Place of Presentation
  東北大学川内キャンパス（仙台市）
- Invited
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] ポリフェノールによるアミロイドβの凝集阻害機構
- Author(s)
  入江　一浩
- Organizer
  第31回日本認知症学会学術集会
- Place of Presentation
  つくば国際会議場（つくば市）
- Invited
- Data Source
  KAKENHI-PROJECT-21248015

1. SHIMIZU Takahiko (40301791)

# of Collaborated Projects: 6 results

# of Collaborated Products: 51 results
2. MURAKAMI Kazuma (80571281)

# of Collaborated Projects: 4 results

# of Collaborated Products: 87 results
3. YANAGITA Ryo C. (10598121)

# of Collaborated Projects: 3 results

# of Collaborated Products: 28 results
4. TAKEGOSHI Kiyonori (10206964)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
5. SAITO Naoaki (60178499)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. UEDA Minoru (60265931)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. OHIGASHI Hajime (80026583)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
8. 松永茂樹 (60183951)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 徳田隆彦 (80242692)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
10. 喜田昭子 (70273430)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
11. SHIGEMORI Hideyuki (70202108)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
12. NAKAGAWA Yu (90452284)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. KOSHIMIZU Koichi (90026518)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. KUROKAWA Yoichi (40326088)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. KANO Kenji (10152828)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. YAMANAKA Koji (80446533)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. 高尾敏文 (10197048)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 白澤卓二 (80226323)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 川口剛司 (70195056)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 渡邉秀典 (00202416)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 品田哲郎 (30271513)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 小林資正 (40116033)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 叶直樹 (40317293)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 岡本隆一 (50451935)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 井本正哉 (60213253)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
26. 半田宏 (80107432)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 渡辺肇 (80212322)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 佐々木誠 (80235267)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 木越英夫 (90169839)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 西川俊夫 (90208158)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 石橋正己 (90212927)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 久米利明 (10303843)

# of Collaborated Projects: 1 results

# of Collaborated Products: 18 results
33. 渡邊征爾 (70633577)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 塚野千尋 (70524255)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. 掛谷秀昭 (00270596)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. 西尾和人 (10208134)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. 村田道雄 (40183652)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. 上杉志成 (10402926)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. 菊地和也 (70292951)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. 榊原康文 (10287427)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
41. BOONE CHARLES (70601342)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
42. 長田裕之 (80160836)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
43. 河岸洋和 (70183283)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
44. 遠山育夫 (20207533)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
45. NAKAJIMA Madoka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
46. TATEBE Harutsugu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
47. ABE Kentaro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
48. SATOSHI Hibino

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
49. ASAI Masashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
50. OKITA Keisuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
51. IZUMI Yasuhiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
52. FUTAMURA Akinori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
53. 小林和人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
54. 菅野秀宣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
55. 新井一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
56. 宮嶋雅一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
57. 青木茂樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
58. 旦慎吾

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
59. 増田裕一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
60. 相田美砂子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
61. 村山繁雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
62. 泉尾直孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
63. 永井宏史

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
64. 古田巧

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
65. 小林千浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
66. 戸田達史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
67. 高橋良輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
68. 渡辺大

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
69. 八幡直樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
70. 近藤隆一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
71. 丸山敬

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
72. 横手幸太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
73. 小野賢二郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
74. 赤池昭紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
75. 高田昌彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
76. 近藤孝之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

IRIE Kazuhiro 入江 一浩

Research Projects

Research Products

Co-Researchers

Very early diagnosis of Alzheimer's disease by the toxic oligomer specific antibody of amyloid betaPrincipal Investigator

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Unified comprehension of chemical communication by natural PKC ligands and development of new medicinal seedsPrincipal Investigator

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Frontiers in Chemical Communications

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Investigation on antioxidants with low pro-oxidant activity to stabilize proteins responsible for neurodegenerative disease.

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Novel Preventive Strategy for Alzheimer's Disease Based on the Toxic Conformation Theory of Amyloid betaPrincipal Investigator

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アミロイドβの毒性配座理論に基づいたアルツハイマー病の新規診断法の開発Principal Investigator

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Search for Inhibitors of Amyloid beta Aggregation from Edible Plants and Their Mechanism

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A new strategy for designing mannose receptors based on enantiomers of protein domains.

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Chemical biology using natural products

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Development and mechanistic analysis of new PKC ligands as anti-cancer agentsPrincipal Investigator

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Search for novel PKC ligands as therapeutic seeds for intractable diseasesPrincipal Investigator

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Development of medicinal seeds for Alzheimer's disease based on the structural analysis of toxic oligomers of amyloid betaPrincipal Investigator

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インドール環4位への窒素原子導入酵素の触媒機構の解析と応用Principal Investigator

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IRIE Kazuhiro 入江一浩