OKAMOTO Ryuichi 岡本隆一

Researcher Number	50451935
Other IDs	https://orcid.org/0000-0002-7047-571X
Affiliation (Current)	2020: 東京医科歯科大学, 大学院医歯学総合研究科, 教授
Affiliation (based on the past Project Information) *help	2020: 東京医科歯科大学, 大学院医歯学総合研究科, 教授 2017 – 2020: 東京医科歯科大学, 統合研究機構, 教授 2014 – 2016: 東京医科歯科大学, 再生医療研究センター, 教授 2014 – 2016: 東京医科歯科大学, 学内共同利用施設等, 教授 2012 – 2013: 東京医科歯科大学, 医歯(薬)学総合研究科, 准教授 … More
Review Section/Research Field	Principal Investigator Gastroenterology / Science and Engineering / Basic Section 53010:Gastroenterology-related / Medium-sized Section 53:Organ-based internal medicine and related fields Except Principal Investigator Gastroenterology / Science and Engineering
Keywords	Principal Investigator 炎症性腸疾患 / 粘膜再生 / Notchシグナル / 腸管上皮 / 杯細胞 / オルガノイド / 幹細胞 / 上皮幹細胞 / 細胞移植 / 腸上皮オルガノイド … More Except Principal Investigator 炎症性腸疾患 / 潰瘍性大腸炎 / 粘膜免疫 / 新規治療法 / NKT細胞 / 天然物 / ケミカルバイオロジー / 標的同定 / 天然物化学 / 天然物リガンド / 国際交流（ドイツ） / 国際交流（米国） / 国際交流（韓国） / 国際交流（スウェーデン） / 異分野融合 / 国際研究者交流（米国） / 国際研究者交流（中国） / 国際研究者交流（韓国） / 天然物ケミカルバイオロジー / 分子設計 Less

スフェロイド・デザイニングによる原腸由来臓器作成技術の開発Principal InvestigatorOngoing
- Principal Investigator
  
  岡本隆一
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Tokyo Medical and Dental University
大腸Label-retaining杯細胞の同定・機能解析と炎症粘膜再生への応用Principal InvestigatorOngoing
- Principal Investigator
  
  岡本隆一
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokyo Medical and Dental University
Analysis and therapeutic application of intestinal epithelial cell plasticity in inflammatory bowel diseasePrincipal Investigator
- Principal Investigator
  
  Okamoto Ryuichi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
Establishment of enterohormone farm by using cultured human intestinal epithelial cellsPrincipal Investigator
- Principal Investigator
  
  Okamoto Ryuichi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
Development of colitic mucosa repair therapy by the induction of regeneration-specific stem cell niche formationPrincipal Investigator
- Principal Investigator
  
  Okamoto Ryuichi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
Chemical biology using natural products
- Principal Investigator
  
  UEDA Minoru
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  Tohoku University
Development of a bio-screening method using intestinal epithelial cellsPrincipal Investigator
- Principal Investigator
  
  Okamoto Ryuichi
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  Tokyo Medical and Dental University
Analysis of intestinal mucosal repair by Notch-activated stem cellsPrincipal Investigator
- Principal Investigator
  
  OKAMOTO Ryuichi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
Novel therapeutic strategy for ulcerative colitis by targeting NKT cells
- Principal Investigator
  
  NAGAHORI Masakazu
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
Analysis of Notch-mediated regeneration of the intestinal epitheliaPrincipal Investigator
- Principal Investigator
  
  OKAMOTO Ryuichi
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
Development of mucosa-regenerating therapy through comprehensive analysis of intestine-specific Notch target genesPrincipal Investigator
- Principal Investigator
  
  OKAMOTO Ryuichi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University

All 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation Book

[Book] PD-3確定診断困難な多発小腸潰瘍の1例栄養-評価と治療2012
- Author(s)
  森尾純子,荒木昭博,岡田英理子,鈴木伸治,土屋輝一郎,藤井俊光,長沼誠,長堀正和,江頭徹哉,齊藤詠子,福島啓太,河合富貴子,藤木純子,櫻井幸,根本泰宏,中川美奈,岡本隆一,東正新,柿沼晴,永石宇司,中村哲也,坂本直哉,渡辺守,河内洋,江石義信
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-23790777
[Book] 腫瘍をめぐるQ&A(Question45)Lgr5とは?2012
- Author(s)
  伊藤剛、岡本隆一、清水寛路、村野竜朗、水谷知裕、油井史郎、土屋輝一郎、中村哲也、渡辺守
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-23790777
[Book] Microscopic Colitis(顕微鏡的腸炎)2012
- Author(s)
  岡本隆一、渡辺守
- Publisher
  Modern Physician
- Data Source
  KAKENHI-PROJECT-23790777
[Book] 上皮細胞再生による腸炎治療戦略2011
- Author(s)
  中村哲也、岡本隆一、渡辺守
- Publisher
  ニューサイエンス社
- Data Source
  KAKENHI-PROJECT-23790777
[Book] 炎症性腸疾患の診断と治療をめぐる新展開2011
- Author(s)
  岡本隆一、渡辺守
- Publisher
  メジカルビュー社
- Data Source
  KAKENHI-PROJECT-23790777
[Book] 炎症と組織再生.FunctionalFood2011
- Author(s)
  岡本隆一、渡辺守
- Publisher
  フジメディカル
- Data Source
  KAKENHI-PROJECT-23790777
[Journal Article] Ubiquitin D is up-regulated by synergy of Notch signaling and TNF-α in the inflamed intestinal epithelia of IBD patients.2019
- Author(s)
  Kawamoto Ami、Nagata Sayaka、Anzai Sho、Takahashi Junichi、Kawai Mao、Hama Minami、Nogawa Daichi、Yamamoto Kouhei、Kuno Reiko、Suzuki Kohei、Shimizu Hiromichi、Hiraguri Yui、Yui Shiro、Oshima Shigeru、Tsuchiya Kiichiro、Nakamura Tetsuya、Ohtsuka Kazuo、Kitagawa Masanobu、Okamoto Ryuichi、Watanabe Mamoru
- Journal Title
  
  Journal of Crohn and Colitis
  
  Volume: 13 Pages: 495-509
- DOI
  10.1093/ecco-jcc/jjy180
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09370, KAKENHI-PROJECT-18K07902, KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-17K19675, KAKENHI-PROJECT-18K19535, KAKENHI-PROJECT-18K15743, KAKENHI-PROJECT-18K15774, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-16H05284, KAKENHI-PROJECT-17H04024, KAKENHI-PROJECT-18H02791, KAKENHI-PROJECT-18H02867, KAKENHI-PROJECT-17K19513, KAKENHI-PROJECT-17K19674
[Journal Article] Novel polyubiquitin imaging system, PolyUb-FC, reveals that K33-linked polyubiquitin is recruited by SQSTM1/p62.2018
- Author(s)
  Yoichi Nibe, Shigeru Oshima, Masanori Kobayashi, Chiaki Maeyashiki, Yu Matsuzawa, Kana Otsubo, Hiroki Matsuda, Emi Aonuma, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Shinichiro Nakada, Mamoru Watanabe
- Journal Title
  
  Autophagy
  
  Volume: 22 Pages: 347-358
- DOI
  10.1080/15548627.2017.1407889
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09372, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H05284, KAKENHI-PROJECT-16H05286, KAKENHI-PROJECT-16K15423, KAKENHI-PROJECT-17K19675, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-17H04024, KAKENHI-PROJECT-17K19513, KAKENHI-PROJECT-26241014
[Journal Article] Contribution of ATOH1+ cells to the homeostasis, repair and tumorigenesis of the colonic epithelium.2018
- Author(s)
  Ishibashi Fumiaki、Shimizu Hiromichi、Nakata Toru、Fujii Satoru、Suzuki Kohei、Kawamoto Ami、Anzai Sho、Kuno Reiko、Nagata Sayaka、Ito Go、Murano Tatsuro、Mizutani Tomohiro、Oshima Shigeru、Tsuchiya Kiichiro、Nakamura Tetsuya、Watanabe Mamoru、Okamoto Ryuichi
- Journal Title
  
  Stem Cell Rep.
  
  Volume: 10 Pages: 27-42
- DOI
  10.1016/j.stemcr.2017.11.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19674, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H05284, KAKENHI-PROJECT-17K19675, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-17H04024, KAKENHI-PROJECT-17K19513
[Journal Article] Single cell analysis of Crohn’s disease patient-derived small intestinal organoids reveals disease activity-dependent modification of stem cell properties.2018
- Author(s)
  Suzuki Kohei、Murano Tatsuro、Shimizu Hiromichi、Ito Go、Nakata Toru、Fujii Satoru、Ishibashi Fumiaki、Kawamoto Ami、Anzai Sho、Kuno Reiko、Kuwabara Konomi、Takahashi Junichi、Tsuchiya Kiichiro、Nakamura Tetsuya、Ohtsuka Kazuo、Watanabe Mamoru、Okamoto Ryuichi
- Journal Title
  
  J Gastroenterol.
  
  Volume: 印刷中 Pages: 1035-1047
- DOI
  10.1007/s00535-018-1437-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H05284, KAKENHI-PROJECT-16K09302, KAKENHI-PROJECT-17K09370, KAKENHI-PROJECT-18K07902, KAKENHI-PROJECT-17K19675, KAKENHI-PROJECT-18K19535, KAKENHI-PROJECT-18K15743, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-17H04024, KAKENHI-PROJECT-18H02791, KAKENHI-PROJECT-18H02867, KAKENHI-PROJECT-17K19513, KAKENHI-PROJECT-17K19674
[Journal Article] Indispensable role of Notch ligand-dependent signaling in the proliferation and stem cell niche maintenance of APC-deficient intestinal tumors.2017
- Author(s)
  Nakata T, Shimizu H, Nagata S, Ito G, Fujii S, Suzuki K, Kawamoto A, Ishibashi F, Kuno R, Anzai S, Murano T, Mizutani T, Oshima S, Tsuchiya K, Nakamura T, Hozumi K, Watanabe M, Okamoto R
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 482 Pages: 1296-1303
- DOI
  10.1016/j.bbrc.2016.12.031
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H05284
[Journal Article] New Notch inhibitors from Calotropis gigantea that induce neuronal differentiation of neural stem cells2017
- Author(s)
  Yoneyama Tatsuro、Arai Midori A.、Akamine Ryuta、Koryudzu Kazune、Tsuchiya Anna、Sadhu Samir K.、Ahmed Firoj、Itoh Motoyuki、Okamoto Ryuichi、Ishibashi Masami
- Journal Title
  
  J. Nat. Prod.
  
  Volume: 80 Pages: 2453-2461
- DOI
  10.1021/acs.jnatprod.7b00282
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26305001, KAKENHI-PROJECT-15H04650, KAKENHI-PROJECT-16H05284, KAKENHI-PROJECT-17H03992
[Journal Article] Data showing proliferation and differentiation of intestinal epithelial cells under targeted depletion of Notch ligands in mouse intestine.2017
- Author(s)
  Nakata T, Shimizu H, Nagata S, Ito G, Fujii S, Suzuki K, Kawamoto A, Ishibashi F, Kuno R, Anzai S, Murano T, Mizutani T, Oshima S, Tsuchiya K, Nakamura T, Hozumi K, Watanabe M, Okamoto R
- Journal Title
  
  Data in Brief
  
  Volume: 10 Pages: 551-556
- DOI
  10.1016/j.dib.2016.12.045
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H05284
[Journal Article] Role of epithelial cells in the pathogenesis and treatment of inflammatory bowel disease.2016
- Author(s)
  Ryuichi Okamoto, Mamoru Watanabe
- Journal Title
  
  J. Gastroenterol
  
  Volume: 51 Pages: 11-21
- DOI
  10.1007/s00535-015-1098-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K15286, KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-25293170
[Journal Article] Reduced human α-defensin 6 in non-inflamed jejunal tissue of Crohn’s disease patients2016
- Author(s)
  Hayashi R , Tsuchiya K, Okamoto R, Watanabe M.et al.
- Journal Title
  
  Inflammatory Bowel Diseases
  
  Volume: 22 Pages: 1119-1128
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23102003
[Journal Article] Matrix metalloproteinase-14 mediates formation of bile ducts and hepatic maturation of fetal hepatic progenitor cells.2016
- Author(s)
  Otani S, Kakinuma S, Kamiya A, Goto F, Kaneko S, Miyoshi M, Tsunoda T, Asano Y, Kawai-Kitahata F, Nitta S, Nakata T, Okamoto R, Itsui Y, Nakagawa M, Azuma S, Asahina Y, Yamaguchi T, Koshikawa N, Seiki M, Nakauchi H, Watanabe M.
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 469 Pages: 1062-1068
- DOI
  10.1016/j.bbrc.2015.12.105
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08988, KAKENHI-PROJECT-26460358, KAKENHI-PROJECT-26460987, KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-25293169, KAKENHI-PROJECT-25293170, KAKENHI-PROJECT-15K08989, KAKENHI-PROJECT-16H05285, KAKENHI-PROJECT-15K15285
[Journal Article] Reduced Human ホア-defensin 6 in Noninflamed Jejunal Tissue of Patients with Crohn's Disease.2016
- Author(s)
  Hayashi R , Tsuchiya K, Okamoto R,Watanabe M,et al
- Journal Title
  
  Inflamm Bowel Dis.
  
  Volume: 22 Pages: 1119-1128
- DOI
  10.1097/mib.0000000000000707
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K15286, KAKENHI-PROJECT-15K15287, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-25460945, KAKENHI-PROJECT-25461031, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-16K09302
[Journal Article] PGE2 is a direct and robust mediator of anion/fluid secretion by human intestinal epithelial cells2016
- Author(s)
  Fujii S, Okamoto R, Suzuki K, Kawamoto A, Ishibashi F, Nakata T, Murano T, Ito G, Shimizu H, Mizutani T, Oshima S, Tsuchiya K, Nakamura T, Araki A, Ohtsuka K, Watanabe M
- Journal Title
  
  Sci Rep
  
  Volume: 6 Pages: 36795-36795
- DOI
  10.1038/srep36795
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-15K15286, KAKENHI-PROJECT-16K09302
[Journal Article] TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy.2015
- Author(s)
  Matsuzawa Y, Oshima S, Takahara M, Maeyashiki C, Nemoto Y, Kobayashi M, Nibe Y, Nozaki K, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Averil Ma, Watanabe M
- Journal Title
  
  Autophagy
  
  Volume: 11 Pages: 1052-1062
- DOI
  10.1080/15548627.2015.1055439
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460963, KAKENHI-PROJECT-15K15286, KAKENHI-PROJECT-15K15288, KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-25460946, KAKENHI-PROJECT-25293170
[Journal Article] Perspectives for Regenerative Medicine in the Treatment of Inflammatory Bowel Diseases.2015
- Author(s)
  Ryuichi Okamoto, Mamoru Watanabe
- Journal Title
  
  Digestion
  
  Volume: 92 Pages: 73-77
- DOI
  10.1159/000438663
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K15286, KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-25293170
[Journal Article] Reduced human α-defensin 6 in non-inflamed jejunal tissue of Crohn’s disease patients2015
- Author(s)
  Hayashi R , Tsuchiya K, Okamoto R, Watanabe M.et al.
- Journal Title
  
  Inflammatory Bowel Diseases
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293170
[Journal Article] Atonal homolog 1 protein stabilized by tumor necrosis factor α induces high malignant potential in colon cancer cell line.2015
- Author(s)
  Keita Fukushima, Kiichiro Tsuchiya,Okamoto Ryuichi, Mamoru Watanabe,et al
- Journal Title
  
  Cancer Sci.
  
  Volume: 106 Pages: 1000-1007
- DOI
  10.1111/cas.12703
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K15286, KAKENHI-PROJECT-15K15287, KAKENHI-PROJECT-15K15288, KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-25293170
[Journal Article] RIPK3 regulates p62- LC3 complex formation via the caspase-8-dependent cleavage of p622015
- Author(s)
  Y. Matsuzawa , S. Oshima, Y. Nibe, M.Kobayashi, C. Maeyashiki, Y. Nemoto, T. Nagaishi, R. Okamoto R, K. Tsuchiya, T. Nakamura, M. Watanabe.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 456(1) Pages: 298-304
- DOI
  10.1016/j.bbrc.2014.11.075
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-24590935, KAKENHI-PROJECT-24590936, KAKENHI-PROJECT-24590937, KAKENHI-PUBLICLY-25114703, KAKENHI-PUBLICLY-25130704, KAKENHI-PROJECT-25293170, KAKENHI-PROJECT-25460946, KAKENHI-PROJECT-26460963, KAKENHI-PROJECT-26221307
[Journal Article] Fluorescent labelling of intestinal epithelial cells reveals independent long-lived intestinal stem cells in a crypt.2014
- Author(s)
  N. Horita, K. Tsuchiya, R. Hayashi, K. Fukushima, S. Hibiya, M. Fukuda, Y. Kano, T. Mizutani, Y. Nemoto, S. Yui, R. Okamoto, T. Nakamura, M. Watanabe
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 454 Pages: 493-499
- DOI
  10.1016/j.bbrc.2014.10.091
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-24590935, KAKENHI-PUBLICLY-25114703, KAKENHI-PUBLICLY-25130704, KAKENHI-PROJECT-25293170, KAKENHI-PROJECT-25670367, KAKENHI-PROJECT-25860524, KAKENHI-PROJECT-26221307
[Journal Article] Distinct expression patterns of Notch ligands, Dll1 and Dll4, in normal and inflamed mice intestine.2014
- Author(s)
  Shimizu H, Okamoto R, Ito G, Nakata T, Suzuki K, Murano T, Mizutani T, Tsuchiya K, Nakamura T, Hozumi K, Watanabe M.
- Journal Title
  
  2014
  
  Volume: 2
- DOI
  10.7717/peerj.370
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-24590935, KAKENHI-PUBLICLY-25114703, KAKENHI-PUBLICLY-25130704, KAKENHI-PROJECT-25293170, KAKENHI-PROJECT-25860524
[Journal Article] Myosin light chain kinase expression induced via tumor necrosis factor receptor 2 signaling in the epithelial cells regulates the development of colitis-associated carcinogenesis2014
- Author(s)
  Suzuki M, Nagaishi T, Yamazaki M, Onizawa M, Watabe T, Sakamaki Y, Ichinose S, Totsuka M, Oshima S, Okamoto R, Shimonaka M, Yagita H, Nakamura T, Watanabe M.
- Journal Title
  
  PLoS One.
  
  Volume: 9
- DOI
  10.1371/journal.pone.0088369
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-24590936, KAKENHI-PROJECT-24590937, KAKENHI-PROJECT-25293170, KAKENHI-PROJECT-25670367, KAKENHI-PROJECT-25670708, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-26460963
[Journal Article] The acquisition of malignant potential in colon cancer is regulated by the stabilization of Atonal homolog 1 protein2013
- Author(s)
  Kano Y
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 432 Pages: 175-181
- DOI
  10.1016/j.bbrc.2013.01.034
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-22130001, KAKENHI-PLANNED-22130009, KAKENHI-PROJECT-22229005, KAKENHI-PROJECT-23390062, KAKENHI-PROJECT-23659394, KAKENHI-PROJECT-23790357, KAKENHI-PROJECT-23790777, KAKENHI-PROJECT-24590935, KAKENHI-PLANNED-23102003, KAKENHI-PUBLICLY-23130506
[Journal Article] Lineage-specific expression of bestrophin-2 and bestrophin-4 in human intestinal epithelial cells2013
- Author(s)
  Ito G, Okamoto R, Nakamura T, Watanabe M et al
- Journal Title
  
  PLoS One.
  
  Volume: 8
- DOI
  10.1371/journal.pone.0079693
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229005, KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-24590935, KAKENHI-PROJECT-24590936, KAKENHI-PUBLICLY-25114703, KAKENHI-PUBLICLY-25130704, KAKENHI-PROJECT-25293170, KAKENHI-PROJECT-25460945, KAKENHI-PROJECT-25461031, KAKENHI-PROJECT-25670367, KAKENHI-PROJECT-25860524
[Journal Article] Th1/Th17-mediated interstitial pneumonia in chronic colitis mice independent of intestinal microbiota2013
- Author(s)
  Nemoto Y, Watanabe M et al
- Journal Title
  
  J Immunol
  
  Volume: 190 Pages: 6616-25
- DOI
  10.4049/jimmunol.1202930
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229005, KAKENHI-PROJECT-23590934, KAKENHI-PROJECT-24590935, KAKENHI-PROJECT-24590936, KAKENHI-PROJECT-24659375, KAKENHI-PUBLICLY-25114703, KAKENHI-PUBLICLY-25130704, KAKENHI-PROJECT-25293170, KAKENHI-PROJECT-25670367
[Journal Article] IL-7 promotes long-term in vitro survival of unique long-lived memory subset generated from mucosal effector memory CD4+ T cells in chronic colitis mice2013
- Author(s)
  Takahara M, Nemoto Y, Oshima S, Matsuzawa Y, Kanai T, Okamoto R, Tsuchiya K, Nakamura T, Yamamoto K, Watanabe M.
- Journal Title
  
  Immunol Lett
  
  Volume: 156 Pages: 82-93
- DOI
  10.1016/j.imlet.2013.09.001
- NAID
  120005468269
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-24590935, KAKENHI-PROJECT-24590936, KAKENHI-PUBLICLY-25114703, KAKENHI-PUBLICLY-25130704, KAKENHI-PROJECT-25293170
[Journal Article] Bone marrow-mesenchymal stem cells are a major source of interleukin-7 and sustain colitis by forming the niche for colitogenic CD4 memory T cells2013
- Author(s)
  Nemoto Y, Nakamura T, Watanabe M et al
- Journal Title
  
  Gut
  
  Volume: 62 Pages: 1142-1152
- DOI
  10.1136/gutjnl-2012-302029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229005, KAKENHI-PROJECT-23590934, KAKENHI-PROJECT-23659394, KAKENHI-PROJECT-23790777, KAKENHI-PROJECT-24590933, KAKENHI-PROJECT-24590935, KAKENHI-PROJECT-24590936, KAKENHI-PROJECT-24659375, KAKENHI-PROJECT-25293170, KAKENHI-PROJECT-25670367, KAKENHI-PLANNED-23102003, KAKENHI-PUBLICLY-23130506
[Journal Article] The early retinal progenitor-expressed gene Sox11 regulates the timing of the differentiation of retinal cells.2013
- Author(s)
  Kakinuma S, Kiyohashi K, Kamiya A, Sakamoto N, Nitta S, Yamanaka H, YoshinoK, Fujiki J, Murakawa M, Kusano-Kitazume A, Shimizu H, Okamoto R, Azuma S, Nakagawa M, Asahina Y, Tanimizu N, Kikuchi A, Nakauchi H, and *WatanabeM
- Journal Title
  
  Development
  
  Volume: (in press) Pages: 2502-13
- DOI
  10.1002/hep.26293
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-21590831, KAKENHI-ORGANIZER-23112001, KAKENHI-PLANNED-23112004, KAKENHI-PROJECT-23689040, KAKENHI-PROJECT-23790777, KAKENHI-PUBLICLY-24112505, KAKENHI-PUBLICLY-24112519, KAKENHI-PROJECT-24390304, KAKENHI-PROJECT-24590957, KAKENHI-PROJECT-24590958, KAKENHI-PROJECT-24590959, KAKENHI-PROJECT-24590960, KAKENHI-PROJECT-24659359, KAKENHI-PROJECT-25250018, KAKENHI-PROJECT-25293169, KAKENHI-PROJECT-25293289, KAKENHI-PROJECT-25460271, KAKENHI-PROJECT-25670366, KAKENHI-PROJECT-25860522, KAKENHI-PLANNED-23102003, KAKENHI-PLANNED-23106004
[Journal Article] Real-time analysis of P- gly coprotei n- mediated drug transport across primary intestinal epithelium three-dimensionally cultured in vitro2012
- Author(s)
  Mizutani T, Nakamura T, et al
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 419 Pages: 238-243
- DOI
  10.1016/j.bbrc.2012.01.155
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590803, KAKENHI-PROJECT-21590805, KAKENHI-PUBLICLY-22117508, KAKENHI-PROJECT-22229005, KAKENHI-PROJECT-22590694, KAKENHI-PROJECT-22590695, KAKENHI-PROJECT-22590696, KAKENHI-PLANNED-23102003, KAKENHI-PUBLICLY-23130506, KAKENHI-PROJECT-23590934, KAKENHI-PROJECT-23659394, KAKENHI-PROJECT-23790777, KAKENHI-PROJECT-24390186, KAKENHI-PROJECT-24590936, KAKENHI-PROJECT-24590937, KAKENHI-PUBLICLY-24112508
[Journal Article] Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+stem cell2012
- Author(s)
  Yui S, Nakamura T, Nagaishi T, Okamoto R, Watanabe M, et al
- Journal Title
  
  Nat Med
  
  Volume: 18 Pages: 618-623
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590806
[Journal Article] The development of colitogenic CD4+ T cells is regulated by IL-7 in collaboration with NK cell function in a murine model of colitis.2012
- Author(s)
  Yamaji O, Totsuka T
- Journal Title
  
  J. Immunol
  
  Volume: 188 Pages: 2524-2536
- DOI
  10.4049/jimmunol.1100371
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590804, KAKENHI-PROJECT-21590805, KAKENHI-PROJECT-21590806, KAKENHI-PUBLICLY-22117508, KAKENHI-PROJECT-22229005, KAKENHI-PROJECT-22590694, KAKENHI-PROJECT-22590695, KAKENHI-PROJECT-22590696, KAKENHI-PUBLICLY-23130506, KAKENHI-PROJECT-23390112, KAKENHI-PROJECT-23590934, KAKENHI-PROJECT-23659223, KAKENHI-PROJECT-23659394, KAKENHI-PROJECT-23790777, KAKENHI-PROJECT-24590936, KAKENHI-PROJECT-24590937, KAKENHI-PLANNED-23102003
[Journal Article] Luminal CD4+ T cells penetrate gut epithelial monolayers and egress from lamina propria to blood circulation.2012
- Author(s)
  Nemoto Y, Watanabe M
- Journal Title
  
  Gastroenterology.
  
  Volume: 141 Pages: 2030-2039
- DOI
  10.1053/j.gastro.2011.08.035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590804, KAKENHI-PROJECT-21590805, KAKENHI-PUBLICLY-22117508, KAKENHI-PROJECT-22229005, KAKENHI-PROJECT-22590694, KAKENHI-PROJECT-22590695, KAKENHI-PUBLICLY-23130506, KAKENHI-PROJECT-23659394, KAKENHI-PROJECT-23790777
[Journal Article] The development of colitogenic CD4+T cells is regulated by IL-7 in collaboration with natural killer cell function in a murine model of colitis2012
- Author(s)
  Nagaishi T, Yamaji O, Okamoto R, Watanabe M, et al
- Journal Title
  
  J Immunol
  
  Volume: 188 Pages: 2524-2536
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590806
[Journal Article] Suppression ofhath1 gene expression directly regulated by hes1 via notch signaling is associated with goblet cell depletion in ulcerative colitis.2012
- Author(s)
  Zheng X, Nakamura T, et al
- Journal Title
  
  Inflamm Bowel Di
  
  Volume: 17 Pages: 2251-2260
- DOI
  10.1002/ibd.21611
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590805, KAKENHI-PUBLICLY-22117508, KAKENHI-PROJECT-22229005, KAKENHI-PROJECT-22590694, KAKENHI-PROJECT-22590695, KAKENHI-PUBLICLY-23130506, KAKENHI-PROJECT-23790777, KAKENHI-PROJECT-24659359
[Journal Article] Endoscopic ultrasound with double-balloon endoscopy for the diagnosis of inverted Meckel's diverticulum: a case report2012
- Author(s)
  Araki A, Tsuchiya K, Oshima S, Okada E,Suzuki S, Akiyama JM, Fujii T, OkamotoR, Watanabe M
- Journal Title
  
  J Med Case Rep.
  
  Volume: 6(1) Pages: 328-328
- DOI
  10.1186/1752-1947-6-328
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590694, KAKENHI-PROJECT-22590695, KAKENHI-PROJECT-23590934, KAKENHI-PROJECT-23790776, KAKENHI-PROJECT-23790777, KAKENHI-PROJECT-24590935, KAKENHI-PLANNED-23102003, KAKENHI-PUBLICLY-23130506
[Journal Article] Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5(+) stem cell.2012
- Author(s)
  Yui S, Nakamura T, Sato T, Nemoto Y, Mizutani T, Zheng X, Ichinose S, Nagaishi T, Okamoto R, Tsuchiya K, Clevers H, and Watanabe M
- Journal Title
  
  Nat. Med.
  
  Volume: 18 Pages: 618-23
- DOI
  10.1038/nm.2695
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590803, KAKENHI-PROJECT-21590805, KAKENHI-PROJECT-21590806, KAKENHI-PUBLICLY-22117508, KAKENHI-PROJECT-22229005, KAKENHI-PROJECT-22590694, KAKENHI-PROJECT-22590695, KAKENHI-PROJECT-22590696, KAKENHI-PLANNED-23102003, KAKENHI-PUBLICLY-23130506, KAKENHI-PROJECT-23590934, KAKENHI-PROJECT-23659394, KAKENHI-PROJECT-23790777, KAKENHI-PROJECT-23890204, KAKENHI-PROJECT-24390186, KAKENHI-PROJECT-24590936, KAKENHI-PROJECT-24590937, KAKENHI-PROJECT-24689036, KAKENHI-PROJECT-24790684, KAKENHI-PUBLICLY-24112508, KAKENHI-PUBLICLY-24112523
[Journal Article] Real-time analysis of P-glycoprotein-mediated drug transport across primary intestinal epithelium three-dimensionally cultured in vitro2012
- Author(s)
  Mizutani T, Nakamura T, Nagaishi T, Okamoto R, Watanabe M, et al
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 419 Pages: 238-243
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590806
[Journal Article] Suppression of hath1 gene expression directly regulated by hes1 via notch signaling is associated with goblet cell depletion in ulcerative colitis.2011
- Author(s)
  Zheng X, Tsuchiya K, Okamoto R, Watanabe M.(他4名、3番目)
- Journal Title
  
  Inflamm Bowel Dis.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790651
[Journal Article] Longitudinal cell formation in the entire human small intestine is correlated with the localization of Hath1 and Klf4.2011
- Author(s)
  Iwasaki M, Tsuchiya K, Suzuki S, Watanabe M, et al
- Journal Title
  
  J Gastroenterol.
  
  Volume: 46 Pages: 191-202
- DOI
  10.1007/s00535-010-0346-x
- NAID
  10029027237
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590805, KAKENHI-PROJECT-22590694, KAKENHI-PROJECT-22590695, KAKENHI-PUBLICLY-23130506, KAKENHI-PROJECT-23790777
[Journal Article] Upregulated IL-7 receptor (alpha) expression on colitogenic memory CD4+ T cells may participate in the development and persistence of chronic colitis.2011
- Author(s)
  Shinohara T, Okamoto R, Nakamura T, Watanabe M (他6名、5番目)
- Journal Title
  
  J Immunol. 186
  
  Pages: 2623-2632
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790651
[Journal Article] Suppression of hath1 gene expression directly regulated by hes1 via notch signaling is associated with goblet cell depletion in ulcerative colitis.2011
- Author(s)
  Zheng X, Okamoto R., et al
- Journal Title
  
  Inflamm Bowel Dis
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790651
[Journal Article] Longitudinal cell formation in theentire human small intestine is correlated with the localization of Hath1 and Klf4.2010
- Author(s)
  Iwasaki M, Okamoto R, Nakamura T, Watanabe M (他11名、3番目)
- Journal Title
  
  J Gastroenterol. 46
  
  Pages: 191-202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790651
[Journal Article] Prevalence of metabolic syndrome is comparable between inflammatory bowel disease patients and the general population.2010
- Author(s)
  Nagahori M, Hyun SB, Totsuka T, Okamoto R, Kuwahara E, TaWatkebayashi T, Naganuma M, Watanaabe M
- Journal Title
  
  J G astroenterol
  
  Volume: 45 Pages: 1008-1013
- NAID
  10027699223
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590806
[Journal Article] Longitudinal cell formation in the entire human small intestine is correlated with the localization of Hath1 and Klf42010
- Author(s)
  Iwasaki M, Okamoto R., et al
- Journal Title
  
  J Gastroenterol
  
  Volume: 46 Pages: 191-202
- NAID
  10029027237
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790651
[Journal Article] IL-2 is positively involved in the development of colitogenic CD4+ IL-7R alpha high memory T cells in chronic colitis.2010
- Author(s)
  Kameyama K, Okamoto R, Nakamura T, Watanabe M (他7名、5番目)
- Journal Title
  
  Eur JImmunol. 40
  
  Pages: 423-436
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790651
[Journal Article] Delta-like 1 expression promotes goblet cell differentiation in Notch-inactivated human colonic epithelial cells2010
- Author(s)
  Akiyama J, Okamoto R, et al
- Journal Title
  
  Biochem Biophys Res Commun 393
  
  Pages: 662-667
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790651
[Journal Article] Delta-like1 expression promotes goblet cell differentiation in Notch-inactivated human colonic epithelial cells.2010
- Author(s)
  Akiyama J, Okamoto R, Nakamura T, Watanabe M (他4名、2番目)
- Journal Title
  
  Biochem. Biophys. Res. Commun. 393
  
  Pages: 662-667
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790651
[Journal Article] Signaling pathway via TNF-alpha/NF-kappaB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis.2009
- Author(s)
  Onizawa M, Okamoto R, Nakamura T, Watanabe M(他12名、9番目)
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol. 296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790651
[Journal Article] Requirement of Notch activation during regeneration of the intestinal epithelia2009
- Author(s)
  Okamoto R, Tsuchiya K, et.al.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol 296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] Long-lived colitogenic CD4+ memory T cells residing outside the intestine participate in the perpetuation of chronic colitis.2009
- Author(s)
  Nemoto Y, Okamoto R, Nakamura T, Watanabe M.(他8名、7番目)
- Journal Title
  
  J. Immunol. 183(8)
  
  Pages: 5059-5068
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790651
[Journal Article] Musashi-1 suppresses expression of Paneth cell-specific genes in human intestinal epithelial cells.2009
- Author(s)
  Murayama M, Okamoto R, Nakamura T, Watanabe M(他4名、2番目)
- Journal Title
  
  J Gastroenterol. 44
  
  Pages: 173-182
- NAID
  10025173646
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790651
[Journal Article] Long-lived colitogenic CD4+ memory T cells residing outside the intestine participate in the perpetuation of chronic colitis2009
- Author(s)
  Nemoto Y, Okamoto R, et al
- Journal Title
  
  J Immunol 183
  
  Pages: 5059-5068
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790651
[Journal Article] Musashi-1 suppresses expression of Paneth cell-specific genes in human intestinal epithelial cells.2009
- Author(s)
  Murayama M, Okamoto R, et al
- Journal Title
  
  J Gastroenterol. 44
  
  Pages: 173-182
- NAID
  10025173646
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] Musashi-1 suppresses expression of Paneth cell specific genes in human intestinal epithelial cells2009
- Author(s)
  Murayama M, Okamoto R, Tsuchiya K, Akiyama J, Nakamura T, Sakamoto N, Kanai T, Watanabe M
- Journal Title
  
  J Gastroenterol 44(3)
  
  Pages: 173-182
- NAID
  10025173646
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] Requirement of Notch activation during regeneration of the intestinal epithelia.2009
- Author(s)
  Okamoto R, Nakamura T, Watanabe M (他4名、1番目)
- Journal Title
  
  Am.J.Physiol.Gastrointest.Liver Physiol. 296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790651
[Journal Article] Requirement of Notch activation during regeneration of the intestinal epithelia.2009
- Author(s)
  Okamoto R, Tsuchiya K, et al.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol. 296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] Signaling pathway via TNF/NF B in intestinal epithelial cell smay be directly involved in colitis associatedcarcinogenesis2009
- Author(s)
  Nagaishi T, Onizawa M Okamoto R, Watanabe M, et al
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol
  
  Volume: 296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590806
[Journal Article] RANK-RANKL signaling pathway is critically in volvedin the function of CD4+CD25+ regulatory T cells in chronic colitis.2009
- Author(s)
  Totsuka T, Okamoto R, Nakamura T, Watanabe M(他8名、5番目)
- Journal Title
  
  J. Immunol. 182
  
  Pages: 6079-6087
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790651
[Journal Article] IL-7 is essential for lymphopenia-driven turnover of colitogenic CD4(+) memory T cells in chronic colitis.2009
- Author(s)
  Tomita T, Okamoto R, Watanabe M.(他7名)
- Journal Title
  
  Eur J Immunol. 39
  
  Pages: 2737-2747
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790651
[Journal Article] Systemic, but not intestinal, IL-7 is essential for the persistence of chronic colitis2008
- Author(s)
  Tomita T, Kanai T, Nemoto Y, TotsukaT, Okamoto R, Tsuchiya K, SakamotoN, Watanabe M
- Journal Title
  
  J Immunol 180(1)
  
  Pages: 383-90
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] MyD88-dependent pathway in T cellsdirectly modulates the expansionof colitogenic CD4+ T cells inchronic colitis2008
- Author(s)
  Tomita T, Kanai T, Fujii T, NemotoY, Okamoto R, Tsuchiya K, TotsukaT, Sakamoto N, Akira S, Watanabe M
- Journal Title
  
  J Immunol 180(8)
  
  Pages: 5291-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] Negative feedback regulation of colitogenic CD4(+)T cells by increased granulopoiesis2008
- Author(s)
  Nemoto Y, Kanai T, Tohda S, TotsukaT, Okamoto R, Tsuchiya K, Nakamura T, Sakamoto N, Fukuda T, Miura O, Yagita H, Watanabe M
- Journal Title
  
  Inflamm Bowel Dis 14(11)
  
  Pages: 1491-503
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] Inducible expression of microRNA-194 is regulated by HNF-1 alpha during intestinal epithelial cell differentiation.2008
- Author(s)
  Hino K, Tsuchiya K, Fukao T, Kiga K, Okamoto R, et al.
- Journal Title
  
  RNA. 14
  
  Pages: 1433-1442
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] Systemic, but not intestinal, IL-7 is essential for the persistence of chronic colitis.2008
- Author(s)
  Tomita T, Kanai T, Nemoto Y, Totsuka T, Okamoto R, et. al.
- Journal Title
  
  Journal of Immunology 180
  
  Pages: 383-390
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] Flagellin stimulation suppresses IL-7 secretion of intestinal epithelial cells2008
- Author(s)
  Yoshioka A, Okamoto R, Oshima S, Akiyama J, Tsuchiya K, Nakamura T, Kanai T, Watanabe M
- Journal Title
  
  Cytokine 44(1)
  
  Pages: 57-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] Proteasomal degradation of Atoh1 by aberrant Wnt signaling maintains the undifferentiated state of colon cancer2008
- Author(s)
  Aragaki M, Tsuchiya K, Okamoto R, Yoshioka S, Nakamura T, Sakamoto N, Kanai T, Watanabe M
- Journal Title
  
  Biochem Biophys Res Commun 368(4)
  
  Pages: 923-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] Inducible expression of microRNA-194 is regulated by HNF-1alpha during intestinal epithelial cell differentiation2008
- Author(s)
  Hino K, Tsuchiya K, Fukao T, Kiga K, Okamoto R, Kanai T, Watanabe M
- Journal Title
  
  RNA 14(7)
  
  Pages: 1433-42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] Inducible expression of microRNA-194 is regulated by HNF-1 during intestinal epithelial cell differentiation.2008
- Author(s)
  Hino K, Tsuchiya K, Fukao T, Kiga K, Okamoto R, et. al.
- Journal Title
  
  RNA (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] Immunosenescent colitogenic CD4(+)T cells convert to regulatory cells and suppress colitis2008
- Author(s)
  Totsuka T, Kanai T, Nemoto Y, TomitaT, Tsuchiya K, Sakamoto N, Okamoto R, Watanabe M
- Journal Title
  
  Eur J Immunol 38(5)
  
  Pages: 1275-86
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] Blockade of NKG2D signaling prevents the development of murine CD4+ T cell-mediated colitis2008
- Author(s)
  Ito Y, Kanai T, Totsuka T, Okamoto R, Tsuchiya K, Nemoto Y, Yoshioka A, Tomita T, Nagaishi T, Sakamoto N, Sakanishi T, Okumura K, Yagita H, Watanabe M
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol 294(1)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] Proteasomal degradation of Atohl by aberrant Wnt signaling maintains the undifferentiated state of colon cancer.2008
- Author(s)
  Aragaki M, Tsuchiya K, Okamoto R, et. al.
- Journal Title
  
  Biochem Biophys Res Commun. 368
  
  Pages: 923-929
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] Flagellin stimulation suppresses IL-7 secretion of intestinal epithelial cells.2008
- Author(s)
  Yoshioka A, Okamoto R, et al.
- Journal Title
  
  Cytokine. 44
  
  Pages: 57-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] Colitogenic CD4(+)effector-memory T cells activelyrecirculate in chronic colitic mice2008
- Author(s)
  Tomita T, Kanai T, Nemoto Y, FujiiT, Nozaki K, Okamoto R, Tsuchiya K, Nakamura T, Totsuka T, Watanabe M
- Journal Title
  
  Inflamm Bowel Dis (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] Proteasomal degradation of Atohl by aberrant Wnt signaling maintains the undifferentiated state of colon cancer.2008
- Author(s)
  Aragaki M, Tsuchiya K, Okamoto R, et al.
- Journal Title
  
  Biochem Biophys Res Commun. 368
  
  Pages: 923-929
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] Reciprocal targeting of Hathl and β-catenin by Wnt-glycogen synthase kinase 3 β in human colon cancer.2007
- Author(s)
  Tsuchiya K, Nakamura T, Okamoto R, et. al.
- Journal Title
  
  Gastroenterology 132
  
  Pages: 208-220
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] IL-7 Is essential for the development and the persistence of chronic colitis2007
- Author(s)
  Totsuka T, Kanai T, Nemoto Y, Makita S, Okamoto R, Tsuchiya K, Watanabe M
- Journal Title
  
  J Immunol 178(8)
  
  Pages: 4737-48
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] Bone Marrow Retaining Colitogenic CD4(+) T Cells May Be a Pathogenic Reservoir for Chronic Colitis2007
- Author(s)
  Nemoto Y, Kanai T, Makita S, OkamotoR, Totsuka T, Takeda K, Watanabe M
- Journal Title
  
  Gastroenterology 132(1)
  
  Pages: 176-189
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] Intestinal lamina propria retaining CD4+CD25+regulatory T cells is a suppressive site of intestinal inflammation2007
- Author(s)
  Makita S, Kanai T, Nemoto Y, Totsuka T, Okamoto R, Tsuchiya K, Yamamoto M, Kiyono H, Watanabe M
- Journal Title
  
  J Immunol 178(8)
  
  Pages: 4937-46
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] Reciprocal targeting of Hath1 and beta-cateninby Wnt-glycogen synthase kinase 3 beta in human colon cancer2007
- Author(s)
  Tsuchiya K, Nakamura T, Okamoto R, Kanai T, Watanabe M
- Journal Title
  
  Gastroenterology 132(1)
  
  Pages: 208-220
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] Bone marrow retaining colitogenic CD4+ T cells may be a pathogenic reservoir for chronic colitis.2007
- Author(s)
  Nemoto Y, Kanai T, Makita S, Okamoto R, et. al.
- Journal Title
  
  Gastroenterology 132
  
  Pages: 176-189
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Presentation] Synergy of Notch Signaling and TNF-alpha Leads to Up-regulation of UBD in the Inflamed Intestinal Epithelia of IBD Patients2019
- Author(s)
  Kawamoto A, Nagata S, Anzai S, Okamoto R, Mamoru Watanabe et al.
- Organizer
  AOCC 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05284
[Presentation] Synergy of Notch signalling and TNF-alpha in the inflamed intestinal epithelia of IBD patients leads to up-regulation of UBD, a ubiquitin-like protein.2019
- Author(s)
  Kawamoto A, Nagata S, Anzai S, Okamoto R, Mamoru Watanabe et al.
- Organizer
  14th ECCO
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05284
[Presentation] クローン病由来の小腸上皮オルガノイド構築による幹細胞形質の解析2018
- Author(s)
  鈴木康平, 村野竜朗, 平栗優衣, 高橋純一, 河本亜美, 石橋史明 , 安斎　翔, 久野玲子, 桒原小の実, 川井麻央, 永田紗矢香, 油井史郎, 土屋輝一郎, 中村哲也, 大塚和朗, 渡辺　守, 岡本隆一
- Organizer
  第17回再生医療学会総会
- Data Source
  KAKENHI-PROJECT-16H05284
[Presentation] Jagged1 is indispensable for the maintenance of tumor stem cell niche in APC-Deficient intestinal adenomas2016
- Author(s)
  Toru Nakata, Go Ito, Hiromichi Shimizu, Satoru Fujii, Kohei Suzuki, Fumiaki Ishibashi, Ami Kawamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Katsuto Hozumi, Ryuichi Okamoto, Mamoru Watanabe
- Organizer
  DDW2016
- Place of Presentation
  サンディエゴ（米国）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05284
[Presentation] Single-cell level analysis reveals heterogeneous expression of stem-cell specific genes in human small intestinal organoids2016
- Author(s)
  Kohei Suzuki, Satoru Fujii, Ami Kawamoto, Fumiaki Ishibashi, Toru Nakata, Go Ito, Hiromichi Shimizu, Kiichiro Tsuchiya, Tetsuya Nakamura, Kazuo Otsuka, Ryuichi Okamoto, Mamoru Watanabe
- Organizer
  ion of stem-cell specific genes in human small intestinal organoidsDDW2016
- Place of Presentation
  サンディエゴ（米国）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05284
[Presentation] In vitro organoid model reveals PGE2 as a robust mediator of chloride & water secretion by human intestinal epithelial cells2016
- Author(s)
  Satoru Fujii, Kohei Suzuki, Ami Kawamoto, Fumiaki Ishibashi, Toru Nakata, Go Ito, Hiromichi Shimizu, Tomohiro Mizutani, Kiichiro Tsuchiya, Tetsuya Nakamura, Kazuo Ohtsuka, Ryuichi Okamoto, Mamoru Watanabe
- Organizer
  DDW2016
- Place of Presentation
  サンディエゴ（米国）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15286
[Presentation] Contiuous stimulation with cytokines leads to irreversible activation of NF-γb signaling in colonic epithelial cells by organoid culture.2015
- Author(s)
  Shuji Hibiya, Kiichiro Tsuchiya, Tomoaki Shirasaki, Keita Fukushima, Ryohei Hayashi, Nobukatsu Horita, Shigeru Oshima ,Ryuichi Okamoto, Tetsuya Nakamura,Mamoru Watanabe
- Organizer
  UEGW2015
- Place of Presentation
  バルセロナ（スペイン）
- Year and Date
  2015-10-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Enrichment of Intestinal Stem Cells by the 3D-Culture of IBD Patient Derived Intestinal epithelium.2015
- Author(s)
  Kohei Suzuki,Satoru Fujii,Toru Nakata,Ami Kawamoto,Fumiaki Ishibashi,Sayaka Ohashi Segawa, Tomohiro Mizutani, Kiichiro Tsuchiya,Kazuo Otsuka,Tetsuya Nakamura,Ryuichi Okamoto,Mamoru Watanabe.
- Organizer
  AOCC2015
- Place of Presentation
  ワシントン（米国）
- Year and Date
  2015-05-19
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] A novel fluorescent labelling system into small intestinal organoid reveals independent long-lived intestinal stem cells in a crypt.2015
- Author(s)
  Horita N,Tsuchiya K,Hayashi R,Fukushima K,Hibiya S,Fukuda M,Mizutani T,Okamoto R,Nakamura T and Watanabe M.
- Organizer
  AOCC2015
- Place of Presentation
  北京（中国）
- Year and Date
  2015-06-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Establishment of a 3D cell culture-based screening platform to identify natural products that can regulate transepithelial water transport of the human gastrointestinal tract.2015
- Author(s)
  Satoru Fujii, Ryuichi Okamoto, Toru Nakata, Kohei Suzuki, Fumiaki Ishibashi, Ami Kawamoto,Sayaka Ohashi Segawa, Tomohiro Mizutani, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe.
- Organizer
  Pacifichem2015
- Place of Presentation
  ハワイ（米国）
- Year and Date
  2015-12-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Contiuous stimulation with cytokines leads to irreversible activation of NF-γb signaling in colonic epithelial cells by organoid culture.2015
- Author(s)
  Shuji Hibiya, Kiichiro Tsuchiya, Tomoaki Shirasaki, Keita Fukushima, Ryohei Hayashi, Nobukatsu Horita, Shigeru Oshima ,Ryuichi Okamoto, Tetsuya Nakamura,Mamoru Watanabe
- Organizer
  UEGW2015
- Place of Presentation
  バルセロナ（スペイン）
- Year and Date
  2015-10-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15286
[Presentation] Notch Ligands DLL1 and Dll4 Are Expressed by Distinct Population of Epithelial Cells in the Mice Intestine.2015
- Author(s)
  Hiromichi Shimizu, Kohei Suzuki, Satoru Fujii, Toru Nakata, Go Ito, Tatsuro Murano, Kiichiro Tsuchiya, Tetsuya Nakamura, Ryuichi Okamoto, Katsuto Hozumi, Mamoru Watanabe.
- Organizer
  DDW 2015
- Place of Presentation
  ワシントン（米国）
- Year and Date
  2015-05-16
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Atoh1 protein stabilized by TNF-α acquires enhanced malignant potential in colitis-associated colorectal cancer.2015
- Author(s)
  Tomoaki Shirasaki, Keita Fukushima, Kiichiro Tsuchiya, Shuuji Hibiya, Ryohei Hayashi, Nobukatsu Horita, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe.
- Organizer
  AOCC2015
- Place of Presentation
  北京（中国）
- Year and Date
  2015-06-19
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Atoh1 protein stabilized by TNF-α acquires enhanced malignant potential in colitis-associated colorectal cancer.2015
- Author(s)
  Tomoaki Shirasaki, Keita Fukushima, Kiichiro Tsuchiya, Shuuji Hibiya, Ryohei Hayashi, Nobukatsu Horita, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe.
- Organizer
  AOCC2015
- Place of Presentation
  北京（中国）
- Year and Date
  2015-06-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Atoh1 Protein Expression by TNF-a and the Acquisition of Malignant Potential in Colitis- Associated Colorectal Cancer.2015
- Author(s)
  Keita Fukushima, Kiichiro Tsuchiya, Shuji Hibiya, Ryohei Hayashi, Nobukatsu Horita, Yoshihito Kano, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe.
- Organizer
  DDW 2015
- Place of Presentation
  ワシントン（米国）
- Year and Date
  2015-05-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Enrichment of Intestinal Stem Cells by the 3D-Culture of IBD Patient Derived Intestinal epithelium.2015
- Author(s)
  Kohei Suzuki,Satoru Fujii,Toru Nakata,Ami Kawamoto,Fumiaki Ishibashi,Sayaka Ohashi Segawa, Tomohiro Mizutani, Kiichiro Tsuchiya,Kazuo Otsuka,Tetsuya Nakamura,Ryuichi Okamoto,Mamoru Watanabe.
- Organizer
  AOCC2015
- Place of Presentation
  北京（中国）
- Year and Date
  2015-06-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15286
[Presentation] Notch Ligands DLL1 and Dll4 Are Expressed by Distinct Population of Epithelial Cells in the Mice Intestine.2015
- Author(s)
  Hiromichi Shimizu, Kohei Suzuki, Satoru Fujii, Toru Nakata, Go Ito, Tatsuro Murano, Kiichiro Tsuchiya, Tetsuya Nakamura, Ryuichi Okamoto, Katsuto Hozumi, Mamoru Watanabe.
- Organizer
  DDW 2015
- Place of Presentation
  ワシントン（米国）
- Year and Date
  2015-05-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15286
[Presentation] Notch Ligands DLL1 and Dll4 Are Expressed by Distinct Population of Epithelial Cells in the Mice Intestine.2015
- Author(s)
  Hiromichi Shimizu, Kohei Suzuki, Satoru Fujii, Toru Nakata, Go Ito, Tatsuro Murano, Kiichiro Tsuchiya, Tetsuya Nakamura, Ryuichi Okamoto, Katsuto Hozumi, Mamoru Watanabe.
- Organizer
  DDW 2015
- Place of Presentation
  ワシントン；米国
- Year and Date
  2015-05-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Establishment of a 3D cell culture-based screening platform to identify natural products that can regulate transepithelial water transport of the human gastrointestinal tract.2015
- Author(s)
  Satoru Fujii, Ryuichi Okamoto, Toru Nakata, Kohei Suzuki, Fumiaki Ishibashi, Ami Kawamoto,Sayaka Ohashi Segawa, Tomohiro Mizutani, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe.
- Organizer
  Pacifichem2015
- Place of Presentation
  ハワイ（米国）
- Year and Date
  2015-12-17
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Enrichment of Intestinal Stem Cells by the 3D-Culture of IBD Patient Derived Intestinal epithelium.2015
- Author(s)
  Kohei Suzuki,Satoru Fujii,Toru Nakata,Ami Kawamoto,Fumiaki Ishibashi,Sayaka Ohashi Segawa, Tomohiro Mizutani, Kiichiro Tsuchiya,Kazuo Otsuka,Tetsuya Nakamura,Ryuichi Okamoto,Mamoru Watanabe.
- Organizer
  AOCC2015
- Place of Presentation
  北京（中国）
- Year and Date
  2015-06-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Distinct Role of Notch Ligands, DLL1 and Dll4, in Normal and in Tumor Intestinal Epithelium.2015
- Author(s)
  Toru Nakata, Hiromichi Shimizu, Kohei Suzuki, Satoru Fujii, Go Ito, Kiichiro Tsuchiya, Tetsuya Nakamura, Ryuichi Okamoto, Katsuto Hozumi, Mamoru Watanabe.
- Organizer
  DDW 2015
- Place of Presentation
  ワシントン（米国）
- Year and Date
  2015-05-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Establishment of a 3D cell culture-based screening platform to identify natural products that can regulate transepithelial water transport of the human gastrointestinal tract.2015
- Author(s)
  Satoru Fujii, Ryuichi Okamoto, Toru Nakata, Kohei Suzuki, Fumiaki Ishibashi, Ami Kawamoto,Sayaka Ohashi Segawa, Tomohiro Mizutani, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe.
- Organizer
  Pacifichem2015
- Place of Presentation
  ハワイ（米国）
- Year and Date
  2015-12-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15286
[Presentation] A novel fluorescent labelling system into small intestinal organoid reveals independent long-lived intestinal stem cells in a crypt.2015
- Author(s)
  Horita N,Tsuchiya K,Hayashi R,Fukushima K,Hibiya S,Fukuda M,Mizutani T,Okamoto R,Nakamura T and Watanabe M.
- Organizer
  AOCC2015
- Place of Presentation
  北京（中国）
- Year and Date
  2015-06-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15286
[Presentation] A novel fluorescent labelling system into small intestinal organoid reveals independent long-lived intestinal stem cells in a crypt.2015
- Author(s)
  Horita N,Tsuchiya K,Hayashi R,Fukushima K,Hibiya S,Fukuda M,Mizutani T,Okamoto R,Nakamura T and Watanabe M.
- Organizer
  AOCC2015
- Place of Presentation
  北京（中国）
- Year and Date
  2015-06-19
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] TNF-α stabilizes atoh1 protein in colitis-associated colorectal cancer resulting in enhanced malignant potential.2015
- Author(s)
  Tomoaki Shirasaki, Keita Fukushima, Kiichiro Tsuchiya, Shuuji Hibiya, Ryohei Hayashi, Nobukatsu Horita, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe.
- Organizer
  UEGW2015
- Place of Presentation
  バルセロナ（スペイン）
- Year and Date
  2015-10-28
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Distinct Role of Notch Ligands, DLL1 and Dll4, in Normal and in Tumor Intestinal Epithelium.2015
- Author(s)
  Toru Nakata, Hiromichi Shimizu, Kohei Suzuki, Satoru Fujii, Go Ito, Kiichiro Tsuchiya, Tetsuya Nakamura, Ryuichi Okamoto, Katsuto Hozumi, Mamoru Watanabe.
- Organizer
  DDW 2015
- Place of Presentation
  ワシントン（米国）
- Year and Date
  2015-05-19
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Continuous Stimulation With Cytokines Leads to Irreversible Accumulation of NF-kB Signaling in Colonic Epithelial Cells.2015
- Author(s)
  Shuji Hibiya, Kiichiro Tsuchiya, Keita Fukushima, Ryohei Hayashi, Nobukatsu Horita, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe.
- Organizer
  DDW 2015
- Place of Presentation
  ワシントン（米国）
- Year and Date
  2015-05-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Continuous Stimulation With Cytokines Leads to Irreversible Accumulation of NF-kB Signaling in Colonic Epithelial Cells.2015
- Author(s)
  Shuji Hibiya, Kiichiro Tsuchiya, Keita Fukushima, Ryohei Hayashi, Nobukatsu Horita, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe.
- Organizer
  DDW 2015
- Place of Presentation
  ワシントン（米国）
- Year and Date
  2015-05-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15286
[Presentation] TNF-α stabilizes atoh1 protein in colitis-associated colorectal cancer resulting in enhanced malignant potential.2015
- Author(s)
  Tomoaki Shirasaki, Keita Fukushima, Kiichiro Tsuchiya, Shuuji Hibiya, Ryohei Hayashi, Nobukatsu Horita, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe.
- Organizer
  UEGW2015
- Place of Presentation
  バルセロナ（スペイン）
- Year and Date
  2015-10-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Distinct Role of Notch Ligands, DLL1 and Dll4, in Normal and in Tumor Intestinal Epithelium.2015
- Author(s)
  Toru Nakata, Hiromichi Shimizu, Kohei Suzuki, Satoru Fujii, Go Ito, Kiichiro Tsuchiya, Tetsuya Nakamura, Ryuichi Okamoto, Katsuto Hozumi, Mamoru Watanabe.
- Organizer
  DDW 2015
- Place of Presentation
  ワシントン（米国）
- Year and Date
  2015-05-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15286
[Presentation] Distinct Expression Patterns of Notch Ligands, DLL1 and DLL4, in Normal and Inflamed Mice Intestine2014
- Author(s)
  Hiromichi Shimizu, Ryuichi Okamoto, Go Ito, Satoru Fujii, Toru Nakata, Kohei Suzuki, Tatsuro Murano, Tomohiro Mizutani, Kiichiro Tsuchiya, Tetsuya Nakamura, Katsuto Hozumi, Mamoru Watanabe
- Organizer
  The 2nd Annual Meeting of Asian Organization for Crohn's and Colitis
- Place of Presentation
  Seoul (Korea)
- Year and Date
  2014-06-21
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Distinct Expression Patterns of Notch Ligands, DLL1 and DLL4, in Normal and Inflamed Mice Intestine.2014
- Author(s)
  Hiromichi Shimizu, Ryuichi Okamoto, Go Ito, Satoru Fujii, Toru Nakata, Kohei Suzuki, Tatsuro Murano, Tomohiro Mizutani, Kiichiro Tsuchiya, Tetsuya Nakamura, Katsuto Hozumi, Mamoru Watanabe.
- Organizer
  The 2nd Annual Meeting of Asian Organization for Crohn's and Colitis
- Place of Presentation
  Seoul (Korea)
- Year and Date
  2014-06-21
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Notch signaling regulates expression of gelsolin superfamily genes, gelsolim and scinderin and promotes re-assembly of action cytoskeleton in human intestinal epithelial cells.2014
- Author(s)
  Ryuichi Okamoto, Go Ito, Hiromichi Shimizu, Satoru Fujii , Toru Nakata, Kohei Suzuki, Mamoru Watanabe.
- Organizer
  UEGW2014
- Place of Presentation
  Vienna (Austria)
- Year and Date
  2014-10-22
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Notch Signaling and TNF-alpha synergistically promotes intracellular protein accumulation of olfm4 in the inflamed mucosa of ulcerative colitis.2014
- Author(s)
  Go Ito, Ryuichi Okamoto, Hiromichi Shimizu, Satoru Fujii, Toru Nakata, Kohei Suzuki, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe.
- Organizer
  UEGW2014
- Place of Presentation
  Vienna (Austria)
- Year and Date
  2014-10-21
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Notch signaling and TNF-α synergistically promotes intracellular protein expression of OLFM4 in human intestinal epithelial cells.2014
- Author(s)
  Go Ito, Ryuichi Okamoto, Hiromichi Shimizu, Satoru Fujii, Toru Nakata, Kohei Suzuki, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe.
- Organizer
  The 2nd Annual Meeting of Asian Organization for Crohn's and Colitis
- Place of Presentation
  Seoul (Korea)
- Year and Date
  2014-06-21
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Notch signaling regulates expression of gelsolin superfamily genes, gelsolim and scinderin and promotes re-assembly of action cytoskeleton in human intestinal epithelial cells.2014
- Author(s)
  Ryuichi Okamoto, Go Ito, Hiromichi Shimizu, Satoru Fujii , Toru Nakata, Kohei Suzuki, Mamoru Watanabe.
- Organizer
  UEGW2014
- Place of Presentation
  Vienna (Austria)
- Year and Date
  2014-10-22
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Notch signaling and TNF-α synergistically up-regulates expression of OLFM4 in human intestinal epithelial cells.2014
- Author(s)
  Go Ito, Ryuichi Okamoto, Tasturo Murano, Hiromichi Shimizu, Satoru Fujii, Toru Nakata, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe .
- Organizer
  第8回Japan-US Collabaration Conference in Gastroenterology
- Place of Presentation
  Intercontinental TOKYO BAY (東京都港区海岸1-16-2)
- Year and Date
  2014-11-21
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Notch signaling and TNF-α synergistically promotes intracellular protein expression of OLFM4 in human intestinal epithelial cells.2014
- Author(s)
  Go Ito, Ryuichi Okamoto, Hiromichi Shimizu, Satoru Fujii, Toru Nakata, Kohei Suzuki, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe.
- Organizer
  The 2nd Annual Meeting of Asian Organization for Crohn's and Colitis
- Place of Presentation
  Seoul (Korea)
- Year and Date
  2014-06-21
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Notch Signaling and TNF-alpha synergistically promotes intracellular protein accumulation of olfm4 in the inflamed mucosa of ulcerative colitis.2014
- Author(s)
  Go Ito, Ryuichi Okamoto, Hiromichi Shimizu, Satoru Fujii, Toru Nakata, Kohei Suzuki, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe
- Organizer
  UEGW2014
- Place of Presentation
  Vienna (Austria)
- Year and Date
  2014-10-21
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Notch signaling and TNF-α synergistically up-regulates expression of OLFM4 in human intestinal epithelial cells.2014
- Author(s)
  Go Ito, Ryuichi Okamoto, Tasturo Murano, Hiromichi Shimizu, Satoru Fujii, Toru Nakata, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe
- Organizer
  第8回Japan-US Collabaration Conference in Gastroenterology
- Place of Presentation
  Intercontinental TOKYO BAY (東京都港区海岸1-16-2)
- Year and Date
  2014-11-21
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] 炎症性腸疾患における上皮再生機構の解明と粘膜再生治療への応用2013
- Author(s)
  岡本隆一、村野竜朗、渡辺　守
- Organizer
  第99回日本消化器病学会総会
- Place of Presentation
  鹿児島
- Year and Date
  2013-03-21
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] 炎症性腸疾患における上皮再生機構の解明と粘膜再生治療への応用2013
- Author(s)
  岡本隆一、村野竜朗、渡辺守
- Organizer
  第99回日本消化器病学会総会
- Place of Presentation
  鹿児島
- Year and Date
  2013-03-23
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] 腸管上皮Notch-Hes1シグナルによるIL-22誘導性抗菌応答の制御2013
- Author(s)
  村野竜朗、岡本隆一、渡辺守
- Organizer
  第31回サイトプロテクション研究会
- Place of Presentation
  京都
- Year and Date
  2013-03-15
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] Notch signaling regulates expression of Gelsolin superfamily genes, Gelsolin and Scinderin, and promotes re-assembly of actin cytoskelton in human intestinal epithelial cells.2012
- Author(s)
  Okamoto R, Nakamura T, Watanabe M et al
- Organizer
  DDW2012
- Place of Presentation
  San Diego
- Year and Date
  2012-05-21
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Regeneration of damaged colon epithelium by transplanted colon Lgr5+ stem cells maintained and expanded in vitro2012
- Author(s)
  Yui S, Nakamura T, Nemoto Y, Mizutani T, Fukuda M, Nozaki K, Yamauchi Y, Mochizuki W, Zheng X, Nagaishi T, Okamoto R, Tsuchiya K, Watanabe M
- Organizer
  第10回幹細胞シンポジウム.
- Place of Presentation
  淡路島
- Year and Date
  2012-06-01
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] The acquisition of cancer stemness in colon cancer by the Atoh1 protein stabilization2012
- Author(s)
  Kano Y, Tsuchiya K, Horita N, Zheng X, Okamoto R, Nakamura T, Watanabe M
- Organizer
  DDW2012.
- Place of Presentation
  San Diego
- Year and Date
  2012-05-19
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] Notch-Hes1 pathway and TNF- synergistically up-regulates OLFM4 expression in the inflamed mucosa of the human intestine2012
- Author(s)
  Ryuichi Okamoto, Go Ito, SatoruFujii, Hiromichi Shimizu, Tatsuro Murano, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe
- Organizer
  6thKorea-Japan IBD Symposium
- Place of Presentation
  Tokyo
- Year and Date
  2012-01-28
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] Notch signaling regulates expression of Gelsolin superfamily genes, Gelsolin and Scinderin, and promotes re-assembly of actin cytoskelton in human intestinal epithelial cells2012
- Author(s)
  Ryuichi Okamoto,Tatsuro Murano, Go Ito, Satoru Fujii, Hiromichi Shimizu, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe
- Organizer
  DDW 2012
- Place of Presentation
  SanDiego
- Year and Date
  2012-05-21
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] Hes1 promotes IL-22-mediated epithelial regeneration through enhancement of STAT3-dependent transcription in human intestinal epithelial cells2012
- Author(s)
  Tatsuro Murano, Ryuichi Okamoto, Go Ito, Satoru Fujii, Hiromichi Shimizu, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe
- Organizer
  DDW 2012
- Place of Presentation
  SanDiego
- Year and Date
  2012-05-19
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] The acquisition of cancer stemness in colon cancer by the Atoh1 protein stabilization2012
- Author(s)
  Kano Y, Tsuchiya K, Horita N, Zheng X, Okamoto R, Nakamura T, Watanabe M
- Organizer
  ISSCR2012.
- Place of Presentation
  Yokohama
- Year and Date
  2012-06-14
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] The acquisition of cancer stemness in colon cancer by the Atoh1 protein stabilization.2012
- Author(s)
  Kano Y, Okamoto R, Nakamura T, Watanabe M et al
- Organizer
  ISSCR2012
- Place of Presentation
  横浜
- Year and Date
  2012-06-14
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Real-time analysis of p-glycoprotein-mediated drug transport across primary intestinal epitherial cells three-dimensionally cultured in vitro.2012
- Author(s)
  Mizutani T, Nakamura T, Okamoto R, Watanabe M　et al
- Organizer
  DDW2012
- Place of Presentation
  San Diego
- Year and Date
  2012-05-21
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Hes1 promotes IL-22-Mediated epithelial regeneration through enhancement of STAT3-Dpendent transcription in human intestinal epithelial cells.2012
- Author(s)
  Murano T, Okamoto R, Nakamura T, Watanabe M et al
- Organizer
  DDW2012
- Place of Presentation
  San Diego
- Year and Date
  2012-05-19
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Notch pathway and TNF-a synergistically up-regulatesOLFM4 expression in the inflamed mucosa of the human intestine2012
- Author(s)
  Ryuichi Okamoto, Morio-AkiyamaJunko, Hiromichi Shimizu, Tatsuro Murano, Go Ito, Satoru Fujii, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe
- Organizer
  Asian IBD Symposium Seoul 2012.
- Place of Presentation
  Seoul
- Year and Date
  2012-11-03
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] Colitogenic effector memory CD4+ T cells develop TH1/TH17 mediated interstitial pneumonia independent to intestinal bacterial antigens2012
- Author(s)
  Nemoto Y, Kanai T, Okamoto R, Tsuchiya K, Nakamura T, Matsumoto S, Watanabe M
- Organizer
  AGA.
- Place of Presentation
  San Diego
- Year and Date
  2012-05-22
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] Notch signaling and TNF-alpha synergistically up-regulate OLFM4expression in human intestinal epithelial cells2012
- Author(s)
  Ryuichi Okamoto, Go Ito, Satoru Fujii, Hiromichi Shimizu, Tatsuro Murano, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe
- Organizer
  UEGW2012
- Place of Presentation
  Amsterdam
- Year and Date
  2012-11-23
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] Notch signaling regulates expression of Bestrophin-4, a novelenterocyte-specific HCO3-/Cl- channel, in human intestinal epithelial cells2012
- Author(s)
  Go Ito, Ryuichi Okamoto, Satoru Fujii, Hiromichi Shimizu, Tatsuro Murano, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe
- Organizer
  UEGW2012
- Place of Presentation
  Amsterdam
- Year and Date
  2012-11-23
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] Notch pathway and TNF-a synergistically up-regulates OLFM4 expression in the inflamed mucosa of the human intestine.2012
- Author(s)
  Okamoto R, Watanabe M et al
- Organizer
  Asian IBD Symposium Seoul 2012
- Place of Presentation
  Seoul
- Year and Date
  2012-11-03
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Flagellin response via TLR5 on basolateral membrane of primary intestinal epithelial cells is regulated by Notch signaling.2012
- Author(s)
  Tsuchiya K, Okamoto R, Nakamura T, Watanabe M et al
- Organizer
  DDW2012
- Place of Presentation
  San Diego
- Year and Date
  2012-05-22
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Identification of Notch ligand expressing cells in normal and inflamed intestinal mucosa2012
- Author(s)
  Hiromichi Shimizu, Ryuichi Okamoto, Tatsuro Murano, Go Ito, Satoru Fujii, Morio-Akiyama Junko, Kiichiro Tsuchiya, Tetsuya Nakamura, MamoruWatanabe
- Organizer
  Asian IBD Symposium Seoul 2012.
- Place of Presentation
  Seoul
- Year and Date
  2012-11-03
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] Hes1 promotes IL-22-mediated epithelial regeneration through enhancement of STAT3-dependent transcription in human intestinal epithelial cells2012
- Author(s)
  Tatsuro Murano, Ryuichi Okamoto, Go Ito, Satoru Fujii, Hiromichi Shimizu, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe
- Organizer
  6th Korea-Japan IBD Symposium
- Place of Presentation
  Tokyo
- Year and Date
  2012-01-28
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] Establishment of novel bio-screening methods using cultured intestinal epithelial cells2012
- Author(s)
  Okamoto R
- Organizer
  The 1st International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity.
- Place of Presentation
  Kyoto
- Year and Date
  2012-10-31
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] Regeneration of damaged colon epithelium by transplanted colon Lgr5+ stem cells maintained and expanded in vitro.2012
- Author(s)
  Yui S, Nakamura T, Okamoto R, Watanabe M et al
- Organizer
  第10回幹細胞シンポジウム
- Place of Presentation
  淡路島
- Year and Date
  2012-06-01
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Real-time analysis of p-glycoprotein-mediated drugtransport across primary intestinal epithelial cellsthree-dimensionally cultured in vitro2012
- Author(s)
  Mizutani T, Nakamura T, Morikawa R, Fukuda M, Mochizuki W, Yamauchi Y, Nozaki K, Yui S, Okamoto R, Tsuchiya K, Watanabe M
- Organizer
  DDW2012.
- Place of Presentation
  San Diego
- Year and Date
  2012-05-21
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] The acquisition of cancer stemness in colon cancer by the Atoh1 protein stabilization.2012
- Author(s)
  Kano Y, Okamoto R, Nakamura T, Watanabe M　et al
- Organizer
  DDW2012
- Place of Presentation
  San Diego
- Year and Date
  2012-05-19
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Colitogenic effector memory CD4+ T cells develop TH1/TH17 mediated interstitial pneumonia independent to intestinal bacterial antigens.2012
- Author(s)
  Nemoto Y, Okamoto R, Nakamura T, Watanabe M et al
- Organizer
  DDW2012
- Place of Presentation
  San Diego
- Year and Date
  2012-05-22
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Hes1 promotes IL-22-mediated epithelial regeneration through enheancement of STAT3-dependent transcription in human intestinal epithelial cells.2012
- Author(s)
  Okamoto R, Watanabe M et al
- Organizer
  Asian IBD Symposium Seoul 2012
- Place of Presentation
  Seoul
- Year and Date
  2012-11-03
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Establishment of novel bio-screening methods using cultured intestinal epithelial cells .2012
- Author(s)
  Okamoto R
- Organizer
  The 1st International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity
- Place of Presentation
  京都
- Year and Date
  2012-10-31
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Notch-Hes1 pathway and TNF-α synergistically up-regulates OLFM4 expression in the inflamed mucosa of the human intestine.2011
- Author(s)
  Okamoto R. et al.
- Organizer
  DDW 2011.
- Place of Presentation
  シカゴ
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] Regeneration of damaged colonic tissue by transplanted colonic epithelial stem cells maintained and expanded in vitro2011
- Author(s)
  Yui S., Okamoto R., et al
- Organizer
  GI Research Academy 2011
- Place of Presentation
  京都
- Year and Date
  2011-06-17
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Notch-Hes1 pathway and TNF-α synergistically up-regulates OLFM4 expression in the inflamed mucosa of the human intestine2011
- Author(s)
  Okamoto R., et al
- Organizer
  DDW 2011
- Place of Presentation
  シカゴ
- Year and Date
  2011-05-07
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Regeneration of damaged colonic tissue by transplanted colonic epithelial stem cells maintained and expanded in vitro.2011
- Author(s)
  Yui S., Okamoto R. et al.
- Organizer
  GI Research Academy 2011.
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] Regeneration of damaged colonic tissue by transplantation of colonic epithelial stem cells maintained and expanded in vitro2011
- Author(s)
  Yui S, Nakamura T, Nagaishi T, Okamoto R, Watanabe M, et al.
- Organizer
  アメリカ消化器病学会
- Place of Presentation
  シカゴ
- Year and Date
  2011-05-07
- Data Source
  KAKENHI-PROJECT-21590806
[Presentation] 炎症性腸疾患と上皮再生2010
- Author(s)
  岡本隆一
- Organizer
  第31回日本炎症・再生医学会
- Place of Presentation
  東京
- Year and Date
  2010-08-05
- Data Source
  KAKENHI-PROJECT-21790651
[Presentation] 炎症性腸疾患における粘膜修復機構の解析と上皮再生治療への応用2010
- Author(s)
  岡本隆一
- Organizer
  第6回日本消化管学会総会
- Place of Presentation
  福岡
- Year and Date
  2010-02-19
- Data Source
  KAKENHI-PROJECT-21790651
[Presentation] Up-regulation of Delta1 expression is required for goblet cell differentiation in human intestinal epithelial cells2010
- Author(s)
  Akiyama J., Okamoto R., et al.
- Organizer
  Digestive Disease Week 2010
- Place of Presentation
  ニューオリンズ
- Year and Date
  2010-05-04
- Data Source
  KAKENHI-PROJECT-21790651
[Presentation] A well-defined culture system for colonic epithelial cells that allows efficient enrichment of LGR5+stem cells2010
- Author(s)
  Yui S, Nagaishi T, Okamoto R, Watanabe M, et al
- Organizer
  The 1st JSGE International Topic Conference-Stem cells in digestive organs
- Place of Presentation
  鎌倉
- Year and Date
  2010-09-26
- Data Source
  KAKENHI-PROJECT-21590806
[Presentation] Up-regulation of Delta1 expression is required for goblet cell differentiation in human intestinal epithelial cells2010
- Author(s)
  秋山純子、岡本隆一
- Organizer
  米国消化器病学会週間2010
- Place of Presentation
  ニューオリンズ
- Year and Date
  2010-05-04
- Data Source
  KAKENHI-PROJECT-21790651
[Presentation] TNF-α and Notch signaling synergistically up-regulate OLFM4 expression in human intestinal epithelial cells2010
- Author(s)
  Okamoto R., et al.
- Organizer
  Digestive Disease Week 2010
- Place of Presentation
  ニューオリンズ
- Year and Date
  2010-05-05
- Data Source
  KAKENHI-PROJECT-21790651
[Presentation] 炎症性腸疾患における Notch シグナルを介した上皮再生機構2010
- Author(s)
  岡本隆一, 他
- Organizer
  第6回日本消化管学会総会学術集会
- Place of Presentation
  福岡
- Year and Date
  2010-02-19
- Data Source
  KAKENHI-PROJECT-21790651
[Presentation] TNF-alpha and Notch signaling synergistically up-regulate OLFM4 expression in human intestinal epithelial cells2010
- Author(s)
  岡本隆一
- Organizer
  米国消化器病学会週間2010
- Place of Presentation
  ニューオリンズ
- Year and Date
  2010-05-05
- Data Source
  KAKENHI-PROJECT-21790651
[Presentation] 炎症性腸疾患における上皮分化・増殖機構の解析と粘膜再生治療への応用2009
- Author(s)
  岡本隆一
- Organizer
  日本消化器病学会週間
- Place of Presentation
  京都
- Year and Date
  2009-10-16
- Data Source
  KAKENHI-PROJECT-21790651
[Presentation] Notchl activation promotes goblet cell depletion and expression of PLA2G2A in the inflamed mucosa of ulcerative colitis2009
- Author(s)
  岡本隆一, et al
- Organizer
  Digestive Disease Week 2009
- Place of Presentation
  シカゴ
- Year and Date
  2009-06-01
- Data Source
  KAKENHI-PROJECT-21790651
[Presentation] Expression of Delta ligands is regulated by Notch-Hes1 signaling pathway in human intestinal epithelial cells2009
- Author(s)
  秋山純子、岡本隆一
- Organizer
  The Notch Meeting
- Place of Presentation
  アテネ
- Year and Date
  2009-09-27
- Data Source
  KAKENHI-PROJECT-21790651
[Presentation] Notch1 activation promotes goblet cell depletion and expression of PLA2G2A in the inflamed mucosa of ulcerative colitis2009
- Author(s)
  岡本隆一
- Organizer
  米国消化器病学会週間2009
- Place of Presentation
  シカゴ
- Year and Date
  2009-06-01
- Data Source
  KAKENHI-PROJECT-21790651
[Presentation] 炎症性腸疾患における上皮分化・増殖機構の解析と粘膜再生治療への応用2009
- Author(s)
  岡本隆一, 他
- Organizer
  JDDW 2009
- Place of Presentation
  京都
- Year and Date
  2009-10-16
- Data Source
  KAKENHI-PROJECT-21790651
[Presentation] Notch1 activation promotes goblet cell depletion and expression of PLA2G2A in the inflamed mucosa ofulcerative colitis2009
- Author(s)
  岡本隆一
- Organizer
  The Notch Meeting
- Place of Presentation
  アテネ
- Year and Date
  2009-09-27
- Data Source
  KAKENHI-PROJECT-21790651
[Presentation] Notch signaling suppresses the transcriptional activity of Hathl Gene, resulting in the undifferentiated form of human intestinal epithelial cells2008
- Author(s)
  Tsuchiya K, Inoue K, Aragaki M, Okamoto R et.al.
- Organizer
  DDW 2008
- Place of Presentation
  San Diego
- Year and Date
  2008-05-20
- Data Source
  KAKENHI-PROJECT-19890064
[Presentation] Dysregulated differentiation of intestinal epithelia in UC.2008
- Author(s)
  Okamoto R, Tsuchiya K
- Organizer
  3rd Japan-Korea IBD Symposium
- Place of Presentation
  ソウル
- Year and Date
  2008-09-20
- Data Source
  KAKENHI-PROJECT-19890064
[Presentation] Neutralization of tumor necrosis factor suppresses the development of colitis-associated tumor in mice2008
- Author(s)
  Onizawa M, Nagaishi T, Nemoto Y, Oshima S, Okamoto R, et.al.
- Organizer
  DDW2008
- Place of Presentation
  San Diego
- Year and Date
  2008-05-21
- Data Source
  KAKENHI-PROJECT-19890064
[Presentation] Tsuchiya : Dysregulated differentiation of intestinal epithelia in UC2008
- Author(s)
  Okamoto R
- Organizer
  3rd Japan-Korea IBD Symposium
- Place of Presentation
  ソウル
- Year and Date
  2008-09-20
- Data Source
  KAKENHI-PROJECT-19890064
[Presentation] Notch signaling suppresses the transcriptional activity of Hath1 Gene, resulting in the undifferentiated form of human intestinal epithelial cells.2008
- Author(s)
  Tsuchiya K, Inoue K, Aragaki M, Okamoto R, et al.
- Organizer
  DDW 2008
- Place of Presentation
  San Diego
- Year and Date
  2008-05-20
- Data Source
  KAKENHI-PROJECT-19890064
[Presentation] Neutralization of tumor necrosis factor suppresses the development of colitis-associated tumor in mice.2008
- Author(s)
  Onizawa M, Nagaishi T, Nemoto Y, Oshima S, Okamoto R, et al.
- Organizer
  DDW 2008
- Place of Presentation
  San Diego
- Year and Date
  2008-05-21
- Data Source
  KAKENHI-PROJECT-19890064
[Presentation] Activated Notch Signalling Suppresses Generation of Goblet Cellsin the Human Intestinal Mucosa2007
- Author(s)
  Okamoto R
- Organizer
  DDW 2007
- Place of Presentation
  ワシントン
- Year and Date
  2007-05-20
- Data Source
  KAKENHI-PROJECT-19890064
[Presentation] Activated Notch Signalling Suppresses Generation of Goblet Cells in the Human Intestinal Mucosa2007
- Author(s)
  Okamoto R
- Organizer
  全米消化器病学会
- Place of Presentation
  米国(ワシントン)
- Year and Date
  2007-05-20
- Data Source
  KAKENHI-PROJECT-19890064
[Presentation] Role of Notch signaling in inflammatory bowel diseases2007
- Author(s)
  Okamoto R
- Organizer
  アジア太平洋消化器病学会
- Place of Presentation
  神戸
- Year and Date
  2007-10-16
- Data Source
  KAKENHI-PROJECT-19890064
[Presentation] Colitogenic effector memory CD4+ T cells develop TH1/TH17 mediated interstitial pneumonia independent to intestinal bacterial antigens.
- Author(s)
  Nemoto Y, Okamoto R, Nakamura T, Watanabe M et al
- Organizer
  DDW2012
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] The acquisition of cancer stemness in colon cancer by the Atoh1 protein stabilization.
- Author(s)
  Kano Y, Okamoto R, Nakamura T, Watanabe M　et al
- Organizer
  DDW2012
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] Lineage-specific expression of bestrophin genes in normal and inflamed human intestine: implications for ulcerative colitis.
- Author(s)
  Go Ito, Ryuichi Okamoto, Tatsuro Murano, Hiromichi Shimizu, Satoru Fujii, Kiichiro Tsuchiya, Tetsuya Nakamura, and Mamoru Watanabe
- Organizer
  The 1st Annual Meeting of Asian Organization for Crohn's and Colitis
- Place of Presentation
  東京、ラフォーレ東京
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Notch pathway and TNF-a synergistically up-regulates OLFM4 expression in the inflamed mucosa of the human intestine.
- Author(s)
  Okamoto R, Murano T, Watanabe M et al
- Organizer
  Asian IBD Symposium Seoul 2012
- Place of Presentation
  Seoul
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] 炎症性腸疾患における上皮再生機構の解明と粘膜再生治療への応用
- Author(s)
  岡本隆一、村野竜朗、渡辺　守
- Organizer
  第99回日本消化器病学会総会
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] COMPLETE CONVERSION OF CRYPT PROGENITOR CELLS INTO ATOH1-POSITIVE CELLS BY TARGETED DELETION OF DLL1 AND DLL4 IN LGR5-POSITIVE INTESTINAL STEM CELLS
- Author(s)
  H. Shimizu, R. Okamoto, T. Nakata, S. Fujii, G. Ito, T. Murano, K. Tsuchiya, T. Nakamura, M. Watanabe
- Organizer
  UEGW 2013
- Place of Presentation
  ベルリン、ドイツ
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Notch signaling regulates expression of Bestrophin-4, a novel enterocyte-specific HCO3-/Cl- channel, in human intestinal epithelial cells.
- Author(s)
  Go Ito, Ryuichi Okamoto, Satoru Fujii, Hiromichi Shimizu, Tatsuro Murano, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe
- Organizer
  DDW 2013
- Place of Presentation
  オーランド、米国
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Identification of Notch ligand expressing cells in normal and inflamed intestinal mucosa.
- Author(s)
  Shimizu H, Okamoto R, Watanabe M et al
- Organizer
  Asian IBD Symposium Seoul 2012
- Place of Presentation
  Seoul
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] Hes1 promotes IL-22-mediated antimicrobial response through enhancement of STAT3-dependent transcription in human intestinal epithelial cells
- Author(s)
  Ryuichi Okamoto, Tatsuro Murano, Hiromichi Shimizu, Go Ito, Satoru Fujii, Kiichiro Tsuchiya, Tetsuya Nakamura, and Mamoru Watanabe
- Organizer
  The 1st Annual Meeting of Asian Organization for Crohn's and Colitis
- Place of Presentation
  東京、ラフォーレ東京
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Complete conversion of crypt progenitor cells into Atoh1-positive cells by targeted deletion of Dll1 and Dll4 in Lgr5-positive intestinal stem cells
- Author(s)
  Hiromichi Shimizu, Ryuichi Okamoto, Satoru Fujii, Go Ito, Tatsuro Murano, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe
- Organizer
  DDW 2013
- Place of Presentation
  オーランド、米国
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Real-time analysis of p-glycoprotein-mediated drug transport across primary intestinal epitherial cells three-dimensionally cultured in vitro.
- Author(s)
  Mizutani T, Nakamura T, Okamoto R, Watanabe M　et al
- Organizer
  DDW2012
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] Hes1 promotes IL-22-mediated antimicrobial response through enhancement of STAT3-dependent transcription in human intestinal epithelial cells
- Author(s)
  Ryuichi Okamoto, Tatsuro Murano, Hiromichi Shimizu, Go Ito, Satoru Fujii, Kiichiro Tsuchiya, Tetsuya Nakamura, and Mamoru Watanabe
- Organizer
  The 1st Annual Meeting of Asian Organization for Crohn's and Colitis
- Place of Presentation
  東京、ラフォーレ東京
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Complete conversion of crypt progenitor cells into Atoh1-positive cells by targeted deletion of Dll1 and Dll4 in Lgr5-positive intestinal stem cells
- Author(s)
  Hiromichi Shimizu, Ryuichi Okamoto, Satoru Fujii, Go Ito, Tatsuro Murano, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe
- Organizer
  DDW 2013
- Place of Presentation
  オーランド、米国
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] LINEAGE-SPECIFIC EXPRESSION OF BESTROPHIN-2 AND BESTROPHIN-4 IS REGULATED BY NOTCH SIGNALING IN HUMAN INTESTINAL EPITHELIAL CELLS
- Author(s)
  G. Ito, R. Okamoto, T. Murano, H. Shimizu, K. Tsuchiya, T. Nakamura, M. Watanabe
- Organizer
  UEGW 2013
- Place of Presentation
  ベルリン、ドイツ
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] IL-22-MEDIATED ANTIMICROBIAL RESPONSE IS REGULATED BY HES1 VIA STAT3-DEPENDENT TRANSCRIPTION IN HUMAN INTESTINAL EPITHELIAL CELLS
- Author(s)
  R. Okamoto, T. Murano, H. Shimizu, G. Ito, S. Fujii, T. Nakata, K. Tsuchiya, T. Nakamura, M. Watanabe
- Organizer
  UEGW 2013
- Place of Presentation
  ベルリン、ドイツ
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] COMPLETE CONVERSION OF CRYPT PROGENITOR CELLS INTO ATOH1-POSITIVE CELLS BY TARGETED DELETION OF DLL1 AND DLL4 IN LGR5-POSITIVE INTESTINAL STEM CELLS
- Author(s)
  H. Shimizu, R. Okamoto, T. Nakata, S. Fujii, G. Ito, T. Murano, K. Tsuchiya, T. Nakamura, M. Watanabe
- Organizer
  UEGW 2013
- Place of Presentation
  ベルリン、ドイツ
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Hes1 promotes IL-22-Mediated epithelial regeneration through enhancement of STAT3-Dpendent transcription in human intestinal epithelial cells.
- Author(s)
  Murano T, Okamoto R, Nakamura T, Watanabe M et al
- Organizer
  DDW2012
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] Flagellin response via TLR5 on basolateral membrane of primary intestinal epithelial cells is regulated by Notch signaling.
- Author(s)
  Tsuchiya K, Okamoto R, Nakamura T, Watanabe M et al
- Organizer
  DDW2012
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] Notch signaling regulates expression of Bestrophin-4, a novel enterocyte-specific HCO3-/Cl- channel, in human intestinal epithelial cells.
- Author(s)
  Go Ito, Ryuichi Okamoto, Satoru Fujii, Hiromichi Shimizu, Tatsuro Murano, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe
- Organizer
  DDW 2013
- Place of Presentation
  オーランド、米国
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] IL-22-MEDIATED ANTIMICROBIAL RESPONSE IS REGULATED BY HES1 VIA STAT3-DEPENDENT TRANSCRIPTION IN HUMAN INTESTINAL EPITHELIAL CELLS
- Author(s)
  R. Okamoto, T. Murano, H. Shimizu, G. Ito, S. Fujii, T. Nakata, K. Tsuchiya, T. Nakamura, M. Watanabe
- Organizer
  UEGW 2013
- Place of Presentation
  ベルリン、ドイツ
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Notch signaling regulates expression of Gelsolin superfamily genes, Gelsolin and Scinderin, and promotes re-assembly of actin cytoskelton in human intestinal epithelial cells.
- Author(s)
  Okamoto R, Nakamura T, Watanabe M et al
- Organizer
  DDW2012
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] LINEAGE-SPECIFIC EXPRESSION OF BESTROPHIN-2 AND BESTROPHIN-4 IS REGULATED BY NOTCH SIGNALING IN HUMAN INTESTINAL EPITHELIAL CELLS
- Author(s)
  G. Ito , R. Okamoto, T. Murano, H. Shimizu, K. Tsuchiya, T. Nakamura, M. Watanabe
- Organizer
  UEGW 2013
- Place of Presentation
  ベルリン、ドイツ
- Data Source
  KAKENHI-PROJECT-25293170

1. Nakamura Tetsuya (70265809)

# of Collaborated Projects: 2 results

# of Collaborated Products: 69 results
2. NAGAHORI Masakazu (60420254)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. NAGAISHI takashi (60447464)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. ARAKI Akihiro (80361690)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
5. WATANABE Mamoru (10175127)

# of Collaborated Projects: 1 results

# of Collaborated Products: 34 results
6. UEDA Minoru (60265931)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Tsuchiya Kiichiro (40376786)

# of Collaborated Projects: 1 results

# of Collaborated Products: 46 results
8. 入江一浩 (00168535)

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9. 渡邉秀典 (00202416)

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10. 品田哲郎 (30271513)

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11. 小林資正 (40116033)

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12. 叶直樹 (40317293)

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13. 松永茂樹 (60183951)

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14. 井本正哉 (60213253)

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15. 半田宏 (80107432)

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16. 渡辺肇 (80212322)

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17. 佐々木誠 (80235267)

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18. 木越英夫 (90169839)

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19. 西川俊夫 (90208158)

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20. 石橋正己 (90212927)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
21. 油井史郎 (00383886)

# of Collaborated Projects: 1 results

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22. NAKADA Shinichiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. HINOHARA Kunihiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. SUZUKI Shinji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. ASAHINA Yasuhiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
26. YAMAGUCHI Tomoyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. CHEN Cheng-hsin

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
28. TOTSUKA Teruji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. YAMAZAKI Motomi

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
30. ONIZAWA Michio

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
31. SUZUKI Masahiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
32. WATABE Taro

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
33. TANIMIZU Naoki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 永石宇治

# of Collaborated Projects: 0 results

# of Collaborated Products: 14 results
35. 大島茂

# of Collaborated Projects: 0 results

# of Collaborated Products: 9 results
36. 水谷知裕

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# of Collaborated Products: 3 results
37. 後藤典子

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# of Collaborated Products: 1 results
38. 岡田英理子

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# of Collaborated Products: 2 results
39. 大塚和朗

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# of Collaborated Products: 4 results
40. 荒井緑

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# of Collaborated Products: 1 results
41. 荒井孝義

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# of Collaborated Products: 1 results
42. 柿沼晴

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# of Collaborated Products: 2 results
43. 紙谷聡英

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44. 井津井康浩

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# of Collaborated Products: 1 results
45. 中川美奈

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46. 金井隆典

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# of Collaborated Products: 2 results
47. 荒瀬尚

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# of Collaborated Products: 1 results
48. 根本泰宏

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# of Collaborated Products: 2 results
49. 坂本直哉

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# of Collaborated Products: 2 results
50. 藤井俊光

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# of Collaborated Products: 1 results
51. 森尾純子(秋山純子)

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# of Collaborated Products: 1 results
52. 大橋一正

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53. 菊池章

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# of Collaborated Products: 1 results
54. 新田沙由梨

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# of Collaborated Products: 1 results
55. 中内啓光

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56. 佐藤俊朗

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OKAMOTO Ryuichi 岡本 隆一

Research Projects

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スフェロイド・デザイニングによる原腸由来臓器作成技術の開発Principal InvestigatorOngoing

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大腸Label-retaining杯細胞の同定・機能解析と炎症粘膜再生への応用Principal InvestigatorOngoing

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Analysis and therapeutic application of intestinal epithelial cell plasticity in inflammatory bowel diseasePrincipal Investigator

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Establishment of enterohormone farm by using cultured human intestinal epithelial cellsPrincipal Investigator

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Development of colitic mucosa repair therapy by the induction of regeneration-specific stem cell niche formationPrincipal Investigator

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Chemical biology using natural products

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Development of a bio-screening method using intestinal epithelial cellsPrincipal Investigator

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Analysis of intestinal mucosal repair by Notch-activated stem cellsPrincipal Investigator

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Novel therapeutic strategy for ulcerative colitis by targeting NKT cells

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Analysis of Notch-mediated regeneration of the intestinal epitheliaPrincipal Investigator

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Development of mucosa-regenerating therapy through comprehensive analysis of intestine-specific Notch target genesPrincipal Investigator

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[Book] PD-3確定診断困難な多発小腸潰瘍の1例栄養-評価と治療2012

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[Book] 腫瘍をめぐるQ&A(Question45)Lgr5とは?2012

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[Book] Microscopic Colitis(顕微鏡的腸炎)2012

Author(s)

OKAMOTO Ryuichi 岡本隆一