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Oshima Shigeru  大島 茂

ORCIDConnect your ORCID iD *help
… Alternative Names

大島 茂  オオシマ シゲル

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Researcher Number 50376787
Other IDs
Affiliation (Current) 2020: 東京医科歯科大学, 医学部附属病院, 講師
Affiliation (based on the past Project Information) *help 2017 – 2019: 東京医科歯科大学, 医学部附属病院, 講師
2015 – 2017: 東京医科歯科大学, 医学部附属病院, 助教
2013 – 2014: 東京医科歯科大学, 医歯(薬)学総合研究科, 助教
2006: 医科歯科大, 医学部附属病院
2005: 東京医科歯科大学, 医学部附属病院, 医員
Review Section/Research Field
Principal Investigator
Gastroenterology / Basic Section 53010:Gastroenterology-related
Except Principal Investigator
Gastroenterology / Basic Section 53010:Gastroenterology-related
Keywords
Principal Investigator
オートファジー / 炎症性腸疾患 / クローン病 / ユビキチン / IL-7 recepter / IL-7 / CD45RBhigh / TCRa- / - / STAT5 … More / 粘膜内Tリンパ球 / 自己抗体 / リンパ球 / 炎症 / ネクロプトーシス / 腸炎 / 生命金属 / 肉芽腫 … More
Except Principal Investigator
Notch / 慢性大腸炎 / 大腸上皮再生 / 幹細胞 / Notchシグナル / 腸管分化 / 転写因子 / Chronic colitis / Regeneration / Stem Cell / Atoh1 / 炎症発癌 / 自然免疫応答 / 持続炎症刺激モデル / 持続炎症 / 炎症性腸疾患 / シグナルスパイラル / ヒトiPS細胞 / 胆管癌 / 疾患モデル / 胆管上皮細胞 / iPS細胞 / 胆汁 / 発癌機序 Less
  • Research Projects

    (7 results)
  • Research Products

    (46 results)
  • Co-Researchers

    (16 People)
  •  ヒトiPS細胞由来胆管細胞培養系を用いた胆管癌における新規発癌機序の解明Ongoing

    • Principal Investigator
      小林 正典
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Tokyo Medical and Dental University
  •  分子応答解析に基づく肉芽腫形成モデルの樹立Principal InvestigatorOngoing

    • Principal Investigator
      大島 茂
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Tokyo Medical and Dental University
  •  Analysis of negative regulator of necroptosisPrincipal Investigator

    • Principal Investigator
      OSHIMA Shigeru
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Inflammation related carcinogenesis by spiral cell transformation using in vitro chronic colitis model

    • Principal Investigator
      TSUCHIYA Kiichiro
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  The mechanism of autoantibody production in IBDPrincipal Investigator

    • Principal Investigator
      Oshima Shigeru
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  慢性大腸炎粘膜局所T細胞の特異的増殖機構解明と新規治療法開発Principal Investigator

    • Principal Investigator
      大島 茂
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Identification of the Notch signal in intestinal epithelial cells and the failure of the intestinal differentiation in chronic colitis.

    • Principal Investigator
      OKADA Eriko
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University

All 2020 2019 2018 2017 2016 2015 2013

All Journal Article Presentation

  • [Journal Article] TGF-β promotes fetal gene expression and cell migration velocity in a wound repair model of untransformed intestinal epithelial cells2020

    • Author(s)
      Anzai Sho、Kawamoto Ami、Nagata Sayaka、Takahashi Junichi、Kawai Mao、Kuno Reiko、Kobayashi Sakurako、Watanabe Satoshi、Suzuki Kohei、Shimizu Hiromichi、Hiraguri Yui、Takeoka Sayaka、Sugihara Hady Yuki、Yui Shiro、Oshima Shigeru、Watanabe Mamoru、Okamoto Ryuichi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 524 Pages: 533-541

    • DOI

      10.1016/j.bbrc.2020.01.108

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-19H01050
  • [Journal Article] High-fat diet-derived free fatty acids impair the intestinal immune system and increase sensitivity to intestinal epithelial damage.2020

    • Author(s)
      Tanaka Shohei、Nemoto Yasuhiro、Takei Yuria、Morikawa Ryo、Oshima Shigeru、Nagaishi Takashi、Okamoto Ryuichi、Tsuchiya Kiichiro、Nakamura Tetsuya、Stutte Susanne、Watanabe Mamoru
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 522 Pages: 971-977

    • DOI

      10.1016/j.bbrc.2019.11.158

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-19K08364, KAKENHI-PROJECT-19K08388, KAKENHI-PROJECT-19K08438, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-18H02791, KAKENHI-PROJECT-19H03634, KAKENHI-PROJECT-17K09372, KAKENHI-PROJECT-18K19535
  • [Journal Article] T cells show amoeboid shape and frequent morphological change in vitro, and localize to small intestinal intraepithelial region in vivo.2020

    • Author(s)
      Takei Yuria、Nemoto Yasuhiro、Morikawa Ryo、Tanaka Shohei、Oshima Shigeru、Nagaishi Takashi、Okamoto Ryuichi、Tsuchiya Kiichiro、Nakamura Tetsuya、Watanabe Mamoru
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 523 Pages: 328-335

    • DOI

      10.1016/j.bbrc.2019.12.021

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-19K08364, KAKENHI-PROJECT-19K08388, KAKENHI-PROJECT-19K08438, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-18H02791, KAKENHI-PROJECT-19H03634, KAKENHI-PROJECT-17K09372, KAKENHI-PROJECT-18K19535
  • [Journal Article] Receotir-Interacting Protein Kinase3(RIPK3)inhibits autophagic flux furing necroptosis in intestinal epithelial cells.2020

    • Author(s)
      Otsubo K, Maeyashiki C, Nibe Y, Tamura A, Aonuma E, Matsuda H, Kobayashi M, Onizawa M, Nemoto Y, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Torii S, Itakura E, Watanabe M, Oshima S.
    • Journal Title

      FEBS Lett.

      Volume: 594 Pages: 1586-1595

    • DOI

      10.1002/1873-3468.13748

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06210, KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-19K08364, KAKENHI-PROJECT-19K08388, KAKENHI-PROJECT-19K08438, KAKENHI-PROJECT-19K22413, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-16H06167, KAKENHI-PROJECT-17K09372
  • [Journal Article] Ubiquitin D is up-regulated by synergy of Notch signaling and TNF-α in the inflamed intestinal epithelia of IBD patients.2019

    • Author(s)
      Kawamoto Ami、Nagata Sayaka、Anzai Sho、Takahashi Junichi、Kawai Mao、Hama Minami、Nogawa Daichi、Yamamoto Kouhei、Kuno Reiko、Suzuki Kohei、Shimizu Hiromichi、Hiraguri Yui、Yui Shiro、Oshima Shigeru、Tsuchiya Kiichiro、Nakamura Tetsuya、Ohtsuka Kazuo、Kitagawa Masanobu、Okamoto Ryuichi、Watanabe Mamoru
    • Journal Title

      J Crohns Colitis

      Volume: 13 Pages: 495-509

    • DOI

      10.1093/ecco-jcc/jjy180

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09370, KAKENHI-PROJECT-18K07902, KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-17K19675, KAKENHI-PROJECT-18K19535, KAKENHI-PROJECT-18K15743, KAKENHI-PROJECT-18K15774, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-16H05284, KAKENHI-PROJECT-17H04024, KAKENHI-PROJECT-18H02867, KAKENHI-PROJECT-17K19513, KAKENHI-PROJECT-17K19674, KAKENHI-PROJECT-18H02791
  • [Journal Article] Genetic and environmental factors drive personalized medicine for Crohn’s disease.2019

    • Author(s)
      Oshima Shigeru、Watanabe Mamoru
    • Journal Title

      J Clin Invest.

      Volume: 128 Pages: 4758-4760

    • DOI

      10.1172/jci124303

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-17K19675, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-17H04024, KAKENHI-PROJECT-17K19513
  • [Journal Article] Contribution of ATOH1+ cells to the homeostasis, repair and tumorigenesis of the colonic epithelium.2018

    • Author(s)
      Ishibashi Fumiaki、Shimizu Hiromichi、Nakata Toru、Fujii Satoru、Suzuki Kohei、Kawamoto Ami、Anzai Sho、Kuno Reiko、Nagata Sayaka、Ito Go、Murano Tatsuro、Mizutani Tomohiro、Oshima Shigeru、Tsuchiya Kiichiro、Nakamura Tetsuya、Watanabe Mamoru、Okamoto Ryuichi
    • Journal Title

      Stem Cell Rep.

      Volume: 10 Pages: 27-42

    • DOI

      10.1016/j.stemcr.2017.11.006

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K19674, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H05284, KAKENHI-PROJECT-17K19675, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-17H04024, KAKENHI-PROJECT-17K19513
  • [Journal Article] Novel polyubiquitin imaging system, PolyUb-FC, reveals that K33-linked polyubiquitin is recruited by SQSTM1/p62.2018

    • Author(s)
      Yoichi Nibe, Shigeru Oshima, Masanori Kobayashi, Chiaki Maeyashiki, Yu Matsuzawa, Kana Otsubo, Hiroki Matsuda, Emi Aonuma, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Shinichiro Nakada, Mamoru Watanabe
    • Journal Title

      Autophagy

      Volume: 22 Pages: 347-358

    • DOI

      10.1080/15548627.2017.1407889

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09372, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H05284, KAKENHI-PROJECT-16H05286, KAKENHI-PROJECT-16K15423, KAKENHI-PROJECT-17K19675, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-17H04024, KAKENHI-PROJECT-17K19513, KAKENHI-PROJECT-26241014
  • [Journal Article] Data showing proliferation and differentiation of intestinal epithelial cells under targeted depletion of Notch ligands in mouse intestine.2017

    • Author(s)
      Nakata T, Shimizu H, Nagata S, Ito G, Fujii S, Suzuki K, Kawamoto A, Ishibashi F, Kuno R, Anzai S, Murano T, Mizutani T, Oshima S, Tsuchiya K, Nakamura T, Hozumi K, Watanabe M, Okamoto R
    • Journal Title

      Data in Brief

      Volume: 10 Pages: 551-556

    • DOI

      10.1016/j.dib.2016.12.045

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H05284
  • [Journal Article] HADHA, the alpha subunit of the mitochondrial trifunctional protein, is involved in long-chain fatty acid-induced autophagy in intestinal epithelial cells.2017

    • Author(s)
      Maeyashiki C, Oshima S, Otsubo K, Kobayashi M, Nibe Y, Matsuzawa Y, Onizawa M, Nemoto Y, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Watanabe M
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 484 Pages: 636-641

    • DOI

      10.1016/j.bbrc.2017.01.159

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H05286, KAKENHI-PROJECT-16H06771, KAKENHI-PROJECT-15K15288, KAKENHI-PROJECT-16K15423
  • [Journal Article] Long-term Inflammation Transforms Intestinal Epithelial Cells of Colonic Organoids2017

    • Author(s)
      Hibiya S, Tsuchiya K, Hayashi R, Horita N, Watanabe S, Shirasaki T, Nishimura R, Kimura N, Nishimura T, Gotoh N, Oshima S, Okamoto R, Nakamura T, Watanabe M
    • Journal Title

      Journal of Crohn's and Colitis

      Volume: 61 Pages: 621-630

    • DOI

      10.1093/ecco-jcc/jjw186

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H06770, KAKENHI-PROJECT-15K15287, KAKENHI-PROJECT-17K15930, KAKENHI-PROJECT-17H06654, KAKENHI-PROJECT-16K09302
  • [Journal Article] Indispensable role of Notch ligand-dependent signaling in the proliferation and stem cell niche maintenance of APC-deficient intestinal tumors.2017

    • Author(s)
      Nakata T, Shimizu H, Nagata S, Ito G, Fujii S, Suzuki K, Kawamoto A, Ishibashi F, Kuno R, Anzai S, Murano T, Mizutani T, Oshima S, Tsuchiya K, Nakamura T, Hozumi K, Watanabe M, Okamoto R
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 482 Pages: 1296-1303

    • DOI

      10.1016/j.bbrc.2016.12.031

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H05284
  • [Journal Article] The ubiquitin hybrid gene UBA52 regulates ubiquitination of ribosome and sustains embryonic development.2016

    • Author(s)
      Kobayashi M, Oshima S, Maeyashiki C, Nibe Y, Otsubo K, Matsuzawa Y, Memoto Y, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Watanabe M
    • Journal Title

      Sci Rep

      Volume: 6 Pages: 36780-36780

    • DOI

      10.1038/srep36780

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H05286, KAKENHI-PROJECT-26460963, KAKENHI-PROJECT-15K15288
  • [Journal Article] PGE2 is a direct and robust mediator of anion/fluid secretion by human intestinal epithelial cells2016

    • Author(s)
      Fujii S, Okamoto R, Suzuki K, Kawamoto A, Ishibashi F, Nakata T, Murano T, Ito G, Shimizu H, Mizutani T, Oshima S, Tsuchiya K, Nakamura T, Araki A, Ohtsuka K, Watanabe M
    • Journal Title

      Sci Rep

      Volume: 6 Pages: 36795-36795

    • DOI

      10.1038/srep36795

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-15K15286, KAKENHI-PROJECT-16K09302
  • [Journal Article] TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy.2015

    • Author(s)
      Matsuzawa Y, Oshima S, Takahara M, Maeyashiki C, Nemoto Y, Kobayashi M, Nibe Y, Nozaki K, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Averil Ma, Watanabe M
    • Journal Title

      Autophagy

      Volume: 11 Pages: 1052-1062

    • DOI

      10.1080/15548627.2015.1055439

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460963, KAKENHI-PROJECT-15K15286, KAKENHI-PROJECT-15K15288, KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-25460946, KAKENHI-PROJECT-25293170
  • [Journal Article] Atonal homolog 1 protein stabilized by tumor necrosis factor α induces high malignant potential in colon cancer cell line.2015

    • Author(s)
      Keita Fukushima, Kiichiro Tsuchiya,Okamoto Ryuichi, Mamoru Watanabe,et al
    • Journal Title

      Cancer Sci.

      Volume: 106 Pages: 1000-1007

    • DOI

      10.1111/cas.12703

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K15286, KAKENHI-PROJECT-15K15287, KAKENHI-PROJECT-15K15288, KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-25293170
  • [Journal Article] The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis.2015

    • Author(s)
      Onizawa M, Oshima S, Schulze-Topphoff U, Oses-Prieto JA, Lu T, Tavares R, Prodhomme T, Duong B, Whang MI, Advincula R, Agelidis A, Barrera J, Wu H, Burlingame A, Malynn BA, Zamvil SS, Ma A.
    • Journal Title

      Nat Immunol

      Volume: 16 Pages: 618-27

    • DOI

      10.1038/ni.3172

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25460946
  • [Journal Article] RIPK3 regulates p62- LC3 complex formation via the caspase-8-dependent cleavage of p622015

    • Author(s)
      Y. Matsuzawa , S. Oshima, Y. Nibe, M.Kobayashi, C. Maeyashiki, Y. Nemoto, T. Nagaishi, R. Okamoto R, K. Tsuchiya, T. Nakamura, M. Watanabe.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 456(1) Pages: 298-304

    • DOI

      10.1016/j.bbrc.2014.11.075

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-24590935, KAKENHI-PROJECT-24590936, KAKENHI-PROJECT-24590937, KAKENHI-PUBLICLY-25114703, KAKENHI-PUBLICLY-25130704, KAKENHI-PROJECT-25293170, KAKENHI-PROJECT-25460946, KAKENHI-PROJECT-26460963, KAKENHI-PROJECT-26221307
  • [Journal Article] ABIN-1 protects against psoriasis by restricting MyD88 signals in dendritic cells.2013

    • Author(s)
      Callahan JA1, Hammer GE, Agelides A, Duong BH, Oshima S, North J, Advincula R, Shifrin N, Truong HA, Paw J, Barrera J, DeFranco A, Rosenblum MD, Malynn BA, Ma A.
    • Journal Title

      J Immunol.

      Volume: 191 Pages: 535-9

    • DOI

      10.4049/jimmunol.1203335

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25460946
  • [Journal Article] A20 restricts wnt signaling in intestinal epithelial cells and suppresses colon carcinogenesis.2013

    • Author(s)
      Shao L, Oshima S, Duong B, Advincula R, Barrera J, Malynn BA, Ma A.
    • Journal Title

      PLoS One

      Volume: 8

    • DOI

      10.1371/journal.pone.0062223

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25460946
  • [Presentation] K33-linked polyubiquitin is recruited by SQSTM1/p622019

    • Author(s)
      Shigeru Oshima, Yoichi Nibe, Akiko Tamura, Hiroki Matsuda, Emi Aonuma, Kana Otsubo, and Mamoru Watanabe.
    • Organizer
      Keystone Symposia: Autophagy(B2)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07934
  • [Presentation] The role of ubiquitination in crosstalk of intestinal epithelial cell death and autophagic signaling was revealed by a novel polyubiquitin imaging system2019

    • Author(s)
      Kana Otsubo, Yoichi Nibe, Chiaki Maeyashiki, Akiko Tamura, Emi Aonuma, Hiroki Matsuda, Mamoru Watanabe, Shigeru Oshima
    • Organizer
      19th International congress of mucosal immunology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07934
  • [Presentation] ユビキチンコード遺伝子の大腸腫瘍における役割2019

    • Author(s)
      大島 茂、小林正典、田村皓子、松田浩紀、青沼映美、大坪加奈、仁部洋一、渡辺 守
    • Organizer
      第56回日本消化器免疫学会
    • Data Source
      KAKENHI-PROJECT-18K07934
  • [Presentation] K33鎖ユビキチン鎖の機能解析2019

    • Author(s)
      大島 茂
    • Organizer
      新学術領域研究「ネオユビキチン」 令和元年度 第3回領域班会議
    • Data Source
      KAKENHI-PROJECT-18K07934
  • [Presentation] 非定型ユビキチン鎖の機能解明2019

    • Author(s)
      大島 茂
    • Organizer
      第1回新学術「ケモユビキチン」班会議・第2回ユビキチン研究会合同会議
    • Data Source
      KAKENHI-PROJECT-18K07934
  • [Presentation] Long-chain fatty acid regulates autophagy and polyubiquitination in intestinal epithelial cells2018

    • Author(s)
      Kana Otsubo, Chiaki Maeyashiki, Emi Aonuma, Hiroki Matsuda, Yoichi Nibe, Masanori Kobayashi, Yu Matsuzawa, Mamoru Watanabe, Shigeru Oshima
    • Organizer
      Keystone Symposia - Ubiquitin Signaling
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04808
  • [Presentation] K33-linked polyubiquitin is recruited by SQSTM1/p622018

    • Author(s)
      Hiroki Matsuda, Yoichi Nibe, Emi Aonuma, Kana Otsubo, Chiaki Maeyashiki, Masanori Kobayashi, Yu Matsuzawa, Shinichiro Nakada, Mamoru Watanabe and Shigeru Oshima
    • Organizer
      Keystone Symposia - Ubiquitin Signaling
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04808
  • [Presentation] 免疫疾患制御を目標としたユビキチン鎖可視化技術(PolyUb-FC)の開発2018

    • Author(s)
      大島 茂、仁部洋一、田村皓子、青沼映美、松田浩紀、大坪加奈、鬼澤道夫、渡辺 守
    • Organizer
      第46回日本臨床免疫学会総会
    • Data Source
      KAKENHI-PROJECT-18K07934
  • [Presentation] Necroptosis stimulation regulates SQSTM1/p62-LC3 complex formation and polyubiquitination2018

    • Author(s)
      Emi Aonuma, Yoichi Nibe, Hiroki Matsuda, Kana Otsubo, Chiaki Maeyashiki, Masanori Kobayashi, Yu Matsuzawa, Mamoru Watanabe, Shigeru Oshima
    • Organizer
      Keystone Symposia - Ubiquitin Signaling
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04808
  • [Presentation] Novel polyubiquitin imaging system, PolyUb-FC, visualized atypical polyubiquitin chain in living cells2018

    • Author(s)
      Nibe Y, Matsuda H, Aonuma E, Otsubo K, Maeyashiki C, Kobayashi M, Matsuzawa Y, Nakada S, Watanabe M, and Oshima S
    • Organizer
      Keystone Symposia - Ubiquitin Signaling (A8)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K15423
  • [Presentation] Necroptosis stimulation regulates SQSTM1/p62-LC3 complex formation and polyubiquitination.2018

    • Author(s)
      Aonuma E, Nibe Y, Matsuda H, Otsubo K, Maeyashiki C, Kobayashi M, Matsuzawa Y, Watanabe M, and Oshima S
    • Organizer
      Keystone Symposia - Ubiquitin Signaling (A8)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K15423
  • [Presentation] Novel polyubiquitin imaging system, PolyUb-FC, visualized atypical polyubiquitin chain in living cells2018

    • Author(s)
      Yoichi Nibe, Hiroki Matsuda, Emi Aonuma, Kana Otsubo, Chiaki Maeyashiki, Masanori Kobayashi, Yu Matsuzawa, Shinichiro Nakada, Mamoru Watanabe, Shigeru Oshima
    • Organizer
      Keystone Symposia - Ubiquitin Signaling
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04808
  • [Presentation] 独自ポリユビキチン鎖可視化技術を用いた新規腸炎調節分子の同定2018

    • Author(s)
      大島 茂、仁部洋一、松田浩紀、田村皓子、青沼映美、大坪加奈、渡辺 守
    • Organizer
      第55回日本消化器免疫学会総会
    • Data Source
      KAKENHI-PROJECT-18K07934
  • [Presentation] Novel polyubiquitin imaging reveals that atypical polyubiquitin contribute to autophagy via p622017

    • Author(s)
      Nibe Y, Oshima S, Aonuma E, Matsuda H, Otsubo K, Maeyashiki C, Kobayashi M, Matsuzawa Y, Nakada S, Watanabe M.
    • Organizer
      The 8th International Symposium on Autophagy
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K15423
  • [Presentation] TP53 mutation acquires higher malignant potential in human colon cancer cells2017

    • Author(s)
      Watanabe S, Tsuchiya K, Shirasaki T, Hibiya S, Oshima S, Nakamura T, Nishimura R, Okamoto R, Watanabe M.
    • Organizer
      UEGW2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04808
  • [Presentation] Novel polyubiquitin imaging reveals that atypical polyubiquitin contribute to autophagy2017

    • Author(s)
      Nibe Y, Oshima S, Aonuma E, Matsuda H, Otsubo K, Maeyashiki C, Kobayashia M, Matsuzawa Y , Nakada S, Watanabe M.
    • Organizer
      GI research Academy
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K15423
  • [Presentation] HADHA, the alpha subunit of the mitochondrial trifunctional protein, is involved in long-chain fatty acid-induced autophagy in intestinal epithelial cells.2017

    • Author(s)
      Otsubo K, Oshima S, Maeyashiki C, Aonuma E, Matsuda H, Kobayashi M, Nibe Y, Matsuzawa Y, Watanabe M
    • Organizer
      The 8th International Symposium on Autophagy
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K15423
  • [Presentation] Atoh1 protein stabilization in colon tumor acquires the morphological change to signet ring cell carcinoma with cancer stem cell enrichment.2016

    • Author(s)
      Tsuchiya K, Hibiya S, Fukushima K, Shirasaki T, Oshima S, Okamoto R, Nakamura T, Watanabe M.
    • Organizer
      APDW2016
    • Place of Presentation
      Kobe convention center, KOBE(JAPAN)
    • Year and Date
      2016-11-03
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04808
  • [Presentation] Construction of in vitro model of ulcerative colitis using mouse primary colonic organoid.2016

    • Author(s)
      Hibiya S, Tsuchiya K, Watanabe S, Shirasaki T, Oshima S, Okamoto R, Nakamura T, Watanabe M.
    • Organizer
      UEGW2016
    • Place of Presentation
      Vienna(Austria)
    • Year and Date
      2016-10-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04808
  • [Presentation] Mouse colonic organoid acquires wnt-independent survival property after long-term inflammation.2016

    • Author(s)
      Shuji Hibiya, Kiichiro Tsuchiya, Tomoaki Shirasaki, Keita Fukushima, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe.
    • Organizer
      AOCC2016
    • Place of Presentation
      Kyoto International Conference Center, Kyoto(JAPAN)
    • Year and Date
      2016-07-08
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04808
  • [Presentation] Atoh1 protein stabilization in colon tumor acquires the phenotype of signet ring cell carcinoma with cancer stem cell enrichment.2016

    • Author(s)
      Kiichiro Tsuchiya, Shuji Hibiya, Keita Fukushima, Tomoaki Shirasaki, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe.
    • Organizer
      AOCC2016
    • Place of Presentation
      Kyoto International Conference Center, Kyoto(JAPAN)
    • Year and Date
      2016-07-08
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04808
  • [Presentation] 長期炎症刺激による大腸上皮培養細胞の非可逆的NF κB シグナル活性.2016

    • Author(s)
      日比谷秀爾、土屋輝一郎、白崎友彬、福島啓太、大島 茂、岡本隆一、中村哲也、渡辺 守.
    • Organizer
      第102回日本消化器病学会総会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2016-04-21
    • Data Source
      KAKENHI-PROJECT-15H04808
  • [Presentation] UBA52, ubiquitin hybrid ribisomal protein, regulates NF-κB signaling in colon cancer.2016

    • Author(s)
      Masanori Kobayashi, Shigeru Oshima, Yoishi Nibe, Chiaki Maeyashiki, Mamoru Watanabe.
    • Organizer
      DDW2016
    • Place of Presentation
      San Diego(USA)
    • Year and Date
      2016-05-21
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04808
  • [Presentation] Indentification of autophagic regulators as therapeutic targets in intestinal epithelial cells.2016

    • Author(s)
      Chiaki Maeyashiki, Shigeru Oshima, Yoishi Nibe, Masanori Kobayashi, Mamoru Watanabe.
    • Organizer
      DDW
    • Place of Presentation
      San Diego (USA)
    • Year and Date
      2016-05-23
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K15423
  • [Presentation] Construction of in vitro model for inflammatory bowel disease using primary colonic organoid.2016

    • Author(s)
      Syuji Hibiya, Kiichiro Tsuchiya, Tomoaki Shirasaki, Keita Fukushima, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe.
    • Organizer
      DDW2016
    • Place of Presentation
      San Diego(USA)
    • Year and Date
      2016-05-21
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04808
  • [Presentation] A Crohn's Disease Susceptibility Gene A20 Regulates Autophagy Dynamics in CD4 T Cells2015

    • Author(s)
      Yu Matsuzawa, Shigeru Oshima, Masanori Kobayashi, Yoichi Nibe, Chiaki Maeyashiki, Averil I. Ma, Mamoru Watanabe
    • Organizer
      DDW(Digestive Disease Week)
    • Place of Presentation
      Washington, DC(USA)
    • Year and Date
      2015-05-16
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25460946
  • 1.  WATANABE Mamoru (10175127)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 30 results
  • 2.  TSUCHIYA Kiichiro (40376786)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 22 results
  • 3.  OKADA Eriko (20376784)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  KUBOTA Daisuke (00376790)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  小林 正典 (10825459)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  柿沼 晴 (30372444)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  ONIZAWA Michio
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 8.  OKAMOTO Ryuichi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 11 results
  • 9.  ARAKI Akihiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  NAKADA Shinichiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  TORII Satoru
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  中村 哲也
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 12 results
  • 13.  永石 宇治
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 9 results
  • 14.  大塚 和朗
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 15.  西村 龍
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 16.  日比谷 秀爾
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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