Oshima Shigeru 大島茂

… Alternative Names

大島茂オオシマシゲル

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Researcher Number	50376787
Other IDs
Affiliation (Current)	2025: 東京科学大学, 戦略本部, 教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 東京医科歯科大学, 統合研究機構, 教授 2017 – 2021: 東京医科歯科大学, 医学部附属病院, 講師 2015 – 2017: 東京医科歯科大学, 医学部附属病院, 助教 2013 – 2014: 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 2006: 医科歯科大, 医学部附属病院 2005: 東京医科歯科大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related Except Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related
Keywords	Principal Investigator オートファジー / ユビキチン / クローン病 / 炎症性腸疾患 / 腸炎 / 生命金属 / ニッケル / TNFAIP3/A20 / TNFAIP3 / A20 … More / p62/SQSTM! / LC3 / p62 / 肉芽腫 / ネクロプトーシス / 炎症 / リンパ球 / 自己抗体 / 粘膜内Tリンパ球 / STAT5 / - / TCRa- / CD45RBhigh / IL-7 / IL-7 recepter … More Except Principal Investigator Notch / 発癌機序 / 胆汁 / iPS細胞 / 胆管上皮細胞 / 疾患モデル / 胆管癌 / ヒトiPS細胞 / シグナルスパイラル / 炎症性腸疾患 / 持続炎症 / 持続炎症刺激モデル / 自然免疫応答 / 炎症発癌 / Atoh1 / Stem Cell / Regeneration / Chronic colitis / 転写因子 / 腸管分化 / Notchシグナル / 幹細胞 / 大腸上皮再生 / 慢性大腸炎 Less

the role of biometal in the intestinal environmentPrincipal Investigator
- Principal Investigator
  
  Oshima Shigeru
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokyo Medical and Dental University
Analysis of a novel molecular mechanism in bile duct carcinoma using a human iPS cell-derived cholangiocyte culture system
- Principal Investigator
  
  Kobayashi Masanori
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokyo Medical and Dental University
Establishment of granuloma formation model based on molecular response analysisPrincipal Investigator
- Principal Investigator
  
  Oshima Shigeru
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokyo Medical and Dental University
Analysis of negative regulator of necroptosisPrincipal Investigator
- Principal Investigator
  
  OSHIMA Shigeru
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
Inflammation related carcinogenesis by spiral cell transformation using in vitro chronic colitis model
- Principal Investigator
  
  TSUCHIYA Kiichiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
The mechanism of autoantibody production in IBDPrincipal Investigator
- Principal Investigator
  
  Oshima Shigeru
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
慢性大腸炎粘膜局所T細胞の特異的増殖機構解明と新規治療法開発Principal Investigator
- Principal Investigator
  
  大島茂
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
Identification of the Notch signal in intestinal epithelial cells and the failure of the intestinal differentiation in chronic colitis.
- Principal Investigator
  
  OKADA Eriko
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013

All Journal Article Presentation

[Journal Article] Single cell analysis revealed that two distinct, unique CD4+ T cell subsets were increased in the small intestinal intraepithelial lymphocytes of aged mice.2024
- Author(s)
  Yuki Yonemoto, Yasuhiro Nemoto, Ryo Morikawa, Nana Shibayama, Shigeru Oshima, Takashi Nagaishi, Tomohiro Mizutani, Go Ito, Satoru Fujii, Ryuichi Okamoto.
- Journal Title
  
  Frontiers in Immunology.
  
  Volume: 15 Pages: 1340048-1340048
- DOI
  10.3389/fimmu.2024.1340048
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07978, KAKENHI-PROJECT-23K07394, KAKENHI-PROJECT-23K07413, KAKENHI-PROJECT-21KK0146, KAKENHI-PROJECT-21H02897, KAKENHI-PROJECT-23K27579
[Journal Article] Apelin expression is downregulated in T cells in a murine model of chronic colitis2023
- Author(s)
  Yamada D、Kojima Yi、Hosoya A、Suzuki、Watabe T、Inoue T、Tsugawa N、Asakawa T、Yonemoto Y、Onizawa M、Nemoto Y、Oshima S、Shimonaka M、Kuba Ki、Ishida J、Fukamizu A、Penninger JM、Watanabe M、Okamoto R、Nagaishi T
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 647 Pages: 72-79
- DOI
  10.1016/j.bbrc.2023.01.068
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05986, KAKENHI-PROJECT-22K07978, KAKENHI-PROJECT-22K19551, KAKENHI-PROJECT-22H00472, KAKENHI-PROJECT-20H03426, KAKENHI-PROJECT-20H03658, KAKENHI-PROJECT-21H02897, KAKENHI-PROJECT-20K08304
[Journal Article] Novel-time resolved reporter mouse reveals spatial and transcriptional heterogeneity during alpha cell differentiation2023
- Author(s)
  Himuro M, Wakabayashi Y, Taguchi T, Katahira T, Suzuki L, Iida H, Ogihara T, Nishida Y, Sasaki S, Lynn FC, Hiraoka Y, Oshima S, Okamoto R, Fujitani Y, Watada H, Miyatsuka T
- Journal Title
  
  Diabetologia
  
  Volume: 67 Issue: 1 Pages: 156-169
- DOI
  10.1007/s00125-023-06028-w
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19421, KAKENHI-PROJECT-21H02897
[Journal Article] Zranb1-mutant mice display abnormal colonic mucus production and exacerbation of DSS-induced colitis.2022
- Author(s)
  Tamura A, Ito G, Matsuda H, Nibe-Shirakihara Y, Hiraoka Y, Kitagawa S, Hiraguri Y, Nagata S, Aonuma E, Otsubo K, Nemoto Y, Nagaishi T, Watanabe M, Okamoto R, Oshima S.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 628 Pages: 147-154
- DOI
  10.1016/j.bbrc.2022.08.046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07978, KAKENHI-PROJECT-21KK0146, KAKENHI-PROJECT-22H00465, KAKENHI-PROJECT-22H00472, KAKENHI-PROJECT-20H03658, KAKENHI-PROJECT-21H02897, KAKENHI-PROJECT-20K08304, KAKENHI-PROJECT-21K15968
[Journal Article] Nickel particles are present in Crohn's disease tissue and exacerbate intestinal inflammation in IBD susceptible mice.2022
- Author(s)
  Hiroki Matsuda, Yoichi Nibe-Shirakihara, Akiko Tamura, Emi Aonuma, Satoko Arakawa, Kana Otsubo, Yasuhiro Nemoto, Takashi Nagaishi, Kiichiro Tsuchiya, Shigeomi Shimizu, Averil Ma, Mamoru Watanabe, Motohiro Uo, Ryuichi Okamoto, Shigeru Oshima.
- Journal Title
  
  Biochemical and Biophysical Research Communications.
  
  Volume: 592 Pages: 74-80
- DOI
  10.1016/j.bbrc.2021.12.111
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08364, KAKENHI-PROJECT-19K08388, KAKENHI-PROJECT-19K08438, KAKENHI-PROJECT-20K21597, KAKENHI-PROJECT-20H00467, KAKENHI-PLANNED-17H06414, KAKENHI-PUBLICLY-20H05314, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-19H03634, KAKENHI-PROJECT-20H03658, KAKENHI-PROJECT-21H02897, KAKENHI-PROJECT-21H02898, KAKENHI-PROJECT-20K08304, KAKENHI-PUBLICLY-21H05743, KAKENHI-PROJECT-22H00472, KAKENHI-PROJECT-20K07353, KAKENHI-PROJECT-21K15968, KAKENHI-WRAPUP-22H04899, KAKENHI-PUBLICLY-22H04639
[Journal Article] Oral administration of D-serine prevents the onset and progression of colitis in mice.2021
- Author(s)
  Takehito Asakawa, Michio Onizawa, Chikako Saito, Rie Hikichi, Daiki Yamada, Ai Minamidate, Tomoaki Mochimaru, Shun-ichiro Asahara, Yoshiaki Kido, Shigeru Oshima, Takashi Nagaishi, Kiichiro Tsuchiya, Hiromasa Ohira, Ryuichi Okamoto, Mamoru Watanabe.
- Journal Title
  
  Journal of Gastroenterolog.
  
  Volume: 56 Issue: 8 Pages: 732-745
- DOI
  10.1007/s00535-021-01792-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08364, KAKENHI-PROJECT-19K08388, KAKENHI-PROJECT-19K08438, KAKENHI-PROJECT-19K08461, KAKENHI-PROJECT-20K21597, KAKENHI-PROJECT-18KK0438, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-20H03658, KAKENHI-PROJECT-21H02897, KAKENHI-PROJECT-21H02898, KAKENHI-PROJECT-20K08304, KAKENHI-PROJECT-20K08860, KAKENHI-PROJECT-21K08579
[Journal Article] Intraepithelial Lymphocytes Suppress Intestinal Tumor Growth by Cell-to-Cell Contact via CD103/E-Cadherin Signal.2021
- Author(s)
  Ryo Morikawa, Yasuhiro Nemoto, Yuki Yonemoto, Shohei Tanaka, Yuria Takei, Shigeru Oshima, Takashi Nagaishi, Kiichiro Tsuchiya, Kengo Nozaki , Tomohiro Mizutani, Tetsuya Nakamura, Mamoru Watanabe, Ryuichi Okamoto.
- Journal Title
  
  Cell Mol Gastroenterol Hepatol.
  
  Volume: 11 Issue: 5 Pages: 1483-1503
- DOI
  10.1016/j.jcmgh.2021.01.014
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08364, KAKENHI-PROJECT-19K08388, KAKENHI-PROJECT-19K08438, KAKENHI-PROJECT-20K08304, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-18H02790, KAKENHI-PROJECT-18H02791, KAKENHI-PROJECT-20H03658, KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-18K07964, KAKENHI-PROJECT-17H04024, KAKENHI-PROJECT-19K08461, KAKENHI-PROJECT-20K22920, KAKENHI-PROJECT-17K19675, KAKENHI-PROJECT-21H02895, KAKENHI-PROJECT-21H02897, KAKENHI-PROJECT-21H02898
[Journal Article] A potent endocytosis inhibitor Ikarugamycin up-regulates TNF production.2021
- Author(s)
  Ai Minamidate, Michio Onizawa, Chikako Saito, Rie Hikichi, Tomoaki Mochimaru, Mai Murakami, Chiharu Sakuma, Takehito Asakawa, Yuichi Hiraoka, Shigeru Oshima, Takashi Nagaishi, Kiichiro Tsuchiya, Hiromasa Ohira, Ryuichi Okamoto, Mamoru Watanabe.
- Journal Title
  
  Biochemistry and Biophysics Reports.
  
  Volume: 27 Pages: 101065-101065
- DOI
  10.1016/j.bbrep.2021.101065
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08364, KAKENHI-PROJECT-19K08388, KAKENHI-PROJECT-19K08438, KAKENHI-PROJECT-20K21597, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-19H03634, KAKENHI-PROJECT-20H03658, KAKENHI-PROJECT-21H02897, KAKENHI-PROJECT-21H02898, KAKENHI-PROJECT-20K08304
[Journal Article] Functional analysis of isoflavones using patient-derived human colonic organoids2021
- Author(s)
  Tsuchiya Mao、Ito Go、Hama Minami、Nagata Sayaka、Kawamoto Ami、Suzuki Kohei、Shimizu Hiromichi、Anzai Sho、Takahashi Junichi、Kuno Reiko、Takeoka Sayaka、Hiraguri Yui、Sugihara Hady Yuki、Mizutani Tomohiro、Yui Shiro、Oshima Shigeru、Tsuchiya Kiichiro、Watanabe Mamoru、Okamoto Ryuichi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 542 Pages: 40-47
- DOI
  10.1016/j.bbrc.2021.01.021
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21597, KAKENHI-PROJECT-20K22895, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-18H02791, KAKENHI-PROJECT-19H03634, KAKENHI-PROJECT-20H03657, KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-19K17484, KAKENHI-PROJECT-19K23990, KAKENHI-PROJECT-20K22920, KAKENHI-PROJECT-21H02895, KAKENHI-PROJECT-21K15992
[Journal Article] Notch and TNF-α signaling promote cytoplasmic accumulation of OLFM4 in intestinal epithelium cells and exhibit a cell protective role in the inflamed mucosa of IBD patients2021
- Author(s)
  Kuno Reiko、Ito Go、Kawamoto Ami、Hiraguri Yui、Sugihara Hady Yuki、Takeoka Sayaka、Nagata Sayaka、Takahashi Junichi、Tsuchiya Mao、Anzai Sho、Mizutani Tomohiro、Shimizu Hiromichi、Yui Shiro、Oshima Shigeru、Tsuchiya Kiichiro、Watanabe Mamoru、Okamoto Ryuichi
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 25 Pages: 100906-100906
- DOI
  10.1016/j.bbrep.2020.100906
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21597, KAKENHI-PROJECT-20K22895, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-18H02791, KAKENHI-PROJECT-19H03634, KAKENHI-PROJECT-20H03657, KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-19K17484, KAKENHI-PROJECT-19K23990, KAKENHI-PROJECT-17H04024, KAKENHI-PROJECT-20K22920, KAKENHI-PROJECT-17K19675, KAKENHI-PROJECT-21H02895, KAKENHI-PROJECT-21K15992
[Journal Article] Receptor-Interacting Protein Kinase 3 (RIPK3) inhibits autophagic flux during necroptosis in intestinal epithelial cells.2020
- Author(s)
  Otsubo K, Maeyashiki C, Nibe Y, Tamura A, Aonuma E, Matsuda H, Kobayashi M, Onizawa M, Nemoto Y, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Torii S, Itakura E, Watanabe M, Oshima S.
- Journal Title
  
  FEBS letters
  
  Volume: 594 Issue: 10 Pages: 1586-1595
- DOI
  10.1002/1873-3468.13748
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06210, KAKENHI-PROJECT-19K08364, KAKENHI-PROJECT-19K22413, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-16H06167, KAKENHI-PROJECT-17K09372, KAKENHI-PROJECT-19K08388, KAKENHI-PROJECT-19K08438, KAKENHI-PROJECT-19K08461, KAKENHI-PROJECT-20K08304, KAKENHI-PROJECT-20H03658, KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-19K17426, KAKENHI-PROJECT-17H04024, KAKENHI-PROJECT-17K19675
[Journal Article] CD8αα+ T cells show amoeboid shape and frequent morphological change in?vitro, and localize to small intestinal intraepithelial region in?vivo2020
- Author(s)
  Takei Yuria、Nemoto Yasuhiro、Morikawa Ryo、Tanaka Shohei、Oshima Shigeru、Nagaishi Takashi、Okamoto Ryuichi、Tsuchiya Kiichiro、Nakamura Tetsuya、Watanabe Mamoru
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 523 Issue: 2 Pages: 328-335
- DOI
  10.1016/j.bbrc.2019.12.021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08364, KAKENHI-PROJECT-19K08388, KAKENHI-PROJECT-19K08438, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-18H02791, KAKENHI-PROJECT-19H03634, KAKENHI-PROJECT-17K09372, KAKENHI-PROJECT-18K19535, KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-17H04024
[Journal Article] Nickel ions attenuate autophagy flux and induce transglutaminase 2 (TG2) mediated post-translational modification of SQSTM1/p62.2020
- Author(s)
  Emi Aonuma, Akiko Tamura, Hiroki Matsuda, Takehito Asakawa, Yuriko Sakamaki, Kana Otsubo, Yoichi Nibe, Michio Onizawa, Yasuhiro Nemoto, Takashi Nagaishi, Kiichiro Tsuchiya, Tetsuya Nakamura, Motohiro Uo, Mamoru Watanabe, Ryuichi Okamoto, Shigeru Oshima.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 542 Pages: 17-23
- DOI
  10.1016/j.bbrc.2021.01.023
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08364, KAKENHI-PROJECT-19K08388, KAKENHI-PROJECT-19K08438, KAKENHI-PROJECT-19K08461, KAKENHI-PROJECT-20K08304, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-18H02791, KAKENHI-PROJECT-20H03658, KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-19K17426, KAKENHI-PROJECT-17K19675, KAKENHI-PROJECT-21K15968
[Journal Article] TGF-β promotes fetal gene expression and cell migration velocity in a wound repair model of untransformed intestinal epithelial cells2020
- Author(s)
  Anzai Sho、Kawamoto Ami、Nagata Sayaka、Takahashi Junichi、Kawai Mao、Kuno Reiko、Kobayashi Sakurako、Watanabe Satoshi、Suzuki Kohei、Shimizu Hiromichi、Hiraguri Yui、Takeoka Sayaka、Sugihara Hady Yuki、Yui Shiro、Oshima Shigeru、Watanabe Mamoru、Okamoto Ryuichi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 524 Issue: 3 Pages: 533-541
- DOI
  10.1016/j.bbrc.2020.01.108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-17K19675
[Journal Article] High-fat diet-derived free fatty acids impair the intestinal immune system and increase sensitivity to intestinal epithelial damage2020
- Author(s)
  Tanaka Shohei、Nemoto Yasuhiro、Takei Yuria、Morikawa Ryo、Oshima Shigeru、Nagaishi Takashi、Okamoto Ryuichi、Tsuchiya Kiichiro、Nakamura Tetsuya、Stutte Susanne、Watanabe Mamoru
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 522 Issue: 4 Pages: 971-977
- DOI
  10.1016/j.bbrc.2019.11.158
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08364, KAKENHI-PROJECT-19K08388, KAKENHI-PROJECT-19K08438, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-18H02791, KAKENHI-PROJECT-19H03634, KAKENHI-PROJECT-17K09372, KAKENHI-PROJECT-18K19535, KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-17K19675, KAKENHI-PROJECT-17H04024
[Journal Article] Contribution of ATOH1 + Cells to the Homeostasis, Repair, and Tumorigenesis of the Colonic Epithelium2018
- Author(s)
  Ishibashi Fumiaki、Shimizu Hiromichi、Nakata Toru、Fujii Satoru、Suzuki Kohei、Kawamoto Ami、Anzai Sho、Kuno Reiko、Nagata Sayaka、Ito Go、Murano Tatsuro、Mizutani Tomohiro、Oshima Shigeru、Tsuchiya Kiichiro、Nakamura Tetsuya、Watanabe Mamoru、Okamoto Ryuichi
- Journal Title
  
  Stem Cell Reports
  
  Volume: 10 Issue: 1 Pages: 27-42
- DOI
  10.1016/j.stemcr.2017.11.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19674, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H05284, KAKENHI-PROJECT-17K19675, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-17H04024, KAKENHI-PROJECT-17K19513
[Journal Article] Ubiquitin D is Upregulated by Synergy of Notch Signalling and TNF-α in the Inflamed Intestinal Epithelia of IBD Patients2018
- Author(s)
  Kawamoto Ami、Nagata Sayaka、Anzai Sho、Takahashi Junichi、Kawai Mao、Hama Minami、Nogawa Daichi、Yamamoto Kouhei、Kuno Reiko、Suzuki Kohei、Shimizu Hiromichi、Hiraguri Yui、Yui Shiro、Oshima Shigeru、Tsuchiya Kiichiro、Nakamura Tetsuya、Ohtsuka Kazuo、Kitagawa Masanobu、Okamoto Ryuichi、Watanabe Mamoru
- Journal Title
  
  Journal of Crohn's and Colitis
  
  Volume: 13 Issue: 4 Pages: 495-509
- DOI
  10.1093/ecco-jcc/jjy180
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09370, KAKENHI-PROJECT-18K07902, KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-17K19675, KAKENHI-PROJECT-18K19535, KAKENHI-PROJECT-18K15743, KAKENHI-PROJECT-18K15774, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-16H05284, KAKENHI-PROJECT-17H04024, KAKENHI-PROJECT-18H02867, KAKENHI-PROJECT-17K19513, KAKENHI-PROJECT-17K19674, KAKENHI-PROJECT-18H02791
[Journal Article] Genetic and environmental factors drive personalized medicine for Crohn’s disease2018
- Author(s)
  Oshima Shigeru、Watanabe Mamoru
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 128 Issue: 11 Pages: 4758-4760
- DOI
  10.1172/jci124303
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-17K19675, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-17H04024, KAKENHI-PROJECT-17K19513
[Journal Article] Indispensable role of Notch ligand-dependent signaling in the proliferation and stem cell niche maintenance of APC-deficient intestinal tumors.2017
- Author(s)
  Nakata T, Shimizu H, Nagata S, Ito G, Fujii S, Suzuki K, Kawamoto A, Ishibashi F, Kuno R, Anzai S, Murano T, Mizutani T, Oshima S, Tsuchiya K, Nakamura T, Hozumi K, Watanabe M, Okamoto R
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 482 Issue: 4 Pages: 1296-1303
- DOI
  10.1016/j.bbrc.2016.12.031
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H05284
[Journal Article] Long-term inflammation transforms intestinal epithelial cells of colonic organoids.2017
- Author(s)
  Hibiya S, Tsuchiya K, Hayashi R, Horita N, Watanabe S, Shirasaki T, Nishimura R, Kimura N, Nishimura T, Gotoh N, Oshima S, Okamoto R, Nakamura T, Watanabe M
- Journal Title
  
  J Crohns Colitis.
  
  Volume: 61 Pages: 621-630
- DOI
  10.1093/ecco-jcc/jjw186
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H06770, KAKENHI-PROJECT-15K15287, KAKENHI-PROJECT-17K15930, KAKENHI-PROJECT-17H06654, KAKENHI-PROJECT-16K09302
[Journal Article] HADHA, the alpha subunit of the mitochondrial trifunctional protein,is involved in long-chain fatty acid-induced autophagy in intestinal epithelial cells.2017
- Author(s)
  Maeyashiki C, Oshima S, Otsubo K, Kobayashi M, Nibe Y, Matsuzawa Y, Onizawa M, Nemoto Y, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Watanabe M
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 484 Issue: 3 Pages: 636-641
- DOI
  10.1016/j.bbrc.2017.01.159
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H05286, KAKENHI-PROJECT-16H06771, KAKENHI-PROJECT-15K15288, KAKENHI-PROJECT-16K15423
[Journal Article] Novel polyubiquitin imaging system, PolyUb-FC, reveals that K33-linked polyubiquitin is recruited by p62/SQSTM1.2017
- Author(s)
  Yoichi Nibe, Shigeru Oshima, Masanori Kobayashi, Chiaki Maeyashiki, Yu Matsuzawa, Kana Otsubo, Hiroki Matsuda, Emi Aonuma, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Shinichiro Nakada, Mamoru Watanabe
- Journal Title
  
  Autophagy.
  
  Volume: 22 Issue: 2 Pages: 1-43
- DOI
  10.1080/15548627.2017.1407889
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09372, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H05284, KAKENHI-PROJECT-16H05286, KAKENHI-PROJECT-16K15423, KAKENHI-PROJECT-17K19675, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-17H04024, KAKENHI-PROJECT-17K19513, KAKENHI-PROJECT-26241014
[Journal Article] The ubiquitin hybrid gene UBA52 regulates ubiquitination of ribosome and sustains embryonic development.2016
- Author(s)
  Kobayashi M, Oshima S, Maeyashiki C, Nibe Y, Otsubo K, Matsuzawa Y, Memoto Y, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Watanabe M
- Journal Title
  
  Sci. Rep.
  
  Volume: 6 Issue: 1 Pages: 36780-36780
- DOI
  10.1038/srep36780
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H05286, KAKENHI-PROJECT-26460963, KAKENHI-PROJECT-15K15288
[Journal Article] Data showing proliferation and differentiation of intestinal epithelial cells under targeted depletion of Notch ligands in mouse intestine.2016
- Author(s)
  Nakata T, Shimizu H, Nagata S, Ito G, Fujii S, Suzuki K, Kawamoto A, Ishibashi F, Kuno R, Anzai S, Murano T, Mizutani T, Oshima S, Tsuchiya K, Nakamura T, Hozumi K, Watanabe M, Okamoto R
- Journal Title
  
  Data Brief.
  
  Volume: 10 Pages: 551-556
- DOI
  10.1016/j.dib.2016.12.045
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H05284
[Journal Article] PGE2 is a direct and robust mediator of anion/fluid secretion by human intestinal epithelial cells.2016
- Author(s)
  Fujii S, Okamoto R, Suzuki K, Kawamoto A, Ishibashi F, Nakata T, Murano T, Ito G, Shimizu H, Mizutani T, Oshima S, Tsuchiya K, Nakamura T, Araki A, Ohtsuka K, Watanabe M
- Journal Title
  
  Sci. Rep.
  
  Volume: 6 Issue: 1 Pages: 36795-36795
- DOI
  10.1038/srep36795
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-15K15286, KAKENHI-PROJECT-16K09302
[Journal Article] The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis.2015
- Author(s)
  Onizawa M, Oshima S, Schulze-Topphoff U, Oses-Prieto JA, Lu T, Tavares R, Prodhomme T, Duong B, Whang MI, Advincula R, Agelidis A, Barrera J, Wu H, Burlingame A, Malynn BA, Zamvil SS, Ma A.
- Journal Title
  
  Nat Immunol
  
  Volume: 16 Issue: 6 Pages: 618-27
- DOI
  10.1038/ni.3172
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460946
[Journal Article] Atonal homolog 1 protein stabilized by tumor necrosis factor α induces high malignant potential in colon cancer cell line.2015
- Author(s)
  Keita Fukushima, Kiichiro Tsuchiya,Okamoto Ryuichi, Mamoru Watanabe,et al
- Journal Title
  
  Cancer Sci
  
  Volume: 106 Issue: 8 Pages: 1000-7
- DOI
  10.1111/cas.12703
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K15286, KAKENHI-PROJECT-15K15287, KAKENHI-PROJECT-15K15288, KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-25293170
[Journal Article] TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy.2015
- Author(s)
  Matsuzawa Y, Oshima S, Takahara M, Maeyashiki C, Nemoto Y, Kobayashi M, Nibe Y, Nozaki K, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Averil Ma, Watanabe M
- Journal Title
  
  Autophagy
  
  Volume: 11 Issue: 7 Pages: 1052-1062
- DOI
  10.1080/15548627.2015.1055439
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460963, KAKENHI-PROJECT-15K15286, KAKENHI-PROJECT-15K15288, KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-25460946, KAKENHI-PROJECT-25293170
[Journal Article] RIPK3 regulates p62-LC3 complex formation via the caspase-8-dependent cleavage of p62.2014
- Author(s)
  Y. Matsuzawa , S. Oshima, Y. Nibe, M.Kobayashi, C. Maeyashiki, Y. Nemoto, T. Nagaishi, R. Okamoto R, K. Tsuchiya, T. Nakamura, M. Watanabe.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 456(1) Issue: 1 Pages: 298-304
- DOI
  10.1016/j.bbrc.2014.11.075
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-24590935, KAKENHI-PROJECT-24590936, KAKENHI-PROJECT-24590937, KAKENHI-PUBLICLY-25114703, KAKENHI-PUBLICLY-25130704, KAKENHI-PROJECT-25293170, KAKENHI-PROJECT-25460946, KAKENHI-PROJECT-26460963, KAKENHI-PROJECT-26221307
[Journal Article] ABIN-1 protects against psoriasis by restricting MyD88 signals in dendritic cells.2013
- Author(s)
  Callahan JA1, Hammer GE, Agelides A, Duong BH, Oshima S, North J, Advincula R, Shifrin N, Truong HA, Paw J, Barrera J, DeFranco A, Rosenblum MD, Malynn BA, Ma A.
- Journal Title
  
  J Immunol.
  
  Volume: 191 Issue: 2 Pages: 535-9
- DOI
  10.4049/jimmunol.1203335
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460946
[Journal Article] A20 restricts wnt signaling in intestinal epithelial cells and suppresses colon carcinogenesis.2013
- Author(s)
  Shao L, Oshima S, Duong B, Advincula R, Barrera J, Malynn BA, Ma A.
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 5 Pages: e62223-e62223
- DOI
  10.1371/journal.pone.0062223
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460946
[Presentation] 腸管炎症惹起機構における生命金属の役割2021
- Author(s)
  大島　茂、松田浩紀、青沼映美、田村皓子、仁部洋一、渡辺守、宇尾基弘、岡本隆一
- Organizer
  第94回日本生化学学会大会
- Data Source
  KAKENHI-PROJECT-21H02897
[Presentation] 生命金属による腸管炎症・惹起機構の解析2021
- Author(s)
  松田浩紀、青沼映美、田村皓子、仁部洋一、渡辺守、岡本隆一、宇尾基弘、大島茂.
- Organizer
  第58回日本消化器免疫学会
- Data Source
  KAKENHI-PROJECT-21H02897
[Presentation] K33-linked polyubiquitin is recruited by SQSTM1/p622019
- Author(s)
  Shigeru Oshima, Yoichi Nibe, Akiko Tamura, Hiroki Matsuda, Emi Aonuma, Kana Otsubo, and Mamoru Watanabe.
- Organizer
  Keystone Symposia: Autophagy(B2)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07934
[Presentation] K33鎖ユビキチン鎖の機能解析2019
- Author(s)
  大島茂
- Organizer
  新学術領域研究「ネオユビキチン」令和元年度第3回領域班会議
- Data Source
  KAKENHI-PROJECT-18K07934
[Presentation] 非定型ユビキチン鎖の機能解明2019
- Author(s)
  大島　茂
- Organizer
  第１回新学術「ケモユビキチン」班会議・第２回ユビキチン研究会合同会議
- Data Source
  KAKENHI-PROJECT-18K07934
[Presentation] The role of ubiquitination in crosstalk of intestinal epithelial cell death and autophagic signaling was revealed by a novel polyubiquitin imaging system2019
- Author(s)
  Kana Otsubo, Yoichi Nibe, Chiaki Maeyashiki, Akiko Tamura, Emi Aonuma, Hiroki Matsuda, Mamoru Watanabe, Shigeru Oshima
- Organizer
  19th International congress of mucosal immunology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07934
[Presentation] ユビキチンコード遺伝子の大腸腫瘍における役割2019
- Author(s)
  大島茂、小林正典、田村皓子、松田浩紀、青沼映美、大坪加奈、仁部洋一、渡辺守
- Organizer
  第56回日本消化器免疫学会
- Data Source
  KAKENHI-PROJECT-18K07934
[Presentation] Novel polyubiquitin imaging system, PolyUb-FC, visualized atypical polyubiquitin chain in living cells2018
- Author(s)
  Yoichi Nibe, Hiroki Matsuda, Emi Aonuma, Kana Otsubo, Chiaki Maeyashiki, Masanori Kobayashi, Yu Matsuzawa, Shinichiro Nakada, Mamoru Watanabe, Shigeru Oshima
- Organizer
  Keystone Symposia - Ubiquitin Signaling
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04808
[Presentation] 免疫疾患制御を目標としたユビキチン鎖可視化技術（PolyUb-FC）の開発2018
- Author(s)
  大島　茂、仁部洋一、田村皓子、青沼映美、松田浩紀、大坪加奈、鬼澤道夫、渡辺　守
- Organizer
  第46回日本臨床免疫学会総会
- Data Source
  KAKENHI-PROJECT-18K07934
[Presentation] Necroptosis stimulation regulates SQSTM1/p62-LC3 complex formation and polyubiquitination.2018
- Author(s)
  Aonuma E, Nibe Y, Matsuda H, Otsubo K, Maeyashiki C, Kobayashi M, Matsuzawa Y, Watanabe M, and Oshima S
- Organizer
  Keystone Symposia - Ubiquitin Signaling (A8)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15423
[Presentation] Necroptosis stimulation regulates SQSTM1/p62-LC3 complex formation and polyubiquitination2018
- Author(s)
  Emi Aonuma, Yoichi Nibe, Hiroki Matsuda, Kana Otsubo, Chiaki Maeyashiki, Masanori Kobayashi, Yu Matsuzawa, Mamoru Watanabe, Shigeru Oshima
- Organizer
  Keystone Symposia - Ubiquitin Signaling
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04808
[Presentation] 独自ポリユビキチン鎖可視化技術を用いた新規腸炎調節分子の同定2018
- Author(s)
  大島　茂、仁部洋一、松田浩紀、田村皓子、青沼映美、大坪加奈、渡辺　守
- Organizer
  第55回日本消化器免疫学会総会
- Data Source
  KAKENHI-PROJECT-18K07934
[Presentation] K33-linked polyubiquitin is recruited by SQSTM1/p622018
- Author(s)
  Hiroki Matsuda, Yoichi Nibe, Emi Aonuma, Kana Otsubo, Chiaki Maeyashiki, Masanori Kobayashi, Yu Matsuzawa, Shinichiro Nakada, Mamoru Watanabe and Shigeru Oshima
- Organizer
  Keystone Symposia - Ubiquitin Signaling
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04808
[Presentation] Novel polyubiquitin imaging system, PolyUb-FC, visualized atypical polyubiquitin chain in living cells2018
- Author(s)
  Nibe Y, Matsuda H, Aonuma E, Otsubo K, Maeyashiki C, Kobayashi M, Matsuzawa Y, Nakada S, Watanabe M, and Oshima S
- Organizer
  Keystone Symposia - Ubiquitin Signaling (A8)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15423
[Presentation] Long-chain fatty acid regulates autophagy and polyubiquitination in intestinal epithelial cells2018
- Author(s)
  Kana Otsubo, Chiaki Maeyashiki, Emi Aonuma, Hiroki Matsuda, Yoichi Nibe, Masanori Kobayashi, Yu Matsuzawa, Mamoru Watanabe, Shigeru Oshima
- Organizer
  Keystone Symposia - Ubiquitin Signaling
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04808
[Presentation] Novel polyubiquitin imaging reveals that atypical polyubiquitin contribute to autophagy via p622017
- Author(s)
  Nibe Y, Oshima S, Aonuma E, Matsuda H, Otsubo K, Maeyashiki C, Kobayashi M, Matsuzawa Y, Nakada S, Watanabe M.
- Organizer
  The 8th International Symposium on Autophagy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15423
[Presentation] TP53 mutation acquires higher malignant potential in human colon cancer cells2017
- Author(s)
  Watanabe S, Tsuchiya K, Shirasaki T, Hibiya S, Oshima S, Nakamura T, Nishimura R, Okamoto R, Watanabe M.
- Organizer
  UEGW2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04808
[Presentation] Novel polyubiquitin imaging reveals that atypical polyubiquitin contribute to autophagy2017
- Author(s)
  Nibe　Y, Oshima S, Aonuma E, Matsuda H, Otsubo K, Maeyashiki C, Kobayashia M, Matsuzawa Y , Nakada S, Watanabe M.
- Organizer
  GI research Academy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15423
[Presentation] HADHA, the alpha subunit of the mitochondrial trifunctional protein, is involved in long-chain fatty acid-induced autophagy in intestinal epithelial cells.2017
- Author(s)
  Otsubo K, Oshima S, Maeyashiki C, Aonuma E, Matsuda H, Kobayashi M, Nibe Y, Matsuzawa Y, Watanabe M
- Organizer
  The 8th International Symposium on Autophagy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15423
[Presentation] Construction of in vitro model for inflammatory bowel disease using primary colonic organoid.2016
- Author(s)
  Syuji Hibiya, Kiichiro Tsuchiya, Tomoaki Shirasaki, Keita Fukushima, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe.
- Organizer
  DDW2016
- Place of Presentation
  San Diego（USA）
- Year and Date
  2016-05-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04808
[Presentation] Mouse colonic organoid acquires wnt-independent survival property after long-term inflammation.2016
- Author(s)
  Shuji Hibiya, Kiichiro Tsuchiya, Tomoaki Shirasaki, Keita Fukushima, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe.
- Organizer
  AOCC2016
- Place of Presentation
  Kyoto International Conference Center, Kyoto（JAPAN）
- Year and Date
  2016-07-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04808
[Presentation] 長期炎症刺激による大腸上皮培養細胞の非可逆的NF κB シグナル活性.2016
- Author(s)
  日比谷秀爾、土屋輝一郎、白崎友彬、福島啓太、大島　茂、岡本隆一、中村哲也、渡辺　守.
- Organizer
  第102回日本消化器病学会総会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-15H04808
[Presentation] Atoh1 protein stabilization in colon tumor acquires the phenotype of signet ring cell carcinoma with cancer stem cell enrichment.2016
- Author(s)
  Kiichiro Tsuchiya, Shuji Hibiya, Keita Fukushima, Tomoaki Shirasaki, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe.
- Organizer
  AOCC2016
- Place of Presentation
  Kyoto International Conference Center, Kyoto（JAPAN）
- Year and Date
  2016-07-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04808
[Presentation] Construction of in vitro model of ulcerative colitis using mouse primary colonic organoid.2016
- Author(s)
  Hibiya S, Tsuchiya K, Watanabe S, Shirasaki T, Oshima S, Okamoto R, Nakamura T, Watanabe M.
- Organizer
  UEGW2016
- Place of Presentation
  Vienna（Austria）
- Year and Date
  2016-10-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04808
[Presentation] UBA52, ubiquitin hybrid ribisomal protein, regulates NF-κB signaling in colon cancer.2016
- Author(s)
  Masanori Kobayashi, Shigeru Oshima, Yoishi Nibe, Chiaki Maeyashiki, Mamoru Watanabe.
- Organizer
  DDW2016
- Place of Presentation
  San Diego（USA）
- Year and Date
  2016-05-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04808
[Presentation] Atoh1 protein stabilization in colon tumor acquires the　morphological change to signet ring cell carcinoma with cancer stem cell enrichment.2016
- Author(s)
  Tsuchiya K, Hibiya S, Fukushima K, Shirasaki T, Oshima S, Okamoto R, Nakamura T, Watanabe M.
- Organizer
  APDW2016
- Place of Presentation
  Kobe convention center, KOBE（JAPAN）
- Year and Date
  2016-11-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04808
[Presentation] Indentification of autophagic regulators as therapeutic targets in intestinal epithelial cells.2016
- Author(s)
  Chiaki Maeyashiki, Shigeru Oshima, Yoishi Nibe, Masanori Kobayashi, Mamoru Watanabe.
- Organizer
  DDW
- Place of Presentation
  San Diego (USA)
- Year and Date
  2016-05-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15423
[Presentation] A Crohn's Disease Susceptibility Gene A20 Regulates Autophagy Dynamics in CD4 T Cells2015
- Author(s)
  Yu Matsuzawa, Shigeru Oshima, Masanori Kobayashi, Yoichi Nibe, Chiaki Maeyashiki, Averil I. Ma, Mamoru Watanabe
- Organizer
  DDW(Digestive Disease Week)
- Place of Presentation
  Washington, DC（USA）
- Year and Date
  2015-05-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460946

1. WATANABE Mamoru (10175127)

# of Collaborated Projects: 3 results

# of Collaborated Products: 30 results
2. TSUCHIYA Kiichiro (40376786)

# of Collaborated Projects: 3 results

# of Collaborated Products: 14 results
3. OKADA Eriko (20376784)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. KUBOTA Daisuke (00376790)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. Kobayashi Masanori (10825459)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 柿沼晴 (30372444)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 宇尾基弘 (20242042)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. 岡本隆一 (50451935)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
9. TORII Satoru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 永石宇治

# of Collaborated Projects: 0 results

# of Collaborated Products: 11 results
11. 鬼澤道夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
12. 齊藤詠子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
13. 中村哲也

# of Collaborated Projects: 0 results

# of Collaborated Products: 8 results
14. 石田純治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 大塚和朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 油井史郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 藤谷与士夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Oshima Shigeru 大島 茂

大島 茂 オオシマ シゲル

Research Projects

Research Products

Co-Researchers

the role of biometal in the intestinal environmentPrincipal Investigator

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Analysis of a novel molecular mechanism in bile duct carcinoma using a human iPS cell-derived cholangiocyte culture system

Principal Investigator

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Establishment of granuloma formation model based on molecular response analysisPrincipal Investigator

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Analysis of negative regulator of necroptosisPrincipal Investigator

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Inflammation related carcinogenesis by spiral cell transformation using in vitro chronic colitis model

Principal Investigator

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The mechanism of autoantibody production in IBDPrincipal Investigator

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慢性大腸炎粘膜局所T細胞の特異的増殖機構解明と新規治療法開発Principal Investigator

Principal Investigator

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Research Institution

Identification of the Notch signal in intestinal epithelial cells and the failure of the intestinal differentiation in chronic colitis.

Principal Investigator

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Research Institution

[Journal Article] Single cell analysis revealed that two distinct, unique CD4+ T cell subsets were increased in the small intestinal intraepithelial lymphocytes of aged mice.2024

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Data Source

[Journal Article] Apelin expression is downregulated in T cells in a murine model of chronic colitis2023

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DOI

Data Source

[Journal Article] Novel-time resolved reporter mouse reveals spatial and transcriptional heterogeneity during alpha cell differentiation2023

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DOI

Data Source

[Journal Article] Zranb1-mutant mice display abnormal colonic mucus production and exacerbation of DSS-induced colitis.2022

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DOI

Data Source

[Journal Article] Nickel particles are present in Crohn's disease tissue and exacerbate intestinal inflammation in IBD susceptible mice.2022

Author(s)

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DOI

Data Source

[Journal Article] Oral administration of D-serine prevents the onset and progression of colitis in mice.2021

Author(s)

Oshima Shigeru 大島茂

大島茂オオシマシゲル