Oshima Shigeru 大島茂

… Alternative Names

Researcher Number	50376787
Other IDs
Affiliation (Current)	2020: 東京医科歯科大学, 医学部附属病院, 講師
Affiliation (based on the past Project Information) *help	2017 – 2019: 東京医科歯科大学, 医学部附属病院, 講師 2015 – 2017: 東京医科歯科大学, 医学部附属病院, 助教 2013 – 2014: 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 2006: 医科歯科大, 医学部附属病院 2005: 東京医科歯科大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related Except Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related
Keywords	Principal Investigator オートファジー / 炎症性腸疾患 / クローン病 / ユビキチン / IL-7 recepter / IL-7 / CD45RBhigh / TCRa- / - / STAT5 … More Except Principal Investigator Notch / 慢性大腸炎 / 大腸上皮再生 / 幹細胞 / Notchシグナル / 腸管分化 / 転写因子 / Chronic colitis / Regeneration / Stem Cell / Atoh1 / 炎症発癌 / 自然免疫応答 / 持続炎症刺激モデル / 持続炎症 / 炎症性腸疾患 / シグナルスパイラル / ヒトiPS細胞 / 胆管癌 / 疾患モデル / 胆管上皮細胞 / iPS細胞 / 胆汁 / 発癌機序 Less

ヒトiPS細胞由来胆管細胞培養系を用いた胆管癌における新規発癌機序の解明Ongoing
- Principal Investigator
  
  小林正典
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokyo Medical and Dental University
分子応答解析に基づく肉芽腫形成モデルの樹立Principal InvestigatorOngoing
- Principal Investigator
  
  大島茂
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokyo Medical and Dental University
Analysis of negative regulator of necroptosisPrincipal Investigator
- Principal Investigator
  
  OSHIMA Shigeru
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
Inflammation related carcinogenesis by spiral cell transformation using in vitro chronic colitis model
- Principal Investigator
  
  TSUCHIYA Kiichiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
The mechanism of autoantibody production in IBDPrincipal Investigator
- Principal Investigator
  
  Oshima Shigeru
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
慢性大腸炎粘膜局所T細胞の特異的増殖機構解明と新規治療法開発Principal Investigator
- Principal Investigator
  
  大島茂
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
Identification of the Notch signal in intestinal epithelial cells and the failure of the intestinal differentiation in chronic colitis.
- Principal Investigator
  
  OKADA Eriko
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University

All 2020 2019 2018 2017 2016 2015 2013

All Journal Article Presentation

[Journal Article] TGF-β promotes fetal gene expression and cell migration velocity in a wound repair model of untransformed intestinal epithelial cells2020
- Author(s)
  Anzai Sho、Kawamoto Ami、Nagata Sayaka、Takahashi Junichi、Kawai Mao、Kuno Reiko、Kobayashi Sakurako、Watanabe Satoshi、Suzuki Kohei、Shimizu Hiromichi、Hiraguri Yui、Takeoka Sayaka、Sugihara Hady Yuki、Yui Shiro、Oshima Shigeru、Watanabe Mamoru、Okamoto Ryuichi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 524 Pages: 533-541
- DOI
  10.1016/j.bbrc.2020.01.108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-19H01050
[Journal Article] High-fat diet-derived free fatty acids impair the intestinal immune system and increase sensitivity to intestinal epithelial damage.2020
- Author(s)
  Tanaka Shohei、Nemoto Yasuhiro、Takei Yuria、Morikawa Ryo、Oshima Shigeru、Nagaishi Takashi、Okamoto Ryuichi、Tsuchiya Kiichiro、Nakamura Tetsuya、Stutte Susanne、Watanabe Mamoru
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 522 Pages: 971-977
- DOI
  10.1016/j.bbrc.2019.11.158
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-19K08364, KAKENHI-PROJECT-19K08388, KAKENHI-PROJECT-19K08438, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-18H02791, KAKENHI-PROJECT-19H03634, KAKENHI-PROJECT-17K09372, KAKENHI-PROJECT-18K19535
[Journal Article] T cells show amoeboid shape and frequent morphological change in vitro, and localize to small intestinal intraepithelial region in vivo.2020
- Author(s)
  Takei Yuria、Nemoto Yasuhiro、Morikawa Ryo、Tanaka Shohei、Oshima Shigeru、Nagaishi Takashi、Okamoto Ryuichi、Tsuchiya Kiichiro、Nakamura Tetsuya、Watanabe Mamoru
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 523 Pages: 328-335
- DOI
  10.1016/j.bbrc.2019.12.021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-19K08364, KAKENHI-PROJECT-19K08388, KAKENHI-PROJECT-19K08438, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-18H02791, KAKENHI-PROJECT-19H03634, KAKENHI-PROJECT-17K09372, KAKENHI-PROJECT-18K19535
[Journal Article] Receotir-Interacting Protein Kinase3（RIPK3）inhibits autophagic flux furing necroptosis in intestinal epithelial cells.2020
- Author(s)
  Otsubo K, Maeyashiki C, Nibe Y, Tamura A, Aonuma E, Matsuda H, Kobayashi M, Onizawa M, Nemoto Y, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Torii S, Itakura E, Watanabe M, Oshima S.
- Journal Title
  
  FEBS Lett.
  
  Volume: 594 Pages: 1586-1595
- DOI
  10.1002/1873-3468.13748
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06210, KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-19K08364, KAKENHI-PROJECT-19K08388, KAKENHI-PROJECT-19K08438, KAKENHI-PROJECT-19K22413, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-16H06167, KAKENHI-PROJECT-17K09372
[Journal Article] Ubiquitin D is up-regulated by synergy of Notch signaling and TNF-α in the inflamed intestinal epithelia of IBD patients.2019
- Author(s)
  Kawamoto Ami、Nagata Sayaka、Anzai Sho、Takahashi Junichi、Kawai Mao、Hama Minami、Nogawa Daichi、Yamamoto Kouhei、Kuno Reiko、Suzuki Kohei、Shimizu Hiromichi、Hiraguri Yui、Yui Shiro、Oshima Shigeru、Tsuchiya Kiichiro、Nakamura Tetsuya、Ohtsuka Kazuo、Kitagawa Masanobu、Okamoto Ryuichi、Watanabe Mamoru
- Journal Title
  
  J Crohns Colitis
  
  Volume: 13 Pages: 495-509
- DOI
  10.1093/ecco-jcc/jjy180
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09370, KAKENHI-PROJECT-18K07902, KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-17K19675, KAKENHI-PROJECT-18K19535, KAKENHI-PROJECT-18K15743, KAKENHI-PROJECT-18K15774, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-16H05284, KAKENHI-PROJECT-17H04024, KAKENHI-PROJECT-18H02867, KAKENHI-PROJECT-17K19513, KAKENHI-PROJECT-17K19674, KAKENHI-PROJECT-18H02791
[Journal Article] Genetic and environmental factors drive personalized medicine for Crohn’s disease.2019
- Author(s)
  Oshima Shigeru、Watanabe Mamoru
- Journal Title
  
  J Clin Invest.
  
  Volume: 128 Pages: 4758-4760
- DOI
  10.1172/jci124303
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-17K19675, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-17H04024, KAKENHI-PROJECT-17K19513
[Journal Article] Contribution of ATOH1+ cells to the homeostasis, repair and tumorigenesis of the colonic epithelium.2018
- Author(s)
  Ishibashi Fumiaki、Shimizu Hiromichi、Nakata Toru、Fujii Satoru、Suzuki Kohei、Kawamoto Ami、Anzai Sho、Kuno Reiko、Nagata Sayaka、Ito Go、Murano Tatsuro、Mizutani Tomohiro、Oshima Shigeru、Tsuchiya Kiichiro、Nakamura Tetsuya、Watanabe Mamoru、Okamoto Ryuichi
- Journal Title
  
  Stem Cell Rep.
  
  Volume: 10 Pages: 27-42
- DOI
  10.1016/j.stemcr.2017.11.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19674, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H05284, KAKENHI-PROJECT-17K19675, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-17H04024, KAKENHI-PROJECT-17K19513
[Journal Article] Novel polyubiquitin imaging system, PolyUb-FC, reveals that K33-linked polyubiquitin is recruited by SQSTM1/p62.2018
- Author(s)
  Yoichi Nibe, Shigeru Oshima, Masanori Kobayashi, Chiaki Maeyashiki, Yu Matsuzawa, Kana Otsubo, Hiroki Matsuda, Emi Aonuma, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Shinichiro Nakada, Mamoru Watanabe
- Journal Title
  
  Autophagy
  
  Volume: 22 Pages: 347-358
- DOI
  10.1080/15548627.2017.1407889
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09372, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H05284, KAKENHI-PROJECT-16H05286, KAKENHI-PROJECT-16K15423, KAKENHI-PROJECT-17K19675, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-17H04024, KAKENHI-PROJECT-17K19513, KAKENHI-PROJECT-26241014
[Journal Article] Data showing proliferation and differentiation of intestinal epithelial cells under targeted depletion of Notch ligands in mouse intestine.2017
- Author(s)
  Nakata T, Shimizu H, Nagata S, Ito G, Fujii S, Suzuki K, Kawamoto A, Ishibashi F, Kuno R, Anzai S, Murano T, Mizutani T, Oshima S, Tsuchiya K, Nakamura T, Hozumi K, Watanabe M, Okamoto R
- Journal Title
  
  Data in Brief
  
  Volume: 10 Pages: 551-556
- DOI
  10.1016/j.dib.2016.12.045
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H05284
[Journal Article] HADHA, the alpha subunit of the mitochondrial trifunctional protein, is involved in long-chain fatty acid-induced autophagy in intestinal epithelial cells.2017
- Author(s)
  Maeyashiki C, Oshima S, Otsubo K, Kobayashi M, Nibe Y, Matsuzawa Y, Onizawa M, Nemoto Y, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Watanabe M
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 484 Pages: 636-641
- DOI
  10.1016/j.bbrc.2017.01.159
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H05286, KAKENHI-PROJECT-16H06771, KAKENHI-PROJECT-15K15288, KAKENHI-PROJECT-16K15423
[Journal Article] Long-term Inflammation Transforms Intestinal Epithelial Cells of Colonic Organoids2017
- Author(s)
  Hibiya S, Tsuchiya K, Hayashi R, Horita N, Watanabe S, Shirasaki T, Nishimura R, Kimura N, Nishimura T, Gotoh N, Oshima S, Okamoto R, Nakamura T, Watanabe M
- Journal Title
  
  Journal of Crohn's and Colitis
  
  Volume: 61 Pages: 621-630
- DOI
  10.1093/ecco-jcc/jjw186
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H06770, KAKENHI-PROJECT-15K15287, KAKENHI-PROJECT-17K15930, KAKENHI-PROJECT-17H06654, KAKENHI-PROJECT-16K09302
[Journal Article] Indispensable role of Notch ligand-dependent signaling in the proliferation and stem cell niche maintenance of APC-deficient intestinal tumors.2017
- Author(s)
  Nakata T, Shimizu H, Nagata S, Ito G, Fujii S, Suzuki K, Kawamoto A, Ishibashi F, Kuno R, Anzai S, Murano T, Mizutani T, Oshima S, Tsuchiya K, Nakamura T, Hozumi K, Watanabe M, Okamoto R
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 482 Pages: 1296-1303
- DOI
  10.1016/j.bbrc.2016.12.031
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H05284
[Journal Article] The ubiquitin hybrid gene UBA52 regulates ubiquitination of ribosome and sustains embryonic development.2016
- Author(s)
  Kobayashi M, Oshima S, Maeyashiki C, Nibe Y, Otsubo K, Matsuzawa Y, Memoto Y, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Watanabe M
- Journal Title
  
  Sci Rep
  
  Volume: 6 Pages: 36780-36780
- DOI
  10.1038/srep36780
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H05286, KAKENHI-PROJECT-26460963, KAKENHI-PROJECT-15K15288
[Journal Article] PGE2 is a direct and robust mediator of anion/fluid secretion by human intestinal epithelial cells2016
- Author(s)
  Fujii S, Okamoto R, Suzuki K, Kawamoto A, Ishibashi F, Nakata T, Murano T, Ito G, Shimizu H, Mizutani T, Oshima S, Tsuchiya K, Nakamura T, Araki A, Ohtsuka K, Watanabe M
- Journal Title
  
  Sci Rep
  
  Volume: 6 Pages: 36795-36795
- DOI
  10.1038/srep36795
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-15K15286, KAKENHI-PROJECT-16K09302
[Journal Article] TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy.2015
- Author(s)
  Matsuzawa Y, Oshima S, Takahara M, Maeyashiki C, Nemoto Y, Kobayashi M, Nibe Y, Nozaki K, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Averil Ma, Watanabe M
- Journal Title
  
  Autophagy
  
  Volume: 11 Pages: 1052-1062
- DOI
  10.1080/15548627.2015.1055439
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460963, KAKENHI-PROJECT-15K15286, KAKENHI-PROJECT-15K15288, KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-25460946, KAKENHI-PROJECT-25293170
[Journal Article] Atonal homolog 1 protein stabilized by tumor necrosis factor α induces high malignant potential in colon cancer cell line.2015
- Author(s)
  Keita Fukushima, Kiichiro Tsuchiya,Okamoto Ryuichi, Mamoru Watanabe,et al
- Journal Title
  
  Cancer Sci.
  
  Volume: 106 Pages: 1000-1007
- DOI
  10.1111/cas.12703
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K15286, KAKENHI-PROJECT-15K15287, KAKENHI-PROJECT-15K15288, KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-25293170
[Journal Article] The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis.2015
- Author(s)
  Onizawa M, Oshima S, Schulze-Topphoff U, Oses-Prieto JA, Lu T, Tavares R, Prodhomme T, Duong B, Whang MI, Advincula R, Agelidis A, Barrera J, Wu H, Burlingame A, Malynn BA, Zamvil SS, Ma A.
- Journal Title
  
  Nat Immunol
  
  Volume: 16 Pages: 618-27
- DOI
  10.1038/ni.3172
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460946
[Journal Article] RIPK3 regulates p62- LC3 complex formation via the caspase-8-dependent cleavage of p622015
- Author(s)
  Y. Matsuzawa , S. Oshima, Y. Nibe, M.Kobayashi, C. Maeyashiki, Y. Nemoto, T. Nagaishi, R. Okamoto R, K. Tsuchiya, T. Nakamura, M. Watanabe.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 456(1) Pages: 298-304
- DOI
  10.1016/j.bbrc.2014.11.075
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-24590935, KAKENHI-PROJECT-24590936, KAKENHI-PROJECT-24590937, KAKENHI-PUBLICLY-25114703, KAKENHI-PUBLICLY-25130704, KAKENHI-PROJECT-25293170, KAKENHI-PROJECT-25460946, KAKENHI-PROJECT-26460963, KAKENHI-PROJECT-26221307
[Journal Article] ABIN-1 protects against psoriasis by restricting MyD88 signals in dendritic cells.2013
- Author(s)
  Callahan JA1, Hammer GE, Agelides A, Duong BH, Oshima S, North J, Advincula R, Shifrin N, Truong HA, Paw J, Barrera J, DeFranco A, Rosenblum MD, Malynn BA, Ma A.
- Journal Title
  
  J Immunol.
  
  Volume: 191 Pages: 535-9
- DOI
  10.4049/jimmunol.1203335
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460946
[Journal Article] A20 restricts wnt signaling in intestinal epithelial cells and suppresses colon carcinogenesis.2013
- Author(s)
  Shao L, Oshima S, Duong B, Advincula R, Barrera J, Malynn BA, Ma A.
- Journal Title
  
  PLoS One
  
  Volume: 8
- DOI
  10.1371/journal.pone.0062223
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460946
[Presentation] K33-linked polyubiquitin is recruited by SQSTM1/p622019
- Author(s)
  Shigeru Oshima, Yoichi Nibe, Akiko Tamura, Hiroki Matsuda, Emi Aonuma, Kana Otsubo, and Mamoru Watanabe.
- Organizer
  Keystone Symposia: Autophagy(B2)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07934
[Presentation] The role of ubiquitination in crosstalk of intestinal epithelial cell death and autophagic signaling was revealed by a novel polyubiquitin imaging system2019
- Author(s)
  Kana Otsubo, Yoichi Nibe, Chiaki Maeyashiki, Akiko Tamura, Emi Aonuma, Hiroki Matsuda, Mamoru Watanabe, Shigeru Oshima
- Organizer
  19th International congress of mucosal immunology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07934
[Presentation] ユビキチンコード遺伝子の大腸腫瘍における役割2019
- Author(s)
  大島茂、小林正典、田村皓子、松田浩紀、青沼映美、大坪加奈、仁部洋一、渡辺守
- Organizer
  第56回日本消化器免疫学会
- Data Source
  KAKENHI-PROJECT-18K07934
[Presentation] K33鎖ユビキチン鎖の機能解析2019
- Author(s)
  大島茂
- Organizer
  新学術領域研究「ネオユビキチン」令和元年度第3回領域班会議
- Data Source
  KAKENHI-PROJECT-18K07934
[Presentation] 非定型ユビキチン鎖の機能解明2019
- Author(s)
  大島　茂
- Organizer
  第１回新学術「ケモユビキチン」班会議・第２回ユビキチン研究会合同会議
- Data Source
  KAKENHI-PROJECT-18K07934
[Presentation] Long-chain fatty acid regulates autophagy and polyubiquitination in intestinal epithelial cells2018
- Author(s)
  Kana Otsubo, Chiaki Maeyashiki, Emi Aonuma, Hiroki Matsuda, Yoichi Nibe, Masanori Kobayashi, Yu Matsuzawa, Mamoru Watanabe, Shigeru Oshima
- Organizer
  Keystone Symposia - Ubiquitin Signaling
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04808
[Presentation] K33-linked polyubiquitin is recruited by SQSTM1/p622018
- Author(s)
  Hiroki Matsuda, Yoichi Nibe, Emi Aonuma, Kana Otsubo, Chiaki Maeyashiki, Masanori Kobayashi, Yu Matsuzawa, Shinichiro Nakada, Mamoru Watanabe and Shigeru Oshima
- Organizer
  Keystone Symposia - Ubiquitin Signaling
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04808
[Presentation] 免疫疾患制御を目標としたユビキチン鎖可視化技術（PolyUb-FC）の開発2018
- Author(s)
  大島　茂、仁部洋一、田村皓子、青沼映美、松田浩紀、大坪加奈、鬼澤道夫、渡辺　守
- Organizer
  第46回日本臨床免疫学会総会
- Data Source
  KAKENHI-PROJECT-18K07934
[Presentation] Necroptosis stimulation regulates SQSTM1/p62-LC3 complex formation and polyubiquitination2018
- Author(s)
  Emi Aonuma, Yoichi Nibe, Hiroki Matsuda, Kana Otsubo, Chiaki Maeyashiki, Masanori Kobayashi, Yu Matsuzawa, Mamoru Watanabe, Shigeru Oshima
- Organizer
  Keystone Symposia - Ubiquitin Signaling
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04808
[Presentation] Novel polyubiquitin imaging system, PolyUb-FC, visualized atypical polyubiquitin chain in living cells2018
- Author(s)
  Nibe Y, Matsuda H, Aonuma E, Otsubo K, Maeyashiki C, Kobayashi M, Matsuzawa Y, Nakada S, Watanabe M, and Oshima S
- Organizer
  Keystone Symposia - Ubiquitin Signaling (A8)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15423
[Presentation] Necroptosis stimulation regulates SQSTM1/p62-LC3 complex formation and polyubiquitination.2018
- Author(s)
  Aonuma E, Nibe Y, Matsuda H, Otsubo K, Maeyashiki C, Kobayashi M, Matsuzawa Y, Watanabe M, and Oshima S
- Organizer
  Keystone Symposia - Ubiquitin Signaling (A8)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15423
[Presentation] Novel polyubiquitin imaging system, PolyUb-FC, visualized atypical polyubiquitin chain in living cells2018
- Author(s)
  Yoichi Nibe, Hiroki Matsuda, Emi Aonuma, Kana Otsubo, Chiaki Maeyashiki, Masanori Kobayashi, Yu Matsuzawa, Shinichiro Nakada, Mamoru Watanabe, Shigeru Oshima
- Organizer
  Keystone Symposia - Ubiquitin Signaling
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04808
[Presentation] 独自ポリユビキチン鎖可視化技術を用いた新規腸炎調節分子の同定2018
- Author(s)
  大島　茂、仁部洋一、松田浩紀、田村皓子、青沼映美、大坪加奈、渡辺　守
- Organizer
  第55回日本消化器免疫学会総会
- Data Source
  KAKENHI-PROJECT-18K07934
[Presentation] Novel polyubiquitin imaging reveals that atypical polyubiquitin contribute to autophagy via p622017
- Author(s)
  Nibe Y, Oshima S, Aonuma E, Matsuda H, Otsubo K, Maeyashiki C, Kobayashi M, Matsuzawa Y, Nakada S, Watanabe M.
- Organizer
  The 8th International Symposium on Autophagy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15423
[Presentation] TP53 mutation acquires higher malignant potential in human colon cancer cells2017
- Author(s)
  Watanabe S, Tsuchiya K, Shirasaki T, Hibiya S, Oshima S, Nakamura T, Nishimura R, Okamoto R, Watanabe M.
- Organizer
  UEGW2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04808
[Presentation] Novel polyubiquitin imaging reveals that atypical polyubiquitin contribute to autophagy2017
- Author(s)
  Nibe　Y, Oshima S, Aonuma E, Matsuda H, Otsubo K, Maeyashiki C, Kobayashia M, Matsuzawa Y , Nakada S, Watanabe M.
- Organizer
  GI research Academy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15423
[Presentation] HADHA, the alpha subunit of the mitochondrial trifunctional protein, is involved in long-chain fatty acid-induced autophagy in intestinal epithelial cells.2017
- Author(s)
  Otsubo K, Oshima S, Maeyashiki C, Aonuma E, Matsuda H, Kobayashi M, Nibe Y, Matsuzawa Y, Watanabe M
- Organizer
  The 8th International Symposium on Autophagy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15423
[Presentation] Atoh1 protein stabilization in colon tumor acquires the　morphological change to signet ring cell carcinoma with cancer stem cell enrichment.2016
- Author(s)
  Tsuchiya K, Hibiya S, Fukushima K, Shirasaki T, Oshima S, Okamoto R, Nakamura T, Watanabe M.
- Organizer
  APDW2016
- Place of Presentation
  Kobe convention center, KOBE（JAPAN）
- Year and Date
  2016-11-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04808
[Presentation] Construction of in vitro model of ulcerative colitis using mouse primary colonic organoid.2016
- Author(s)
  Hibiya S, Tsuchiya K, Watanabe S, Shirasaki T, Oshima S, Okamoto R, Nakamura T, Watanabe M.
- Organizer
  UEGW2016
- Place of Presentation
  Vienna（Austria）
- Year and Date
  2016-10-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04808
[Presentation] Mouse colonic organoid acquires wnt-independent survival property after long-term inflammation.2016
- Author(s)
  Shuji Hibiya, Kiichiro Tsuchiya, Tomoaki Shirasaki, Keita Fukushima, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe.
- Organizer
  AOCC2016
- Place of Presentation
  Kyoto International Conference Center, Kyoto（JAPAN）
- Year and Date
  2016-07-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04808
[Presentation] Atoh1 protein stabilization in colon tumor acquires the phenotype of signet ring cell carcinoma with cancer stem cell enrichment.2016
- Author(s)
  Kiichiro Tsuchiya, Shuji Hibiya, Keita Fukushima, Tomoaki Shirasaki, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe.
- Organizer
  AOCC2016
- Place of Presentation
  Kyoto International Conference Center, Kyoto（JAPAN）
- Year and Date
  2016-07-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04808
[Presentation] 長期炎症刺激による大腸上皮培養細胞の非可逆的NF κB シグナル活性.2016
- Author(s)
  日比谷秀爾、土屋輝一郎、白崎友彬、福島啓太、大島　茂、岡本隆一、中村哲也、渡辺　守.
- Organizer
  第102回日本消化器病学会総会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-15H04808
[Presentation] UBA52, ubiquitin hybrid ribisomal protein, regulates NF-κB signaling in colon cancer.2016
- Author(s)
  Masanori Kobayashi, Shigeru Oshima, Yoishi Nibe, Chiaki Maeyashiki, Mamoru Watanabe.
- Organizer
  DDW2016
- Place of Presentation
  San Diego（USA）
- Year and Date
  2016-05-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04808
[Presentation] Indentification of autophagic regulators as therapeutic targets in intestinal epithelial cells.2016
- Author(s)
  Chiaki Maeyashiki, Shigeru Oshima, Yoishi Nibe, Masanori Kobayashi, Mamoru Watanabe.
- Organizer
  DDW
- Place of Presentation
  San Diego (USA)
- Year and Date
  2016-05-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15423
[Presentation] Construction of in vitro model for inflammatory bowel disease using primary colonic organoid.2016
- Author(s)
  Syuji Hibiya, Kiichiro Tsuchiya, Tomoaki Shirasaki, Keita Fukushima, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe.
- Organizer
  DDW2016
- Place of Presentation
  San Diego（USA）
- Year and Date
  2016-05-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04808
[Presentation] A Crohn's Disease Susceptibility Gene A20 Regulates Autophagy Dynamics in CD4 T Cells2015
- Author(s)
  Yu Matsuzawa, Shigeru Oshima, Masanori Kobayashi, Yoichi Nibe, Chiaki Maeyashiki, Averil I. Ma, Mamoru Watanabe
- Organizer
  DDW(Digestive Disease Week)
- Place of Presentation
  Washington, DC（USA）
- Year and Date
  2015-05-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460946

1. WATANABE Mamoru (10175127)

# of Collaborated Projects: 3 results

# of Collaborated Products: 30 results
2. TSUCHIYA Kiichiro (40376786)

# of Collaborated Projects: 3 results

# of Collaborated Products: 22 results
3. OKADA Eriko (20376784)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. KUBOTA Daisuke (00376790)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 小林正典 (10825459)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 柿沼晴 (30372444)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. ONIZAWA Michio

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
8. OKAMOTO Ryuichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 11 results
9. ARAKI Akihiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. NAKADA Shinichiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. TORII Satoru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 中村哲也

# of Collaborated Projects: 0 results

# of Collaborated Products: 12 results
13. 永石宇治

# of Collaborated Projects: 0 results

# of Collaborated Products: 9 results
14. 大塚和朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 西村龍

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 日比谷秀爾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Oshima Shigeru 大島 茂

大島 茂 オオシマ シゲル

Research Projects

Research Products

Co-Researchers

ヒトiPS細胞由来胆管細胞培養系を用いた胆管癌における新規発癌機序の解明Ongoing

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分子応答解析に基づく肉芽腫形成モデルの樹立Principal InvestigatorOngoing

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Analysis of negative regulator of necroptosisPrincipal Investigator

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Inflammation related carcinogenesis by spiral cell transformation using in vitro chronic colitis model

Principal Investigator

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The mechanism of autoantibody production in IBDPrincipal Investigator

Principal Investigator

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慢性大腸炎粘膜局所T細胞の特異的増殖機構解明と新規治療法開発Principal Investigator

Principal Investigator

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Identification of the Notch signal in intestinal epithelial cells and the failure of the intestinal differentiation in chronic colitis.

Principal Investigator

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[Journal Article] TGF-β promotes fetal gene expression and cell migration velocity in a wound repair model of untransformed intestinal epithelial cells2020

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[Journal Article] High-fat diet-derived free fatty acids impair the intestinal immune system and increase sensitivity to intestinal epithelial damage.2020

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[Journal Article] T cells show amoeboid shape and frequent morphological change in vitro, and localize to small intestinal intraepithelial region in vivo.2020

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[Journal Article] Receotir-Interacting Protein Kinase3（RIPK3）inhibits autophagic flux furing necroptosis in intestinal epithelial cells.2020

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DOI

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[Journal Article] Ubiquitin D is up-regulated by synergy of Notch signaling and TNF-α in the inflamed intestinal epithelia of IBD patients.2019

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[Journal Article] Genetic and environmental factors drive personalized medicine for Crohn’s disease.2019

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[Journal Article] Contribution of ATOH1+ cells to the homeostasis, repair and tumorigenesis of the colonic epithelium.2018

Author(s)

Journal Title

Oshima Shigeru 大島茂

大島茂オオシマシゲル