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Watanabe Mamoru  渡辺 守

ORCIDConnect your ORCID iD *help
… Alternative Names

WATANABE Mamoru  渡辺 守

渡邉 守  ワタナベ マモル

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Researcher Number 10175127
Other IDs
External Links
Affiliation (Current) 2020: 東京医科歯科大学, 高等研究院, 特別栄誉教授
Affiliation (based on the past Project Information) *help 2019 – 2020: 東京医科歯科大学, 高等研究院, 特別栄誉教授
2014 – 2018: 東京医科歯科大学, 大学院医歯学総合研究科, 教授
2011 – 2016: 東京医科歯科大学, 医歯(薬)学総合研究科, 教授
2008 – 2013: 東京医科歯科大学, 医歯学総合研究科, 教授
2007 – 2012: Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 教授 … More
2011: 東京医科歯科大学, 医歯薬総合研究科, 教授
2010: 東京医科歯科大学, 大学院・医歯学総合研究科・消化器病態学, 教授
2010: 東京医科歯科大学, 大学院・医歯学総合研究科器官システム制御学系消化器病態学, 教授
2008: 東京医科歯科大学, 医歯(薬)学総合研究科, 教授
2008: 東京医科歯科大学, 大学院・医歯学総合研究科, 消化器病態学
2008: 東京医科歯科大学, 大学院・医歯学総合研究科・消化器病態学, 教授
2006: Tokyo Medical and Dental University, Department of Gastroenterology and Hepatology, Professor
2005 – 2006: 東京医科歯科大学, 大学院医歯学総合研究科, 教授
2000 – 2006: Tokyo Medical & Dental Univ., Dept.of Medicine, Professor, 医学部, 教授
2005: 東京医科歯科大学, 大学院医歯学総合研究所, 教授
2001 – 2005: 東京医科歯科大学, 大学院・医歯学総合研究科, 教授
2001 – 2002: 東京医科歯科大学, 大学院・医学部, 教授
2001: 東京医科歯科大学, 歯学部, 教授
1996: 慶応がんセンター, 診療部長
1993 – 1995: 慶應義塾大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Gastroenterology / Biological Sciences / Gastroenterology / Biomedical structure and function and related fields / Medium-sized Section 53:Organ-based internal medicine and related fields
Except Principal Investigator
Gastroenterology / Gastroenterology / Basic Section 53010:Gastroenterology-related / Biological Sciences / Immunology / Human pathology / Organ-based internal medicine and related fields / Environmental physiology(including physical medicine and nutritional physiology)
Keywords
Principal Investigator
IL-7 / 炎症性腸疾患 / 腸管上皮細胞 / 再生医療 / IL-7レセプター / 腸管免疫 / 慢性大腸炎 / 粘膜リンパ球 / 骨髄細胞 / 粘膜免疫 … More / Notchシグナル / Wntシグナル / HIV / 食物アレルギー / 転写因子 / Interferon Regulatory Factor (IRF) / 細胞内シグナル伝達 / Atoh1 / Wnt / Notch / ナノテクノロジー / transdifferentiation / 消化管粘膜免疫制御 / 免疫制御療法 / シグナル伝達 / 再生医学 / トランスレーショナルリサーチ / 腸上皮細胞 / 細胞治療 / エイズ / 細胞障害性T細胞 / CD4 / AIDS / regenerative medicine / intestinal epithelial cell / bone marrow cell / Hath1 / 磁性体 / 生体内組織染色 / 大腸癌 / ヘム / リポソーム / バイオマグネティックプローブ / 疾患診断システム / 画像情報 / アレルギー / アフィニティクロマトグラフィー / 腸内細菌 / 創薬 / 分化誘導療法 / 杯細胞分化 / 抗体療法 / 食餌アレルギー / SGビーズ「ミラクルビーズ」 / 生体受容体単離技術 / 5ASA / EspB / 消化管上皮細胞 / 病原性大腸菌 / 免疫学 / 生体分子 / Interferon Regulatory Factor(IRF) / 腸管再生 / 新規治療法 / 自然炎症 / 幹細胞移植 / 大腸炎創傷治癒 / 大腸上皮 / 組織幹細胞 / 体外培養技術 / 大腸炎 / 創傷治癒 / 大腸上皮幹細胞 / 細胞増殖機構 / 細胞分化機構 / 幹細胞培養 / オートファジー / 抗菌物質 / 内視鏡検体 / Lgr-5 / 腸管上皮 / バイオカプセル / 薬剤デリバリー / 初代培養法 / ヒト化マウス / 大腸移植 / 移植モデル / 発癌モデル / 腸内環境 / 共培養 / 幹細胞機能評価 / 疑似モデル構築 / 全身制御 / 腸管粘膜内リンパ球 / モノクローナル抗体 / 可溶性CD4 / 腸管上皮間リンパ球 / INTESTINAL MUCOSAL LYMPHOCYTE / CYTOTOXIC T LYMPHOCYTE / MONOCLONAL ANTIBODY / SOLUBLE CD4 / 経口免疫 / トランスジェニックマウス / コレラトキシン / SIV / oral Immunization / mucosal immunology / transgenic mouse / cytotoxic Tlymphcyte / Cholera toxin / 植物アレルギー / 骨髄幹細胞 / IL-7 receptor / mucosal jmmunity / chronic cohtis / food allergy / マイクロプラズマ / 低温プラズマ / 内視鏡 / 薬剤 / 生理活性物質 / 炎症 / 癌 / 低音プラズマ / 生理活性物資 / microplasma / low temperature plasma / endoscopy / drug / biological active substance / inflammation / cancer / 細胞分化 / 慢性腸炎 / 消化管粘膜免疫 / 粘膜IL-7 / IL-7レセプター機構 / 腸管上皮細胞分化 / サイトカイン / 骨髄細胞transdifferentiation / Il-7レセプター / mucosal immunity / cell differentiation / chronic colitis / transcriptional factor / 発生・分化 / ユビキチン-プロテアソーム / 腸管分化 / Hath-1 / Differentiation / Regenerative medicine / Translational research / Signal transduction / 幹細胞運命制御 / 大腸オルガノイド / 体性幹細胞 / 運命転換 / 臓器間制御 / ヒトオルガノイド / iPS細胞 / 複合臓器体外モデル … More
Except Principal Investigator
炎症性腸疾患 / IL-7 / 粘膜免疫 / 腸管免疫 / 再生医学 / inflammatory bowel disease / クローン病 / 幹細胞 / 発生・分化 / C型肝炎ウイルス / 肝疾患治療 / 大腸癌 / トランスジェニックマウス / 腸内細菌 / 新規治療法 / Atoh1 / 細胞移植 / 自然免疫 / サイトカイン / 慢性大腸炎 / 潰瘍性大腸炎 / Wntシグナル / 肝細胞 / オートファジー / IL-7レセプター / IRF-1 / 抗ウイルス療法 / musashi-1 / Crohn's disease / Th1 / Th2 / iPS細胞 / 杯細胞 / Notchシグナル / γδT細胞 / HCVレプリコン / HCV-JFH1培養系 / マウスモデル / Hath1 / FACS / メモリーT細胞 / C型肝炎 / NKT細胞 / インターフェロン / HCV / ノックアウトマウス / interleukin-7 / interleukin-7 receptor / mucosal immunology / knock-out mice / T lymphocytes / 樹状細胞 / レプリコン・システム / intestinal epithelial cell / small interfering RNA / HCV replicon system / ヒトiPS細胞 / 肝前駆細胞 / ジフテリア毒素 / Double Negative T細胞 / 慢性大腸炎モデル / 骨髄 / 白血球除去療法 / 肝幹細胞 / 無菌マウス / リンパ球 / 大腸上皮幹細胞 / 細胞増殖 / 細胞分化 / 小胞体ストレス / マッピング生検 / リンパ球動態制御 / TNFα / 移植 / 細胞・組織 / バルーン内視鏡 / transgenic mice / cytokine / Regeneration / cell transplantation / IgA / mucosal immunity / chronic colitis / NS5A蛋白 / apoptosis / NS5A / 食品 / 腸管上皮細胞 / レプリコン / 分子標的治療 / replicon / interferon / 慢性肝炎 / 肝癌 / innate immunity / 腸管上皮 / SP細胞 / 粘膜再生療法 / stem cell / regeneration of mucosa / IRF-2 / RNA interference / 遺伝子導入療法 / Crohn病 / 抗原 / dendritic cell / サイクロスポリンA / サイクロフィリン / Cyclosporin A / 臍帯血 / 細胞生物学 / 転写因子 / 腸管分化 / Notch / 自然免疫応答 / 肝臓病学 / 消化器病学 / 肝線維化 / 細胞間相互作用 / 肝星細胞 / 胆管細胞 / 肝幹/前駆細胞 / p53 / differential display / mRNA / 消化器疾患 / 遺伝子発現 / subtraction / 欠失地図 / ヒト第6番染色体 / drug delivery system / GFP / 腸管上皮細胞分化 / Interferon Reulatory Factor (IRF) / 免疫プロテアソーム / LMP7 / 腸管上皮間リンパ球 / 腸管上皮内リンパ球 / double negatuve T細胞 / suppression subtractive hybridization / 胃腺腫 / 胃癌 / 原発性胆汁性肝硬変 / ペプチド / ミラクルビーズ / マウス慢性大腸炎モデル / HVC-JFH1培養系 / 腸炎責任CD4 T 細胞 / 免疫記憶T 細胞 / 腸炎責任CD4 T細胞 / 免疫記憶T細胞 / 大腸炎 / 免疫記憶細胞 / 小腸 / 分化制御 / 標的遺伝子 / 加齢化免疫記憶CD4^+T細胞 / 老化CD4+T細胞 / 制御性T細胞 / 腸炎惹起生免疫記憶T細胞 / マウス大腸炎モデル / 加齢化免疫記憶T細胞 / 抑制性T細胞 / shRNA / マクロファージ / 細胞内寄生菌 / 間葉系幹細胞 / CD4^+ T細胞 / CD4^+T細胞 / CD4+T細胞 / CEACAM1 / シグナル伝達 / レプリコンシステム / HCV-Feoレプリコン / 小分子ライブラリー / 消化管上皮幹細胞 / ライブセルイメージング / 初代培養技術 / 細胞移植治療 / ライブイメージング / 初代培養 / 幹細胞移植 / 再生治療 / 注腸療法 / 腸管局所療法 / 抑制性CD4+CD25+T細胞 / CD4^+CD45RB^<high> T細胞移入大腸炎モデ / CD4^+CD45RB^<high>T細胞移入大腸炎モデル / Notchシグナル/初代培養/細胞移植治療 / 大腸上皮細胞 / プラークアッセイ / 細胞障害効果 / ヒト肝臓キメラマウス / RNAポリメラーゼ / 肝臓学 / 肝細胞移植 / CD13 / ダブルバルーン内視鏡 / DBE / 小腸生検 / 小腸培養 / 小腸内視鏡 / 生検検体 / IL-7R / 炎症性発癌 / MLCK / 炎症性腸管 / 慢性腸炎 / FTY720 / S1P受容体 / CD4 / 長期培養 / メモリー幹細胞 / GSK3 / 蛋白安定機構 / クロストーク / CD66a / NK細胞 / 治療抵抗性機序 / C型慢性肝炎 / インターロイキン6 / 治療抵抗性 / 肝発癌 / インターロイキン6 / コア変異株 / コア変異 / DAA製剤 / HCV / NS4B / IL28B / Cardif / IFNλ / IL-6 / 潜在的炎症 / 自己抗体 / 炎症 / 小腸がん / 網羅的遺伝子解析 / 下部消化管学 / 新規治療 / 下部消化管学(小腸、大腸) / インターフェロン誘導遺伝子 / GBP-1 / NS5B / Direct anti-viral agents / 薬剤耐性変異 / 次世代シークエンサー / γδ-T細胞 / 腸上皮細胞間T細胞 / キラーT細胞 / alyマウス / 腸管上皮の発達分化 / γδT細胞ノックアウトマウス / Intestinal intraepithelial gammadelta T cells, / Extratlymic development, / Germ-free mice, / Peyer^<, >s patches, / Intestinal epithelial cells. / 再生 / 骨粗鬆症 / 腫瘍血管 / 肝炎 / 心筋 / 骨髄間質 / 骨粗しょう症 / Osteoporisis / tumor angiogenesis / hetatitis / heart muscle / bone marrow stroma / diphteria toxin / リポソーム / 磁性体 / ヘム / プラズマ / 生体内組織染色 / バイオマグネティックプローブ / colon cancer / heme / liposome / biomagnetic probe / plasma / LHK antibody / in vivo tissue staining / 腫瘍壊死因子 / costimulatory molecule / 乳酸菌 / マウス実験腸炎モデル / OX40 / therapy / oral tolerance / commensal bacteria / costimulation / C型肝ウイルス / Interferon / TNF alpha / signal transduction / chronic hepatitis / 免疫学 / 腸内フローラ / 腸管上皮細胞T細胞 / 分泌型IgA抗体 / クリプトパッチ / 孤立リンパ小節 / 経口免疫寛容 / 腸管上皮細胞間T細胞 / 生体分子 / トランスレーショナルリサーチ / 腸管孤立リンパ小節 / 分泌型lgA抗体 / 腸内常在フローラ / インターロイキン15 / Heme oxygenase / 一酸化炭素 / dietary substances / immunology / intestinal flora / γδ T cells / intestinal T cells / secretory IgA antibody / cryptopatch / isolated lymphoid follicles / interferon regulatory factor 1 / interferon sensitivity determining region / interferon regulatory factor 3 / NS5A領域 / microarray / NF-KB / Hepatitis C Virus / NS5A protein / side population cell / 転写制御 / Interferon Regulatory Factor-1 / Interferon Regulatory Factor-2 / 腸管粘膜免疫制御 / 遺伝子発現制御 / Interferon Regulatory Factor / 粘膜内リンパ球 / IL-7受容体 / TSLP / IL-7 receptor / transcriptional regulation / 抗原特異性 / プロバイオテクス / 細胞移入 / 調節性T細胞 / 調節製T細胞 / 腸管粘膜免疫 / 単クローン / 自己免疫疾患 / inflammatory bowel diseases / murine model / Antigen-specific / Ulcerative colitis / Probiotics / Cell transfer / Transgenic mice / アデノウイルスベクター / hepatitis Ci virus / adenovirus vector / molecular targeted drug / antiviral therapy / gene therapy / natural killer T cell / antigen / β-catenin / WNT / レトロウイルスベクター / cyclophilin / 肝障害 / ヒト臍帯血由来細胞 / アルブミン / CD45 / linege marker / NOD / SCIDマウス / umbilical cord blood / hepatocytes / stem cells / liver injury / regenerative medicine / cell biology / Math1 / 杯細胞分化 / 蛋白分解 / Wnt signal / Transcription / Intestine / 炎症性 / 末梢血 / 腸 / 単球・マクロファージ / CD16 / ulcerative colitis / leukocytapheresis / 大腸上皮再生 / Chronic colitis / Stem Cell / 移植・再生医療 / 再生医療 / 傷害肝 / Regenerative medicine / Development & Differentiation / Transplantation / Stem cells / Umbilical cord blood / Cell therapy / Cell biology / Hepatocytes / サイクロスポリン / 発現ライブラリー / スクリーニング / HCVレプリコン・システム / siRNA / Hepatitis C virus / Interferon-stimulated genes / type-I interferon / high-throughput screening / macrophage / 1幹細胞可視化 / Lgr5プロモーター / 1幹細胞動態 / 炎症発癌 / 持続炎症刺激モデル / 持続炎症 / シグナルスパイラル / シグナル調節 / 上皮間リンパ球 / CD4-CD8αβ-T細胞 / 抗原提示細胞 / 抗原提示 / 肝細胞癌 / B型肝炎ウイルス / B型肝炎ウイルス / HD6 / 抗菌物質 / 粘膜バリア能 / 粘膜防御 / ナノネット / 小腸オルガノイド / 再燃予測 / 病態解明 / 炎症応答評価 / 分子マーカー / 免疫 / HBV / 発癌 / B型肝炎 / 臨床病態解析 / 非アルコール性脂肪性肝炎 / Matrix Metalloproteinase / 脂肪性肝炎 / 大腸腫瘍 / タンパク / 腸内環境 / 微生物 / 下部消化管 / 修飾後翻訳 / ゲノム編集 / 疾患モデル / 腸上皮形質 / 癌幹細胞 / スキルスがん / スキルス癌 / 腸上皮化生 / in vivo live imaging / intravital microscopy / photoconversion / 間葉系細胞 / 分化 Less
  • Research Projects

    (113 results)
  • Research Products

    (1,633 results)
  • Co-Researchers

    (141 People)
  •  ヒト体外複合臓器モデルによる生体維持機構解析Principal InvestigatorOngoing

    • Principal Investigator
      渡辺 守
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 53:Organ-based internal medicine and related fields
    • Research Institution
      Tokyo Medical and Dental University
  •  炎症性腸疾患発症におけるミオシン軽鎖キナーゼの役割Ongoing

    • Principal Investigator
      齊藤 詠子
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Tokyo Medical and Dental University
  •  タイトジャンクション制御による大腸腫瘍予防戦略の構築Ongoing

    • Principal Investigator
      福田 将義
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Tokyo Medical and Dental University
  •  炎症性腸疾患発症/持続/寛解/再燃時における腸炎惹起性メモリーT細胞動態の可視化Ongoing

    • Principal Investigator
      岡田 英理子
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Tokyo Medical and Dental University
  •  腸管上皮オートファジーによる新規免疫調節機構の解析とクローン病新規治療標的の抽出Ongoing

    • Principal Investigator
      長堀 正和
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Tokyo Medical and Dental University
  •  肝線維化治療の標的分子同定にむけたヒトiPS細胞由来肝組織様オルガノイドの開発Ongoing

    • Principal Investigator
      柿沼 晴
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Tokyo Medical and Dental University
  •  腸上皮化生を主眼とした消化器がんのスキルス化機構に関する研究Ongoing

    • Principal Investigator
      土屋 輝一郎
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Tokyo Medical and Dental University
  •  肝前駆細胞と肝間葉系細胞との相互作用機構の解明と抗線維化療法標的分子の探索Ongoing

    • Principal Investigator
      東 正新 (陳正新)
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Tokyo Medical and Dental University
  •  炎症性腸疾患発症過程の病態解析基盤樹立

    • Principal Investigator
      渡部 太郎
    • Project Period (FY)
      2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Tokyo Medical and Dental University
  •  Analysis of unconventional T cells as novel antigen presenting cellsOngoing

    • Principal Investigator
      根本 泰宏
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  クローン病再燃予測システムの開発Ongoing

    • Principal Investigator
      大塚 和朗
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  脂質応答性リンパ球の制御によるIBD新規治療法の開発Ongoing

    • Principal Investigator
      藤井 俊光
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  人工多能性幹細胞由来幹細胞を用いたHBV持続感染とHBV起因肝癌の分子機構の解明Ongoing

    • Principal Investigator
      新田 沙由梨
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  慢性肝疾患の線維化進展におけるMMP関連因子の機能解明と抗線維化療法の開発Ongoing

    • Principal Investigator
      井津井 康浩
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Identification of critical factor to generate human colon from small intestinePrincipal Investigator

    • Principal Investigator
      Watanabe Mamoru
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Research Field
      Biomedical structure and function and related fields
    • Research Institution
      Tokyo Medical and Dental University
  •  ユビキチン化蛋白の網羅的解析による炎症性発癌メカニズムの解明Ongoing

    • Principal Investigator
      鬼澤 道夫
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Research Field
      Organ-based internal medicine and related fields
    • Research Institution
      Tokyo Medical and Dental University
  •  ユビキチン修飾による腸管恒常性維持機構の解明Ongoing

    • Principal Investigator
      鬼澤 道夫
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Environmental physiology(including physical medicine and nutritional physiology)
    • Research Institution
      Fukushima Medical University
      Tokyo Medical and Dental University
  •  Analysis of intestinal CD4-CD8- double negative T cells

    • Principal Investigator
      OKADA Eriko
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Antigen processing in intestinal epithelial cells

    • Principal Investigator
      NAGAISHI Takashi
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  ウイルス性肝炎関連肝発癌における遺伝子変異と遺伝子発現制御機構の解析

    • Principal Investigator
      大岡 真也
    • Project Period (FY)
      2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  ナノネット粘膜防御によるクローン病新規治療開発

    • Principal Investigator
      荒木 昭博
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Analyses of molecular mechanisms underlying differentiation and proliferation of hepatic stem/progenitor cells for development of novel cell transplantation models

    • Principal Investigator
      KAKINUMA Sei
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Single cell imaging in human intestinal stem cell

    • Principal Investigator
      Tsuchiya Kiichiro
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Mucosal immune regulation by autophagy in intestinal epithelia

    • Principal Investigator
      NAGAISHI TAKASHI
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Inflammation related carcinogenesis by spiral cell transformation using in vitro chronic colitis model

    • Principal Investigator
      TSUCHIYA Kiichiro
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Research on molecular mechanisms underlying terminal differentiation of hepatic stem/progenitor cells via non-canonical Wnt signaling pathways

    • Principal Investigator
      AZUMA Seishin
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  The elucidation of homeostasis regulated by intestinal epithelial stem cellsPrincipal Investigator

    • Principal Investigator
      Watanabe Mamoru
    • Project Period (FY)
      2014 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Development of new treatment with trafficking modulation of colitogenic memory lymphocytes.

    • Principal Investigator
      FUJII TOSHIMITSU
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Analysis for viral factors and host factors influencing hepatitis C therapeutic effect.

    • Principal Investigator
      Itsui Yasuhiro
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  肝炎ウイルスに対する新規クラス抗ウイルス化合物の開発と作用機序の解析

    • Principal Investigator
      渡辺 貴子
    • Project Period (FY)
      2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Analysis of the pathogenesis in CD using mapping biopsy from entire small intestine

    • Principal Investigator
      Araki Akihiro
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  The mechanism of autoantibody production in IBD

    • Principal Investigator
      Oshima Shigeru
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Comprehensive gene analysis of small intestinal cancer tumor

    • Principal Investigator
      Ohtsuka Kazuo
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  The development of the disease model using humanized intestine in mice.Principal Investigator

    • Principal Investigator
      WATANABE Mamoru
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  複数の機能的マーカーを用いた炎症性腸疾患における腸炎惹起性メモリー幹細胞の探求

    • Principal Investigator
      根本 泰宏
    • Project Period (FY)
      2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  The analysis for the regulation of IEC differentiation by the switching mechanism of GSK3

    • Principal Investigator
      TSUCHIYA Kiichiro
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  CD66a-mediated crosstalk between intestinal epithelia and lymphocytes

    • Principal Investigator
      NAGAISHI Takashi
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Novel therapeutic strategy for Crohn's disease by targeting an NK cell subset

    • Principal Investigator
      NAGAHORI Masakazu
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Studies on molecular mechanisms regulating fate decision of hepatic stem cells and efficacy of hepatic stem cell transplantation

    • Principal Investigator
      KAKINUMA Sei
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Analysis of IL-6-mediated drug-resistance of hepatitis C virus infection

    • Principal Investigator
      NAKAGAWA Mina
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Study on establishment of experimental animal model for chimeric liver with hepatitis C virus infection using induced hepatocyte-like cells

    • Principal Investigator
      AZUMA Seishin
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Impaired host response and HCV disturbance of type I/III IFN signaling are closely associated with non-response to IFN-based anti-HCV treatment

    • Principal Investigator
      OOKA Shinya
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Development of the novel IBD treatment targeted S1P receptor

    • Principal Investigator
      FUJII TOSHIMITSU
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Development of a novel drug-delivery system by a bio-capsule that is built by primary intestinal epithelial cells.Principal Investigator

    • Principal Investigator
      WATANABE Mamoru
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  炎症性腸疾患における腸上皮自然炎症調節機構の破綻Principal Investigator

    • Principal Investigator
      渡辺 守
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University
  •  Designing and Developing Innovative Use of Newly Discovered Colonic Epithelial Culture Method Applicable to Clinical Medicine.Principal Investigator

    • Principal Investigator
      WATANABE Mamoru
    • Project Period (FY)
      2010 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  独自の培養技術を用いた大腸上皮細胞機能解析と腸炎細胞治療技術の基盤確立Principal Investigator

    • Principal Investigator
      渡辺 守
    • Project Period (FY)
      2010
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  The elucidation of functional regulation and pathogenesis in the entire human small intestine.

    • Principal Investigator
      ARAKI Akihiro
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  The functional analysis of IL-7 receptor in colitogenic memory Tcell.

    • Principal Investigator
      OKADA Eriko
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Identification of the inflammatory signaling in intestinal epithelial cells involved

    • Principal Investigator
      NAGANUMA Makoto
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  High-throughput screening of virus-and host-targeted suppressors of HCV infection

    • Principal Investigator
      SAKAMOTO Naoya
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Real-time imaging analysis of proliferation/differentiation of colonic epithelial cells in primary culture

    • Principal Investigator
      NAKAMURA Tetsuya
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Injection therapy of regulatory T cells into intestinal lumen

    • Principal Investigator
      TOTSUKA Teruji
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Crosstalk between Wnt and Notch signaling in colonic epithelium.

    • Principal Investigator
      SUZUKI Shinji
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Novel therapeutic strategy for ulcerative colitis by targeting NKT cells

    • Principal Investigator
      NAGAHORI Masakazu
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Development of plaque assay to isolate cytopathic HCV clones

    • Principal Investigator
      OOOKA Shinya
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Analysis on molecular mechanisms of liver reconstitution by transplanted hepatic cells

    • Principal Investigator
      AZUMA Seishin (CHEN Cheng-Hsin)
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Elucidation of intestinal mucosal immune system through the intracellular processing mechanisms of bacteria and its application for novel therapy of inflammatory bowel disease

    • Principal Investigator
      INOUE Nagamu
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
    • Research Field
      Gastroenterology
      Immunology
    • Research Institution
      Keio University
  •  Colitogenic memory T cells are maintained by IL-7-producing cells in bone marrow.

    • Principal Investigator
      NEMOTO Yasuhiro
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  CEACAM1 regulates the cytokine network in intestinal mucosa

    • Principal Investigator
      NAGAISHI Takashi
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Regeneration of intestinal mucosa and molecular mechanism of the failure of intestinal epithelial cells under intestinal inflammation.Principal Investigator

    • Principal Investigator
      WATANABE Mamoru
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Search for new classes of HCV therapeutics by large scale screening of antiviral compounds and host cellular factors

    • Principal Investigator
      SAKAMOTO Naoya
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Circulating colitogenic CD4+ memory T cells between bone marrow and intestine may be targets for the treatment of inflammatory bowel diseases

    • Principal Investigator
      KANAI Takanori
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Keio University
      Tokyo Medical and Dental University
  •  The development of regulatory T cell therapy using leukocyte apheresis for inflammatory bowel disease

    • Principal Investigator
      NAGAHORI Masakazu
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  The analysis of the regulation in intestinal differentiation by thecomprehensive search of Hath1 target genes

    • Principal Investigator
      TSUCHIYA Kiichirou
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Immunosenescent colitogenic CD4^+ T cells convert to regulatory cells and suppress colitis

    • Principal Investigator
      TOTUKA Teruji
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Research on transplantation of hepatic stem cells and development of experimental mouse models for hepatitis C virus

    • Principal Investigator
      CHEN Cheng-hsin
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Suppression subraction法による消化器癌の分子病態の解析

    • Principal Investigator
      SAKAMOTO Naoya
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University
  •  腸管粘膜局所IL-7ネットワーク制御応用による新規免疾統御療法開発Principal Investigator

    • Principal Investigator
      渡辺 守
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University
  •  腸内細菌フローラ由来菌体成分に対する新しい生体側受容体の単離

    • Principal Investigator
      宮田 達也
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Identification of the crosstalk between Notch signaling and Wnt signaling in the differentiation of the intestinal epithelial cells.Principal Investigator

    • Principal Investigator
      WATANABE Mamoru
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Clarification of the interaction between the differentiation and immune regulation of goblet cells by Math1.

    • Principal Investigator
      TSUCHIYA Kiichiro
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  The development of 2nd generated leukocytapheresis to remove phathological immune cells in inflammatory bowel diseases

    • Principal Investigator
      ARAKI Akihiro
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Identification of the Notch signal in intestinal epithelial cells and the failure of the intestinal differentiation in chronic colitis.

    • Principal Investigator
      OKADA Eriko
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Study on hepatic differentiation of mesenchymal stem cells derived from human umbilical cord blood, and cell therapy for liver disease by use of mesenchymal stem cells.

    • Principal Investigator
      CHEN Cheng-Hsin
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Comprehensive screening of host proteins that suppress replication of HCV replicon

    • Principal Investigator
      SAKAMOTO Naoya
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Development of novel therapy targeting innate immunity for Crohn's disease

    • Principal Investigator
      IWAO Yasushi
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      KEIO UNIVERSITY
  •  粘膜免疫の特殊性を応用した腸管免疫統御療法の開発Principal Investigator

    • Principal Investigator
      渡辺 守
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University
  •  腸管粘膜局所IL-7ネットワーク制御応用による新規免疫統御療法開発Principal Investigator

    • Principal Investigator
      渡辺 守
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University
  •  腸管上皮細胞の分化調節による局所免疫制御機構の解明と慢性大腸炎治療戦略への応用

    • Principal Investigator
      中村 哲也
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  超微小ビーズ担体を用いた食物アレルゲンに対する生体側受容体の単離Principal Investigator

    • Principal Investigator
      渡辺 守
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Identification of gastrointestinal epithelial stem cell and development of regeneration therapy for LBD

    • Principal Investigator
      HIBI Toshifumi
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Gastroenterology
    • Research Institution
      KEIO UNIVERSITY
  •  Suppression of hepatitis C virus replication by cyclosporine A

    • Principal Investigator
      OOOKA Shinya
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Identification of human cord blood-derived hepatic stem cells, and establishment of cell therapy for lethal liver disease

    • Principal Investigator
      KAKINUMA Sei
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      The University of Tokyo
      Tokyo Medical and Dental University
  •  粘膜免疫の特殊性を応用した腸管免疫統御療法の開発Principal Investigator

    • Principal Investigator
      渡辺 守
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University
  •  骨髄-腸上皮相互作用による腸管上皮幹細胞システム制御機構の解析Principal Investigator

    • Principal Investigator
      渡辺 守
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University
  •  Development of a novel therapy for the treatment of chronic colitis based on the manipulation of mucosal immune response and the clarification of tissue specific system for epithelial regeneration.Principal Investigator

    • Principal Investigator
      WATANABE Mamoru
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Establishment of transgenic mice that recognize bacteria specific antigen and develop spontaneous colitis under specific pathogen free condition.

    • Principal Investigator
      KANAI Takanori
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Therapeutic application of RNA interference to suppress hepatitis C virus replication

    • Principal Investigator
      SAKAMOTO Naoya
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Development of novel therapy targeting dendritic cells for Crohn's disease

    • Principal Investigator
      IWAO Yasushi
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Keio University
  •  消化管粘膜免疫の特殊性を応用した腸管免疫機構の統御療法Principal Investigator

    • Principal Investigator
      渡辺 守
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University
  •  超微小ビーズ担体を用いた食物抗原・ペプチドに対する生体側受容体の単離Principal Investigator

    • Principal Investigator
      渡辺 守
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  遺伝子組換えフローラ大腸菌含有ハードカプセルを用いた漫性大腸炎に対する治療戦略

    • Principal Investigator
      日比 紀文
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Keio University
  •  Analysis of anti-interferon mechanism by HCV NS5A protein using HCV replicon system

    • Principal Investigator
      ENOMOTO Nobuyuki
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      University of Yamanashi
      Tokyo Medical and Dental University
  •  Identification of gastrointestinal epithelial stem cell and development of regeneration therapy for IBD

    • Principal Investigator
      HIBI Toshifumi
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Keio University
  •  Elucidation of the regulatory mechanisms for mucosal immune response by mucosal IL-7/IL-7 receptor system

    • Principal Investigator
      NAKAMURA Tetsuya
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Suppression subtraction法による消化器疾患の分子病態解析

    • Principal Investigator
      ENOMOTO Nobuyuki
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University
  •  単クローン抗体を封入した病変部指向性磁性体による大腸疾患診断システムの開発Principal Investigator

    • Principal Investigator
      渡辺 守
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  炎症を発生母地とした大腸癌に関与する新規癌抑制遺伝子の単離

    • Principal Investigator
      HIBI Toshifumi
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Keio University
  •  Elucidation of the mechanism for regurating mucosal immune response and application for the treatment of chronic colitis and food allergy.Principal Investigator

    • Principal Investigator
      WATANABE Mamoru
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Application! Of low temperature microplasma to the treatment and diagnosis for gastrointestinal diseasePrincipal Investigator

    • Principal Investigator
      WATANABE Mamoru
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Establishment of a novel therapy of Inflammatory bowel disease by inducible oral tolerance

    • Principal Investigator
      KANAI Takanori
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Elucidation of the molecular mechanism of chronic hepatitis through the analysis of intracellular function of NS5A protein of hepatitis C virus

    • Principal Investigator
      KUROSAKI Masayuki
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  Investigation of immuno-regulatory competency of dietary substances and its application for our own beneficial ends

    • Principal Investigator
      ISHIKAWA Hiromichi
    • Project Period (FY)
      2001 – 2005
    • Research Category
      Grant-in-Aid for Creative Scientific Research
    • Research Institution
      Keio University
  •  Development of novel humanized-mice and application to regenerative medicine

    • Principal Investigator
      HATA Jun-ichi
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Human pathology
    • Research Institution
      National Research Institute for Child Health and Development
      Keio University
  •  New therapy targeting IL-7 receptor positive lymphocytes for chronic intestinal inflammation

    • Principal Investigator
      NAGANUMA Makoto
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Keio University
  •  Development of novel diagnostic device using lesion-orieinted biomagnetic probe

    • Principal Investigator
      HIBI Toshifumi
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Keio University
  •  New therapy for chronic intestinal inflammation by regulating mucosal immune responses

    • Principal Investigator
      HIBI Toshifumi
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Gastroenterology
    • Research Institution
      Keio University
  •  New therapy for intestinal inflammation by regulating mucosal immune responses

    • Principal Investigator
      HIBI Toshifumi
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (A).
    • Research Field
      Gastroenterology
    • Research Institution
      Keio University
  •  IL-7トランスジェニック/p53ノックアウトマウスにおける大腸癌発癌機構

    • Principal Investigator
      渡辺 憲明
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Kitasato Institute
  •  Induction of cytotoxic Tlymphocyters in the intestinal mucosa by oral immunization of SIV gag or env peptide conjugated with chorela toxinPrincipal Investigator

    • Principal Investigator
      HIBI Toshifumi, 渡辺 守
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Keio University
  •  Development and physiological role of gammadelta T cells.

    • Principal Investigator
      ISHIKAWA Hiromichi
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Keio University
  •  ACTIVE IMMUNE THERAPY FOR THE TREATMENT OF AIDSPrincipal Investigator

    • Principal Investigator
      WATANABE Mamoru
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      KEIO UNIVERSITY

All 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 Other

All Journal Article Presentation Book Patent

  • [Book] JMEDJ治療法便覧2016~私の治療~ 潰瘍性大腸炎2017

    • Author(s)
      藤井俊光、渡辺守
    • Publisher
      日本医事新報社
    • Data Source
      KAKENHI-PROJECT-26460963
  • [Book] Crohn’s Disease and Ulcerative Colitis: from Epidemiology and Immunology to a Rational Diagnostic and Therapeutic Approach2017

    • Author(s)
      Nagaishi T and Watanabe M
    • Publisher
      Springer, New York
    • ISBN
      9783319337012
    • Data Source
      KAKENHI-PROJECT-16H05286
  • [Book] Crohn’s Disease and Ulcerative Colitis: from Epidemiology and Immunology to a Rational Diagnostic and Therapeutic Approach2017

    • Author(s)
      Nagaishi T and Watanabe M
    • Publisher
      Springer, New York
    • ISBN
      9783319337012
    • Data Source
      KAKENHI-PROJECT-17K09372
  • [Book] Paradigm of T cell differentiation in IBD: Crohn's disease and ulcerative colitis. / Crohn's Disease and Ulcerative Colitis2016

    • Author(s)
      Nagaishi T,Watanabe M
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-26460963
  • [Book] 炎症性腸疾患―生物学的製剤の課題と展望 / 消化器疾患 最新の治療 2015-20162015

    • Author(s)
      藤井俊光、渡辺 守
    • Total Pages
      512
    • Publisher
      南江堂
    • Data Source
      KAKENHI-PROJECT-26460963
  • [Book] 2章 消化器疾患別Q&A 潰瘍性大腸炎、Crohn病 / 消化管疾患診療のギモン・シツモン・アンコモン2015

    • Author(s)
      藤井俊光、渡辺 守
    • Total Pages
      160
    • Publisher
      日本医事新報社
    • Data Source
      KAKENHI-PROJECT-26460963
  • [Book] 消化器疾患 最新の治療 2015-2016 (巻頭3. 炎症性腸疾患―生物学的製剤の課題と展望 Page12-17)2015

    • Author(s)
      藤井俊光、渡辺守
    • Total Pages
      512
    • Publisher
      南江堂
    • Data Source
      KAKENHI-PROJECT-26460963
  • [Book] 治療薬の使い方 コツと落とし穴 その他の治療「現在開発中の新規治療」 / チェックリストで分かる! IBD治療薬の選び方・使い方 重症度と患者背景から導く炎症性腸疾患の処方2015

    • Author(s)
      藤井俊光、渡辺 守
    • Total Pages
      262
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-26460963
  • [Book] これで納得!画像で見ぬく消化器疾患vol.3小腸2014

    • Author(s)
      渡辺守
    • Total Pages
      168
    • Publisher
      医学出版
    • Data Source
      KAKENHI-PROJECT-23590934
  • [Book] 実践!IBD診療2014

    • Author(s)
      藤井 俊光、渡辺 守
    • Total Pages
      224
    • Publisher
      医学出版
    • Data Source
      KAKENHI-PROJECT-23590934
  • [Book] GI Research2014

    • Author(s)
      渡辺 守
    • Total Pages
      2
    • Publisher
      先端医学社
    • Data Source
      KAKENHI-PROJECT-24590936
  • [Book] 実践!IBD診療2014

    • Author(s)
      渡辺守、藤井俊光
    • Total Pages
      224
    • Publisher
      医学出版
    • Data Source
      KAKENHI-PROJECT-23590934
  • [Book] 今日の治療指針20142014

    • Author(s)
      渡辺守
    • Total Pages
      2128
    • Publisher
      医学書院
    • Data Source
      KAKENHI-PROJECT-23590934
  • [Book] Intestine2014

    • Author(s)
      大塚和朗、渡辺大輔、小形典之、長堀正和、藤井俊光、齊藤詠子、和田祥城、荒木昭博、渡辺 守
    • Total Pages
      5
    • Publisher
      日本メディカルセンター
    • Data Source
      KAKENHI-PROJECT-24590937
  • [Book] IBD Research2014

    • Author(s)
      竹中健人、大塚和朗、北詰良雄、藤井俊光、齋藤詠子、長堀正和、松岡克善、藤岡友之、渡辺守
    • Total Pages
      8
    • Publisher
      先端医学社
    • Data Source
      KAKENHI-PROJECT-24590937
  • [Book] 実験医学2014

    • Author(s)
      渡辺 守、他
    • Total Pages
      6
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-24590936
  • [Book] 今日の治療指針20142014

    • Author(s)
      渡辺守、山口徹・北原光夫
    • Total Pages
      2128
    • Publisher
      医学書院
    • Data Source
      KAKENHI-PROJECT-23590934
  • [Book] 分子消化器病2014

    • Author(s)
      渡辺 守
    • Total Pages
      1
    • Publisher
      先端医学社
    • Data Source
      KAKENHI-PROJECT-24590936
  • [Book] 病態と治療戦略がみえる免疫・アレルギー疾患イラストレイテッド, 2013年臨床編II臓器特異的自己免疫疾患クローン病2013

    • Author(s)
      大島茂、藤井俊光、渡辺守
    • Total Pages
      359
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-23590934
  • [Book] 病態と治療戦略がみえる 免疫・アレルギー疾患イラストレイテッド2013

    • Author(s)
      大島 茂、藤井 俊光、渡辺 守
    • Total Pages
      359
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-23590934
  • [Book] 最新医学 68巻6月号2013

    • Author(s)
      永石 宇司、藤井 俊光、渡辺 守
    • Publisher
      最新医学社
    • Data Source
      KAKENHI-PROJECT-24590936
  • [Book] 最新医学 68巻6号2013

    • Author(s)
      永石宇司、藤井俊光、渡辺 守
    • Publisher
      最新医学社
    • Data Source
      KAKENHI-PROJECT-24590936
  • [Book] 消化器内科ーNon-canonical Wnt経路による肝幹/前駆細胞の増殖/分化の調節2013

    • Author(s)
      柿沼 晴、幾世橋 佳、渡辺 守
    • Total Pages
      5
    • Publisher
      科学評論社
    • Data Source
      KAKENHI-PROJECT-24590957
  • [Book] 臨床免疫・アレルギー科 57巻2012

    • Author(s)
      根本泰宏、渡辺 守
    • Publisher
      科学評論社
    • Data Source
      KAKENHI-PROJECT-24590933
  • [Book] Medical Practice2012

    • Author(s)
      長沼誠、渡辺 守
    • Total Pages
      5
    • Publisher
      文光堂
    • Data Source
      KAKENHI-PROJECT-22590696
  • [Book] Japanese Journal of Clinical Immunology2012

    • Author(s)
      長沼誠、渡辺 守、他
    • Publisher
      日本臨床免疫学会
    • Data Source
      KAKENHI-PROJECT-22590696
  • [Book] Intestine2012

    • Author(s)
      長沼誠、渡辺 守
    • Total Pages
      6
    • Publisher
      日本メディカルセンター
    • Data Source
      KAKENHI-PROJECT-22590696
  • [Book] G.I.Research 20巻2012

    • Author(s)
      根本泰宏、渡辺 守
    • Publisher
      先端医学社
    • Data Source
      KAKENHI-PROJECT-24590933
  • [Book] GI Research2012

    • Author(s)
      長堀正和、渡辺 守
    • Total Pages
      4
    • Publisher
      先端医学社
    • Data Source
      KAKENHI-PROJECT-24590937
  • [Book] GI Research2012

    • Author(s)
      鈴木雅博、永石宇司、渡辺 守
    • Publisher
      先端医学社
    • Data Source
      KAKENHI-PROJECT-24590937
  • [Book] G.I.Research2012

    • Author(s)
      鈴木雅博、永石宇司、渡辺 守
    • Publisher
      先端医学社
    • Data Source
      KAKENHI-PROJECT-22590696
  • [Book] INTESTINE Vol.162012

    • Author(s)
      根本泰宏、金井隆典、渡辺 守
    • Publisher
      日本メディカルセンター
    • Data Source
      KAKENHI-PROJECT-24590933
  • [Book] GI Research2012

    • Author(s)
      鈴木雅博、永石宇司、渡辺 守
    • Publisher
      先端医学社
    • Data Source
      KAKENHI-PROJECT-24590936
  • [Book] リンパ学 35巻2012

    • Author(s)
      根本泰宏、金井隆典、渡辺 守
    • Publisher
      日本リンパ学会
    • Data Source
      KAKENHI-PROJECT-24590933
  • [Book] 分子消化器病2012

    • Author(s)
      中村哲也、渡辺 守、他
    • Publisher
      先端医学社
    • Data Source
      KAKENHI-PROJECT-24590936
  • [Book] IBD炎症性腸疾患を究める2011

    • Author(s)
      渡辺守
    • Total Pages
      304
    • Publisher
      メジカルレビュー社
    • Data Source
      KAKENHI-PROJECT-23590934
  • [Book] Modern Physician2011

    • Author(s)
      永石宇司、山地統、渡辺守
    • Total Pages
      3
    • Publisher
      株式会社新興医学出版社
    • Data Source
      KAKENHI-PROJECT-22590696
  • [Book] Review of Gastroenterology & Clinical Gastroenterology and Hepatology2011

    • Author(s)
      永石宇司、渡辺守
    • Total Pages
      5
    • Publisher
      ヘスコインターナショナル
    • Data Source
      KAKENHI-PROJECT-22590696
  • [Book] iPS細胞とDirect Conversion (G.I.Research)2011

    • Author(s)
      柿沼晴、渡辺守
    • Total Pages
      619
    • Publisher
      先端医学社
    • Data Source
      KAKENHI-PROJECT-21590833
  • [Book] これでわかるIBD診療のすべて2011

    • Author(s)
      渡辺守
    • Total Pages
      140
    • Publisher
      南江堂
    • Data Source
      KAKENHI-PROJECT-23590934
  • [Book] 臨床検査増刊号2011

    • Author(s)
      鈴木雅博、永石宇司、渡辺守
    • Total Pages
      7
    • Publisher
      医学書院
    • Data Source
      KAKENHI-PROJECT-22590696
  • [Book] これでわかるIBD診療のすべて2011

    • Author(s)
      藤井俊光, 渡辺守
    • Publisher
      南江堂
    • Data Source
      KAKENHI-PROJECT-23590934
  • [Book] 実験医学増刊号:免疫記憶の制御と疾患治療2011

    • Author(s)
      根本泰宏、金井孝典、渡辺守
    • Total Pages
      7
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-22590695
  • [Book] 臨床消化器内科(pH依存型放出調節メサラジン製剤(アサコール))(薬の知識)252010

    • Author(s)
      長堀正和, 玄世鋒, 長超越, 渡辺守
    • Publisher
      日本メディカルセンター
    • Data Source
      KAKENHI-PROJECT-22590696
  • [Book] 臨床消化器内科(タクロリムス(プログラフ))252010

    • Author(s)
      長沼誠、長堀正和、渡辺守
    • Publisher
      日本メディカルセンター
    • Data Source
      KAKENHI-PROJECT-21590806
  • [Book] 炎症性腸疾患:腸管粘膜免疫の特殊性2010

    • Author(s)
      永石宇司、渡辺守
    • Publisher
      医学書院
    • Data Source
      KAKENHI-PROJECT-22590696
  • [Book] 胃と腸(Crohn病小腸病変に対する治療効果免疫調節薬の粘膜治癒効果)452010

    • Author(s)
      長沼越, 今枝博之, 緒方晴彦, 岩男泰, 日比紀文, 渡辺守
    • Publisher
      医学書院
    • Data Source
      KAKENHI-PROJECT-22590696
  • [Book] 臨床粘膜免疫学:潰瘍性大腸炎2010

    • Author(s)
      永石宇司、渡辺守
    • Publisher
      シナジー
    • Data Source
      KAKENHI-PUBLICLY-22117508
  • [Book] 分子標的薬 その作用機序と効果予測(肝細胞及び肝幹・前駆細胞移植におけるMatrix Metalloproteinaseの関与)2010

    • Author(s)
      柿沼晴, 坂本直哉, 渡辺守, 他, 分著(小俣政男編集)
    • Total Pages
      239
    • Publisher
      アークメデイア
    • Data Source
      KAKENHI-PROJECT-21590833
  • [Book] 臨床粘膜免疫学:潰瘍性大腸炎2010

    • Author(s)
      永石宇司、渡辺守
    • Publisher
      シナジー
    • Data Source
      KAKENHI-PROJECT-21590806
  • [Book] 炎症性腸疾患:腸管粘膜免疫の特殊性2010

    • Author(s)
      永石宇司、渡辺守
    • Publisher
      医学書院
    • Data Source
      KAKENHI-PROJECT-20590737
  • [Book] .臨床消化器内科(タクロリムス(プログラフ))252010

    • Author(s)
      長沼越, 長堀正和, 渡辺守
    • Publisher
      日本メディカルセンタ
    • Data Source
      KAKENHI-PROJECT-22590696
  • [Book] 臨床粘膜免疫学:潰瘍性大腸炎2010

    • Author(s)
      永石宇司、渡辺守
    • Publisher
      シナジー
    • Data Source
      KAKENHI-PROJECT-22590696
  • [Book] 炎症性腸疾患:腸管粘膜免疫の特殊性2010

    • Author(s)
      永石宇司、渡辺守
    • Publisher
      医学書院
    • Data Source
      KAKENHI-PUBLICLY-22117508
  • [Book] 炎症性腸疾患:腸管粘膜免疫の特殊性2010

    • Author(s)
      永石宇司、渡辺守
    • Publisher
      医学書院
    • Data Source
      KAKENHI-PROJECT-21590806
  • [Book] 日本消化器病学会雑誌(クローン病小腸病変の診断と治療)1072010

    • Author(s)
      長沼越, 玄世鋒, 渡辺守
    • Publisher
      日本消化器病学会雑誌
    • Data Source
      KAKENHI-PROJECT-22590696
  • [Book] 臨床粘膜免疫学:潰瘍性大腸炎2010

    • Author(s)
      永石宇司、渡辺守
    • Publisher
      シナジー
    • Data Source
      KAKENHI-PROJECT-20590737
  • [Book] 臨床消化器内科(【消化器疾患の画像診断<放射線・MRI・超音波>スタンダードから新しい診断技術】画像診断炎症性腸疾患に対するMR enterographyの有用性)252010

    • Author(s)
      玄世鋒, 北詰良雄, 長堀正和, 渡辺守
    • Publisher
      日本メディカルセンター
    • Data Source
      KAKENHI-PROJECT-21590806
  • [Book] 臨床消化器内科(pH依存型放出調節メサラジン製剤(アサコール))(薬の知識)252010

    • Author(s)
      長堀正和,玄世鋒, 長沼誠, 渡辺守
    • Publisher
      日本メディカルセンター
    • Data Source
      KAKENHI-PROJECT-21590806
  • [Book] 消化器内科(小腸炎症性腸疾患診断におけるカプセル内視鏡とバルーン内視鏡の有用性)502010

    • Author(s)
      長沼越, 渡辺守
    • Publisher
      科学評論社
    • Data Source
      KAKENHI-PROJECT-22590696
  • [Book] 消化器(消化管IBD治療における生物製剤の開発状況)(Annual Review)20102010

    • Author(s)
      長堀正和, 渡辺守
    • Publisher
      中外医学社
    • Data Source
      KAKENHI-PROJECT-21590806
  • [Book] 消化器疾患における自然免疫・獲得免疫のクロストーク慢性大腸炎の発症と維持におけるIL-7の役割2009

    • Author(s)
      戸塚輝治、金井隆典、渡辺守
    • Data Source
      KAKENHI-PROJECT-21590804
  • [Book] サイトカインと炎症性腸疾患・自己免疫疾患その病態における役割と治療展開炎症性腸疾患(解説)2009

    • Author(s)
      戸塚輝治、渡辺守
    • Data Source
      KAKENHI-PROJECT-21590804
  • [Book] 消化器と免疫2009

    • Author(s)
      根本泰宏、渡辺守, 他
    • Publisher
      マイライフ社
    • Data Source
      KAKENHI-PROJECT-20590736
  • [Book] Medicina 炎症性腸疾患の病態 潰瘍性大腸炎とCrohn病の危険因子を中心に2008

    • Author(s)
      長堀正和, 渡辺 守
    • Publisher
      医学書院
    • Data Source
      KAKENHI-PROJECT-19590716
  • [Book] セカンドオピニオン実践ガイドMedical Practice(臨時増刊号)「炎症性腸疾患診療の基本的流れ-治療指針に基づいた実地医療-」2007

    • Author(s)
      長堀正和、渡辺 守
    • Publisher
      文光堂
    • Data Source
      KAKENHI-PROJECT-19590716
  • [Book] 臨床消化器内科「特集炎症性腸疾患におけるAZA/6-MPの役割 AZA/6-MPの効果発現」2007

    • Author(s)
      長堀正和、久保田大輔、渡辺 守
    • Publisher
      日本メディカルセンター
    • Data Source
      KAKENHI-PROJECT-19590716
  • [Book] 消化器疾患の最新治療2005-20062006

    • Author(s)
      岡田英理子, 渡辺 守
    • Total Pages
      476
    • Publisher
      南江堂
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590624
  • [Book] 外科2004

    • Author(s)
      岡田英理子, 金井隆典, 渡辺守
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590627
  • [Journal Article] Establishment of a system to evaluate the therapeutic effect and the dynamics of an investigational drug on ulcerative colitis using human colonic organoids2019

    • Author(s)
      Nishimura R, Shirasaki T, Tsuchiya K, Miyake Y, Watanabe Y, Hibiya S, Watanabe S, Nakamura T, Watanabe M
    • Journal Title

      Journal of Gastroenterology

      Volume: in press

    • DOI

      10.1007/s00535-018-01540-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K19535, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-18H02791, KAKENHI-PROJECT-17H06654, KAKENHI-PROJECT-17K19513, KAKENHI-PROJECT-17K15930
  • [Journal Article] Impact of novel NS5A resistance-associated substitutions of hepatitis C virus detected in treatment-experienced patients.2019

    • Author(s)
      Nitta S, Asahina Y, Kato T, Tsuchiya J, Inoue-Shinomiya E, Sato A, Tsunoda T, Miyoshi M, Kawai-Kitahata F, Murakawa M, Itsui Y, Nakagawa M, Azuma S, Kakinuma S, Hikita H, Takehara T, Watanabe M.
    • Journal Title

      Scientific Report

      Volume: 9 Pages: 5722-5722

    • DOI

      10.1038/s41598-019-42114-z

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09407, KAKENHI-PROJECT-18K07964, KAKENHI-PROJECT-18H02790, KAKENHI-PROJECT-17K15931, KAKENHI-PROJECT-17K15932
  • [Journal Article] Indolent T cell lymphoproliferative disorder with villous atrophy in small intestinediagnosed by single-balloon enteroscopy.2019

    • Author(s)
      Takashi Nagaishi, Daiki Yamada, Kohei Suzuki, Ryosuke Fukuyo, Eiko Saito, Masayoshi Fukuda, Taro Watabe, Naoya Tsugawa, Kengo Takeuchi, Kouhei Yamamoto, Ayako Arai, Kazuo Ohtsuka, Mamoru Watanabe
    • Journal Title

      Clin J Gastroenterol.

      Volume: in press

    • DOI

      10.1007/s12328-019-00971-1

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09372, KAKENHI-PROJECT-16H05286
  • [Journal Article] Loss of Fibrocystin Promotes Interleukin-8-Dependent Proliferation and CTGF Production of Biliary Epithelium2019

    • Author(s)
      Tsunoda T, Kakinuma S, Miyoshi M, Kamiya A, Kaneko S, Sato A, Tsuchiya J, Nitta S, Kawai-Kitahata F, Murakawa M, Itsui Y, Nakagawa M, Azuma S, Sogo T, Komatsu H, Mukouchi R, Inui A, Fujisawa T, Nakauchi H, Asahina Y, Watanabe M.
    • Journal Title

      Journal of Hepatology

      Volume: 印刷中

    • DOI

      10.1016/j.jhep.2019.02.024

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09406, KAKENHI-PROJECT-17K09407, KAKENHI-PROJECT-18K07964, KAKENHI-PROJECT-17K19647, KAKENHI-PROJECT-16H05285, KAKENHI-PROJECT-18H02790, KAKENHI-PROJECT-17K15931, KAKENHI-PROJECT-17K15932
  • [Journal Article] Genetic and environmental factors drive personalized medicine for Crohn’s disease.2019

    • Author(s)
      Oshima Shigeru、Watanabe Mamoru
    • Journal Title

      J Clin Invest.

      Volume: 128 Pages: 4758-4760

    • DOI

      10.1172/jci124303

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-17K19675, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-17H04024, KAKENHI-PROJECT-17K19513
  • [Journal Article] TP53 mutation by CRISPR system enhances the malignant potential of colon cancer.2019

    • Author(s)
      Watanabe S, Tsuchiya K, Nishimura R, Shirasaki T, Katsukura N, Hibiya S, Okamoto R, Nakamura T, Watanabe M
    • Journal Title

      Mol Cancer Res.

      Volume: in press

    • DOI

      10.1158/1541-7786.mcr-18-1195

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-17K19513
  • [Journal Article] Diabetic retinopathy as a risk factor associated with the development of hepatocellular carcinoma in nonalcoholic fatty liver disease2019

    • Author(s)
      Azuma S, Asahina Y, Kakinuma S, Azuma K, Miyoshi M, Inoue E, Tsunoda T, Sato A, Kaneko S, Nagata H, Kawai-Kitahata F, Murakawa M, Nitta S, Itsui Y, Tomita M, Nakagawa M, Watanabe M.
    • Journal Title

      Digestic Disiease

      Volume: 37 Pages: 247-254

    • DOI

      10.1159/000493580

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09406, KAKENHI-PROJECT-17K09407, KAKENHI-PROJECT-18K07964, KAKENHI-PROJECT-17K19647, KAKENHI-PROJECT-16H05285, KAKENHI-PROJECT-18H02790, KAKENHI-PROJECT-17K15931, KAKENHI-PROJECT-17K15932
  • [Journal Article] Ubiquitin D is up-regulated by synergy of Notch signaling and TNF-α in the inflamed intestinal epithelia of IBD patients.2019

    • Author(s)
      Kawamoto Ami、Nagata Sayaka、Anzai Sho、Takahashi Junichi、Kawai Mao、Hama Minami、Nogawa Daichi、Yamamoto Kouhei、Kuno Reiko、Suzuki Kohei、Shimizu Hiromichi、Hiraguri Yui、Yui Shiro、Oshima Shigeru、Tsuchiya Kiichiro、Nakamura Tetsuya、Ohtsuka Kazuo、Kitagawa Masanobu、Okamoto Ryuichi、Watanabe Mamoru
    • Journal Title

      Journal of Crohn and Colitis

      Volume: 13 Pages: 495-509

    • DOI

      10.1093/ecco-jcc/jjy180

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09370, KAKENHI-PROJECT-18K07902, KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-17K19675, KAKENHI-PROJECT-18K19535, KAKENHI-PROJECT-18K15743, KAKENHI-PROJECT-18K15774, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-16H05284, KAKENHI-PROJECT-17H04024, KAKENHI-PROJECT-18H02791, KAKENHI-PROJECT-18H02867, KAKENHI-PROJECT-17K19513, KAKENHI-PROJECT-17K19674
  • [Journal Article] Association of serum interferon-λ3 levels with hepatocarcinogenesis in chronic hepatitis C patients treated with direct-acting antiviral agents.2019

    • Author(s)
      Emi Inoue-Shinomiya, Miyako Murakawa, Yasuhiro Asahina, Mina Nakagawa, Jun Tsuchiya, Ayako Sato, Tomoyuki Tsunoda, Masato Miyoshi, Sayuri Nitta, Fukiko Kawai-Kitahata, Yasuhiro Itsui, Seishin Azuma, Sei Kakinuma, Kazumoto Murata, Masashi Mizokami, Mamoru Watanabe.
    • Journal Title

      Hepatology Reserch

      Volume: 印刷中

    • DOI

      10.1111/hepr.13307

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09406, KAKENHI-PROJECT-17K09407, KAKENHI-PROJECT-17K09448, KAKENHI-PROJECT-18K07964, KAKENHI-PROJECT-17K19647, KAKENHI-PROJECT-16H05285, KAKENHI-PROJECT-18H02790, KAKENHI-PROJECT-17K15931, KAKENHI-PROJECT-17K15932
  • [Journal Article] LIM homeobox 2 promotes interaction between human iPS-derived hepatic progenitors and iPS-derived hepatic stellate-like cells2019

    • Author(s)
      Miyoshi M, Kakinuma S, Kamiya A, Tsunoda T, Tsuchiya J, Sato A, Kaneko S, Nitta S, Kawai-Kitahata F, Murakawa M, Itsui Y, Nakagawa M, Azuma S, Nakauchi H, Asahina Y, Watanabe M.
    • Journal Title

      Scientific Report

      Volume: 9 Pages: 2072-2072

    • DOI

      10.1038/s41598-018-37430-9

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09406, KAKENHI-PROJECT-17K09407, KAKENHI-PROJECT-18K07964, KAKENHI-PROJECT-17K19647, KAKENHI-PROJECT-16H05285, KAKENHI-PROJECT-18H02790, KAKENHI-PROJECT-17K15931, KAKENHI-PROJECT-17K15932
  • [Journal Article] Single cell analysis of Crohn’s disease patient-derived small intestinal organoids reveals disease activity-dependent modification of stem cell properties.2018

    • Author(s)
      Suzuki Kohei、Murano Tatsuro、Shimizu Hiromichi、Ito Go、Nakata Toru、Fujii Satoru、Ishibashi Fumiaki、Kawamoto Ami、Anzai Sho、Kuno Reiko、Kuwabara Konomi、Takahashi Junichi、Tsuchiya Kiichiro、Nakamura Tetsuya、Ohtsuka Kazuo、Watanabe Mamoru、Okamoto Ryuichi
    • Journal Title

      J Gastroenterol.

      Volume: 印刷中 Pages: 1035-1047

    • DOI

      10.1007/s00535-018-1437-3

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H05284, KAKENHI-PROJECT-16K09302, KAKENHI-PROJECT-17K09370, KAKENHI-PROJECT-18K07902, KAKENHI-PROJECT-17K19675, KAKENHI-PROJECT-18K19535, KAKENHI-PROJECT-18K15743, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-17H04024, KAKENHI-PROJECT-18H02791, KAKENHI-PROJECT-18H02867, KAKENHI-PROJECT-17K19513, KAKENHI-PROJECT-17K19674
  • [Journal Article] Utility of Magnetic Resonance Enterography For Small Bowel Endoscopic Healing in Patients With Crohn's Disease.2018

    • Author(s)
      Takenaka Kento、Ohtsuka Kazuo、Kitazume Yoshio、Matsuoka Katsuyoshi、Nagahori Masakazu、Fujii Toshimitsu、Saito Eiko、Kimura Maiko、Fujioka Tomoyuki、Watanabe Mamoru
    • Journal Title

      Am J Gastroenterol.

      Volume: 113 Pages: 283-294

    • DOI

      10.1038/ajg.2017.464

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09370, KAKENHI-PROJECT-17K09372
  • [Journal Article] Novel polyubiquitin imaging system, PolyUb-FC, reveals that K33-linked polyubiquitin is recruited by SQSTM1/p62.2018

    • Author(s)
      Yoichi Nibe, Shigeru Oshima, Masanori Kobayashi, Chiaki Maeyashiki, Yu Matsuzawa, Kana Otsubo, Hiroki Matsuda, Emi Aonuma, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Shinichiro Nakada, Mamoru Watanabe
    • Journal Title

      Autophagy

      Volume: 22 Pages: 347-358

    • DOI

      10.1080/15548627.2017.1407889

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09372, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H05284, KAKENHI-PROJECT-16H05286, KAKENHI-PROJECT-16K15423, KAKENHI-PROJECT-17K19675, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-17H04024, KAKENHI-PROJECT-17K19513, KAKENHI-PROJECT-26241014
  • [Journal Article] 小腸病変の評価法:内視鏡とほかのモダリティーの比較2018

    • Author(s)
      竹中健人、大塚和朗、鈴木康平、勝倉暢洋、福田将義、藤井俊光、齊藤詠子、本林麻衣子、松岡克善、長堀正和、北詰良雄、藤岡友之、渡辺 守
    • Journal Title

      胃と腸

      Volume: 53 Pages: 203-210

    • Data Source
      KAKENHI-PROJECT-17K09372
  • [Journal Article] Contribution of ATOH1+ cells to the homeostasis, repair and tumorigenesis of the colonic epithelium.2018

    • Author(s)
      Ishibashi Fumiaki、Shimizu Hiromichi、Nakata Toru、Fujii Satoru、Suzuki Kohei、Kawamoto Ami、Anzai Sho、Kuno Reiko、Nagata Sayaka、Ito Go、Murano Tatsuro、Mizutani Tomohiro、Oshima Shigeru、Tsuchiya Kiichiro、Nakamura Tetsuya、Watanabe Mamoru、Okamoto Ryuichi
    • Journal Title

      Stem Cell Rep.

      Volume: 10 Pages: 27-42

    • DOI

      10.1016/j.stemcr.2017.11.006

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K19674, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H05284, KAKENHI-PROJECT-17K19675, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-17H04024, KAKENHI-PROJECT-17K19513
  • [Journal Article] B cell activation in the cecal patches during the development of an experimental colitis model2018

    • Author(s)
      Taro Watabe, Takashi Nagaishi, Naoya Tsugawa, Yudai Kojima, Nisha Jose, Akinori Hosoya, Michio Onizawa, Yasuhiro Nemoto, Shigeru Oshima, Tetsuya Nakamura, Hajime Karasuyama, Takahiro Adachi, Mamoru Watanabe
    • Journal Title

      Biochem Biophys res Commun.

      Volume: 496 Pages: 367-373

    • DOI

      10.1016/j.bbrc.2018.01.053

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09372, KAKENHI-PROJECT-17K19675, KAKENHI-PROJECT-15H05786, KAKENHI-PROJECT-16H05286, KAKENHI-PROJECT-17H04024, KAKENHI-PROJECT-15K08526, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-18K07997, KAKENHI-PROJECT-17K19513, KAKENHI-PROJECT-17K19674
  • [Journal Article] 免疫グロブリンAによる腸内細菌叢調節と腸管粘膜防御の再検証.2018

    • Author(s)
      津川直也、永石宇司、渡辺 守
    • Journal Title

      消化器と免疫 News letter

      Volume: 18 Pages: 1-1

    • Data Source
      KAKENHI-PROJECT-16H05286
  • [Journal Article] 特集Ⅰ 潰瘍性大腸炎-診断治療のアップデート 潰瘍性大腸炎の病因・疫学2018

    • Author(s)
      藤井俊光、渡辺 守
    • Journal Title

      消化器・肝臓内科

      Volume: 3 Pages: 1-7

    • Data Source
      KAKENHI-PROJECT-17K09372
  • [Journal Article] Prediction of disease activity of Crohn's disease through fecal calprotectin evaluated by balloon‐assisted endoscopy.2018

    • Author(s)
      Iwamoto Fumihiko、Matsuoka Katsuyoshi、Motobayashi Maiko、Takenaka Kento、Kuno Toru、Tanaka Keisuke、Tsukui Yuya、Kobayashi Shoji、Yoshida Takashi、Fujii Toshimitsu、Saito Eiko、Yamaguchi Tatsuya、Nagahori Masakazu、Sato Tadashi、Ohtsuka Kazuo、Enomoto Nobuyuki、Watanabe Mamoru
    • Journal Title

      J Gastroenterol Hepatol.

      Volume: 33 Pages: 1984-1989

    • DOI

      10.1111/jgh.14310

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09370, KAKENHI-PROJECT-17K09372, KAKENHI-PROJECT-18K07902
  • [Journal Article] Predictors of mucosal healing during induction therapy in patients with acute moderate-to-severe ulcerative colitis.2018

    • Author(s)
      Motobayashi Maiko、Matsuoka Katsuyoshi、Takenaka Kento、Fujii Toshimitsu、Nagahori Masakazu、Ohtsuka Kazuo、Iwamoto Fumihiko、Tsuchiya Kiichiro、Negi Mariko、Eishi Yoshinobu、Watanabe Mamoru
    • Journal Title

      Gastroenterol Hepatol.

      Volume: in press

    • DOI

      10.1111/jgh.14565

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09370, KAKENHI-PROJECT-17K09372, KAKENHI-PROJECT-18K07902, KAKENHI-PROJECT-18K19535, KAKENHI-PROJECT-18H02791
  • [Journal Article] 【特集】クローン病の最新薬物療法  クローン病のステロイド治療  ープレドニゾロン、ブデソニドの使い方2018

    • Author(s)
      藤井俊光、渡辺 守
    • Journal Title

      消化器の臨床

      Volume: 21 Pages: 19-26

    • Data Source
      KAKENHI-PROJECT-17K09372
  • [Journal Article] Indispensable role of Notch ligand-dependent signaling in the proliferation and stem cell niche maintenance of APC-deficient intestinal tumors.2017

    • Author(s)
      Nakata T, Shimizu H, Nagata S, Ito G, Fujii S, Suzuki K, Kawamoto A, Ishibashi F, Kuno R, Anzai S, Murano T, Mizutani T, Oshima S, Tsuchiya K, Nakamura T, Hozumi K, Watanabe M, Okamoto R
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 482 Pages: 1296-1303

    • DOI

      10.1016/j.bbrc.2016.12.031

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H05284
  • [Journal Article] IL-7 Biology- IL-7による腸管粘膜の免疫調節と大腸炎.2017

    • Author(s)
      永石宇司、渡辺 守
    • Journal Title

      医学のあゆみ.

      Volume: 261 Pages: 1083-1087

    • Data Source
      KAKENHI-PROJECT-17K09372
  • [Journal Article] クローン病感受性遺伝子 ”TNFAIP3・XIAP遺伝子”.2017

    • Author(s)
      鬼沢道夫、永石宇司、浅川剛人、南舘 愛、渡辺 守
    • Journal Title

      臨床免疫・アレルギー科.

      Volume: 68 Pages: 351-356

    • Data Source
      KAKENHI-PROJECT-17K09372
  • [Journal Article] Data showing proliferation and differentiation of intestinal epithelial cells under targeted depletion of Notch ligands in mouse intestine.2017

    • Author(s)
      Nakata T, Shimizu H, Nagata S, Ito G, Fujii S, Suzuki K, Kawamoto A, Ishibashi F, Kuno R, Anzai S, Murano T, Mizutani T, Oshima S, Tsuchiya K, Nakamura T, Hozumi K, Watanabe M, Okamoto R
    • Journal Title

      Data in Brief

      Volume: 10 Pages: 551-556

    • DOI

      10.1016/j.dib.2016.12.045

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H05284
  • [Journal Article] Effect of interferon-based and -free therapy on early occurrence and recurrence of hepatocellular carcinoma in chronic hepatitis C2017

    • Author(s)
      Nagata H, Nakagawa M, Asahina Y, Sato A, Asano Y, Tsunoda T, Miyoshi M, Kaneko S, Otani S, Kawai-Kitahata F, Murakawa M, Nitta S, Itsui Y, Azuma S, Kakinuma S, Nouchi T, Sakai H, Tomita M, Watanabe M
    • Journal Title

      Journal of Hepatology

      Volume: 67 Pages: 933-939

    • DOI

      10.1016/j.jhep.2017.05.028

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09406, KAKENHI-PROJECT-17K09407, KAKENHI-PROJECT-17K19647, KAKENHI-PROJECT-17K15931, KAKENHI-PROJECT-17K15932, KAKENHI-PROJECT-16H05285, KAKENHI-PROJECT-17H06655, KAKENHI-PROJECT-15K08988, KAKENHI-PROJECT-15K08989
  • [Journal Article] Magnetic resonance evaluation for small bowel strictures in Crohn's disease: comparison with balloon enteroscopy.2017

    • Author(s)
      Kento Takenaka, Kazuo Ohtsuka, Yoshio Kitazume, Katsuyoshi Matsuoka, Toshimitsu Fujii, Masakazu Nagahori, Maiko Kimura, Tomoyuki Fujioka, Akihiro Araki, Mamoru Watanabe.
    • Journal Title

      J Gastroenterol.

      Volume: 52 Pages: 879-888

    • DOI

      10.1007/s00535-016-1284-z

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K09302, KAKENHI-PROJECT-17K09372
  • [Journal Article] Long-term Inflammation Transforms Intestinal Epithelial Cells of Colonic Organoids2017

    • Author(s)
      Hibiya S, Tsuchiya K, Hayashi R, Horita N, Watanabe S, Shirasaki T, Nishimura R, Kimura N, Nishimura T, Gotoh N, Oshima S, Okamoto R, Nakamura T, Watanabe M
    • Journal Title

      Journal of Crohn's and Colitis

      Volume: 61 Pages: 621-630

    • DOI

      10.1093/ecco-jcc/jjw186

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H06770, KAKENHI-PROJECT-15K15287, KAKENHI-PROJECT-17K15930, KAKENHI-PROJECT-17H06654, KAKENHI-PROJECT-16K09302
  • [Journal Article] Distinct intestinal adaptation for vitamin B12 and bile acid absorption revealed in a new mouse model of massive ileocecal resection2017

    • Author(s)
      Matsumoto Y, Mochizuki W, Akiyama S, Matsumoto T, Nozaki K, Watanabe M, Nakamura T
    • Journal Title

      Biology Open

      Volume: 15 Pages: 1364-1374

    • DOI

      10.1242/bio.024927

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K19513, KAKENHI-PROJECT-17K19674, KAKENHI-PROJECT-26221307
  • [Journal Article] ITPA gene variation and ribavirin-induced anemia in patients with genotype 2 chronic hepatitis C treated with sofosbuvir plus ribavirin2017

    • Author(s)
      Murakawa M, Asahina Y, Nagata H, Nakagawa M, Kakinuma S, Nitta S, Kawai-Kitahata F, Otani S, Kaneko S, Miyoshi M, Tsunoda T, Asano Y, Sato A, Itsui Y, Azuma S, Nouchi T, Furumoto Y, Asano T, Chuganji Y, Tohda S, Watanabe M.
    • Journal Title

      Hepatol Res.

      Volume: 印刷中 Pages: 1212-1218

    • DOI

      10.1111/hepr.12867

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05285, KAKENHI-PROJECT-15K15285, KAKENHI-PROJECT-15K19316, KAKENHI-PROJECT-17K09406, KAKENHI-PROJECT-17K09407, KAKENHI-PROJECT-17K19647, KAKENHI-PROJECT-17K15931, KAKENHI-PROJECT-17K15932, KAKENHI-PROJECT-17H06655, KAKENHI-PROJECT-15K08988, KAKENHI-PROJECT-15K08989
  • [Journal Article] クローン病感受性遺伝子 ”TNFAIP3・XIAP遺伝子”.2017

    • Author(s)
      鬼沢道夫、永石宇司、浅川剛人、南舘 愛、渡辺 守
    • Journal Title

      臨床免疫・アレルギー科.

      Volume: 68 Pages: 351-356

    • Data Source
      KAKENHI-PROJECT-16H05286
  • [Journal Article] <i>CCN3</i> Expression Marks a Sulfomucin-nonproducing Unique Subset of Colonic Goblet Cells in Mice2017

    • Author(s)
      Akiyama S, Mochizuki W, Nibe Y, Matsumoto Y, Sakamoto K, Oshima S, Watanabe M, Nakamura T
    • Journal Title

      ACTA HISTOCHEMICA ET CYTOCHEMICA

      Volume: 50 Issue: 6 Pages: 159-168

    • DOI

      10.1267/ahc.17027

    • NAID

      130006285159

    • ISSN
      0044-5991, 1347-5800
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K19513, KAKENHI-PROJECT-26221307
  • [Journal Article] Caudal type homeobox 2 expression induced by leukocytapheresis might be associated with mucosal healing in ulcerative colitis2017

    • Author(s)
      Tsuchiya K, Hayashi R, Fukushima K, Hibiya S, Horita N, Negi M, Itoh E, Akashi T, Eishi Y, Motoya S, Takeuchi Y, Kunisaki R, Fukunaga K, Nakamura S, Yoshimura N, Takazoe M, Iizuka B, Suzuki Y, Nagahori M, Watanabe M
    • Journal Title

      Journal of Gastroenterology and Hepatology

      Volume: 61 Pages: 1032-1039

    • DOI

      10.1111/jgh.13645

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-17H06654
  • [Journal Article] Endoscopic features and genetic background of inflammatory bowel disease complicated with Takayasu arteritis2017

    • Author(s)
      Akiyama S, Fujii T, Matsuoka K, Yusuke E, Negi M, Takenaka K, Nagahori M, Ohtsuka K, Isobe M, Watanabe M.
    • Journal Title

      Journal of Gastroenterology and Hepatology

      Volume: 32 Pages: 1011-1017

    • DOI

      10.1111/jgh.13640

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26460963, KAKENHI-PROJECT-26670399, KAKENHI-PROJECT-17K09370, KAKENHI-PROJECT-17K09372
  • [Journal Article] IL-7による腸管粘膜の免疫調節と大腸炎.2017

    • Author(s)
      永石宇司、渡辺 守
    • Journal Title

      医学のあゆみ.

      Volume: 261 Pages: 1083-1087

    • Data Source
      KAKENHI-PROJECT-16H05286
  • [Journal Article] HADHA, the alpha subunit of the mitochondrial trifunctional protein, is involved in long-chain fatty acid-induced autophagy in intestinal epithelial cells.2017

    • Author(s)
      Maeyashiki C, Oshima S, Otsubo K, Kobayashi M, Nibe Y, Matsuzawa Y, Onizawa M, Nemoto Y, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Watanabe M
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 484 Pages: 636-641

    • DOI

      10.1016/j.bbrc.2017.01.159

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H05286, KAKENHI-PROJECT-16H06771, KAKENHI-PROJECT-15K15288, KAKENHI-PROJECT-16K15423
  • [Journal Article] Regulation of intestinal homeostasis by the ulcerative colitis-associated gene RNF1862017

    • Author(s)
      Fujimoto K, Kinoshita M, Tanaka H, Okuzaki D, Shimada Y, Kayama H, Okumura R, Furuta Y, Narazaki M, Tamura A, Hatakeyama S, Ikawa M, Tsuchiya K, Watanabe M, Kumanogoh A, Tsukita S, Takeda K
    • Journal Title

      Mucosal Immunology

      Volume: 10 Pages: 446-445

    • DOI

      10.1038/mi.2016.58

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H02511, KAKENHI-PROJECT-15H04690, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-15K15152, KAKENHI-ORGANIZER-25112001, KAKENHI-PLANNED-24113002
  • [Journal Article] MKL1 expressed in macrophages contributes to the development of murine colitis2017

    • Author(s)
      Jianbo An, Takashi Nagaishi, Taro Watabe, Taeko K. Naruse, Mamoru Watanabe, Akinori Kimura
    • Journal Title

      Scientific Reports

      Volume: 7 Pages: 13650-13650

    • DOI

      10.1038/s41598-017-13629-0

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09372, KAKENHI-PROJECT-16H05286, KAKENHI-PROJECT-16H05296, KAKENHI-PROJECT-15K08328
  • [Journal Article] Magnetic resonance evaluation for small bowel strictures in Crohn's disease: comparison with balloon enteroscopy.2017

    • Author(s)
      Takenaka K, Ohtsuka K, Kitazume Y, Matsuoka K, Fujii T, Nagahori M, Kimura M, Fujioka T, Araki A, Watanabe M.
    • Journal Title

      J Gastroenterol.

      Volume: 印刷中

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26460963
  • [Journal Article] Hepatic IFNL4 expression is associated with non-response to interferon-based therapy through the regulation of basal interferon-stimulated gene expression in chronic hepatitis C patients2017

    • Author(s)
      Murakawa M, Asahina Y, Kawai-Kitahata F, Nakagawa M, Nitta S, Otani S, Nagata H, Kaneko S, Asano Y, Tsunoda T, Miyoshi M, Itsui Y, Azuma S, Kakinuma S, Tanaka Y, Iijima S, Tsuchiya K, Izumi N, Tohda S, Watanabe M.
    • Journal Title

      Journal of Medical Virology

      Volume: in press Pages: 1241-1247

    • DOI

      10.1002/jmv.24763

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09345, KAKENHI-PROJECT-26460987, KAKENHI-PROJECT-15K15285, KAKENHI-PROJECT-15K19316, KAKENHI-PROJECT-16K09366, KAKENHI-PROJECT-17K09406, KAKENHI-PROJECT-17K09407, KAKENHI-PROJECT-17K19647, KAKENHI-PROJECT-17K15931, KAKENHI-PROJECT-17K15932, KAKENHI-PROJECT-16H05285, KAKENHI-PROJECT-17H06655, KAKENHI-PROJECT-15K08988, KAKENHI-PROJECT-15K08989
  • [Journal Article] Morphogenetic Protein-4 Modulates Proliferation and Terminal Differentiation of Fetal Hepatic Stem/Progenitor Cells.2017

    • Author(s)
      Goto F, Kakinuma S, Miyoshi M, Tsunoda T, Kaneko S, Sato A, Asano Y, Otani S, Azuma S, Nagata H, Kawai-Kitahata F, Murakawa M, Nitta S, Itsui Y, Nakagawa M, Asahina Y, Watanabe M.
    • Journal Title

      Hepatol Res.

      Volume: 印刷中 Pages: 941-952

    • DOI

      10.1111/hepr.12823

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05285, KAKENHI-PROJECT-16K09345, KAKENHI-PROJECT-26460987, KAKENHI-PROJECT-15K15285, KAKENHI-PROJECT-15K19316, KAKENHI-PROJECT-15K08988, KAKENHI-PROJECT-15K08989, KAKENHI-PROJECT-17K19647, KAKENHI-PROJECT-17K15931
  • [Journal Article] Retinol promotes in vitro growth of proximal colon orgnaoids through a retinoic acid-independent mechanism.2016

    • Author(s)
      Matsumoto T, Mochizuki W, Nibe Y, Akiyama S, Matsumoto Y, Nozaki K, Fukuda M, Hayashi A, Mizutani T, Oshima S, Watanabe M, Nakamura T
    • Journal Title

      PLoS One.

      Volume: 11

    • DOI

      10.1371/journal.pone.0162049

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26221307
  • [Journal Article] Serial measurement of Wisteria floribunda agglutinin positive Mac-2-binding protein is useful for predicting liver fibrosis and the development of hepatocellular carcinoma in chronic hepatitis C patients treated with IFN-based and IFN-free therapy2016

    • Author(s)
      Nagata H, Nakagawa M, Nishimura-Sakurai Y, Asano Y, Tsunoda T, Miyoshi M, Kaneko S, Goto F, Otani S, Kawai-Kitahata F, Murakawa M, Nitta S, Itsui Y, Seishin Azuma S, Kakinuma S, Tojo N, Tohda T, Asahina Y, Watanabe M, the Ochanomizu Liver Conference Study Group.
    • Journal Title

      Hepatol Int.

      Volume: 10 Pages: 956-964

    • DOI

      10.1007/s12072-016-9754-1

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-16H05285, KAKENHI-PROJECT-16K09345, KAKENHI-PROJECT-26460987, KAKENHI-PROJECT-15K15285, KAKENHI-PROJECT-15K08988, KAKENHI-PROJECT-15K08989
  • [Journal Article] Matrix metalloproteinase-14 mediates formation of bile ducts and hepatic maturation of fetal hepatic progenitor cells.2016

    • Author(s)
      Otani S, Kakinuma S, Kamiya A, Goto F, Kaneko S, Miyoshi M, Tsunoda T, Asano Y, Kawai-Kitahata F, Nitta S, Nakata T, Okamoto R, Itsui Y, Nakagawa M, Azuma S, Asahina Y, Yamaguchi T, Koshikawa N, Seiki M, Nakauchi H, Watanabe M.
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 469 Pages: 1062-1068

    • DOI

      10.1016/j.bbrc.2015.12.105

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08988, KAKENHI-PROJECT-26460358, KAKENHI-PROJECT-26460987, KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-25293169, KAKENHI-PROJECT-25293170, KAKENHI-PROJECT-15K08989, KAKENHI-PROJECT-16H05285, KAKENHI-PROJECT-15K15285
  • [Journal Article] The ubiquitin hybrid gene UBA52 regulates ubiquitination of ribosome and sustains embryonic development.2016

    • Author(s)
      Kobayashi M, Oshima S, Maeyashiki C, Nibe Y, Otsubo K, Matsuzawa Y, Memoto Y, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Watanabe M
    • Journal Title

      Sci Rep

      Volume: 6 Pages: 36780-36780

    • DOI

      10.1038/srep36780

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H05286, KAKENHI-PROJECT-26460963, KAKENHI-PROJECT-15K15288
  • [Journal Article] PGE2 is a direct and robust mediator of anion/fluid secretion by human intestinal epithelial cells2016

    • Author(s)
      Fujii S, Okamoto R, Suzuki K, Kawamoto A, Ishibashi F, Nakata T, Murano T, Ito G, Shimizu H, Mizutani T, Oshima S, Tsuchiya K, Nakamura T, Araki A, Ohtsuka K, Watanabe M
    • Journal Title

      Sci Rep

      Volume: 6 Pages: 36795-36795

    • DOI

      10.1038/srep36795

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-15K15286, KAKENHI-PROJECT-16K09302
  • [Journal Article] Evaluation of Interferon Resistance in Newly Established Genotype 1b Hepatitis C Virus Cell Culture System.2016

    • Author(s)
      Taniguchi M, Tasaka-Fujita M, Nakagawa M, Watanabe T, Kawai-Kitahata F, Otani S, Goto F, Nagata H, Kaneko S, Nitta S, Murakawa M, Nishimura-Sakurai Y, Azuma S, Itsui Y, Mori K, Yagi S, Kakinuma S, Asahina Y, Watanabe M.
    • Journal Title

      J Clin Transl Hepatol.

      Volume: 4 Pages: 5-11

    • DOI

      10.14218/jcth.2015.00047

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K08988, KAKENHI-PROJECT-26460986, KAKENHI-PROJECT-25293169, KAKENHI-PROJECT-15K08989, KAKENHI-PROJECT-16H05285, KAKENHI-PROJECT-26460987, KAKENHI-PROJECT-15K15285, KAKENHI-PROJECT-15K19316
  • [Journal Article] Reduced Human ホア-defensin 6 in Noninflamed Jejunal Tissue of Patients with Crohn's Disease.2016

    • Author(s)
      Hayashi R , Tsuchiya K, Okamoto R,Watanabe M,et al
    • Journal Title

      Inflamm Bowel Dis.

      Volume: 22 Pages: 1119-1128

    • DOI

      10.1097/mib.0000000000000707

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K15286, KAKENHI-PROJECT-15K15287, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-25460945, KAKENHI-PROJECT-25461031, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-16K09302
  • [Journal Article] Epithelial Nuclear Factor-kappa B Activation in Inflammatory Bowel Diseases and Colitis-Associated Carcinogenesis2016

    • Author(s)
      Nagaishi T,Watabe T,Jose N, Tokai A, Fujii T, Matsuoka K, Nagahori M, Ohtsuka K
    • Journal Title

      Digestion.

      Volume: 93 Pages: 40-46

    • DOI

      10.1159/000441670

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26460963, KAKENHI-PROJECT-15K15288, KAKENHI-PROJECT-25461031, KAKENHI-PROJECT-26221307
  • [Journal Article] Co-culture with intestinal epithelial organoids allows efficient expansion and motility analysis of intraepithelial lymphocytes.2016

    • Author(s)
      Nozaki K, Mochizuki W, Matsumoto Y, Matsumoto T, Fukuda M, Mizutani T, Watanabe M, Nakamura T
    • Journal Title

      J Gastroenterol.

      Volume: 51 Pages: 206-213

    • DOI

      10.1007/s00535-016-1170-8

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-26112705, KAKENHI-PROJECT-25293170, KAKENHI-PROJECT-26221307
  • [Journal Article] Efficacy of additional radiofrequency ablation after transcatheter arterial chemoembolization for intermediate hepatocellular carcinoma.2016

    • Author(s)
      Azuma S, Asahina Y, Nishimura-Sakurai Y, Kakinuma S, Kaneko S, Nagata H, Goto F, Ootani S, Kawai-Kitahata F, Taniguchi M, Murakawa M, Watanabe T, Tasaka-Fujita M, Itsui Y, Nakagawa M, Watanabe M.
    • Journal Title

      Hepatol Res

      Volume: 46 Pages: 312-319

    • DOI

      10.1111/hepr.12566

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K08988, KAKENHI-PROJECT-26460986, KAKENHI-PROJECT-25293169, KAKENHI-PROJECT-15K08989, KAKENHI-PROJECT-16H05285, KAKENHI-PROJECT-16K09345, KAKENHI-PROJECT-15K15285
  • [Journal Article] Human induced pluripotent stem cell-derived hepatic cell lines as a new model for host interaction with hepatitis B virus2016

    • Author(s)
      Kaneko S, Kakinuma S, Asahina Y, Kamiya A, Miyoshi M, Tsunoda T, Nitta S, Asano Y, Nagata H, Otani S, Kitahata F, Murakawa M, Itsui Y, Nakagawa M, Azuma S, Nakauchi H, Iwamoto M, Watashi K, Wakita T, Sugiyama M, Mizokami M, Shimotohno K, Watanabe M.
    • Journal Title

      Sci. Rep

      Volume: 6 Pages: 29358-29358

    • DOI

      10.1038/srep29358

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05285, KAKENHI-PROJECT-26293178, KAKENHI-PROJECT-16K09345, KAKENHI-PROJECT-26460987, KAKENHI-PROJECT-15K15285, KAKENHI-PROJECT-15K19316, KAKENHI-PROJECT-15K08988, KAKENHI-PROJECT-15K08989, KAKENHI-PROJECT-26460565
  • [Journal Article] Magnetic resonance enterography for the evaluation of the deep small intestine in Crohn's disease.2016

    • Author(s)
      Ohtsuka K, Takenaka K, Kitazume Y, Fujii T, Matsuoka K, Kimura M, Nagaishi T, Watanabe M.
    • Journal Title

      Intest Res

      Volume: 14 Pages: 120-126

    • DOI

      10.5217/ir.2016.14.2.120

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05286, KAKENHI-PROJECT-26460963, KAKENHI-PROJECT-15K15288
  • [Journal Article] Novel CD200 homologues iSEC1 and iSEC2 are gastrointestinal secretory cell-specific ligands of inhibitory receptor CD200R.2016

    • Author(s)
      Kojima, T., Tsuchiya, K., Ikemizu, S., Yoshikawa, S., Yamanishi, Y., Watanabe, M., and Karasuyama, H.
    • Journal Title

      Sci Rep

      Volume: 6 Pages: 36457-36457

    • DOI

      10.1038/srep36457

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15H05786, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-15K20969
  • [Journal Article] Comprehensive analyses of mutations and hepatitis B virus integration in hepatocellular carcinoma with clinicopathological features2016

    • Author(s)
      Kawai-Kitahata F, Asahina Y, Tanaka S, Kakinuma S, Murakawa M, Sayuri Nitta S, Watanabe T, Otani S, Taniguchi M, Goto F, Nagata H, Kaneko S, Tasaka-Fujita M, Nishimura-Sakurai Y, Azuma S, Itsui Y, Nakagawa M, Tanabe M, Takano S, Fukasawa M, Sakamoto M, Maekawa S, Enomoto N, Watanabe M.
    • Journal Title

      J Gastroenterol.

      Volume: 51 Pages: 473-486

    • DOI

      10.1007/s00535-015-1126-4

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25253081, KAKENHI-PROJECT-26460986, KAKENHI-PROJECT-26670380, KAKENHI-PROJECT-25293169, KAKENHI-PROJECT-16H02670, KAKENHI-PROJECT-16H05285, KAKENHI-PROJECT-16K09345, KAKENHI-PROJECT-15K15285, KAKENHI-PROJECT-15K19316, KAKENHI-PROJECT-15K08988, KAKENHI-PROJECT-15K08989, KAKENHI-PROJECT-15K08995
  • [Journal Article] Atonal homolog 1 protein stabilized by tumor necrosis factor α induces high malignant potential in colon cancer cell line.2015

    • Author(s)
      Keita Fukushima, Kiichiro Tsuchiya,Okamoto Ryuichi, Mamoru Watanabe,et al
    • Journal Title

      Cancer Sci.

      Volume: 106 Pages: 1000-1007

    • DOI

      10.1111/cas.12703

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K15286, KAKENHI-PROJECT-15K15287, KAKENHI-PROJECT-15K15288, KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-25293170
  • [Journal Article] TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy.2015

    • Author(s)
      Matsuzawa Y, Oshima S, Takahara M, Maeyashiki C, Nemoto Y, Kobayashi M, Nibe Y, Nozaki K, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Averil Ma, Watanabe M
    • Journal Title

      Autophagy

      Volume: 11 Pages: 1052-1062

    • DOI

      10.1080/15548627.2015.1055439

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460963, KAKENHI-PROJECT-15K15286, KAKENHI-PROJECT-15K15288, KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-25460946, KAKENHI-PROJECT-25293170
  • [Journal Article] Correlation of the Endoscopic and Magnetic Resonance Scoring Systems in the Deep Small Intestine in Crohn's Disease.2015

    • Author(s)
      Takenaka K, Ohtsuka K, Kitazume Y, Nagahori M, Fujii T, Saito E, Fujioka T, Matsuoka K, Naganuma M, Watanabe M
    • Journal Title

      Inflamm Bowel Dis.

      Volume: 21 Pages: 1832-1838

    • DOI

      10.1097/mib.0000000000000449

    • NAID

      40020750618

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-25461031
  • [Journal Article] Tacrolimus for the Treatment of Ulcerative Colitis.2015

    • Author(s)
      Matsuoka K, Saito E, Fujii T, Takenaka K, Kimura M, Nagahori M, Ohtsuka K, Watanabe M.
    • Journal Title

      Intest Res

      Volume: 13 Pages: 219-226

    • DOI

      10.5217/ir.2015.13.3.219

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26460963, KAKENHI-PROJECT-25461031
  • [Journal Article] Correlation of the endoscopic and magnetic resonance scoring systems in the deep small intestine in Crohn’s disease.2015

    • Author(s)
      Takenaka K, Ohtsuka K, Kitazume Y, Nagahori M, Fujii T, Saito E, Fujioka T, Matsuoka K, Naganuma M, Watanabe M
    • Journal Title

      Inflamm Bowel Dis.

      Volume: 未

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460963
  • [Journal Article] RIPK3 regulates p62- LC3 complex formation via the caspase-8-dependent cleavage of p622015

    • Author(s)
      Y. Matsuzawa , S. Oshima, Y. Nibe, M.Kobayashi, C. Maeyashiki, Y. Nemoto, T. Nagaishi, R. Okamoto R, K. Tsuchiya, T. Nakamura, M. Watanabe.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 456(1) Pages: 298-304

    • DOI

      10.1016/j.bbrc.2014.11.075

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-24590935, KAKENHI-PROJECT-24590936, KAKENHI-PROJECT-24590937, KAKENHI-PUBLICLY-25114703, KAKENHI-PUBLICLY-25130704, KAKENHI-PROJECT-25293170, KAKENHI-PROJECT-25460946, KAKENHI-PROJECT-26460963, KAKENHI-PROJECT-26221307
  • [Journal Article] Safety and Efficacy of AJM300, an Oral Antagonist of α4 Integrin, in Induction Therapy for Patients with Active Ulcerative Colitis.2015

    • Author(s)
      Yoshimura N, Watanabe M, Motoya S, Tominaga K, Matsuoka K, Iwakiri R, Watanabe K, Hibi T, AJM300 Study Group
    • Journal Title

      Gastroenterology

      Volume: 149 Pages: 1775-1783

    • DOI

      10.1053/j.gastro.2015.08.044

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K15288, KAKENHI-PROJECT-26221307
  • [Journal Article] クローン病画像モダリティとしてのMRI2015

    • Author(s)
      藤井俊光、渡辺 守
    • Journal Title

      日本消化器病学会雑誌

      Volume: 112 Pages: 15-22

    • NAID

      130005084744

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26460963
  • [Journal Article] Impaired induction of interleukin 28B and expression of interferon λ 4 associated with nonresponse to interferon-based therapy in chronic hepatitis C.2015

    • Author(s)
      Murakawa M, Asahina Y, Nakagawa M, Sakamoto N, Nitta S, Kusano-Kitazume A, Watanabe T, Kawai-Kitahata F, Otani S, Taniguchi M, Goto F, Nishimura-Sakurai Y, Itsui Y, Azuma S, Kakinuma S, Watanabe M.
    • Journal Title

      J Gastroenterol Hepatol.

      Volume: in press

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24590959
  • [Journal Article] Impaired induction of interleukin 28B and expression of interferon λ 4 associated with nonresponse to interferon-based therapy in chronic hepatitis C.2015

    • Author(s)
      Murakawa M, Asahina Y, Nakagawa M, Sakamoto N, Nitta S, Kusano-Kitazume A, Watanabe T, Kawai-Kitahata F, Otani S, Taniguchi M, Goto F, Nishimura-Sakurai Y, Itsui Y, Azuma S, Kakinuma S, Watanabe M
    • Journal Title

      Journal of Gastroenterology and Hepatology

      Volume: 印刷中 Pages: 1075-84

    • DOI

      10.1111/jgh.12902

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24390185, KAKENHI-PROJECT-24590957, KAKENHI-PROJECT-24590958, KAKENHI-PROJECT-24590960, KAKENHI-PROJECT-25670366, KAKENHI-PROJECT-26460986, KAKENHI-PROJECT-26460987, KAKENHI-PROJECT-26460988, KAKENHI-PROJECT-26670375, KAKENHI-PROJECT-15K08988, KAKENHI-PROJECT-15K19316, KAKENHI-PROJECT-15K08989
  • [Journal Article] Associations of HLA class I alleles in Japanese patients with Crohn's disease.2015

    • Author(s)
      102)Oryoji D, Hisamatsu T, Tsuchiya K, Umeno J, Ueda S, Yamamoto K, Matsumoto T, Watanabe M, Hibi T, Sasazuki T.
    • Journal Title

      Genes Immun.

      Volume: 16 Pages: 54-56

    • DOI

      10.1038/gene.2014.61

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PLANNED-22133009, KAKENHI-PROJECT-24590935, KAKENHI-PUBLICLY-25114703, KAKENHI-PUBLICLY-25130704
  • [Journal Article] Advancing magnetic resonance imaging in Crohn's disease2014

    • Author(s)
      Fujii T, Naganuma M, Kitazume Y, Saito E, Nagahori M, Ohtsuka K, Watanabe M.
    • Journal Title

      Digestion.

      Volume: 89 Pages: 24-30

    • DOI

      10.1159/000356210

    • NAID

      130005084744

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590934, KAKENHI-PROJECT-24590937, KAKENHI-PROJECT-25461031, KAKENHI-PROJECT-26460963
  • [Journal Article] Matrix Metalloproteinase-14 regulates the maturation of fetal hepatic stem/progenitor cells in mice2014

    • Author(s)
      Otani S, Kakinuma S, Kamiya A, Goto F, Kaneko S, Azuma S, Asahina Y, Watanabe M
    • Journal Title

      Hepatology

      Volume: 60

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590959
  • [Journal Article] Matrix Metalloproteinase-14 regulates the maturation of fetal hepatic stem/progenitor cells in mice2014

    • Author(s)
      Otani S, Kakinuma S, Kamiya A, Goto F, Kaneko S, Azuma S, Asahina Y, Watanabe M
    • Journal Title

      Heoatology

      Volume: 60

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590957
  • [Journal Article] 内科疾患最新の治療 明日への指針 第2章消化器 Crohn病2014

    • Author(s)
      藤井俊光, 渡辺守
    • Journal Title

      内科

      Volume: 113 Pages: 1062-1065

    • Data Source
      KAKENHI-PROJECT-26460963
  • [Journal Article] Myosin light chain kinase expression induced via tumor necrosis factor receptor 2 signaling in the epithelial cells regulates the development of colitis-associated carcinogenesis2014

    • Author(s)
      Suzuki M, Nagaishi T, Watanabe M(他12名)
    • Journal Title

      PLoS One

      Volume: 9(2)

    • Data Source
      KAKENHI-PROJECT-23590934
  • [Journal Article] Comparison of magnetic resonance and balloon enteroscopic examination of the small intestine in patients with Crohn’s disease.2014

    • Author(s)
      Takenaka K, Ohtsuka K,Watanabe M et al
    • Journal Title

      Gastroenterology.

      Volume: [Epub ahead of print] Pages: 334-342

    • DOI

      10.1053/j.gastro.2014.04.008

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-22229005, KAKENHI-PROJECT-23590934, KAKENHI-PROJECT-24590936, KAKENHI-PROJECT-24590937, KAKENHI-PROJECT-25460945, KAKENHI-PROJECT-25461031, KAKENHI-PROJECT-25670367, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-26460963
  • [Journal Article] Distinct expression patterns of Notch ligands, Dll1 and Dll4, in normal and inflamed mice intestine.2014

    • Author(s)
      Shimizu H, Okamoto R, Ito G, Nakata T, Suzuki K, Murano T, Mizutani T, Tsuchiya K, Nakamura T, Hozumi K, Watanabe M.
    • Journal Title

      2014

      Volume: 2

    • DOI

      10.7717/peerj.370

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-24590935, KAKENHI-PUBLICLY-25114703, KAKENHI-PUBLICLY-25130704, KAKENHI-PROJECT-25293170, KAKENHI-PROJECT-25860524
  • [Journal Article] Advancing MR imaging in Crohn's disease2014

    • Author(s)
      Fujii T, Watanabe M(他5名)
    • Journal Title

      Digestion

      Volume: 89(1) Pages: 24-30

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590934
  • [Journal Article] Fluorescent labelling of intestinal epithelial cells reveals independent long-lived intestinal stem cells in a crypt.2014

    • Author(s)
      N. Horita, K. Tsuchiya, R. Hayashi, K. Fukushima, S. Hibiya, M. Fukuda, Y. Kano, T. Mizutani, Y. Nemoto, S. Yui, R. Okamoto, T. Nakamura, M. Watanabe
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 454 Pages: 493-499

    • DOI

      10.1016/j.bbrc.2014.10.091

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-24590935, KAKENHI-PUBLICLY-25114703, KAKENHI-PUBLICLY-25130704, KAKENHI-PROJECT-25293170, KAKENHI-PROJECT-25670367, KAKENHI-PROJECT-25860524, KAKENHI-PROJECT-26221307
  • [Journal Article] Efficacy of salvage therapy and its effect on operative outcomes in patients with ulcerative colitis.2014

    • Author(s)
      Saito E, Nagahori M, Fujii T, Otsuka K, Watanabe M
    • Journal Title

      Digestion.

      Volume: 89 Pages: 55-60

    • DOI

      10.1159/000356221

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590934, KAKENHI-PROJECT-24590937, KAKENHI-PROJECT-25461031, KAKENHI-PROJECT-26460963
  • [Journal Article] Pre-illness isoflavone consumption and disease risk of ulcerative colitis: a multicenter case-control study in Japan.2014

    • Author(s)
      Ohfuji S, Fukushima W, Watanabe K, Sasaki S, Yamagami H, Nagahori M, Watanabe M, Hirota Y; Japanese Case-Control Study Group for Ulcerative Colitis
    • Journal Title

      PLoS ONE

      Volume: 9

    • DOI

      10.1371/journal.pone.0110270

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24590937
  • [Journal Article] The advances of balloon endoscope2014

    • Author(s)
      Araki A, Tsuchiya K, Watanabe M.
    • Journal Title

      Clinical Journal of Gastroenterology

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25460945
  • [Journal Article] Hes1 promotes the IL-22-mediated antimicrobial response by enhancing STAT3-dependent transcription in human intestinal epithelial cells.2014

    • Author(s)
      Murano T, Okamoto R, Ito G, Nakata T, Hibiya S, Shimizu H, Fujii S, Kano Y, Mizutani T, Yui S, Akiyama-Morio J, Nemoto Y, Tsuchiya K, Nakamura T, Watanabe M
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 443 Pages: 840-6

    • DOI

      10.1016/j.bbrc.2013.12.061

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24590935, KAKENHI-PUBLICLY-25114703, KAKENHI-PUBLICLY-25130704, KAKENHI-PROJECT-25293170, KAKENHI-PROJECT-25670367, KAKENHI-PROJECT-25860524, KAKENHI-PROJECT-26221307
  • [Journal Article] Genetic variation near interleukin 28B and the risk of hepatocellular carcinoma in patients with chronic hepatitis C.2014

    • Author(s)
      Asahina Y, Tsuchiya K, Nishimura T, Muraoka M, Suzuki Y, Tamaki N, Yasui Y, Hosokawa T, Ueda K, Nakanishi H, Itakura J, Takahashi Y, Kurosaki M, Enomoto N, Nakagawa M, Kakinuma S, Watanabe M, Izumi N.
    • Journal Title

      J Gastroenterol

      Volume: in press

    • DOI

      10.1007/s00535-013-0858-2

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590957, KAKENHI-PROJECT-24590959
  • [Journal Article] Primary hepatic neuroendocrine carcinoma with a cholangiocellular carcinoma component in one nodule.2014

    • Author(s)
      Kano Y, Kakinuma S, Goto F, Azuma S, Nishimura-Sakurai Y, Itsui Y, Nakagawa M, Kudo A, Tanabe M, Kirimura S, Amano T, Ito T, Akashi T, Asahina Y, Watanabe M.
    • Journal Title

      Clin J Gastroenterol

      Volume: 7 Pages: 449-454

    • DOI

      10.1007/s12328-014-0521-3

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24590957, KAKENHI-PROJECT-24590959
  • [Journal Article] Myosin light chain kinase expression induced via tumor necrosis factor receptor 2 signaling in the epithelial cells regulates the development of colitis-associated carcinogenesis2014

    • Author(s)
      Suzuki M, Nagaishi T, Yamazaki M, Onizawa M, Watabe T, Sakamaki Y, Ichinose S, Totsuka M, Oshima S, Okamoto R, Shimonaka M, Yagita H, Nakamura T, Watanabe M.
    • Journal Title

      PLoS One.

      Volume: 9

    • DOI

      10.1371/journal.pone.0088369

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-24590936, KAKENHI-PROJECT-24590937, KAKENHI-PROJECT-25293170, KAKENHI-PROJECT-25670367, KAKENHI-PROJECT-25670708, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-26460963
  • [Journal Article] The clinical relevance of tacrolimus trough levels in outpatients with active ulcerative colitis2014

    • Author(s)
      Naganuma M, Suzuki Y, Matsuoka K, Kunisaki R, Yoshimura N, Nagahori M, Watanabe M
    • Journal Title

      Nippon Shokakibyo Gakkai Zasshi

      Volume: 111 Issue: 2 Pages: 276-287

    • DOI

      10.11405/nisshoshi.111.276

    • NAID

      130003391998

    • ISSN
      0446-6586, 1349-7693
    • Language
      Japanese
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590937
  • [Journal Article] Small intestinal stem cell identity is maintained with functional Paneth cells in heterotopically grafted epithelium onto the colon.2014

    • Author(s)
      Fukuda M, Mizutani T, Mochizuki W, Matsumoto T, Nozaki K, Sakamaki Y, Ichinose S, Okada Y, Tanaka T, Watanabe M, Nakamura T
    • Journal Title

      Genes Dev.

      Volume: 28(16) Pages: 1752-1757

    • DOI

      10.1101/gad.245233.114

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24390186, KAKENHI-PROJECT-24590936, KAKENHI-PROJECT-25670106, KAKENHI-PROJECT-25670367, KAKENHI-PROJECT-25860524, KAKENHI-PUBLICLY-26112705, KAKENHI-PROJECT-26221307
  • [Journal Article] シグナル伝達を理解するために必要な知識(第43回)(No.85) 肝細胞癌のシグナル伝達と治療標的2014

    • Author(s)
      井津井康浩、朝比奈靖浩、渡辺守
    • Journal Title

      分子消化器病

      Volume: 11巻3号 Pages: 277-282

    • Data Source
      KAKENHI-PROJECT-26460987
  • [Journal Article] Polymorphism near the Interleukin-28B gene and anti-hepatitis C viral response.2013

    • Author(s)
      Asahina Y, Nakagawa M, Kakinuma S, Watanabe M.
    • Journal Title

      J Clin Transl Hepatol

      Volume: 1 Pages: 39-44

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590959
  • [Journal Article] 潰瘍性大腸炎に対する生物学的製剤による治療2013

    • Author(s)
      長堀 正和, 藤井 俊光, 齊藤 詠子, 大塚 和朗, 渡辺 守
    • Journal Title

      日本消化器病学会雑誌

      Volume: 110 Pages: 1909-1915

    • NAID

      130003383310

    • Data Source
      KAKENHI-PROJECT-23590934
  • [Journal Article] Incidence and characteristics of the 2009 influenza (H1N1) infections in inflammatory bowel disease patients2013

    • Author(s)
      Naganuma M, Fujii T, Kunisaki R, Yoshimura N, Takazoe M, Takeuchi Y, Saito E, Nagahori M, Asakura K, Takebayashi T, Watanabe M
    • Journal Title

      J Crohns Colitis

      Volume: 7 Pages: 308-313

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590696
  • [Journal Article] 【小腸疾患の臨床-最近の進歩】クローン病に対するMREC(MR enterocolonography)の有用性2013

    • Author(s)
      藤井俊光,渡辺守他
    • Journal Title

      臨床消化器内科

      Volume: (0911-601X), 28巻7号 Pages: 1069-1075

    • Data Source
      KAKENHI-PROJECT-23590934
  • [Journal Article] IL-7 promotes long-term in vitro survival of unique long-lived memory subset generated from mucosal effector memory CD4+ T cells in chronic colitis mice2013

    • Author(s)
      Takahara M, Nemoto Y, Oshima S, Matsuzawa Y, Kanai T, Okamoto R, Tsuchiya K, Nakamura T, Yamamoto K, Watanabe M.
    • Journal Title

      Immunol Lett

      Volume: 156 Pages: 82-93

    • DOI

      10.1016/j.imlet.2013.09.001

    • NAID

      120005468269

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-24590935, KAKENHI-PROJECT-24590936, KAKENHI-PUBLICLY-25114703, KAKENHI-PUBLICLY-25130704, KAKENHI-PROJECT-25293170
  • [Journal Article] 生物学的製剤によるIBD治療戦略の進歩 どう変わっていくか2013

    • Author(s)
      藤井 俊光, 渡辺 守
    • Journal Title

      消化器の臨床

      Volume: 16 Pages: 454-459

    • Data Source
      KAKENHI-PROJECT-23590934
  • [Journal Article] Establishment of Fetal Enteric Progenitors as a Source for Transplantation2013

    • Author(s)
      Fordham RP, Watanabe M(他7名)
    • Journal Title

      Cell Stem Cell

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590934
  • [Journal Article] 【潰瘍性大腸炎診療のトピックス】潰瘍性大腸炎に対する生物学的製剤による治療2013

    • Author(s)
      長堀正和,藤井俊光,渡辺守
    • Journal Title

      日本消化器病学会雑誌

      Volume: (0446-6586), 110巻11号 Pages: 1909-1915

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590934
  • [Journal Article] Poor recall of prior exposure to varicella zoster, rubella, measles, or mumps in patients with IBD2013

    • Author(s)
      Naganuma M, Fujii T, Watanabe M(他3名)
    • Journal Title

      Inflamm Bowel Dis

      Volume: 19 Pages: 418-22

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590934
  • [Journal Article] Association of ITPA gene variant and serum ribavirin concentration with blood cells decline in pegylated interferon-alfa plus ribavirin therapy for chronic hepatitis C2013

    • Author(s)
      Nakagawa M, Azuma S, Kakinuma S, Watanabe M, et al.
    • Journal Title

      Hepatol Int

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590959
  • [Journal Article] Polymorphism near the Interleukin-28B gene and anti-hepatitis C viral response.2013

    • Author(s)
      Asahina Y, Nakagawa M, Kakinuma S, Watanabe M.
    • Journal Title

      J Clin Transl Hepatol

      Volume: 1 Pages: 39-44

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590957
  • [Journal Article] Lineage-specific expression of bestrophin-2 and bestrophin-4 in human intestinal epithelial cells2013

    • Author(s)
      Ito G, Okamoto R, Nakamura T, Watanabe M et al
    • Journal Title

      PLoS One.

      Volume: 8

    • DOI

      10.1371/journal.pone.0079693

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229005, KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-24590935, KAKENHI-PROJECT-24590936, KAKENHI-PUBLICLY-25114703, KAKENHI-PUBLICLY-25130704, KAKENHI-PROJECT-25293170, KAKENHI-PROJECT-25460945, KAKENHI-PROJECT-25461031, KAKENHI-PROJECT-25670367, KAKENHI-PROJECT-25860524
  • [Journal Article] Incidence and characteristics of the 2009 influenza (H1N1) infections in inflammatory bowel disease patients2013

    • Author(s)
      Naganuma M, Fujii T, Watanabe M(他9名)
    • Journal Title

      J Crohns Colitis

      Volume: 7 Pages: 308-313

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590934
  • [Journal Article] Randomised clinical trial: evaluation of the efficacy of mesalazine (mesalamine) suppositories in patients with ulcerative colitis and active rectal inflammation -- a placebo-controlled study.2013

    • Author(s)
      Watanabe M, Nishino H, Sameshima Y, Ota A, Nakamura S, Hibi T
    • Journal Title

      Aliment Pharmacol Ther

      Volume: 38 Pages: 264-273

    • DOI

      10.1111/apt.12362

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590934, KAKENHI-PROJECT-24590936
  • [Journal Article] Genetic variation near interleukin 28B and the risk of hepatocellular carcinoma in patients with chronic hepatitis C.2013

    • Author(s)
      Asahina Y, Tsuchiya K, Nishimura T, Muraoka M, Suzuki Y, Tamaki N, Yasui Y, Hosokawa T, Ueda K, Nakanishi H, Itakura J, Takahashi Y, Kurosaki M, Enomoto N, Nakagawa M, Kakinuma S, Watanabe M,Izumi N
    • Journal Title

      Journal of Gastroenterology

      Volume: (in press) Pages: 1253-1262

    • DOI

      10.1002/hep.26442

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-23390195, KAKENHI-PROJECT-24590957, KAKENHI-PROJECT-24590958, KAKENHI-PROJECT-24590960, KAKENHI-PROJECT-25293169, KAKENHI-PROJECT-25670366
  • [Journal Article] Poor recall of prior exposure to varicella zoster, rubella, measles, or mumps in patients with IBD.2013

    • Author(s)
      Naganuma M, Nagahori M, Fujii T, Morio J, Saito E, Watanabe M
    • Journal Title

      Inflamm Bowel Dis.

      Volume: 19 Pages: 418-22

    • DOI

      10.1002/ibd.23027

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590696, KAKENHI-PROJECT-23590934, KAKENHI-PROJECT-24590937
  • [Journal Article] Th1/Th7-Mediated Interstitial Pneumonia in Chronic Colitis Mice Independent of Intestinal Microbiota2013

    • Author(s)
      Nemoto Y, Watanabe M(他6名)
    • Journal Title

      J Immunol

      Volume: 190 Pages: 6616-6625

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590934
  • [Journal Article] Histological diagnosis of follicular lymphoma by biopsy of small intestinal normal mucosa.2013

    • Author(s)
      Okada E, Araki A, Suzuki S, Watanabe H, Ikeda T, Watanabe T, Kurata M, EishiY, Watanabe M
    • Journal Title

      Dig Endosc.

      Volume: in press Pages: 22-22

    • DOI

      10.1111/j.1443-1661.2012.01386.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590694, KAKENHI-PROJECT-22590695, KAKENHI-PROJECT-23790776, KAKENHI-PROJECT-25460945
  • [Journal Article] Th1/Th17-mediated interstitial pneumonia in chronic colitis mice independent of intestinal microbiota2013

    • Author(s)
      Nemoto Y, Watanabe M et al
    • Journal Title

      J Immunol

      Volume: 190 Pages: 6616-25

    • DOI

      10.4049/jimmunol.1202930

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229005, KAKENHI-PROJECT-23590934, KAKENHI-PROJECT-24590935, KAKENHI-PROJECT-24590936, KAKENHI-PROJECT-24659375, KAKENHI-PUBLICLY-25114703, KAKENHI-PUBLICLY-25130704, KAKENHI-PROJECT-25293170, KAKENHI-PROJECT-25670367
  • [Journal Article] The early retinal progenitor-expressed gene Sox11 regulates the timing of the differentiation of retinal cells.2013

    • Author(s)
      Kakinuma S, Kiyohashi K, Kamiya A, Sakamoto N, Nitta S, Yamanaka H, YoshinoK, Fujiki J, Murakawa M, Kusano-Kitazume A, Shimizu H, Okamoto R, Azuma S, Nakagawa M, Asahina Y, Tanimizu N, Kikuchi A, Nakauchi H, and *WatanabeM
    • Journal Title

      Development

      Volume: (in press) Pages: 2502-13

    • DOI

      10.1002/hep.26293

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-21590831, KAKENHI-ORGANIZER-23112001, KAKENHI-PLANNED-23112004, KAKENHI-PROJECT-23689040, KAKENHI-PROJECT-23790777, KAKENHI-PUBLICLY-24112505, KAKENHI-PUBLICLY-24112519, KAKENHI-PROJECT-24390304, KAKENHI-PROJECT-24590957, KAKENHI-PROJECT-24590958, KAKENHI-PROJECT-24590959, KAKENHI-PROJECT-24590960, KAKENHI-PROJECT-24659359, KAKENHI-PROJECT-25250018, KAKENHI-PROJECT-25293169, KAKENHI-PROJECT-25293289, KAKENHI-PROJECT-25460271, KAKENHI-PROJECT-25670366, KAKENHI-PROJECT-25860522, KAKENHI-PLANNED-23102003, KAKENHI-PLANNED-23106004
  • [Journal Article] 多血性肝細胞癌の検出能に関するGd-EOB-DTPA造影MRIとCTAP/CTHAとの比較検討2013

    • Author(s)
      東 正新、柿沼 晴、渡辺 守、他
    • Journal Title

      医学と薬学

      Volume: 69 Pages: 64-66

    • Data Source
      KAKENHI-PROJECT-24590959
  • [Journal Article] 【抗体医薬による消化器治療のパラダイムシフト】【炎症性腸疾患(IBD)に対する生物学的製剤治療】生物学的製剤によるIBD治療戦略の進歩どう変わっていくか2013

    • Author(s)
      藤井俊光,渡辺守
    • Journal Title

      消化器の臨床

      Volume: (1344-3070), 16巻5号 Pages: 454-459

    • Data Source
      KAKENHI-PROJECT-23590934
  • [Journal Article] クローン病に対するMREC(MR enterocolonography)の有用性2013

    • Author(s)
      藤井 俊光, 北詰 良雄, 長沼 誠, 齊藤 詠子, 長堀 正和, 大塚 和朗, 渡辺 守
    • Journal Title

      臨床消化器内科

      Volume: 28 Pages: 1069-1075

    • Data Source
      KAKENHI-PROJECT-23590934
  • [Journal Article] Comparison of QD and TID oral mesalazine for maintenance of remission in quiescent ulcerative colitis: a double-blind, double-dummy, randomized multicenter study.2013

    • Author(s)
      Watanabe M, Hanai H, Nishino H, Yokoyama T, Terada T, Suzuki Y
    • Journal Title

      Inflamm Bowel Dis

      Volume: 19 Pages: 1681-1690

    • DOI

      10.1097/mib.0b013e318286fa3d

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590934, KAKENHI-PROJECT-24590936
  • [Journal Article] Hepatitis C virus NS4B protein targets STING and abrogates RIG-I-mediated type I interferon-dependent innate immunity.2013

    • Author(s)
      Nitta S, Sakamoto N, Nakagawa M, Kakinuma S, Mishima K, Kusano-kitazume A, Kiyohashi K, Murakawa M, Nishimura-Sakurai Y, Azuma S, Tasaka-Fujita M, asahina Y, Yoneyama M, Fujita T, Watanabe M
    • Journal Title

      Hepatology

      Volume: 57 Pages: 46-58

    • DOI

      10.1002/hep.26017

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20112009, KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-23390108, KAKENHI-PROJECT-23790778, KAKENHI-PROJECT-24390185, KAKENHI-PROJECT-24590957, KAKENHI-PROJECT-24590958, KAKENHI-PROJECT-24590959, KAKENHI-PROJECT-24590960, KAKENHI-PROJECT-24659359, KAKENHI-PROJECT-24890058, KAKENHI-PROJECT-25293169, KAKENHI-PROJECT-25670366, KAKENHI-PROJECT-25860522
  • [Journal Article] Bone marrow-mesenchymal stem cells are a major source of interleukin-7 and sustain colitis by forming the niche for colitogenic CD4+ memory T cells2013

    • Author(s)
      Nemoto Y, Watanabe M(他6名)
    • Journal Title

      Gut

      Volume: 62 Pages: 1142-1152

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590934
  • [Journal Article] The acquisition of malignant potential in colon cancer is regulated by the stabilization of Atonal homolog 1 protein2013

    • Author(s)
      Kano Y
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 432 Pages: 175-181

    • DOI

      10.1016/j.bbrc.2013.01.034

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-ORGANIZER-22130001, KAKENHI-PLANNED-22130009, KAKENHI-PROJECT-22229005, KAKENHI-PROJECT-23390062, KAKENHI-PROJECT-23659394, KAKENHI-PROJECT-23790357, KAKENHI-PROJECT-23790777, KAKENHI-PROJECT-24590935, KAKENHI-PLANNED-23102003, KAKENHI-PUBLICLY-23130506
  • [Journal Article] Chronic Inflammatory Demyelinating Polyradiculoneuropathy in a Patient with Crohn's Disease2013

    • Author(s)
      Ohyagi , Akiyama J, Watanabe M et al
    • Journal Title

      Internal Medicine

      Volume: 52 Issue: 1 Pages: 125-128

    • DOI

      10.2169/internalmedicine.52.8452

    • NAID

      130003365560

    • ISSN
      0918-2918, 1349-7235
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23790776, KAKENHI-PROJECT-24590937
  • [Journal Article] Endocytoscopy provides an in vivo virtual histopathological diagnosis of Whipple's disease.2013

    • Author(s)
      Watanabe D, Kudo SE, Hayashi S, Mori Y, Kodama K, Wakamura K, Miyachi H, Yamamura F, Ohtsuka K, Mikogami T, Kimura S, Fukuchi K, Ikehara N.
    • Journal Title

      Endoscopy

      Volume: 45 Pages: 143-144

    • DOI

      10.1055/s-0032-1326276

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25461031
  • [Journal Article] Association of ITPA gene variation and serum ribavirinconcentration with a decline in blood cell concentrations during pegylated interferon-alpha plus ribavirin therapy for chronic hepatitis C2013

    • Author(s)
      Nakagawa M, Sakamoto N, Watanabe T, Nishimura-Sakurai Y, Onozuka I, Azuma S, Kakinuma S, Nitta S, Kiyohashi K,Kusano-Kitazume A, Murakawa M, Yoshino K, Itsui Y, Tanaka Y, Mizokami M,Watanabe M, Ochanomizu Liver Conference Study Group
    • Journal Title

      Hepatol Int.

      Volume: 7(1) Pages: 153-161

    • DOI

      10.1007/s12072-012-9363-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23790778, KAKENHI-PROJECT-24590957, KAKENHI-PROJECT-24590958
  • [Journal Article] Endoscopic ultrasound with double-balloon endoscopy for the diagnosis of inverted Meckel's diverticulum : a case report2013

    • Author(s)
      Araki A, Fujii T, Watanabe M(他6名)
    • Journal Title

      J Med Case Rep

      Volume: 6 Pages: 328-328

    • Data Source
      KAKENHI-PROJECT-23590934
  • [Journal Article] Transplantation of expanded fetal intestinal progenitors contributes to colon regeneration after injury2013

    • Author(s)
      Fordham RP, Yui S, Nakamura T, Watanabe M et. al
    • Journal Title

      Cell Stem Cell

      Volume: 13 Pages: 734-744

    • DOI

      10.1016/j.stem.2013.09.015

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229005, KAKENHI-PROJECT-23590934, KAKENHI-PUBLICLY-24112508, KAKENHI-PROJECT-24390186, KAKENHI-PROJECT-24590936, KAKENHI-PROJECT-25670106, KAKENHI-PROJECT-25670367
  • [Journal Article] Incidence and characteristics of the 2009 influenza (H1N1) infections in inflammatory bowel disease patients.2013

    • Author(s)
      Naganuma M, Fujii T, Watanabe M. et al
    • Journal Title

      J Crohns Colitis.

      Volume: 7 Pages: 308-13

    • DOI

      10.1016/j.crohns.2012.06.019

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590934, KAKENHI-PROJECT-24590937
  • [Journal Article] The acquisition of malignant potential in colon cancer is regulated by the stabilization of Atonal homolog 1 protein2013

    • Author(s)
      Kano Y, Watanabe M(他12名)
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 432 Pages: 175-181

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590934
  • [Journal Article] Bone marrow-mesenchymal stem cells are a major source of interleukin-7 and sustain colitis by forming the niche for colitogenic CD4 memory T cells2013

    • Author(s)
      Nemoto Y, Nakamura T, Watanabe M et al
    • Journal Title

      Gut

      Volume: 62 Pages: 1142-1152

    • DOI

      10.1136/gutjnl-2012-302029

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229005, KAKENHI-PROJECT-23590934, KAKENHI-PROJECT-23659394, KAKENHI-PROJECT-23790777, KAKENHI-PROJECT-24590933, KAKENHI-PROJECT-24590935, KAKENHI-PROJECT-24590936, KAKENHI-PROJECT-24659375, KAKENHI-PROJECT-25293170, KAKENHI-PROJECT-25670367, KAKENHI-PLANNED-23102003, KAKENHI-PUBLICLY-23130506
  • [Journal Article] Lineage-specific expression of Bestrophin-2 and Bestrophin-4 in human intestinal epithelial cells2013

    • Author(s)
      Ito G, Watanabe M(他15名)
    • Journal Title

      PloS One

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590934
  • [Journal Article] Biologics treatment for ulcerative colitis2013

    • Author(s)
      Nagahori M, Fujii T, Saito E, Ohtsuka K, Watanabe M
    • Journal Title

      Nippon Shokakibyo Gakkai Zasshi

      Volume: 110 Issue: 11 Pages: 1909-1915

    • DOI

      10.11405/nisshoshi.110.1909

    • NAID

      130003383310

    • ISSN
      0446-6586, 1349-7693
    • Language
      Japanese
    • Data Source
      KAKENHI-PROJECT-24590937
  • [Journal Article] Identification of novel N-(morpholine-4-carbonyloxy) amidine compounds as potent inhibitors against hepatitis C virus replication.2012

    • Author(s)
      Kusano-Kitazume A, Sakamoto N, Okuno Y, Sekine-Osajima Y, Nakagawa M, Kakinuma S, Kiyohashi K, Nitta S, Murakawa M, Azuma S, Nishimura-Sakurai Y, Hagiwara M, Watanabe M.
    • Journal Title

      Antimicrob Agents Chemother.

      Volume: 56(3) Issue: 3 Pages: 1315-1323

    • DOI

      10.1128/aac.05764-11

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-21590832, KAKENHI-PROJECT-23790778, KAKENHI-PROJECT-24390185, KAKENHI-PROJECT-24590957, KAKENHI-PROJECT-24590959, KAKENHI-PROJECT-24659359, KAKENHI-PROJECT-21249013
  • [Journal Article] T-helper 17 and interleukin-17-producing lymphoid tissue inducer-like cells make different contributions to colitis in mice2012

    • Author(s)
      Ono Y, Watanabe M(他12名)
    • Journal Title

      Gastroenterology

      Volume: 143 Pages: 1288-1297

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590934
  • [Journal Article] Real-time analysis of P-glycoprotein-mediated drug transport across primary intestinal epithelium three-dimensionally cultured in vitro2012

    • Author(s)
      Mizutani T, Nakamura T, Morikawa R, Fukuda M, Mochizuki W, Yamauchi Y, Nozaki K, Yui S, Nemoto Y, Nagaishi T, Okamoto R, Tsuchiya K, and Watanabe M
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 419(2) Pages: 238-243

    • Data Source
      KAKENHI-PROJECT-21590803
  • [Journal Article] The development of colitogenic CD4+ T cells is regulated by IL-7 in collaboration with natural killer cell function in a murine model of colitis2012

    • Author(s)
      Nagaishi T, Watanabe M(他11名)
    • Journal Title

      J Immunol

      Volume: 188 Pages: 2524-2536

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590934
  • [Journal Article] Modified single-operator method for double-balloonendoscopy2012

    • Author(s)
      Araki A, Suzuki S, Tsuchiya K, OshimaS, Okada E, Watanabe M
    • Journal Title

      Dig Endosc.

      Volume: 24(6) Pages: 470-4

    • DOI

      10.1111/j.1443-1661.2012.01321.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590694, KAKENHI-PROJECT-22590695, KAKENHI-PROJECT-24590935, KAKENHI-PUBLICLY-23130506
  • [Journal Article] Endoscopic ultrasound with double-balloon endoscopy for the diagnosis of inverted Meckel's diverticulum: a case report2012

    • Author(s)
      Araki A, Tsuchiya K, Oshima S, Okada E,Suzuki S, Akiyama JM, Fujii T, OkamotoR, Watanabe M
    • Journal Title

      J Med Case Rep.

      Volume: 6(1) Pages: 328-328

    • DOI

      10.1186/1752-1947-6-328

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590694, KAKENHI-PROJECT-22590695, KAKENHI-PROJECT-23590934, KAKENHI-PROJECT-23790776, KAKENHI-PROJECT-23790777, KAKENHI-PROJECT-24590935, KAKENHI-PLANNED-23102003, KAKENHI-PUBLICLY-23130506
  • [Journal Article] NK細胞はIL-7と協調し腸炎惹起性T細胞の分化増殖を抑制する.2012

    • Author(s)
      永石宇司, 渡辺守、 他.
    • Journal Title

      日本臨床免疫学会誌

      Volume: 36

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590696
  • [Journal Article] Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+stem cell2012

    • Author(s)
      Yui S, Nakamura T, Nagaishi T, Okamoto R, Watanabe M, et al
    • Journal Title

      Nat Med

      Volume: 18 Pages: 618-623

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590806
  • [Journal Article] IBDモデルにおける病原性T細胞の分化増殖はIL-7とNK細胞によって制御される2012

    • Author(s)
      永石宇司、渡辺守、他
    • Journal Title

      消化器と免疫

      Volume: 49 Pages: 35-38

    • Data Source
      KAKENHI-PROJECT-22590696
  • [Journal Article] 慢性大腸炎モデルにおける腸炎惹起性T細胞の増殖はIL-7とNK細胞により制御される2012

    • Author(s)
      永石宇司、渡辺 守、他
    • Journal Title

      消化器と免疫

      Volume: in press

    • Data Source
      KAKENHI-PROJECT-22590696
  • [Journal Article] The development of colitogenic CD4+ T cells is regulated by IL-7 in collaboration with NK cell function in a murine model of colitis.2012

    • Author(s)
      Yamaji O, Totsuka T
    • Journal Title

      J. Immunol

      Volume: 188 Pages: 2524-2536

    • DOI

      10.4049/jimmunol.1100371

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590804, KAKENHI-PROJECT-21590805, KAKENHI-PROJECT-21590806, KAKENHI-PUBLICLY-22117508, KAKENHI-PROJECT-22229005, KAKENHI-PROJECT-22590694, KAKENHI-PROJECT-22590695, KAKENHI-PROJECT-22590696, KAKENHI-PUBLICLY-23130506, KAKENHI-PROJECT-23390112, KAKENHI-PROJECT-23590934, KAKENHI-PROJECT-23659223, KAKENHI-PROJECT-23659394, KAKENHI-PROJECT-23790777, KAKENHI-PROJECT-24590936, KAKENHI-PROJECT-24590937, KAKENHI-PLANNED-23102003
  • [Journal Article] Ochanomizu Liver Conference Study Group : Association of ITPA gene variant and serum ribavirin concentration with blood cells decline in pegylated interferon-alfa plus ribavirin therapy for chronic hepatitis C2012

    • Author(s)
      Nakagawa M, Sakamoto N, Watanabe T, Nishimura-Sakurai Y, Onozuka I, Azuma S, Kakinuma S, Nitta S, Kiyohashi K, Kusano-Kitazume A, Murakawa M, Yoshino K, Itsui Y, Tanaka Y, Mizokami M, Watanabe M
    • Journal Title

      Hepatol Int

      Volume: (in press)

    • Data Source
      KAKENHI-PROJECT-21590833
  • [Journal Article] Histologically confirmed IgG4-related small intestinal lesions diagnosed via double balloon enteroscopy2012

    • Author(s)
      Fujita K, Naganuma M, Saito E, Suzuki S, Araki A, Negi M, Kawachi H, Watanabe M
    • Journal Title

      Dig Dis Sci

      Volume: 57(12) Pages: 3303-6

    • DOI

      10.1007/s10620-012-2267-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590694
  • [Journal Article] 粘膜治癒・長期予後の面からみた難治性炎症性腸疾患の治療戦略2012

    • Author(s)
      長沼誠, 藤井俊光, 渡辺守
    • Journal Title

      日本臨床免疫学会会誌

      Volume: 35 Pages: 99-106

    • NAID

      10030573724

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590934
  • [Journal Article] Identification of novel N-(morpholine-4-carbonyloxy) amidine compounds as potent inhibitors against hepatitis C virus replication2012

    • Author(s)
      Kusano-Kitazume A, Sakamoto N, Okuno Y, Sekine-Osajima Y, Nakagawa M, Kakinuma S, Kiyonashi K, Nitta S, Murakawa M, Azuma S, Nishimura-Sakurai Y, Hagiwara M, Watanabe M
    • Journal Title

      Antimicrob Agent Chemother

      Volume: 56(3) Pages: 1315-1323

    • Data Source
      KAKENHI-PROJECT-21390226
  • [Journal Article] A prospective analysis of the incidence of and risk factors for opportunistic infections in patients with inflammatory bowel disease2012

    • Author(s)
      Naganuma M, Watanabe M(他3名)
    • Journal Title

      J Gastroenterol

      Volume: 48 Pages: 595-600

    • NAID

      10031177010

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590934
  • [Journal Article] 【炎症性腸疾患-病因解明と診断・治療の最新知見-】 総論 炎症性腸疾患の疾患概念と変遷2012

    • Author(s)
      藤井俊光, 渡辺守
    • Journal Title

      日本臨床

      Volume: 70 Pages: 5-9

    • Data Source
      KAKENHI-PROJECT-23590934
  • [Journal Article] Real-time analysis of P-glycoprotein-mediated drug transport across primary intestinal epithelium three-dimensionally cultured in vitro2012

    • Author(s)
      Mizutani T, Nagaishi T, Watanabe M(他11名)
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 419 Pages: 238-243

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590934
  • [Journal Article] NK細胞はIL-7と協調し腸炎惹起性T細胞の分化増殖を抑制する.2012

    • Author(s)
      永石宇司, 渡辺守、 他.
    • Journal Title

      日本臨床免疫学会誌

      Volume: 36

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590936
  • [Journal Article] 特集 図説 胃と腸用語集2012 MREC(MR entero-colonography)2012

    • Author(s)
      藤井俊光, 渡辺守
    • Journal Title

      胃と腸

      Volume: 47 Pages: 668-668

    • Data Source
      KAKENHI-PROJECT-23590934
  • [Journal Article] NK細胞はIL-7と協調し腸炎惹起性T細胞の分化増殖を抑制する.2012

    • Author(s)
      永石宇司, 渡辺守、 他.
    • Journal Title

      日本臨床免疫学会誌

      Volume: 36 Pages: 333-333

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590937
  • [Journal Article] Hepatitis C virus NS4B protein targets STING and abrogates RIG-I-mediated type-I interferon-dependent innate immunity2012

    • Author(s)
      Nitta S, Watanabe M(他13名)
    • Journal Title

      Hepatology

      Volume: 57 Pages: 46-58

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590934
  • [Journal Article] T-helper 17 and interleukin-17-producing lymphoid tissue inducer-like T cells make different contributions to colitis in mice.2012

    • Author(s)
      Ono Y, Kanai T, Sujino T, Nemoto Y, Kanai Y, Mikami Y, Hayashi A, Matsumoto A, Takaishi H, Ogata H, Matsuoka K, Hisamatsu T, Watanabe M, Hibi T.
    • Journal Title

      Gastroenterology.

      Volume: 143 Pages: 1288-1207

    • DOI

      10.1053/j.gastro.2012.07.108

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12J05920, KAKENHI-PROJECT-22590763, KAKENHI-PROJECT-24249046, KAKENHI-PROJECT-24590933, KAKENHI-PROJECT-24659374, KAKENHI-PROJECT-24659375
  • [Journal Article] Identification of novel N-(morpholine-4-carbonyloxy) amidine compounds as potent inhibitors against hepatitis C virus replication2012

    • Author(s)
      Kusano-Kitazume A, Sakamoto N, Okuno Y, Sekine-Osajima Y, Nakagawa M, Kakinuma S, Kiyonashi K, Nitta S, Murakawa M, Azuma S, Nishimura-Sakurai Y, Hagiwara M, Watanabe M
    • Journal Title

      Antimicrob Agent Chemother

      Volume: 56(3) Pages: 1315-23

    • Data Source
      KAKENHI-PROJECT-21590833
  • [Journal Article] IBDとサイトカイン-ケモカイン2012

    • Author(s)
      鈴木雅博、永石宇司、渡辺守
    • Journal Title

      G.I.Research

      Volume: 20(5) Pages: 53-64

    • Data Source
      KAKENHI-PROJECT-22590696
  • [Journal Article] Luminal CD4+ T cells penetrate gut epithelial monolayers and egress from lamina propria to blood circulation.2012

    • Author(s)
      Nemoto Y, Watanabe M
    • Journal Title

      Gastroenterology.

      Volume: 141 Pages: 2030-2039

    • DOI

      10.1053/j.gastro.2011.08.035

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590804, KAKENHI-PROJECT-21590805, KAKENHI-PUBLICLY-22117508, KAKENHI-PROJECT-22229005, KAKENHI-PROJECT-22590694, KAKENHI-PROJECT-22590695, KAKENHI-PUBLICLY-23130506, KAKENHI-PROJECT-23659394, KAKENHI-PROJECT-23790777
  • [Journal Article] 慢性大腸炎モデルにおける腸炎惹起性T細胞の増殖はIL-7とNK細胞により制御される2012

    • Author(s)
      永石宇司、渡辺 守、他
    • Journal Title

      消化器と免疫

      Volume: in press

    • Data Source
      KAKENHI-PROJECT-24590937
  • [Journal Article] 慢性大腸炎モデルにおける腸炎惹起性T細胞の増殖はIL-7とNK細胞により制御される2012

    • Author(s)
      永石宇司、渡辺 守、他
    • Journal Title

      消化器と免疫

      Volume: in press

    • Data Source
      KAKENHI-PROJECT-24590936
  • [Journal Article] Real-time analysis of P- gly coprotei n- mediated drug transport across primary intestinal epithelium three-dimensionally cultured in vitro2012

    • Author(s)
      Mizutani T, Nakamura T, et al
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 419 Pages: 238-243

    • DOI

      10.1016/j.bbrc.2012.01.155

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590803, KAKENHI-PROJECT-21590805, KAKENHI-PUBLICLY-22117508, KAKENHI-PROJECT-22229005, KAKENHI-PROJECT-22590694, KAKENHI-PROJECT-22590695, KAKENHI-PROJECT-22590696, KAKENHI-PLANNED-23102003, KAKENHI-PUBLICLY-23130506, KAKENHI-PROJECT-23590934, KAKENHI-PROJECT-23659394, KAKENHI-PROJECT-23790777, KAKENHI-PROJECT-24390186, KAKENHI-PROJECT-24590936, KAKENHI-PROJECT-24590937, KAKENHI-PUBLICLY-24112508
  • [Journal Article] 炎症性腸疾患の疾患概念と変遷2012

    • Author(s)
      藤井俊光, 渡辺守
    • Journal Title

      日本臨床

      Volume: 70 Pages: 5-9

    • Data Source
      KAKENHI-PROJECT-23590934
  • [Journal Article] 免疫調節薬/分子生物製剤を用いた難治性潰瘍性大腸炎に対する治療戦略2012

    • Author(s)
      藤井俊光, 渡辺守
    • Journal Title

      消化器内科

      Volume: 54 Pages: 28-33

    • Data Source
      KAKENHI-PROJECT-23590934
  • [Journal Article] Real-time analysis of P-glycoprotein-mediated drug transport across primary intestinal epithelium three-dimensionally cultured in vitro2012

    • Author(s)
      Mizutani T, Nakamura T, Morikawa R, Fukuda M, Mochizuki W, Yamauchi Y, NozakiK, Yui S, Nemoto Y, Nagaishi T, Okamoto R, Tsuchiya K, and Watanabe M
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 419(2) Pages: 238-243

    • Data Source
      KAKENHI-PROJECT-21590805
  • [Journal Article] Real-time analysis of P-glycoprotein-mediated drug transport across primary intestinal epithelium three-dimensionally cultured in vitro2012

    • Author(s)
      Mizutani T, Nakamura T, Nagaishi T, Okamoto R, Watanabe M, et al
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 419 Pages: 238-243

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590806
  • [Journal Article] The use of traditional and newer calcineurin inhibitors in inflammatory bowel disease2012

    • Author(s)
      Naganuma M, Fujii T, Watanabe M
    • Journal Title

      J Gastroenterol

      Volume: 46 Pages: 129-37

    • NAID

      10029026934

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590934
  • [Journal Article] The development of colitogenic CD4+T cells is regulated by IL-7 in collaboration with natural killer cell function in a murine model of colitis2012

    • Author(s)
      Nagaishi T, Yamaji O, Okamoto R, Watanabe M, et al
    • Journal Title

      J Immunol

      Volume: 188 Pages: 2524-2536

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590806
  • [Journal Article] Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell2012

    • Author(s)
      Yui S, Nakamura T, Watanabe M, et al.
    • Journal Title

      Nature Medicine

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229005
  • [Journal Article] Suppression ofhath1 gene expression directly regulated by hes1 via notch signaling is associated with goblet cell depletion in ulcerative colitis.2012

    • Author(s)
      Zheng X, Nakamura T, et al
    • Journal Title

      Inflamm Bowel Di

      Volume: 17 Pages: 2251-2260

    • DOI

      10.1002/ibd.21611

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590805, KAKENHI-PUBLICLY-22117508, KAKENHI-PROJECT-22229005, KAKENHI-PROJECT-22590694, KAKENHI-PROJECT-22590695, KAKENHI-PUBLICLY-23130506, KAKENHI-PROJECT-23790777, KAKENHI-PROJECT-24659359
  • [Journal Article] Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell2012

    • Author(s)
      Yui S, Nagaishi T, Watanabe M(他9名)
    • Journal Title

      Nat Med

      Volume: 18 Pages: 618-623

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590934
  • [Journal Article] Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5(+) stem cell.2012

    • Author(s)
      Yui S, Nakamura T, Sato T, Nemoto Y, Mizutani T, Zheng X, Ichinose S, Nagaishi T, Okamoto R, Tsuchiya K, Clevers H, and Watanabe M
    • Journal Title

      Nat. Med.

      Volume: 18 Pages: 618-23

    • DOI

      10.1038/nm.2695

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590803, KAKENHI-PROJECT-21590805, KAKENHI-PROJECT-21590806, KAKENHI-PUBLICLY-22117508, KAKENHI-PROJECT-22229005, KAKENHI-PROJECT-22590694, KAKENHI-PROJECT-22590695, KAKENHI-PROJECT-22590696, KAKENHI-PLANNED-23102003, KAKENHI-PUBLICLY-23130506, KAKENHI-PROJECT-23590934, KAKENHI-PROJECT-23659394, KAKENHI-PROJECT-23790777, KAKENHI-PROJECT-23890204, KAKENHI-PROJECT-24390186, KAKENHI-PROJECT-24590936, KAKENHI-PROJECT-24590937, KAKENHI-PROJECT-24689036, KAKENHI-PROJECT-24790684, KAKENHI-PUBLICLY-24112508, KAKENHI-PUBLICLY-24112523
  • [Journal Article] Luminal CD4+ T cells penetrate gut epithelial monolayers and egress from lamina propria to blood circulation2011

    • Author(s)
      Nemoto Y, Watanabe M(他8名)
    • Journal Title

      Gastroenterology

      Volume: 141 Pages: 2130-2139

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590934
  • [Journal Article] 腹部症状発現メカニズム解明への臨床的アプローチ:腸内細菌、炎症と腹部症状.2011

    • Author(s)
      永石宇司、山地統、渡辺守
    • Journal Title

      Modern Physician

      Volume: 31 Pages: 310-313

    • Data Source
      KAKENHI-PROJECT-21590806
  • [Journal Article] Studies on virus kineticsusing infectious fluorescence-taggedhepatitis C virus cell culture.2011

    • Author(s)
      Yamamoto M, Sakamoto N, Nakamura T, Itsui Y, Nakagawa M, Nishimura-Sakurai Y, Kakinuma S, Azuma S, Kato T, Wakita T, Watanabe M
    • Journal Title

      Hepatology Research

      Volume: 41 Pages: 258-269

    • DOI

      10.1111/j.1872-034x.2010.00771.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-21590832, KAKENHI-PROJECT-22790633, KAKENHI-PROJECT-23790778
  • [Journal Article] Upregulated IL-7Rαexpression on colitogenic memory CD4+ T cells may participate in the development and persistence of chronic colitis2011

    • Author(s)
      Shinohara T, Watanabe M(他8名)
    • Journal Title

      J Immunol

      Volume: 186 Pages: 2623-2632

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590934
  • [Journal Article] Studies on virus kinetics using infectious fluorescence-tagged hepatitis C virus cell culture2011

    • Author(s)
      Yamamoto M, Sakamoto N, Nakamura T, Itsui Y, Nakagawa M, Nishimura-Sakurai Y, Kakinuma S, Azuma S, Tsuchiya K, Kato T, Wakita T, Watanabe M
    • Journal Title

      Hepatol Res

      Volume: 41 Pages: 258-269

    • Data Source
      KAKENHI-PROJECT-21390226
  • [Journal Article] Target biopsy or step biopsy? Optimal surveillance for ulcerative colitis : a Japanese nationwide randomized controlled trial2011

    • Author(s)
      Watanabe T, Nagahori M, Watanabe M, et al
    • Journal Title

      J Gastroenterol

      Volume: 46 Pages: 11-16

    • NAID

      10029029994

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590806
  • [Journal Article] Longitudinal cell formation in the entire human small intestine is correlated with the localization of Hath1 and Klf4.2011

    • Author(s)
      Iwasaki M, Tsuchiya K, Suzuki S, Watanabe M, et al
    • Journal Title

      J Gastroenterol.

      Volume: 46 Pages: 191-202

    • DOI

      10.1007/s00535-010-0346-x

    • NAID

      10029027237

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590805, KAKENHI-PROJECT-22590694, KAKENHI-PROJECT-22590695, KAKENHI-PUBLICLY-23130506, KAKENHI-PROJECT-23790777
  • [Journal Article] Analysis of the complete open reading frame of hepatitis C virus in genotype 2a infection reveals critical sites influencing the response to peginterferon and ribavirin therapy2011

    • Author(s)
      Kadokura M, Nakagawa M, Sakamoto N, Watanabe M, et al.
    • Journal Title

      Hepatol Int.

      Volume: 5(3) Pages: 789-799

    • DOI

      10.1007/s12072-011-9267-x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226, KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-21590832, KAKENHI-PROJECT-21590837, KAKENHI-PROJECT-22659145, KAKENHI-PROJECT-24659359
  • [Journal Article] Magnetic resonance enterocolonography is useful for simultaneous evaluation of small and large intestinal lesions in Crohn's disease2011

    • Author(s)
      Hyun SB, Nagahori M, Araki A, Watanabe M, et al
    • Journal Title

      Inflamm Bowel Dis

      Volume: 11 Pages: 1063-1072

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590806
  • [Journal Article] 分泌メディエーターはヒトマクロファージにおけるNod2誘導性寛容を調節する2011

    • Author(s)
      永石宇司、渡辺守
    • Journal Title

      Review of Gastroenterology & Clinical Gastroenterology and Hepatology

      Volume: 6(2) Pages: 12-16

    • Data Source
      KAKENHI-PROJECT-22590696
  • [Journal Article] Magnetic resonance enterocolonography is useful for simultaneous evaluation of small and large intestinal lesions in Crohn's disease.2011

    • Author(s)
      Hyun SB, Kitazume Y, Suzuki S, Watanabe M, et al
    • Journal Title

      Inflamm Bowel Dis.

      Volume: 17 Pages: 1063-1072

    • DOI

      10.1002/ibd.21510

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590805, KAKENHI-PROJECT-21590806, KAKENHI-PROJECT-22590694, KAKENHI-PROJECT-22590695, KAKENHI-PROJECT-22590696, KAKENHI-PUBLICLY-23130506, KAKENHI-PROJECT-23590934
  • [Journal Article] 分泌メディエーターはヒトマクロファージにおけるNod2誘導性寛容を調節する2011

    • Author(s)
      永石宇司、渡辺守
    • Journal Title

      Review of Gastroenterology & Clinical Gastro-enterology and Hepatology

      Volume: 6(2) Pages: 12-16

    • Data Source
      KAKENHI-PROJECT-21590806
  • [Journal Article] Cholestatic liver fibrosis and toxin-induced fibrosis are exacerbated in matrix metalloproteinase-2 deficient mice2011

    • Author(s)
      Kakinuma S, Onozuka I, Kamiya A, Miyoshi M, Sakamoto N, Kiyohashi K, Watanabe T, Funaoka Y, Ueyama M, NakagawaM, Koshikawa N, Seiki M, Nakauchi H, and Watanabe M
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 406 Pages: 134-140

    • Data Source
      KAKENHI-PROJECT-21590833
  • [Journal Article] Safety and usefulness of balloon endoscopy in Crohn's disease patients with postoperative ileal lesions2011

    • Author(s)
      Naganuma M, Watanabe M, Hibi T
    • Journal Title

      J Crohns Colitis

      Volume: 5 Pages: 73-74

    • DOI

      10.1016/j.crohns.2010.10.003

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590806, KAKENHI-PROJECT-22590696
  • [Journal Article] Longitudinal cell formation in the entire human small intestine is correlated with the localization of Hath1 and Klf4.2011

    • Author(s)
      Iwasaki M, Watanabe M, et al.
    • Journal Title

      J Gastroenterol

      Volume: 46 Pages: 191-202

    • NAID

      10029027237

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-22117508
  • [Journal Article] Luminal CD4+T cells penetrate gut epithelial monolayers and egress from lamina propria to blood circulation2011

    • Author(s)
      Nemoto Y, Watanabe M
    • Journal Title

      Gastroenterology

      Volume: 141 Pages: 2130-2139

    • Data Source
      KAKENHI-PROJECT-21590804
  • [Journal Article] 長期予後の面からみたクローン病に対する免疫調節薬の有用性2011

    • Author(s)
      長沼誠, 藤井俊光, 渡辺守
    • Journal Title

      日本消化器病学会雑誌

      Volume: 108 Pages: 388-400

    • NAID

      10030296443

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590934
  • [Journal Article] Association of IL28B polymorphism withresponse to pegylated-interferon alpha plusribavirin combination therapy in patientswith chronic genotype 2 hepatitis C2011

    • Author(s)
      Sakamoto N, Nakagawa M, Tanaka Y, Sekine-Osajima Y, Ueyama M, Kurosaki M, Nishida N, Tamori A, Nishimura-Sakurai Y, Itsui Y, Azuma S, Kakinuma S, Hige S, Ito Y, Tanaka E, Hiasa Y, Izumi N, Tokunaga K, Mizokami M, Watanabe M
    • Journal Title

      JMedical Virol

      Volume: 83 Pages: 871-878

    • Data Source
      KAKENHI-PROJECT-21590833
  • [Journal Article] The inhibitory effect on hepatitis C virus infection of a triterpenoid compound, with or without interferon-alpha2011

    • Author(s)
      Watanabe T, Sakamoto N, Nakagawa M, Kakinuma S, Itsui Y, Nishimura-Sakurai Y, Ueyama M, Funaoka Y, Kitazume A, Nitta S, Kiyohashi K, Murakawa M, Azuma S, Tsuchiya K, Oooka S, Watanabe M
    • Journal Title

      Antimicrob Agents Chemother

      Volume: 55(6) Pages: 2537-2545

    • Data Source
      KAKENHI-PROJECT-21590832
  • [Journal Article] Pre-treatment prediction of response topegylated-interferon plus ribavirin forchronic hepatitis C using genetic polymorphism in IL28B and viral factors2011

    • Author(s)
      Kurosaki M, Tanaka Y, Nishida N, Sakamoto N, Enomoto N, Honda M, SugiyamaM, Matsuura K, Sugauchi F, Asahina Y, Nakagawa M, Watanabe M, Sakamoto M, Maekawa S, Sakai A, Kaneko S, Ito K, Masaki N, Tokunaga K, Izumi N, Mizokami M
    • Journal Title

      JHepatol

      Volume: 54 Pages: 439-448

    • Data Source
      KAKENHI-PROJECT-21590833
  • [Journal Article] Longitudinal cell formation in the entire human smallintestine is correlated with the localization of Hathl and K1f4.2011

    • Author(s)
      Iwasaki M, Nakamura T, Watanabe M, etal.
    • Journal Title

      J Gastroenterol

      Volume: 46 Pages: 191-202

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229005
  • [Journal Article] Analysis of interferon signaling by infectious hepatitis C virus clones with substitutions of core amino acids 70 and 912011

    • Author(s)
      Funaoka Y, Sakamoto N, Suda G, Itsui Y, Nakagawa M, Kakinuma S, Watanabe T, Nitta S, Kitazume A, Kiyohashi K, Murakawa M, Azuma S, Tsuchiya K,Watanabe M
    • Journal Title

      J Virol

      Volume: 85 Pages: 5986-5994

    • DOI

      10.1128/jvi.02583-10

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-21590832, KAKENHI-PROJECT-22790633, KAKENHI-PUBLICLY-23130506
  • [Journal Article] 腹部症状発現メカニズム解明への臨床的アプローチ:腸内細菌、炎症と腹部症状2011

    • Author(s)
      永石宇司、山地統、渡辺守
    • Journal Title

      Modern Physician

      Volume: 31 Pages: 310-313

    • Data Source
      KAKENHI-PROJECT-22590696
  • [Journal Article] The inhibitory effect on hepatitis C virus infection of a triterpenoid compound, with or without interferon-alpha2011

    • Author(s)
      Watanabe T, Sakamoto N, Nakagawa M, Kakinuma S, Itsui Y, Nishimura-Sakurai Y, Ueyama M, Funaoka Y, Kitazume A, Nitta S, Kiyohashi K, Murakawa M, Azuma S, Tsuchiya K, Oooka S, Watanabe M
    • Journal Title

      Antimicrob Agents Chemother

      Volume: 55(6) Pages: 2537-2545

    • Data Source
      KAKENHI-PROJECT-21390226
  • [Journal Article] 【クローン病の長期予後改善をめざして】長期予後の面からみたクローン病に対する免疫調節薬の有用性2011

    • Author(s)
      長沼誠,藤井俊光,渡辺守
    • Journal Title

      日本消化器病学会雑誌

      Volume: 108巻3号 Pages: 388-400

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590934
  • [Journal Article] Analysis of the complete open reading frame of genotype 2b hepatitis C virus inassociation with the response to peginterferon and ribavirin therapy2011

    • Author(s)
      Kadokura M, Maekawa S, Sueki R, Miura M, Komase K, Shindo H, Amemiya F, Uetake T, Inoue T, Sakamoto M, Nakagawa M, Sakamoto N, Watanabe M, Enomoto N
    • Journal Title

      PLoSOne

      Volume: 6(9)

    • Data Source
      KAKENHI-PROJECT-21390226
  • [Journal Article] Serum interleukin-6 levels can predict resistance to treatment of chronic hepatitis C infection with pegylated-interferon alpha 2b plus ribavirin2011

    • Author(s)
      Ueyama M, Nakagawa M, Sakamoto N, Onozuka I, Funaoka Y, Watanabe T, Nitta S, Kiyohashi K, Kitazume A, Murakawa M, Nishimura-Sakurai Y, Sekine-Osajima Y, Itsui Y, Azuma S, Kakinuma S, Watanabe M
    • Journal Title

      Antivir Ther

      Volume: 16 Pages: 1081-1091

    • Data Source
      KAKENHI-PROJECT-21590833
  • [Journal Article] ここまでわかった自己免疫疾患-Crohn病・潰瘍性大腸炎2011

    • Author(s)
      鈴木雅博、永石宇司、渡辺守
    • Journal Title

      臨床検査臨時増刊号

      Volume: 55(11) Pages: 1258-1264

    • Data Source
      KAKENHI-PROJECT-21590806
  • [Journal Article] The use of traditional and newer calcineurin inhibitors in inflammatory bowel disease.2011

    • Author(s)
      Naganuma M, Watanabe M, Hibi T
    • Journal Title

      J Gastroenterol.

      Volume: 46 Pages: 129-137

    • DOI

      10.1007/s00535-010-0352-z

    • NAID

      10029026934

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590806, KAKENHI-PROJECT-22590696, KAKENHI-PROJECT-23590934
  • [Journal Article] Analysis of interferon signaling by infectious hepatitis C virus clones with substitutions of core amino acids 70 and 912011

    • Author(s)
      Funaoka Y, Sakamoto N, Suda G, Itsui Y, Nakagawa M, Kakinuma S, Watanabe T, Nitta S, Kitazume A, Kiyohashi K, Murakawa M, Azuma S, Tsuchiya K, Watanabe M
    • Journal Title

      J Virol

      Volume: 85 Pages: 5986-94

    • Data Source
      KAKENHI-PROJECT-21590833
  • [Journal Article] Upretulated IL-7 receptor (alpha) expression on colitogenicmemory CD4+ T cells may participate in the developmentand persistence of chronic colitis.2011

    • Author(s)
      Shinohara T, Nakamura T, Watanabe M, etal.
    • Journal Title

      Journal of Immunology

      Volume: 186 Pages: 2623-2632

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229005
  • [Journal Article] Magnetic resonance enterocolonography is useful for simultaneous evaluation of small and large intestinall esions in Crohn's disease.2011

    • Author(s)
      Hyun SB, Kitazume Y, Nagahori M, Toriihara A, Fujii T, Tsuchiya K, Suzuki S, Okada E, Araki A, Naganuma M, Watanabe M
    • Journal Title

      Inflamm Bowel Dis.

      Volume: In press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590805
  • [Journal Article] ここまでわかった自己免疫疾患-Crohn 病・潰瘍性大腸炎2011

    • Author(s)
      鈴木雅博、永石宇司、渡辺守
    • Journal Title

      臨床検査臨時増刊号

      Volume: 55(11) Pages: 1258-1264

    • Data Source
      KAKENHI-PROJECT-22590696
  • [Journal Article] Analysis of interferon signaling by infectious hepatitis C virus clones with substitutions of core amino acids 70 and 912011

    • Author(s)
      Funaoka Y, Sakamoto N, Kakinuma S, Azuma S, Watanabe M, et al
    • Journal Title

      Journal of Virology

      Volume: 85 Pages: 5986-94

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590833
  • [Journal Article] Analysis of interferon signaling by infectious hepatitis C virus clones with substitutions of core amino acids 70 and 912011

    • Author(s)
      Funaoka Y, Sakamoto N, Nakagawa M, Kakinuma S, Suda S, Watanabe T, Nitta S, Kitazume A, Kiyohashi K, Murakawa M, Azuma S, Tsuchiya K, and Watanabe M
    • Journal Title

      J Virol

      Volume: 85(12) Pages: 5986-5994

    • Data Source
      KAKENHI-PROJECT-21390226
  • [Journal Article] Upretulated IL-7 receptor (alpha) expression on colitogenic memory CD4+ T cells may participate in the development and persistence of chronic colitis.2011

    • Author(s)
      Shinohara T, Watanabe M, et al.
    • Journal Title

      Journal of Immunology

      Volume: 186 Pages: 2623-2632

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-22117508
  • [Journal Article] Suppression of hathl gene expression directly regulated by hesl via notch signaling is associated with goblet celldepletion in ulcerative colitis.2011

    • Author(s)
      Zheng X, Nakamura T, Watanabe M, et al.
    • Journal Title

      Inflamm Bowel Dis.

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229005
  • [Journal Article] Upregulated IL-7 receptor (alpha) expression on colitogenic memory CD4+ T cells may participate in the development and persistence of chronic colitis.2011

    • Author(s)
      Shinohara T, Nemoto Y Watanabe M, et al.
    • Journal Title

      J Immunol. 186

      Pages: 2623-2632

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590736
  • [Journal Article] Inhibitory effect of a triterpenoid compound, with or without interferon-alpha, on hepatitis C virus infection2011

    • Author(s)
      Watanabe T, Sakamoto N, Nakagawa M, Azuma S, Watanabe M, et al.
    • Journal Title

      Antimicrobial Agents and Chemotherapy

      Volume: 55(6) Pages: 2537-2545

    • DOI

      10.1128/aac.01780-10

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226, KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-21590832, KAKENHI-PROJECT-22659145, KAKENHI-PROJECT-22790633, KAKENHI-PUBLICLY-23130506, KAKENHI-PROJECT-23790778
  • [Journal Article] Analysis of interferon signaling by infectious hepatitis C virus clones with substitutions of core amino acids 70 and 912011

    • Author(s)
      Funaoka Y, Watanabe M(他11名)
    • Journal Title

      J Virol

      Volume: 85 Pages: 5986-5994

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590934
  • [Journal Article] 腹部症状発現メカニズム解明への臨床的アプローチ:腸内細菌、炎症と腹部症状2011

    • Author(s)
      永石宇司、山地統、渡辺守
    • Journal Title

      Modern Physician 31

      Pages: 311-313

    • Data Source
      KAKENHI-PROJECT-20590737
  • [Journal Article] Upregulated IL-7Rα expression on colitogenic memory CD4+ T cells may participate in the development and persistence of chronic colitis2011

    • Author(s)
      Shinohara, T., et al
    • Journal Title

      J Immunol

      Volume: 186 Pages: 2623-2632

    • DOI

      10.4049/jimmunol.1000057

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590531, KAKENHI-PROJECT-21590805, KAKENHI-PUBLICLY-22117508, KAKENHI-PROJECT-22229005, KAKENHI-PROJECT-22590694, KAKENHI-PROJECT-22590695, KAKENHI-PUBLICLY-23130506
  • [Journal Article] Upregulated IL-7R α expression on colitogenic memory CD4+ T cells may participate in the development and persistence of chronic colitis2011

    • Author(s)
      Shinohara T, Nemoto Y, Kanai T, Kameyama K, Okamoto R, Tsuchiya K, Nakamura T, Totsuka T, Ikuta K, Watanabe M
    • Journal Title

      J Immunol

      Volume: 186 Pages: 2623-2632

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659394
  • [Journal Article] Longitudinal cell formation in the entire human small intestine is correlated with the localization of Hathl and KIN.2011

    • Author(s)
      Iwasaki M, Tsuchiya K, Araki A, Watanabe M, et al.
    • Journal Title

      J Gastroenterol.

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590694
  • [Journal Article] 腹部癌状発現メカニズム解明への臨床的アプローチ:腸内細菌、炎症と腹部症状2011

    • Author(s)
      永石宇司、山地統、渡辺守
    • Journal Title

      Modern Physician

      Volume: 31 Pages: 311-313

    • Data Source
      KAKENHI-PROJECT-20590737
  • [Journal Article] Suppression of hath1 gene expression directly regulated by hes1 via notch signaling is associated with goblet cell depletion in ulcerative colitis2011

    • Author(s)
      Zheng X, Watanabe M(他6名)
    • Journal Title

      Inflamm Bowel Dis

      Volume: 11 Pages: 2251-2260

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590934
  • [Journal Article] Cholestatic liver fibrosis and toxin-induced fibrosis are exacer bated in matrix metalloproteinase-2 deficient mice2011

    • Author(s)
      Onozuka I, Sakamoto N, Nakagawa M, Watanabe M, et al.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 406 Pages: 134-140

    • DOI

      10.1016/j.bbrc.2011.02.012

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226, KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-21590832, KAKENHI-PROJECT-22591762, KAKENHI-PROJECT-22659145, KAKENHI-PUBLICLY-23117507, KAKENHI-PROJECT-23689040
  • [Journal Article] Longitudinal cell formation in the entire human small intestine is correlated with the localization of Hath1 and Klf42011

    • Author(s)
      Iwasaki M, Tsuchiya K, Okamoto R, ZhengX, Kano Y, Okamoto E, Okada E, Araki A, Suzuki S, Sakamoto N, Kitagaki K, Akashi T, Eishi Y, Nakamura T, Watanabe M
    • Journal Title

      J Gastroenterol

      Volume: 46(2) Pages: 191-202

    • NAID

      10029027237

    • Data Source
      KAKENHI-PROJECT-21590805
  • [Journal Article] Analysis of the complete open reading frame of genotype 2b hepatitis C virus in association with the response to peginterferon and ribavirin therapy2011

    • Author(s)
      Kadokura M, Maekawa S, Sueki R, Miura M, Komase K, Shindo H, Amemiya F, Uetake T, Inoue T, Sakamoto M, Nakagawa M, Sakamoto N, Watanabe M, Enomoto N
    • Journal Title

      PLoS One

      Volume: 6(9)

    • Data Source
      KAKENHI-PROJECT-21590833
  • [Journal Article] Serum interleukin-6 levels can predict resistance to treatment of chronic hepatitis C infection with pegylated-interferon alpha 2b plus ribavirin.2011

    • Author(s)
      Mayumi Ueyama, Mina Nakagawa, Naova Sakamoto, Seishin Azuma, Mamoru Watanabe, et al.
    • Journal Title

      Antivral Therapy

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226
  • [Journal Article] Inhibitory effect of triterpenoid compound, with or without interferon-alpha, on hepatitis C virus infection2011

    • Author(s)
      Watanabe T, Sakamoto N, Nakagawa M, Kakinuma S, Itsui Y, Nishimura-Sakurai Y, Ueyama M, Funaoka Y, Kitazume A, Nitta S, Kiyohashi K, Murakawa M, Azuma S, Tsuchiya K, Oooka S, Watanabe M
    • Journal Title

      Antimicrob Agent Chemother

      Volume: 55 Pages: 2537-45

    • Data Source
      KAKENHI-PROJECT-21590833
  • [Journal Article] Suppression of hathl gene expression directly regulated byhesl via notch signaling is associated with goblet cell depletion in ulcerative colitis.2011

    • Author(s)
      Zheng X, Watanabe M, et al.
    • Journal Title

      Inflamm Bowel Dis.

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-22117508
  • [Journal Article] Pretreatment Prediction of Response to Pegylated-Interferon Plus Ribavirin for Chronic Hepatitis C using Genetic Polymorphism in IL28B and Viral Factors2011

    • Author(s)
      Kurosaki M, Sakamoto N, Nakagawa M, Watanabe M, et al.
    • Journal Title

      J Hepatol.

      Volume: 54 Pages: 439-448

    • DOI

      10.1016/j.jhep.2010.07.037

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226, KAKENHI-PROJECT-21390227, KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-21590832, KAKENHI-PROJECT-21590836, KAKENHI-PROJECT-21590837, KAKENHI-PROJECT-22659145, KAKENHI-PROJECT-22790633, KAKENHI-PROJECT-23390117
  • [Journal Article] Longtudinal cell formation in the entire human small intestine is correlated with the localization of Hathl and KIM2011

    • Author(s)
      Iwasaki M, Tsuchiya K, Okamoto R, Zheng X, Kano Y, Okamoto E, Okada E, Araki A, Suzuki S, Sakamoto N, Kitagaki K, Akashi T, Eishi Y, Nakamura T, Watanabe__M
    • Journal Title

      J Gastroenterol.

      Volume: 46 Pages: 191-202

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590805
  • [Journal Article] Suppression of Hath1 gene expression directly regulated by Hes1 via Notch signaling is associated with goblet cell depletion in ulcerative colitis2011

    • Author(s)
      Zheng X, Tsuchiya K, Okamoto R, Iwasaki M, Kano Y, Sakamoto N, Nakamura T, Watanabe M
    • Journal Title

      Inflamm Bowel Dis

      Volume: 17(11) Pages: 2251-2260

    • Data Source
      KAKENHI-PROJECT-21590803
  • [Journal Article] Association of IL28B variants with response to pegylated-interferon alphaplus ribavirin combination therapy reveals intersubgenotypic differences between genotypes 2a and 2b.2011

    • Author(s)
      Sakamoto N, Nakagawa M, Azuma S, Watanabe M, et al.
    • Journal Title

      J Medical Viro

      Volume: 83 Pages: 871-8

    • DOI

      10.1002/jmv.22038

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226, KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-21590832, KAKENHI-PROJECT-21590833, KAKENHI-PROJECT-22390151, KAKENHI-PROJECT-22659145, KAKENHI-PROJECT-22710191, KAKENHI-PROJECT-22790633, KAKENHI-PROJECT-23390117, KAKENHI-PROJECT-23790778
  • [Journal Article] Conception and pregnancy outcome in women with inflammatory bowel disease: A multicentre study from Japan2011

    • Author(s)
      Naganuma M, Nagahori M, Watanabe M, et al
    • Journal Title

      J Crohns Colitis

      Volume: 5 Pages: 317-323

    • DOI

      10.1016/j.crohns.2011.02.003

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590806, KAKENHI-PROJECT-22590696
  • [Journal Article] Analysis of the complete open reading frame of genotype 2b hepatitis C virus in association with the response to peginterferon and ribavirin therapy2011

    • Author(s)
      Kadokura M, Nakagawa M, Sakamoto N, Watanabe M, et al.
    • Journal Title

      PLoS One.

      Volume: 6(9)

    • DOI

      10.1371/journal.pone.0024514

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226, KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-21590832, KAKENHI-PROJECT-21590837, KAKENHI-PROJECT-21659186, KAKENHI-PROJECT-22659145, KAKENHI-PROJECT-23390195
  • [Journal Article] MR enterocolonography is useful for simultaneous evaluation of small and large intestinal lesions in Crohn's disease2011

    • Author(s)
      Hyun SB, Kitazume Y, Nagahori M, Toriihara A, Fujii T, Tsuchiya K, Suzuki S, Okada E, Araki A, Naganuma M, Watanabe M
    • Journal Title

      Inflam Bowel Dis

      Volume: 17(5) Pages: 1063-1072

    • Data Source
      KAKENHI-PROJECT-21590805
  • [Journal Article] Suppression of Hath1 gene expression directly regulated by Hes1 via Notch signaling is associated with goblet cell depletion in ulcerative colitis2011

    • Author(s)
      Zheng X, Tsuchiya K, Okamoto R, Iwasaki M, Kano Y, Sakamoto N, Nakamura T, Watanabe M
    • Journal Title

      Inflamm Bowel Dis

      Volume: 17(11) Pages: 2251-2260

    • Data Source
      KAKENHI-PROJECT-21590805
  • [Journal Article] A new method for induced fit docking(GENIUS) and its application to virtual screening of novel HCV NS3-4A protease inhibitors2011

    • Author(s)
      Takaya D, Yamashita A, Kamijo K, Gomi J, Ito M, Maekawa S, Enomoto N, SakamotoN, Watanabe Y, Arai R, Umeyama H, Honma T, Matsumoto T, Yokoyama S
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 19(22) Pages: 6892-6905

    • Data Source
      KAKENHI-PROJECT-21390226
  • [Journal Article] Longitudinal cell formation in the entire human small intestine is correlated with the localization of Hath1 and Klf42011

    • Author(s)
      Iwasaki M, Tsuchiya K, Okamoto R, Zheng X, Kano Y, Okamoto E, Okada E, Araki A, Suzuki S, Sakamoto N, Kitagaki K, Akashi T, Eishi Y, Nakamura T, Watanabe M
    • Journal Title

      J Gastroenterol

      Volume: 46(2) Pages: 191-201

    • NAID

      10029027237

    • Data Source
      KAKENHI-PROJECT-21590803
  • [Journal Article] Cell culture and in-vivo analyses of plaque-derived cytopathic hepatitis C virus mutants.2010

    • Author(s)
      Mishima K, Watanabe M, et al.
    • Journal Title

      Virology.

      Volume: 405 Pages: 361-369

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-22117508
  • [Journal Article] Cell culture and in-vivo analyses of plaque-derived cytopathic hepatitis C virus mutants2010

    • Author(s)
      Mishima K, Sakamoto N, Sekine-Osajima Y, Nakagawa M, Itsui Y, Azuma S, Kakinuma S, Tuchiya K, Imamura M, Chayama K, Wakita T, Watanabe M
    • Journal Title

      Virology

      Volume: 405 Pages: 361-369

    • Data Source
      KAKENHI-PROJECT-21590833
  • [Journal Article] Cell culture and in-vivo analyses of plaque-derivedcytopathic hepatitis C virus mutants.2010

    • Author(s)
      Mishima K, Nakamura T, Watanabe M, etal.
    • Journal Title

      Virology.

      Volume: 405 Pages: 361-369

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229005
  • [Journal Article] MR enterocolonography is useful for simultaneous evaluation ofsmall and large intestinal lesions in Crohn's disease.2010

    • Author(s)
      Hyun SB, Naganuma M, Watanabe M, et al.
    • Journal Title

      Inflam Bowel Dis

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590696
  • [Journal Article] IL-2 is positively involved in the development of colitogenic CD4+IL-7R alpha high memory T cells in chronic colitis2010

    • Author(s)
      Kameyama K, Totsuka T, Watanabe M, et al
    • Volume
      183
    • Pages
      2423-2436
    • Data Source
      KAKENHI-PROJECT-21590804
  • [Journal Article] ITPA gene variant protects against anemia induced by pegylated interferon-alfa and ribavirin therapy for Japanese patients with chronic hepatitis C2010

    • Author(s)
      Sakamoto N, Tanaka Y, Nakagawa M, Yatsuhashi H, Nishiguchi S, Enomoto N, Azuma S, Nishimura-Sakurai Y, Kakinuma S, Nishida N, Tokunaga K, Honda M, Ito K, Mizokami M, Watanabe M
    • Journal Title

      Hepatol Res

      Volume: 40 Pages: 1063-1071

    • Data Source
      KAKENHI-PROJECT-21590833
  • [Journal Article] Inhibition of HCV replication by a specific inhibitor of serin-arginine-rich protein kinase2010

    • Author(s)
      Karakama Y, Sakamoto N, Itsui Y, Nakagawa M, Tasaka-Fujita M, Nishimura-Sakurai Y, Kakinuma S, Oooka S, Azuma S, Tsuchiya K, Onogi H, Hagiwara M, Watanabe M
    • Journal Title

      Antimicrob AgentChemother

      Volume: 54 Pages: 3179-86

    • Data Source
      KAKENHI-PROJECT-21590833
  • [Journal Article] Delta-like 1 expression promotes goblet cell differentiation in Notch-inactivated human colonic epithelial cells.2010

    • Author(s)
      Akiyama J, Watanabe M, et al.
    • Journal Title

      Biochemical and Biophysical Research Communications. (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19209027
  • [Journal Article] IL-6-mediated intersubgenotypic variation of interferon sensitivity in hepatitis C virus genotype 2a/2b chimeric clones2010

    • Author(s)
      Suda G, Sakamoto N, Itsui Y, Nakagawa M, Mishima K, Onuki-Karakama Y, Yamamoto M, Funaoka Y, Watanabe T, Kiyohashi K, Nitta S, Azuma S, Kakinuma S, Tuchiya K, Imamura M, Hiraga N, Chayama K, Watanabe M
    • Journal Title

      Virology

      Volume: 407 Pages: 80-90

    • Data Source
      KAKENHI-PROJECT-21590833
  • [Journal Article] IL-2 is positively involved in the development of colitogenic CD4+ IL-7R alpha high memory T cells inchronic colitis.2010

    • Author(s)
      Kameyama K, Nakamura T, Watanabe M, et al.
    • Journal Title

      Eur J Immunol.

      Volume: 40 Pages: 2423-2436

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229005
  • [Journal Article] SR蛋白リン酸化酵素阻害剤によるHCV増殖抑制効果の解析2010

    • Author(s)
      唐鎌優子、坂本直哉、井津井康浩、中川美奈、藤田めぐみ、櫻井幸、柿沼晴、大岡真也、東正新、土屋輝一郎、小野木博、萩原正敏、渡辺守
    • Journal Title

      消化器内科

      Volume: 51(6) Pages: 632-635

    • Data Source
      KAKENHI-PROJECT-21590832
  • [Journal Article] Mutations in the interferon sensitivity determining region and virological response to combination therapy with pegylated-interferon alpha 2b plus ribavirin in patients with chronic hepatitis C-1b infection2010

    • Author(s)
      Nakagawa M, Sakamoto N, Ueyama M, Mogushi K, Nagaie S, Itsui Y, Azuma S, Kakinuma S, Tanaka H, Enomoto N, Watanabe M
    • Journal Title

      J Gastroentorol

      Volume: 45 Pages: 656-665

    • NAID

      10027216778

    • Data Source
      KAKENHI-PROJECT-21590833
  • [Journal Article] Cell culture and in vivo analyses of cytopathic hepatitis C virus mutants2010

    • Author(s)
      Mishima K, Sakamoto N, Sekine-Osajima Y, Nakagawa M, Itsui Y, Azuma S, Kakinuma S, Kiyohashi K, Kitazume A, Tsuchiya K, Imamura M, Hiraga N, Chayama K, Wakita T, Watanabe M
    • Journal Title

      Virology

      Volume: 405 Pages: 361-369

    • Data Source
      KAKENHI-PROJECT-21390226
  • [Journal Article] Prevalence of metabolic syndrome is comparable between inflammatory bowel disease patients and the general population.2010

    • Author(s)
      Nagahori M, Naganuma M, Watanabe M, et al.
    • Journal Title

      J Gastroenterol

      Volume: 45 Pages: 1008-1013

    • NAID

      10027699223

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590696
  • [Journal Article] Comparison of HCV-associated gene expression and cell signaling pathways in cells with or without HCV replicon and in replicon-cured cells2010

    • Author(s)
      Nishimura-Sakurai Y, Sakamoto N, Kakinuma S, Azuma S, Watanabe M, et al.
    • Journal Title

      Journal of Gastroenterorlogy (印刷中(Epub ahead of print))

    • NAID

      10027216127

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590833
  • [Journal Article] Comparison of HCV-associated gene expression and cell signaling pathways in cells with or without HCV replicon and in replicon-cured cells2010

    • Author(s)
      Nishimura-Sakurai Y, Sakamoto N, Mogushi K, Nagaie S, Nakagawa M, Itsui Y, Sekine-Osajima Y, Tasaka-Fujita M, Onuki-Karakama Y, Suda G, Mishima M, Yamamoto M, Ueyama M, Funaoka Y, Watanabe T, Chen CH, Kakinuma S, Tsuchiya K, Tanaka H, Enomoto N, Watanabe
    • Journal Title

      J Gastroentorol

      Volume: 45 Pages: 523-36

    • NAID

      10027216127

    • Data Source
      KAKENHI-PROJECT-21590833
  • [Journal Article] Prevalence of metabolic syndrome is comparable between inflammatory bowel disease patients and the general population2010

    • Author(s)
      Nagahori M, Hyun SB, Totsuka T, Okamoto R, Kuwahara E, Takebayashi T, Naganuma M, Watanabe M
    • Journal Title

      J Gastroenterol

      Volume: 45 Pages: 1008-1013

    • DOI

      10.1007/s00535-010-0247-z

    • NAID

      10027699223

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590696
  • [Journal Article] IL-2 is positively involved in the development of co litogenic CD4+ IL-7R alpha high memory T cells in chronic colitis.2010

    • Author(s)
      Kameyama K, Totsuka T, Watanabe M, et al
    • Journal Title

      Eur J Immunol

      Volume: 183 Pages: 2423-2436

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590804
  • [Journal Article] Safety and usefulness of balloon endoscopy in Crohn's disease patients with postoperative ileal lesions.2010

    • Author(s)
      Naganuma M, Watanabe M, Hibi
    • Journal Title

      J Crohn' s Colitis

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590696
  • [Journal Article] Inhibition of hepatitis C virus replication by a specific inhibitor of serine-arginine-rich protein kinase2010

    • Author(s)
      Karakama Y, Sakamoto N, Itsui Y, Nakagawa M, Tasaka-Fujita M, Nishimura-Sakurai Y, Kakinuma S, Oooka M, Azuma S, Tsuchiya K, Onogi H, Hagiwara M, Watanabe M
    • Journal Title

      Antimicrob Agents Chemother

      Volume: 54 Pages: 3179-3186

    • Data Source
      KAKENHI-PROJECT-21390226
  • [Journal Article] Delta-like 1 expression promotes goblet cell differentiation in Notch-inactivated human colonic epithelial cells2010

    • Author(s)
      Akiyama J, Okamoto R, Iwasaki M, Zheng X, Yui S, Tsuchiya K, Nakamura T, and Watanabe M
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 393(4) Pages: 662-667

    • Data Source
      KAKENHI-PROJECT-21590803
  • [Journal Article] Longitudinal cell formation in the entire human small intestine is correlated with the localization of Hathl and Klf4.2010

    • Author(s)
      Iwasaki M, Tsuchiya K, Okamoto R, Okada E, Watanabe M
    • Journal Title

      J Gastroenterol

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590695
  • [Journal Article] Cell culture and in vivo analyses of cytopathic hepatitis C virus mutants2010

    • Author(s)
      Mishima K, Sakamoto N, Sekine-Osajima Y, Nakagawa M, Itsui Y, Azuma S, Kakinuma S, Kiyohashi K, Kitazume A, Tsuchiya K, Imamura M, Hiraga N, Chayama K, Wakita T, Watanabe M
    • Journal Title

      Virology

      Volume: 405 Pages: 361-369

    • Data Source
      KAKENHI-PROJECT-21590832
  • [Journal Article] IL-6-mediated intersubgenotypic variation of interferon sensitivity in hepatitis C virus genotype 2a/2b chimeric clones.2010

    • Author(s)
      Suda G, Sakamoto N, Azuma S, Kakinuma S, Watanabe M, et al.
    • Journal Title

      Virology

      Volume: 407 Pages: 80-90

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590833
  • [Journal Article] ITPA gene variant protects against anemia induced by pegylated interferon-alpha and ribavirin therapy for Japanese patients with chronic hepatitis C2010

    • Author(s)
      Sakamoto N, Tanaka Y, Nakagawa M, Yatsuhashi H, Nishiguchi S, Enomoto N, Azuma S, Nishimura-Sakurai Y, Kakinuma S, Nishida N, Tokunaga K, Honda M, Ito K, Mizokami M, Watanabe M
    • Journal Title

      Hepatol Res

      Volume: 40 Pages: 1063-1071

    • Data Source
      KAKENHI-PROJECT-21390226
  • [Journal Article] IL-2 is positively involved in the development of colitogenic CD4+ IL-7R alpha high memory T cells in chronic colitis.2010

    • Author(s)
      Kameyama K, Watanabe M, et al.
    • Journal Title

      Eur J Immunol.

      Volume: 40 Pages: 2423-2436

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-22117508
  • [Journal Article] MR enterocolonography is useful for simultaneous evaluation of small and large intestinal lesions in Crohn's disease.2010

    • Author(s)
      Hyun SB, Kitazume Y, Nagahori M, Akira T, Fujii T, Tsuchiya K, Suzuki S, Okada E, Araki A, Naganuma M, Watanabe M
    • Journal Title

      Inflam Bowel Dis

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590806
  • [Journal Article] Inhibition of HCV replication by a specific inhibitor of serin-arginine-rich protein kinase2010

    • Author(s)
      Karakama Y, Sakamoto N, Kakinuma S, Azuma S, Watanabe M, et al.
    • Journal Title

      Antimicrobial Agents and Chemotherapy

      Volume: 54 Pages: 3179-3186

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590833
  • [Journal Article] Magnetic resonance enterocolonography is u seful for simultaneous evaluation of small and large intestinal lesions in Crohn's disease.2010

    • Author(s)
      Hyun SB, Tsuchiya K, Okada E, Araki A, Watanabe M.
    • Journal Title

      Inflamm Bowel Dis.

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590694
  • [Journal Article] MR enterocolonography is useful for simultaneous evaluation of small and large intestinal lesions in Crohn's disease.2010

    • Author(s)
      Hyun SB, Kitazume Y, Nagahori M, Okada E, Watanabe M
    • Journal Title

      Inflam Bowel Dis

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590695
  • [Journal Article] Delta-like 1 expression promotes goblet cell differentiation in Notch-inactivated human colonic epithelial cells.2010

    • Author(s)
      Akiyama J, Nakamura T, Watanabe M, et al.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 393 Pages: 662-667

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229005
  • [Journal Article] Delta-like 1 expression promotes goblet cell differentiation in Notch-inactivated human colonic epithelial cells.2010

    • Author(s)
      Akiyama J, Watanabe M, et al.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 393 Pages: 662-667

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-22117508
  • [Journal Article] IL-2 is positively involved in the development of colitogenic CD4+ IL-7R alpha high memory T cells in chronic colitis.2010

    • Author(s)
      Kameyama K, Nemoto Y, Watanabe M, et al.
    • Journal Title

      Eur J Immunol. 40

      Pages: 2423-2436

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590736
  • [Journal Article] Delta-like 1 expression promotes goblet cell differentiation in Notch-inactivated human colonic epithelial cells2010

    • Author(s)
      Akiyama J, Okamoto R, Iwasaki M, Zheng X, Yui S, Tsuchiya K, Nakamura T, and Watanabe M
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 393(4) Pages: 662-667

    • Data Source
      KAKENHI-PROJECT-21590805
  • [Journal Article] Conception outcomes and opinions about pregnancy for men with inflammatory bowel disease.2010

    • Author(s)
      Sato A, Naganuma M, Watanabe ,M, et al.
    • Journal Title

      Journal and Crohn's and Colitis

      Volume: 4 Pages: 183-188

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590696
  • [Journal Article] IL-6-mediated intersubgenotypic variation of interferon sensitivity in hepatitis C virus genotype 2a/2b chimeric clones2010

    • Author(s)
      Suda G, Sakamoto N, Itsui Y, Nakagawa M, Tasaka-Fujita M, Funaoka Y, Watanabe T, Nitta S, Kiyohashi K, Azuma S, Kakinuma S, Tsuchiya K, Imamura M, Hiraga N, Chayama K, Watanabe M
    • Journal Title

      Virology

      Volume: 407 Pages: 80-90

    • Data Source
      KAKENHI-PROJECT-21390226
  • [Journal Article] Requirement of Notch activation duringregeneration of the intestinal epithelia2009

    • Author(s)
      Okamoto R, Tsuchiya K, Nemoto Y, AkiyamaJ, Nakamura T, Kanai T, Watanabe M
    • Journal Title

      Am JPhysiol GI & Liver 296

      Pages: 23-35

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590717
  • [Journal Article] Signaling pathway via TNFa/NFkB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis2009

    • Author(s)
      Onizawa M, Nagaishi T, Kanai T, Nagano KI, Oshima S, Nemoto Y, Yoshioka A, Totsuka T, Okamoto R, Nakamura T, Sakamoto N, TsuchiyaK, Aoki K, Ohya K, Yagita H and Watanabe M
    • Journal Title

      Am J Physol Gastrntest Liver Physiol (Epub ahead of print)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590752
  • [Journal Article] Signaling pathway via TNFα/NF κ B in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis.2009

    • Author(s)
      Onizawa M, Watanabe M, etal.
    • Journal Title

      Am J Physiol GI & Liver. (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590716
  • [Journal Article] Musashi-1 suppressesexpression of Paneth cell-specific genes inhuman intestinal epithelial cells2009

    • Author(s)
      Murayama M, Okamoto R, Tsuchiya K, Akiyama J, Nakamura T, Sakamoto N, Kanai T and Watanabe M
    • Journal Title

      Gasroenterology 44

      Pages: 173-82

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590752
  • [Journal Article] Signaling pathway via TNF-{alpha}/NF-{kappa} B in intestinalepithelial cells may be directly involved in colitis-associatedcarcinogenesis.2009

    • Author(s)
      Kanai T, Nemoto Y, Kamata M, Hisamatsu T, Watanabe M, Hibi T
    • Journal Title

      Curr Opin Gastroenterol in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390197
  • [Journal Article] Long-lived colitogenic CD4+ memory T cells residing outside the intestine participate in the perpetuation of chronic colitis.2009

    • Author(s)
      Nemoto Y, Kanai T, Watanabe M, et al.
    • Journal Title

      J Immunol. 183

      Pages: 5059-5068

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590736
  • [Journal Article] RANK-RANKL signaling pathway is critically involved in the function of CD4+CD25+ regulatory T Cells in chronic colitis2009

    • Author(s)
      Totsuka T, Kanai T, Nemoto Y, Tomita T, Okamoto R, Tsuchiya K, Nakamura T, Sakamoto N, Akiba H, Okumura K, Yagita H, Watanabe M
    • Journal Title

      J Immunol. 182

      Pages: 6079-6087

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19209027
  • [Journal Article] Two flavonoids extracts from Glycyrrhizae radix inhibit in vitro hepatitis C virus replication2009

    • Author(s)
      Sekine-Osajima Y, Sakamoto N, Nakagawa M, Itsui Y, Tasaka M, Nishimura-Sakurai Y, Chen CH, Suda G, Mishima K, Onuki Y, Yamamoto M, Maekawa S, Enomoto N, Kanai T, Tsuchiya K, Watanabe M
    • Journal Title

      Hepatol Res

      Volume: 39 Pages: 60-69

    • NAID

      10025324061

    • Data Source
      KAKENHI-PROJECT-21590832
  • [Journal Article] Long-Lived colitogenic CD4+ Memory T Cells residing outside the intestine participate in the perpetuation of chronic colitis.2009

    • Author(s)
      Nemoto Y, Watanabe M, et al.
    • Journal Title

      J Immunol. 183

      Pages: 5059-5068

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19209027
  • [Journal Article] Negative feedback regulation of colitogenic CD4+ T cells by increased granulopoiesis.2009

    • Author(s)
      Nemoto Y, Watanabe M, et al.
    • Journal Title

      Inflamm Bowel Dis. 14

      Pages: 1491-1503

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590716
  • [Journal Article] Signaling pathway via TNF-alpha/NF-kappaB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis2009

    • Author(s)
      Onizawa M, Nagaishi T, Kanai T, Nagano K, Oshima S, Nemoto Y, Yoshioka A, Totsuka T, Okamoto R, Nakamura T, Sakamoto N, Tsuchiya K, Aoki K, Ohya K, Yagita H, Watanabe M.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol 296

      Pages: 850-859

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390197
  • [Journal Article] Signaling pathway via TNF-{alpha}/NF-{kappa} B in intestinal epithelial cells may be directly involved in Colitis-associated carcinogenesis.2009

    • Author(s)
      Oni zawa M, Nagaishi T, Kanai T, Nagano K, 0shima S, Kemoto Y, Yoshi oka A, Totsuka T, Okamoto R, Nakamura T, Sakamoto N, Tsuchiya K, Aoki K, Ohya K, Yagita H, Watanabe M
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol. 296

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390197
  • [Journal Article] Signaling pathway via TNFα/NFκB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis.2009

    • Author(s)
      Onizawa M, Watanabe M, et al.
    • Journal Title

      Am J Physiol GI & Liver. (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19209027
  • [Journal Article] Signaling pathway via TNF-a/NF-kB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis2009

    • Author(s)
      Onizawa M, Nagaishi T, Kanai T, NaganoKI, Oshima S, Nemoto Y, Yoshioka A, TotsukaT, Okamoto R, Nakamura T, Sakamoto N, Tsuchiya K, Aoki K, Ohya K, Yagita H, Watanabe M
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol

      Volume: 296(4)

    • Data Source
      KAKENHI-PROJECT-21590805
  • [Journal Article] Two flavonoids extracts from Glycyrrhizae radix inhibit in vitro hepatitis C virus replication2009

    • Author(s)
      Sekine-Osajima Y, Sakamoto N, Nakagawa M, Itsui Y, Tasaka M, Nishimura-Sakurai Y, Chen CH, Suda G, Mishima K, Onuki Y, Yamamoto M, Maekawa S, Enomoto N, Kanai T, Tsuchiya K, Watanabe M
    • Journal Title

      Hepatol Res

      Volume: 39 Pages: 60-69

    • NAID

      10025324061

    • Data Source
      KAKENHI-PROJECT-21390226
  • [Journal Article] ヒスチジン栄養療法はマクロファージの炎症性サイトカイン産生を抑制して腸炎モデルを改善させる2009

    • Author(s)
      永石宇司、渡辺守
    • Journal Title

      Review of Gastroenterology & Clinical Gastro-enterology and Hepatology

      Volume: 4(2) Pages: 42-45

    • Data Source
      KAKENHI-PROJECT-21590806
  • [Journal Article] Long-Lived colitogenic CD4+ Memory T Cells residing outside the intestine participate in the perpetuation of chronic colitis2009

    • Author(s)
      Nemoto Y, Kanai T, Kameyama K, Shinohara T, Sakamoto N, Totsuka T, Okamoto R, Tsuchiya K, Nakamura T, Sudo T, Matsumoto S, Watanabe M
    • Journal Title

      J Immunol. 183

      Pages: 5059-5068

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19209027
  • [Journal Article] IL-7 is essential for lymphopenia-driven turnover of colitogenic CD4+ memory T cells in chronic colitis.2009

    • Author(s)
      Tomita T, Nemoto Y, Watanabe M, et al.
    • Journal Title

      Eur J Immunol. 39

      Pages: 2737-2747

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590736
  • [Journal Article] Requirement of Notch activation during regeneration of the intestinal epithelia2009

    • Author(s)
      Okamoto R, Tsuchiya K, Nemoto Y, Akiyama J, Nakamura T, Kanai T, Watanabe M
    • Journal Title

      Am J Physiol GI & Liver 296

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19209027
  • [Journal Article]2009

    • Author(s)
      長堀正和、渡辺守
    • Journal Title

      【炎症性腸疾患 診断と治療の進歩】潰瘍性大腸炎の管理・治療 潰瘍性大腸炎の内科治療(解説/特集)日本内科学会雑誌 98巻(日本内科学会)

      Pages: 54-60

    • Data Source
      KAKENHI-PROJECT-21590806
  • [Journal Article]2009

    • Author(s)
      戸塚輝治、渡辺守
    • Journal Title

      炎症と免疫(Vol.17 no.3)サイトカインと炎症性疾患・自己免疫疾患 その病態における役割と治療展開 炎症性腸疾患(解説)(先端医学社)

      Pages: 327-334

    • Data Source
      KAKENHI-PROJECT-21590804
  • [Journal Article] Antiviral effects of the interferon-induced protein guanylate binding protein 1 and its interaction with the hepatitis C virus NS5B protein2009

    • Author(s)
      Itsui Y, Sakamoto N, Kakinuma S, Nakagawa M, Sekine-Osajima Y, Tasaka-Fujita M, Nishimura-Sakurai Y, Suda G, Karakama Y, Mishima K, Yamamoto M, Watanabe T, Ueyama M, Funaoka Y, Azuma S, Watanabe M
    • Journal Title

      Hepatology

      Volume: 50 Pages: 1727-1737

    • Data Source
      KAKENHI-PROJECT-21390226
  • [Journal Article] Requirement of Notch activation during regeneration of the intestinal epithelia2009

    • Author(s)
      Okamoto R, Tsuchiya K, Nemoto Y, Akiyama J, Nakamura T, Kanai T, Watanabe M.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol 296

      Pages: 23-35

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390197
  • [Journal Article] IL-7 is essential for lymphopenia-driven turnover of colitogenic CD4+ memory T cells in chronic colitis.2009

    • Author(s)
      Tomita T, Watanabe M, et al.
    • Journal Title

      Eur J Immunol. 39

      Pages: 2737-2747

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19209027
  • [Journal Article] RANKL2009

    • Author(s)
      Totsuka T, Kanai T, Watanabe M.
    • Journal Title

      J Immunol in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390197
  • [Journal Article] Persistent retention of Colitogenic CD4(+)memory T cells causes inflammatory bowel diseases to become intractable.2009

    • Author(s)
      kanai T, Nemoto Y, Tomita T, Totsuka T, Watanabe M, Hibi T.
    • Journal Title

      Inflamm Bowel Dis in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390197
  • [Journal Article] Requirement of Notch activation during regeneration of the intestinal epithelia2009

    • Author(s)
      Okamoto R, Tsuchiya K, Nemoto Y, Akiyama J, Nakamura T, Kanai T, Watanabe M
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol

      Volume: 296(1) Pages: 23-35

    • Data Source
      KAKENHI-PROJECT-21590803
  • [Journal Article] Requirement of Notch activation during regeneration of the intestinal epithelia.2009

    • Author(s)
      Okamoto R, Tsuchiya K, Nemoto Y, Akiyama J, Nakamura T, Kanai T, Watanabe M
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol

      Volume: 296(1)

    • Data Source
      KAKENHI-PROJECT-21590805
  • [Journal Article] Single-operator double-balloon endoscopy (DBE) is as effective as dual-operator DBE2009

    • Author(s)
      Araki A, Tsuchiya K, Okada E, Suzuki S, Oshima S, Yoshioka S, Yoshioka A, Kanai T, Watanabe M.
    • Journal Title

      J Gastroenterol Hepatol(Epub ahead of print)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390197
  • [Journal Article] Single-operator double-balloon endoscopy (DBE)is as effectiveas dual-operator DBE.2009

    • Author(s)
      Araki A, Tsuchiya K, Okada E, Suzuki S, Oshima S, Yoshioka S, Yoshioka A, Kanai T, Watanabe M.
    • Journal Title

      J Gastroenterol Hepatol. in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390197
  • [Journal Article] Requirement of Notch activation during regeneration of the intestinal epithelia.2009

    • Author(s)
      Okamoto R, Tsuchiya K, Nemoto Y, Akiyama J, Nakainura T, Kanai T, Watanabe M.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol. 296

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390197
  • [Journal Article] Musashi-1 suppresses expression of Paneth cell specific genes in human intestinal epithelial cells.2009

    • Author(s)
      Murayama M, Watanabe M, et al.
    • Journal Title

      J Gastroenterol. 44

      Pages: 173-182

    • NAID

      10025173646

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19209027
  • [Journal Article] Two flavonoids extracts from a herb, Glycyrrhizae radix, inhibit in-vitro hepatitis C virus replication2009

    • Author(s)
      Sekine-Osajima Y, Sakamoto N, Nakagawa M, Itsui Y, Tasaka M, Nishimura-Sakurai Y, Chen CH, Suda G, Mishima K, Onuki Y, Yamamoto M, Maekawa S, Enomoto N, Kanai T, Tsuchiya K, Watanabe M
    • Journal Title

      Hepatology Res 39(1)

      Pages: 60-69

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390196
  • [Journal Article]2009

    • Author(s)
      戸塚輝治、金井隆典、渡辺守
    • Journal Title

      消化器と免疫 45号消化器疾患における自然免疫・獲得免疫のクロストーク 慢性大腸炎の発症と維持におけるIL-7の役割(日本消化器免疫学会)

      Pages: 47-51

    • Data Source
      KAKENHI-PROJECT-21590804
  • [Journal Article] Two flavonoids extracts from a herb, Glycyrrhizae radix, inhibit in-vitro hepatitis C virus replication.2009

    • Author(s)
      Sekine-Osajima Y, Sakamoto N, Nakagawa M, Itsui Y, Tasaka M, Nishimura-Sakurai Y, Chen CH, Suda G, Mishima K, Onuki Y, Yamamoto M, Maekawa S, Enomoto N, Kanai T, Tsuchiya K, Watanabe M
    • Journal Title

      Hepatoloj Res 39

      Pages: 60-69

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390196
  • [Journal Article] New therapeutic approaches to HCV.J2009

    • Author(s)
      Naoya Sakamoto, Mamoru Watanabe
    • Journal Title

      Gastroenterol (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390196
  • [Journal Article] Persistent retention of colitogenic CD4+ memory T cells causes inflammatory bowel diseases to become intractable.2009

    • Author(s)
      Kanai T, Nemoto Y, Watanabe M, et al.
    • Journal Title

      Inflamm Bowel Dis. 15(Review)

      Pages: 926-934

    • Data Source
      KAKENHI-PROJECT-20590736
  • [Journal Article] ヒスチジン栄養療法はマクロファージの炎症性サイトカイン産生を抑制して腸炎モデルを改善させる2009

    • Author(s)
      永石宇司、渡辺守
    • Journal Title

      Review of Gastroenterology & ClinicalGastroenterology and Hepatology 4(2)

      Pages: 42-45

    • Data Source
      KAKENHI-PROJECT-20590737
  • [Journal Article] Two flavonoidsextracts from Glycyrrhizae radix inhibit in vitrohepatitis C virus replication2009

    • Author(s)
      Sekine-Osajima Y, Sakamoto N, Nakagawa M, Itsui Y, Tasaka M, Nishimura-Sakurai Y, Chen CH, Suda G, Mishima K, Onuki Y, Yamamoto M, Maekawa S, Enomoto N, Kanai T, Tsuchiya K and Watanabe M
    • Journal Title

      Hepatol Res 39

      Pages: 60-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590752
  • [Journal Article] Requirement of Notch activation during regeneration of the intestinal epithelia.2009

    • Author(s)
      Okamoto R, Watanabe M, etal.
    • Journal Title

      Am J Physiol GI & Liver. 296

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590716
  • [Journal Article] Musashi-1 suppresses expression of Paneth cell-specific genes in human intestinal epithelial cells2009

    • Author(s)
      Murayama M, Okamoto R, Tsuchiya K, Akiyama J, Nakamura T, Sakamoto N, Kanai T, Watanabe M.
    • Journal Title

      J Gastroenterol 44

      Pages: 173-182

    • NAID

      10025173646

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390197
  • [Journal Article] Musashi-l suppresses expression of Paneth cell-specific genes inhuman intestinal epithelial cells.2009

    • Author(s)
      Murayama M, Okamoto R, Tsuchi ya K, Akiyama J, Nakamura T, Sakamoto N, Kanai T, Watanabe M.
    • Journal Title

      J Gastroenterol. 44

      Pages: 173-182

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390197
  • [Journal Article] Signaling pathway via TNF-a/NF-kB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis2009

    • Author(s)
      Onizawa M, Nagaishi T, Kanai T, Nagano KI, Oshima S, Nemoto Y, Yoshioka A, Totsuka T, Okamoto R, Nakamura T, Sakamoto N, Tsuchiya K, Aoki K, Ohya K, Yagita H, Watanabe M
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol

      Volume: 296(4) Pages: 850-859

    • Data Source
      KAKENHI-PROJECT-21590803
  • [Journal Article] New therapeutic approaches to hepatitis C virus.2009

    • Author(s)
      Sakamoto N, Watanabe M.
    • Journal Title

      J Gastroenterol. 44

      Pages: 643-649

    • NAID

      10025175879

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226
  • [Journal Article] FTY720 suppresses the development of colitis in lymphoid-null mice by modulating the trafficking of colitogenic CD4+ T cellsin bone marrow2009

    • Author(s)
      Fujii T, Kanai T, Tomita T, Nemoto Y,Totsuka T, Sakamoto N, Nakamura T,Tsuchiya K, Okamoto R, Watanabe M
    • Journal Title

      Eur J Immunol 38(12)

      Pages: 3290-3303

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390196
  • [Journal Article] Signaling pathway via TNFα/NFκB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis.2009

    • Author(s)
      Onizawa M, Watanabe M, et al.
    • Journal Title

      Am J Physiol GI & Liver. 296

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19209027
  • [Journal Article] Requirement of Notch activation during regeneration of the intestinal epithelia.2009

    • Author(s)
      Okamoto R, Watanabe M, et al.
    • Journal Title

      Am J Physiol GI & Liver. 296

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19209027
  • [Journal Article] Antiviral effects of the interferon-induced protein GBP-1 and its interaction with the hepatitis C virus NS5B protein2009

    • Author(s)
      Itsui Y, Sakamoto N, Kakinuma S, Nakagawa M, Sekine-Osajima Y, Tasaka-Fujita M, Nishimura-Sakurai Y, Suda G, Karakama Y, Mishima K, Yamamoto M, Watanabe T, Ueyama M, Funaoka Y, Azuma S, Watanabe M
    • Journal Title

      Hepatology

      Volume: 50 Pages: 1727-37

    • Data Source
      KAKENHI-PROJECT-21590833
  • [Journal Article] Signaling pathway via TNFa/NFnB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis.2009

    • Author(s)
      Onizawa, Kanai T, Totsuka T, Okamoto R, Tsuchiya K, Nemoto Y, Nagaishi T, Sakamoto N, Watanabe M
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol In press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390196
  • [Journal Article] Hepatic stem/progenitor cells and stem-cell transplantation for the treatment of liver disease2009

    • Author(s)
      Kakinuma S, Nakauchi H and Watanabe M
    • Journal Title

      J Gasroenterology 44

      Pages: 167-72

    • NAID

      10025173601

    • Data Source
      KAKENHI-PROJECT-19590752
  • [Journal Article] Homeostatic (IL-7) and effector (IL-17) cytokines as distinct but complementary target for an optimal therapeutic strategy in inflammatory bowel disease2009

    • Author(s)
      Kanai T, Nemoto Y, Kamada N, Totsuka T, Hisamatsu T, Watanabe M, Hibi T.
    • Journal Title

      Curr Opin GastroenterolEpub ahead of print(Curr Opin Gastroenterol)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390197
  • [Journal Article]2009

    • Author(s)
      永石宇司、渡辺守
    • Journal Title

      Review of Gastroenterology & Clinical Gastroenterology and Hepatology(ヒスチジン栄養療法はマクロファージの炎症性サイトカイン産生を抑制して腸炎モデルを改善させる)

      Pages: 42-45

    • Data Source
      KAKENHI-PROJECT-20590737
  • [Journal Article] Signaling pathway via TNF/NF B in intestinal epithelial cell smay be directly involved in colitis associatedcarcinogenesis2009

    • Author(s)
      Nagaishi T, Onizawa M Okamoto R, Watanabe M, et al
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol

      Volume: 296

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590806
  • [Journal Article] Requirement of Notch activation duringregeneration of the intestinal epithelia2009

    • Author(s)
      Okamoto R, Tsuchiya K, Nemoto Y, AkiyamaJ, Nakamura T, Kanai T, Watanabe M
    • Journal Title

      Am Jphysiol GI & Liver 296

      Pages: 23-35

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590716
  • [Journal Article] Negative feedback regulation of colitogenic CD4+ T cells by increased granulopolesis.2009

    • Author(s)
      Nemoto Y, Watanabe M, et al.
    • Journal Title

      Inflamm Bowel Dis. 14

      Pages: 1491-1503

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19209027
  • [Journal Article] RANK-RANKL signaling pathway is critically involved in the function of CD4+CD25+ regulatory T cells in chronic colitis2009

    • Author(s)
      Totsuka T, Kanai T, Nemoto Y, Tomita T, Okamoto R, Tsuchiya K, Nakamura T, Sakamoto N, Akiba H, Okumura K, Yagita H, Watanabe M.
    • Journal Title

      J Immunol 182

      Pages: 6079-6087

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390197
  • [Journal Article] Antiviral effects of the interferon-induced protein GBP-1 and its interaction with the hepatitis C virus NS5B protein.2009

    • Author(s)
      Itsui Y, Sakamoto N, Kakinuma S, Azuma S, Watanabe M, et al.
    • Journal Title

      Hepatology 50

      Pages: 1727-37

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590833
  • [Journal Article] New therapeutic approaches to hepatitis Cvirus2009

    • Author(s)
      Sakamoto N, Watanabe M
    • Journal Title

      JGastroenterol

      Volume: 44 Pages: 643-649

    • NAID

      10025175879

    • Data Source
      KAKENHI-PROJECT-21390226
  • [Journal Article] RANK-RANKL signaling pathway is critically involved in the function of CD4+CD25+ regulatory T Cells in chronic colitis.2009

    • Author(s)
      Totsuka T, Watanabe M, et al.
    • Journal Title

      J Immunol. 182

      Pages: 6079-3087

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19209027
  • [Journal Article] Persistent retention of colitogenic CD4+ memory T cells causes inflammatory bowel diseases to become intractable2009

    • Author(s)
      Kanai T, Nemoto Y, Tomita T, Totsuka T, Watanabe M, Hibi T.
    • Journal Title

      Inflamm Bowel Dis. 15

      Pages: 926-934

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390197
  • [Journal Article] Immunosenescent colitogenic CD4+ T cells convert to regulatory cells to suppress colitis.2008

    • Author(s)
      Totsuka T, Watanabe M, et al.
    • Journal Title

      Eur J Immunol. 38

      Pages: 1275-1286

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590716
  • [Journal Article] Proteasomal degradalion of Atohl by aberrant Wnt signaling maintains the undifferentiated state of colon cancer.2008

    • Author(s)
      Aragnki M, Tsuchiya K, Okamoto R, Yoshioka S. Nakamura T, Sakamoto N, Kanai T, Watanabe M.
    • Journal Title

      Biochem Biophys Res Commun 368

      Pages: 923-929

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390197
  • [Journal Article] Immunosenescent colitogenic CD4+ T cells convert to regulatory cells and suppress colitis.2008

    • Author(s)
      Totsuka T, Watanabe M, et al.
    • Journal Title

      Eur J Immunol. 38

      Pages: 1275-1286

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590736
  • [Journal Article] Colitogenic CD4^+ effector-memory T cells actively recirculate in chronic colltic mice.2008

    • Author(s)
      Tomita T, Watanabe M, et al.
    • Journal Title

      Inflamm Bowel Dis. 14

      Pages: 1630-1640

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590716
  • [Journal Article] MyD88-dependent pathway in T cells directly modulates the expansion and survival of colitogenic CD4+ T cells in chronic colitis2008

    • Author(s)
      Tomita T, Kanai T, Fujii T, Nemoto Y, Okamoto R, Tsuchiya K, Totsuka T, SakamotoN, Akira S, Watanabe M
    • Journal Title

      J Immunol 180

      Pages: 5291-5299

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590717
  • [Journal Article] Systemic, but not intestinal, IL-7is essential for the persistence of chronic colitis2008

    • Author(s)
      Tomita T, Kanai T, Nemoto Y, Totsuka T, Okamoto R, Tsuchiya K, Sakamoto N and Watanabe M
    • Journal Title

      J Immunol 180

      Pages: 383-90

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590752
  • [Journal Article] Proteasomal degradation of Atoh1 by aberrant Wnt signaling maintains the undifferentiated state of colon cancer2008

    • Author(s)
      Aragaki M, Tsuchiya K, Okamoto R, Yoshioka S, Nakamura T, Sakamoto N, Kanai T, Watanabe M.
    • Journal Title

      Biochem Biophys Res Commun 368

      Pages: 923-929

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390197
  • [Journal Article] Immunosenescent colitogenic CD4+ T cells convert to regulatory cells and suppress colitis.2008

    • Author(s)
      Totsuka T, Kanai T, Nemoto Y, Tomita T, Tsuchiya K, Sakamoto N, Okamoto R, Watanabe M
    • Journal Title

      Eur J Immunol 38

      Pages: 1275-1286

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390196
  • [Journal Article] MyD88-dependent pathway in T cells directly modulates the expansion of colitogenic CD4+ T cells in chronic colitis.2008

    • Author(s)
      Tomita T, Nemoto Y, Watanabe M, et al.
    • Journal Title

      J Immunol. 180

      Pages: 5291-5299

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590736
  • [Journal Article] FTY720 suppresses the development of colitis in lymphoid-null mice by modulating the trafficking of colitogenic CD4+ T cells in bone marrow.2008

    • Author(s)
      Fujii T, Nemoto Y, Watanabe M, et al.
    • Journal Title

      Eur J Immunol 38

      Pages: 3290-3303

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590736
  • [Journal Article] Development of plaque assaysfor hepatitis C virus and isolation of mutantswith enhanced cytopathogenicity and replication capacity2008

    • Author(s)
      Sekine-Osajima Y, Sakamoto N(equal contribution), Nakagawa M, Itsui Y, TasakaM, Nishimura-Sakurai Y, Chen CH, Kanai T,Tsuchiya K, Wakita T, Enomoto N and Watanabe M
    • Journal Title

      Virology 371

      Pages: 71-85

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390196
  • [Journal Article] Negative feedback regulation of colitogenic CD4(+)T cells by increased granulopoiesis.2008

    • Author(s)
      Nemoto Y, Kanai T, Tohda S, Totsuka T, Okamoto R, Tsuchiya K, Nakamura T, Sakamoto N, Fukuda T, Miura O, Yagita H, Watanabe M
    • Journal Title

      Inflamm Bowel Dis 14(11)

      Pages: 1491-1503

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590718
  • [Journal Article] Negative feedback regulation of colitogenic CD4+ T cells by increased granulopoiesis2008

    • Author(s)
      Nemoto Y, Kanai T, Tohda S, Totsuka T, Okamoto R, Tsuchiya K, Nakamura T, Sakamoto N, Fukuda T, Miura O, Yagita H, Watanabe M
    • Journal Title

      Inflamm Bowel Dis. 14

      Pages: 1491-1503

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390197