OOOKA Shinya 大岡真也

Researcher Number	90361691
Affiliation (based on the past Project Information) *help	2016: 東京医科歯科大学, 医歯(薬)学総合研究科, 准教授 2013 – 2014: 東京医科歯科大学, 医歯(薬)学総合研究科, 特任准教授 2009 – 2012: Tokyo Medical and Dental University, 医学部附属病院, 講師 2011: 東京医科歯科大学, 医学部・附属病院, 講師 2007: 医科歯科大, 医学部附属病院, 助手 2004 – 2006: 東京医科歯科大学, 医学部附属病院, 助手
Review Section/Research Field	Principal Investigator Gastroenterology Except Principal Investigator Gastroenterology
Keywords	Principal Investigator HCVレプリコン / B型肝炎ウイルス / Ｂ型肝炎ウイルス / 肝細胞癌 / 肝臓病学 / cyclophilin / HCV replicon system / Cyclosporin A / small interfering RNA / サイクロフィリン … More / レトロウイルスベクター / 抗ウイルス療法 / サイクロスポリンA / レプリコン・システム / C型肝炎ウイルス / IL-6 / IFNλ / Cardif / HCV / ＩＬ28Ｂ / ＮＳ4Ｂ / インターフェロン / ＨＣＶ / RNAポリメラーゼ / 小胞体ストレス / ヒト肝臓キメラマウス / 細胞障害効果 / プラークアッセイ / HCV-JFH1培養系 / 遺伝子導入療法 / siRNA … More Except Principal Investigator 炎症性腸疾患 / leukocytapheresis / Crohn's disease / ulcerative colitis / inflammatory bowel disease / CD16 / TNFα / 単球・マクロファージ / 白血球除去療法 / 幹細胞 / 腸 / 末梢血 / 炎症性 / マウス慢性大腸炎モデル / ミラクルビーズ / ペプチド / 腸内細菌 Less

ウイルス性肝炎関連肝発癌における遺伝子変異と遺伝子発現制御機構の解析Principal Investigator
- Principal Investigator
  
  大岡真也
- Project Period (FY)
  2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
Impaired host response and HCV disturbance of type I/III IFN signaling are closely associated with non-response to IFN-based anti-HCV treatmentPrincipal Investigator
- Principal Investigator
  
  OOKA Shinya
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
Development of plaque assay to isolate cytopathic HCV clonesPrincipal Investigator
- Principal Investigator
  
  OOOKA Shinya
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
C型肝炎ウイルス発現モデル動物を用いたsiRNAによる感染抑制系の開発Principal Investigator
- Principal Investigator
  
  大岡真也
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
腸内細菌フローラ由来菌体成分に対する新しい生体側受容体の単離
- Principal Investigator
  
  宮田達也
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
The development of 2nd generated leukocytapheresis to remove phathological immune cells in inflammatory bowel diseases
- Principal Investigator
  
  ARAKI Akihiro
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
Suppression of hepatitis C virus replication by cyclosporine APrincipal Investigator
- Principal Investigator
  
  OOOKA Shinya
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University

All 2016 2011 2010 2005 2004

All Journal Article Presentation

[Journal Article] The inhibitory effect on hepatitis C virus infection of a triterpenoid compound, with or without interferon-alpha2011
- Author(s)
  Watanabe T, Sakamoto N, Nakagawa M, Kakinuma S, Itsui Y, Nishimura-Sakurai Y, Ueyama M, Funaoka Y, Kitazume A, Nitta S, Kiyohashi K, Murakawa M, Azuma S, Tsuchiya K, Oooka S, Watanabe M
- Journal Title
  
  Antimicrob Agents Chemother
  
  Volume: 55(6) Pages: 2537-2545
- Data Source
  KAKENHI-PROJECT-21590832
[Journal Article] Inhibitory effect of a triterpenoid compound, with or without alpha interferon, on hepatitis C virus infection2011
- Author(s)
  Watanabe T, Sakamoto N, Nakagawa M, Azuma S, Watanabe M, et al.
- Journal Title
  
  Antimicrob Agents Chemother
  
  Volume: 55(6) Issue: 6 Pages: 2537-2545
- DOI
  10.1128/aac.01780-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390226, KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-21590832, KAKENHI-PROJECT-22659145, KAKENHI-PROJECT-22790633, KAKENHI-PUBLICLY-23130506, KAKENHI-PROJECT-23790778
[Journal Article] SR蛋白リン酸化酵素阻害剤によるHCV増殖抑制効果の解析2010
- Author(s)
  唐鎌優子、坂本直哉、井津井康浩、中川美奈、藤田めぐみ、櫻井幸、柿沼晴、大岡真也、東正新、土屋輝一郎、小野木博、萩原正敏、渡辺守
- Journal Title
  
  消化器内科
  
  Volume: 51(6) Pages: 632-635
- Data Source
  KAKENHI-PROJECT-21590832
[Journal Article] Inhibition of HCV replication by a specific inhibitor of serin-arginine-rich protein kinase.2010
- Author(s)
  Yuko Karakama, Naoya Sakamoto, Shinva Oooka, et al.
- Journal Title
  
  Antimicrobial Agent and Chemotherapy
  
  Volume: 54 Pages: 3179-31869
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590832
[Journal Article] Suppression of hepatitis C virus replication by cyclosporin A is mediated by blockade of cyclophilins2005
- Author(s)
  Nakagawa M, Oooka S, et al.
- Journal Title
  
  Gastroenterology 129
  
  Pages: 1031-1041
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590580
[Journal Article] Suppression of hepatitis C virus replication by cyclosporin A is mediated by blockade of cyclophilins.2005
- Author(s)
  Nakagawa M, Sakamoto N, Tanabe Y, Koyama T, Itsui Y, Takeda Y, Chen CH, Kakinuma S, Oooka S, Maekawa S, Enomoto N, Watanabe M
- Journal Title
  
  Gastroenterology 129(3)
  
  Pages: 1031-1041
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590580
[Journal Article] Specific inhibition of hepatitis C virus replication by cyclosporin A2004
- Author(s)
  Sakamoto N., Oooka M, et al.
- Journal Title
  
  Biochem Biophys Res Com 313
  
  Pages: 42-47
- Data Source
  KAKENHI-PROJECT-16590580
[Presentation] Dose-reduction gemcitabine and S1 combination therapy in over 70 years old patients with unresectable pancreatic cancer2016
- Author(s)
  Ooka S, Dan N, Noguchi O, Nouchi T, Sakai Y, Kawamura T, Sakashita H, Tomita M, Miyake S, Watanabe M.
- Organizer
  第16回日本臨床腫瘍学会学術集会
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Data Source
  KAKENHI-PROJECT-16K09345

1. WATANABE Mamoru (10175127)

# of Collaborated Projects: 6 results

# of Collaborated Products: 5 results
2. SAKAMOTO Naoya (10334418)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
3. NAKAGAWA Mina (30401342)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. ASAHINA Yasuhiro (00422692)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 井津井康浩 (20401341)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. AZUMA Seishin (10376783)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. ENOMOTO Nobuyuki (20251530)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. ARAKI Akihiro (80361690)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KANAI Takanori (40245478)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 宮田達也 (50262192)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 半田宏 (80107432)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 柿沼晴 (30372444)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. CHEN Cheng-hsin

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

OOOKA Shinya 大岡 真也

Research Projects

Research Products

Co-Researchers

ウイルス性肝炎関連肝発癌における遺伝子変異と遺伝子発現制御機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Impaired host response and HCV disturbance of type I/III IFN signaling are closely associated with non-response to IFN-based anti-HCV treatmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of plaque assay to isolate cytopathic HCV clonesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

C型肝炎ウイルス発現モデル動物を用いたsiRNAによる感染抑制系の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

腸内細菌フローラ由来菌体成分に対する新しい生体側受容体の単離

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The development of 2nd generated leukocytapheresis to remove phathological immune cells in inflammatory bowel diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Suppression of hepatitis C virus replication by cyclosporine APrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The inhibitory effect on hepatitis C virus infection of a triterpenoid compound, with or without interferon-alpha2011

Author(s)

Journal Title

Data Source

[Journal Article] Inhibitory effect of a triterpenoid compound, with or without alpha interferon, on hepatitis C virus infection2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] SR蛋白リン酸化酵素阻害剤によるHCV増殖抑制効果の解析2010

Author(s)

Journal Title

Data Source

[Journal Article] Inhibition of HCV replication by a specific inhibitor of serin-arginine-rich protein kinase.2010

Author(s)

Journal Title

Data Source

[Journal Article] Suppression of hepatitis C virus replication by cyclosporin A is mediated by blockade of cyclophilins2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Suppression of hepatitis C virus replication by cyclosporin A is mediated by blockade of cyclophilins.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Specific inhibition of hepatitis C virus replication by cyclosporin A2004

Author(s)

Journal Title

Data Source

[Presentation] Dose-reduction gemcitabine and S1 combination therapy in over 70 years old patients with unresectable pancreatic cancer2016

Author(s)

Organizer

OOOKA Shinya 大岡真也