AZUMA SEISHIN 東正新

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AZUMA Seishin 東正新

陳正新

東正新(陳正新) アヅマセイシン

CHEN Cheng-Hsin 陳正新

CHEN Cheng-hsin 陳正新

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Researcher Number	10376783
Other IDs
Affiliation (Current)	2025: 地方独立行政法人東京都立病院機構東京都立墨東病院(臨床研究支援室臨床研究部), 消化器内科, 部長
Affiliation (based on the past Project Information) *help	2018 – 2021: 東京医科歯科大学, 大学院医歯学総合研究科, 寄附講座准教授 2015 – 2017: 東京医科歯科大学, 医学部附属病院, 講師 2007 – 2014: Tokyo Medical and Dental University, 医学部附属病院, 助教 2012: 東京医科歯科大学, 医学部附属病院, 講師 2011: 東京医科歯科大学, 医学部・附属病院, 助教 2006: Tokyo Medical and Dental University, Department of Gastroenerology and Hepatology, Instructor, 大学院医歯学総合研究科, 助手 2005: 東京医科歯科大学, 大学院・医歯学総合研究科, 助手
Review Section/Research Field	Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related Except Principal Investigator Gastroenterology
Keywords	Principal Investigator 発生・分化 / 再生医学 / 幹細胞 / 肝細胞 / iPS細胞 / 肝前駆細胞 / ヒトiPS細胞 / 肝星細胞 / 肝疾患治療 / 細胞移植 … More / 線維化 / 胆汁うっ滞性肝障害 / 肝硬変 / 肝線維化 / 分化 / 間葉系細胞 / 肝幹/前駆細胞 / 胆管細胞 / 細胞間相互作用 / シグナル調節 / Hepatocytes / Cell biology / Cell therapy / Umbilical cord blood / Stem cells / Transplantation / Development ＆ Differentiation / Regenerative medicine / 傷害肝 / 再生医療 / 細胞生物学 / 臍帯血 / 移植・再生医療 / 細胞・組織 / 移植 / CD13 / 肝細胞移植 / 肝臓学 / shRNA / FACS / C型肝炎ウイルス / 肝幹細胞 … More Except Principal Investigator HCV-JFH1培養系 / HCVレプリコン / RNAポリメラーゼ / 小胞体ストレス / ヒト肝臓キメラマウス / 細胞障害効果 / プラークアッセイ / 生体発光共鳴エネルギー転移(Bioliminescence Resonance Energy ransfer) / Cardif / STING / HCV-NS4B / RIG-I / インターフェロン / HCV レプリコン / 小分子ライブラリー / HCV-Feoレプリコン / レプリコンシステム / C型肝炎 / HVC-JFH1培養系 Less

肝星細胞におけるTNFシグナルを基軸とした肝線維化分子機構の解明Principal Investigator
- Principal Investigator
  
  東正新 (陳正新)
- Project Period (FY)
  2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokyo Medical and Dental University
Analysis of cell-to-cell interaction between hepatic progenitor cells and hepatic mesenchymal cells and a search of target molecules for a therapy of liver fibrosisPrincipal Investigator
- Principal Investigator
  
  AZUMA Seishin
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokyo Medical and Dental University
Research on molecular mechanisms underlying terminal differentiation of hepatic stem/progenitor cells via non-canonical Wnt signaling pathwaysPrincipal Investigator
- Principal Investigator
  
  AZUMA Seishin
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
Study on establishment of experimental animal model for chimeric liver with hepatitis C virus infection using induced hepatocyte-like cellsPrincipal Investigator
- Principal Investigator
  
  AZUMA Seishin
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
High-throughput screening of virus-and host-targeted suppressors of HCV infection
- Principal Investigator
  
  SAKAMOTO Naoya
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
FRET/ BRET analysis of interaction between HCV protein and interferon signaling
- Principal Investigator
  
  FUJITA Megumi (TASAKA Megumi)
- Project Period (FY)
  2009 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
Development of plaque assay to isolate cytopathic HCV clones
- Principal Investigator
  
  OOOKA Shinya
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
Analysis on molecular mechanisms of liver reconstitution by transplanted hepatic cellsPrincipal Investigator
- Principal Investigator
  
  AZUMA Seishin (CHEN Cheng-Hsin)
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
Search for new classes of HCV therapeutics by large scale screening of antiviral compounds and host cellular factors
- Principal Investigator
  
  SAKAMOTO Naoya
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
Research on transplantation of hepatic stem cells and development of experimental mouse models for hepatitis C virusPrincipal Investigator
- Principal Investigator
  
  CHEN Cheng-hsin
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
Study on hepatic differentiation of mesenchymal stem cells derived from human umbilical cord blood, and cell therapy for liver disease by use of mesenchymal stem cells.Principal Investigator
- Principal Investigator
  
  CHEN Cheng-Hsin
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University

[Journal Article] Time course alterations of virus sequences and immunoglobulin titers in a chronic hepatitis E patient2020
- Author(s)
  Nitta Sayuri、Takahashi Kazuaki、Kawai‐Kitahata Fukiko、Tsuchiya Jun、Sato Ayako、Miyoshi Masato、Murakawa Miyako、Itsui Yasuhiro、Nakagawa Mina、Azuma Seishin、Kakinuma Sei、Watanabe Mamoru、Asahina Yasuhiro
- Journal Title
  
  Hepatology Research
  
  Volume: 50 Issue: 4 Pages: 524-531
- DOI
  10.1111/hepr.13480
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09407, KAKENHI-PROJECT-17K19647, KAKENHI-PROJECT-19K08415, KAKENHI-PROJECT-19K08461, KAKENHI-PROJECT-20K08303, KAKENHI-PROJECT-18H02790, KAKENHI-PROJECT-19H03635, KAKENHI-PROJECT-18K07964, KAKENHI-PROJECT-19K17453
[Journal Article] Mac-2 binding protein glycosylation isomer as a novel predictive biomarker for patient survival after hepatitis C virus eradication by DAAs2020
- Author(s)
  Nakagawa M, Nawa N, Takeichi E, Shimizu T, Tsuchiya J, Sato A, Miyoshi M, Kawai-Kitahata F, Murakawa M, Nitta S, Itsui Y, Azuma S, Kakinuma S, Fujiwara T, Watanabe M, Tanaka Y, Asahina Y; Ochanomizu Liver Conference Study Group.
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: 55 Issue: 10 Pages: 990-999
- DOI
  10.1007/s00535-020-01715-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08415, KAKENHI-PROJECT-20K08303, KAKENHI-PROJECT-18H02790, KAKENHI-PROJECT-19H03635, KAKENHI-PROJECT-18K07964, KAKENHI-PROJECT-19K17392, KAKENHI-PROJECT-19K17453
[Journal Article] Vasoactive Intestinal Peptide Derived From Liver Mesenchymal Cells Mediates Tight Junction Assembly in Mouse Intrahepatic Bile Ducts2020
- Author(s)
  Sato A, Kakinuma S, Miyoshi M, Kamiya A, Tsunoda T, Kaneko S, Tsuchiya J, Shimizu T, Takeichi E, Nitta S, Kawai-Kitahata F, Murakawa M, Itsui Y, Nakagawa M, Azuma S, Koshikawa N, Seiki S, Nakauchi H, Asahina Y, Watanabe M.
- Journal Title
  
  Hepatology Communications
  
  Volume: 4 Issue: 2 Pages: 235-254
- DOI
  10.1002/hep4.1459
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07964, KAKENHI-PROJECT-19K08415, KAKENHI-PROJECT-19K08461, KAKENHI-PROJECT-19K17392, KAKENHI-PROJECT-19K17453, KAKENHI-PLANNED-17H06329, KAKENHI-PROJECT-18H02790, KAKENHI-PROJECT-17K09406, KAKENHI-PROJECT-17K09407, KAKENHI-PROJECT-17K19647, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-17K09027, KAKENHI-PROJECT-19H03635, KAKENHI-PROJECT-19H03643
[Journal Article] .Association of serum IFN-λ3 levels with hepatocarcinogenesis in chronic hepatitis C patients treated with direct-acting antiviral agents.2019
- Author(s)
  Emi Inoue-Shinomiya, Miyako Murakawa, Yasuhiro Asahina, Mina Nakagawa, Jun Tsuchiya, Ayako Sato, Tomoyuki Tsunoda, Masato Miyoshi, Sayuri Nitta, Fukiko Kawai-Kitahata, Yasuhiro Itsui, Seishin Azuma, Sei Kakinuma, Kazumoto Murata, Masashi Mizokami, Mamoru Watanabe.
- Journal Title
  
  Hepatology Research
  
  Volume: 印刷中 Issue: 5 Pages: 500-511
- DOI
  10.1111/hepr.13307
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09406, KAKENHI-PROJECT-17K09407, KAKENHI-PROJECT-18K07964, KAKENHI-PROJECT-17K19647, KAKENHI-PROJECT-16H05285, KAKENHI-PROJECT-18H02790, KAKENHI-PROJECT-17K15931, KAKENHI-PROJECT-17K15932, KAKENHI-PROJECT-19K08415, KAKENHI-PROJECT-19K17392, KAKENHI-PROJECT-17K09448
[Journal Article] Comprehensive genetic analysis of cholangiolocellular carcinoma with a coexistent hepatocellular carcinoma‐like area and metachronous hepatocellular carcinoma2019
- Author(s)
  Kawai-Kitahata F, Asahina Y, Kaneko S, Tsuchiya J, Sato A, Miyoshi M, Tsunoda T, Inoue-Shinomiya E, Murakawa M, Nitta S, Itsui Y, Nakagawa M, Azuma S, Kakinuma S, Tanabe M, Sugawara E, Takemoto A, Ojima H, Sakamoto M, Muraoka M, Takano S, Maekawa S, Enomoto N and Watanabe M.
- Journal Title
  
  Hepatology Research
  
  Volume: 49 Issue: 12 Pages: 1466-1474
- DOI
  10.1111/hepr.13403
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07964, KAKENHI-PROJECT-19K08415, KAKENHI-PROJECT-19K08461, KAKENHI-PROJECT-19K17392, KAKENHI-PROJECT-19K17453, KAKENHI-PROJECT-18H02790, KAKENHI-PROJECT-19H03635, KAKENHI-PROJECT-19H03638, KAKENHI-PROJECT-17K09406, KAKENHI-PROJECT-17K09407, KAKENHI-PROJECT-17K19647
[Journal Article] LIM homeobox 2 promotes interaction between human iPS-derived hepatic progenitors and iPS-derived hepatic stellate-like cells.2019
- Author(s)
  Miyoshi M, Kakinuma S, Kamiya A, Tsunoda T, Tsuchiya J, Sato A, Kaneko S, Nitta S, Kawai-Kitahata F, Murakawa M, Itsui Y, Nakagawa M, Azuma S, Nakauchi H, Asahina Y, Watanabe M.
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 2072-2072
- DOI
  10.1038/s41598-018-37430-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09406, KAKENHI-PROJECT-17K09407, KAKENHI-PROJECT-18K07964, KAKENHI-PROJECT-17K19647, KAKENHI-PROJECT-16H05285, KAKENHI-PROJECT-18H02790, KAKENHI-PROJECT-17K15931, KAKENHI-PROJECT-17K15932, KAKENHI-PROJECT-19H03643
[Journal Article] Impact of novel NS5A resistance-associated substitutions of hepatitis C virus detected in treatment-experienced patients2019
- Author(s)
  Nitta S, Asahina Y, Kato T, Tsuchiya J, Inoue-Shinomiya E, Sato A, Tsunoda T, Miyoshi M, Kawai-Kitahata F, Murakawa M, Itsui Y, Nakagawa M, Azuma S, Kakinuma S, Hikita H, Takehara T, Watanabe M.
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 5722-5722
- DOI
  10.1038/s41598-019-42114-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09407, KAKENHI-PROJECT-18K07964, KAKENHI-PROJECT-18H02790, KAKENHI-PROJECT-17K15931, KAKENHI-PROJECT-17K15932, KAKENHI-PROJECT-19K17392, KAKENHI-PROJECT-19K17453, KAKENHI-PROJECT-19H03635, KAKENHI-PROJECT-17K09406, KAKENHI-PROJECT-17K19647
[Journal Article] Loss of Fibrocystin Promotes Interleukin-8-Dependent Proliferation and CTGF Production of Biliary Epithelium.2019
- Author(s)
  Tsunoda T, Kakinuma S, Miyoshi M, Kamiya A, Kaneko S, Sato A, Tsuchiya J, Nitta S, Kawai-Kitahata F, Murakawa M, Itsui Y, Nakagawa M, Azuma S, Sogo T, Komatsu H, Mukouchi R, Inui A, Fujisawa T, Nakauchi H, Asahina Y, Watanabe M.
- Journal Title
  
  Journal of Heptatology
  
  Volume: 印刷中 Issue: 1 Pages: 143-152
- DOI
  10.1016/j.jhep.2019.02.024
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09406, KAKENHI-PROJECT-17K19647, KAKENHI-PROJECT-16H05285, KAKENHI-PROJECT-17K15931, KAKENHI-PROJECT-17K15932, KAKENHI-PROJECT-18K07964, KAKENHI-PROJECT-19K08415, KAKENHI-PROJECT-19K17392, KAKENHI-PROJECT-19K17453, KAKENHI-PROJECT-17H04168, KAKENHI-PROJECT-18H02790, KAKENHI-PROJECT-17K09407, KAKENHI-PROJECT-19H03643
[Journal Article] Diabetic Retinopathy as a Risk Factor Associated with the Development of Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease.2019
- Author(s)
  Azuma S, Asahina Y, Kakinuma S, Azuma K, Miyoshi M, Inoue E, Tsunoda T, Sato A, Kaneko S, Nagata H, Kawai-Kitahata F, Murakawa M, Nitta S, Itsui Y, Tomita M, Nakagawa M, Watanabe M.
- Journal Title
  
  Digestive Diseases
  
  Volume: 37 Issue: 3 Pages: 247-254
- DOI
  10.1159/000493580
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09406, KAKENHI-PROJECT-17K09407, KAKENHI-PROJECT-18K07964, KAKENHI-PROJECT-17K19647, KAKENHI-PROJECT-16H05285, KAKENHI-PROJECT-18H02790, KAKENHI-PROJECT-17K15931, KAKENHI-PROJECT-17K15932
[Journal Article] Hepatic IFNL4 expression is associated with non-response to interferonbased therapy through the regulation of basal interferon-stimulated gene expression in chronic hepatitis C patients.2017
- Author(s)
  Murakawa M, Asahina Y, Kawai-Kitahata F, Nakagawa M, Nitta S, Otani S, Nagata H, Kaneko S, Asano Y, Tsunoda T, Miyoshi M, Itsui Y, Azuma S, Kakinuma S, Tanaka Y, Iijima S, Tsuchiya K, Izumi N, Tohda S, Watanabe M.
- Journal Title
  
  J Med Virol
  
  Volume: in press Issue: 7 Pages: 1241-1247
- DOI
  10.1002/jmv.24763
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K09345, KAKENHI-PROJECT-26460987, KAKENHI-PROJECT-15K15285, KAKENHI-PROJECT-15K19316, KAKENHI-PROJECT-16K09366, KAKENHI-PROJECT-17K09406, KAKENHI-PROJECT-17K09407, KAKENHI-PROJECT-17K19647, KAKENHI-PROJECT-17K15931, KAKENHI-PROJECT-17K15932, KAKENHI-PROJECT-16H05285, KAKENHI-PROJECT-17H06655, KAKENHI-PROJECT-15K08988, KAKENHI-PROJECT-15K08989
[Journal Article] ITPA gene variation and ribavirin-induced anemia in patients with genotype 2 chronic hepatitis C treated with sofosbuvir plus ribavirin.2017
- Author(s)
  Murakawa M, Asahina Y, Nagata H, Nakagawa M, Kakinuma S, Nitta S, Kawai-Kitahata F, Otani S, Kaneko S, Miyoshi M, Tsunoda T, Asano Y, Sato A, Itsui Y, Azuma S, Nouchi T, Furumoto Y, Asano T, Chuganji Y, Tohda S, Watanabe M.
- Journal Title
  
  Hepatol Res
  
  Volume: 印刷中 Issue: 11 Pages: 1212-1218
- DOI
  10.1111/hepr.12867
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H05285, KAKENHI-PROJECT-15K15285, KAKENHI-PROJECT-15K19316, KAKENHI-PROJECT-17K09406, KAKENHI-PROJECT-17K09407, KAKENHI-PROJECT-17K19647, KAKENHI-PROJECT-17K15931, KAKENHI-PROJECT-17K15932, KAKENHI-PROJECT-17H06655, KAKENHI-PROJECT-15K08988, KAKENHI-PROJECT-15K08989
[Journal Article] Effect of interferon-based and -free therapy on early occurrence and recurrence of hepatocellular carcinoma in chronic hepatitis C.2017
- Author(s)
  Nagata H, Nakagawa M, Asahina Y, Sato A, Asano Y, Tsunoda T, Miyoshi M, Kaneko S, Otani S, Kawai-Kitahata F, Murakawa M, Nitta S, Itsui Y, Azuma S, Kakinuma S, Nouchi T, Sakai H, Tomita M, Watanabe M
- Journal Title
  
  J Hepatol
  
  Volume: 67 Issue: 5 Pages: 933-939
- DOI
  10.1016/j.jhep.2017.05.028
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09406, KAKENHI-PROJECT-17K09407, KAKENHI-PROJECT-17K19647, KAKENHI-PROJECT-17K15931, KAKENHI-PROJECT-17K15932, KAKENHI-PROJECT-16H05285, KAKENHI-PROJECT-17H06655, KAKENHI-PROJECT-15K08988, KAKENHI-PROJECT-15K08989
[Journal Article] Human induced pluripotent stem cell-derived hepatic cell line as a new model for host interaction with hepatitis B virus.2016
- Author(s)
  Kaneko S, Kakinuma S, Asahina Y, Kamiya A, Miyoshi M, Tsunoda T, Nitta S, Asano Y, Nagata H, Otani S, Kitahata F, Murakawa M, Itsui Y, Nakagawa M, Azuma S, Nakauchi H, Iwamoto M, Watashi K, Wakita T, Sugiyama M, Mizokami M, Shimotohno K, Watanabe M.
- Journal Title
  
  Sci Rep
  
  Volume: ６ Issue: 1 Pages: 29358-29358
- DOI
  10.1038/srep29358
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H05285, KAKENHI-PROJECT-26293178, KAKENHI-PROJECT-16K09345, KAKENHI-PROJECT-26460987, KAKENHI-PROJECT-15K15285, KAKENHI-PROJECT-15K19316, KAKENHI-PROJECT-15K08988, KAKENHI-PROJECT-15K08989, KAKENHI-PROJECT-26460565
[Journal Article] Comprehensive analyses of mutations and hepatitis B virus integration in hepatocellular carcinoma with clinicopathological features.2016
- Author(s)
  Kawai-Kitahata F, Asahina Y, Tanaka S, Kakinuma S, Murakawa M, Sayuri Nitta S, Watanabe T, Otani S, Taniguchi M, Goto F, Nagata H, Kaneko S, Tasaka-Fujita M, Nishimura-Sakurai Y, Azuma S, Itsui Y, Nakagawa M, Tanabe M, Takano S, Fukasawa M, Sakamoto M, Maekawa S, Enomoto N, Watanabe M.
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: 51 Issue: 5 Pages: 473-486
- DOI
  10.1007/s00535-015-1126-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25253081, KAKENHI-PROJECT-26460986, KAKENHI-PROJECT-26670380, KAKENHI-PROJECT-25293169, KAKENHI-PROJECT-16H02670, KAKENHI-PROJECT-16H05285, KAKENHI-PROJECT-16K09345, KAKENHI-PROJECT-15K15285, KAKENHI-PROJECT-15K19316, KAKENHI-PROJECT-15K08988, KAKENHI-PROJECT-15K08989, KAKENHI-PROJECT-15K08995
[Journal Article] Efficacy of additional radiofrequency ablation after transcatheter arterial chemoembolization for intermediate hepatocellular carcinoma.2016
- Author(s)
  Azuma S, Asahina Y, Nishimura-Sakurai Y, Kakinuma S, Kaneko S, Nagata H, Goto F, Ootani S, Kawai-Kitahata F, Taniguchi M, Murakawa M, Watanabe T, Tasaka-Fujita M, Itsui Y, Nakagawa M, Watanabe M.
- Journal Title
  
  Heptol Res
  
  Volume: 46 Issue: 4 Pages: 312-9
- DOI
  10.1111/hepr.12566
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08988, KAKENHI-PROJECT-26460986, KAKENHI-PROJECT-25293169, KAKENHI-PROJECT-15K08989, KAKENHI-PROJECT-16H05285, KAKENHI-PROJECT-16K09345, KAKENHI-PROJECT-15K15285
[Journal Article] Evaluation of IFN resistance in newly established genotype 1b HCV cell culture system.2016
- Author(s)
  Taniguchi M, Tasaka-Fujita M, Nakagawa M, Watanabe T, Kawai-Kitahata F, Otani S, Goto F, Nagata H, Kaneko S, Nitta S, Murakawa M, Nishimura-Sakurai Y, Azuma S, Itsui Y, Mori K, Yagi S, Kakinuma S, Asahina Y, Watanabe M.
- Journal Title
  
  J Clin Transl Hepatol
  
  Volume: 4 Issue: 1 Pages: 5-11
- DOI
  10.14218/jcth.2015.00047
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08988, KAKENHI-PROJECT-26460986, KAKENHI-PROJECT-25293169, KAKENHI-PROJECT-15K08989, KAKENHI-PROJECT-16H05285, KAKENHI-PROJECT-26460987, KAKENHI-PROJECT-15K15285, KAKENHI-PROJECT-15K19316
[Journal Article] Serial measurement of Wisteria floribunda agglutinin positive Mac-2-binding protein is useful for predicting liver fibrosis and the development of hepatocellular carcinoma in chronic hepatitis C patients treated with IFN-based and IFN-free therapy.2016
- Author(s)
  Nagata H, Nakagawa M, Nishimura-Sakurai Y, Asano Y, Tsunoda T, Miyoshi M, Kaneko S, Goto F, Otani S, Kawai-Kitahata F, Murakawa M, Nitta S, Itsui Y, Seishin Azuma S, Kakinuma S, Tojo N, Tohda T, Asahina Y, Watanabe M, the Ochanomizu Liver Conference Study Group.
- Journal Title
  
  Hepatol Int
  
  Volume: 10 Issue: 6 Pages: 956-964
- DOI
  10.1007/s12072-016-9754-1
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H05285, KAKENHI-PROJECT-16K09345, KAKENHI-PROJECT-26460987, KAKENHI-PROJECT-15K15285, KAKENHI-PROJECT-15K08988, KAKENHI-PROJECT-15K08989
[Journal Article] Bone Morphogenetic Protein-4 Modulates Proliferation and Terminal Differentiation of Fetal Hepatic Stem/Progenitor Cells.2016
- Author(s)
  Goto F, Kakinuma S, Miyoshi M, Tsunoda T, Kaneko S, Sato A, Asano Y, Otani S, Azuma S, Nagata H, Kawai-Kitahata F, Murakawa M, Nitta S, Itsui Y, Nakagawa M, Asahina Y, Watanabe M.
- Journal Title
  
  Hepatol Res
  
  Volume: 印刷中 Issue: 9 Pages: 941-952
- DOI
  10.1111/hepr.12823
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H05285, KAKENHI-PROJECT-16K09345, KAKENHI-PROJECT-26460987, KAKENHI-PROJECT-15K15285, KAKENHI-PROJECT-15K19316, KAKENHI-PROJECT-15K08988, KAKENHI-PROJECT-15K08989, KAKENHI-PROJECT-17K19647, KAKENHI-PROJECT-17K15931
[Journal Article] Matrix Metalloproteinase-14 Mediates Formation of Bile Ducts and Hepatic Maturation of Fetal Hepatic Progenitor Cells.2016
- Author(s)
  Otani S, Kakinuma S, Kamiya A, Goto F, Kaneko S, Miyoshi M, Tsunoda T, Asano Y, Kawai-Kitahata F, Nitta S, Nakata T, Okamoto R, Itsui Y, Nakagawa M, Azuma S, Asahina Y, Yamaguchi T, Koshikawa N, Seiki M, Nakauchi H, Watanabe M.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 469 Issue: 4 Pages: 1062-1068
- DOI
  10.1016/j.bbrc.2015.12.105
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08988, KAKENHI-PROJECT-26460358, KAKENHI-PROJECT-26460987, KAKENHI-PROJECT-15K15285, KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-25293169, KAKENHI-PROJECT-25293170, KAKENHI-PROJECT-15K08989, KAKENHI-PROJECT-16H05285
[Journal Article] Impaired induction of IL28B and expression of IFNλ4 associated with non-response to interferon-based therapy in chronic hepatitis C.2015
- Author(s)
  Murakawa M, Asahina Y, Nakagawa M, Sakamoto N, Nitta S, Kusano-Kitazume A, Watanabe T, Kawai-Kitahata F, Otani S, Taniguchi M, Goto F, Nishimura-Sakurai Y, Itsui Y, Azuma S, Kakinuma S, Watanabe M
- Journal Title
  
  J Gastroenterol Hepatol
  
  Volume: 印刷中 Issue: 6 Pages: 1075-84
- DOI
  10.1111/jgh.12902
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390185, KAKENHI-PROJECT-24590957, KAKENHI-PROJECT-24590958, KAKENHI-PROJECT-24590960, KAKENHI-PROJECT-25670366, KAKENHI-PROJECT-26460986, KAKENHI-PROJECT-26460987, KAKENHI-PROJECT-26460988, KAKENHI-PROJECT-26670375, KAKENHI-PROJECT-15K08988, KAKENHI-PROJECT-15K19316, KAKENHI-PROJECT-15K08989
[Journal Article] Impaired induction of interleukin 28B and expression of interferon λ 4 associated with nonresponse to interferon-based therapy in chronic hepatitis C.2015
- Author(s)
  Murakawa M, Asahina Y, Nakagawa M, Sakamoto N, Nitta S, Kusano-Kitazume A, Watanabe T, Kawai-Kitahata F, Otani S, Taniguchi M, Goto F, Nishimura-Sakurai Y, Itsui Y, Azuma S, Kakinuma S, Watanabe M.
- Journal Title
  
  J Gastroenterol Hepatol.
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590959
[Journal Article] Primary hepatic neuroendocrine carcinoma with a cholangiocellular carcinoma component in one nodule.2014
- Author(s)
  Kano Y, Kakinuma S, Goto F, Azuma S, Nishimura-Sakurai Y, Itsui Y, Nakagawa M, Kudo A, Tanabe M, Kirimura S, Amano T, Ito T, Akashi T, Asahina Y, Watanabe M.
- Journal Title
  
  Clin J Gastroenterol
  
  Volume: 7 Issue: 5 Pages: 449-454
- DOI
  10.1007/s12328-014-0521-3
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590957, KAKENHI-PROJECT-24590959
[Journal Article] Matrix Metalloproteinase-14 regulates the maturation of fetal hepatic stem/progenitor cells in mice2014
- Author(s)
  Otani S, Kakinuma S, Kamiya A, Goto F, Kaneko S, Azuma S, Asahina Y, Watanabe M
- Journal Title
  
  Hepatology
  
  Volume: 60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590959
[Journal Article] Association of ITPA gene variant and serum ribavirin concentration with blood cells decline in pegylated interferon-alfa plus ribavirin therapy for chronic hepatitis C2013
- Author(s)
  Nakagawa M, Azuma S, Kakinuma S, Watanabe M, et al.
- Journal Title
  
  Hepatol Int
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590959
[Journal Article] Hepatitis C virus NS4B protein targets STING and abrogates RIG-I-mediated type-I interferon-dependent innate immunity2013
- Author(s)
  Nitta S, Sakamoto N, Nakagawa M, Kakinuma S, Mishima K, Kusano-kitazume A, Kiyohashi K, Murakawa M, Nishimura-Sakurai Y, Azuma S, Tasaka-Fujita M, asahina Y, Yoneyama M, Fujita T, Watanabe M
- Journal Title
  
  Hepatology
  
  Volume: 57 Issue: 1 Pages: 46-58
- DOI
  10.1002/hep.26017
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20112009, KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-23390108, KAKENHI-PROJECT-23790778, KAKENHI-PROJECT-24390185, KAKENHI-PROJECT-24590957, KAKENHI-PROJECT-24590958, KAKENHI-PROJECT-24590959, KAKENHI-PROJECT-24590960, KAKENHI-PROJECT-24659359, KAKENHI-PROJECT-24890058, KAKENHI-PROJECT-25293169, KAKENHI-PROJECT-25670366, KAKENHI-PROJECT-25860522
[Journal Article] Wnt5a Signaling Mediates Biliary Differentiation of Fetal Hepatic Stem/Progenitor Cells2013
- Author(s)
  Kakinuma S, Kiyohashi K, Kamiya A, Sakamoto N, Nitta S, Yamanaka H, YoshinoK, Fujiki J, Murakawa M, Kusano-Kitazume A, Shimizu H, Okamoto R, Azuma S, Nakagawa M, Asahina Y, Tanimizu N, Kikuchi A, Nakauchi H, and *WatanabeM
- Journal Title
  
  Hepatology
  
  Volume: (in press) Issue: 6 Pages: 2502-2513
- DOI
  10.1002/hep.26293
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590831, KAKENHI-ORGANIZER-23112001, KAKENHI-PLANNED-23112004, KAKENHI-PROJECT-23689040, KAKENHI-PROJECT-23790777, KAKENHI-PUBLICLY-24112505, KAKENHI-PUBLICLY-24112519, KAKENHI-PROJECT-24390304, KAKENHI-PROJECT-24590957, KAKENHI-PROJECT-24590958, KAKENHI-PROJECT-24590959, KAKENHI-PROJECT-24590960, KAKENHI-PROJECT-24659359, KAKENHI-PROJECT-25250018, KAKENHI-PROJECT-25293169, KAKENHI-PROJECT-25293289, KAKENHI-PROJECT-25460271, KAKENHI-PROJECT-25670366, KAKENHI-PROJECT-25860522, KAKENHI-PLANNED-23102003, KAKENHI-PLANNED-23106004
[Journal Article] 多血性肝細胞癌の検出能に関するGd-EOB-DTPA造影MRIとCTAP/CTHAとの比較検討2013
- Author(s)
  東正新、柿沼晴、渡辺守、他
- Journal Title
  
  医学と薬学
  
  Volume: 69 Pages: 64-66
- Data Source
  KAKENHI-PROJECT-24590959
[Journal Article] Identification of novel N-(morpholine-4-carbonyloxy) amidine compounds as potent inhibitors against hepatitis C virus replication2012
- Author(s)
  Kusano-Kitazume A, Sakamoto N, Okuno Y, Sekine-Osajima Y, Nakagawa M, Kakinuma S, Kiyonashi K, Nitta S, Murakawa M, Azuma S, Nishimura-Sakurai Y, Hagiwara M, Watanabe M
- Journal Title
  
  Antimicrob Agent Chemother
  
  Volume: 56(3) Issue: 3 Pages: 1315-23
- DOI
  10.1128/aac.05764-11
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-21590832, KAKENHI-PROJECT-23790778, KAKENHI-PROJECT-24390185, KAKENHI-PROJECT-24590957, KAKENHI-PROJECT-24590959, KAKENHI-PROJECT-24659359, KAKENHI-PROJECT-21249013
[Journal Article] Identification of novel N-(morpholine-4-carbonyloxy) amidine compounds as potent inhibitors against hepatitis C virus replication2012
- Author(s)
  Kusano-Kitazume A, Sakamoto N, Okuno Y, Sekine-Osajima Y, Nakagawa M, Kakinuma S, Kiyonashi K, Nitta S, Murakawa M, Azuma S, Nishimura-Sakurai Y, Hagiwara M, Watanabe M
- Journal Title
  
  Antimicrob Agent Chemother
  
  Volume: 56(3) Pages: 1315-1323
- Data Source
  KAKENHI-PROJECT-21390226
[Journal Article] Let-7b is a novel regulator of hepatitis C virus replication. Cell Mol Life Sci 20122012
- Author(s)
  Cheng J-C, Yeh YJ, Tseng CP, Hsu SD, Chang YL, Sakamoto N, Huang HD
- Journal Title
  
  EPub ahead of Print
  
  Volume: 69 Issue: 15 Pages: 2621-2633
- DOI
  10.1007/s00018-012-0940-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390226, KAKENHI-PROJECT-24390185, KAKENHI-PROJECT-24659359
[Journal Article] Identification of novel N-(morpholine-4-carbonyloxy) amidine compounds as potent inhibitors against hepatitis C virus replication2012
- Author(s)
  Kusano-Kitazume A, Sakamoto N, Okuno Y, Sekine-Osajima Y, Nakagawa M, Kakinuma S, Kiyonashi K, Nitta S, Murakawa M, Azuma S, Nishimura-Sakurai Y, Hagiwara M, Watanabe M
- Journal Title
  
  Antimicrob Agent Chemother
  
  Volume: 56(3) Pages: 1315-23
- Data Source
  KAKENHI-PROJECT-21590833
[Journal Article] Ochanomizu Liver Conference Study Group : Association of ITPA gene variant and serum ribavirin concentration with blood cells decline in pegylated interferon-alfa plus ribavirin therapy for chronic hepatitis C2012
- Author(s)
  Nakagawa M, Sakamoto N, Watanabe T, Nishimura-Sakurai Y, Onozuka I, Azuma S, Kakinuma S, Nitta S, Kiyohashi K, Kusano-Kitazume A, Murakawa M, Yoshino K, Itsui Y, Tanaka Y, Mizokami M, Watanabe M
- Journal Title
  
  Hepatol Int
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-21590833
[Journal Article] Serum interleukin-6 levels can predict resistance to treatment of chronic hepatitis C infection with pegylated-interferon alpha 2b plus ribavirin.2011
- Author(s)
  Mayumi Ueyama, Mina Nakagawa, Naova Sakamoto, Seishin Azuma, Mamoru Watanabe, et al.
- Journal Title
  
  Antivral Therapy
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390226
[Journal Article] The inhibitory effect on hepatitis C virus infection of a triterpenoid compound, with or without interferon-alpha2011
- Author(s)
  Watanabe T, Sakamoto N, Nakagawa M, Kakinuma S, Itsui Y, Nishimura-Sakurai Y, Ueyama M, Funaoka Y, Kitazume A, Nitta S, Kiyohashi K, Murakawa M, Azuma S, Tsuchiya K, Oooka S, Watanabe M
- Journal Title
  
  Antimicrob Agents Chemother
  
  Volume: 55(6) Pages: 2537-2545
- Data Source
  KAKENHI-PROJECT-21590832
[Journal Article] Studies on virus kinetics using infectious fluorescence-tagged hepatitis C virus cell culture2011
- Author(s)
  Yamamoto M, Sakamoto N, Nakamura T, Itsui Y, Nakagawa M, Nishimura-Sakurai Y, Kakinuma S, Azuma S, Kato T, Wakita T, Watanabe M
- Journal Title
  
  Hepatol Res
  
  Volume: 41 Issue: 3 Pages: 258-269
- DOI
  10.1111/j.1872-034x.2010.00771.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-21590832, KAKENHI-PROJECT-22790633, KAKENHI-PROJECT-23790778
[Journal Article] Association of IL28B polymorphism withresponse to pegylated-interferon alpha plusribavirin combination therapy in patientswith chronic genotype 2 hepatitis C2011
- Author(s)
  Sakamoto N, Nakagawa M, Tanaka Y, Sekine-Osajima Y, Ueyama M, Kurosaki M, Nishida N, Tamori A, Nishimura-Sakurai Y, Itsui Y, Azuma S, Kakinuma S, Hige S, Ito Y, Tanaka E, Hiasa Y, Izumi N, Tokunaga K, Mizokami M, Watanabe M
- Journal Title
  
  JMedical Virol
  
  Volume: 83 Pages: 871-878
- Data Source
  KAKENHI-PROJECT-21590833
[Journal Article] Serum interleukin-6 levels can predict resistance to treatment of chronic hepatitis C infection with pegylated-interferon alpha 2b plus ribavirin2011
- Author(s)
  Ueyama M, Nakagawa M, Sakamoto N, Onozuka I, Funaoka Y, Watanabe T, Nitta S, Kiyohashi K, Kitazume A, Murakawa M, Nishimura-Sakurai Y, Sekine-Osajima Y, Itsui Y, Azuma S, Kakinuma S, Watanabe M
- Journal Title
  
  Antivir Ther
  
  Volume: 16 Pages: 1081-1091
- Data Source
  KAKENHI-PROJECT-21590833
[Journal Article] Studies on virus kinetics using infectious fluorescence-tagged hepatitis C virus cell culture2011
- Author(s)
  Yamamoto M, Sakamoto N, Nakamura T, Itsui Y, Nakagawa M, Nishimura-Sakurai Y, Kakinuma S, Azuma S, Tsuchiya K, Kato T, Wakita T, Watanabe M
- Journal Title
  
  Hepatol Res
  
  Volume: 41 Pages: 258-269
- Data Source
  KAKENHI-PROJECT-21390226
[Journal Article] The inhibitory effect on hepatitis C virus infection of a triterpenoid compound, with or without interferon-alpha2011
- Author(s)
  Watanabe T, Sakamoto N, Nakagawa M, Kakinuma S, Itsui Y, Nishimura-Sakurai Y, Ueyama M, Funaoka Y, Kitazume A, Nitta S, Kiyohashi K, Murakawa M, Azuma S, Tsuchiya K, Oooka S, Watanabe M
- Journal Title
  
  Antimicrob Agents Chemother
  
  Volume: 55(6) Pages: 2537-2545
- Data Source
  KAKENHI-PROJECT-21390226
[Journal Article] Association of IL28B variants with response to pegylated-interferon alpha plus ribavirin combination therapy reveals intersubgenotypic differences between genotypes 2a and 2b2011
- Author(s)
  Sakamoto N, Nakagawa M, Azuma S, Watanabe M, et al.
- Journal Title
  
  J Med Virol
  
  Volume: 83 Issue: 5 Pages: 871-878
- DOI
  10.1002/jmv.22038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390226, KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-21590832, KAKENHI-PROJECT-21590833, KAKENHI-PROJECT-22390151, KAKENHI-PROJECT-22659145, KAKENHI-PROJECT-22710191, KAKENHI-PROJECT-22790633, KAKENHI-PROJECT-23390117, KAKENHI-PROJECT-23790778
[Journal Article] Analysis of interferon signaling by infectious hepatitis C virus clones with substitutions of core amino acids 70 and 912011
- Author(s)
  Funaoka Y, Sakamoto N, Suda G, Itsui Y, Nakagawa M, Kakinuma S, Watanabe T, Nitta S, Kitazume A, Kiyohashi K, Murakawa M, Azuma S, Tsuchiya K,Watanabe M
- Journal Title
  
  J Virol
  
  Volume: 85 Issue: 12 Pages: 5986-94
- DOI
  10.1128/jvi.02583-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-21590832, KAKENHI-PROJECT-22790633, KAKENHI-PUBLICLY-23130506
[Journal Article] Analysis of interferon signaling by infectious hepatitis C virus clones with substitutions of core amino acids 70 and 912011
- Author(s)
  Funaoka Y, Sakamoto N, Suda G, Itsui Y, Nakagawa M, Kakinuma S, Watanabe T, Nitta S, Kitazume A, Kiyohashi K, Murakawa M, Azuma S, Tsuchiya K, Watanabe M
- Journal Title
  
  J Virol
  
  Volume: 85 Pages: 5986-94
- Data Source
  KAKENHI-PROJECT-21590833
[Journal Article] Inhibitory effect of a triterpenoid compound, with or without alpha interferon, on hepatitis C virus infection2011
- Author(s)
  Watanabe T, Sakamoto N, Nakagawa M, Azuma S, Watanabe M, et al.
- Journal Title
  
  Antimicrob Agents Chemother
  
  Volume: 55(6) Issue: 6 Pages: 2537-2545
- DOI
  10.1128/aac.01780-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390226, KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-21590832, KAKENHI-PROJECT-22659145, KAKENHI-PROJECT-22790633, KAKENHI-PUBLICLY-23130506, KAKENHI-PROJECT-23790778
[Journal Article] Analysis of interferon signaling by infectious hepatitis C virus clones with substitutions of core amino acids 70 and 912011
- Author(s)
  Funaoka Y, Sakamoto N, Nakagawa M, Kakinuma S, Suda S, Watanabe T, Nitta S, Kitazume A, Kiyohashi K, Murakawa M, Azuma S, Tsuchiya K, and Watanabe M
- Journal Title
  
  J Virol
  
  Volume: 85(12) Pages: 5986-5994
- Data Source
  KAKENHI-PROJECT-21390226
[Journal Article] Analysis of interferon signaling by infectious hepatitis C virus clones with substitutions of core amino acids 70 and 912011
- Author(s)
  Funaoka Y, Sakamoto N, Kakinuma S, Azuma S, Watanabe M, et al
- Journal Title
  
  Journal of Virology
  
  Volume: 85 Pages: 5986-94
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590833
[Journal Article] Serum interleukin-6 levels correlate with resistance to treatment of chronic hepatitis C infection withpegylated-interferon-α2b plus ribavirin2011
- Author(s)
  Ueyama M, Nakagawa M, Sakamoto N,Onozuka I, Funaoka Y, Watanabe T, Nitta S, Kiyohashi K, Kitazume A, Murakawa M, Nishimura-Sakurai Y, Sekine-Osajima Y, Itsui Y, Azuma S, Kakinuma S, Watanabe M and the Ochanomizu-Liver Conference Study Group
- Journal Title
  
  Antivir Ther
  
  Volume: 16 Issue: 7 Pages: 1081-1091
- DOI
  10.3851/imp1864
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-23790778
[Journal Article] Inhibitory effect of triterpenoid compound, with or without interferon-alpha, on hepatitis C virus infection2011
- Author(s)
  Watanabe T, Sakamoto N, Nakagawa M, Kakinuma S, Itsui Y, Nishimura-Sakurai Y, Ueyama M, Funaoka Y, Kitazume A, Nitta S, Kiyohashi K, Murakawa M, Azuma S, Tsuchiya K, Oooka S, Watanabe M
- Journal Title
  
  Antimicrob Agent Chemother
  
  Volume: 55 Pages: 2537-45
- Data Source
  KAKENHI-PROJECT-21590833
[Journal Article] ITPA gene variant protects against anemia induced by pegylated interferon-alfa and ribavirin therapy for Japanese patients with chronic hepatitis C2010
- Author(s)
  Sakamoto N, Tanaka Y, Nakagawa M, Yatsuhashi H, Nishiguchi S, Enomoto N, Azuma S, Nishimura-Sakurai Y, Kakinuma S, Nishida N, Tokunaga K, Honda M, Ito K, Mizokami M, Watanabe M
- Journal Title
  
  Hepatol Res
  
  Volume: 40 Pages: 1063-1071
- Data Source
  KAKENHI-PROJECT-21590833
[Journal Article] SR蛋白リン酸化酵素阻害剤によるHCV増殖抑制効果の解析2010
- Author(s)
  唐鎌優子、坂本直哉、井津井康浩、中川美奈、藤田めぐみ、櫻井幸、柿沼晴、大岡真也、東正新、土屋輝一郎、小野木博、萩原正敏、渡辺守
- Journal Title
  
  消化器内科
  
  Volume: 51(6) Pages: 632-635
- Data Source
  KAKENHI-PROJECT-21590832
[Journal Article] Cell culture and in vivo analyses of cytopathic hepatitis C virus mutants2010
- Author(s)
  Mishima K, Sakamoto N, Sekine-Osajima Y, Nakagawa M, Itsui Y, Azuma S, Kakinuma S, Kiyohashi K, Kitazume A, Tsuchiya K, Imamura M, Hiraga N, Chayama K, Wakita T, Watanabe M
- Journal Title
  
  Virology
  
  Volume: 405 Pages: 361-369
- Data Source
  KAKENHI-PROJECT-21390226
[Journal Article] Cell culture and in-vivo analyses of plaque-derived cytopathic hepatitis Cvirus mutants.2010
- Author(s)
  Suda G, Sakamoto N, Azuma S
- Journal Title
  
  Virology
  
  Volume: 405 Pages: 361-369
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590833
[Journal Article] Inhibition of HCV replication by a specific inhibitor of serin-arginine-rich protein kinase2010
- Author(s)
  Karakama Y, Sakamoto N, Kakinuma S, Azuma S, Watanabe M, et al.
- Journal Title
  
  Antimicrobial Agents and Chemotherapy
  
  Volume: 54 Pages: 3179-3186
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590833
[Journal Article] IL-6-mediated intersubgenotypic variation of interferon sensitivity in hepatitis C virus genotype 2a/2b chimeric clones2010
- Author(s)
  Suda G, Sakamoto N, Itsui Y, Nakagawa M, Tasaka-Fujita M, Funaoka Y, Watanabe T, Nitta S, Kiyohashi K, Azuma S, Kakinuma S, Tsuchiya K, Imamura M, Hiraga N, Chayama K, Watanabe M
- Journal Title
  
  Virology
  
  Volume: 407 Pages: 80-90
- Data Source
  KAKENHI-PROJECT-21390226
[Journal Article] Mutations in the interferon sensitivity determining region and virological response to combination therapy with pegylated-interferon alpha 2b plus ribavirin in patients with chronic hepatitis C-1b infection2010
- Author(s)
  Nakagawa M, Sakamoto N, Ueyama M, Mogushi K, Nagaie S, Itsui Y, Azuma S, Kakinuma S, Tanaka H, Enomoto N, Watanabe M
- Journal Title
  
  J Gastroentorol
  
  Volume: 45 Pages: 656-665
- NAID
  10027216778
- Data Source
  KAKENHI-PROJECT-21590833
[Journal Article] Inhibition of HCV replication by a specific inhibitor of serin-arginine-rich protein kinase2010
- Author(s)
  Karakama Y, Sakamoto N, Itsui Y, Nakagawa M, Tasaka-Fujita M, Nishimura-Sakurai Y, Kakinuma S, Oooka S, Azuma S, Tsuchiya K, Onogi H, Hagiwara M, Watanabe M
- Journal Title
  
  Antimicrob AgentChemother
  
  Volume: 54 Pages: 3179-86
- Data Source
  KAKENHI-PROJECT-21590833
[Journal Article] IL-6-mediated intersubgenotypic variation of interferon sensitivity in hepatitis C virus genotype 2a/2b chimeric clones2010
- Author(s)
  Suda G, Sakamoto N, Itsui Y, Nakagawa M, Mishima K, Onuki-Karakama Y, Yamamoto M, Funaoka Y, Watanabe T, Kiyohashi K, Nitta S, Azuma S, Kakinuma S, Tuchiya K, Imamura M, Hiraga N, Chayama K, Watanabe M
- Journal Title
  
  Virology
  
  Volume: 407 Pages: 80-90
- Data Source
  KAKENHI-PROJECT-21590833
[Journal Article] Inhibition of hepatitis C virus replication by a specific inhibitor of serine-arginine-rich protein kinase2010
- Author(s)
  Karakama Y, Sakamoto N, Itsui Y, Nakagawa M, Tasaka-Fujita M, Nishimura-Sakurai Y, Kakinuma S, Oooka M, Azuma S, Tsuchiya K, Onogi H, Hagiwara M, Watanabe M
- Journal Title
  
  Antimicrob Agents Chemother
  
  Volume: 54 Pages: 3179-3186
- Data Source
  KAKENHI-PROJECT-21390226
[Journal Article] Comparison of HCV-associated gene expression and cell signaling pathways in cells with or without HCV replicon and in replicon-cured cells2010
- Author(s)
  Nishimura-Sakurai Y, Sakamoto N, Kakinuma S, Azuma S, Watanabe M, et al.
- Journal Title
  
  Journal of Gastroenterorlogy (印刷中(Epub ahead of print))
- NAID
  10027216127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590833
[Journal Article] IL-6-mediated intersubgenotypic variation of interferon sensitivity in hepatitis C virus genotype 2a/2b chimeric clones.2010
- Author(s)
  Suda G, Sakamoto N, Azuma S, Kakinuma S, Watanabe M, et al.
- Journal Title
  
  Virology
  
  Volume: 407 Pages: 80-90
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590833
[Journal Article] Cell culture and in-vivo analyses of plaque-derived cytopathic hepatitis C virus mutants2010
- Author(s)
  Mishima K, Sakamoto N, Sekine-Osajima Y, Nakagawa M, Itsui Y, Azuma S, Kakinuma S, Tuchiya K, Imamura M, Chayama K, Wakita T, Watanabe M
- Journal Title
  
  Virology
  
  Volume: 405 Pages: 361-369
- Data Source
  KAKENHI-PROJECT-21590833
[Journal Article] Comparison of HCV-associated gene expression and cell signaling pathways in cells with or without HCV replicon and in replicon-cured cells2010
- Author(s)
  Nishimura-Sakurai Y, Sakamoto N, Mogushi K, Nagaie S, Nakagawa M, Itsui Y, Sekine-Osajima Y, Tasaka-Fujita M, Onuki-Karakama Y, Suda G, Mishima M, Yamamoto M, Ueyama M, Funaoka Y, Watanabe T, Chen CH, Kakinuma S, Tsuchiya K, Tanaka H, Enomoto N, Watanabe
- Journal Title
  
  J Gastroentorol
  
  Volume: 45 Pages: 523-36
- NAID
  10027216127
- Data Source
  KAKENHI-PROJECT-21590833
[Journal Article] Cell culture and in vivo analyses of cytopathic hepatitis C virus mutants2010
- Author(s)
  Mishima K, Sakamoto N, Sekine-Osajima Y, Nakagawa M, Itsui Y, Azuma S, Kakinuma S, Kiyohashi K, Kitazume A, Tsuchiya K, Imamura M, Hiraga N, Chayama K, Wakita T, Watanabe M
- Journal Title
  
  Virology
  
  Volume: 405 Pages: 361-369
- Data Source
  KAKENHI-PROJECT-21590832
[Journal Article] ITPA gene variant protects against anemia induced by pegylated interferon-alpha and ribavirin therapy for Japanese patients with chronic hepatitis C2010
- Author(s)
  Sakamoto N, Tanaka Y, Nakagawa M, Yatsuhashi H, Nishiguchi S, Enomoto N, Azuma S, Nishimura-Sakurai Y, Kakinuma S, Nishida N, Tokunaga K, Honda M, Ito K, Mizokami M, Watanabe M
- Journal Title
  
  Hepatol Res
  
  Volume: 40 Pages: 1063-1071
- Data Source
  KAKENHI-PROJECT-21390226
[Journal Article] Antiviral effects of the interferon-induced protein GBP-1 and its interaction with the hepatitis C virus NS5B protein2009
- Author(s)
  Itsui Y, Sakamoto N, Kakinuma S, Nakagawa M, Sekine-Osajima Y, Tasaka-Fujita M, Nishimura-Sakurai Y, Suda G, Karakama Y, Mishima K, Yamamoto M, Watanabe T, Ueyama M, Funaoka Y, Azuma S, Watanabe M
- Journal Title
  
  Hepatology
  
  Volume: 50 Pages: 1727-37
- Data Source
  KAKENHI-PROJECT-21590833
[Journal Article] Antiviral effects of the interferon-induced protein GBP-1 and its interaction with the hepatitis C virus NS5B protein.2009
- Author(s)
  Itsui Y, Sakamoto N, Kakinuma S, Azuma S, Watanabe M, et al.
- Journal Title
  
  Hepatology 50
  
  Pages: 1727-37
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590833
[Journal Article] Antiviral effects of the interferon-induced protein guanylate binding protein 1 and its interaction with the hepatitis C virus NS5Bprotein2009
- Author(s)
  Itsui Y, Sakamoto N, Kakinuma S, Nakagawa M, Sekine-Osajima Y, Tasaka-Fujita M, Nishimura-Sakurai Y, Suda G, Karakama Y, Mishima K, Yamamoto M, Watanabe T, Ueyama M, Funaoka Y, Azuma S, Watanabe M
- Journal Title
  
  Hepatology
  
  Volume: 50(6) Issue: 6 Pages: 1727-37
- DOI
  10.1002/hep.23195
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590831
[Journal Article] Two flavonoids extracts from a herb, Glycyrrhizae radix, inhibit in-vitro hepatitis C virus replication2009
- Author(s)
  Sekine-Osajima Y, Sakamoto N, Nakagawa M, Itsui Y, Tasaka M, Nishimura-Sakurai Y, Chen CH, Suda G, Mishima K, Onuki Y, Yamamoto M, Maekawa S, Enomoto N, Kanai T, Tsuchiya K, Watanabe M
- Journal Title
  
  Hepatology Res 39(1)
  
  Pages: 60-69
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390196
[Journal Article] Two flavonoids extracts from Glycyrrhizae radix inhibit in vitro hepatitis C virus replication2009
- Author(s)
  Sekine-Osajima Y, Sakamoto N, Nakagawa M, Itsui Y, Tasaka M, Nishimura-Sakurai Y, Chen CH, Suda G, Mishima K, Onuki Y, Yamamoto M, Maekawa S, Enomoto N, Kanai T, Tsuchiya K, Watanabe M
- Journal Title
  
  Hepatol Res
  
  Volume: 39 Pages: 60-69
- NAID
  10025324061
- Data Source
  KAKENHI-PROJECT-21590832
[Journal Article] Two flavonoids extracts from Glycyrrhizae radix inhibit in vitro hepatitis C virus replication2009
- Author(s)
  Sekine-Osajima Y, Sakamoto N, Nakagawa M, Itsui Y, Tasaka M, Nishimura-Sakurai Y, Chen CH, Suda G, Mishima K, Onuki Y, Yamamoto M, Maekawa S, Enomoto N, Kanai T, Tsuchiya K, Watanabe M
- Journal Title
  
  Hepatol Res
  
  Volume: 39 Pages: 60-69
- NAID
  10025324061
- Data Source
  KAKENHI-PROJECT-21390226
[Journal Article] Antiviral effects of the interferon-induced protein guanylate binding protein 1 and its interaction with the hepatitis C virus NS5B protein2009
- Author(s)
  Itsui Y, Sakamoto N, Kakinuma S, Nakagawa M, Sekine-Osajima Y, Tasaka-Fujita M, Nishimura-Sakurai Y, Suda G, Karakama Y, Mishima K, Yamamoto M, Watanabe T, Ueyama M, Funaoka Y, Azuma S, Watanabe M
- Journal Title
  
  Hepatology
  
  Volume: 50 Pages: 1727-1737
- Data Source
  KAKENHI-PROJECT-21390226
[Journal Article] Bioactivity-guided screening identifies pheophytin a as a potent anti-hepatitis C virus compound from Lonicera hypoglauca Miq2009
- Author(s)
  Wang SY, Tseng CP, Tsai KC, Lin CF, Wen CY, Tsay HS, Sakamoto N, Tseng CH, Cheng JC
- Journal Title
  
  Biochem BiophysRes Commun
  
  Volume: 385 Pages: 230-235
- Data Source
  KAKENHI-PROJECT-21390226
[Journal Article] Two flavonoids extracts from a herb, Glycyrrhizae radix, inhibit in-vitro hepatitis C virus replication.2009
- Author(s)
  Sekine-Osajima Y, Sakamoto N, Nakagawa M, Itsui Y, Tasaka M, Nishimura-Sakurai Y, Chen CH, Suda G, Mishima K, Onuki Y, Yamamoto M, Maekawa S, Enomoto N, Kanai T, Tsuchiya K, Watanabe M
- Journal Title
  
  Hepatoloj Res 39
  
  Pages: 60-69
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390196
[Journal Article] Two flavonoids extracts from Glycyrrhizae radix inhibit in vitro hepatitis C virus replication.2009
- Author(s)
  Sekine-Osajima Y, ChenCH., et al.
- Journal Title
  
  Hepatology Research 39
  
  Pages: 60-69
- NAID
  10025324061
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590752
[Journal Article] Two flavonoidsextracts from Glycyrrhizae radix inhibit in vitrohepatitis C virus replication2009
- Author(s)
  Sekine-Osajima Y, Sakamoto N, Nakagawa M, Itsui Y, Tasaka M, Nishimura-Sakurai Y, Chen CH, Suda G, Mishima K, Onuki Y, Yamamoto M, Maekawa S, Enomoto N, Kanai T, Tsuchiya K and Watanabe M
- Journal Title
  
  Hepatol Res 39
  
  Pages: 60-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590752
[Journal Article] Inhibition of hepatitis C virus infection and expression in vitro and in vivo by recombinant adenovirus expressing short hairpin RNA.2008
- Author(s)
  Sakamoto N, Tanabe Y, Yokota T, Saito K, Sekine-Osajima Y, Nakagawa M, Itsui Y, Tasaka M, Sakurai Y, Chen CH, Yano M, Ohkoshi S, Aoyagi Y, Maekawa S, Enomoto N, Kohara M, Watanabe M
- Journal Title
  
  J Gastro Hepatol 23
  
  Pages: 1437-1447
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390196
[Journal Article] Two flavonoids extracts from a herb, Glycyrrhizae radix, inhibit in-vitrohepatitis C virus replication.2008
- Author(s)
  Sakamoto N, Sekine-Osajima Y, Nakagawa M, Itsui Y, Chen CH, Watanabe M, et. al.
- Journal Title
  
  Hepatology Research (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390196
[Journal Article] Inhibition of hepatitis C virus infection and expression in vitro and in vivo by recombinant adenovirus expressing short hairpin RNA.2008
- Author(s)
  Sakamoto N, Chen CH, Watanabe M, et. al.
- Journal Title
  
  Journal of Gastroenterology and Hepatology (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590752
[Journal Article] Inhibition of hepatitis C virus infection and expression in vitro and in vivo by recombinant adenovirus expressing short hairpin RNA2008
- Author(s)
  Sakamoto N, Tanabe Y, Yokota T, Saito K,Sekine-Osajima Y, Nakagawa M, Itsui Y,Tasaka M, Sakurai Y, Chen CH, Yano M,Ohkoshi S, Aoyagi Y, Maekawa S, Enomoto N, Kohara M, Watanabe M
- Journal Title
  
  J Gastro Hepatol 23(9)
  
  Pages: 1437-1447
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390196
[Journal Article] Development of plaque assays for hepatitis C virus and isolation of mutants with enhanced cytopathogenicity and replication capacity.2008
- Author(s)
  Sekine-Osajima Y, Sakamoto N (equal contribution), Nakagawa M, Itsui Y, Tasaka M, Nishimura-Sakurai Y, Chen CH, Kanai T, Tsuchiya K, Wakita T, Enomoto N, Watanabe M
- Journal Title
  
  Virology 368
  
  Pages: 71-85
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390196
[Journal Article] Development of plaque assays for hepatitis C virus-JFH1 strain and isolation of mutants with enhanced cytopathogenicity and replication capacity.2008
- Author(s)
  Sekine-Osajima Y, Sakamoto N, Chen CH, Watanabe M, et. al.
- Journal Title
  
  Virology 371
  
  Pages: 71-85
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590752
[Journal Article] Development of plaque assays forhepatitis C virus-JFH1 strain and isolation ofmutants with enhanced cytopathogenicity and replication capacity2008
- Author(s)
  Sekine-Osajima Y, Sakamoto N, MishimaK, Nakagawa M, Itsui Y, Tasaka M,Nishimura-Sakurai Y, Chen CH, Kanai T, Tsuchiya K, Wakita T, Enomoto N and Watanabe M
- Journal Title
  
  Virology 371
  
  Pages: 71-85
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590752
[Journal Article] Development of plaque assaysfor hepatitis C virus and isolation of mutantswith enhanced cytopathogenicity and replication capacity2008
- Author(s)
  Sekine-Osajima Y, Sakamoto N(equal contribution), Nakagawa M, Itsui Y, TasakaM, Nishimura-Sakurai Y, Chen CH, Kanai T,Tsuchiya K, Wakita T, Enomoto N and Watanabe M
- Journal Title
  
  Virology 371
  
  Pages: 71-85
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390196
[Journal Article] Hepatitis C virus non-structural proteins responsible for suppression of the RIG-I/Cardif-induced interferon response2007
- Author(s)
  Tasaka M, Sakamoto N, Itakura Y,Nakagawa M, Itsui Y, Sekine-Osajima Y,Nishimura-Sakurai Y, Chen CH, Yoneyama M,Fujita T, Wakita T, Maekawa S, Enomoto N and Watanabe M
- Journal Title
  
  J Gen Virol 88
  
  Pages: 3323-33
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590752
[Journal Article] HCV nonstructural proteins responsible for suppression of RIG-I/Cardif-induced interferon response2007
- Author(s)
  Tasaka M, Sakamoto N(equal contribution), Itakura Y, Nakagawa M, Itusi Y,Sekine-Osajima Y, Nishimura-Sakurai Y,Chen CH, Yoneyama M, Fujita T, Wakita T,Maekawa S, Enomoto N, Watanabe M
- Journal Title
  
  J Gen Virol 88
  
  Pages: 3323-3333
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390196
[Journal Article] Inhibition of hepatitis C virus infection and expression in vitro and in vivo by recombinant adenovirus expressing short hairpin RNA2007
- Author(s)
  Sakamoto N, Tanabe Y, Yokota T, Satoh K, Sekine-Osajima Y, Nakagawa M, Itsui Y, Tasaka M, Sakurai Y, Chen CH, Yano M, Ohkoshi S,Aoyagi Y, Maekawa S, Enomoto N, Kohara M and Watanabe M
- Journal Title
  
  J Gastroenterol Hepatol
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590752
[Journal Article] Hepatitis C virus non-structural proteins responsible for suppression of the RIG-I/Cardif-induced interferon response.2007
- Author(s)
  Tasaka M, Sakamoto N, Chen CH, Watanabe M, et. al.
- Journal Title
  
  Journal of General Virology 88
  
  Pages: 3323-3333
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590752
[Journal Article] Site-specific mutation of the interferon sensitivity-determining region (ISDR) modulates hepatitis C virus replication.2006
- Author(s)
  Kohashi T, Sakamoto N, Chen CH, Kakinuma S, Watanabe M, et al.
- Journal Title
  
  Journal of Viral Hepatitis. 13・9
  
  Pages: 582-590
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590625
[Journal Article] Negative regulation of intracellular hepatitis C virus replication by interferon regulatory factor 3.2006
- Author(s)
  Yamashiro T, Sakamoto N, Chen CH, Watanabe M, et al.
- Journal Title
  
  Journal of Gastroenterology. 41・8
  
  Pages: 750-757
- NAID
  10018255879
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590625
[Journal Article] Negative regulation of intracellular hepatitis C virus replication by interferon regulatory factor 3.2006
- Author(s)
  Yamashiro T, Sakamoto N, Chen CH, Watanabe M, et al.
- Journal Title
  
  Journal of Gastroenterology 41・8
  
  Pages: 750-757
- NAID
  10018255879
- Data Source
  KAKENHI-PROJECT-17590625
[Journal Article] Negative regulation of intracellular hepatitis C virus replication by interferon regulatory factor 3.2006
- Author(s)
  Yamashito T, Sakamoto N, Chen CH, Watanabe M, et al.
- Journal Title
  
  Journal of Gastroenterology 41(8)
  
  Pages: 750-757
- NAID
  10018255879
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590625
[Journal Article] Site-specific mutation of the interferon sensitivity-determining region (ISDR) modulates hepatitis C virus replication.2006
- Author(s)
  Kohashi T, Sakamoto N, Chen CH, Kakinuma S, Watanabe M, et al.
- Journal Title
  
  Journal of Viral Hepatitis 13・9
  
  Pages: 582-590
- Data Source
  KAKENHI-PROJECT-17590625
[Journal Article] Site-specific mutation of the interferon sensitivity-determining region (ISDR) modulates hepatitis C virus replication.2006
- Author(s)
  Kohashi T, Sakamoto N, Chen CH, Kakinuma S, Watanabe M, et al.
- Journal Title
  
  Journal of Viral Hepatitis 13(9)
  
  Pages: 582-590
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590625
[Journal Article] Enhancement of mitochondrial gene expression in the liver of primary biliary cirrhosis.2005
- Author(s)
  Chen CH, Sakamoto N, Kakinuma S, Watanabe M, et al.
- Journal Title
  
  Hepatology Research 31(1)
  
  Pages: 24-30
- NAID
  10015455952
- Data Source
  KAKENHI-PROJECT-17590625
[Journal Article] Suppression of hepatitis C virus replication by cyclosporin A is mediated by blockade of cyclophilins.2005
- Author(s)
  Nakagawa M, Sakamoto N, Chen CH, Kakinuma S, Watanabe M, et al.
- Journal Title
  
  Gastroenterology. 129・3
  
  Pages: 1031-1041
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590625
[Journal Article] Suppression of hepatitis C virus replication by cyclosporin A is mediated by blockade of cyclophilins.2005
- Author(s)
  Nakagawa M, Sakamoto N, Chen CH, Kakinuma S, Watanabe M et al.
- Journal Title
  
  Gastroenterology 129(3)
  
  Pages: 1031-1041
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590625
[Journal Article] Suppression of hepatitis C virus replication by cycosporin A is mediated by blockade of cyclophilins.2005
- Author(s)
  Nakagawa M, Sakamoto N, Chen CH, Kakinuma S, Watanabe M, et al.
- Journal Title
  
  Gastroenterology 129(3)
  
  Pages: 1031-1041
- Data Source
  KAKENHI-PROJECT-17590625
[Journal Article] Studies on virus kinetics using infectious fluorescence-tagged hepatitis C virus cell culture
- Author(s)
  Yamamoto M, Sakamoto N, Nakamura T, Itsui Y, Nakagawa M, Nishimura-Sakurai Y, Kakinuma S, Azuma S, Kato T, Wakita T, Watanabe M
- Journal Title
  
  Hepatol Res
- Data Source
  KAKENHI-PROJECT-21590833
[Presentation] ヒトiPS細胞培養系を利用したB型肝炎ウイルスゲノム組み込みによる発癌プロセスの解析2021
- Author(s)
  土屋淳、三好正人、紙谷聡英、志水太郎、新田沙由梨、北畑富貴子、渡壁慶也、持田知洋、村川美也子、中川美奈、東正新、朝比奈靖浩、朝比奈靖浩、岡本隆一、柿沼晴
- Organizer
  第28回肝細胞研究会
- Data Source
  KAKENHI-PROJECT-21K07909
[Presentation] Factors associated with HCC development and patients’ survival in patients with an SVR2021
- Author(s)
  Mina Nakagawa, Masato Miyoshi, Fukiko Kawai-Kitahata, Miyako Murakawa, Sayuri Nitta, Yasuhiro Itsui, Seishin Azuma, Sei Kakinuma, Yasuhiro Asahina.
- Organizer
  JSH International Liver Conference 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07909
[Presentation] ヒトiPS細胞由来肝臓構成細胞による肝線維症の病態解析2021
- Author(s)
  柿沼　晴、三好正人、紙谷聡英、土屋淳、志水太郎、新田沙由梨、村川美也子、北畑富貴子、東正新、中川美奈、朝比奈靖浩、岡本隆一.
- Organizer
  第20回日本再生医療学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07964
[Presentation] 肝間葉系細胞によるvasoactive intestinal peptideを介した胆管形成調節機構.2020
- Author(s)
  柿沼　晴、佐藤綾子、三好正人、紙谷聡英、土屋　淳、志水太郎、北畑富貴子、村川美也子、新田沙由梨、井津井康浩、中川美奈、東　正新、朝比奈靖浩、渡辺　守.
- Organizer
  第27回肝細胞研究会
- Data Source
  KAKENHI-PROJECT-18K07964
[Presentation] Poor improvement of on-treatment FIB-4 index after initiation of nucleos(t)ide analogs is associated with development of hepatocellular carcinoma in both cirrhotic and non-cirrhotic chronic hepatitis B patients.2020
- Author(s)
  Miyako Murakawa, Taro Shimizu, Eiko Takeichi, Jun Tsuchiya, Ayako Sato, Masato Miyoshi, Fukiko Kawai-Kitahata, Sayuri Nitta, Yasuhiro Itsui, Mina Nakagawa, Seishin Azuma, Sei Kakinuma, Yasuhiro Asahina.
- Organizer
  EASL The Digital International Liver Congress 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07964
[Presentation] Comprehensive analysis of cancer-related genes and AAV/hepatitis B virus integration into genome on development of hepatocellular carcinoma in patients with prior hepatitis B virus infection.2020
- Author(s)
  Fukiko Kawai-Kitahata, Yasuhiro Asahina , Sei Kakinuma, Miyako Murakawa, Sayuri Nitta, Masato Miyoshi, Ayako Sato, Jun Tsuchiya, Taro Shimizu, Eiko Takeichi, Mina Nakagawa, Yasuhiro Itsui, Seishin Azuma, Shinji Tanaka , Minoru Tanabe, Shinya Maekawa, Nobuyuki Enomoto and Mamoru Watanabe.
- Organizer
  EASL The Digital International Liver Congress 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07964
[Presentation] Vasoactive intestinal peptideの肝内胆管形成および胆汁うっ滞性肝障害への寄与.2020
- Author(s)
  佐藤綾子、柿沼　晴、志水太郎、土屋　淳、三好正人、北畑富貴子、村川美也子、新田沙由梨、井津井康浩、中川美奈、東　正新、朝比奈靖浩.
- Organizer
  第24回日本肝臓学会大会
- Data Source
  KAKENHI-PROJECT-18K07964
[Presentation] Vasoactive intestinal peptide による胆管形成調節の分子機序2019
- Author(s)
  佐藤綾子、柿沼晴、土屋淳、三好正人、角田知之、井津井康浩、中川美奈、東正新、朝比奈靖浩、渡辺守.
- Organizer
  第26回肝細胞研究会
- Data Source
  KAKENHI-PROJECT-18K07964
[Presentation] Comprehensive analysis of cancer gene mutations and viral integration in hepatocellular carcinoma arising from non-fibrotic liver2019
- Author(s)
  Asahina Y, Kawai-Kitahata F, Murakawa M, Nitta S, Itsui Y, Nakagawa M, Azuma S, Kakinuma S.
- Organizer
  The 70th Annual Meeting of the American Association for the Study of Liver Disease
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07964
[Presentation] 背景肝の線維化からみた肝細胞がんにおけるがん関連遺伝子変異と viral integration の解析.2019
- Author(s)
  北畑富貴子、朝比奈靖浩、村川美也子、新田沙由梨、柿沼晴、角田知之、三好正人、四宮恵美、佐藤綾子、土屋淳、井津井康浩、中川美奈、東正新、田中真二、田邉稔、前川伸哉、榎本信幸、渡辺守.
- Organizer
  第55回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-18K07964
[Presentation] The association of serum IFN-λ3 levels with liver fibrosis and hepatocarcinogenesis in chronic hepatitis C patients treated with direct-acting antiviral agents.2019
- Author(s)
  Murakawa M, Inoue-Shinomiya E, Asahina Y, Nakagawa M, Tsuchiya J, Sato A, Miyoshi M, Tsunoda T, Kawai-Kitahata F, Nitta S, Itsui Y, Kakinuma S, Azuma S, Watanabe M.
- Organizer
  The 54th annual meeting of the European association for the study of the liver
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07964
[Presentation] ヒト iPS 細胞による疾患モデルを利用した先天性肝線維症分子標的の探索2019
- Author(s)
  柿沼晴、角田知之、三好正人、紙谷聡英、佐藤綾子、土屋淳、北畑富貴子、村川美也子、新田沙由梨、井津井康浩、中川美奈、東正新、朝比奈靖浩、渡辺守
- Organizer
  JDDW2019
- Data Source
  KAKENHI-PROJECT-18K07964
[Presentation] NAFLD由来の肝細胞癌に関連したリスク因子の検討2018
- Author(s)
  東　正新、朝比奈靖浩、三好正人、井上恵美、角田知之、佐藤綾子、金子　俊、永田紘子、北畑富貴子、村川美也子、新田沙由梨、井津井康浩、中川美奈、柿沼　晴、渡辺　守
- Organizer
  JDDW2019
- Data Source
  KAKENHI-PROJECT-18K07964
[Presentation] Post-Treatment M2BPGi Level Is Useful for Predicting HCC Occurrence and Recurrence after Viral Eradication in Chronic Hepatitis C Patients2018
- Author(s)
  Nakagawa M, Asahina Y, Kawai-Kitahata F, Murakawa M, Nitta S, Itsui Y, Azuma S, Kakinuma S, Tomita M, Watanabe M.
- Organizer
  AASLD The Liver Meeting 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07964
[Presentation] 肝前駆細胞による胆管形成に対する胎生期肝間葉系細胞との細胞間相互作用2018
- Author(s)
  佐藤綾子、柿沼　晴、東　正新、三好正人、角田知之、金子　俊、井津井康浩、朝比奈靖浩、渡辺　守
- Organizer
  第25回肝細胞研究会
- Data Source
  KAKENHI-PROJECT-18K07964
[Presentation] NAFLD における肝細胞癌リスク因子についての検討2018
- Author(s)
  東　正新、朝比奈靖浩、渡辺　守
- Organizer
  第54回日本肝癌研究会
- Data Source
  KAKENHI-PROJECT-18K07964
[Presentation] ヒトiPS 細胞由来星細胞様細胞における転写因子LHX2 の機能解析.2018
- Author(s)
  三好正人、柿沼晴、東正新、金子俊、紙谷聡英、佐藤綾子、角田知之、四宮恵美、北畑富貴子、新田沙由梨、村川美也子、井津井康浩、中川美奈、朝比奈靖浩、渡辺　守.
- Organizer
  第54回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-18K07964
[Presentation] A novel culture model for coinfection of hepatitis B and hepatitis C viruses using human induced pluripotent stem cell-derived hepatic cells for analyses of changes in host-innate immune responses2017
- Author(s)
  Kaneko S, Kakinuma S, Asahina Y, Azuma S, Watanabe M, et al.
- Organizer
  AASLD The Liver Meeting 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08989
[Presentation] NAFLD由来肝細胞癌の囲い込みにおける糖尿病性網膜症診断の有用性2017
- Author(s)
  東　正新、朝比奈靖浩、渡辺　守
- Organizer
  第53回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-15K08989
[Presentation] LHX2発現によるヒトiPS 由来間葉系細胞の機能調節2017
- Author(s)
  三好正人、柿沼　晴、東　正新、朝比奈靖浩、渡辺　守、他
- Organizer
  第24回肝細胞研究会
- Data Source
  KAKENHI-PROJECT-15K08989
[Presentation] Genetic differences in hepatocellular carcinoma among chronic persistent hepatitis B virus infection with or without viral suppression and prior hepatitis B virus infection2017
- Author(s)
  Kawai-Kitahata F, Asahina Y, Kakinuma S, Azuma S, Watanabe M, et al.
- Organizer
  EASL The International Liver Congress 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08989
[Presentation] Diabetic retinopathy as a risk factor associated with development of hepatocellular carcinoma in non-alcoholic fatty liver disease2017
- Author(s)
  Azuma S, Asahina Y, Kakinuma S, Azuma K, Watanabe M
- Organizer
  APDW2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08989
[Presentation] ヒトiPS細胞由来肝臓系譜細胞による病態モデルの作成と先天性肝線維症の病態解析2017
- Author(s)
  角田知之、柿沼　晴、東　正新、朝比奈靖浩、渡辺　守、他
- Organizer
  第54回日本消化器免疫学会総会
- Data Source
  KAKENHI-PROJECT-15K08989
[Presentation] BMP-4 による肝幹/前駆細胞の増殖と終末分化の制御機構2016
- Author(s)
  柿沼晴、後藤文男、大谷賢志、角田知之、三好正人、東正新、金子俊、浅野侑、永田紘子、北畑富貴子、村川美也子、新田沙由梨、井津井康浩、中川美奈、朝比奈靖浩、渡辺守.
- Organizer
  JDDW2016（第24回日本消化器関連学会週間）
- Place of Presentation
  神戸コンベンションセンター（兵庫県神戸市）
- Data Source
  KAKENHI-PROJECT-15K08989
[Presentation] Intermediate HCCに対する治療戦略2016
- Author(s)
  東正新、朝比奈靖浩、櫻井幸、井津井康浩、三好正人、井上恵美、浅野侑、金子俊、永田紘子、後藤文男、大谷賢志、北畑富貴子、新田沙由梨、村川美也子、中川美奈、柿沼晴、渡辺守.
- Organizer
  第102回日本消化器病学会総会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Data Source
  KAKENHI-PROJECT-15K08989
[Presentation] A new model for studying interaction between hepatitis B virus and host cells derived from human induced pluripotent stem cells.2016
- Author(s)
  Kaneko S, Kakinuma S, Asahina Y, Kamiya A, Nitta S, Tsunoda T, Miyoshi M, Asano Y, Nagata H , Goto F, Otani S, Kitahata F, Murakawa M, Itsui Y, Nakagawa M, Azuma S, Watanabe M.
- Organizer
  EASL, The International Liver Congress 2016
- Place of Presentation
  Barcelona（Spain）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08989
[Presentation] 肝幹/前駆細胞におけるBone Morphogenetic Protein-4 の機能解析2016
- Author(s)
  後藤文男、柿沼晴、大谷賢志、角田知之、三好正人、浅野侑、金子俊、井津井靖浩、中川美奈、東正新、朝比奈靖浩、渡辺守.
- Organizer
  第52回日本肝臓学会総会
- Place of Presentation
  ホテルニューオータニ幕張（千葉県千葉市）
- Data Source
  KAKENHI-PROJECT-15K08989
[Presentation] 2015265372 Intermediate stage以後および肝機能不良の肝癌の治療選択と予後: Intermediate HCCに対する局所治療併用効果の検討2015
- Author(s)
  東正新, 朝比奈靖浩, 渡辺守
- Organizer
  第51回日本肝臓学会総会
- Place of Presentation
  ホテル日航熊本（熊本県熊本市）
- Year and Date
  2015-05-22
- Data Source
  KAKENHI-PROJECT-15K08989
[Presentation] Gene alterations in tert promoter, CTNNB1, and TP53 are closely associated with development and prognosis of hepatocellular carcinoma: comprehensive analyses by next generation sequencing technology.2015
- Author(s)
  Asahina Y, Kawai-Kitahata F, Kaneko S, Nagata H, Goto F, Otani S, Taniguchi M, Murakawa M, Nitta S, Watanabe T, Tasaka-Fujita M, Nishimura-Sakurai Y, Itsui Y, Nakagawa M, Azuma S, Kakinuma S, Tanaka S, Tanabe M, Enomoto N, Watanabe M.
- Organizer
  European Association of the Study of Liver Disease, 50th The International liver congress
- Place of Presentation
  Vienna (Austria)
- Year and Date
  2015-04-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08989
[Presentation] 肝幹/前駆細胞におけるMatrix Metalloproteinase-14による分化調節機構の解析2015
- Author(s)
  大谷賢志, 柿沼晴, 後藤文男, 紙谷聡英, 櫻井幸, 井津井康浩, 東正新, 中川美奈, 朝比奈靖浩, 坂本直哉, 中内啓光, 渡辺守
- Organizer
  第51回日本肝臓学会総会
- Place of Presentation
  ホテル日航熊本（熊本県熊本市）
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-15K08989
[Presentation] Human induced pluripotent stem cell-derived hepatic progenitor-like cells and hepatocyte-like cells as a model for interaction between hepatitis B virus and host cells.2015
- Author(s)
  Kaneko S, Kakinuma S, Asahina Y, Kamiya A, Nitta S, Tsunoda T, Miyoshi M, Nagata H, Goto F, Otani S, Murakawa M, Kawai-Kitahata F, Itsui Y, Nakagawa M, Azuma S, Watanabe M.
- Organizer
  American Association for the Study of Liver Diseases, The Liver Meeting 2015
- Place of Presentation
  San Francisco (USA)
- Year and Date
  2015-11-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08989
[Presentation] 肝細胞癌診断における拡散強調画像の有用性2013
- Author(s)
  東正新、朝比奈靖浩、渡辺守
- Organizer
  第49回日本肝臓学会総会
- Place of Presentation
  東京（京王プラザホテル）
- Data Source
  KAKENHI-PROJECT-24590959
[Presentation] Wnt5a-CaMK2経路による肝幹/前駆細胞の胆管分化の調節機構2013
- Author(s)
  柿沼晴、幾世橋佳、山中秀人、紙谷聡英、新田沙由梨、藤木純子、吉野耕平、中川美奈、東正新、坂本直哉、朝比奈靖浩、中内啓光、渡辺守
- Organizer
  第49回日本肝臓学会総会
- Place of Presentation
  東京（京王プラザホテル）
- Data Source
  KAKENHI-PROJECT-24590959
[Presentation] Impaired IL28B gene induction and expression of IFNγ4 are closely associated with a non-response to interferon-based therapy in chronic hepatitis C patients2013
- Author(s)
  Asahina Y, Murakawa M, Nitta S, Itsui Y, Nakagawa M, Azuma S, Kakinuma S, Watanabe M
- Organizer
  The 64rd Annual Meeting of the American Association for the Study of Liver Disease (AASLD The Liver Meeting 2013)
- Place of Presentation
  ワシントン(USA)
- Data Source
  KAKENHI-PROJECT-24590959
[Presentation] 肝細胞癌診断におけるMRI拡散強調画像の有用性の検討2013
- Author(s)
  東正新、朝比奈靖浩、後藤文男、大谷賢志、谷口未樹、河合富貴子、藤木純子、村川美也子、小野塚泉、新田沙由梨、北詰晶子、櫻井幸、中川美奈、柿沼晴、渡辺守
- Organizer
  JDDW 2013 第17回日本肝臓学会大会
- Place of Presentation
  東京（グランドプリンスホテル新高輪）
- Data Source
  KAKENHI-PROJECT-24590959
[Presentation] Wnt5a-CaMK2経路による肝幹/前駆細胞の分化調節機構2013
- Author(s)
  柿沼晴、幾世橋佳、紙谷聡英、新田沙由梨、東正新、中川美奈、朝比奈靖浩、坂本直哉、中内啓光、渡辺守
- Organizer
  JDDW 2013 第17回日本肝臓学会大会
- Place of Presentation
  東京（グランドプリンスホテル新高輪）
- Data Source
  KAKENHI-PROJECT-24590959
[Presentation] Treatment and outcomes for elderly patients with hepatocellular caricinoma2012
- Author(s)
  Azuma S, Sakamoto N, Kakinuma S, Watanabe M, et al
- Organizer
  The 22nd Conference of the Asian Pacific Association for the Study of the Liver
- Place of Presentation
  Taipei,台湾
- Year and Date
  2012-02-17
- Data Source
  KAKENHI-PROJECT-21590833
[Presentation] Imparied IL28B gene induction and poor IL28B promoter activity influenced by the IL28B minor allele are closely associated with a null response to interferon in chronic hepatitis C patients.2012
- Author(s)
  Asahina Y, Sakamoto N, Azuma S, Watanabe M et al
- Organizer
  AASLD The Liver Meeting 2012
- Place of Presentation
  Boston
- Data Source
  KAKENHI-PROJECT-21590831
[Presentation] HCVNS4B蛋白はSTINGを介しRIG-I誘導性 Interferon産生応答を抑制する2012
- Author(s)
  新田沙由梨、坂本直哉、吉野耕平、村川美也子、北詰晶子、幾世橋佳、東正新、柿沼晴、中川美奈、朝比奈靖浩、渡辺守
- Organizer
  第48回肝臓学会総会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-21590831
[Presentation] HCV NS4B蛋白によるRIG-I誘導性Interferon発現経路の抑制機構についての解析2012
- Author(s)
  新田沙由梨、坂本直哉、吉野耕平、村川美也子、北詰晶子、幾世橋佳、東正新、柿沼晴、中川美奈、朝比奈靖浩、渡辺守
- Organizer
  JDDW2012
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21590831
[Presentation] Treatment and outcomes for elderly patientswith hepatocellular caricinoma2012
- Author(s)
  Azuma S, Sakamoto N, Sakurai Y, Nakagawa M, Kakinuma S, Watanabe M
- Organizer
  22nd Conference of the Asian Pacific Association for the Study of the Liver, Feb-18-2012, Taipei, Taiwan
- Place of Presentation
  Taipei, Taiwan
- Year and Date
  2012-02-18
- Data Source
  KAKENHI-PROJECT-21590833
[Presentation] IFN不応例における宿主自然免疫応答とHCV逃避機構2012
- Author(s)
  新田沙由梨,朝比奈靖浩,坂本直哉,村川美也子,北詰晶子,幾世橋佳,東正新,柿沼晴,中川美奈,渡辺守
- Organizer
  第77回日本インターフェロン・サイトカイン学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21590831
[Presentation] Antiviral effects and action mechanisms of novel N-(morpholine-4-carbonyloxy) amidine compaunds against hepatitis C virus.2012
- Author(s)
  Kusano-Kitazume A, Sakamoto N, Azuma S, Asahina Y, Watanabe M et al
- Organizer
  AASLD The Liver Meeting 2012
- Place of Presentation
  Boston
- Data Source
  KAKENHI-PROJECT-21590831
[Presentation] ITPA gene variant protects against treatment-induced anemia and improves viral clearance by pegylated interferon-alfa and ribavirin therapy in chronic hepatitis C patients2011
- Author(s)
  Sakamoto N, Azuma S, Watanabe M, et al
- Organizer
  62th. Annual Meeting of American Association for the Study of Liver Diseases
- Place of Presentation
  San Francisco
- Year and Date
  2011-11-04
- Data Source
  KAKENHI-PROJECT-21590832
[Presentation] IL-6-mediated intersubgenotypic variation of interferon sensitivity in hepatitis C virus genotype 2a/2b chimeric clones2011
- Author(s)
  Suda G, Sakamoto N, Nakagawa M, Azuma S, Watanabe M, et al.
- Organizer
  62th. Annual Meeting of American Association for the Study of Liver Diseases
- Place of Presentation
  San Francisco
- Year and Date
  2011-11-04
- Data Source
  KAKENHI-PROJECT-21390226
[Presentation] HCV-NS4B蛋白とIFN発現シグナル分子との分子間相互作用の解析2011
- Author(s)
  新田沙由梨、坂本直哉、藤田めぐみ、北詰晶子、幾世橋佳、船岡祐介、渡辺貴子、植山真由美、小野塚泉、東正新、中川美奈、柿沼晴、渡辺守
- Organizer
  第48回日本消化器免疫学会
- Place of Presentation
  金沢
- Year and Date
  2011-07-21
- Data Source
  KAKENHI-PROJECT-21590831
[Presentation] ITPA gene variant protects against treatment-induced anemia and improves viral clearance by pegylated interferon-alfa and ribavirin therapy in chronic henatitis C patients2011
- Author(s)
  Sakamoto N, Nakagawa M, Azuma S, Watanabe M, et al.
- Organizer
  62th. Annual Meeting of American Association for the Study of Liver Diseases
- Place of Presentation
  San Francisco
- Year and Date
  2011-11-04
- Data Source
  KAKENHI-PROJECT-21390226
[Presentation] ITPA gene variant protects against treatment-induced anemia and improves viral clearance by pegylated interferon-alfa and ribavirin therapy in chronic hepatitis C patients2011
- Author(s)
  Sakamoto N, Azuma S, et al
- Organizer
  62th. Annual Meeting of American Association for the Study of Liver Diseases
- Place of Presentation
  San Francisco
- Year and Date
  2011-11-04
- Data Source
  KAKENHI-PROJECT-21590831
[Presentation] HCV-NS4B蛋白とRIG-I惹起性IFN産生シグナル関連蛋白との分子間相互作用の解析2011
- Author(s)
  新田沙由梨、坂本直哉、藤田めぐみ、柿沼晴、村川美也子、北詰晶子、幾世橋佳、船岡祐介、渡辺貴子、植山真由美、小野塚泉、櫻井幸、中川美奈、東正新、渡辺守
- Organizer
  第47回日本肝臓学会総会
- Place of Presentation
  東京
- Year and Date
  2011-06-02
- Data Source
  KAKENHI-PROJECT-21590831
[Presentation] 高齢者肝細胞癌患者に対する治療方法とその成績2011
- Author(s)
  東正新、坂本直哉、桜井幸、吉野耕平、幾世橋佳、新田沙由梨、北詰晶子、村川美也子、中川美奈、柿沼晴、渡辺守
- Organizer
  JDDW 2011(第15回日本肝臓学会大会)
- Place of Presentation
  福岡
- Year and Date
  2011-10-20
- Data Source
  KAKENHI-PROJECT-21590833
[Presentation] IL-6-mediated intersubgenotypic variation of interferon sensitivity in hepatitis C virus genotype 2a/2b chimeric clones2011
- Author(s)
  Suda G, Sakamoto N, Itsui Y, Nakagawa M, Tasaka-Fujita M, Funaoka Y, Watanabe T, Nitta S, Kiyohashi K, Azuma S, Kakinuma S, Tsuchiya K, Imamura M, Hiraga N, Chayama K, Watanabe M
- Organizer
  62th. Annual Meeting of American Association for the Study of Liver Diseases
- Place of Presentation
  San Francisco
- Year and Date
  2011-11-04
- Data Source
  KAKENHI-PROJECT-21590831
[Presentation] 肝線維化プロセスにおけるMatrixMetalloproteinase-2の機能2011
- Author(s)
  柿沼晴、紙谷聡英、小野塚泉、東正新、坂本直哉、中内啓光、渡辺守
- Organizer
  第15回日本肝臓学会大会
- Place of Presentation
  福岡
- Year and Date
  2011-10-20
- Data Source
  KAKENHI-PROJECT-21590833
[Presentation] ITPA gene variant protects against treatment-induced anemia and improves viral clearance by pegylated interferon-alfa and ribavirin therapy in chronic hepatitis C patients2011
- Author(s)
  Sakamoto N, Tanaka Y, Nakagawa M, Yatsuhashi H, Nishiguchi S, Enomoto N, Azuma S, Nishimura-Sakurai Y, Kakinuma S, Nishida N, Tokunaga K, Mizokami M, Watanabe M
- Organizer
  62 nd Annual Meeting of American Association for the Study of Liver Diseases
- Place of Presentation
  San Francisco, CA. USA
- Year and Date
  2011-11-05
- Data Source
  KAKENHI-PROJECT-21590833
[Presentation] IL-6-mediated intersubgenotypic variation of interferon sensitivity in hepatitis C virus genotype 2a/2b chimeric clones2011
- Author(s)
  Suda G, Sakamoto N, Azuma S, Watanabe M, et al
- Organizer
  62th. Annual Meeting of American Association for the study of Liver Diseases
- Place of Presentation
  San Francisco
- Year and Date
  2011-11-04
- Data Source
  KAKENHI-PROJECT-21590832
[Presentation] Identification of Novel Small Molecules Inhibitors of Hepatitis C Virus Replication Using a Cell-Based High-Throughput Screen2010
- Author(s)
  Akiko Kusano-Kitazume, Naoya Sakamoto, Yuko Sekine-Osajima, Seishin Azuma, Mina Nakagawa, Sei Kakinuma, Yuki Nishimura-Sakurai, Yukiko Okuno, Masatoshi Hagiwara, and Mamoru Watanabe
- Organizer
  17th. International Meeting on Hepatitis C Virus & Related Viruses
- Place of Presentation
  Yokohama, Japan
- Year and Date
  2010-09-09
- Data Source
  KAKENHI-PROJECT-21390226
[Presentation] 細胞障害性HCV-JFH1における遺伝子変異の機能解析とin vivo感染動態の検討2010
- Author(s)
  三島果子、坂本直哉、筬島裕子、中川美奈、柿沼晴、陳正新、脇田隆字、今村道雄、茶山一彰、渡辺守
- Organizer
  (一般口演)第46回日本肝臓学会総会
- Place of Presentation
  山形
- Year and Date
  2010-05-27
- Data Source
  KAKENHI-PROJECT-21590832
[Presentation] SR蛋白リン酸化酵素(SRPK)阻害剤によるHCV増殖抑制効果の解析(ワークシヨップ)2010
- Author(s)
  唐鎌優子、坂本直哉、小野木博、井津井康浩、中川美奈、柿沼晴、東正新、萩原正敏、渡辺守
- Organizer
  第46回日本肝臓学会総会
- Place of Presentation
  山形
- Year and Date
  2010-05-27
- Data Source
  KAKENHI-PROJECT-21390226
[Presentation] Genotype 2型C型慢性肝炎のインターフェロン治療再燃例に対する再治療の試み2009
- Author(s)
  渡辺貴子、中川美奈、船岡祐介、植山真由美、三島果子、山本満千、小貫優子、須田剛生、櫻井幸、田坂めぐみ、筬島裕子、井津井康浩、陳正新、坂本直哉、渡辺守
- Organizer
  第45回日本肝臓学会総会
- Place of Presentation
  神戸
- Year and Date
  2009-06-04
- Data Source
  KAKENHI-PROJECT-21590831
[Presentation] In-vitro replication and interferon sensitivity of core aa 70 and 91 mutant HCV cell culture2009
- Author(s)
  Yusuke Funaoka, Naoya Sakamoto, Goki Suda, Yasuhiro Itsui, Mina Nakagawa, Kako Mishima, Yuko Karakama, Machi Yamamoto, Cheng-Hsin Chen-Azuma, Sei Kakinuma and Mamoru Watanabe
- Organizer
  60th. Annual Meeting of American Association for the Study of Liver Diseases
- Place of Presentation
  Boston, MA
- Year and Date
  2009-10-30
- Data Source
  KAKENHI-PROJECT-21390226
[Presentation] HCVコア変異株培養系を用いたインターフェロン感受性、細胞内増殖、粒子分泌能の解析2009
- Author(s)
  船岡祐介、坂本直哉、井津井康浩、須田剛生、中川美奈、田坂めぐみ、櫻井幸、小貫優子、山本満千、渡辺貴子、植山真由美、陳正新、渡辺守
- Organizer
  第45回日本肝臓学会総会
- Place of Presentation
  神戸
- Year and Date
  2009-06-04
- Data Source
  KAKENHI-PROJECT-21590831
[Presentation] 造影CT、MRIが施行困難である症例に対する4D超音波によるラジオ波焼灼療法の治療評価の有効性の検討2009
- Author(s)
  幾世橋佳、東正新, 他
- Organizer
  第45回日本肝癌研究会
- Place of Presentation
  福岡
- Year and Date
  2009-07-03
- Data Source
  KAKENHI-PROJECT-21590833
[Presentation] Antiviral effects of interferon-induced proteins GBP-1 and its interactions with hepatitis C virusNS5B protein2009
- Author(s)
  Itsui Y, Sakamoto N, Nakagawa M, Osajima Y, Tasaka M, Sakurai Y, Suda G, Karakama Y, Mishima K, Yamamoto M, Watanabe T, Ueyama M, Funaoka Y, Azuma S (Chen CH), Kakinuma S, Yauchi T, Watanabe M
- Organizer
  60th. Annual Meeting of American Association for the Study of Liver Diseases
- Place of Presentation
  Boston
- Year and Date
  2009-11-02
- Data Source
  KAKENHI-PROJECT-21590831
[Presentation] RFA治療における4D超音波の有効性2009
- Author(s)
  東正新、坂本直哉, 他
- Organizer
  第45回日本肝癌研究会
- Place of Presentation
  福岡
- Year and Date
  2009-07-03
- Data Source
  KAKENHI-PROJECT-21590833
[Presentation] In-vitro and in-vivo Characterization of a new genotype 2b HCV clone and 2b/JFH1 intergenotypic chimera and analyses of the factor that regulate interferon sensitivity2009
- Author(s)
  Goki Suda, Naoya Sakamoto, Yasuhiro Itsui, Mina Nakagawa, Kako Mishima, Yuko Karakama, Machi Yamamoto, Cheng-Hsin Chen, Sei Kaki numa, KazuakiChayama, Michio Imamura and Mamoru Watanabe
- Organizer
  60th. Annual Meeting of American Association for the Study of Liver Diseases
- Place of Presentation
  Boston, MA
- Year and Date
  2009-10-30
- Data Source
  KAKENHI-PROJECT-21390226
[Presentation] Genotype 2b急性肝炎由来HCVクローンの構築と増殖・粒子形成能の解析2009
- Author(s)
  須田剛生、坂本直哉、中川美奈、田坂めぐみ、櫻井幸、小貫優子、山本満千、渡辺貴子、植山真由美、船岡祐介、井津井康浩、陳正新、今村道雄、茶山一彰、渡辺守
- Organizer
  第45回日本肝臓学会総会
- Place of Presentation
  神戸
- Year and Date
  2009-06-04
- Data Source
  KAKENHI-PROJECT-21590831
[Presentation] HCV複製増殖に関連する糖脂質代謝ネットワークの網羅的解析2009
- Author(s)
  櫻井幸、坂本直哉、中川美奈、井津井康浩、田坂めぐみ、小貫優子、須田剛生、三島果子、山本満千、植山真由美、船岡祐介、渡辺貴子、陳正新、渡辺守
- Organizer
  第45回日本肝臓学会総会
- Year and Date
  2009-06-04
- Data Source
  KAKENHI-PROJECT-21590831
[Presentation] Suppression of interferon induction and response pathway by Hepatitis C virus NS4B.2008
- Author(s)
  M. Tasakal, N. Sakamoto, M. Nakagawa, Y. Itsui, Y. Nishimura-Sakurai, C. Chen, Goki Suda, Kako Mishima, Machi Yamamoto, Yuko Onuki, M. Watanabe
- Organizer
  Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  San Francisco, CA, USA
- Year and Date
  2008-11-01
- Data Source
  KAKENHI-PROJECT-19390196
[Presentation] 3cmを超える肝細胞癌に対する当科の治療方法と成績2008
- Author(s)
  陳正新, 他
- Organizer
  第4 4回日本肝臓学会総会
- Place of Presentation
  愛媛県県民文化会蔀
- Year and Date
  2008-06-05
- Data Source
  KAKENHI-PROJECT-19590752
[Presentation] Pretreatment assessment of PEG-interferon plus ribavirin anti-HCV therapy using viral genetic profiles, NS5A-ISDR and Core mutations.2008
- Author(s)
  Naoya Sakamoto, Mina Nakagawa, Cheng-Hsin Chen, Yasuhiro Itsui, Megumi Tasaka, Nobuyuki Enomoto, Mamoru Watanabe
- Organizer
  Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  San Francisco, CA, USA
- Year and Date
  2008-11-01
- Data Source
  KAKENHI-PROJECT-19390196
[Presentation] Pretreatment assessment of PEG-interferon plus ribavirin anti-HCV therapy using viral genetic profiles, NS5A-ISDR and Core mutations2008
- Author(s)
  Naoya Sakamoto, Mina Nakagawa,Cheng-Hsin Chen, Yasuhiro Itsui, Megumi Tasaka, Nobuyuki Enomoto,and Mamoru Watanabe
- Organizer
  Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  San Francisco,CA
- Year and Date
  2008-11-01
- Data Source
  KAKENHI-PROJECT-19390196
[Presentation] 3cmを超える肝細胞癌に対する当科の治療方法と成績2008
- Author(s)
  陳正新、坂本直哉、井津井康浩、中川美奈、櫻井幸、須田剛生、山本満千、小貫優子、三島果子、渡辺守
- Organizer
  第44回日本肝臓学会総会
- Place of Presentation
  松山
- Year and Date
  2008-06-06
- Data Source
  KAKENHI-PROJECT-19590752
[Presentation] A novel NS5B-interacting protein modulates hepatitis C virus replication.2008
- Author(s)
  Jing-Tang Huang, Ching-Ping Tseng, Naoya Sakamoto, Shao-Chun Lu, Chuan-Mu Chen, Ju-Chien Cheng
- Organizer
  15th. International Meeting on Hepatitis C Virus & Related Viruses.
- Place of Presentation
  San Antonio, TX, USA
- Year and Date
  2008-10-04
- Data Source
  KAKENHI-PROJECT-19390196
[Presentation] A novel NS5B-interacting protein modulates hepatitis C virus replication2008
- Author(s)
  Jing-Tang Huang, Ching-Ping Tseng, Naoya Sakamoto, Shao-Chun Lu, Chuan-Mu Chen,Ju-Chien Cheng
- Organizer
  15th. International Meeting on Hepatitis C Virus & Related Viruses
- Place of Presentation
  San Antonio, TX
- Year and Date
  2008-10-04
- Data Source
  KAKENHI-PROJECT-19390196
[Presentation] Suppression of interferon induction and response pathway by Hepatitis C virus NS4B2008
- Author(s)
  M. Tasaka, N. Sakamoto, M. Nakagawa, Y.Itsui, Y. Nishimura-Sakurai, C. Chen, Goki Suda, Kako Mishima, Machi Yamamoto,Yuko Onuki, M. Watanabe
- Organizer
  Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  San Francisco,CA
- Year and Date
  2008-11-01
- Data Source
  KAKENHI-PROJECT-19390196
[Presentation] 当科における高齢肝細胞癌患者に対するラジオ波熱凝固療法の治療成績2007
- Author(s)
  陳正新、坂本直哉、渡辺守
- Organizer
  第43回日本肝臓学会総会
- Place of Presentation
  東京
- Year and Date
  2007-05-31
- Data Source
  KAKENHI-PROJECT-19590752
[Presentation] ラジオ波熱凝固療法における第二世代超音波造影剤の有用性2007
- Author(s)
  陳正新、坂本直哉、井津井康浩、中川美奈、筬島裕子、田坂めぐみ、櫻井幸、渡辺守
- Organizer
  JDDW2007(第10回日本肝臓学会大会)
- Place of Presentation
  神戸
- Year and Date
  2007-10-18
- Data Source
  KAKENHI-PROJECT-19590752
[Presentation] 肝幹/前駆細胞におけるCalmodulindependent protein kinase II 活性化動態の解析
- Author(s)
  後藤文男、柿沼　晴、大谷賢志、紙谷聡英、東　正新、朝比奈靖浩、渡辺　守
- Organizer
  第２１回肝細胞研究会
- Place of Presentation
  東京医科歯科大学（東京）
- Year and Date
  2014-06-27 – 2014-06-28
- Data Source
  KAKENHI-PROJECT-24590959
[Presentation] Matrix Metalloproteinase-14 regulates the maturation of fetal hepatic stem/progenitor cells in mice.
- Author(s)
  Otani S, Kakinuma S, Kamiya A, Goto F, Kaneko S, Azuma S, Asahina Y, Watanabe M
- Organizer
  The 65th Annual Meeting of American Association for the Study of Liver Diseases（AASLD The Liver Meeting 2014)
- Place of Presentation
  Boston (USA)
- Year and Date
  2014-11-08 – 2014-11-11
- Data Source
  KAKENHI-PROJECT-24590959
[Presentation] Antiviral effetcts and action mechanisms of novel N-(morpholine-4-carbonyloxy) amidine compounds against hepatitis C virus
- Author(s)
  Kusano-Kitazume A, Kakinuma S, Azuma S, Watanabe M, et al.
- Organizer
  63rd Annual Meeting of American Association for the Study of Liver Diseases
- Place of Presentation
  Boston
- Data Source
  KAKENHI-PROJECT-24590959
[Presentation] Intermediate HCC に対するIVR を併用したRFA 治療の意義の検討
- Author(s)
  東　正新、朝比奈靖浩、渡辺　守
- Organizer
  第５０回日本肝癌研究会
- Place of Presentation
  国立京都国際会館（京都）
- Year and Date
  2014-06-05 – 2014-06-06
- Data Source
  KAKENHI-PROJECT-24590959
[Presentation] Impaired IL28B gene induction and poor IL28B promoter activity influenced by the IL28B minor allele are closely associated with a null response to interferon in chronic hepatitis C patients.
- Author(s)
  Asahina Y, Kakinuma S, Azuma S, Watanabe M, et al.
- Organizer
  63rd Annual Meeting of American Association for the Study of Liver Diseases
- Place of Presentation
  Boston
- Data Source
  KAKENHI-PROJECT-24590959
[Presentation] EOB-MRIおよびAngio-CTによる多血性肝細胞癌に関する検討
- Author(s)
  東正新、柿沼晴、渡辺守、他
- Organizer
  第48回日本肝臓学会総会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-24590959
[Presentation] ４個以上の多発肝細胞癌に対するラジオ波熱焼灼術の適応と意義の検討
- Author(s)
  東正新、渡辺守、他
- Organizer
  第３９回日本肝臓学会東部会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590959
[Presentation] 細胞障害性HCV-JFH1subcloneの単離と機能解析
- Author(s)
  三島果子、坂本直哉、筬島裕子、中川美奈、藤田めぐみ、櫻井幸、須田剛生、唐鎌優子、山本満千、渡辺貴子、植山真由美、船岡祐介、幾世橋佳、新田沙由梨、北詰晶子、井津井康浩、柿沼晴、陳正新、脇田隆字、渡辺守
- Organizer
  京都(ポスター)
- Data Source
  KAKENHI-PROJECT-21590832
[Presentation] Matrix Metalloproteinase-14 controls differentiation of fetal hepatic stem/progenitor cells.
- Author(s)
  Otani S, Kakinuma S, Kamiya A, Goto F, Kaneko S, Azuma S, Asahina Y, Watanabe M.
- Organizer
  Japan Digesive Disease Week 2014
- Place of Presentation
  ポートピアホテル（神戸）
- Year and Date
  2014-10-23 – 2014-10-26
- Data Source
  KAKENHI-PROJECT-24590959
[Presentation] Matrix Metalloproteinase-14 による肝幹/前駆細胞分化の調節
- Author(s)
  大谷賢志、柿沼　晴、後藤文男、紙谷聡英、新田沙由梨、東　正新、中川美奈、朝比奈靖浩、坂本直哉、中内啓光、渡辺　守
- Organizer
  第５０回日本肝臓学会総会
- Place of Presentation
  ホテルニューオータニ（東京）
- Year and Date
  2014-05-29 – 2014-05-30
- Data Source
  KAKENHI-PROJECT-24590959
[Presentation] Wnt5a-CaMK2経路によるマウス肝幹/前駆細胞の胆管形成の調節
- Author(s)
  幾世橋佳、柿沼晴、東正新、渡辺守、他
- Organizer
  第48回日本肝臓学会総会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-24590959

1. WATANABE Mamoru (10175127)

# of Collaborated Projects: 11 results

# of Collaborated Products: 141 results
2. SAKAMOTO Naoya (10334418)

# of Collaborated Projects: 9 results

# of Collaborated Products: 114 results
3. KAKINUMA Sei (30372444)

# of Collaborated Projects: 9 results

# of Collaborated Products: 93 results
4. ASAHINA Yasuhiro (00422692)

# of Collaborated Projects: 5 results

# of Collaborated Products: 70 results
5. TASAKA Megumi (50510369)

# of Collaborated Projects: 3 results

# of Collaborated Products: 24 results
6. NAKAGAWA Mina (30401342)

# of Collaborated Projects: 3 results

# of Collaborated Products: 36 results
7. ITSUI Yasuhiro (20401341)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
8. OSAJIMA Yuko (40451934)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
9. OOOKA Shinya (90361691)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. SUZUKI Shinji (10456212)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 岡本隆一 (50451935)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 新田沙由梨

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
13. 田中真二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 米山光俊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 紙谷聡英

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

AZUMA SEISHIN 東 正新

AZUMA Seishin 東 正新

陳正新

陳 正新

東 正新(陳正新) アヅマ セイシン

CHEN Cheng-Hsin 陳 正新

CHEN Cheng-hsin 陳 正新

Research Projects

Research Products

Co-Researchers

肝星細胞におけるTNFシグナルを基軸とした肝線維化分子機構の解明Principal Investigator

Principal Investigator

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Review Section

Research Institution

Analysis of cell-to-cell interaction between hepatic progenitor cells and hepatic mesenchymal cells and a search of target molecules for a therapy of liver fibrosisPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

Research on molecular mechanisms underlying terminal differentiation of hepatic stem/progenitor cells via non-canonical Wnt signaling pathwaysPrincipal Investigator

Principal Investigator

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Study on establishment of experimental animal model for chimeric liver with hepatitis C virus infection using induced hepatocyte-like cellsPrincipal Investigator

Principal Investigator

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High-throughput screening of virus-and host-targeted suppressors of HCV infection

Principal Investigator

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FRET/ BRET analysis of interaction between HCV protein and interferon signaling

Principal Investigator

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Development of plaque assay to isolate cytopathic HCV clones

Principal Investigator

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Analysis on molecular mechanisms of liver reconstitution by transplanted hepatic cellsPrincipal Investigator

Principal Investigator

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Search for new classes of HCV therapeutics by large scale screening of antiviral compounds and host cellular factors

Principal Investigator

Project Period (FY)

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Research on transplantation of hepatic stem cells and development of experimental mouse models for hepatitis C virusPrincipal Investigator

Principal Investigator

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Research Institution

Study on hepatic differentiation of mesenchymal stem cells derived from human umbilical cord blood, and cell therapy for liver disease by use of mesenchymal stem cells.Principal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

[Journal Article] Time course alterations of virus sequences and immunoglobulin titers in a chronic hepatitis E patient2020

Author(s)

Journal Title

DOI

AZUMA SEISHIN 東正新

AZUMA Seishin 東正新

陳正新

東正新(陳正新) アヅマセイシン

CHEN Cheng-Hsin 陳正新

CHEN Cheng-hsin 陳正新