Naganuma Makoto 長沼誠

… Alternative Names

NAGANUMA Makoto 長沼誠

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Researcher Number	00265810
Other IDs
Affiliation (Current)	2023: 関西医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2020 – 2022: 関西医科大学, 医学部, 教授 2020: 慶應義塾大学, 医学部(信濃町), 客員教授 2018 – 2019: 慶應義塾大学, 医学部(信濃町), 准教授 2017: 慶應義塾大学, 医学部, 准教授 2017: 慶應義塾大学, 医学部, 講師 … More 2016: 慶應義塾大学, 医学部(信濃町), 講師 2015: 慶應義塾大学, 医学部, 講師 2012: 東京医科歯科大学, 医学部, 非常勤講師 2010 – 2011: 東京医科歯科大学, 大学院・医歯学総合研究科, 寄附講座教員 2000 – 2001: 慶應義塾大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Gastroenterology / Gastroenterology / Basic Section 53010:Gastroenterology-related Except Principal Investigator Gastroenterology / Medium-sized Section 53:Organ-based internal medicine and related fields / Basic Section 58010:Medical management and medical sociology-related
Keywords	Principal Investigator 炎症性腸疾患 / 潰瘍性大腸炎 / 腸内細菌叢 / TPMT遺伝子多型 / 免疫抑制剤 / 炎症性発癌 / 新規治療法 / 粘膜免疫 / MLCK / 炎症性腸管 … More / IL-7 / IL-7レセプター / 腸管免疫 / ジフテリア毒素 / トランスジェニックマウス / ノックアウトマウス / interleukin-7 / interleukin-7 receptor / mucosal immunology / knock-out mice / T lymphocytes / inflammatory bowel disease / diphteria toxin / AhR リガンド / 生薬青黛 / 大腸癌 / 青黛 / Aryl Hydrocarbon受容体 / 疾患活動性 / カルプロテクチン / 難治性 / 5-ASA製剤不耐 / 活性化血小板 / バイオマーカー … More Except Principal Investigator 腸内細菌 / 炎症性腸疾患 / 潰瘍性大腸炎 / 原発性硬化性胆管炎 / 腸管外合併症 / Th17細胞 / 下部消化管学 / 下部消化管 / 免疫学 / 青黛 / インジゴ類 / 潰瘍性大腸炎（UC） / AhRコンディショナルノックアウトマウス / 腸内細菌叢 / 腸管微小循環 / メタゲノム解析 / アルコール性肝障害 / アルコール使用障害 / e-Health / スマートフォンアプリ / 医療言語処理 Less

活性化血小板をターゲットとした炎症性腸疾患バイオマーカー同定と新規治療法の開発Principal Investigator
- Principal Investigator
  
  長沼誠
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kansai Medical University
禁酒継続に向け医療者ー患者双方向を支援するデジタルヘルス環境の構築
- Principal Investigator
  
  山敷宣代
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 58010:Medical management and medical sociology-related
- Research Institution
  Kansai Medical University
Analysis of intestinal and oral bacterial flora in patients with ulcerative colitis aimed for optimization of treatmentPrincipal Investigator
- Principal Investigator
  
  NAGANUMA Makoto
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kansai Medical University
  Keio University
The elucidation of the World of AhR in the intestinal environment ,followed by the diverse clinical applications.
- Principal Investigator
  
  KANAI Takanori
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Keio University
Investigation of the mechanisms for inhibitory effects on colonic inflammation and cancer of indigo naturalis including indole compoundsPrincipal Investigator
- Principal Investigator
  
  Naganuma Makoto
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University
To identify the mechanism of inflammatory bowel disease by using human microbe mono-associated mouse
- Principal Investigator
  
  KANAI TAKANORI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University
Identification of the inflammatory signaling in intestinal epithelial cells involvedPrincipal Investigator
- Principal Investigator
  
  NAGANUMA Makoto
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
遺伝子多型性の解析に基づいた炎症性腸疾患に対する新しい免疫抑制剤投与法の開発Principal Investigator
- Principal Investigator
  
  長沼誠
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University
New therapy targeting IL-7 receptor positive lymphocytes for chronic intestinal inflammationPrincipal Investigator
- Principal Investigator
  
  NAGANUMA Makoto
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University

All 2022 2021 2020 2019 2018 2017 2016 2015 2013 2012 2011 2010 Other

All Journal Article Presentation Book

[Book] Japanese Journal of Clinical Immunology2012
- Author(s)
  長沼誠、渡辺　守、他
- Publisher
  日本臨床免疫学会
- Data Source
  KAKENHI-PROJECT-22590696
[Book] Intestine2012
- Author(s)
  長沼誠、渡辺　守
- Total Pages
  6
- Publisher
  日本メディカルセンター
- Data Source
  KAKENHI-PROJECT-22590696
[Book] Medical Practice2012
- Author(s)
  長沼誠、渡辺　守
- Total Pages
  5
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-22590696
[Book] 免疫調節薬(炎症性腸疾患)2010
- Author(s)
  長沼越
- Total Pages
  3
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-22590696
[Book] 日本消化器病学会雑誌(クローン病小腸病変の診断と治療)1072010
- Author(s)
  長沼越, 玄世鋒, 渡辺守
- Publisher
  日本消化器病学会雑誌
- Data Source
  KAKENHI-PROJECT-22590696
[Book] 胃と腸(Crohn病小腸病変に対する治療効果免疫調節薬の粘膜治癒効果)452010
- Author(s)
  長沼越, 今枝博之, 緒方晴彦, 岩男泰, 日比紀文, 渡辺守
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-22590696
[Book] 治療学(クローン病に対する抗TNFa抗体療法)442010
- Author(s)
  長沼越
- Total Pages
  6
- Publisher
  ライフサイエンス出版
- Data Source
  KAKENHI-PROJECT-22590696
[Book] 消化器内科(小腸炎症性腸疾患診断におけるカプセル内視鏡とバルーン内視鏡の有用性)502010
- Author(s)
  長沼越, 渡辺守
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-22590696
[Book] .臨床消化器内科(タクロリムス(プログラフ))252010
- Author(s)
  長沼越, 長堀正和, 渡辺守
- Publisher
  日本メディカルセンタ
- Data Source
  KAKENHI-PROJECT-22590696
[Journal Article] A review on the current status and definitions of activity indices in inflammatory bowel disease: how to use indices for precise evaluation2022
- Author(s)
  Kishi M, Hirai F, Takatsu N, Hisabe T, Takada Y, Beppu T, Takeuchi K, Naganuma M, Ohtsuka K, Watanabe K, Matsumoto T, Esaki M, Koganei K, Sugita A, Hata K, Futami K, Ajioka Y, Tanabe H, Iwashita A, Shimizu H, Arai K, Suzuki Y, Hisamatsu T.
- Journal Title
  
  J Gastroenterol.
  
  Volume: 4 Pages: 246-266
- DOI
  10.1007/s00535-022-01862-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08381
[Journal Article] Potential benefits of immunomodulator use with vedolizumab for maintenance of remission in ulcerative colitis2022
- Author(s)
  Naganuma Makoto, Watanabe Kenji, Motoya Satoshi, Ogata Haruhiko, Matsui Toshiyuki, Suzuki Yasuo, ursos Lyann, Sakamoto Shigeru, Shikamura Mitsuhiro, Hori Tetsuharu, Frenandez Jovelle, Watanabe Mamoru, Hibi Toshifumi, Kanai Takanori
- Journal Title
  
  Journal of Gastroenterology and Hepatology
  
  Volume: 1 Pages: 81-88
- DOI
  10.1111/jgh.15667
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08381, KAKENHI-PROJECT-21H02905
[Journal Article] Prospective feasibility study of indigo naturalis ointment for chemotherapy-induced oral mucositis2022
- Author(s)
  Hirata K, Yamada Y, Hamamoto Y, Tsunoda K, Muramatsu H, Horie S, Sukawa Y, Naganuma M, Nakagawa T, Kanai T
- Journal Title
  
  BMJ Support Palliat Care .
  
  Volume: Oct 14
- DOI
  10.1136/bmjspcare-2021-003199
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08381
[Journal Article] Significance of endoscopic deep small bowel evaluation using balloon-assisted enteroscopy for Crohn's disease in clinical remission.2021
- Author(s)
  Takabayashi Kaoru、Hosoe Naoki、Kato Motohiko、Hayashi Yukie、Nanki Kosaku、Fukuhara Kayoko、Mikami Yohei、Mizuno Shinta、Sujino Tomohisa、Mutaguchi Makoto、Naganuma Makoto、Yahagi Naohisa、Ogata Haruhiko、Kanai Takanori
- Journal Title
  
  J Gastroenterol
  
  Volume: 56 Pages: 25-33
- DOI
  10.1007/s00535-020-01737-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H05082, KAKENHI-PROJECT-20H03665, KAKENHI-PROJECT-19K22624, KAKENHI-PROJECT-18KK0246
[Journal Article] Characteristics of the Mucosal Surface on Scanning Electron Microscopy in Patients with Remitting Ulcerative Colitis.2021
- Author(s)
  Nomura E, Sujino T, Hosoe N, Yoshimatsu Y, Tanemoto S, Takabayashi K, Mutaguchi M, Shimoda M, Naganuma M, Ogata H, Kanai T.
- Journal Title
  
  Dig Dis Sci
  
  Volume: - Pages: 1-10
- DOI
  10.1007/s10620-020-06609-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08402, KAKENHI-PROJECT-19K16592, KAKENHI-PROJECT-17H05082, KAKENHI-PROJECT-19K22624, KAKENHI-PROJECT-18KK0246, KAKENHI-PROJECT-20H03665
[Journal Article] Phase 1 study on the safety and efficacy of E6011, antifractalkine antibody, in patients with Crohn's disease.2021
- Author(s)
  Matsuoka K., Naganuma M., Hibi T., Tsubouchi H., Oketani K., Katsurabara T., Hojo S., Takenaka O., Kawano T., Imai T., Kanai T.
- Journal Title
  
  J Gastroenterol Hepatol
  
  Volume: -
- DOI
  10.1111/jgh.15463
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18KK0246
[Journal Article] 炎症性腸疾患に対する生物学的製剤・JAK阻害剤―IBD診療ガイドライン2020を読み解く―2021
- Author(s)
  長沼誠, 深田憲将, 福井寿朗
- Journal Title
  
  日本消化器病学会雑誌
  
  Volume: 8 Pages: 618-627
- NAID
  130008064498
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08381
[Journal Article] Pulmonary Arterial Hypertension Caused by AhR Signal Activation Protecting against Colitis2021
- Author(s)
  Hiraide T., Teratani T., Uemura S., Yoshimatsu Y., Naganuma M., Shinya Y., Momoi M., Kobayashi E., Hakamata Y., Fukuda K., Kanai T., Kataoka M.
- Journal Title
  
  American Journal of Respiratory Critical Care Medicine
  
  Volume: 203 Pages: 385-388
- DOI
  10.1164/rccm.202009-3385le
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18KK0246, KAKENHI-PROJECT-18K08154
[Journal Article] 5-Aminosalicylic acid intolerance is associated with a risk of adverse clinical outcomes and dysbiosis in patients with ulcerative colitis.2020
- Author(s)
  Mizuno S, Naganuma M, Kanai T et al.
- Journal Title
  
  Intestinal Research
  
  Volume: 18 Pages: 69-78
- DOI
  10.5217/ir.2019.00084
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08381
[Journal Article] Solving the questions regarding 5-aminosalitylate formulation in the treatment of ulcerative colitis2020
- Author(s)
  Naganuma M
- Journal Title
  
  J Gastroenterol
  
  Volume: 55 Pages: 1013-1022
- DOI
  10.1007/s00535-020-01713-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08381
[Journal Article] Mucosal concentrations of N‐acetyl‐5‐aminosalicylic acid related to endoscopic activity in ulcerative colitis patients with mesalamine2020
- Author(s)
  Fukuda T, Naganuma M, Takabayashi K, Hagihara Y, Tanemoto S, Nomura E, Yoshimatsu Y, Sugimoto S, Nanki K, Mizuno S, Mikami Y, Fukuhara K, Sujino T, Mutaguchi M, Inoue N, Ogata H, Iwao Y, Abe T, Kanai T.
- Journal Title
  
  J Gastroenterol Hepatol
  
  Volume: 35 Pages: 1878-1885
- DOI
  10.1111/jgh.15059
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08381, KAKENHI-PROJECT-17H05082, KAKENHI-PROJECT-20H03665, KAKENHI-PROJECT-20H03746, KAKENHI-PROJECT-18KK0246
[Journal Article] Indigo naturalis is effective even in treatment-refractory patients with ulcerative colitis: a post hoc analysis from the INDIGO study2020
- Author(s)
  Naganuma M, Sugimoto S, Fukuda T, Mitsuyama K, Kobayashi T, Yoshimura N, Ohi H, Tanaka S, Andoh A, Ohmiya N, Saigusa K, Yamamoto T, Morohoshi Y, Ichikawa H, Matsuoka K, Hisamatsu T, Watanabe K, Mizuno S, Abe T, Suzuki Y, Kanai T; INDIGO Study Group.
- Journal Title
  
  J Gastroenterol
  
  Volume: 55 Pages: 169-180
- DOI
  10.1007/s00535-019-01625-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08014, KAKENHI-PROJECT-18KK0246, KAKENHI-PROJECT-18H03172
[Journal Article] Efficacy of apheresis as maintenance therapy for patients with ulcerative colitis in an open-label prospective multicenter randomised controlled trial.2020
- Author(s)
  Naganuma M, Yokoyama Y, Motoya S, Watanabe K, Sawada K, Hirai F, Yamamoto T, Hanai H, Omori T, Kanai T, Hibi T
- Journal Title
  
  J Gastroenterol
  
  Volume: 4 Pages: 390-400
- DOI
  10.1007/s00535-019-01651-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18KK0246
[Journal Article] Significance of conducting 2 types of fecal tests in patients with ulcerative colitis2020
- Author(s)
  Naganuma M, Kobayashi T, Nasuno M, Motoya S, Kato S, Matsuoka K, Hokari R, Watanabe C, Sakamoto H, Yamamoto H, Sasaki M, Watanabe K, Iijima H, Endo Y, Ichikawa H, Ozeki K, Tanida S, Ueno N, Fujiya M, Sako M, Takeuchi K, Sugimoto S, Abe T, Hibi T, Suzuki Y, Kanai T.
- Journal Title
  
  Clin Gastroenterol Hepatol
  
  Volume: 19 Pages: 1102-1110
- DOI
  10.1016/j.cgh.2019.07.054
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18KK0246, KAKENHI-PROJECT-19K08381
[Journal Article] Efficacy of Novel Ultrathin Single-Balloon Enteroscopy for Crohn’s Disease: A Propensity Score-Matched Study2020
- Author(s)
  Takabayashi Kaoru、Hosoe Naoki、Kato Motohiko、Hayashi Yukie、Miyanaga Ryoichi、Nanki Kosaku、Fukuhara Kayoko、Mikami Yohei、Mizuno Shinta、Sujino Tomohisa、Mutaguchi Makoto、Naganuma Makoto、Yahagi Naohisa、Ogata Haruhiko、Kanai Takanori
- Journal Title
  
  Gut Liver
  
  Volume: - Pages: 1-6
- DOI
  10.5009/gnl19228
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08402, KAKENHI-PROJECT-19K22624, KAKENHI-PROJECT-17H05082, KAKENHI-PROJECT-20H03665, KAKENHI-PROJECT-18KK0246
[Journal Article] Development of an Indigo Naturalis Suppository for Topical Induction Therapy in Patients with Ulcerative Colitis.2019
- Author(s)
  Yoshimatsu Yusuke、Naganuma Makoto、Sugimoto Shinya、Tanemoto Shun、Umeda Satoko、Fukuda Tomohiro、Nomura Ena、Yoshida Kosuke、Ono Keiko、Mutaguchi Makoto、Nanki Kosaku、Mizuno Shinta、Mikami Yohei、Fukuhara Kayoko、Sujino Tomohisa、Takabayashi Kaoru、Ogata Haruhiko、Iwao Yasushi、Kanai Takanori
- Journal Title
  
  Digestion
  
  Volume: 1 Pages: 492-498
- DOI
  10.1159/000501152
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22624, KAKENHI-PROJECT-18KK0246, KAKENHI-PROJECT-17H05082
[Journal Article] Long‐term effect of NUDT15 R139C on hematologic indices in inflammatory bowel disease patients treated with thiopurine2019
- Author(s)
  Akiyama Shintaro、Takenaka Kento、et al
- Journal Title
  
  J Gastroenterol Hepatol
  
  Volume: 34 Pages: 1751-1757
- DOI
  10.1111/jgh.14693
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07902, KAKENHI-PROJECT-19K05914, KAKENHI-PROJECT-18KK0246, KAKENHI-PROJECT-15K08045, KAKENHI-PROJECT-17K09370
[Journal Article] Middle-term prognosis in patients with ulcerative colitis who achieved clinical and endoscopic remission by budesonide rectal foam.2019
- Author(s)
  Naganuma M, Hirai F, Kobayashi K, Watanabe K, Takeuchi K, Aoyama N, Nozawa H, Motoya S, Ohmori T, Harada A, Nagai Y, Abe T, Yamada Y, Inagaki K, Shimizu N, Kanai T, Watanabe M.
- Journal Title
  
  PLoS One
  
  Volume: 14
- DOI
  10.1371/journal.pone.0220413
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18KK0246
[Journal Article] Toll-Like Receptor 7 Agonist?Induced Dermatitis Causes Severe Dextran Sulfate Sodium Colitis by Altering the Gut Microbiome and Immune Cells2019
- Author(s)
  Kiyohara H, Sujino T, Teratani T, Miyamoto K, Arai MM, Nomura E, Harada Y, Aoki R, Koda Y, Mikami Y, Mizuno S, Naganuma M, Hisamatsu T, Kanai T.
- Journal Title
  
  Cell Mol Gastroenterol Hepatol
  
  Volume: 7 Pages: 135-156
- DOI
  10.1016/j.jcmgh.2018.09.010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08014, KAKENHI-PROJECT-17H05082, KAKENHI-PROJECT-17K19668, KAKENHI-PROJECT-17K15966, KAKENHI-PROJECT-18KK0246
[Journal Article] How Can We Assess "Complete Healing" Beyond Endoscopic Remission?2019
- Author(s)
  Fukuda T, Naganuma M, Kanai T.
- Journal Title
  
  Inflamm Bowel Dis
  
  Volume: 25
- DOI
  10.1093/ibd/izy356
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18KK0246
[Journal Article] Adverse events in patients with ulcerative colitis treated with indigo naturalis: a Japanese nationwide survey.2019
- Author(s)
  Naganuma M, Sugioto S, Suzuki H, Matsuno Y, Araki T, Shimizu H, Hayashi R, Fukuda T, Nakamoto N, Iijima H, Nakamura S, Kataoka M, Tamura Y, Tatsumi K, Hibi T, Suzuki Y, Kani T, INDIGO survey Group
- Journal Title
  
  J Gastroenterol
  
  Volume: 54(10) Pages: 891-896
- DOI
  10.1007/s00535-019-01591-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08183, KAKENHI-PROJECT-18KK0246
[Journal Article] Idiopathic Thrombocytopenic Purpura Responsive to Surgery for Crohn's Disease2019
- Author(s)
  Mizuno S, Naganuma M, Kanai T
- Journal Title
  
  Inflamm Bowel Dis
  
  Volume: 25
- DOI
  10.1093/ibd/izy233
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18KK0246
[Journal Article] Efficacy of Therapeutic Intervention for Patients With an Ulcerati Colitis Mayo Endoscopic Score of 12019
- Author(s)
  Fukuda T, Naganuma M, Sugimoto S, Ono K, Nanki K, Mizuno S, Kimura K, Mutaguchi M, Nakazato Y, Takabayashi K, Inoue N, Ogata H, Iwao Y, Kanai T.
- Journal Title
  
  Inflamm Bowel Dis
  
  Volume: 25 Pages: 782-788
- DOI
  10.1093/ibd/izy300
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18KK0246
[Journal Article] Difference in the clinical characteristic and prognosis of colitis-associated cancer and sporadic neoplasia in ulcerative colitis patients2019
- Author(s)
  Mutaguchi Makoto、Naganuma Makoto、Sugimoto Shinya、Fukuda Tomohiro、Nanki Kosaku、Mizuno Shinta、Hosoe Naoki、Shimoda Masayuki、Ogata Haruhiko、Iwao Yasushi、Kanai Takanori
- Journal Title
  
  Dig Liver Dis
  
  Volume: 51 Pages: 1257-1264
- DOI
  10.1016/j.dld.2019.05.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08402, KAKENHI-PROJECT-18KK0246
[Journal Article] Withdrawal of thiopurines in Crohn's disease treated with scheduled adalimumab maintenance: a prospective randomised clinical trial (DIAMOND2).2019
- Author(s)
  Hisamatsu Tadakazu、DIAMOND2 Study Group、Kato Shingo、Kunisaki Reiko、Matsuura Minoru、Nagahori Masakazu、Motoya Satoshi、Esaki Motohiro、Fukata Norimasa、Inoue Satoko、Sugaya Takeshi、Sakuraba Hirotake、Hirai Fumihito、Watanabe Kenji、Kanai Takanori、Naganuma Makoto、Nakase Hiroshi、et al.
- Journal Title
  
  J Gastroenterol
  
  Volume: 54 Pages: 860-870
- DOI
  10.1007/s00535-019-01582-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07947, KAKENHI-PROJECT-18KK0246
[Journal Article] Current new challenges in the management of ulcerative colitis.2019
- Author(s)
  Fukuda T, Naganuma M, Kanai T.
- Journal Title
  
  Intest Res
  
  Volume: 17 Pages: 36-44
- DOI
  10.5217/ir.2018.00126
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18KK0246
[Journal Article] Intramucosal poorly differentiated and signet-ring cell components in patients with ulcerative colitis-associated high-grade dysplasia.2019
- Author(s)
  Sugimoto S, Shimoda M, Iwao Y, Mutaguchi M, Nanki K, Mizuno S, Kameyama K, Ogata H, Naganuma M, Kanai T.
- Journal Title
  
  Dig Endosc
  
  Volume: 6 Pages: 706-711
- DOI
  10.1111/den.13482
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18KK0246
[Journal Article] Efficacy of Indigo Naturalis in a Multicenter Randomized Controlled Trial of Patients with Ulcerative Colitis2018
- Author(s)
  .Naganuma M, Sugimoto S, Mitsuyama K, Kobayashi T, Yoshimura N, Ohi H, Tanaka S, Andoh A, Ohmiya N, Saigusa K, Yamamoto T, Morohoshi Y, Ichikawa H, Matsuoka K, Hisamatsu T, Watanabe K, Mizuno S, Suda W, Hattori M, Fukuda S, Hirayama A, Abe T, Watanabe M, Hibi T, Suzuki Y, Kanai T
- Journal Title
  
  Gastroenterology.
  
  Volume: 4 Pages: 935-947
- DOI
  10.1053/j.gastro.2017.11.024
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H02534, KAKENHI-PROJECT-15J00981, KAKENHI-PROJECT-15K08564, KAKENHI-PROJECT-15K21364, KAKENHI-PROJECT-18K07947, KAKENHI-PROJECT-16K09326
[Journal Article] Intestinal Dysbiosis and Biotin Deprivation Induce Alopecia through Overgrowth of Lactobacillus murinus in Mice2017
- Author(s)
  Hayashi Atsushi、Mikami Yohei、Miyamoto Kentaro、Kamada Nobuhiko、Sato Toshiro、Mizuno Shinta、Naganuma Makoto、Teratani Toshiaki、Aoki Ryo、Fukuda Shinji、Suda Wataru、Hattori Masahira、Amagai Masayuki、Ohyama Manabu、Kanai Takanori
- Journal Title
  
  Cell Rep
  
  Volume: 20 Pages: 1513-1524
- DOI
  10.1016/j.celrep.2017.07.057
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26115007, KAKENHI-PROJECT-17H06176, KAKENHI-PROJECT-15H02534, KAKENHI-PROJECT-15K19348
[Journal Article] Single fecal microbiota transplantation failed to change intestinal microbiota and had limited effectiveness against ulcerative colitis in Japanese patients.2017
- Author(s)
  Mizuno S, Nanki K, Matsuoka K, Saigusa K, Ono K, Arai M, Sugimoto S, Kiyohara H, Nakashima M, Takeshita K, Naganuma M, Suda W, Hattori M, Kanai T.
- Journal Title
  
  Intestinal Research
  
  Volume: 15(1) Pages: 68-74
- DOI
  10.5217/ir.2017.15.1.68
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H02534, KAKENHI-PROJECT-15J00981, KAKENHI-PROJECT-15K15298
[Journal Article] Endoscopic morphologic features of ulcerative colitis-associated dysplasia classified according to the SCENIC consensus statement.2017
- Author(s)
  Sugimoto S, Naganuma M, Iwao Y, Matsuoka K, Shimoda M, Mikami S, Mizuno S, Nakazato Y, Nanki K, Inoue N, Ogata H, Kanai T.
- Journal Title
  
  Gastrointest Endosc
  
  Volume: 85(3) Pages: 639-46
- DOI
  10.1016/j.gie.2016.11.013
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H02534, KAKENHI-PROJECT-15J00981, KAKENHI-PROJECT-15K15298, KAKENHI-PROJECT-15K08974, KAKENHI-PROJECT-16K08657
[Journal Article] Endoscopic Severity Predicts Long-Term Prognosis in Crohn's Disease Patients with Clinical Remission2016
- Author(s)
  Naganuma M, Okuda S, Hisamatsu T, Matsuoka K, Mori K, Hosoe N, Nakazato Y, Ogata H, Kanai T.
- Journal Title
  
  Digestion
  
  Volume: 42(1) Pages: 141-151
- DOI
  10.1007/s00261-016-0878-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02534, KAKENHI-PROJECT-15K15298
[Journal Article] Indole compounds may be promising medicines for ulcerative colitis.2016
- Author(s)
  Sugimoto S, Naganuma M, Kanai T.
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: 51(9) Pages: 853-61
- DOI
  10.1007/s00535-016-1220-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02534, KAKENHI-PROJECT-15J00981, KAKENHI-PROJECT-15K15298, KAKENHI-PROJECT-16K09326
[Journal Article] Ulcerative Colitis Endoscopic Index of Severity is Useful to Predict Medium- to Long-Term Prognosis in Ulcerative Colitis Patients with Clinical Remission.2016
- Author(s)
  Arai M, Naganuma M, Sugimoto S, Kiyohara H, Ono K, Mori K, Saigusa K, Nanki K, Mutaguchi M, Mizuno S, Bessho R, Nakazato Y, Hosoe N, Matsuoka K, Inoue N, Ogata H, Iwao Y, Kanai T.
- Journal Title
  
  Journal of Crohn's and Colitis
  
  Volume: 10(11) Pages: 1303-1309
- DOI
  10.1093/ecco-jcc/jjw104
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H02534, KAKENHI-PROJECT-15J00981, KAKENHI-PROJECT-15K15298, KAKENHI-PROJECT-15K08974
[Journal Article] Up-to-date medical treatment for ulcerative colitis2016
- Author(s)
  Kiyohara H, Mizuno S, Naganuma M, Kanai T
- Journal Title
  
  Nippon Shokakibyo Gakkai Zasshi
  
  Volume: 113(3) Issue: 3 Pages: 413-23
- DOI
  10.11405/nisshoshi.113.413
- NAID
  130005131305
- ISSN
  0446-6586, 1349-7693
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K15298, KAKENHI-PROJECT-15H02534
[Journal Article] Clinical Efficacy and Safety of Oral Qing-Dai in Patients with Ulcerative Colitis: A Single-Center Open-Label Prospective Study.2016
- Author(s)
  Sugimoto S, Naganuma M, Kiyohara H, Arai M, Ono K, Mori K, Saigusa K, Nanki K, Takeshita K, Takeshita T, Mutaguchi M, Mizuno S, Ogata H, Iwao Y, Kanai T
- Journal Title
  
  Digestion
  
  Volume: 93 Pages: 193-201
- DOI
  10.1159/000444217
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08974, KAKENHI-PROJECT-15H02534, KAKENHI-PROJECT-15K15298
[Journal Article] Computer-Aided Prediction of Long-Term Prognosis of Patients with Ulcerative Colitis after Cytoapheresis Therapy2015
- Author(s)
  7.Takayama T, Okamoto S, Hisamatsu T, Naganuma M, Matsuoka K, Mizuno S, Bessho R, Hibi T, Kanai T
- Journal Title
  
  PLoS One
  
  Volume: 10(6)
- DOI
  10.1371/journal.pone.0131197
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K15298, KAKENHI-PROJECT-15H02534
[Journal Article] Crohn's Disease in which the Patient Developed Aortitis during Treatment with Adalimumab2015
- Author(s)
  6.Kiyohara H, Hisamatsu T, Matsuoka K, Naganuma M, Kameda H, Seta N, Takeuchi T, Kanai T
- Journal Title
  
  Internal Medicine
  
  Volume: 54(14) Issue: 14 Pages: 1725-1732
- DOI
  10.2169/internalmedicine.54.3853
- NAID
  130005088259
- ISSN
  0918-2918, 1349-7235
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K15298, KAKENHI-PROJECT-15H02534
[Journal Article] Decreased Plasma Histidine Level Predicts Risk of Relapse in Patients with Ulcerative Colitis in Remission2015
- Author(s)
  Hisamatsu T, Ono N, Imaizumi A, Mori M, Suzuki H, Uo M, Hashimoto M, Naganuma M, Matsuoka K, Mizuno S, Kitazume MT, Yajima T, Ogata H, Iwao Y, Hibi T, Kanai T
- Journal Title
  
  PLoS One
  
  Volume: 10 Pages: 1-10
- DOI
  10.1371/journal.pone.0140716
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08974, KAKENHI-PROJECT-15K15298, KAKENHI-PROJECT-15H02534
[Journal Article] Recent trends in diagnostic techniques for inflammatory bowel disease2015
- Author(s)
  Naganuma M, Hosoe N, Kanai T, Ogata H
- Journal Title
  
  Korean J Intern Med
  
  Volume: 30(3) Pages: 271-8
- DOI
  10.3904/kjim.2015.30.3.271
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K15298, KAKENHI-PROJECT-15H02534
[Journal Article] Inflammatory bowel disease and the intestinal microbiota2015
- Author(s)
  3.Nanki K, Mizuno S, Naganuma M, Kanai T
- Journal Title
  
  Nippon Shokakibyo Gakkai Zasshi
  
  Volume: 112(11) Issue: 11 Pages: 1947-1955
- DOI
  10.11405/nisshoshi.112.1947
- NAID
  130005107575
- ISSN
  0446-6586, 1349-7693
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K15298, KAKENHI-PROJECT-15H02534
[Journal Article] Poor recall of prior exposure to varicella zoster, rubella, measles, or mumps in patients with IBD.2013
- Author(s)
  Naganuma M, Nagahori M, Fujii T, Morio J, Saito E, Watanabe M
- Journal Title
  
  Inflamm Bowel Dis.
  
  Volume: 19 Pages: 418-22
- DOI
  10.1002/ibd.23027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590696, KAKENHI-PROJECT-23590934, KAKENHI-PROJECT-24590937
[Journal Article] Incidence and characteristics of the 2009 influenza (H1N1) infections in inflammatory bowel disease patients2013
- Author(s)
  Naganuma M, Fujii T, Kunisaki R, Yoshimura N, Takazoe M, Takeuchi Y, Saito E, Nagahori M, Asakura K, Takebayashi T, Watanabe M
- Journal Title
  
  J Crohns Colitis
  
  Volume: 7 Pages: 308-313
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590696
[Journal Article] Incidence and characteristics of the 2009 influenza (H1N1) infections in inflammatory bowel disease patients.2013
- Author(s)
  Naganuma M, Nagahori M, Watanabe M et al.
- Journal Title
  
  J Crohns Colitis
  
  Volume: 7(4) Pages: 308-313
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590696
[Journal Article] Magnetic resonance enterocolonography is useful for simultaneous evaluation of small and lage intestinal lesions in Crohn's disease2011
- Author(s)
  Hyun SB, Kitazume Y, Suzuki S, Watanabe M, et al
- Journal Title
  
  Inflamm Bowel Dis.
  
  Volume: 17 Pages: 1063-1072
- DOI
  10.1002/ibd.21510
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590805, KAKENHI-PROJECT-21590806, KAKENHI-PROJECT-22590694, KAKENHI-PROJECT-22590695, KAKENHI-PROJECT-22590696, KAKENHI-PUBLICLY-23130506, KAKENHI-PROJECT-23590934
[Journal Article] Conception and pregnancy outcome in women with inflammatory bowel disease: A multicentre study from Japan2011
- Author(s)
  Naganuma M, Nagahori M, Watanabe M, et al
- Journal Title
  
  J Crohns Colitis
  
  Volume: 5 Pages: 317-323
- DOI
  10.1016/j.crohns.2011.02.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590806, KAKENHI-PROJECT-22590696
[Journal Article] The use of traditional and newer calcineurin inhibitors in inflammatory bowel disease2011
- Author(s)
  Naganuma M, Watanabe M, Hibi T
- Journal Title
  
  J Gastroenterol.
  
  Volume: 46 Pages: 129-137
- DOI
  10.1007/s00535-010-0352-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590806, KAKENHI-PROJECT-22590696, KAKENHI-PROJECT-23590934
[Journal Article] Safety and usefulness of balloon endoscopy in Crohn's disease patients with postoperative ileal lesions2011
- Author(s)
  Naganuma M, Watanabe M, Hibi T
- Journal Title
  
  J Crohns Colitis
  
  Volume: 5 Pages: 73-74
- DOI
  10.1016/j.crohns.2010.10.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590806, KAKENHI-PROJECT-22590696
[Journal Article] Novel endoscopic activity index is useful for choosing treatment in severe active ulcerative colitis patients.2010
- Author(s)
  Naganuma M, et al.
- Journal Title
  
  J Gastroenterol
  
  Volume: 45 Pages: 936-943
- NAID
  10027698991
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590696
[Journal Article] Prevalence of metabolic syndrome is comparable between inflammatory bowel disease patients and the general population.2010
- Author(s)
  Nagahori M, Naganuma M, Watanabe M, et al.
- Journal Title
  
  J Gastroenterol
  
  Volume: 45 Pages: 1008-1013
- NAID
  10027699223
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590696
[Journal Article] Prevalence of metabolic syndrome is comparable between inflammatory bowel disease patients and the general population2010
- Author(s)
  Nagahori M, Hyun SB, Totsuka T, Okamoto R, Kuwahara E, Takebayashi T, Naganuma M, Watanabe M
- Journal Title
  
  J Gastroenterol
  
  Volume: 45 Pages: 1008-1013
- DOI
  10.1007/s00535-010-0247-z
- NAID
  10027699223
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590696
[Journal Article] MR enterocolonography is useful for simultaneous evaluation ofsmall and large intestinal lesions in Crohn's disease.2010
- Author(s)
  Hyun SB, Naganuma M, Watanabe M, et al.
- Journal Title
  
  Inflam Bowel Dis
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590696
[Journal Article] Safety and usefulness of balloon endoscopy in Crohn's disease patients with postoperative ileal lesions.2010
- Author(s)
  Naganuma M, Watanabe M, Hibi
- Journal Title
  
  J Crohn' s Colitis
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590696
[Journal Article] Novel endoscopic activity index is useful for choosing treatment in severe active ulcerative colitis patients2010
- Author(s)
  Naganuma M, Ichikawa H, Inoue N, Kobayashi T, Okamoto S, Hisamatsu T, Kanai T, Ogata H, Iwao Y, Hibi T
- Journal Title
  
  J Gastroenterol
  
  Volume: 45 Pages: 936-943
- DOI
  10.1007/s00535-010-0244-2
- NAID
  10027698991
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590696
[Journal Article] Conception outcomes and opinions about pregnancy for men with inflammatory bowel disease.2010
- Author(s)
  Sato A, Naganuma M, Watanabe ,M, et al.
- Journal Title
  
  Journal and Crohn's and Colitis
  
  Volume: 4 Pages: 183-188
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590696
[Presentation] 潰瘍性大腸炎に対するステロイド初期投与量および減量速度と治癒効果との関係2021
- Author(s)
  長沼誠
- Organizer
  第76回日本大腸肛門病学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08381
[Presentation] A step forward:proactive TDM2021
- Author(s)
  Naganuma M
- Organizer
  The 9th Annual Meeting of the Asian Organization for Crohn's and Colitis
- Invited
- Data Source
  KAKENHI-PROJECT-19K08381
[Presentation] IBDの最新治療新規薬剤登場により何が変わったか　潰瘍性大腸炎におけるTofacitinibとVedolizumabの治療の短期有効性の比較.2020
- Author(s)
  牟田口真, 長沼誠, 金井隆典.
- Organizer
  第106回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-18KK0246
[Presentation] 発赤領域として発見されESDにより確定診断されたUC関連平坦型dysplasiaの1例.2020
- Author(s)
  萩原裕也, 岩男泰, 牟田口真, 杉本真也, 南木康作, 三上洋平, 筋野智久, 前畑忠輝, 矢作直久, 下田将之, 長沼誠, 緒方晴彦, 金井隆典.
- Organizer
  第38回日本大腸検査学会総会
- Data Source
  KAKENHI-PROJECT-18KK0246
[Presentation] 難治性潰瘍性大腸炎に対するシクロスポリン持続静注療法の使用意義.2020
- Author(s)
  青木康浩, 福田知広, 吉松裕介, 南木康作, 三上洋平, 福原佳代子, 牟田口真, 筋野智久, 高林馨, 井上詠, 緒方晴彦, 岩男泰, 長沼誠, 金井隆典.
- Organizer
  第28回日本消化器関連学会週間
- Data Source
  KAKENHI-PROJECT-18KK0246
[Presentation] 炎症性腸疾患診療における内視鏡の役割　潰瘍性大腸炎に対してVedolizumab治療症例における内視鏡の役割.2020
- Author(s)
  牟田口真, 長沼誠, 福田知広, 緒方晴彦, 金井隆典.
- Organizer
  第110回日本消化器内視鏡学会関東支部例会
- Data Source
  KAKENHI-PROJECT-18KK0246
[Presentation] バルーン内視鏡による診断・治療の進歩　バルーン内視鏡によるクローン病の深部小腸病変評価の意義.2020
- Author(s)
  高林馨, 細江直樹, 長沼誠, 緒方晴彦, 金井隆典.
- Organizer
  第110回日本消化器内視鏡学会関東支部例会
- Data Source
  KAKENHI-PROJECT-18KK0246
[Presentation] 炎症性腸疾患に対する血球成分除去療法の新たな展開　難治性潰瘍性大腸炎患者に対するCAPの維持効果と安全性.2020
- Author(s)
  横山陽子, 長沼誠, 渡辺憲治, 金井隆典.
- Organizer
  第41回日本アフェレシス学会学術大会
- Data Source
  KAKENHI-PROJECT-18KK0246
[Presentation] 生薬『青黛』による潰瘍性大腸炎患者における寛解維持効果の検討と腸内細菌叢の解析.2020
- Author(s)
  吉松裕介, 筋野智久, 福田知広, 長沼誠, 金井隆典.
- Organizer
  第118回日本内科学会総会・講演会
- Data Source
  KAKENHI-PROJECT-18KK0246
[Presentation] 症性腸疾患診療のリアルワールド～生物学的製剤に対するクリニカルクエスチョンを解決する　実臨床におけるクローン病に対するウステキヌマブの有効性・安全性に関する検討2019
- Author(s)
  福田知広, 長沼誠, 金井隆典.
- Organizer
  日本消化器病学会
- Data Source
  KAKENHI-PROJECT-18KK0246
[Presentation] 潰瘍性大腸炎患者に対する青黛の現状の位置付け2019
- Author(s)
  杉本真也, 長沼誠, 福田知広, 南木康作, 水野慎大, 木村佳代子, 高林馨, 井上詠, 緒方晴彦, 岩男泰, 金井隆典
- Organizer
  日本消化管学会
- Data Source
  KAKENHI-PROJECT-18KK0246
[Presentation] Mayo内視鏡スコア1の潰瘍性大腸炎患者におけるインフリキシマブ使用の有無による再燃リスクの違いに関する検討.2019
- Author(s)
  福田知広, 長沼誠, 金井隆典.
- Organizer
  日本消化器内視鏡学会総会
- Data Source
  KAKENHI-PROJECT-18KK0246
[Presentation] 広範な潰瘍性病変を呈したアメーバ性大腸炎の一例.2019
- Author(s)
  津軽開, 高林馨, 南木康作, 野田まりん, 下嵜啓太郎, 林由紀恵, 平田賢郎, 福原佳代子, 三上洋平, 水野慎大, 加藤元彦, 正岡建洋, 細江直樹, 長沼誠, 緒方晴彦, 金井隆典
- Organizer
  日本消化器内視鏡学会関東支部例会
- Data Source
  KAKENHI-PROJECT-18KK0246
[Presentation] IBD関連腫瘍の診断および治療の現状と展望　潰瘍性大腸炎関連腫瘍に対する内視鏡治療例の検討2019
- Author(s)
  萩原裕也, 岩男泰, 長沼誠, 矢作直久, 金井隆典
- Organizer
  日本消化器内視鏡学会関東支部例会
- Data Source
  KAKENHI-PROJECT-18KK0246
[Presentation] ニボルマブ投与中に急性腸炎を発症した一例2019
- Author(s)
  佐藤萌, 脇坂悠介, 津軽開, 平田賢郎, 三上洋平, 水野慎大, 筋野智久, 須河恭敬, 浜本康夫, 高石官均, 長沼誠, 金井隆典, 前原純樹
- Organizer
  日本消化器病学会関東支部例会
- Data Source
  KAKENHI-PROJECT-18KK0246
[Presentation] Recent evidences and future perspect of indigo naturalis for ulcerative colitis.2018
- Author(s)
  Naganuma M et al
- Organizer
  Japan Digestive Disease Week 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09326
[Presentation] Indigo naturalis is effective in treatment-refractory patients with ulcerative colitis: Post-hoc analysis from INDIGO study.2018
- Author(s)
  Naganuma M et al
- Organizer
  American Gastroenterological Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09326
[Presentation] Indigo naturalis is effective for inducing clinical remission and mucosal healing in patients with ulcerative colitis. (INDIGO study).2017
- Author(s)
  Naganuma M et al
- Organizer
  United European Gastroenterology Week
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09326
[Presentation] gut-liver-brain axis によるマウス大腸炎抑制制御メカニズム2016
- Author(s)
  寺谷俊昭, 中本伸宏, 千葉明子, 鈴木貴博, 水野慎大, 長沼誠, 金井隆典
- Organizer
  第 53 回日本消化器免疫学会総会
- Place of Presentation
  ホテルニューオータニ大阪　大阪府大阪市
- Data Source
  KAKENHI-PROJECT-15H02534
[Presentation] カプセル化した青黛の潰瘍性大腸炎の寛解導入における有用性2016
- Author(s)
  杉本真也，長沼誠，金井隆典
- Organizer
  第102回日本消化器病学会総会
- Place of Presentation
  京王プラザホテル　東京都新宿区
- Data Source
  KAKENHI-PROJECT-15H02534
[Presentation] 炎症性腸疾患に対する外来ステロイド療法の有用性2016
- Author(s)
  牟田口真，長沼誠，金井隆
- Organizer
  第102回日本消化器病学会総会
- Place of Presentation
  京王プラザホテル　東京都新宿区
- Data Source
  KAKENHI-PROJECT-15H02534
[Presentation] エンドサイトを用いた潰瘍性大腸炎内視鏡的寛解例における組織学的活動度評価の意義2016
- Author(s)
  中里圭宏，長沼誠，金井隆典
- Organizer
  第102回日本消化器病学会総会
- Place of Presentation
  京王プラザホテル　東京都新宿区
- Data Source
  KAKENHI-PROJECT-15H02534
[Presentation] 治療抵抗性・難治性潰瘍性大腸炎に対する青黛の有用性2016
- Author(s)
  福田知広，長沼　誠，金井隆典
- Organizer
  第58回日本消化器病学会
- Place of Presentation
  神戸コンベンションセンター　兵庫県神戸市
- Data Source
  KAKENHI-PROJECT-15H02534
[Presentation] 内視鏡的活動期の潰瘍性大腸炎に対する治療介入が臨床経過と粘膜治癒に与える影響2016
- Author(s)
  大野恵子，長沼　誠，金井隆典
- Organizer
  第58回日本消化器病学会
- Place of Presentation
  神戸コンベンションセンター　兵庫県神戸市
- Data Source
  KAKENHI-PROJECT-15H02534
[Presentation] 潰瘍性大腸炎合併大腸癌・dysplasiaの内視鏡的危険因子の検討2015
- Author(s)
  金井隆典、長沼誠、岩男泰
- Organizer
  第101回日本消化器病学会
- Place of Presentation
  仙台国際センター宮城県仙台市
- Year and Date
  2015-04-25
- Data Source
  KAKENHI-PROJECT-15H02534
[Presentation] New drug development for inflammatory bowel disease in Japan: an example of collaboration among academia, industry, and government.2015
- Author(s)
  Katsuyoshi Matsuoka, Makoto Naganuma, Takanori Kanai
- Organizer
  第101回日本消化器病学会
- Place of Presentation
  仙台国際センター宮城県仙台市
- Year and Date
  2015-04-25
- Data Source
  KAKENHI-PROJECT-15H02534
[Presentation] クローン病生物学的製剤2次無効例に対する画像評価の有用性2015
- Author(s)
  中里圭宏、長沼誠、金井隆典
- Organizer
  第101回日本消化器病学会
- Place of Presentation
  仙台国際センター宮城県仙台市
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-15H02534
[Presentation] 炎症性腸疾患における腸内細菌の関与2015
- Author(s)
  水野慎大、南木康作、長沼誠、金井隆典
- Organizer
  第43回日本臨床免疫学会総会
- Place of Presentation
  神戸国際会議場兵庫県神戸市
- Year and Date
  2015-10-23
- Data Source
  KAKENHI-PROJECT-15H02534
[Presentation] 本邦におけるIBD患者の妊娠・出産の転帰に関する検討2011
- Author(s)
  長沼誠、渡辺守他
- Organizer
  日本消化器病学会総会
- Place of Presentation
  東京
- Year and Date
  2011-05-14
- Data Source
  KAKENHI-PROJECT-22590696
[Presentation] 潰瘍性大腸炎に対するTacrolimus持続静治療法の有用性2011
- Author(s)
  長沼誠
- Organizer
  第66回日本大腸肛門病学会学術集会
- Place of Presentation
  東京
- Year and Date
  2011-11-25
- Data Source
  KAKENHI-PROJECT-22590696
[Presentation] BD患者における風疹・麻疹・水痘・ムンプスに対する抗体価測定の意義2011
- Author(s)
  長沼誠、渡辺守, 他
- Organizer
  第15回日本消化器病学会総会
- Place of Presentation
  福岡
- Year and Date
  2011-10-20
- Data Source
  KAKENHI-PROJECT-22590696
[Presentation] Serological test and vaccinations for Measles, Mumps, Rubella, and Varicella Zoster deserve considerations as early as possible after diagnosis of Inflammatory Bowel Disease2011
- Author(s)
  Naganuma M, Watanabe M et al
- Organizer
  UEGW
- Place of Presentation
  ストックホルム
- Year and Date
  2011-10-25
- Data Source
  KAKENHI-PROJECT-22590696
[Presentation] 本邦におけるIBD患者の妊娠・出産の転帰に関する検討2011
- Author(s)
  長沼誠、渡辺守, 他
- Organizer
  第97回日本消化器病学会総会
- Place of Presentation
  東京
- Year and Date
  2011-05-14
- Data Source
  KAKENHI-PROJECT-22590696
[Presentation] Serological test and vaccinations for Measles, Mumps, Rubella, and Varicella Zoster deserve considerations as early as possible after diagnosis of Inflammatory Bowel Disease2011
- Author(s)
  Naganuma M, Watanabe M, et al
- Organizer
  UEGW2011
- Place of Presentation
  Stockholm
- Year and Date
  2011-10-25
- Data Source
  KAKENHI-PROJECT-22590696
[Presentation] 免疫調節薬・抗体製剤使用IBD患者におけるインフルエンザ感染症の現状2011
- Author(s)
  長沼誠、渡辺守他
- Organizer
  日本消化器病学会総会
- Place of Presentation
  東京
- Year and Date
  2011-05-13
- Data Source
  KAKENHI-PROJECT-22590696
[Presentation] 免疫調節薬・抗体製剤使用IBD患者におけるインフルエンザ感染症の現状2011
- Author(s)
  長沼誠、渡辺守, 他
- Organizer
  第97回日本消化器病学会総会
- Place of Presentation
  東京
- Year and Date
  2011-05-13
- Data Source
  KAKENHI-PROJECT-22590696
[Presentation] A Case of Refractory Ulcerative Colitis.2010
- Author(s)
  Naganuma M
- Organizer
  5th Japan-Korea IBD Symposium
- Place of Presentation
  Seoul
- Year and Date
  2010-10-02
- Data Source
  KAKENHI-PROJECT-22590696
[Presentation] 難治性潰瘍性大腸炎に対するCalcineurin inhibitorの位置づけ2010
- Author(s)
  藤井俊光、長沼越、玄世鋒、長堀正和、渡辺守
- Organizer
  第52回日本消化器病学会大会
- Place of Presentation
  横浜
- Year and Date
  2010-10-13
- Data Source
  KAKENHI-PROJECT-22590696
[Presentation] Conception and pregnancy outcome in women with inflammatory bouwel disease.2010
- Author(s)
  Naganuma M
- Organizer
  United European Gastroenterology week
- Place of Presentation
  Barcelona
- Year and Date
  2010-10-25
- Data Source
  KAKENHI-PROJECT-22590696
[Presentation] Infliximab時代における免疫調節剤の有用性2010
- Author(s)
  長沼誠、長堀正和、渡辺守
- Organizer
  第96回日本消化器病学会総会
- Place of Presentation
  新潟
- Year and Date
  2010-04-22
- Data Source
  KAKENHI-PROJECT-22590696
[Presentation] 難治性潰瘍性大腸炎に対するタクロリムス初期投与量と血中トラフ値の推移の検討(多施設協同研究)2010
- Author(s)
  長沼誠、渡辺守
- Organizer
  第52回日本消化器病学会大会
- Place of Presentation
  横浜
- Year and Date
  2010-10-14
- Data Source
  KAKENHI-PROJECT-22590696
[Presentation] Intravenous tacrolimus therapy can rapidly induce remission in refractory.
- Author(s)
  Fujii T, Naganuma M, Nagahori M, Watanabe M et al.
- Organizer
  Digestive Disease Week 2012
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-22590696
[Presentation] 抗体製剤使用炎症性腸疾患患者における血中濃度測定と中和抗体測定の意義
- Author(s)
  藤井俊光、長沼　誠、渡辺　守
- Organizer
  第98回日本消化器病学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590696
[Presentation] MR enterocolonography (MREC)の実際とクローン病小腸大腸病変の評価における有用性
- Author(s)
  藤井俊光、長沼誠、渡辺　守　他
- Organizer
  第30回日本大腸検査学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590696
[Presentation] 難治性潰瘍性大腸炎に対するTacrolimus静注療法の有用性と安全性の検討
- Author(s)
  藤井俊光、長堀正和、長沼誠、渡辺　守、他
- Organizer
  第98回日本消化器病学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590696
[Presentation] 炎症性腸疾患患者における抗TNFa受容体拮抗薬の選択に関する研究
- Author(s)
  長堀正和、長沼誠、渡辺　守、他
- Organizer
  第98回日本消化器病学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590696

1. KANAI TAKANORI (40245478)

# of Collaborated Projects: 3 results

# of Collaborated Products: 58 results
2. HIBI Toshifumi (50129623)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. WATANABE Mamoru (10175127)

# of Collaborated Projects: 2 results

# of Collaborated Products: 34 results
4. 寺谷俊昭 (40624408)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
5. NAGISHI Takashi (60447464)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. FUNAKOSHI Shinsuke (20297352)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 新井潤 (30306683)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 久松理一 (60255437)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
9. 杉本真也 (20626387)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. 山敷宣代 (90420215)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 村田美樹 (10533416)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 池田俊一郎 (40772231)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. Mizuno Shinta

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
14. HIRAYAMA Akiyoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. NAKASE Hiroshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
16. SHIMIZU Mikiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. HASHIGUCHI Masayuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. SUZUKI Shinji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. ARAKI Akihiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. TAMURA Yuichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 阿部貴行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 筋野智久

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
23. 竹中健人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 長堀正和

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
25. 土屋輝一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 岡田英理子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 藤井俊光

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
28. 佐藤俊朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 細江直樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
30. 高林馨

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 岩男泰

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
32. 緒方晴彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. 三上修治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 水野隆一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 鈴木英雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Naganuma Makoto 長沼 誠

NAGANUMA Makoto 長沼 誠

Research Projects

Research Products

Co-Researchers

活性化血小板をターゲットとした炎症性腸疾患バイオマーカー同定と新規治療法の開発Principal Investigator

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禁酒継続に向け医療者ー患者双方向を支援するデジタルヘルス環境の構築

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Analysis of intestinal and oral bacterial flora in patients with ulcerative colitis aimed for optimization of treatmentPrincipal Investigator

Principal Investigator

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The elucidation of the World of AhR in the intestinal environment ,followed by the diverse clinical applications.

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Investigation of the mechanisms for inhibitory effects on colonic inflammation and cancer of indigo naturalis including indole compoundsPrincipal Investigator

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To identify the mechanism of inflammatory bowel disease by using human microbe mono-associated mouse

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Identification of the inflammatory signaling in intestinal epithelial cells involvedPrincipal Investigator

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遺伝子多型性の解析に基づいた炎症性腸疾患に対する新しい免疫抑制剤投与法の開発Principal Investigator

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New therapy targeting IL-7 receptor positive lymphocytes for chronic intestinal inflammationPrincipal Investigator

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[Book] Japanese Journal of Clinical Immunology2012

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[Book] Intestine2012

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[Book] Medical Practice2012

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[Book] 免疫調節薬(炎症性腸疾患)2010

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Total Pages

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Data Source

[Book] 日本消化器病学会雑誌(クローン病小腸病変の診断と治療)1072010

Author(s)

Naganuma Makoto 長沼誠

NAGANUMA Makoto 長沼誠