AISO Sadakazu 相磯貞和

Researcher Number	60138013
Other IDs
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Affiliation (based on the past Project Information) *help	2009 – 2015: Keio University, 医学部, 教授 2001 – 2005: 慶應義塾大学, 医学部, 教授 1992 – 1999: 慶應義塾大学, 医学部, 教授 1997: Keio University, School of Medicine, Professor, 医学部, 教授 1988 – 1991: 慶應義塾大学, 医学部, 講師 … More 1990: 慶応義塾大学, 医学部, 講師 1988: Assistant professor, Dept. of Anat., Sch. of Med., Keio Univ., 医学部, 講師 1987: 慶應義塾大学, 医学部, 専任講師 1986: 慶應義塾大学, 医学部, 講師 Less
Review Section/Research Field	Principal Investigator General anatomy (including Histology/Embryology) / General anatomy (including Histology/Embryology) Except Principal Investigator General anatomy (including Histology/Embryology) / Gastroenterology / Physical pharmacy
Keywords	Principal Investigator xenopus / paxillin / cDNA / HLA-DQ / プロラクチン / トランスジェニックマウス / signal transduction molecules / oligodendroglia / myelination / 情報伝達関連分子 … More / 情報伝達関連連分子 / 髄鞘形成 / オリゴデンドログリア / cell cycle / リン酸化 / アフリカツメガエル / 細胞周期 / パキシリン / ENHANCER OF ZESTE / HOMEOTIC GENE / DEVELOPMENT / POLYCOMB GENE / E(z)ホモローグ / 神経 / Enhancer of zeste / ホメオティック遺伝子 / 発生 / ポリコーム遺伝子 / PROLACTIN RECEPTOR / IN SITU PCR / IMMUNOHISTOCHEMISTRY / GENE EXPRESSION / PROLACTION / ホルモン / 脳室 / 組織化学 / PCR / in situ RT / プロラクチン受容体 / in situ PCR / 免疫組織化学 / 遺伝子発現 / Immunoregulation / transugenic mouse / 免疫応答調節機構 / placenta / transgenic mice / prolactin / 発現制御因子 / 胎盤 / セリンラセメース / 形態形成 / 腎不全 / 肝不全 / 神経変性疾患 / D-セリン / 形態形成学 / 発生学 … More Except Principal Investigator HIV / IL-7 / AIDS / モノクローナル抗体 / CD4 / 細胞障害性T細胞 / エイズ / ラット / 免疫組織化学 / 光学分割 / アミノ酸 / 分析化学 / In vitro transcription / Northern blot analysis / In situ hybridization / gamma-GTP / ノザンハイブリダイゼーション / γ-glutamyl transpeptidase / Northern hybridization / in vitro transcription / γ-GTP / in situ hybridization / Monoclonal antibodies / GST- / r-GTP / Oncofetal enzymes / ガンマグルタミルトランスペプチダーゼ / ガンマグルタシルトランスペプチダーゼ / グルタチオンSトランスフェラーゼ / FLAP / ANGIOGRAPHY / THREE-DIMENSION / VEIN / ARTERY / VASCULAR ANATOMY / SUBCUTANEOUS TISSU / SKIN / 3次元 / 皮弁 / 血管造影 / 三次元 / 静脈 / 動脈 / 血管解剖 / 皮下組織 / 皮膚 / Cholera toxin / cytotoxic Tlymphcyte / transgenic mouse / mucosal immunology / oral Immunization / SIV / コレラトキシン / トランスジェニックマウス / 腸管免疫 / 経口免疫 / SOLUBLE CD4 / MONOCLONAL ANTIBODY / CYTOTOXIC T LYMPHOCYTE / INTESTINAL MUCOSAL LYMPHOCYTE / 腸管上皮間リンパ球 / 可溶性CD4 / 腸管粘膜内リンパ球 / Rabbit / Rat / Immunoelectron microscopy / Recycling of secretory granule membrane / Immunohistochemistry / Monoclonal antibody / Common antigens of secretory granule membrane / 分泌果粒共通抗原 / ウサギ / 免疫電顕 / 分泌顆粒膜のリサイクリング / モノクロナ-ル抗体 / 分泌顆粒膜共通抗原 / メタボロミクス / メタボローム / メタレベル / 情報システム / マルチメディアデータベース / データベース統合 / 知識ベース / メタデータベース / データベース Less

Early diagnosis of the defect in amino acid metabolism using chiral amino acid metabolomics
- Principal Investigator
  
  Kenji Hamase
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kyushu University
Development of an enantioselective amino acid metabolome analysismethod and its clinical applications
- Principal Investigator
  
  HAMASE Kenji
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kyushu University
Morphogenetic regulation through D-serine/serine racemasePrincipal Investigator
- Principal Investigator
  
  AISO Sadakazu
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Keio University
The key molecules in signal transduction in the process of oligodendroglia myelinationPrincipal Investigator
- Principal Investigator
  
  AISO Sadakazu
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Keio University
CLARIFICATION OF THREE-DIMENSIONAL ARCHITECTURE OF ARTERIES AND VEINS IN THE SKIN AND SUBCUTANEOUS TISSUE
- Principal Investigator
  
  IMANISHI Nobuaki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  KEIO UNIVERSITY
人文社会科学と自然科学を連携するメタレベル知識ベースシステムの開発
- Principal Investigator
  
  清木康
- Project Period (FY)
  2001 – 2005
- Research Category
  
  Grant-in-Aid for Creative Scientific Research
- Research Institution
  Keio University
Elucidation of the molecular functions of paxillin in cell cyclesPrincipal Investigator
- Principal Investigator
  
  AISO Sadakazu
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Keio University
FUNCTIONAL ANALYSIS OF A MAMMALIAN DEVELOPMENT-ASSOCIATED GENE, E(z)HOMOLOGPrincipal Investigator
- Principal Investigator
  
  AISO Sadakazu
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Keio University
EXPRESSION OF THE PROLACTIN GEGE IN VARIOUS TISSUES AND ITS FUNCTIONSPrincipal Investigator
- Principal Investigator
  
  AISO Sadakazu
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  KEIO UNIVERSITY
Preparation and analysis of transgenic mice with fuman HLA-DQ genesPrincipal Investigator
- Principal Investigator
  
  AISO Sadakazu
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Keio University
Induction of cytotoxic Tlymphocyters in the intestinal mucosa by oral immunization of SIV gag or env peptide conjugated with chorela toxin
- Principal Investigator
  
  HIBI Toshifumi, 渡辺守
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University
ACTIVE IMMUNE THERAPY FOR THE TREATMENT OF AIDS
- Principal Investigator
  
  WATANABE Mamoru
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  KEIO UNIVERSITY
Study of a placenta-specific promoter of human prolactin with transgenic micePrincipal Investigator
- Principal Investigator
  
  AISO Sadakazu
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Keio University
Synthesis and Intracellular Transport of Common Antigens of Secretory Granule Membrane.
- Principal Investigator
  
  YAMASHITA Shuji
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Keio University, School of Medicine, Department of Anatomy
In situ hybridization using synthetic probe.
- Principal Investigator
  
  YASUDA Kenjiro
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Department of Anatomy, School of Medicine, Keio University Shinanomachi-35, Shinjuku, Tokyo
Immunohistochemical study of enzymes using monoclonal antibodies: Oncofetal enzymes.
- Principal Investigator
  
  YASUDA Kenjiro
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Department of Anatomy, School of Medicine, Keio University, Shinanomach-35, Shinjuku, Tokyo

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All Journal Article Presentation Book Other

[Book] 「D-セリンと中枢神経機能」Annual Review神経20122012
- Author(s)
  笹部潤平、相磯貞和
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-21249009
[Book] D-セリンと中枢神経機能. Annual Review神経20122012
- Author(s)
  笹部潤平、相磯貞和
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-21249009
[Journal Article] Ischemic acute kidney injury perturbs homeostasis of serine enantiomers in the body fluid in mice: early detection of renal dysfunction using the ratio of serine enantiomers2014
- Author(s)
  Jumpei SASABE, Masataka SUZUKI, Yurika MIYOSHI, Yosuke TOJO, Chieko OKAMURA, Sonomi ITO, Ryuichi KONNO, Masashi MITA, Kenji HAMASE, Sadakazu AISO
- Journal Title
  
  PLoS ONE
  
  Volume: 9 Issue: 1 Pages: e86504-e86504
- DOI
  10.1371/journal.pone.0086504
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293007
[Journal Article] D-Ser-containing humanin shows promotion of fibril formation2012
- Author(s)
  Kanehiro Hayashi, Jumpei Sasabe, Tomohiro Chiba, Sadakazu Aiso, Naoko Utsunomiya-Tate
- Journal Title
  
  Amino Acids
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249009
[Journal Article] D-amino acid oxidase controls motoneuron degeneration through D-serine2012
- Author(s)
  Jumpei Sasabe, Yurika Miyoshi, Masataka Suzuki, Masashi Mita, Ryuichi Konno, Masaaki Matsuoka, Kenji Hamase, Sadakazu Aiso
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 109 Pages: 627-32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249009
[Journal Article] Type 1 diabetes mellitus in mice increases hippocampal D-serine in the acute phase after streptozotocin injection.2012
- Author(s)
  Masataka Suzuki
- Journal Title
  
  Brain Res.
  
  Volume: 1466 Pages: 167-176
- DOI
  10.1016/j.brainres.2012.05.042
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22380078, KAKENHI-PROJECT-22390007
[Journal Article] Current concepts in multiple sclerosis : autoimmunity versus oligodendrogliopathy2012
- Author(s)
  Nakahara J, Maeda M, Aiso S, Suzuki N
- Journal Title
  
  Clin Rev Allergy Immunol
  
  Volume: 42 Issue: 1 Pages: 26-34
- DOI
  10.1007/s12016-011-8287-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249009, KAKENHI-PROJECT-22689028
[Journal Article] Alteration of intrinsic amounts of D-serine in tne mice lacking serine racemase and D-amino acid oxidase2012
- Author(s)
  Yurika MIYOSHI, et al.
- Journal Title
  
  Amino Acids
  
  Volume: 43 Issue: 5 Pages: 1919-1931
- DOI
  10.1007/s00726-012-1398-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J07562, KAKENHI-PROJECT-22390007
[Journal Article] D-Amino acid oxidase controls motoneuron degeneration through D-serine2012
- Author(s)
  Jumpei SASABE, et al
- Journal Title
  
  Proceedings of the National Academy of Sciences of the United States of America
  
  Volume: 109 Issue: 2 Pages: 627-632
- DOI
  10.1073/pnas.1114639109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J07562, KAKENHI-PROJECT-21249009, KAKENHI-PROJECT-22390007, KAKENHI-PROJECT-22790828
[Journal Article] Structural requirements for activation in alphaIIb beta3 integrin2010
- Author(s)
  Kamata T, etc., Aiso S
- Journal Title
  
  J.Biol.Chem.
  
  Volume: 285 Pages: 38428-37
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249009
[Journal Article] Aberrant control of motoneuronal excitability in amyotrophic lateral sclerosis : excitatory glutamate/D-serine vs.inhibitory glycine/gamma-aminobutanoic acid(GABA)2010
- Author(s)
  Sasabe J, Aiso S
- Journal Title
  
  Chem.Biodivers.
  
  Volume: 7 Pages: 1479-90
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249009
[Journal Article] Aberrant control of motoneuronal excitability in amyotrophic lateral sclerosis : excitatory glutamate/D-serine vs. inhibitory glycine/gamma-aminobutanoic acid(GABA)2010
- Author(s)
  Jumpei Sasabe, Sadakazu Aiso
- Journal Title
  
  Chem Biodivers
  
  Volume: 7 Pages: 1479-90
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249009
[Journal Article] Structural requirements for activation in alphaIIb beta3 integrin2010
- Author(s)
  Kamata T, Handa M, Ito S, Sato Y, Ohtani T, Kawai Y, Ikeda Y, Aiso S
- Journal Title
  
  J Biol Chem
  
  Volume: 285 Pages: 38428-37
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249009
[Journal Article] Aberrant control of motoneuronal excitation in Amyotrophic Lateral Sclerosis : excitatory glutamate/D-serine vs.inhibitory glycine/GABA2010
- Author(s)
  笹部潤平, 相磯貞和
- Journal Title
  
  Chemistry and biodiversity (未定, In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249009
[Journal Article] D-Serine in the pathogenesis of amyotrophic lateral sclerosis2010
- Author(s)
  Jumpei Sasabe, Sadakazu Aiso
- Journal Title
  
  Seikagaku
  
  Volume: 82 Pages: 628-32
- Data Source
  KAKENHI-PROJECT-21249009
[Journal Article] Autoimmune versus oligodendrogliopathy : the pathogenesis of multiple sclerosis2010
- Author(s)
  Nakahara J, Aiso S, Suzuki N
- Journal Title
  
  Arch.Immunol.Ther.Exp.
  
  Volume: 58 Pages: 325-33
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249009
[Journal Article] 筋萎縮性側索硬化症におけるD-セリン2010
- Author(s)
  笹部潤平, 相磯貞和
- Journal Title
  
  日本生化学会誌 (未定, In press)
- NAID
  10026607702
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249009
[Journal Article] Targeting the JAK2/STAT3 axis in Alzheimer's disease2009
- Author(s)
  T.Chiba, M.Yamada, S.Aiso
- Journal Title
  
  Expert Opin.Ther.Targets 13
  
  Pages: 1155-1167
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249009
[Journal Article] Abnormal expression of TIP30 and arrested nucleocytoplasmic transport within oligodendrocyte precursor cells in multiple sclerosis2009
- Author(s)
  Nakahara J, Kanekura K, Nawa M, Aiso S, Suzuki N
- Journal Title
  
  J Clin Invest
  
  Volume: 119 Pages: 169-81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249009
[Journal Article] Fc receptor-positive cells in remyelinating multiple sclerosis lesions2006
- Author(s)
  Nakahara J, Aiso S.
- Journal Title
  
  J Neuroopath Exp Neurol (In press)
- Data Source
  KAKENHI-PROJECT-16390050
[Journal Article] Transforming growth factor beta2 autocrinally mediates neuronal cell death induced by amyloid-beta.2006
- Author(s)
  Hashimoto Y, Nawa M, Chiba T, Aiso S, Nishimoto I, Matsuoka M.
- Journal Title
  
  J Neurosci Res. 83(6)
  
  Pages: 1039-1047
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390050
[Journal Article] Fc receptor-positive cells in remyelinating multiple sclerosis lesions.2006
- Author(s)
  Nakahara J, Aiso S.
- Journal Title
  
  J Neuropathol Exp Neurol. 65(6)
  
  Pages: 582-591
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390050
[Journal Article] Colivelin prolongs survival of an ALS model mouse.2006
- Author(s)
  Chiba T, Yamada M, Sasabe J, Terashita K, Aiso S, Matsuoka M, Nishimoto I.
- Journal Title
  
  Biochem Biophys Res Commun. 343(3)[Epub 2006 Mar 10]
  
  Pages: 793-798
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390050
[Journal Article] Fc receptor positive cells in remyelinating multiple sclerosis lesions.2006
- Author(s)
  Nakahara J., Aiso S.
- Journal Title
  
  J Neuropathol Exp Neurol 65・9
  
  Pages: 582-91
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390050
[Journal Article] Demyelination and remyelination in multiple sclerosis lesion (in Japanese)2006
- Author(s)
  Nakahara J, Aiso S
- Journal Title
  
  Seitai no Kagaku 57(3)
  
  Pages: 203-212
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390050
[Journal Article] Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus : characterization of colivelin-mediated neuroprotection against Alzheimer's disease-relevant insults in vitro and in vivo.2005
- Author(s)
  Chiba T, Yamada M, Hashimoto Y, Sato M, Sasabe J, Kita Y, Terashita K, Aiso S, Nishimoto I, Matsuoka M.
- Journal Title
  
  J Neurosci. 25(44)
  
  Pages: 10252-10261
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390050
[Journal Article] Transforming growth factor beta2 is a neuronal death-inducing ligand for amyloid-beta precursor protein2005
- Author(s)
  Hashimoto Y, Chiba T, Yamada M, Nawa M, Kanekura K, Suzuki H, Terashita K, Aiso S, Nishimoto I, Matsuoka M.
- Journal Title
  
  Mol Cell Biol. 25(21)
  
  Pages: 9304-9317
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390050
[Journal Article] 多発性硬化症における脱随と髄鞘再生2005
- Author(s)
  中原仁, 相磯貞和
- Journal Title
  
  生体の科学 57・3
  
  Pages: 203-12
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390050
[Journal Article] Membrane-proximal {alpha}/{beta} stalk interactions differentially regulate integrin activation2005
- Author(s)
  Kamata T, Handa M, Sato Y, Ikeda Y, Aiso S.
- Journal Title
  
  J Biol Chem. 280(26)[Epub 2005 Apr 29]
  
  Pages: 24775-24783
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390050
[Journal Article] A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu-Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death2005
- Author(s)
  Kanekura K., Hashimoto Y., Kita Y., Sasabe J., Aiso S., Nishimoto I., Matsuoka M.
- Journal Title
  
  J Biol Chem 280(6)
  
  Pages: 4532-4543
- Data Source
  KAKENHI-PROJECT-13GS0020
[Journal Article] A humanin derivative, S14G-HN, prevents amyloid-beta-induced memory impairment in mice2005
- Author(s)
  Tajima H., Kawasumi M., Shiba T., Yamada M., Yamashita K., Nawa M., Kita Y., Kouyama K., Aiso S., Matsuoka M., Niikura T.
- Journal Title
  
  J Neurosci Res. 79(5)
  
  Pages: 714-723
- Data Source
  KAKENHI-PROJECT-13GS0020
[Journal Article] Involvement of tyrosine kinases and STAT3 in Humanin-mediated neuroprotection.2005
- Author(s)
  Hashimoto Y, Suzuki H, Aiso S, Niikura T, Nishimoto I, Matsuoka M.
- Journal Title
  
  Life Sci. 77(24)[Epub 2005Jul 6]
  
  Pages: 3092-3104
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390050
[Journal Article] Involvement of CD45 in central nervous system myelination.2005
- Author(s)
  Nakahara J, Seiwa C, Tan-Takeuchi K, Gotoh M, Kishihara K, Ogawa M, Asou H, Aiso S.
- Journal Title
  
  Neurosci Lett. 379(2)[Epub 2005 Jan 21]
  
  Pages: 116-121
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390050
[Journal Article] Involvement of CD45 in central nervous system myelination2005
- Author(s)
  Nakahara J, Seiwa C, Tan-Takeuchi K, Gotoh M, Kishihara K, Ogawa M, Asou H, Aiso S.
- Journal Title
  
  Neurosci Lett 379・2
  
  Pages: 116-121
- Data Source
  KAKENHI-PROJECT-16390050
[Journal Article] SNPおよび臨床データベースを対象としたハプロタイプ解析による知識発見方式2005
- Author(s)
  吉田尚史, 清木康, 藤島清太郎, 相磯貞和
- Journal Title
  
  日本データベース学会Letters Vol.3,No.4(Accepted)
- NAID
  40007013126
- Data Source
  KAKENHI-PROJECT-13GS0020
[Journal Article] Implanted cannula-mediated repetitive administration of Abeta25-35 into the mouse cerebral ventricle effectively impairs spatial working memory.2005
- Author(s)
  Yamada M, Chiba T, Sasabe J, Nawa M, Tajima H, Niikura T, Terashita K, Aiso S, Kita Y, Matsuoka M, Nishimoto I.
- Journal Title
  
  Behav Brain Res. 164(2)
  
  Pages: 139-146
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390050
[Journal Article] Expression of N19S-SOD1, an SOD1 mutant found in sporadic amyotrophic lateral sclerosis patients, induces low-grade motoneuronal toxicity.2005
- Author(s)
  Obata Y, Niikura T, Kanekura K, Hashimoto Y, Kawasumi M, Kita Y, Aiso S, Matsuoka M, Nishimoto I.
- Journal Title
  
  J Neurosci Res. 81(5)
  
  Pages: 720-729
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390050
[Journal Article] Neuroprotective effect of activity-dependent neurotrophic factor against toxicity from familial amyotrophic lateral sclerosis-linked mutant SOD1 in vitro and in vivo2004
- Author(s)
  Chiba T., Hashimoto Y., Tajima H., Yamada M., Kato R., Nishikura T., Terashita K., Schulman H., Aiso S., Kita Y., Matsuoka M., Nishimoto I.
- Journal Title
  
  J Neurosci Res. 78(4)
  
  Pages: 542-552
- Data Source
  KAKENHI-PROJECT-13GS0020
[Journal Article] Characterization of V6421-AbetaPP-induced cytotoxicity in primary neurons2004
- Author(s)
  Niikura T., Yamada M., Chiba T., Aiso S., Matsuoka M., Nishimoto I.
- Journal Title
  
  J Neurosci Res. 77(1)
  
  Pages: 54-62
- Data Source
  KAKENHI-PROJECT-13GS0020
[Journal Article] Anatomical study of subcutaneous adipofascial tissue: a concept of the protective adipofascial system (PAFS) and lubricant adipofascial system (LAFS)2004
- Author(s)
  nakajima H., Imanishi N., Minabe T., Kishi K., Aiso S.
- Journal Title
  
  Scand J Plast Reconstr Surg Hand Surg. 38(5)
  
  Pages: 261-266
- Data Source
  KAKENHI-PROJECT-13GS0020
[Journal Article] Humanin antagonists: mutants that interfere with dimerization inhibit neuroprotection by Humanin2004
- Author(s)
  Hashimoto Y., Terashita K., Niikura T., Yamagishi Y., Ishizaka M., Kanekura K., Chiba T., yamada m., Kita Y., Aiso S., Matsuoka M., Nishimoto I.
- Journal Title
  
  Eur J Neurosci. 19(9)
  
  Pages: 2356-2364
- Data Source
  KAKENHI-PROJECT-13GS0020
[Journal Article] Targeted introduction of V6421 mutation in amyloid precursor protein gene causes functional abnormality resembling early stage of Alzheimer's disease in aged mice2004
- Author(s)
  Kawasumi M., Chiba T., Yamada M., Miyamae-Kaneko M., Matsuoka M., Nakahara J., Tomita T., Iwatsubo T., Kato S., Aiso S., Nishimoto I., Kouyama K.
- Journal Title
  
  Eur J Neurosci. 19(10)
  
  Pages: 2826-2838
- Data Source
  KAKENHI-PROJECT-13GS0020
[Journal Article] The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression2004
- Author(s)
  Suzuki H., Kurita M., Mizumoto K., Moriyama M., Aiso S., Nishimoto I., Matsuoka M.
- Journal Title
  
  Biochem Biophys Res Commun. 326(1)
  
  Pages: 242-248
- Data Source
  KAKENHI-PROJECT-13GS0020
[Journal Article] Overexpression of CR/periphilin downregulates Cdc7 expression and induces S-phase arrest2004
- Author(s)
  Kurita M., Suzuki H., Masai H., Mizumoto K., Ogata E., Nishimoto I., Aiso S., Matsuoka M.
- Journal Title
  
  Biochem Biophys Res Commun. 324(2)
  
  Pages: 554-561
- Data Source
  KAKENHI-PROJECT-13GS0020
[Journal Article] Arterial anatomy of the lower lip2004
- Author(s)
  Kawai K., Imanishi N., Nakajima H., Aiso S., Kakibuchi M., Hosokawa K.
- Journal Title
  
  Scand J Plast Reconstr Surg Hand Surg. 38(3)
  
  Pages: 135-139
- Data Source
  KAKENHI-PROJECT-13GS0020
[Journal Article] CCL22 and CCL17 in rat radiation pneumonitis and in human idiopathic pulmonary fibrosis2004
- Author(s)
  Inoue T., Fujishima S., Ikeda E., Yoshie O., Tsukamoto N., Aiso S., Aikawa N., Kubo A., Matsushima K., Yamaguchi K.
- Journal Title
  
  Eur Respir J. 24(1)
  
  Pages: 49-56
- Data Source
  KAKENHI-PROJECT-13GS0020
[Journal Article] Alsin, the product of ALS2 gene, Suppresses SOD1 mutant neurotoxicity through RhoGEF domain by interacting with SOD1 mutants2004
- Author(s)
  Kanekura K., Hashimoto Y., Niikura T., Aiso S., Matsuoka M., Nishimoto I.
- Journal Title
  
  J Biol Chem. 279(18)
  
  Pages: 19247-19256
- Data Source
  KAKENHI-PROJECT-13GS0020
[Journal Article] Humanin: after the discovery2004
- Author(s)
  Niikura T., Chiba T., Aiso S., Matsuoka M., Nishimoto I.
- Journal Title
  
  Mol Neurobiol. 30(3)
  
  Pages: 327-340
- Data Source
  KAKENHI-PROJECT-13GS0020
[Journal Article] Cytotoxic mechanisms by M230V presenilin 2, a little-analyzed Alzheimer's disease-causative mutant2004
- Author(s)
  Abe Y., Hashimoto Y., Tomita Y., Terashita K., Aiso S., Tajima H., Niikura T., Matsuoka M., Nishimoto I.
- Journal Title
  
  J Neurosci Res. 77(4)
  
  Pages: 583-595
- Data Source
  KAKENHI-PROJECT-13GS0020
[Journal Article] Vascular anatomy of the anterolateral thigh flap2004
- Author(s)
  Kawai K., Imanishi N., Nakajima H., Aiso S., Kakibuchi M., Hosokawa K.
- Journal Title
  
  Plast Reconstr Surg. 114(5)
  
  Pages: 1108-1117
- Data Source
  KAKENHI-PROJECT-13GS0020
[Journal Article] Molecular characterization of neurohybrid cell death induced by Alzheimer's amyloid-beta peptides via p75NTR/PLAIDD2004
- Author(s)
  Hashimoto Y., Kaneko Y., Tsukamoto E., Furankowski H., Kouyama K., Kita Y., Niikura T., Aiso S., Bredesen DE., Matsuoka M., Nishimoto I
- Journal Title
  
  J Neurochme. 90(3)
  
  Pages: 549-558
- Data Source
  KAKENHI-PROJECT-13GS0020
[Presentation] Chiral amino acid targeted metabolomics for clinical diagnosis using enantioselective two-dimensional HPLC tandem-mass spectrometry2015
- Author(s)
  Kenji HAMASE, Yurika MIYOSHI, Yayoi YONENAGA, Hirohisa ONIGAHARA, Yusuke ITO, Masashi MITA, Jumpei SASABE, Sadakazu AISO, Wolfgang LINDNER
- Organizer
  42nd International Symposium on High Performance Liquid Phase Separations and Related Techniques
- Place of Presentation
  Geneva, Switzerland
- Year and Date
  2015-06-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293007
[Presentation] 定量的キラルアミノ酸メタボロミクスの推進を可能とする二次元HPLC法の開発2013
- Author(s)
  浜瀬健司，三次百合香，三田真史，笹部潤平，相磯貞和
- Organizer
  第8回メタボロームシンポジウム
- Place of Presentation
  福岡
- Invited
- Data Source
  KAKENHI-PROJECT-25293007
[Presentation] Chiral amino acid metabolome analysis for biomarker assay in clinical diagnosis using enantioselective 2D-HPLC2013
- Author(s)
  Kenji HAMASE, Yurika MIYOSHI, Nao KUSANO, Jumpei SASABE, Yosuke TOJO, Masashi MITA, Sadakazu AISO, Wolfgang LINDNER
- Organizer
  39th International Symposium on High-Performance Liquid Phase Separations and Related Techniques
- Place of Presentation
  Amsterdam
- Data Source
  KAKENHI-PROJECT-25293007
[Presentation] キラルアミノ酸メタボロミクスによる疾患バイオマーカー探索への新しいアプローチ2013
- Author(s)
  浜瀬健司，三次百合香，笹部潤平，木村友則，山本陵平，三田真史，猪阪善隆，相磯貞和
- Organizer
  第38回日本医用マススペクトル学会年会
- Place of Presentation
  神戸
- Invited
- Data Source
  KAKENHI-PROJECT-25293007
[Presentation] 新規セリンラセマーゼ結合分子の同定と機能解析2011
- Author(s)
  Suzuki M, Aiso S
- Organizer
  D-アミノ酸学会
- Place of Presentation
  東京医科歯科大学M&Dタワー(東京都)
- Year and Date
  2011-09-10
- Data Source
  KAKENHI-PROJECT-21249009
[Presentation] 運動神経路におけるD-セリンと運動神経変性2011
- Author(s)
  Sasabe J, Aiso S
- Organizer
  D-アミノ酸学会
- Place of Presentation
  東京医科歯科大学M&Dタワー(東京都)
- Year and Date
  2011-09-10
- Data Source
  KAKENHI-PROJECT-21249009
[Presentation] Quantitative analyses of D-/L-serine in mice model for amyotrophic laterat sclerosis2009
- Author(s)
  J.Sasabe, Y Miyoshi, K.Hamase, T.Chiba, M.Suzuki, M.Yamada, M.Matsuoka, K.Zaitsu, S.Aiso
- Organizer
  北米神経科学会
- Place of Presentation
  シカゴ、USA
- Year and Date
  2009-10-20
- Data Source
  KAKENHI-PROJECT-21249009
[Presentation] Chiral amino acid metabolomics using two-dimensional HPLC for novel biomarker screening
- Author(s)
  Kenji HAMASE, Yurika MIYOSHI, Jumpei SASABE, Tomonori KIMURA, Masashi MITA, Ryohei YAMAMOTO, Yoshitaka ISAKA, Sadakazu AISO, Wolfgang LINDNER
- Organizer
  30th International Symposium on Chromatography
- Place of Presentation
  Salzburg
- Year and Date
  2014-09-14 – 2014-09-18
- Invited
- Data Source
  KAKENHI-PROJECT-25293007
[]

1. SHOZAWA Masahide (50170840)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. OGAWA Motoyuki (90255422)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. YAMASHITA Shuji (90050666)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. YASUDA Kenjiro (90050327)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. HIRAOKA Yoshiki (80218768)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. WATANABE Mamoru (10175127)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. HIBI Toshifumi (50129623)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. HAMASE Kenji (10284522)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
9. KOYANAGI Satoru (60330932)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. UEDA Tadashi (90184928)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. SASABE Jumpei (10398612)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
12. ENDO Fumio (00176801)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. ISHII Hiromasa (20051500)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. IMANISHI Nobuaki (00184820)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. NAKAJIMA Hideo (50129558)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. KAMATA Tetsuji (00185969)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. 清木康 (10169956)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. 徳田英幸 (80227579)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 金子郁容 (70169564)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
20. 古川康一 (10245615)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 武藤佳恭 (40245618)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

AISO Sadakazu 相磯 貞和

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Morphogenetic regulation through D-serine/serine racemasePrincipal Investigator

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The key molecules in signal transduction in the process of oligodendroglia myelinationPrincipal Investigator

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Elucidation of the molecular functions of paxillin in cell cyclesPrincipal Investigator

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FUNCTIONAL ANALYSIS OF A MAMMALIAN DEVELOPMENT-ASSOCIATED GENE, E(z)HOMOLOGPrincipal Investigator

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EXPRESSION OF THE PROLACTIN GEGE IN VARIOUS TISSUES AND ITS FUNCTIONSPrincipal Investigator

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Preparation and analysis of transgenic mice with fuman HLA-DQ genesPrincipal Investigator

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Study of a placenta-specific promoter of human prolactin with transgenic micePrincipal Investigator

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AISO Sadakazu 相磯貞和