Murakami Kazuma 村上一馬

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MURAKAMI Kazuma 村上一馬

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Researcher Number	80571281
Other IDs	https://orcid.org/0000-0003-3152-1784
Affiliation (Current)	2024: 京都大学, 農学研究科, 准教授
Affiliation (based on the past Project Information) *help	2024: 京都大学, (連合)農学研究科(研究院), 准教授 2015 – 2024: 京都大学, 農学研究科, 准教授 2013 – 2015: 京都大学, (連合)農学研究科(研究院), 准教授 2013: 京都大学, 大学院・農学研究科, 准教授 2013: 京都大学, 大学院農学研究科, 准教授 … More 2012: 京都大学, (連合)農学研究科(研究院), 助教 2012: 京都大学, 大学院・農学研究科, 助教 2010 – 2011: 京都大学, 農学研究科, 助教 Less
Review Section/Research Field	Principal Investigator Transformative Research Areas, Section (III) / Medium-sized Section 37:Biomolecular chemistry and related fields / Bioorganic chemistry / Basic Section 37020:Chemistry and chemical methodology of biomolecules-related / Basic Section 38040:Bioorganic chemistry-related / Biomolecular chemistry / ケミカルバイオロジー Except Principal Investigator Bioproduction chemistry/Bioorganic chemistry / Broad Section H / Medium-sized Section 37:Biomolecular chemistry and related fields / Science and Engineering / Bioorganic chemistry
Keywords	Principal Investigator 神経変性疾患 / アミロイドβ / アプタマー / アルツハイマー病 / 国際共同研究 / エクソソーム / NMR / オリゴマー / ドラッグデリバリーシステム / 核酸医薬 … More / 計算科学 / 有機合成化学 / 標的探索 / 漢方生薬 / 核酸アプタマー / 凝集 / 分子進化 / 高速AFM / アミロイド / RNA結合タンパク質 / 女性活躍 / アウトリーチ / 若手支援 / 研究推進 / 診断薬 / ペプチド合成 / 超硫黄 / αシヌクレイン / 大腸がん / 片利共生 / プロバイオティクス / ヒューミマイシン / コリバクチン / 天然物化学 / 抗菌活性 / 腸内細菌 / 代謝 / 生薬 / 天然物バンク / 有機化学 / 質量分析 / 脳神経疾患 / siRNA / 磁性ビーズ / ビオチン化 / シグナル伝達 / MS/MS / トリテルペノイド / 構造決定 / カギカズラ / トリテルペン / チョウトウコウ / 単離構造決定 / インスリン受容体 / ビタミンC / 酸化ストレス / ラジカル / 光親和性標識 / スーパーオキシドラジカル / 細胞質SOD / アルキン / アジド / フイスゲン反応 / プロドラッグ / 白金 / Huisgen反応 / ジアミノピペリン酸 / RNA / アミロイド β … More Except Principal Investigator 有機化学 / アルツハイマー病 / 抗体 / アミロイドβ / 毒性オリゴマー / 脳神経疾患 / アプリシアトキシン / プロテインキナーゼC / アルツハイマー / オリゴマー / フラボノイド / 毒性ターン / 凝集 / 酸化ストレス / 過酸化脂質ラジカル / エネルギー代謝 / 超硫黄カテネーション / 超硫黄分子 / ２量体 / ジスルフィド架橋 / がん細胞増殖抑制 / ヒト免疫不全ウイルス / マクラマイシン / CH/π相互作用 / 酵素 / 薬理学 / 癌 / シグナル伝達 / HIV / アロタケタール / 機械学習 / ホルボールエステル / 発がんプロモーター / プロテインキナーゼＣ / 神経細胞毒性 / ノックインマウス / 核酸アプタマー / 診断 / 脳脊髄液 / ラジカル / 硫黄 / 固体NMR / アミロイド / 光アフィニティーラベリング / 毒性コンホマー / 抗ターン抗体 / シナプス毒性 / クルクミン / タキシフォリン / βアミロイド / Aβ42 / カテコール / 凝集抑制 Less

Exploring supersulfide that mediates energy metabolism and redox signaling
- Principal Investigator
  
  赤池孝章
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section H
- Research Institution
  Tohoku University
神経変性疾患における超硫黄化アミロイドの役割に関する国際共同研究Principal Investigator
- Principal Investigator
  
  村上一馬
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Fund for the Promotion of Joint International Research (International Collaborative Research)
- Review Section
  
  Medium-sized Section 37:Biomolecular chemistry and related fields
- Research Institution
  Kyoto University
Supramolecular behavior and dynamic capture of metastable amyloid aggregatesArea Organizer
- Area Organizer
  
  村上一馬
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
Supramolecular behavior and dynamic capture of meta-aggregatesPrincipal Investigator
- Principal Investigator
  
  村上一馬
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Kyoto University
[Amyloid and protein] Comprehensive search and validation of meta-aggregates by molecular evolutionary methodPrincipal Investigator
- Principal Investigator
  
  村上一馬
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Kyoto University
Structural chemistry of intracellular recognition by nucleic acid aptamers and brain barrier permeation strategies for the treatment of neurodegenerative diseasesPrincipal Investigator
- Principal Investigator
  
  村上一馬
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  Kyoto University
Development of highly sensitive detection method for supersulfide amyloid using nucleic acid probe and exosomePrincipal Investigator
- Principal Investigator
  
  村上一馬
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Kyoto University
Bioorganic studies on the genotoxicity of colibactin produced from human microbiome in colorectal cancerPrincipal Investigator
- Principal Investigator
  
  村上一馬
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38040:Bioorganic chemistry-related
- Research Institution
  Kyoto University
International research project on nucleic acid aptamers and their exosome-based application to therapeutics for synucleinopathyPrincipal Investigator
- Principal Investigator
  
  Murakami Kazuma
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 37:Biomolecular chemistry and related fields
- Research Institution
  Kyoto University
Very early diagnosis of Alzheimer's disease by the toxic oligomer specific antibody of amyloid beta
- Principal Investigator
  
  入江一浩
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 37:Biomolecular chemistry and related fields
- Research Institution
  Kyoto University
Unified comprehension of chemical communication by natural PKC ligands and development of new medicinal seeds
- Principal Investigator
  
  Irie Kazuhiro
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  Kyoto University
Structural organic chemistry in inhibitory mechanism of amyloid beta oligomerizationPrincipal Investigator
- Principal Investigator
  
  Murakami Kazuma
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Kyoto University
Search for novel target molecules of intracellular amyloid betaPrincipal Investigator
- Principal Investigator
  
  Murakami Kazuma
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biomolecular chemistry
- Research Institution
  Kyoto University
Novel Preventive Strategy for Alzheimer's Disease Based on the Toxic Conformation Theory of Amyloid beta
- Principal Investigator
  
  Irie Kazuhiro
- Project Period (FY)
  2014 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Kyoto University
Identification of amyloid beta aggregation inhibitors in a traditional herbal medicine Uncaria rhynchophylla and their inhibitory mechanismPrincipal Investigator
- Principal Investigator
  
  MURAKAMI Kazuma
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Kyoto University
33S solid-state NMR analysis of methionine radical inducing cytotoxicity of amyloid-beta protein
- Principal Investigator
  
  MASUDA YUICHI
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Tohoku University
Development of RNA aptamer against toxic Aβ oligomerPrincipal Investigator
- Principal Investigator
  
  MURAKAMI Kazuma
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  ケミカルバイオロジー
- Research Institution
  Kyoto University
Development of medicinal seeds for Alzheimer's disease based on the structural analysis of toxic oligomers of amyloid beta
- Principal Investigator
  
  IRIE Kazuhiro
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Kyoto University

[Book] New Tide of Natural Product Chemistry (Chapter 15: High-Throughput Searches for Natural Products as Aggregation Modulators of Amyloidogenic Proteins)2023
- Author(s)
  Kazuma Murakami
- Total Pages
  356
- Publisher
  Springer Nature
- ISBN
  9789819917136
- Data Source
  KAKENHI-PROJECT-20K05849
[Book] Diet and Nutrition in Dementia and Cognitive Decline: Potential role of vitamin C in the prevention of Alzheimer’s disease2014
- Author(s)
  Murakami, K. et al.
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-25850080
[Book] タンパク質の異常凝集とその防御・修復機構に関する研究会報告（VI）2013
- Author(s)
  村上一馬ら
- Total Pages
  5
- Publisher
  京都大学原子炉実験所
- Data Source
  KAKENHI-PROJECT-25850080
[Book] 遺伝子医学MOOK21号「最新ペプチド合成技術とその創薬研究への応用」：固体NMRおよびESRによるアミロイド β の立体構造解析と毒性ターン構造特異抗体の開発2012
- Author(s)
  村上　一馬
- Total Pages
  6
- Publisher
  メディカル　ドゥ
- Data Source
  KAKENHI-PROJECT-21248015
[Book] 固体NMR およびESR によるアミロイド β の立体構造解析と毒性ターン構造特異抗体の開発, 遺伝子医学MOOK21 号「最新ペプチド合成技術とその創薬研究への応用」2012
- Author(s)
  村上一馬, 増田裕一, *入江一浩
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PROJECT-21248015
[Book] 遺伝子医学MOOK第21巻「最新ペプチド合成技術とその創薬研究への応用」(木曽良明編)2012
- Author(s)
  村上一馬,増田裕一,入江一浩
- Data Source
  KAKENHI-PROJECT-24780108
[Book] タンパク質の異常凝集とその防御・修復機構に関する研究会報告(IV)2011
- Author(s)
  村上一馬
- Total Pages
  5
- Publisher
  京都大学原子炉実験所
- Data Source
  KAKENHI-PROJECT-22603006
[Book] 遺伝子医学MOOK21号「最新ペプチド合成技術とその創薬研究への応用」2011
- Author(s)
  村上一馬, 他2名
- Publisher
  株式会社メディカルドゥ
- Data Source
  KAKENHI-PROJECT-21248015
[Book] タンパク質の異常凝集とその防御・修復機構に関する研究会報告(III)2010
- Author(s)
  村上一馬
- Total Pages
  5
- Publisher
  アミロイドβ異常凝集における「折れ曲がり」の役割
- Data Source
  KAKENHI-PROJECT-22603006
[Journal Article] 腸内細菌生産天然物による創薬研究の新展開2023
- Author(s)
  村上一馬
- Journal Title
  
  アグリバイオ
  
  Volume: －
- Data Source
  KAKENHI-PROJECT-20K05849
[Journal Article] Detection of Dietary Chalcone and Flavonoid Metabolites in Mice Using UPLC-MS/MS and Their Modulatory Effects on Amyloid β Aggregation2023
- Author(s)
  Taniwa Kota, Murakami Kazuma, Sakaguchi Yoshiki, Izuo Naotaka, Hanaki Mizuho, Sampa Nobuaki, Kume Toshiaki, Shimizu Takahiko, Irie Kazuhiro
- Journal Title
  
  Journal of Agricultural and Food Chemistry
  
  Volume: 71 Issue: 39 Pages: 14289-14299
- DOI
  10.1021/acs.jafc.3c02598
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26221202
[Journal Article] 統計解析を駆使した生物活性物質の探索法－アミロイド蛋白質の凝集を阻害するファンクショナルフードを例として－2023
- Author(s)
  村上一馬
- Journal Title
  
  Functional Food Research
  
  Volume: －
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05849
[Journal Article] 神経疾患に対する核酸医薬：アプタマー医薬2023
- Author(s)
  村上一馬
- Journal Title
  
  脳神経内科
  
  Volume: －
- Data Source
  KAKENHI-PROJECT-20KK0126
[Journal Article] Aptamers targeting amyloidogenic proteins and their emerging role in neurodegenerative diseases2022
- Author(s)
  Murakami Kazuma、Izuo Naotaka、Bitan Gal
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 298 Issue: 1 Pages: 101478-101478
- DOI
  10.1016/j.jbc.2021.101478
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16006, KAKENHI-PROJECT-20KK0126, KAKENHI-PROJECT-22H04922
[Journal Article] Lysine-targeting inhibition of amyloid β oligomerization by a green perilla-derived metastable chalcone in vitro and in vivo.2022
- Author(s)
  Murakami, K., Sakaguchi, Y., Taniwa, K., Izuo, N., Hanaki, M., Kawase, T., Hirose, K., Nagao, C., Mizoguchi, K., Shimizu, T., Irie, K.
- Journal Title
  
  RSC Chem. Biol.
  
  Volume: 3 Issue: 12 Pages: 1380-1396
- DOI
  10.1039/d2cb00194b
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19607, KAKENHI-PROJECT-20H03583, KAKENHI-PROJECT-20K16006, KAKENHI-PROJECT-26221202
[Journal Article] Interactions of amyloid coaggregates with biomolecules and its relevance to neurodegeneration2022
- Author(s)
  Murakami K, Ono K.
- Journal Title
  
  The FASEB Journal
  
  Volume: 36 Issue: 9
- DOI
  10.1096/fj.202200235r
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07965, KAKENHI-PROJECT-22K07514, KAKENHI-PROJECT-20KK0126
[Journal Article] Searching for natural products that delay nucleation phase and promote elongation phase of amyloid beta42 toward Alzheimer's disease therapeutics2021
- Author(s)
  Murakami Kazuma, Horii Shiori, Hanaki Mizuho, Irie Kazuhiro
- Journal Title
  
  ACS Chemical Neuroscience
  
  Volume: 12 Issue: 18 Pages: 3467-3476
- DOI
  10.1021/acschemneuro.1c00489
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26221202
[Journal Article] Development of a Novel Alzheimer's Disease Model Based on the Theory of the Toxic-conformer of Amyloid β2021
- Author(s)
  泉尾直孝、清水孝彦、村上一馬、入江一浩
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 141 Issue: 6 Pages: 843-849
- DOI
  10.1248/yakushi.20-00251-5
- NAID
  130008046322
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2021-06-01
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26221202, KAKENHI-PROJECT-20H03583, KAKENHI-PROJECT-20K16006
[Journal Article] アミロイドタンパク質を認識する核酸アプタマー2021
- Author(s)
  村上一馬、入江一浩
- Journal Title
  
  化学と生物
  
  Volume: 59 Pages: 216-218
- Data Source
  KAKENHI-PROJECT-26221202
[Journal Article] An RNA aptamer with potent affinity for a toxic dimer of amyloid β42 has potential utility for histochemical studies of Alzheimer's disease2020
- Author(s)
  Murakami Kazuma, Obata Yayoi, Sekikawa Asa, Ueda Haruka, Awano Tatsuya, Takabe Keiji, Takahiko Shimizu, Irie Kazuhiro
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 295 Issue: 15 Pages: 4870-4880
- DOI
  10.1074/jbc.ra119.010955
- Description
  in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26221202, KAKENHI-PROJECT-16H06194, KAKENHI-PROJECT-20H03583
[Journal Article] Synthetic biology based construction of biological activity-related library focused on fungal decalin-containing diterpenoid pyrones2020
- Author(s)
  1.Tsukada K, Shinki S, Kaneko A, Murakami K, Irie K, Murai M, Miyoshi H, Dan S, Kawaji K, Hayashi H, Kodama E, Hori A, Salim E, Kuraishi T, Hirata N, Kanda Y, Asai T.
- Journal Title
  
  Nature Communications
  
  Volume: 11 Issue: 1 Pages: 1830-1830
- DOI
  10.1038/s41467-020-15664-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16349, KAKENHI-PROJECT-17H04107, KAKENHI-PROJECT-20K20463, KAKENHI-PROJECT-16H06194, KAKENHI-PUBLICLY-19H04642, KAKENHI-PROJECT-19H03701, KAKENHI-PROJECT-17H05055, KAKENHI-PROJECT-18K19388, KAKENHI-PROJECT-19K17921
[Journal Article] Synthesis and physicochemical properties of 20-mer peptide nucleic acid conjugates with testosterone 17β-carboxylic acid2020
- Author(s)
  Yagita Ryotaro、Murakami Kazuma、Ikeda Hisafumi、Irie Kazuhiro
- Journal Title
  
  Tetrahedron Letters
  
  Volume: 61 Issue: 17 Pages: 151781-151781
- DOI
  10.1016/j.tetlet.2020.151781
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H06194
[Journal Article] Detection of amyloid β oligomers with RNA aptamers in AppNL-G-F/NL-G-F Mice: a model of Arctic Alzheimer’s disease2020
- Author(s)
  Obata Yayoi、*Murakami Kazuma、Kawase Taiji、Hirose Kenji、Izuo Naotaka、Shimizu Takahiko、*Irie Kazuhiro
- Journal Title
  
  ACS Omega
  
  Volume: 5 Issue: 34 Pages: 21531-21537
- DOI
  10.1021/acsomega.0c02134
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06194, KAKENHI-PROJECT-20H03583, KAKENHI-PROJECT-26221202
[Journal Article] Synthetic and biochemical studies on the effect of persulfidation on disulfide dimer models of amyloid β42 at position 35 in Alzheimer's etiology2020
- Author(s)
  Murakami Kazuma, Kato Haruka, Hanaki Mizuho, Monobe Yoko, Akagi Ken-ichi, Kawase Taiji, Hirose Kenji, Irie Kazuhiro
- Journal Title
  
  RSC Advances
  
  Volume: 10 Issue: 33 Pages: 19506-19512
- DOI
  10.1039/d0ra03429k
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26221202, KAKENHI-PROJECT-16H06194
[Journal Article] Evaluation of Toxic Amyloid β42 Oligomers in Rat Primary Cerebral Cortex Cells and Human iPS-derived Neurons Treated with 10-Me-Aplog-1, a New PKC Activator2020
- Author(s)
  Murakami Kazuma、Yoshimura Mayuko、Nakagawa Shota、Kume Toshiaki、Kondo Takayuki、Inoue Haruhisa、Irie Kazuhiro
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 4 Pages: 1179-1179
- DOI
  10.3390/ijms21041179
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07119, KAKENHI-PLANNED-17H06405, KAKENHI-PROJECT-17K16121
[Journal Article] Synthetic and biophysical studies on the toxic conformer in amyloid β with the E22Δ mutation in Alzheimer pathology2020
- Author(s)
  Murakami K, Yamaguchi T, Izuo N, Kume T, Hara H, Irie K.
- Journal Title
  
  ACS Chem Neurosci.
  
  Volume: 11 Issue: 19 Pages: 3017-3024
- DOI
  10.1021/acschemneuro.0c00331
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07119, KAKENHI-PROJECT-16H06194
[Journal Article] Three structural features of functional food components and herbal medicine with amyloid β42 anti-aggregation properties2019
- Author(s)
  Murakami Kazuma, Irie Kazuhiro
- Journal Title
  
  Molecules
  
  Volume: 24 Issue: 11 Pages: 2125-2125
- DOI
  10.3390/molecules24112125
- NAID
  120006644072
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26221202, KAKENHI-PROJECT-16H06194
[Journal Article] An App knock-in mouse inducing the formation of a toxic conformer of Aβ as a model for evaluating only oligomer-induced cognitive decline in Alzheimer's disease2019
- Author(s)
  Izuo Naotaka, Murakami Kazuma, Fujihara Yoshitaka, Maeda Masahiro, Saito Takashi, Saido C. Takaomi, Irie Kazuhiro, Shimizu Takahiko
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 515 Issue: 3 Pages: 462-467
- DOI
  10.1016/j.bbrc.2019.05.131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26221202
[Journal Article] Synthesis and biochemical characterization of quasi-stable trimer models of full-length amyloid β40 with a toxic conformation2019
- Author(s)
  Irie Yumi、Hanaki Mizuho、Murakami Kazuma、Imamoto Tsuneo、Furuta Takumi、Kawabata Takeo、Kawase Taiji、Hirose Kenji、Monobe Yoko、Akagi Ken-ichi、Yanagita Ryo C.、Irie Kazuhiro
- Journal Title
  
  Chemical Communications
  
  Volume: 55 Issue: 2 Pages: 182-185
- DOI
  10.1039/c8cc08618d
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26221202, KAKENHI-PROJECT-18H02554
[Journal Article] Amyloid β toxic conformer has dynamic localization in the human inferior parietal cortex in absence of amyloid plaques2018
- Author(s)
  Kageyama Yusuke、Saito Atsushi、Pletnikova Olga、Rudow Gay L.、Irie Yumi、An Yang、Murakami Kazuma、Irie Kazuhiro、Resnick Susan M.、Fowler David R.、Martin Lee J.、Troncoso Juan C.
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 16895-16895
- DOI
  10.1038/s41598-018-35004-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221202
[Journal Article] アミロイドβ「毒性コンホマー」を標的にしたアルツハイマー病の治療・診断法の開発2018
- Author(s)
  泉尾直孝、清水孝彦、村上一馬、入江一浩
- Journal Title
  
  医薬品医療機器レギュラトリーサイエンス
  
  Volume: 49 Pages: 312-318
- Data Source
  KAKENHI-PROJECT-26221202
[Journal Article] Role of the carboxy groups of triterpenoids in their inhibition of the nucleation of amyloid β42 required for forming toxic oligomers2018
- Author(s)
  Murakami Kazuma、Yoshioka Takuya、Horii Shiori、Hanaki Mizuho、Midorikawa Satohiro、Taniwaki Shinji、Gunji Hiroki、Akagi Ken-ichi、Kawase Taiji、Hirose Kenji、Irie Kazuhiro
- Journal Title
  
  Chemical Communications
  
  Volume: 54 Issue: 49 Pages: 6272-6275
- DOI
  10.1039/c8cc03230k
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26221202, KAKENHI-PROJECT-16H06194
[Journal Article] Mechanistic analyses of the suppression of amyloid β42 aggregation by apomorphine2018
- Author(s)
  Mizuho Hanaki, Kazuma Murakami, Sumie Katayama, Ken-ichi Akagi, Kazuhiro Irie
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 26 Issue: 8 Pages: 1538-1546
- DOI
  10.1016/j.bmc.2018.01.028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26221202
[Journal Article] 食品・生薬成分によるアミロイドβ42の凝集抑制機構の系統的解析2017
- Author(s)
  村上一馬，入江一浩
- Journal Title
  
  Dementia Japan
  
  Volume: 31 Pages: 351-360
- Data Source
  KAKENHI-PROJECT-16H06194
[Journal Article] 食品・生薬成分によるアミロイドβ42の凝集抑制機構の系統的解析2017
- Author(s)
  村上一馬、入江一浩
- Journal Title
  
  日本認知症学会誌
  
  Volume: 31 Pages: 351-360
- Data Source
  KAKENHI-PROJECT-26221202
[Journal Article] A toxic conformer of Aβ42 with a turn at 22-23 is a novel therapeutic target for Alzheimer’s disease2017
- Author(s)
  Naotaka Izuo, Chihiro Kasahara, Kazuma Murakami, Toshiaki Kume, Masahiro Maeda, Kazuhiro Irie, Koutaro Yokote, Takahiko Shimizu
- Journal Title
  
  Sci. Rep.
  
  Volume: 7 Issue: 1 Pages: 11811-11811
- DOI
  10.1038/s41598-017-11671-6
- NAID
  120006368174
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26221202, KAKENHI-PROJECT-17H01558, KAKENHI-PROJECT-15K07965, KAKENHI-PROJECT-16J05570, KAKENHI-PROJECT-15K19279
[Journal Article] Synthetic models of quasi-stable amyloid β40 oligomers with significant neurotoxicity2017
- Author(s)
  Yumi Irie, Kazuma Murakami, Mizuho Hanaki, Yusuke Hanaki, Takashi Suzuki, Yoko Monobe, Tomoyo Takai, Ken-ichi Akagi, Taiji Kawase, Kenji Hirose, Kazuhiro Irie
- Journal Title
  
  ACS Chem. Neurosci.
  
  Volume: 8 Issue: 4 Pages: 807-816
- DOI
  10.1021/acschemneuro.6b00390
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26221202
[Journal Article] Semisynthesis and structure-activity studies of Uncarinic acid C Isolated from Uncaria rhynchophylla as a specific inhibitor of the nucleation phase in amyloid β42 aggregation2016
- Author(s)
  Takuya Yoshioka, Kazuma Murakami, Kyohei Ido, Mizuho Hanaki, Kanoko Yamaguchi, Satohiro Midorikawa, Shinji Taniwaki, Hiroki Gunji, Kazuhiro Irie
- Journal Title
  
  J. Nat. Prod.
  
  Volume: 79 Issue: 10 Pages: 2521-2529
- DOI
  10.1021/acs.jnatprod.6b00392
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26221202
[Journal Article] Monoclonal antibody with conformational specificity for a toxic conformer of amyloid β42 and its application toward the Alzheimer's disease diagnosis2016
- Author(s)
  Kazuma Murakami, Maki Tokuda, Takashi Suzuki, Yumi Irie, Mizuho Hanaki, Naotaka Izuo, Yoko Monobe, Ken-ichi Akagi, Ryotaro Ishii, Harutsugu Tatebe, Takahiko Tokuda, Masahiro Maeda, Toshiaki Kume, Takahiko Shimizu, Kazuhiro Irie
- Journal Title
  
  Sci. Rep.
  
  Volume: 6 Issue: 1 Pages: 29038-29038
- DOI
  10.1038/srep29038
- NAID
  120005774689
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221202, KAKENHI-PROJECT-26293165, KAKENHI-PROJECT-26462283, KAKENHI-PROJECT-16K14254, KAKENHI-PROJECT-15K07965, KAKENHI-PROJECT-15K09322, KAKENHI-PROJECT-15K19279, KAKENHI-PROJECT-16J05570
[Journal Article] Structural insights into mechanisms for inhibiting amyloid β42 aggregation by non-catechol-type flavonoids2016
- Author(s)
  Mizuho Hanaki, Kazuma Murakami, Ken-ichi Akagi, Kazuhiro Irie*
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 24 Issue: 2 Pages: 304-313
- DOI
  10.1016/j.bmc.2015.12.021
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26221202
[Journal Article] Synthesis and characterization of the amyloid β40 dimer model with a linker at position 30 adjacent to the intermolecular β-sheet region2015
- Author(s)
  Kazuma Murakami, Takashi Suzuki, Mizuho Hanaki, Yoko Monobe, Ken-ichi Akagi, Kazuhiro Irie*
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 466 Issue: 3 Pages: 463-467
- DOI
  10.1016/j.bbrc.2015.09.051
- NAID
  120005679859
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26221202
[Journal Article] アルツハイマー病様神経毒性におけるアミロイドβコンホマーの役割2015
- Author(s)
  泉尾直孝*、村上一馬、久米利明、前田雅弘、入江一浩、清水孝彦
- Journal Title
  
  基礎老化研究
  
  Volume: 39 Pages: 29-34
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26221202
[Journal Article] Conformation-specific antibodies to target amyloid beta oligomers and their application to immunotherapy for Alzheimer's disease2014
- Author(s)
  Kazuma Murakami
- Journal Title
  
  Biosci. Biotechnol. Biochem.
  
  Volume: 78 Issue: 8 Pages: 1293-1305
- DOI
  10.1080/09168451.2014.940275
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26221202
[Journal Article] Structure–Activity Relationship for (+)-Taxifolin Isolated from Silymarin as an Inhibitor of Amyloid β Aggregation2013
- Author(s)
  Sato, M., Murakami, K., (他5名), Irie, K
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 77 Issue: 5 Pages: 1100-1103
- DOI
  10.1271/bbb.120925
- NAID
  10031177604
- ISSN
  0916-8451, 1347-6947
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248015
[Journal Article] Site-specific inhibitory mechanism for amyloid-β42 aggregation by catechol-type flavonoids targeting the Lys-residues2013
- Author(s)
  Sato, M., Murakami, K., Ikubo, H., Uno, M., Nakagawa, Y., Katayama, S., Akagi, K.-i., Masuda, Y., Takegoshi, K., *Irie, K
- Journal Title
  
  J.Biol.Chem
  
  Volume: 288 Issue: 32 Pages: 23212-23224
- DOI
  10.1074/jbc.m113.464222
- NAID
  120005477416
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248015, KAKENHI-PROJECT-24780108
[Journal Article] Intracellular accumulation of toxic turn amyloid-β is associated with endoplasmic reticulum stress in Alzheimer's disease2013
- Author(s)
  Soejima, N., Ohyagi, Y., (他6名), Murakami, K., Irie, K., (他5名)
- Journal Title
  
  Curr. Alzheimer Res
  
  Volume: 10 Pages: 11-20
- URL
  http://www.eurekaselect.com/106388/article
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248015
[Journal Article] A drug screening platform for Alzheimer's disease with intracellular Aβ oligomers using patient-specific iPSCs2013
- Author(s)
  Kondo, T., (他24名), Murakami, K., Irie, K., Klein, W. L., Mori, H., Asada, T., Takahashi, R., Iwata, N., Yamanaka, S., Inoue, H
- Journal Title
  
  Cell Stem Cell
  
  Volume: 12 Issue: 4 Pages: 487-496
- DOI
  10.1016/j.stem.2013.01.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21248015, KAKENHI-PLANNED-22129006, KAKENHI-ORGANIZER-23111001, KAKENHI-PLANNED-23111002, KAKENHI-PROJECT-23249049, KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-23592093, KAKENHI-PROJECT-24220009, KAKENHI-PROJECT-24500408, KAKENHI-PROJECT-24590040, KAKENHI-PROJECT-24700367, KAKENHI-PROJECT-24790260, KAKENHI-PROJECT-24790276, KAKENHI-PUBLICLY-25123709, KAKENHI-PROJECT-25290018, KAKENHI-PROJECT-25460341, KAKENHI-PUBLICLY-23110535, KAKENHI-PUBLICLY-23123510
[Journal Article] Non-toxic conformer of Aβ42 may suppress Aβ42-induced toxicity in rat primary neurons : implications for the novel therapeutic strategy of Alzheimer's disease2013
- Author(s)
  Izuo, N., Murakami, K., (他3名), Shimizu, T., Akaike, A., Irie, K., Kume, T
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 438 Issue: 1 Pages: 1-5
- DOI
  10.1016/j.bbrc.2013.05.106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248015, KAKENHI-PROJECT-24390139, KAKENHI-PROJECT-24590111, KAKENHI-PROJECT-25460095, KAKENHI-PROJECT-25670036
[Journal Article] アミロイド β の毒性ターン構造を認識する抗体の開発2012
- Author(s)
  村上　一馬
- Journal Title
  
  神経内科
  
  Volume: 77 Pages: 179-184
- Data Source
  KAKENHI-PROJECT-21248015
[Journal Article] アミロイド β の「毒性コンホマー」形成とGlu22位における遺伝性変異2012
- Author(s)
  村上　一馬
- Journal Title
  
  Dementia Japan
  
  Volume: 26 Pages: 311-318
- Data Source
  KAKENHI-PROJECT-21248015
[Journal Article] Lack of the Consensus Sequence Necessary for Tryptophan Prenylation in the ComX Pheromone Precursor2012
- Author(s)
  F. Tsuji, A. Ishihara, A. Nakagawa, M. Okada, S. Kitamura, K. Kanamaru, Y. Masuda, K. Murakami, K. Irie, and Y. Sakagami.
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 76 Issue: 8 Pages: 1492-1496
- DOI
  10.1271/bbb.120206
- NAID
  10031065914
- ISSN
  0916-8451, 1347-6947
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23658098, KAKENHI-PROJECT-24688011, KAKENHI-PROJECT-24780108
[Journal Article] Early accumulation of intracellular fibrillar oligomers and late congophilic amyloid angiopathy in mice expressing the Osaka intra-Aβ APP mutation2012
- Author(s)
  Kulic, L., (他10名), Shimizu, T., Murakami, K., Irie, K., (他4名)
- Journal Title
  
  Transl. Psychiatry
  
  Volume: 2 Issue: 11 Pages: e183-e183
- DOI
  10.1038/tp.2012.109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248015
[Journal Article] Cytoplasmic superoxide radicals as contributing factors to intracellular Aβ oligomerization in Alzheimer's disease2012
- Author(s)
  Kazuma Murakami, 他1名
- Journal Title
  
  Communicative & Integrative Biology
  
  Volume: 5(3)(印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22603006
[Journal Article] Toxicity in rat primary neuron through the cellular oxidative stress induced by the turn formation 22 and 23 of AB422012
- Author(s)
  Naotaka Izuo
- Journal Title
  
  ACS Chemycal Neuroscience
  
  Volume: 3(9) Issue: 9 Pages: 647-681
- DOI
  10.1021/cn300033k
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J04068, KAKENHI-PROJECT-21248015, KAKENHI-PROJECT-23790083, KAKENHI-PROJECT-24390139, KAKENHI-PROJECT-24590111
[Journal Article] Stimulation of the Amyloidogenic Pathway by Cytoplasmic Superoxide Radicals in an Alzheimer's Disease Mouse Model2012
- Author(s)
  Murakami, K., Murata, N., Noda, Y., Irie, K., Shirasawa, T., Shimizu, T
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 76 Issue: 6 Pages: 1098-1103
- DOI
  10.1271/bbb.110934
- NAID
  10030817824
- ISSN
  0916-8451, 1347-6947
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248015, KAKENHI-PROJECT-22603006
[Journal Article] Vitamin C restores behavioral deficits and Aβ oligomerization without affecting plaque formation in a mouse model of Alzheimer's disease2011
- Author(s)
  Kazuma Murakami, 他6名
- Journal Title
  
  J.Alzheimers Dis.
  
  Volume: 26 Issue: 1 Pages: 7-18
- DOI
  10.3233/jad-2011-101971
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248015
[Journal Article] SOD1 (cupper/zinc superoxide dismutase) deficiency drives amyloid β protein oligomerization and memory loss in mouse model of Alzheimer's disease2011
- Author(s)
  Murakami, K., (他8名), Irie, K., Shirasawa, T., Shimizu, T
- Journal Title
  
  J. Biol. Chem
  
  Volume: 286 Issue: 52 Pages: 44557-44568
- DOI
  10.1074/jbc.m111.279208
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248015, KAKENHI-PROJECT-22300118, KAKENHI-PROJECT-22603006
[Journal Article] Insulin receptor mutation results in insulin resistance and hyperinsulinemia but does not exacerbate Alzheimer's-like phenotypes in mice2011
- Author(s)
  Kazuma Murakami, 他6名
- Journal Title
  
  Biophys.Biochem.Res.Commun.
  
  Volume: 409 Issue: 1 Pages: 34-39
- DOI
  10.1016/j.bbrc.2011.04.101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248015
[Journal Article] Insulin receptor mutation results in insulin resistance and hyperinsulinemia but does not exacerbate Alzheimer's-like phenotypes in mice2011
- Author(s)
  Kazuma Murakami
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22603006
[Journal Article] Vitamin C restores behavioral deficits and Aβ oligomerization without affecting plaque formation in a mouse model of Alzheimer's disease2011
- Author(s)
  Kazuma Murakami
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22603006
[Journal Article] Formation of the 42-mer amyloid β radical and the therapeutic role of superoxide dismutase in Alzheimer's disease2011
- Author(s)
  Kazuma Murakami
- Journal Title
  
  Journal of Amino Acids
  
  Volume: 2011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22603006
[Journal Article] Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 232010
- Author(s)
  Murakami, K., (他8名), Shimizu, T., Irie, K
- Journal Title
  
  ACS Chem. Neurosci
  
  Volume: 1 Issue: 11 Pages: 747-756
- DOI
  10.1021/cn100072e
- NAID
  130004504903
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248015
[Journal Article] Silymarin Attenuated the Amyloid .BETA. Plaque Burden and Improved Behavioral Abnormalities in an Alzheimer's Disease Mouse Model2010
- Author(s)
  Murata, N., Murakami, K., Ozawa, Y., Kinoshita, N., Irie, K., Shirasawa, T., Shimizu T
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 74 Issue: 11 Pages: 2299-2306
- DOI
  10.1271/bbb.100524
- NAID
  10027561730
- ISSN
  0916-8451, 1347-6947
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248015
[Journal Article] The turn formation at positions 22 and 23 in the 42-mer amyloid β peptide : The emerging role in the pathogenesis of Alzheimer's disease2010
- Author(s)
  Kazuma Murakami
- Journal Title
  
  Geriatr. Gerontol. Int. 10(suppl.1)(in press)
- NAID
  10027273706
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248015
[Journal Article] E22Δ mutation in amyloid β-protein promotes β-sheet transformation, radical production, and synaptotoxicity, but not neurotoxicity2010
- Author(s)
  Suzuki, T., Murakami, K., (他7名), Irie, K
- Journal Title
  
  Int. J. Alzheimers Dis
  
  Volume: 431320 Issue: 1
- DOI
  10.4061/2011/431320
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248015
[Journal Article] The turn formation at positions 22 and 23 in the 42-mer amyloid beta peptide : the emerging role in the pathogenesis of Alzheimer's disease2010
- Author(s)
  Murakami, K., Masuda, Y., Shirasawa, T., Shimizu, T., Irie, K
- Journal Title
  
  Geriatr. Gerontol. Int
  
  Volume: 10 Issue: s1
- DOI
  10.1111/j.1447-0594.2010.00598.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248015
[Journal Article] Monoclonal antibody against the toxic turn of the 42-residue amyloid β peptide at positions 22 and 232010
- Author(s)
  Kazuma Murakami
- Journal Title
  
  ACS Chem.Neurosci.
  
  Volume: 1 Pages: 747-756
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248015
[Patent] RNAアプタマー2023
- Inventor(s)
  村上一馬
- Industrial Property Rights Holder
  村上一馬
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-023603
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-20KK0126
[Patent] アミロイドβの22位及び23位のターン構造を極めて特異的に認識する抗体（学内整理番号：4718）2015
- Inventor(s)
  入江一浩，村上一馬，清水孝彦，泉尾直孝，清藤勉
- Industrial Property Rights Holder
  入江一浩，村上一馬，清水孝彦，泉尾直孝，清藤勉
- Industrial Property Rights Type
  特許
- Filing Date
  2015-12-14
- Overseas
- Data Source
  KAKENHI-PROJECT-26221202
[Patent] アミロイドβの22位及び23位のターン構造を極めて特異的に認識する抗体2014
- Inventor(s)
  入江一浩，村上一馬，清水孝彦，泉尾直孝，清藤　勉
- Industrial Property Rights Holder
  入江一浩，村上一馬，清水孝彦，泉尾直孝，清藤　勉
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-251898
- Filing Date
  2014-12-12
- Data Source
  KAKENHI-PROJECT-26221202
[Patent] アミロイド β のターン構造を認識する抗体2011
- Inventor(s)
  入江一浩, 村上一馬, 増田裕一, 清水孝彦,白澤卓二, 清藤勉
- Industrial Property Rights Holder
  入江一浩, 村上一馬, 増田裕一, 清水孝彦,白澤卓二, 清藤勉
- Industrial Property Rights Type
  特許
- Filing Date
  2011-04-21
- Overseas
- Data Source
  KAKENHI-PROJECT-21248015
[Patent] Antibody recognizing tumstructure in amyloid β2010
- Inventor(s)
  Kazuhiro Irie, Kazuma Murakami, Yuichi Masuda, Takahiko Shimizu, Takuji Shirasawa, Tsutomu Seito
- Industrial Property Rights Holder
  Kazuhiro Irie, Kazuma Murakami, Yuichi Masuda, Takahiko Shimizu, Takuji Shirasawa, Tsutomu Seito
- Industrial Property Rights Type
  特許
- Filing Date
  2010-10-18
- Acquisition Date
  2014-04-29
- Overseas
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] アミロイドタンパク質を認識する核酸アプタマー2023
- Author(s)
  村上一馬
- Organizer
  日本薬学会北陸支部特別講演会
- Invited
- Data Source
  KAKENHI-PROJECT-20KK0126
[Presentation] アミロイド凝集を阻害する天然物の論理的探索法2023
- Author(s)
  村上一馬
- Organizer
  第19回ファンクショナルフード学会学術集会（先端シンポジウム）
- Invited
- Data Source
  KAKENHI-PROJECT-20K05849
[Presentation] アミロイド蛋白質を認識する核酸アプタマー2023
- Author(s)
  村上一馬
- Organizer
  第14回タンパク質の異常凝集とその防御・修復機構に関する研究会
- Invited
- Data Source
  KAKENHI-PROJECT-20KK0126
[Presentation] Development of RNA aptamers that recognizes amyloid key structures2022
- Author(s)
  Kazuma Murakami
- Organizer
  Special seminar in Neurology at UCLA
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20KK0126
[Presentation] アミロイドタンパク質を認識する核酸アプタマーの創製と応用2022
- Author(s)
  村上一馬
- Organizer
  日本農芸化学会2022年度大会
- Invited
- Data Source
  KAKENHI-PROJECT-20KK0126
[Presentation] Synthesis of conformation-restricted analogues of amyloid persulfide toward their application to nucleic acid medicine2022
- Author(s)
  Kazuma Murakami, Masayoshi Mochizuki, Taku Yoshiya, Naotaka Izuo
- Organizer
  Redox Week in Sendai 2002 (4th International Conference on Persulfide and Sulfur Metabolism in Biology and Medicine)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H05564
[Presentation] 超硫黄化アミロイドに特異的な核酸プローブとエクソソームを用いた高感度検出法の開発2022
- Author(s)
  村上一馬
- Organizer
  学術変革領域研究（A）新興硫黄生物学が拓く生命原理変革（硫黄生物学）第２回領域会議
- Data Source
  KAKENHI-PUBLICLY-22H05564
[Presentation] アンチセンス治療を指向した長鎖ペプチド核酸の合成研究2021
- Author(s)
  村上一馬、八木田凌太郎、池田壽文、入江一浩
- Organizer
  日本農芸化学会2021年度大会（仙台、オンライン）
- Data Source
  KAKENHI-PROJECT-16H06194
[Presentation] Suppression of toxic amyloid β42 oligomers in rat primary cerebral cortex cells and human iPS-derived neurons treated with 10-Me-Aplog-1, a new PKC activator2021
- Author(s)
  Murakami Kazuma、Yoshimura Mayuko、Nakagawa Shota、Kume Toshiaki、Kondo Takayuki、Inoue Haruhisa、Irie Kazuhiro
- Organizer
  2021 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2021) virtual
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] 青ジソに含まれるアミロイドβ42 の凝集阻害物質・DDC の代謝物の合成と活性2021
- Author(s)
  谷輪厚太、村上一馬、坂口嘉紀、入江一浩
- Organizer
  日本農芸化学会2021年度大会（仙台、オンライン）
- Data Source
  KAKENHI-PROJECT-16H06194
[Presentation] RNA aptamers recognize amyloid oligomers with in AppNL-G-F/NL-G-F mice as a model of Arctic Alzheimer disease2020
- Author(s)
  Murakami Kazuma, Obata Yayoi, Kawase Taiji, Hirose Kenji, Izuo Naotaka, Shimizu Takahiko, Irie Kazuhiro
- Organizer
  Alzheimer's Association International Conference 2020 (Virtual)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06194
[Presentation] アミロイドβの凝集阻害機構に基づいた天然物ライブラリーの分類（ポスター発表演題選出）2020
- Author(s)
  村上一馬、堀井詩織、定光達斗、花木瑞穂、郡司祐樹、入江一浩
- Organizer
  日本農芸化学会2020年度大会（福岡）＊講演要旨の公表のみ
- Data Source
  KAKENHI-PROJECT-16H06194
[Presentation] Aβ42のパースルフィド化に関する化学研究2020
- Author(s)
  村上一馬、加藤春花、花木瑞穂、物部容子、赤木謙一、川瀬泰司、廣瀬賢治、入江一浩
- Organizer
  第39回日本認知症学会学術集会（名古屋、ハイブリッド）
- Data Source
  KAKENHI-PROJECT-16H06194
[Presentation] アミロイドβ42の毒性オリゴマーを認識するRNAアプタマーの開発2020
- Author(s)
  村上一馬、小畑弥生、関川あさ、上田遥、川瀬泰司、廣瀬賢治、泉尾直孝、清水孝彦、入江一浩
- Organizer
  第62回天然有機化合物討論会（口頭、オンライン）
- Data Source
  KAKENHI-PROJECT-16H06194
[Presentation] アミロイドβの凝集を抑制する食品・生薬成分の作用機構2019
- Author(s)
  入江一浩、村上一馬
- Organizer
  2019年度日本農芸化学会大会（東京農大、東京）
- Invited
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アミロイドβ42のプロトフィブリルを認識するRNAアプタマー（学会奨励賞候補演題（基礎））2019
- Author(s)
  村上一馬、小畑弥生、関川あさ、上田遥、泉尾直孝、粟野達也、高部圭司、清水孝彦、入江一浩
- Organizer
  第38回日本認知症学会学術集会（東京）
- Data Source
  KAKENHI-PROJECT-16H06194
[Presentation] 準安定なアミロイドβの毒性オリゴマーモデルの合成と機能解析2019
- Author(s)
  入江由美、村上一馬、花木瑞穂、花木祐輔、鈴木天志、今本恒雄、古田　巧、川端猛夫、川瀬泰司、廣瀬賢治、柳田　亮、入江一浩
- Organizer
  第61回天然有機化合物討論会（広島国際会議場、広島市）
- Data Source
  KAKENHI-PROJECT-19H00921
[Presentation] Strategy for development of RNA aptamers that target the toxic oligomers of Aβ422019
- Author(s)
  Murakami Kazuma, Obata Yayoi, Sekikawa Asa, Ueda Haruka, Izuo Naotaka, Awano Tatsuya, Takabe Keiji, Shimizu Takahiko, Irie Kazuhiro
- Organizer
  Alzheimer's Association International Conference 2019 (Los Angeles, USA)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06194
[Presentation] アミロイドβ40の3量体モデルの合成と神経細胞毒性2019
- Author(s)
  入江由美、花木瑞穂、村上一馬、今本恒雄、古田　巧、川端猛夫、川瀬泰司、廣瀬賢治、柳田　亮、入江一浩
- Organizer
  第38回日本認知症学会学術集会（京王プラザホテル、東京）
- Data Source
  KAKENHI-PROJECT-19H00921
[Presentation] アミロイドβ42の毒性オリゴマーに対する核酸アプタマーの開発研究と脳組織染色への応用2019
- Author(s)
  村上一馬、小畑弥生、関川あさ、上田遥、泉尾直孝、粟野達也、高部圭司、清水孝彦、入江一浩
- Organizer
  2019年度日本農芸化学会大会（東京農大、東京）優秀発表
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] 分子内ジスルフィド結合によるアミロイドβ 42の毒性配座固定アナログの合成と生化学的機能解析2019
- Author(s)
  松島由佳、村上一馬、入江一浩
- Organizer
  第9回認知症研究を知る若手研究者の集まり(ホテルヘリテイジ・リゾート、熊谷市）
- Data Source
  KAKENHI-PROJECT-19H00921
[Presentation] 分子内ジスルフィド結合形成によるアミロイドβ42の毒性配座モデルの合成と機能解析2019
- Author(s)
  松島由佳、村上一馬、花木瑞穂、粟野達也、高部圭司、柳田亮、入江一浩
- Organizer
  2019年度日本農芸化学会大会（東京農大、東京）
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] Strategy for development of RNA aptamers targeting the toxic oligomers of Aβ422019
- Author(s)
  Kazuma Murakami
- Organizer
  UCLA Integrative Center for Neural Repair Seminar (Mini-symposium: "Oligomers in Alzheimer's disease: Elucidation of disease mechanisms and development of therapeutics")
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06194
[Presentation] Evaluation system of amyloid beta precursor protein processing in rat primary cortical neurons treated with PKC activators2019
- Author(s)
  Yoshimura Mayuko、Murakami Kazuma、Kume Toshiaki、Irie Kazuhiro
- Organizer
  新学術領域研究「化学コミュニケーションのフロンティア」第1回国際シンポジウム（一橋大学一橋講堂、東京）
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06405
[Presentation] アミロイドβの凝集を抑える天然物の３つの特徴2019
- Author(s)
  村上一馬、入江一浩
- Organizer
  第2回日本食品科学工学会関西支部大会「脳機能に影響を与える食品成分」シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-16H06194
[Presentation] アミロイドβの毒性オリゴマー形成阻害能を有する生薬化合物のカルボキシ基の役割2018
- Author(s)
  堀井詩織，村上一馬，花木瑞穂，粟野達也，高部圭司，川瀬泰司，廣瀬賢治，入江一浩
- Organizer
  2019年度日本農芸化学会大会
- Data Source
  KAKENHI-PROJECT-16H06194
[Presentation] 分子内ジスルフィド結合形成によるアミロイドβの毒性コンホメーションの制御2018
- Author(s)
  松島由佳、村上一馬、花木瑞穂、粟野達也、高部圭司、柳田亮、入江一浩
- Organizer
  第37回日本認知症学会学術集会（ロイトン札幌・札幌市教育文化会館、札幌市）
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] 青ジソに含まれるアミロイドβ42の凝集阻害物質の作用機構とマウスにおける生体内代謝2018
- Author(s)
  坂口嘉紀，村上一馬，花木瑞穂，泉尾直孝，小澤裕介，粟野達也，高部圭司，川瀬泰司，廣瀬賢治，三羽伸明，久米利明，清水孝彦，入江一浩
- Organizer
  2018年度日本農芸化学会大会
- Data Source
  KAKENHI-PROJECT-16H06194
[Presentation] 青ジソに含まれるアミロイドβ42の凝集阻害物質の作用機構とマウスにおける生体内代謝2018
- Author(s)
  坂口嘉紀、村上一馬、花木瑞穂、泉尾直孝、小澤祐介、粟野達也、高部圭司、川瀬泰司、廣瀬賢治、三羽伸明、久米利明、清水孝彦、入江一浩
- Organizer
  2018年度日本農芸化学会大会（大会トピックス賞）（名城大学、名古屋市）
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アミロイドβ42の毒性2量体モデルから形成されるプロトフィブリルを標的としたRNAアプタマーの開発2018
- Author(s)
  小畑弥生、村上一馬、関川あさ、入江一浩
- Organizer
  2018年度日本農芸化学会大会（名城大学、名古屋市）
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アミロイドβ42の2量体モデル由来の毒性オリゴマーに対するRNAアプタマー2018
- Author(s)
  小畑弥生、村上一馬、関川あさ、粟野達也、髙部圭司、入江一浩
- Organizer
  日本核酸医薬学会第4回年会（九州大学医学部百年講堂、福岡市）
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] 天然物によるアミロイドβの毒性オリゴマー形成阻害機構2018
- Author(s)
  村上一馬，吉岡卓也，堀井詩織，花木瑞穂，緑川諭弘，谷脇慎治，郡司祐樹，赤木謙一，川瀬泰司，廣瀬賢治，入江一浩
- Organizer
  第37回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-16H06194
[Presentation] アポモルフィンによるアミロイドβ42凝集抑制機構の解析2018
- Author(s)
  花木瑞穂、村上一馬、片山寿美枝、赤木謙一、入江一浩
- Organizer
  2018年度日本農芸化学会大会（名城大学、名古屋市）
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] RNA aptamers targeting the toxic oligomers of Aβ42 and their application to immunohistochemistry2018
- Author(s)
  Murakami Kazuma、Obata Yayoi、Sekikawa Asa、Ueda Haruka、Izuo Naotaka、Awano Tatsuya、Takabe Keiji、Shimizu Takahiko、Irie Kazuhiro
- Organizer
  The 45th International Symposium on Nucleic Acids Chemistry (Kyoto University Clock Tower Centennial Hall, Kyoto, Japan)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] 漢方由来ウンカリン酸 C によるアミロイド β42 核形成阻害メカニズム2017
- Author(s)
  吉岡卓也、村上一馬、花木瑞穂、緑川諭弘、谷脇慎治、郡司祐樹、川瀬泰司、廣瀬賢治、入江一浩
- Organizer
  2017年度日本農芸化学会大会
- Place of Presentation
  京都女子大学（京都府京都市）
- Year and Date
  2017-03-20
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アミロイドβの毒性配座理論と抗体創製2017
- Author(s)
  村上一馬、入江一浩
- Organizer
  認知症研究を知る若手研究者の集まり2017（湯の宿木もれび、大津市）
- Invited
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アミロイドβ40の毒性オリゴマーモデル2017
- Author(s)
  入江由美、村上一馬、花木瑞穂、花木祐輔、鈴木天志、物部容子、高井朋代、赤木謙一、川瀬泰司、廣瀬賢治、入江一浩
- Organizer
  2017年度日本農芸化学会大会
- Place of Presentation
  京都女子大学（京都府京都市）
- Year and Date
  2017-03-20
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] オリゴマー仮説の視点からバイオマーカーを考える：アミロイドβの毒性配座理論2017
- Author(s)
  村上一馬、入江一浩
- Organizer
  第36回日本認知症学会学術集会（ANAクラウンプラザホテル金沢、金沢市）
- Invited
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] Inhibitory mechanism of amyloid β aggregation by traditional herbal medicine and functional food components2017
- Author(s)
  Kazuma Murakami and Kazuhiro Irie
- Organizer
  Zhejiang University-Kyoto University Joint Workshop
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06194
[Presentation] 漢方由来ウンカリン酸によるアミロイドβ42核形成阻害メカニズム2017
- Author(s)
  吉岡卓也，村上一馬，花木瑞穂，緑川諭弘，谷脇慎治，郡司祐樹，川瀬泰司，廣瀬賢治，入江一浩
- Organizer
  2017年度日本農芸化学会大会
- Place of Presentation
  京都女子大学（京都市）
- Data Source
  KAKENHI-PROJECT-16H06194
[Presentation] アミロイドβ「毒性コンホマー」を標的にしたアルツハイマー病の治療・診断法の開発2017
- Author(s)
  泉尾直孝、久米利明、村上一馬、徳田隆彦、前田雅弘、入江一浩、清水孝彦
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2017-03-25
- Invited
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] 生薬チョウトウコウに含まれるアミロイドβオリゴマー形成阻害物質の同定と作用機構2017
- Author(s)
  村上一馬、吉岡卓也、井戸恭平、花木瑞穂、山口加乃子、緑川諭弘、谷脇慎治、郡司祐樹、赤木謙一、川瀬泰司、廣瀬賢治、入江一浩
- Organizer
  第59回天然有機化合物討論会（札幌市民ホール、札幌市）
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] 神経細胞毒性を有する準安定なアミロイドβの2量体モデルの合成とイオンモビリティー質量分析法による構造解析2017
- Author(s)
  入江一浩、入江由美、村上一馬、花木瑞穂、花木祐輔、川瀬泰司、廣瀬賢治、徳田隆彦、前田雅弘
- Organizer
  第35回メディシナルケミストリーシンポジウム（豊田講堂、名古屋市）
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アミロイドβの毒性配座抗体とその診断応用2016
- Author(s)
  村上一馬
- Organizer
  天然有機化合物と創薬R&D
- Place of Presentation
  筑波大学筑波キャンパス
- Invited
- Data Source
  KAKENHI-PROJECT-15K12744
[Presentation] アミロイドβのラジカル化：アルツハイマー病態におけるSOD1の役割2016
- Author(s)
  村上一馬、清水孝彦、入江一浩
- Organizer
  第11回レドックス・ライフイノベーションシンポジウム
- Place of Presentation
  お茶の水女子大学（東京都文京区）
- Year and Date
  2016-03-17
- Invited
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] 天然ポリフェノールによるAβ42凝集阻害機構の解明とアルツハイマー病予防の可能性2016
- Author(s)
  村上一馬、入江一浩
- Organizer
  第35回日本認知症学会学術集会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Year and Date
  2016-12-03
- Invited
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] ウンカリン酸によるアミロイドβ凝集核形成の選択的阻害2016
- Author(s)
  吉岡卓也、村上一馬、井戸恭平、花木瑞穂、山口加乃子、緑川諭弘、谷脇慎治、郡司祐樹、入江一浩
- Organizer
  第35回日本認知症学会学術集会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Year and Date
  2016-12-02
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] 天然ポリフェノールによるAβ42凝集阻害機構の解明とアルツハイマー病予防の可能性2016
- Author(s)
  村上一馬，入江一浩
- Organizer
  第35回日本認知症学会学術集会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Invited
- Data Source
  KAKENHI-PROJECT-16H06194
[Presentation] Characterization of the monoclonal antibody (24B3) highly recognizing the toxic turn of amyloid β42 and its application to diagnosis for Alzheimer’s disease2016
- Author(s)
  Kazuma Murakami, Mizuho Hanaki, Maki Tokuda, Ken-ichi kagi, Ryotaro Ishii, Harutsugu Tatebe, Takahiko Tokuda, Masahiro Maeda, Naotaka Izuo, Takahiko Shimizu, Kazuhiro Irie
- Organizer
  The 8th Takeda Science Foundation Symposium on PharmaSciences “Biomolecule-based Medicinal Science: Featuring Mid-Size Drugs”
- Place of Presentation
  Takeda Pharmaceutical Company, Ltd. (Suita, Japan)
- Year and Date
  2016-01-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] Passive immunization with the toxic conformer of Aβ ameliorated behavioral abnormalities in Alzheimer’s-like model without affecting senile plaque deposition2016
- Author(s)
  泉尾直孝、村上一馬、久米利明、入江一浩、横手幸太郎、清水孝彦
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-10
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] チョウトウコウに含まれるウンカリン酸Ｃおよびその誘導体のアミロイドβ凝集阻害活性2016
- Author(s)
  吉岡卓也、村上一馬、花木瑞穂、緑川諭弘、谷脇慎治、郡司裕樹、入江一浩
- Organizer
  2016年度日本農芸化学会大会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2016-03-28
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アミロイドβの毒性コンホマーにきわめて特異的な抗体の開発とアルツハイマー病診断への応用2016
- Author(s)
  村上一馬、徳田真樹、鈴木天志、入江由美、花木瑞穂、柳田亮、物部容子、赤木謙一、石井亮太郎、建部陽嗣、徳田隆彦、前田雅弘、久米利明、泉尾直孝、清水孝彦、入江一浩
- Organizer
  2016年度日本農芸化学会大会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2016-03-28
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] Aβ42の22-23位におけるターン構造はAβ42誘発神経毒性を調節する2016
- Author(s)
  泉尾直孝、久米利明、村上一馬、前田雅弘、入江一浩、清水孝彦
- Organizer
  日本基礎老化学会大会
- Place of Presentation
  伊勢原市民文化会館（神奈川県伊勢原市）
- Year and Date
  2016-05-27
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アミロイドβ40の2量体モデルの合成と神経細胞毒性2016
- Author(s)
  入江由美、村上一馬、鈴木天志、花木瑞穂、花木祐輔、物部容子、高井朋代、赤木謙一、入江一浩
- Organizer
  第35回日本認知症学会学術集会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Year and Date
  2016-12-02
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] Identification of the “toxic conformer” of amyloid β and its pathogenic contribution of Alzheimer's disease2016
- Author(s)
  Naotaka Izuo, Kazuma Murakami, Toshiaki Kume, Masahiro Maeda, Kazuhiro Irie, Takahiko Shimizu
- Organizer
  2016 Spring International Conference of the Korean Society for Gerontology
- Place of Presentation
  Convention Hall (Daegu, Korea)
- Year and Date
  2016-06-16
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アミロイドβの毒性コンホマーを極めて特異的に認識する抗体の開発とAD診断への応用2015
- Author(s)
  村上一馬、花木瑞穂、赤木謙一、石井亮太郎、徳田隆彦、前田雅弘、泉尾直孝、清水孝彦、入江一浩
- Organizer
  第34回日本認知症学会学術集会
- Place of Presentation
  リンクステーションホール青森（青森県青森市）
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アミロイドβペプチドの毒性配座理論に基づいた構造特異抗体の開発と診断薬への応用2015
- Author(s)
  村上一馬、入江一浩
- Organizer
  第47回若手ペプチド夏の勉強会
- Place of Presentation
  信州塩尻・天然温泉アスティかたおか（長野県塩尻市）
- Year and Date
  2015-08-11
- Invited
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アミロイドβ42ダイマーの合成と活性評価2015
- Author(s)
  徳田真樹、村上一馬、鈴木天志、花木瑞穂、岩崎真実、久米利明、入江一浩
- Organizer
  2015年度日本農芸化学会大会
- Place of Presentation
  岡山大学津島キャンパス（岡山市）
- Year and Date
  2015-03-27
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] Structural insight into the inhibitory mechanism of amyloid β42 aggregation by non-catechol-type flavonoids2015
- Author(s)
  Mizuho Hanaki, Kazuma Murakami, Ken-ichi Akagi, Kazuhiro Irie
- Organizer
  2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015)
- Place of Presentation
  Hilton Hawaiian Villege (Honolulu, USA)
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] Aβ 毒性コンホマーの選択的除去は老人斑に影響せずアルツハイマー病症状を改善する2015
- Author(s)
  泉尾直孝、村上一馬、前田雅弘、久米利明、横手幸太郎、入江一浩、清水孝彦
- Organizer
  第34回日本認知症学会学術集会
- Place of Presentation
  リンクステーションホール青森（青森県青森市）
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アミロイドβの「毒性コンホマー」を標的とした受動免疫療法はアルツハイマー病モデルの神経症状を改善する2015
- Author(s)
  泉尾直孝、村上一馬、徳田隆彦、久米利明、赤池昭紀、白澤卓二、横手幸太郎、入江一浩、清水孝彦
- Organizer
  日本基礎老化学会大会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2015-06-13
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アミロイドβの毒性配座理論に基づいた構造特異抗体の開発と診断薬への応用2015
- Author(s)
  村上一馬、入江一浩
- Organizer
  第8回たんぱく質の異常凝集とその防御・修復機構に関する研究会
- Place of Presentation
  京都大学原子炉実験所（大阪府熊取町）
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] SOFAST-HMQC NMR を用いた非カテコール型フラボノイドによるアミロイドβの凝集抑制機構の解析2015
- Author(s)
  花木瑞穂、村上一馬、赤木謙一、入江一浩
- Organizer
  2015年度日本農芸化学会中部・関西支部合同大会
- Place of Presentation
  富山県立大学（富山県射水市）
- Year and Date
  2015-09-20
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] Characterization of monoclonal antibodies against the toxic turn of amyloid β42 and their application to diagnosis for Alzheimer’s disease2015
- Author(s)
  Kazuma Murakami, Mizuho Sato-Hanaki, L. M. Moro, G. Giaccone, F. Tagliavini, Ken-ichi Akagi, Ryotaro Ishii, Takahiko Tokuda, Masahiko Maeda, Naotaka Izuo, Takahiko Shimzu, Kazuhiro Irie
- Organizer
  2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015)
- Place of Presentation
  Hilton Hawaiian Villege (Honolulu, USA)
- Year and Date
  2015-12-15
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] Aβ毒性コンホマーの選択的除去は老人班蓄積を阻害せずにアルツハイマー病モデルマウスの行動異常を改善する2015
- Author(s)
  泉尾直孝、村上一馬、前田雅弘、久米利明、横手幸太郎、入江一浩、清水孝彦
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-04
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] 非カテコール型フラボノイドによるアミロイドβの凝集抑制機構2015
- Author(s)
  花木瑞穂、村上一馬、赤木謙一、入江一浩
- Organizer
  第57回天然有機化合物討論会
- Place of Presentation
  神奈川県民ホール（神奈川県横浜市）
- Year and Date
  2015-09-09
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] Pathophysiological activities of the “toxic conformer” and the “non-toxic conformer” of amyloid β-induced neurotoxicity2015
- Author(s)
  泉尾直孝、久米利明、村上一馬、入江一浩、泉安彦、赤池昭紀、横手幸太郎、清水孝彦
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋国際会議場（名古屋市）
- Year and Date
  2015-03-19
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アミロイドβを標的としたアルツハイマー病の新しい治療戦略2014
- Author(s)
  村上一馬
- Organizer
  日本農芸化学会中部支部　第172回例会（若手シンポジウム）「化学の視点から拓く天然物・生命科学研究」
- Place of Presentation
  信州大学農学部（長野県南箕輪村）
- Year and Date
  2014-11-22
- Invited
- Data Source
  KAKENHI-PROJECT-25850080
[Presentation] Synthesis and biological activities of the Abeta40 dimer with toxic conformation2014
- Author(s)
  Kazuhiro Irie, Kazuma Murakami, Takashi Suzuki, Mizuho Sato, Mami Iwasaki, Toshiaki Kume
- Organizer
  Alzheimer’s Association International Conference 2014
- Place of Presentation
  Bella Center A/S (Copenhagen, Denmark)
- Year and Date
  2014-07-14
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] Inhibitors for Aβ42 aggregation in a traditional herbal medicine Uncaria rhynchophylla2014
- Author(s)
  Kazuma Murakami, Kyohei Ido, Mizuho Sato, Kanoko Yamaguchi, and Kazuhiro Irie
- Organizer
  Alzheimer's Association International Conference 2014
- Place of Presentation
  Bella Center A/S (Copenhagen, Denmark)
- Year and Date
  2014-07-14
- Data Source
  KAKENHI-PROJECT-25850080
[Presentation] Vitamin C and silymarin restores Aβ oligomerization and behavioral abnormality in Alzheimer's pathology2013
- Author(s)
  Murakami, K., Murata, N., Ozawa, Y., Irie, K., Shirasawa, T., Shimizu, T
- Organizer
  Alzheimer's Association International Conference (AAIC) 2013
- Place of Presentation
  Boston, USA
- Year and Date
  2013-07-15
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] 細胞質酸化ストレスによるアミロイドβオリゴマー形成能および記憶異常の促進2012
- Author(s)
  村上一馬
- Organizer
  日本農芸化学会2012年度大会
- Place of Presentation
  京都女子大学
- Year and Date
  2012-03-24
- Data Source
  KAKENHI-PROJECT-22603006
[Presentation] Specific Inhibitory Mechanism of Aggregation of 42-mer Amyloid-βPeptide by Flavonoids2012
- Author(s)
  Sato, M., Murakami, K., Ikubo, H., Uno, M., Nakagawa, Y., Katayama, S., Akagi, K., Masuda, Y., Takegoshi, K., Irie, K.
- Organizer
  IKCOC-12
- Place of Presentation
  Kyoto(ポスター発表, Poster Number PA-140)
- Year and Date
  2012-11-13
- Data Source
  KAKENHI-PROJECT-24780108
[Presentation] ポリフェノールによるアミロイドβ の凝集阻害機構2012
- Author(s)
  入江一浩, 村上一馬, 佐藤瑞穂, 井久保遥子, 宇野真弓, 中川優, 片山寿美枝, 赤木謙一
- Organizer
  第31回日本認知症学会学術集会
- Place of Presentation
  つくば
- Year and Date
  2012-10-28
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] カテコール系フラボノイド類によるアミロイドβの凝集抑制機構2012
- Author(s)
  村上一馬,佐藤瑞穂,井久保遥子,宇野真弓,中川優,片山寿美枝,赤木謙一,増田裕一,竹腰清乃理,入江一浩
- Organizer
  第54回天然有機化合物討論会
- Place of Presentation
  東京(口頭発表,講演番号17,査読あり)
- Year and Date
  2012-09-19
- Data Source
  KAKENHI-PROJECT-24780108
[Presentation] カテコール系フラボノイド類によるアミロイドβの凝集抑制機構2012
- Author(s)
  村上一馬，佐藤瑞穂，井久保遥子，宇野真弓，中川優，片山寿美枝，赤木謙一，増田裕一，竹腰清乃理，入江一浩
- Organizer
  第54回天然有機化合物討論会
- Place of Presentation
  東京農業大学世田谷キャンパス
- Data Source
  KAKENHI-PROJECT-24780108
[Presentation] Specific Inhibitory Mechanism of Aggregation of 42-mer Amyloid-beta Peptide by Flavonoids2012
- Author(s)
  Mizuho Sato, Kazuma Murakami, Haruko Ikubo, Mayumi Uno, Yu Nakagawa, Sumie Katayama, Ken-ichi Akagi, Yuichi Masuda, Kiyonori Takegoshi, and Kazuhiro Irie
- Organizer
  The 12th International Kyoto Conference on New Aspects of Organic Chemistry
- Place of Presentation
  Rihga Royal Hotel Kyoto
- Data Source
  KAKENHI-PROJECT-24780108
[Presentation] カテコール系フラボノイド類によるアミロイドβ の凝集抑制機構2012
- Author(s)
  村上一馬, 佐藤瑞穂, 井久保遥子, 宇野真弓, 中川優, 片山寿美枝, 赤木謙一, 増田裕一, 竹腰清乃理, 入江一浩
- Organizer
  第54回天然有機化合物討論会
- Place of Presentation
  東京
- Year and Date
  2012-09-19
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] Monoclonal antibody against a toxic conformer of Aβ42 with a turn at E22-D232012
- Author(s)
  Irie, K., Murakami, K., Horikoshi-Sakuraba, Y., Kinoshikta, N., Shirasawa, T., Shimizu, T., Tokuda, T
- Organizer
  Alzheimer's Association International Conference (AAIC) 2012
- Place of Presentation
  Vancouver, British Columbia, Canada
- Year and Date
  2012-07-15
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] 抗酸化ストレスに着目したアルツハイマー病予防の可能性2011
- Author(s)
  村上一馬
- Organizer
  京都大学原子炉実験所専門研究会「タンパク質の異常凝集とフォールディング病」
- Place of Presentation
  京都大学原子炉実験所(大阪)(招待講演)
- Year and Date
  2011-11-10
- Data Source
  KAKENHI-PROJECT-22603006
[Presentation] E22Δ mutation promotes the formation of toxic conformer in Alzheimer's peptide, Aβ422011
- Author(s)
  Murakami, K., Suzuki, T., Izuo, N., Kume, T., Akaike, A., Nagata, T., Nishizaki, T., Tomiyama, T., Takuma, H., Mori, H., Irie, K
- Organizer
  27th International Symposium on the Chemistry of Natural Products, 7th International Conference on Biodiversity
- Place of Presentation
  Brisbane, Australia
- Year and Date
  2011-07-11
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] 大阪変異によるアミロイドβの毒性コンホマー形成能の増大2011
- Author(s)
  村上一馬
- Organizer
  第30回日本認知症学会学術集会
- Place of Presentation
  タワーホール船堀(東京)
- Year and Date
  2011-11-11
- Data Source
  KAKENHI-PROJECT-22603006
[Presentation] E22Δ mutation promotes the formation of toxic conformer in Alzheimer's peptide, Aβ422011
- Author(s)
  Kazuma Murakami
- Organizer
  27th International Symposium on the Chemistry of Natural Products, 7th International Conference on Biodiversity
- Place of Presentation
  Convention & Exibition Center (Brisbane, Australia)
- Year and Date
  2011-07-11
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] アミロイドβ の毒性コンホマーを標的とした立体構造特異的抗体2010
- Author(s)
  村上一馬, 堀越(櫻庭)優子, 村田央, 野田義博, 増田裕一, 木下憲明, 初田裕幸, 村山繁雄, 白澤卓二, 清水孝彦, 入江一浩
- Organizer
  2010年度日本農芸化学会大会
- Place of Presentation
  東京
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] アルツハイマー病と機能性食品因子(Alzheimer's disease and functional foods)2010
- Author(s)
  Kazuma Murakami
- Organizer
  Invited Lecturer in Gwangju University
- Place of Presentation
  Gwangju大学(Gwangju,韓国)
- Year and Date
  2010-10-13
- Data Source
  KAKENHI-PROJECT-22603006
[Presentation] Structural analysis of toxic conformer of 42-mer amyloid β peptide using ESR spectrometry2010
- Author(s)
  Kazuma Murakami
- Organizer
  7^<th> Asia-Pacific EPR/ESR Symposium
- Place of Presentation
  Convention Center(Jeju,韓国)
- Year and Date
  2010-10-12
- Data Source
  KAKENHI-PROJECT-22603006
[Presentation] アミロイドβ (Aβ42) の毒性コンホマー特異的抗体の作製2010
- Author(s)
  村上一馬, 堀越(櫻庭)優子, 村田央, 野田義博, 増田裕一, 木下憲明, 初田裕幸, 村山繁雄, 白澤卓二, 清水孝彦, 入江一浩
- Organizer
  第52回天然有機化合物討論会
- Place of Presentation
  静岡
- Year and Date
  2010-09-30
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] アミロイドβの毒性コンホマーを標的とした立体構造特異的抗体[トピックス賞]2010
- Author(s)
  村上一馬
- Organizer
  2010年度日本農芸化学大会
- Place of Presentation
  東京大学駒場キャンパス(東京都)
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] Structural analysis of toxic conformer of 42-mer amyloid β peptide using ESR spectrometry2010
- Author(s)
  Murakami, K. and Irie, K
- Organizer
  Asia-Pacific EPR/ESR symposium
- Place of Presentation
  Jeju, Republic of Korea
- Year and Date
  2010-10-12
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] アミロイドβ異常凝集における「折れ曲がり」の役割2010
- Author(s)
  村上一馬
- Organizer
  京都大学原子炉実験所専門研究会「タンパク質の異常凝集とフォールディング病」
- Place of Presentation
  京都大学原子炉実験所(大阪)
- Year and Date
  2010-11-12
- Data Source
  KAKENHI-PROJECT-22603006
[Presentation] SilymarinによるADモデルマウスの行動異常ならびにアミロイドβオリゴマー形成の予防効果2010
- Author(s)
  村上一馬
- Organizer
  2010年度日本農芸化学会関西支部大会
- Place of Presentation
  近畿大学(奈良)
- Year and Date
  2010-10-02
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] アミロイドβ(Aβ42)の毒性コンホマー特異的抗体の作製(第52回天然有機化合物討論会奨励賞受賞)2010
- Author(s)
  村上一馬
- Organizer
  第52回天然有機化合物討論会
- Place of Presentation
  グランシップ(静岡)
- Year and Date
  2010-09-30
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] Monoclonal antibody against the toxic turn structure of the 42-mer amyloid β peptide2010
- Author(s)
  Kazuma Murakami
- Organizer
  2010 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010)
- Place of Presentation
  Convention Center (Hawaii, USA)
- Year and Date
  2010-12-18
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] アミロイドβの毒性ターン構造特異的抗体2010
- Author(s)
  村上一馬
- Organizer
  第29回日本認知症学会学術集会
- Place of Presentation
  ウインク愛知(名古屋)
- Year and Date
  2010-11-05
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] Development of a monoclonal antibody against the toxic conformer of the 42-mer amyloid β protein2009
- Author(s)
  Kazuma Murakami
- Organizer
  39th Annual Meeting of Society for Neuroscience
- Place of Presentation
  Chicago, USA
- Year and Date
  2009-10-18
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] 酸化ストレスに着目したアミロイドβペプチドの神経細胞毒性発現機構
- Author(s)
  村上一馬
- Organizer
  農芸化学奨励賞受賞講演
- Place of Presentation
  電力ホール（仙台）
- Data Source
  KAKENHI-PROJECT-22603006
[Presentation] アミロイドβの毒性オリゴマー認識薬開発への挑戦
- Author(s)
  村上一馬
- Organizer
  新学術領域研究　天然物ケミカルバイオロジー　地区ミニシンポジウム「化学と生物学の壁と打開策：次世代天然物ケミカルバイオロジー研究の開拓へ」
- Place of Presentation
  理化学研究所鈴木梅太郎記念ホール（和光市）
- Invited
- Data Source
  KAKENHI-PROJECT-25850080
[Presentation] 酸化ストレスに着目したアミロイドβペプチドの神経細胞毒性発現機構
- Author(s)
  村上一馬
- Organizer
  農芸化学会関西支部例会（第483回講演会）
- Place of Presentation
  京都大学楽友会館（京都市）
- Invited
- Data Source
  KAKENHI-PROJECT-25850080
[Presentation] ポリフェノールによるアミロイド β の凝集阻害機構
- Author(s)
  村上一馬ら
- Organizer
  第3回生理化学ユニットシンポジウム
- Place of Presentation
  京都大学楽友会館（京都市）
- Invited
- Data Source
  KAKENHI-PROJECT-25850080
[Presentation] Vitamin C and silymarin restores Aβ oligomerization and behavioral abnormality in Alzheimer’s pathology
- Author(s)
  Murakami, K. et al.
- Organizer
  Alzheimer’s Association International Conference 2013
- Place of Presentation
  Boston Convention Center（Boston MA, USA）
- Data Source
  KAKENHI-PROJECT-25850080
[Presentation] カテコール系フラボノイド類によるアミロイドβの凝集抑制機構
- Author(s)
  村上　一馬
- Organizer
  第54回天然有機化合物討論会
- Place of Presentation
  東京農業大学（東京都世田谷区）
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] 伝統生薬チョウトウコウに含まれるアミロイドβ凝集抑制物質
- Author(s)
  村上一馬ら
- Organizer
  2014年度日本農芸化学会大会
- Place of Presentation
  明治大学生田キャンパス（川崎市）
- Data Source
  KAKENHI-PROJECT-25850080
[Presentation] ポリフェノールによるアミロイドβ42の凝集抑制機構
- Author(s)
  村上一馬ら
- Organizer
  第6回タンパク質の異常凝集とその防御・修復機構に関する研究会
- Place of Presentation
  京都大学原子炉実験所（大阪府熊取町）
- Invited
- Data Source
  KAKENHI-PROJECT-25850080
[Presentation] アミロイドβオリゴマーの形成と空間記憶異常における細胞質SODの役割
- Author(s)
  村上　一馬
- Organizer
  第31回日本認知症学会学術集会
- Place of Presentation
  つくば国際会議場（つくば市）
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] CuZn-SOD loss accelerates the formation of amyloid beta oligomer and memory impairment in Tg2576 mice
- Author(s)
  Kazuma Murakami
- Organizer
  Alzheimer's Association International Conference (AAIC) 2012
- Place of Presentation
  Vancouver Convention Center (Canada)
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] ポリフェノールによるアミロイドβ42の凝集抑制機構
- Author(s)
  村上一馬ら
- Organizer
  第6回タンパク質の異常凝集とその防御・修復機構に関する研究会
- Place of Presentation
  京都大学原子炉実験所（熊取町）
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] CuZn-SOD loss accelerates the formation of amyloid β oligomer and memory impairment in Tg2576 mice
- Author(s)
  Kazuma Murakami
- Organizer
  Alzheimer's Association International Conference
- Place of Presentation
  Vancouver Convention Center (Canada)
- Data Source
  KAKENHI-PROJECT-22603006
[Presentation] アミロイド β ペプチドの毒性ターン構造の同定とその構造特異抗体の開発
- Author(s)
  村上一馬
- Organizer
  第47回天然物化学談話会
- Place of Presentation
  阿蘇プラザホテル（熊本）
- Data Source
  KAKENHI-PROJECT-22603006
[Presentation] ビタミンCにおるアルツハイマー病態緩和
- Author(s)
  村上一馬
- Organizer
  2013年度日本農芸化学会大会
- Place of Presentation
  東北大学川内北キャンパス（仙台）
- Data Source
  KAKENHI-PROJECT-22603006

1. IRIE Kazuhiro (00168535)

# of Collaborated Projects: 4 results

# of Collaborated Products: 82 results
2. SHIMIZU Takahiko (40301791)

# of Collaborated Projects: 3 results

# of Collaborated Products: 33 results
3. TAKEGOSHI Kiyonori (10206964)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
4. KUME Toshiaki (10303843)

# of Collaborated Projects: 2 results

# of Collaborated Products: 18 results
5. 徳田隆彦 (80242692)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
6. 喜田昭子 (70273430)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 泉尾直孝 (50722261)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
8. 水口賢司 (50450896)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. MASUDA YUICHI (90617755)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
10. IZUMI Shunsuke (90203116)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 柳田亮 (10598121)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 塚野千尋 (70524255)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 遠山育夫 (20207533)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 小野賢二郎 (70377381)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. 中山隆宏 (00532821)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 矢吹悌 (70756121)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 坂下泰浩 (10972119)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 赤池孝章 (20231798)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 三木裕明 (80302602)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 松永哲郎 (00723206)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 片平正人 (70211844)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. TOKUDA Maki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. KATAOKA Shotaro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 堀亜紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Murakami Kazuma 村上 一馬

MURAKAMI Kazuma 村上 一馬

Research Projects

Research Products

Co-Researchers

Exploring supersulfide that mediates energy metabolism and redox signaling

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神経変性疾患における超硫黄化アミロイドの役割に関する国際共同研究Principal Investigator

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Supramolecular behavior and dynamic capture of metastable amyloid aggregatesArea Organizer

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Supramolecular behavior and dynamic capture of meta-aggregatesPrincipal Investigator

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[Amyloid and protein] Comprehensive search and validation of meta-aggregates by molecular evolutionary methodPrincipal Investigator

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Structural chemistry of intracellular recognition by nucleic acid aptamers and brain barrier permeation strategies for the treatment of neurodegenerative diseasesPrincipal Investigator

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Development of highly sensitive detection method for supersulfide amyloid using nucleic acid probe and exosomePrincipal Investigator

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Bioorganic studies on the genotoxicity of colibactin produced from human microbiome in colorectal cancerPrincipal Investigator

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International research project on nucleic acid aptamers and their exosome-based application to therapeutics for synucleinopathyPrincipal Investigator

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Very early diagnosis of Alzheimer's disease by the toxic oligomer specific antibody of amyloid beta

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Unified comprehension of chemical communication by natural PKC ligands and development of new medicinal seeds

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Structural organic chemistry in inhibitory mechanism of amyloid beta oligomerizationPrincipal Investigator

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Search for novel target molecules of intracellular amyloid betaPrincipal Investigator

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Murakami Kazuma 村上一馬

MURAKAMI Kazuma 村上一馬