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Murakami Kazuma  村上 一馬

… Alternative Names

MURAKAMI Kazuma  村上 一馬

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Researcher Number 80571281
Other IDs
  • ORCIDhttps://orcid.org/0000-0003-3152-1784
Affiliation (Current) 2025: 京都大学, 農学研究科, 准教授
Affiliation (based on the past Project Information) *help 2015 – 2025: 京都大学, 農学研究科, 准教授
2013 – 2015: 京都大学, (連合)農学研究科(研究院), 准教授
2013: 京都大学, 大学院・農学研究科, 准教授
2013: 京都大学, 大学院農学研究科, 准教授
2012: 京都大学, (連合)農学研究科(研究院), 助教
2012: 京都大学, 大学院・農学研究科, 助教
2010 – 2011: 京都大学, 農学研究科, 助教
Review Section/Research Field
Principal Investigator
Transformative Research Areas, Section (III) / Medium-sized Section 37:Biomolecular chemistry and related fields / Bioorganic chemistry / Basic Section 37020:Chemistry and chemical methodology of biomolecules-related / Basic Section 38040:Bioorganic chemistry-related / Biomolecular chemistry / ケミカルバイオロジー
Except Principal Investigator
Bioproduction chemistry/Bioorganic chemistry / Basic Section 52020:Neurology-related / Broad Section H / Medium-sized Section 37:Biomolecular chemistry and related fields / Science and Engineering / Bioorganic chemistry
Keywords
Principal Investigator
神経変性疾患 / 国際共同研究 / エクソソーム / アミロイドβ / アプタマー / アルツハイマー病 / 核酸医薬 / NMR / オリゴマー / アミロイド … More / ドラッグデリバリーシステム / 計算科学 / 有機合成化学 / 標的探索 / 漢方生薬 / 核酸アプタマー / 凝集 / 超硫黄分子 / 女性活躍 / アウトリーチ / 若手支援 / 研究推進 / 分子進化 / 高速AFM / RNA結合タンパク質 / 診断薬 / ペプチド合成 / 超硫黄 / αシヌクレイン / 大腸がん / 抗菌活性 / 片利共生 / プロバイオティクス / ヒューミマイシン / コリバクチン / 天然物化学 / バイオーム分子 / 腸内細菌 / 代謝 / 生薬 / 天然物バンク / 有機化学 / 質量分析 / 脳神経疾患 / siRNA / 磁性ビーズ / ビオチン化 / シグナル伝達 / MS/MS / トリテルペノイド / 構造決定 / カギカズラ / トリテルペン / チョウトウコウ / 単離構造決定 / インスリン受容体 / ビタミンC / 酸化ストレス / ラジカル / 光親和性標識 / スーパーオキシドラジカル / 細胞質SOD / アルキン / アジド / フイスゲン反応 / プロドラッグ / 白金 / Huisgen反応 / ジアミノピペリン酸 / RNA / アミロイド β … More
Except Principal Investigator
アルツハイマー病 / 有機化学 / アミロイドβ / 抗体 / 毒性オリゴマー / 脳神経疾患 / アプリシアトキシン / プロテインキナーゼC / アルツハイマー / オリゴマー / フラボノイド / 毒性ターン / 凝集 / レカネマブ / プロトフィブリル / 酸化ストレス / 過酸化脂質ラジカル / エネルギー代謝 / 超硫黄カテネーション / 超硫黄分子 / 2量体 / ジスルフィド架橋 / 分子内ジスルフィド架橋 / 抗毒性ターン特異抗体 / がん細胞増殖抑制 / ヒト免疫不全ウイルス / マクラマイシン / CH/π相互作用 / 酵素 / 薬理学 / 癌 / シグナル伝達 / HIV / アロタケタール / 機械学習 / ホルボールエステル / 発がんプロモーター / プロテインキナーゼC / 神経細胞毒性 / ノックインマウス / 核酸アプタマー / 診断 / 脳脊髄液 / ラジカル / 硫黄 / 固体NMR / アミロイド / 光アフィニティーラベリング / 毒性コンホマー / 抗ターン抗体 / シナプス毒性 / クルクミン / タキシフォリン / βアミロイド / Aβ42 / カテコール / 凝集抑制 Less
  • Research Projects

    (19 results)
  • Research Products

    (188 results)
  • Co-Researchers

    (28 People)
  •  Elucidation of the pathological significance of Abeta protofibrils in Alzheimer's disease using human biological samples

    • Principal Investigator
      小野 賢二郎
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52020:Neurology-related
    • Research Institution
      Kanazawa University
  •  Exploring supersulfide that mediates energy metabolism and redox signaling

    • Principal Investigator
      赤池 孝章
    • Project Period (FY)
      2024 – 2028
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Review Section
      Broad Section H
    • Research Institution
      Tohoku University
  •  International research project on the role of amyloid supersulfide in neurodegenerative diseasesPrincipal Investigator

    • Principal Investigator
      村上 一馬
    • Project Period (FY)
      2024 – 2028
    • Research Category
      Fund for the Promotion of Joint International Research (International Collaborative Research)
    • Review Section
      Medium-sized Section 37:Biomolecular chemistry and related fields
    • Research Institution
      Kyoto University
  •  [Amyloid and protein] Comprehensive search and validation of meta-aggregates by molecular evolutionary methodPrincipal Investigator

    • Principal Investigator
      村上 一馬
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Transformative Research Areas (B)
    • Review Section
      Transformative Research Areas, Section (III)
    • Research Institution
      Kyoto University
  •  Supramolecular behavior and dynamic capture of metastable amyloid aggregatesArea Organizer

    • Area Organizer
      村上 一馬
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Transformative Research Areas (B)
  •  Supramolecular behavior and dynamic capture of meta-aggregatesPrincipal Investigator

    • Principal Investigator
      村上 一馬
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Transformative Research Areas (B)
    • Review Section
      Transformative Research Areas, Section (III)
    • Research Institution
      Kyoto University
  •  Structural chemistry of intracellular recognition by nucleic acid aptamers and brain barrier permeation strategies for the treatment of neurodegenerative diseasesPrincipal Investigator

    • Principal Investigator
      村上 一馬
    • Project Period (FY)
      2023 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
    • Research Institution
      Kyoto University
  •  Development of highly sensitive detection method for supersulfide amyloid using nucleic acid probe and exosomePrincipal Investigator

    • Principal Investigator
      村上 一馬
    • Project Period (FY)
      2022 – 2023
    • Research Category
      Grant-in-Aid for Transformative Research Areas (A)
    • Review Section
      Transformative Research Areas, Section (III)
    • Research Institution
      Kyoto University
  •  Bioorganic studies on the genotoxicity of colibactin produced from human microbiome in colorectal cancerPrincipal Investigator

    • Principal Investigator
      Murakami Kazuma
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 38040:Bioorganic chemistry-related
    • Research Institution
      Kyoto University
  •  International research project on nucleic acid aptamers and their exosome-based application to therapeutics for synucleinopathyPrincipal Investigator

    • Principal Investigator
      Murakami Kazuma
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
    • Review Section
      Medium-sized Section 37:Biomolecular chemistry and related fields
    • Research Institution
      Kyoto University
  •  Very early diagnosis of Alzheimer's disease by the toxic oligomer specific antibody of amyloid beta

    • Principal Investigator
      Irie Kazuhiro
    • Project Period (FY)
      2019 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 37:Biomolecular chemistry and related fields
    • Research Institution
      Kyoto University
  •  Unified comprehension of chemical communication by natural PKC ligands and development of new medicinal seeds

    • Principal Investigator
      Irie Kazuhiro
    • Project Period (FY)
      2017 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Science and Engineering
    • Research Institution
      Kyoto University
  •  Structural organic chemistry in inhibitory mechanism of amyloid beta oligomerizationPrincipal Investigator

    • Principal Investigator
      Murakami Kazuma
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Young Scientists (A)
    • Research Field
      Bioorganic chemistry
    • Research Institution
      Kyoto University
  •  Search for novel target molecules of intracellular amyloid betaPrincipal Investigator

    • Principal Investigator
      Murakami Kazuma
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Biomolecular chemistry
    • Research Institution
      Kyoto University
  •  Novel Preventive Strategy for Alzheimer's Disease Based on the Toxic Conformation Theory of Amyloid beta

    • Principal Investigator
      Irie Kazuhiro
    • Project Period (FY)
      2014 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Bioorganic chemistry
    • Research Institution
      Kyoto University
  •  Identification of amyloid beta aggregation inhibitors in a traditional herbal medicine Uncaria rhynchophylla and their inhibitory mechanismPrincipal Investigator

    • Principal Investigator
      MURAKAMI Kazuma
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Bioorganic chemistry
    • Research Institution
      Kyoto University
  •  33S solid-state NMR analysis of methionine radical inducing cytotoxicity of amyloid-beta protein

    • Principal Investigator
      MASUDA YUICHI
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Bioproduction chemistry/Bioorganic chemistry
    • Research Institution
      Tohoku University
  •  Development of RNA aptamer against toxic Aβ oligomerPrincipal Investigator

    • Principal Investigator
      MURAKAMI Kazuma
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      ケミカルバイオロジー
    • Research Institution
      Kyoto University
  •  Development of medicinal seeds for Alzheimer's disease based on the structural analysis of toxic oligomers of amyloid beta

    • Principal Investigator
      IRIE Kazuhiro
    • Project Period (FY)
      2009 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Bioproduction chemistry/Bioorganic chemistry
    • Research Institution
      Kyoto University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation Book Patent

  • [Book] New Tide of Natural Product Chemistry (Chapter 15: High-Throughput Searches for Natural Products as Aggregation Modulators of Amyloidogenic Proteins)2023

    • Author(s)
      Kazuma Murakami
    • Total Pages
      356
    • Publisher
      Springer Nature
    • ISBN
      9789819917136
    • Data Source
      KAKENHI-PROJECT-20K05849
  • [Book] Diet and Nutrition in Dementia and Cognitive Decline: Potential role of vitamin C in the prevention of Alzheimer’s disease2014

    • Author(s)
      Murakami, K. et al.
    • Publisher
      Elsevier
    • Data Source
      KAKENHI-PROJECT-25850080
  • [Book] タンパク質の異常凝集とその防御・修復機構に関する研究会報告(VI)2013

    • Author(s)
      村上一馬ら
    • Total Pages
      5
    • Publisher
      京都大学原子炉実験所
    • Data Source
      KAKENHI-PROJECT-25850080
  • [Book] 遺伝子医学MOOK21号「最新ペプチド合成技術とその創薬研究への応用」:固体NMRおよびESRによるアミロイド β の立体構造解析と毒性ターン構造特異抗体の開発2012

    • Author(s)
      村上 一馬
    • Total Pages
      6
    • Publisher
      メディカル ドゥ
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Book] 固体NMR およびESR によるアミロイド β の立体構造解析と毒性ターン構造特異抗体の開発, 遺伝子医学MOOK21 号「最新ペプチド合成技術とその創薬研究への応用」2012

    • Author(s)
      村上一馬, 増田裕一, *入江一浩
    • Publisher
      メディカルドゥ
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Book] 遺伝子医学MOOK第21巻「最新ペプチド合成技術とその創薬研究への応用」(木曽良明編)2012

    • Author(s)
      村上一馬,増田裕一,入江一浩
    • Data Source
      KAKENHI-PROJECT-24780108
  • [Book] タンパク質の異常凝集とその防御・修復機構に関する研究会報告(IV)2011

    • Author(s)
      村上一馬
    • Total Pages
      5
    • Publisher
      京都大学原子炉実験所
    • Data Source
      KAKENHI-PROJECT-22603006
  • [Book] 遺伝子医学MOOK21号「最新ペプチド合成技術とその創薬研究への応用」2011

    • Author(s)
      村上一馬, 他2名
    • Publisher
      株式会社メディカルドゥ
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Book] タンパク質の異常凝集とその防御・修復機構に関する研究会報告(III)2010

    • Author(s)
      村上一馬
    • Total Pages
      5
    • Publisher
      アミロイドβ異常凝集における「折れ曲がり」の役割
    • Data Source
      KAKENHI-PROJECT-22603006
  • [Journal Article] 腸内細菌生産天然物による創薬研究の新展開2023

    • Author(s)
      村上一馬
    • Journal Title

      アグリバイオ

      Volume: 7 (5) Pages: 58-60

    • Data Source
      KAKENHI-PROJECT-20K05849
  • [Journal Article] Detection of Dietary Chalcone and Flavonoid Metabolites in Mice Using UPLC-MS/MS and Their Modulatory Effects on Amyloid β Aggregation2023

    • Author(s)
      Taniwa Kota, Murakami Kazuma, Sakaguchi Yoshiki, Izuo Naotaka, Hanaki Mizuho, Sampa Nobuaki, Kume Toshiaki, Shimizu Takahiko, Irie Kazuhiro
    • Journal Title

      Journal of Agricultural and Food Chemistry

      Volume: 71 Issue: 39 Pages: 14289-14299

    • DOI

      10.1021/acs.jafc.3c02598

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26221202, KAKENHI-PROJECT-22K19607
  • [Journal Article] 統計解析を駆使した生物活性物質の探索法-アミロイド蛋白質の凝集を阻害するファンクショナルフードを例として-2023

    • Author(s)
      村上一馬
    • Journal Title

      Functional Food Research

      Volume: -

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K05849
  • [Journal Article] 神経疾患に対する核酸医薬:アプタマー医薬2023

    • Author(s)
      村上一馬
    • Journal Title

      脳神経内科

      Volume: -

    • Data Source
      KAKENHI-PROJECT-20KK0126
  • [Journal Article] Aptamers targeting amyloidogenic proteins and their emerging role in neurodegenerative diseases2022

    • Author(s)
      Murakami Kazuma、Izuo Naotaka、Bitan Gal
    • Journal Title

      Journal of Biological Chemistry

      Volume: 298 Issue: 1 Pages: 101478-101478

    • DOI

      10.1016/j.jbc.2021.101478

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K16006, KAKENHI-PROJECT-20KK0126, KAKENHI-PROJECT-22H04922
  • [Journal Article] Lysine-targeting inhibition of amyloid β oligomerization by a green perilla-derived metastable chalcone in vitro and in vivo.2022

    • Author(s)
      Murakami, K., Sakaguchi, Y., Taniwa, K., Izuo, N., Hanaki, M., Kawase, T., Hirose, K., Nagao, C., Mizoguchi, K., Shimizu, T., Irie, K.
    • Journal Title

      RSC Chem. Biol.

      Volume: 3 Issue: 12 Pages: 1380-1396

    • DOI

      10.1039/d2cb00194b

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K19607, KAKENHI-PROJECT-20H03583, KAKENHI-PROJECT-20K16006, KAKENHI-PROJECT-26221202
  • [Journal Article] Interactions of amyloid coaggregates with biomolecules and its relevance to neurodegeneration2022

    • Author(s)
      Murakami K, Ono K.
    • Journal Title

      The FASEB Journal

      Volume: 36 Issue: 9

    • DOI

      10.1096/fj.202200235r

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07965, KAKENHI-PROJECT-22K07514, KAKENHI-PROJECT-20KK0126
  • [Journal Article] Searching for natural products that delay nucleation phase and promote elongation phase of amyloid beta42 toward Alzheimer's disease therapeutics2021

    • Author(s)
      Murakami Kazuma, Horii Shiori, Hanaki Mizuho, Irie Kazuhiro
    • Journal Title

      ACS Chemical Neuroscience

      Volume: 12 Issue: 18 Pages: 3467-3476

    • DOI

      10.1021/acschemneuro.1c00489

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Journal Article] Development of a Novel Alzheimer's Disease Model Based on the Theory of the Toxic-conformer of Amyloid β2021

    • Author(s)
      泉尾直孝、清水孝彦、村上一馬、入江一浩
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 141 Issue: 6 Pages: 843-849

    • DOI

      10.1248/yakushi.20-00251-5

    • NAID

      130008046322

    • ISSN
      0031-6903, 1347-5231
    • Year and Date
      2021-06-01
    • Language
      Japanese
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26221202, KAKENHI-PROJECT-20H03583, KAKENHI-PROJECT-20K16006
  • [Journal Article] アミロイドタンパク質を認識する核酸アプタマー2021

    • Author(s)
      村上一馬、入江一浩
    • Journal Title

      化学と生物

      Volume: 59 Pages: 216-218

    • Data Source
      KAKENHI-PROJECT-26221202
  • [Journal Article] An RNA aptamer with potent affinity for a toxic dimer of amyloid β42 has potential utility for histochemical studies of Alzheimer's disease2020

    • Author(s)
      Murakami Kazuma, Obata Yayoi, Sekikawa Asa, Ueda Haruka, Awano Tatsuya, Takabe Keiji, Takahiko Shimizu, Irie Kazuhiro
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 295 Issue: 15 Pages: 4870-4880

    • DOI

      10.1074/jbc.ra119.010955

    • Description
      in press
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26221202, KAKENHI-PROJECT-16H06194, KAKENHI-PROJECT-20H03583
  • [Journal Article] Synthetic biology based construction of biological activity-related library focused on fungal decalin-containing diterpenoid pyrones2020

    • Author(s)
      1.Tsukada K, Shinki S, Kaneko A, Murakami K, Irie K, Murai M, Miyoshi H, Dan S, Kawaji K, Hayashi H, Kodama E, Hori A, Salim E, Kuraishi T, Hirata N, Kanda Y, Asai T.
    • Journal Title

      Nature Communications

      Volume: 11 Issue: 1 Pages: 1830-1830

    • DOI

      10.1038/s41467-020-15664-4

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K16349, KAKENHI-PROJECT-17H04107, KAKENHI-PROJECT-20K20463, KAKENHI-PROJECT-16H06194, KAKENHI-PUBLICLY-19H04642, KAKENHI-PROJECT-19H03701, KAKENHI-PROJECT-17H05055, KAKENHI-PROJECT-18K19388, KAKENHI-PROJECT-19K17921
  • [Journal Article] Synthesis and physicochemical properties of 20-mer peptide nucleic acid conjugates with testosterone 17β-carboxylic acid2020

    • Author(s)
      Yagita Ryotaro、Murakami Kazuma、Ikeda Hisafumi、Irie Kazuhiro
    • Journal Title

      Tetrahedron Letters

      Volume: 61 Issue: 17 Pages: 151781-151781

    • DOI

      10.1016/j.tetlet.2020.151781

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H06194
  • [Journal Article] Detection of amyloid β oligomers with RNA aptamers in AppNL-G-F/NL-G-F Mice: a model of Arctic Alzheimer’s disease2020

    • Author(s)
      Obata Yayoi、*Murakami Kazuma、Kawase Taiji、Hirose Kenji、Izuo Naotaka、Shimizu Takahiko、*Irie Kazuhiro
    • Journal Title

      ACS Omega

      Volume: 5 Issue: 34 Pages: 21531-21537

    • DOI

      10.1021/acsomega.0c02134

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H06194, KAKENHI-PROJECT-20H03583, KAKENHI-PROJECT-26221202
  • [Journal Article] Synthetic and biochemical studies on the effect of persulfidation on disulfide dimer models of amyloid β42 at position 35 in Alzheimer's etiology2020

    • Author(s)
      Murakami Kazuma, Kato Haruka, Hanaki Mizuho, Monobe Yoko, Akagi Ken-ichi, Kawase Taiji, Hirose Kenji, Irie Kazuhiro
    • Journal Title

      RSC Advances

      Volume: 10 Issue: 33 Pages: 19506-19512

    • DOI

      10.1039/d0ra03429k

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26221202, KAKENHI-PROJECT-16H06194
  • [Journal Article] Evaluation of Toxic Amyloid β42 Oligomers in Rat Primary Cerebral Cortex Cells and Human iPS-derived Neurons Treated with 10-Me-Aplog-1, a New PKC Activator2020

    • Author(s)
      Murakami Kazuma、Yoshimura Mayuko、Nakagawa Shota、Kume Toshiaki、Kondo Takayuki、Inoue Haruhisa、Irie Kazuhiro
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 21 Issue: 4 Pages: 1179-1179

    • DOI

      10.3390/ijms21041179

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07119, KAKENHI-PLANNED-17H06405, KAKENHI-PROJECT-17K16121
  • [Journal Article] Synthetic and biophysical studies on the toxic conformer in amyloid β with the E22Δ mutation in Alzheimer pathology2020

    • Author(s)
      Murakami K, Yamaguchi T, Izuo N, Kume T, Hara H, Irie K.
    • Journal Title

      ACS Chem Neurosci.

      Volume: 11 Issue: 19 Pages: 3017-3024

    • DOI

      10.1021/acschemneuro.0c00331

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07119, KAKENHI-PROJECT-16H06194
  • [Journal Article] Three structural features of functional food components and herbal medicine with amyloid β42 anti-aggregation properties2019

    • Author(s)
      Murakami Kazuma, Irie Kazuhiro
    • Journal Title

      Molecules

      Volume: 24 Issue: 11 Pages: 2125-2125

    • DOI

      10.3390/molecules24112125

    • NAID

      120006644072

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26221202, KAKENHI-PROJECT-16H06194
  • [Journal Article] An App knock-in mouse inducing the formation of a toxic conformer of Aβ as a model for evaluating only oligomer-induced cognitive decline in Alzheimer's disease2019

    • Author(s)
      Izuo Naotaka, Murakami Kazuma, Fujihara Yoshitaka, Maeda Masahiro, Saito Takashi, Saido C. Takaomi, Irie Kazuhiro, Shimizu Takahiko
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 515 Issue: 3 Pages: 462-467

    • DOI

      10.1016/j.bbrc.2019.05.131

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Journal Article] Synthesis and biochemical characterization of quasi-stable trimer models of full-length amyloid β40 with a toxic conformation2019

    • Author(s)
      Irie Yumi、Hanaki Mizuho、Murakami Kazuma、Imamoto Tsuneo、Furuta Takumi、Kawabata Takeo、Kawase Taiji、Hirose Kenji、Monobe Yoko、Akagi Ken-ichi、Yanagita Ryo C.、Irie Kazuhiro
    • Journal Title

      Chemical Communications

      Volume: 55 Issue: 2 Pages: 182-185

    • DOI

      10.1039/c8cc08618d

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26221202, KAKENHI-PROJECT-18H02554
  • [Journal Article] Amyloid β toxic conformer has dynamic localization in the human inferior parietal cortex in absence of amyloid plaques2018

    • Author(s)
      Kageyama Yusuke、Saito Atsushi、Pletnikova Olga、Rudow Gay L.、Irie Yumi、An Yang、Murakami Kazuma、Irie Kazuhiro、Resnick Susan M.、Fowler David R.、Martin Lee J.、Troncoso Juan C.
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 16895-16895

    • DOI

      10.1038/s41598-018-35004-3

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Journal Article] アミロイドβ「毒性コンホマー」を標的にしたアルツハイマー病の治療・診断法の開発2018

    • Author(s)
      泉尾直孝、清水孝彦、村上一馬、入江一浩
    • Journal Title

      医薬品医療機器レギュラトリーサイエンス

      Volume: 49 Pages: 312-318

    • Data Source
      KAKENHI-PROJECT-26221202
  • [Journal Article] Role of the carboxy groups of triterpenoids in their inhibition of the nucleation of amyloid β42 required for forming toxic oligomers2018

    • Author(s)
      Murakami Kazuma、Yoshioka Takuya、Horii Shiori、Hanaki Mizuho、Midorikawa Satohiro、Taniwaki Shinji、Gunji Hiroki、Akagi Ken-ichi、Kawase Taiji、Hirose Kenji、Irie Kazuhiro
    • Journal Title

      Chemical Communications

      Volume: 54 Issue: 49 Pages: 6272-6275

    • DOI

      10.1039/c8cc03230k

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26221202, KAKENHI-PROJECT-16H06194
  • [Journal Article] Mechanistic analyses of the suppression of amyloid β42 aggregation by apomorphine2018

    • Author(s)
      Mizuho Hanaki, Kazuma Murakami, Sumie Katayama, Ken-ichi Akagi, Kazuhiro Irie
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 26 Issue: 8 Pages: 1538-1546

    • DOI

      10.1016/j.bmc.2018.01.028

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Journal Article] 食品・生薬成分によるアミロイドβ42の凝集抑制機構の系統的解析2017

    • Author(s)
      村上一馬,入江一浩
    • Journal Title

      Dementia Japan

      Volume: 31 Pages: 351-360

    • Data Source
      KAKENHI-PROJECT-16H06194
  • [Journal Article] 食品・生薬成分によるアミロイドβ42の凝集抑制機構の系統的解析2017

    • Author(s)
      村上一馬、入江一浩
    • Journal Title

      日本認知症学会誌

      Volume: 31 Pages: 351-360

    • Data Source
      KAKENHI-PROJECT-26221202
  • [Journal Article] A toxic conformer of Aβ42 with a turn at 22-23 is a novel therapeutic target for Alzheimer’s disease2017

    • Author(s)
      Naotaka Izuo, Chihiro Kasahara, Kazuma Murakami, Toshiaki Kume, Masahiro Maeda, Kazuhiro Irie, Koutaro Yokote, Takahiko Shimizu
    • Journal Title

      Sci. Rep.

      Volume: 7 Issue: 1 Pages: 11811-11811

    • DOI

      10.1038/s41598-017-11671-6

    • NAID

      120006368174

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26221202, KAKENHI-PROJECT-17H01558, KAKENHI-PROJECT-15K07965, KAKENHI-PROJECT-16J05570, KAKENHI-PROJECT-15K19279
  • [Journal Article] Synthetic models of quasi-stable amyloid β40 oligomers with significant neurotoxicity2017

    • Author(s)
      Yumi Irie, Kazuma Murakami, Mizuho Hanaki, Yusuke Hanaki, Takashi Suzuki, Yoko Monobe, Tomoyo Takai, Ken-ichi Akagi, Taiji Kawase, Kenji Hirose, Kazuhiro Irie
    • Journal Title

      ACS Chem. Neurosci.

      Volume: 8 Issue: 4 Pages: 807-816

    • DOI

      10.1021/acschemneuro.6b00390

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Journal Article] Semisynthesis and structure-activity studies of Uncarinic acid C Isolated from Uncaria rhynchophylla as a specific inhibitor of the nucleation phase in amyloid β42 aggregation2016

    • Author(s)
      Takuya Yoshioka, Kazuma Murakami, Kyohei Ido, Mizuho Hanaki, Kanoko Yamaguchi, Satohiro Midorikawa, Shinji Taniwaki, Hiroki Gunji, Kazuhiro Irie
    • Journal Title

      J. Nat. Prod.

      Volume: 79 Issue: 10 Pages: 2521-2529

    • DOI

      10.1021/acs.jnatprod.6b00392

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Journal Article] Monoclonal antibody with conformational specificity for a toxic conformer of amyloid β42 and its application toward the Alzheimer's disease diagnosis2016

    • Author(s)
      Kazuma Murakami, Maki Tokuda, Takashi Suzuki, Yumi Irie, Mizuho Hanaki, Naotaka Izuo, Yoko Monobe, Ken-ichi Akagi, Ryotaro Ishii, Harutsugu Tatebe, Takahiko Tokuda, Masahiro Maeda, Toshiaki Kume, Takahiko Shimizu, Kazuhiro Irie
    • Journal Title

      Sci. Rep.

      Volume: 6 Issue: 1 Pages: 29038-29038

    • DOI

      10.1038/srep29038

    • NAID

      120005774689

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26221202, KAKENHI-PROJECT-26293165, KAKENHI-PROJECT-26462283, KAKENHI-PROJECT-16K14254, KAKENHI-PROJECT-15K07965, KAKENHI-PROJECT-15K09322, KAKENHI-PROJECT-15K19279, KAKENHI-PROJECT-16J05570
  • [Journal Article] Structural insights into mechanisms for inhibiting amyloid β42 aggregation by non-catechol-type flavonoids2016

    • Author(s)
      Mizuho Hanaki, Kazuma Murakami, Ken-ichi Akagi, Kazuhiro Irie*
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 24 Issue: 2 Pages: 304-313

    • DOI

      10.1016/j.bmc.2015.12.021

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Journal Article] Synthesis and characterization of the amyloid β40 dimer model with a linker at position 30 adjacent to the intermolecular β-sheet region2015

    • Author(s)
      Kazuma Murakami, Takashi Suzuki, Mizuho Hanaki, Yoko Monobe, Ken-ichi Akagi, Kazuhiro Irie*
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 466 Issue: 3 Pages: 463-467

    • DOI

      10.1016/j.bbrc.2015.09.051

    • NAID

      120005679859

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Journal Article] アルツハイマー病様神経毒性におけるアミロイドβコンホマーの役割2015

    • Author(s)
      泉尾直孝*、村上一馬、久米利明、前田雅弘、入江一浩、清水孝彦
    • Journal Title

      基礎老化研究

      Volume: 39 Pages: 29-34

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Journal Article] Conformation-specific antibodies to target amyloid beta oligomers and their application to immunotherapy for Alzheimer's disease2014

    • Author(s)
      Kazuma Murakami
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: 78 Issue: 8 Pages: 1293-1305

    • DOI

      10.1080/09168451.2014.940275

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Journal Article] Structure–Activity Relationship for (+)-Taxifolin Isolated from Silymarin as an Inhibitor of Amyloid β Aggregation2013

    • Author(s)
      Sato, M., Murakami, K., (他5名), Irie, K
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 77 Issue: 5 Pages: 1100-1103

    • DOI

      10.1271/bbb.120925

    • NAID

      10031177604

    • ISSN
      0916-8451, 1347-6947
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Journal Article] Site-specific inhibitory mechanism for amyloid-β42 aggregation by catechol-type flavonoids targeting the Lys-residues2013

    • Author(s)
      Sato, M., Murakami, K., Ikubo, H., Uno, M., Nakagawa, Y., Katayama, S., Akagi, K.-i., Masuda, Y., Takegoshi, K., *Irie, K
    • Journal Title

      J.Biol.Chem

      Volume: 288 Issue: 32 Pages: 23212-23224

    • DOI

      10.1074/jbc.m113.464222

    • NAID

      120005477416

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21248015, KAKENHI-PROJECT-24780108
  • [Journal Article] Intracellular accumulation of toxic turn amyloid-β is associated with endoplasmic reticulum stress in Alzheimer's disease2013

    • Author(s)
      Soejima, N., Ohyagi, Y., (他6名), Murakami, K., Irie, K., (他5名)
    • Journal Title

      Curr. Alzheimer Res

      Volume: 10 Pages: 11-20

    • URL

      http://www.eurekaselect.com/106388/article

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Journal Article] A drug screening platform for Alzheimer's disease with intracellular Aβ oligomers using patient-specific iPSCs2013

    • Author(s)
      Kondo, T., (他24名), Murakami, K., Irie, K., Klein, W. L., Mori, H., Asada, T., Takahashi, R., Iwata, N., Yamanaka, S., Inoue, H
    • Journal Title

      Cell Stem Cell

      Volume: 12 Issue: 4 Pages: 487-496

    • DOI

      10.1016/j.stem.2013.01.009

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21248015, KAKENHI-PLANNED-22129006, KAKENHI-ORGANIZER-23111001, KAKENHI-PLANNED-23111002, KAKENHI-PROJECT-23249049, KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-23592093, KAKENHI-PROJECT-24220009, KAKENHI-PROJECT-24500408, KAKENHI-PROJECT-24590040, KAKENHI-PROJECT-24700367, KAKENHI-PROJECT-24790260, KAKENHI-PROJECT-24790276, KAKENHI-PUBLICLY-25123709, KAKENHI-PROJECT-25290018, KAKENHI-PROJECT-25460341, KAKENHI-PUBLICLY-23110535, KAKENHI-PUBLICLY-23123510
  • [Journal Article] Non-toxic conformer of Aβ42 may suppress Aβ42-induced toxicity in rat primary neurons : implications for the novel therapeutic strategy of Alzheimer's disease2013

    • Author(s)
      Izuo, N., Murakami, K., (他3名), Shimizu, T., Akaike, A., Irie, K., Kume, T
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 438 Issue: 1 Pages: 1-5

    • DOI

      10.1016/j.bbrc.2013.05.106

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21248015, KAKENHI-PROJECT-24390139, KAKENHI-PROJECT-24590111, KAKENHI-PROJECT-25460095, KAKENHI-PROJECT-25670036
  • [Journal Article] アミロイド β の毒性ターン構造を認識する抗体の開発2012

    • Author(s)
      村上 一馬
    • Journal Title

      神経内科

      Volume: 77 Pages: 179-184

    • Data Source
      KAKENHI-PROJECT-21248015
  • [Journal Article] アミロイド β の「毒性コンホマー」形成とGlu22位における遺伝性変異2012

    • Author(s)
      村上 一馬
    • Journal Title

      Dementia Japan

      Volume: 26 Pages: 311-318

    • Data Source
      KAKENHI-PROJECT-21248015
  • [Journal Article] Lack of the Consensus Sequence Necessary for Tryptophan Prenylation in the ComX Pheromone Precursor2012

    • Author(s)
      F. Tsuji, A. Ishihara, A. Nakagawa, M. Okada, S. Kitamura, K. Kanamaru, Y. Masuda, K. Murakami, K. Irie, and Y. Sakagami.
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 76 Issue: 8 Pages: 1492-1496

    • DOI

      10.1271/bbb.120206

    • NAID

      10031065914

    • ISSN
      0916-8451, 1347-6947
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23658098, KAKENHI-PROJECT-24688011, KAKENHI-PROJECT-24780108
  • [Journal Article] Early accumulation of intracellular fibrillar oligomers and late congophilic amyloid angiopathy in mice expressing the Osaka intra-Aβ APP mutation2012

    • Author(s)
      Kulic, L., (他10名), Shimizu, T., Murakami, K., Irie, K., (他4名)
    • Journal Title

      Transl. Psychiatry

      Volume: 2 Issue: 11 Pages: e183-e183

    • DOI

      10.1038/tp.2012.109

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Journal Article] Cytoplasmic superoxide radicals as contributing factors to intracellular Aβ oligomerization in Alzheimer's disease2012

    • Author(s)
      Kazuma Murakami, 他1名
    • Journal Title

      Communicative & Integrative Biology

      Volume: 5(3)(印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22603006
  • [Journal Article] Toxicity in rat primary neuron through the cellular oxidative stress induced by the turn formation 22 and 23 of AB422012

    • Author(s)
      Naotaka Izuo
    • Journal Title

      ACS Chemycal Neuroscience

      Volume: 3(9) Issue: 9 Pages: 647-681

    • DOI

      10.1021/cn300033k

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-10J04068, KAKENHI-PROJECT-21248015, KAKENHI-PROJECT-23790083, KAKENHI-PROJECT-24390139, KAKENHI-PROJECT-24590111
  • [Journal Article] Stimulation of the Amyloidogenic Pathway by Cytoplasmic Superoxide Radicals in an Alzheimer's Disease Mouse Model2012

    • Author(s)
      Murakami, K., Murata, N., Noda, Y., Irie, K., Shirasawa, T., Shimizu, T
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 76 Issue: 6 Pages: 1098-1103

    • DOI

      10.1271/bbb.110934

    • NAID

      10030817824

    • ISSN
      0916-8451, 1347-6947
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21248015, KAKENHI-PROJECT-22603006
  • [Journal Article] Vitamin C restores behavioral deficits and Aβ oligomerization without affecting plaque formation in a mouse model of Alzheimer's disease2011

    • Author(s)
      Kazuma Murakami, 他6名
    • Journal Title

      J.Alzheimers Dis.

      Volume: 26 Issue: 1 Pages: 7-18

    • DOI

      10.3233/jad-2011-101971

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Journal Article] SOD1 (cupper/zinc superoxide dismutase) deficiency drives amyloid β protein oligomerization and memory loss in mouse model of Alzheimer's disease2011

    • Author(s)
      Murakami, K., (他8名), Irie, K., Shirasawa, T., Shimizu, T
    • Journal Title

      J. Biol. Chem

      Volume: 286 Issue: 52 Pages: 44557-44568

    • DOI

      10.1074/jbc.m111.279208

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21248015, KAKENHI-PROJECT-22300118, KAKENHI-PROJECT-22603006
  • [Journal Article] Insulin receptor mutation results in insulin resistance and hyperinsulinemia but does not exacerbate Alzheimer's-like phenotypes in mice2011

    • Author(s)
      Kazuma Murakami, 他6名
    • Journal Title

      Biophys.Biochem.Res.Commun.

      Volume: 409 Issue: 1 Pages: 34-39

    • DOI

      10.1016/j.bbrc.2011.04.101

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Journal Article] Insulin receptor mutation results in insulin resistance and hyperinsulinemia but does not exacerbate Alzheimer's-like phenotypes in mice2011

    • Author(s)
      Kazuma Murakami
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: (印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22603006
  • [Journal Article] Vitamin C restores behavioral deficits and Aβ oligomerization without affecting plaque formation in a mouse model of Alzheimer's disease2011

    • Author(s)
      Kazuma Murakami
    • Journal Title

      Journal of Alzheimer's Disease

      Volume: (印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22603006
  • [Journal Article] Formation of the 42-mer amyloid β radical and the therapeutic role of superoxide dismutase in Alzheimer's disease2011

    • Author(s)
      Kazuma Murakami
    • Journal Title

      Journal of Amino Acids

      Volume: 2011

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22603006
  • [Journal Article] Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 232010

    • Author(s)
      Murakami, K., (他8名), Shimizu, T., Irie, K
    • Journal Title

      ACS Chem. Neurosci

      Volume: 1 Issue: 11 Pages: 747-756

    • DOI

      10.1021/cn100072e

    • NAID

      130004504903

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Journal Article] Silymarin Attenuated the Amyloid .BETA. Plaque Burden and Improved Behavioral Abnormalities in an Alzheimer's Disease Mouse Model2010

    • Author(s)
      Murata, N., Murakami, K., Ozawa, Y., Kinoshita, N., Irie, K., Shirasawa, T., Shimizu T
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 74 Issue: 11 Pages: 2299-2306

    • DOI

      10.1271/bbb.100524

    • NAID

      10027561730

    • ISSN
      0916-8451, 1347-6947
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Journal Article] The turn formation at positions 22 and 23 in the 42-mer amyloid β peptide : The emerging role in the pathogenesis of Alzheimer's disease2010

    • Author(s)
      Kazuma Murakami
    • Journal Title

      Geriatr. Gerontol. Int. 10(suppl.1)(in press)

    • NAID

      10027273706

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Journal Article] E22Δ mutation in amyloid β-protein promotes β-sheet transformation, radical production, and synaptotoxicity, but not neurotoxicity2010

    • Author(s)
      Suzuki, T., Murakami, K., (他7名), Irie, K
    • Journal Title

      Int. J. Alzheimers Dis

      Volume: 431320 Issue: 1

    • DOI

      10.4061/2011/431320

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Journal Article] The turn formation at positions 22 and 23 in the 42-mer amyloid beta peptide : the emerging role in the pathogenesis of Alzheimer's disease2010

    • Author(s)
      Murakami, K., Masuda, Y., Shirasawa, T., Shimizu, T., Irie, K
    • Journal Title

      Geriatr. Gerontol. Int

      Volume: 10 Issue: s1

    • DOI

      10.1111/j.1447-0594.2010.00598.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Journal Article] Monoclonal antibody against the toxic turn of the 42-residue amyloid β peptide at positions 22 and 232010

    • Author(s)
      Kazuma Murakami
    • Journal Title

      ACS Chem.Neurosci.

      Volume: 1 Pages: 747-756

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Patent] RNAアプタマー2024

    • Inventor(s)
      村上一馬
    • Industrial Property Rights Holder
      村上一馬
    • Industrial Property Rights Type
      特許
    • Filing Date
      2024
    • Overseas
    • Data Source
      KAKENHI-PROJECT-23K26786
  • [Patent] RNAアプタマー2023

    • Inventor(s)
      村上一馬
    • Industrial Property Rights Holder
      村上一馬
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2023-023603
    • Filing Date
      2023
    • Data Source
      KAKENHI-PROJECT-20KK0126
  • [Patent] アミロイドβの22位及び23位のターン構造を極めて特異的に認識する抗体(学内整理番号:4718)2015

    • Inventor(s)
      入江一浩,村上一馬,清水孝彦,泉尾直孝,清藤 勉
    • Industrial Property Rights Holder
      入江一浩,村上一馬,清水孝彦,泉尾直孝,清藤 勉
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-12-14
    • Overseas
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Patent] アミロイドβの22位及び23位のターン構造を極めて特異的に認識する抗体2014

    • Inventor(s)
      入江一浩,村上一馬,清水孝彦,泉尾直孝,清藤 勉
    • Industrial Property Rights Holder
      入江一浩,村上一馬,清水孝彦,泉尾直孝,清藤 勉
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-251898
    • Filing Date
      2014-12-12
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Patent] アミロイド β のターン構造を認識する抗体2011

    • Inventor(s)
      入江一浩, 村上一馬, 増田裕一, 清水孝彦,白 澤卓二, 清藤 勉
    • Industrial Property Rights Holder
      入江一浩, 村上一馬, 増田裕一, 清水孝彦,白 澤卓二, 清藤 勉
    • Industrial Property Rights Type
      特許
    • Filing Date
      2011-04-21
    • Overseas
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Patent] Antibody recognizing tumstructure in amyloid β2010

    • Inventor(s)
      Kazuhiro Irie, Kazuma Murakami, Yuichi Masuda, Takahiko Shimizu, Takuji Shirasawa, Tsutomu Seito
    • Industrial Property Rights Holder
      Kazuhiro Irie, Kazuma Murakami, Yuichi Masuda, Takahiko Shimizu, Takuji Shirasawa, Tsutomu Seito
    • Industrial Property Rights Type
      特許
    • Filing Date
      2010-10-18
    • Acquisition Date
      2014-04-29
    • Overseas
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Presentation] αシヌクレインを認識するRNAアプタマー2024

    • Author(s)
      村上一馬
    • Organizer
      第13回 DSANJ Digital Bio Conference 2024
    • Data Source
      KAKENHI-PROJECT-23K26786
  • [Presentation] Natural products derived from microbiota in the intestine as pharmaceutical resources (accepted)2024

    • Author(s)
      Kazuma Murakami
    • Organizer
      The 51st Naito Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K05849
  • [Presentation] αシヌクレインを標的とした中分子核酸の開発と神経治療への応用2024

    • Author(s)
      村上一馬、泉尾直孝、長尾知生子、水口賢司、Esha Chawla、Gal Bitan
    • Organizer
      日本農芸化学会2024年度大会
    • Data Source
      KAKENHI-PROJECT-23K26786
  • [Presentation] 核酸研究から見えてきた新たなAD病態:核酸アプタマー医薬の創製と応用2023

    • Author(s)
      村上一馬
    • Organizer
      第64回日本神経学会学術大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K26786
  • [Presentation] アミロイドタンパク質を認識する核酸アプタマー2023

    • Author(s)
      村上一馬
    • Organizer
      日本薬学会北陸支部特別講演会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20KK0126
  • [Presentation] 多様なアミロイド凝集体による神経変性メカニズムの解明(シンポジウム企画)2023

    • Author(s)
      村上一馬、小野賢二郎、矢吹悌、中山隆宏
    • Organizer
      第64回日本神経病理学会総会学術研究会/第66回日本神経化学会大会合同大会
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-23H03849
  • [Presentation] アミロイド凝集を阻害する天然物の論理的探索法2023

    • Author(s)
      村上一馬
    • Organizer
      第19回ファンクショナルフード学会学術集会(先端シンポジウム)
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K05849
  • [Presentation] 新しい分析ツールでひも解く次代のmisfolding病研究(シンポジウム企画)2023

    • Author(s)
      小野賢二郎、菅瀬謙治、有本博一、村上一馬
    • Organizer
      第42回日本認知症学会学術集会
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-23H03849
  • [Presentation] アミロイド蛋白質を認識する核酸アプタマー2023

    • Author(s)
      村上一馬
    • Organizer
      第14回タンパク質の異常凝集とその防御・修復機構に関する研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20KK0126
  • [Presentation] Development of RNA aptamers that recognizes amyloid key structures2022

    • Author(s)
      Kazuma Murakami
    • Organizer
      Special seminar in Neurology at UCLA
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20KK0126
  • [Presentation] アミロイドタンパク質を認識する核酸アプタマーの創製と応用2022

    • Author(s)
      村上一馬
    • Organizer
      日本農芸化学会2022年度大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20KK0126
  • [Presentation] Synthesis of conformation-restricted analogues of amyloid persulfide toward their application to nucleic acid medicine2022

    • Author(s)
      Kazuma Murakami, Masayoshi Mochizuki, Taku Yoshiya, Naotaka Izuo
    • Organizer
      Redox Week in Sendai 2002 (4th International Conference on Persulfide and Sulfur Metabolism in Biology and Medicine)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-22H05564
  • [Presentation] 超硫黄化アミロイドに特異的な核酸プローブとエクソソームを用いた高感度検出法の開発2022

    • Author(s)
      村上一馬
    • Organizer
      学術変革領域研究(A)新興硫黄生物学が拓く生命原理変革(硫黄生物学)第2回領域会議
    • Data Source
      KAKENHI-PUBLICLY-22H05564
  • [Presentation] アンチセンス治療を指向した長鎖ペプチド核酸の合成研究2021

    • Author(s)
      村上一馬、八木田凌太郎、池田 壽文、入江一浩
    • Organizer
      日本農芸化学会2021年度大会(仙台、オンライン)
    • Data Source
      KAKENHI-PROJECT-16H06194
  • [Presentation] Suppression of toxic amyloid β42 oligomers in rat primary cerebral cortex cells and human iPS-derived neurons treated with 10-Me-Aplog-1, a new PKC activator2021

    • Author(s)
      Murakami Kazuma、Yoshimura Mayuko、Nakagawa Shota、Kume Toshiaki、Kondo Takayuki、Inoue Haruhisa、Irie Kazuhiro
    • Organizer
      2021 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2021) virtual
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-17H06405
  • [Presentation] 青ジソに含まれるアミロイドβ42 の凝集阻害物質・DDC の代謝物の合成と活性2021

    • Author(s)
      谷輪厚太、村上一馬、坂口嘉紀、入江一浩
    • Organizer
      日本農芸化学会2021年度大会(仙台、オンライン)
    • Data Source
      KAKENHI-PROJECT-16H06194
  • [Presentation] RNA aptamers recognize amyloid oligomers with in AppNL-G-F/NL-G-F mice as a model of Arctic Alzheimer disease2020

    • Author(s)
      Murakami Kazuma, Obata Yayoi, Kawase Taiji, Hirose Kenji, Izuo Naotaka, Shimizu Takahiko, Irie Kazuhiro
    • Organizer
      Alzheimer's Association International Conference 2020 (Virtual)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06194
  • [Presentation] アミロイドβの凝集阻害機構に基づいた天然物ライブラリーの分類(ポスター発表演題選出)2020

    • Author(s)
      村上一馬、堀井詩織、定光達斗、花木瑞穂、郡司祐樹、入江一浩
    • Organizer
      日本農芸化学会2020年度大会(福岡)*講演要旨の公表のみ
    • Data Source
      KAKENHI-PROJECT-16H06194
  • [Presentation] Aβ42のパースルフィド化に関する化学研究2020

    • Author(s)
      村上一馬、加藤春花、花木瑞穂、物部容子、赤木謙一、川瀬泰司、廣瀬賢治、入江一浩
    • Organizer
      第39回日本認知症学会学術集会(名古屋、ハイブリッド)
    • Data Source
      KAKENHI-PROJECT-16H06194
  • [Presentation] アミロイドβ42の毒性オリゴマーを認識するRNAアプタマーの開発2020

    • Author(s)
      村上一馬、小畑弥生、関川あさ、上田遥、川瀬泰司、廣瀬賢治、泉尾直孝、清水孝彦、入江一浩
    • Organizer
      第62回天然有機化合物討論会(口頭、オンライン)
    • Data Source
      KAKENHI-PROJECT-16H06194
  • [Presentation] アミロイドβの凝集を抑制する食品・生薬成分の作用機構2019

    • Author(s)
      入江一浩、村上一馬
    • Organizer
      2019年度日本農芸化学会大会(東京農大、東京)
    • Invited
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] アミロイドβ42のプロトフィブリルを認識するRNAアプタマー(学会奨励賞候補演題(基礎))2019

    • Author(s)
      村上一馬、小畑弥生、関川あさ、上田遥、泉尾直孝、粟野達也、高部圭司、清水孝彦、入江一浩
    • Organizer
      第38回日本認知症学会学術集会(東京)
    • Data Source
      KAKENHI-PROJECT-16H06194
  • [Presentation] 準安定なアミロイドβの毒性オリゴマーモデルの合成と機能解析2019

    • Author(s)
      入江由美、村上一馬、花木瑞穂、花木祐輔、鈴木天志、今本恒雄、古田 巧、川端猛夫、川瀬泰司、廣瀬賢治、柳田 亮、入江一浩
    • Organizer
      第61回天然有機化合物討論会(広島国際会議場、広島市)
    • Data Source
      KAKENHI-PROJECT-19H00921
  • [Presentation] Strategy for development of RNA aptamers that target the toxic oligomers of Aβ422019

    • Author(s)
      Murakami Kazuma, Obata Yayoi, Sekikawa Asa, Ueda Haruka, Izuo Naotaka, Awano Tatsuya, Takabe Keiji, Shimizu Takahiko, Irie Kazuhiro
    • Organizer
      Alzheimer's Association International Conference 2019 (Los Angeles, USA)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06194
  • [Presentation] アミロイドβ40の3量体モデルの合成と神経細胞毒性2019

    • Author(s)
      入江由美、花木瑞穂、村上一馬、今本恒雄、古田 巧、川端猛夫、川瀬泰司、廣瀬賢治、柳田 亮、入江一浩
    • Organizer
      第38回日本認知症学会学術集会(京王プラザホテル、東京)
    • Data Source
      KAKENHI-PROJECT-19H00921
  • [Presentation] アミロイドβ42の毒性オリゴマーに対する核酸アプタマーの開発研究と脳組織染色への応用2019

    • Author(s)
      村上一馬、小畑弥生、関川あさ、上田 遥、泉尾直孝、粟野達也、高部圭司、清水孝彦、入江一浩
    • Organizer
      2019年度日本農芸化学会大会(東京農大、東京)優秀発表
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] 分子内ジスルフィド結合によるアミロイドβ 42の毒性配座固定アナログの合成と生化学的機能解析2019

    • Author(s)
      松島由佳、村上一馬、入江一浩
    • Organizer
      第9回 認知症研究を知る若手研究者の集まり(ホテルヘリテイジ・リゾート、熊谷市)
    • Data Source
      KAKENHI-PROJECT-19H00921
  • [Presentation] 分子内ジスルフィド結合形成によるアミロイドβ42の毒性配座モデルの合成と機能解析2019

    • Author(s)
      松島由佳、村上一馬、花木瑞穂、粟野達也、高部圭司、柳田 亮、入江一浩
    • Organizer
      2019年度日本農芸化学会大会(東京農大、東京)
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] Strategy for development of RNA aptamers targeting the toxic oligomers of Aβ422019

    • Author(s)
      Kazuma Murakami
    • Organizer
      UCLA Integrative Center for Neural Repair Seminar (Mini-symposium: "Oligomers in Alzheimer's disease: Elucidation of disease mechanisms and development of therapeutics")
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06194
  • [Presentation] Evaluation system of amyloid beta precursor protein processing in rat primary cortical neurons treated with PKC activators2019

    • Author(s)
      Yoshimura Mayuko、Murakami Kazuma、Kume Toshiaki、Irie Kazuhiro
    • Organizer
      新学術領域研究「化学コミュニケーションのフロンティア」第1回国際シンポジウム(一橋大学一橋講堂、東京)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-17H06405
  • [Presentation] アミロイドβの凝集を抑える天然物の3つの特徴2019

    • Author(s)
      村上一馬、入江一浩
    • Organizer
      第2回日本食品科学工学会関西支部大会「脳機能に影響を与える食品成分」シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H06194
  • [Presentation] アミロイドβの毒性オリゴマー形成阻害能を有する生薬化合物のカルボキシ基の役割2018

    • Author(s)
      堀井詩織,村上一馬,花木瑞穂,粟野達也,高部圭司,川瀬泰司,廣瀬賢治,入江一浩
    • Organizer
      2019年度日本農芸化学会大会
    • Data Source
      KAKENHI-PROJECT-16H06194
  • [Presentation] 分子内ジスルフィド結合形成によるアミロイドβの毒性コンホメーションの制御2018

    • Author(s)
      松島由佳、村上一馬、花木瑞穂、粟野達也、高部圭司、柳田 亮、入江一浩
    • Organizer
      第37回日本認知症学会学術集会(ロイトン札幌・札幌市教育文化会館、札幌市)
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] 青ジソに含まれるアミロイドβ42の凝集阻害物質の作用機構とマウスにおける生体内代謝2018

    • Author(s)
      坂口嘉紀,村上一馬,花木瑞穂,泉尾直孝,小澤裕介,粟野達也,高部圭司,川瀬泰司,廣瀬賢治,三羽伸明,久米利明,清水孝彦,入江一浩
    • Organizer
      2018年度日本農芸化学会大会
    • Data Source
      KAKENHI-PROJECT-16H06194
  • [Presentation] 青ジソに含まれるアミロイドβ42の凝集阻害物質の作用機構とマウスにおける生体内代謝2018

    • Author(s)
      坂口嘉紀、村上一馬、花木瑞穂、泉尾直孝、小澤祐介、粟野達也、高部圭司、川瀬泰司、廣瀬賢治、三羽伸明、久米利明、清水孝彦、入江一浩
    • Organizer
      2018年度日本農芸化学会大会(大会トピックス賞)(名城大学、名古屋市)
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] アミロイドβ42の毒性2量体モデルから形成されるプロトフィブリルを標的としたRNAアプタマーの開発2018

    • Author(s)
      小畑弥生、村上一馬、関川あさ、入江一浩
    • Organizer
      2018年度日本農芸化学会大会(名城大学、名古屋市)
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] アミロイドβ42の2量体モデル由来の毒性オリゴマーに対するRNAアプタマー2018

    • Author(s)
      小畑弥生、村上一馬、関川あさ、粟野達也、髙部圭司、入江一浩
    • Organizer
      日本核酸医薬学会第4回年会(九州大学医学部百年講堂、福岡市)
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] 天然物によるアミロイドβの毒性オリゴマー形成阻害機構2018

    • Author(s)
      村上一馬,吉岡卓也,堀井詩織,花木瑞穂,緑川諭弘,谷脇慎治,郡司祐樹,赤木謙一,川瀬泰司,廣瀬賢治,入江一浩
    • Organizer
      第37回日本認知症学会学術集会
    • Data Source
      KAKENHI-PROJECT-16H06194
  • [Presentation] アポモルフィンによるアミロイドβ42凝集抑制機構の解析2018

    • Author(s)
      花木瑞穂、村上一馬、片山寿美枝、赤木謙一、入江一浩
    • Organizer
      2018年度日本農芸化学会大会(名城大学、名古屋市)
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] RNA aptamers targeting the toxic oligomers of Aβ42 and their application to immunohistochemistry2018

    • Author(s)
      Murakami Kazuma、Obata Yayoi、Sekikawa Asa、Ueda Haruka、Izuo Naotaka、Awano Tatsuya、Takabe Keiji、Shimizu Takahiko、Irie Kazuhiro
    • Organizer
      The 45th International Symposium on Nucleic Acids Chemistry (Kyoto University Clock Tower Centennial Hall, Kyoto, Japan)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] 漢方由来ウンカリン酸 C によるアミロイド β42 核形成阻害メカニズム2017

    • Author(s)
      吉岡卓也、村上一馬、花木瑞穂、緑川諭弘、谷脇慎治、郡司祐樹、川瀬泰司、廣瀬賢治、入江一浩
    • Organizer
      2017年度日本農芸化学会大会
    • Place of Presentation
      京都女子大学(京都府京都市)
    • Year and Date
      2017-03-20
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] アミロイドβの毒性配座理論と抗体創製2017

    • Author(s)
      村上一馬、入江一浩
    • Organizer
      認知症研究を知る若手研究者の集まり2017(湯の宿木もれび、大津市)
    • Invited
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] アミロイドβ40の毒性オリゴマーモデル2017

    • Author(s)
      入江由美、村上一馬、花木瑞穂、花木祐輔、鈴木天志、物部容子、高井朋代、赤木謙一、川瀬泰司、廣瀬賢治、入江一浩
    • Organizer
      2017年度日本農芸化学会大会
    • Place of Presentation
      京都女子大学(京都府京都市)
    • Year and Date
      2017-03-20
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] オリゴマー仮説の視点からバイオマーカーを考える:アミロイドβの毒性配座理論2017

    • Author(s)
      村上一馬、入江一浩
    • Organizer
      第36回日本認知症学会学術集会(ANAクラウンプラザホテル金沢、金沢市)
    • Invited
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] Inhibitory mechanism of amyloid β aggregation by traditional herbal medicine and functional food components2017

    • Author(s)
      Kazuma Murakami and Kazuhiro Irie
    • Organizer
      Zhejiang University-Kyoto University Joint Workshop
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06194
  • [Presentation] 漢方由来ウンカリン酸によるアミロイドβ42核形成阻害メカニズム2017

    • Author(s)
      吉岡卓也,村上一馬,花木瑞穂,緑川諭弘,谷脇慎治,郡司祐樹,川瀬泰司,廣瀬賢治,入江一浩
    • Organizer
      2017年度日本農芸化学会大会
    • Place of Presentation
      京都女子大学(京都市)
    • Data Source
      KAKENHI-PROJECT-16H06194
  • [Presentation] アミロイドβ「毒性コンホマー」を標的にしたアルツハイマー病の治療・診断法の開発2017

    • Author(s)
      泉尾直孝、久米利明、村上一馬、徳田隆彦、前田雅弘、入江一浩、清水孝彦
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-25
    • Invited
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] 生薬チョウトウコウに含まれるアミロイドβオリゴマー形成阻害物質の同定と作用機構2017

    • Author(s)
      村上一馬、吉岡卓也、井戸恭平、花木瑞穂、山口加乃子、緑川諭弘、谷脇慎治、郡司祐樹、赤木謙一、川瀬泰司、廣瀬賢治、入江一浩
    • Organizer
      第59回天然有機化合物討論会(札幌市民ホール、札幌市)
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] 神経細胞毒性を有する準安定なアミロイドβの2量体モデルの合成とイオンモビリティー質量分析法による構造解析2017

    • Author(s)
      入江一浩、入江由美、村上一馬、花木瑞穂、花木祐輔、川瀬泰司、廣瀬賢治、徳田隆彦、前田雅弘
    • Organizer
      第35回メディシナルケミストリーシンポジウム(豊田講堂、名古屋市)
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] アミロイドβの毒性配座抗体とその診断応用2016

    • Author(s)
      村上一馬
    • Organizer
      天然有機化合物と創薬R&D
    • Place of Presentation
      筑波大学筑波キャンパス
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K12744
  • [Presentation] アミロイドβのラジカル化:アルツハイマー病態におけるSOD1の役割2016

    • Author(s)
      村上一馬、清水孝彦、入江一浩
    • Organizer
      第11回レドックス・ライフイノベーションシンポジウム
    • Place of Presentation
      お茶の水女子大学(東京都文京区)
    • Year and Date
      2016-03-17
    • Invited
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] 天然ポリフェノールによるAβ42凝集阻害機構の解明とアルツハイマー病予防の可能性2016

    • Author(s)
      村上一馬、入江一浩
    • Organizer
      第35回日本認知症学会学術集会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2016-12-03
    • Invited
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] ウンカリン酸によるアミロイドβ凝集核形成の選択的阻害2016

    • Author(s)
      吉岡卓也、村上一馬、井戸恭平、花木瑞穂、山口加乃子、緑川諭弘、谷脇慎治、郡司祐樹、入江一浩
    • Organizer
      第35回日本認知症学会学術集会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2016-12-02
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] 天然ポリフェノールによるAβ42凝集阻害機構の解明とアルツハイマー病予防の可能性2016

    • Author(s)
      村上一馬,入江一浩
    • Organizer
      第35回日本認知症学会学術集会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H06194
  • [Presentation] Characterization of the monoclonal antibody (24B3) highly recognizing the toxic turn of amyloid β42 and its application to diagnosis for Alzheimer’s disease2016

    • Author(s)
      Kazuma Murakami, Mizuho Hanaki, Maki Tokuda, Ken-ichi kagi, Ryotaro Ishii, Harutsugu Tatebe, Takahiko Tokuda, Masahiro Maeda, Naotaka Izuo, Takahiko Shimizu, Kazuhiro Irie
    • Organizer
      The 8th Takeda Science Foundation Symposium on PharmaSciences “Biomolecule-based Medicinal Science: Featuring Mid-Size Drugs”
    • Place of Presentation
      Takeda Pharmaceutical Company, Ltd. (Suita, Japan)
    • Year and Date
      2016-01-21
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] Passive immunization with the toxic conformer of Aβ ameliorated behavioral abnormalities in Alzheimer’s-like model without affecting senile plaque deposition2016

    • Author(s)
      泉尾直孝、村上一馬、久米利明、入江一浩、横手幸太郎、清水孝彦
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-03-10
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] チョウトウコウに含まれるウンカリン酸Cおよびその誘導体のアミロイドβ凝集阻害活性2016

    • Author(s)
      吉岡卓也、村上一馬、花木瑞穂、緑川諭弘、谷脇慎治、郡司裕樹、入江一浩
    • Organizer
      2016年度日本農芸化学会大会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-03-28
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] アミロイドβの毒性コンホマーにきわめて特異的な抗体の開発とアルツハイマー病診断への応用2016

    • Author(s)
      村上一馬、徳田真樹、鈴木天志、入江由美、花木瑞穂、柳田亮、物部容子、赤木謙一、石井亮太郎、建部陽嗣、徳田隆彦、前田雅弘、久米利明、泉尾直孝、清水孝彦、入江一浩
    • Organizer
      2016年度日本農芸化学会大会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-03-28
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] Aβ42の22-23位におけるターン構造はAβ42誘発神経毒性を調節する2016

    • Author(s)
      泉尾直孝、久米利明、村上一馬、前田雅弘、入江一浩、清水孝彦
    • Organizer
      日本基礎老化学会大会
    • Place of Presentation
      伊勢原市民文化会館(神奈川県伊勢原市)
    • Year and Date
      2016-05-27
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] アミロイドβ40の2量体モデルの合成と神経細胞毒性2016

    • Author(s)
      入江由美、村上一馬、鈴木天志、花木瑞穂、花木祐輔、物部容子、高井朋代、赤木謙一、入江一浩
    • Organizer
      第35回日本認知症学会学術集会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2016-12-02
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] Identification of the “toxic conformer” of amyloid β and its pathogenic contribution of Alzheimer's disease2016

    • Author(s)
      Naotaka Izuo, Kazuma Murakami, Toshiaki Kume, Masahiro Maeda, Kazuhiro Irie, Takahiko Shimizu
    • Organizer
      2016 Spring International Conference of the Korean Society for Gerontology
    • Place of Presentation
      Convention Hall (Daegu, Korea)
    • Year and Date
      2016-06-16
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] アミロイドβの毒性コンホマーを極めて特異的に認識する抗体の開発とAD診断への応用2015

    • Author(s)
      村上一馬、花木瑞穂、赤木謙一、石井亮太郎、徳田隆彦、前田雅弘、泉尾直孝、清水孝彦、入江一浩
    • Organizer
      第34回日本認知症学会学術集会
    • Place of Presentation
      リンクステーションホール青森(青森県青森市)
    • Year and Date
      2015-10-02
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] アミロイドβペプチドの毒性配座理論に基づいた構造特異抗体の開発と診断薬への応用2015

    • Author(s)
      村上一馬、入江一浩
    • Organizer
      第47回若手ペプチド夏の勉強会
    • Place of Presentation
      信州塩尻・天然温泉アスティかたおか(長野県塩尻市)
    • Year and Date
      2015-08-11
    • Invited
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] アミロイドβ42ダイマーの合成と活性評価2015

    • Author(s)
      徳田真樹、村上一馬、鈴木天志、花木瑞穂、岩崎真実、久米利明、入江一浩
    • Organizer
      2015年度日本農芸化学会大会
    • Place of Presentation
      岡山大学津島キャンパス(岡山市)
    • Year and Date
      2015-03-27
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] Structural insight into the inhibitory mechanism of amyloid β42 aggregation by non-catechol-type flavonoids2015

    • Author(s)
      Mizuho Hanaki, Kazuma Murakami, Ken-ichi Akagi, Kazuhiro Irie
    • Organizer
      2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015)
    • Place of Presentation
      Hilton Hawaiian Villege (Honolulu, USA)
    • Year and Date
      2015-12-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] Aβ 毒性コンホマーの選択的除去は老人斑に影響せずアルツハイマー病症状を改善する2015

    • Author(s)
      泉尾直孝、村上一馬、前田雅弘、久米利明、横手幸太郎、入江一浩、清水孝彦
    • Organizer
      第34回日本認知症学会学術集会
    • Place of Presentation
      リンクステーションホール青森(青森県青森市)
    • Year and Date
      2015-10-02
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] アミロイドβの「毒性コンホマー」を標的とした受動免疫療法はアルツハイマー病モデルの神経症状を改善する2015

    • Author(s)
      泉尾直孝、村上一馬、徳田隆彦、久米利明、赤池昭紀、白澤卓二、横手幸太郎、入江一浩、清水孝彦
    • Organizer
      日本基礎老化学会大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2015-06-13
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] アミロイドβの毒性配座理論に基づいた構造特異抗体の開発と診断薬への応用2015

    • Author(s)
      村上一馬、入江一浩
    • Organizer
      第8回たんぱく質の異常凝集とその防御・修復機構に関する研究会
    • Place of Presentation
      京都大学原子炉実験所(大阪府熊取町)
    • Year and Date
      2015-11-19
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] SOFAST-HMQC NMR を用いた非カテコール型フラボノイドによるアミロイドβの凝集抑制機構の解析2015

    • Author(s)
      花木瑞穂、村上一馬、赤木謙一、入江一浩
    • Organizer
      2015年度日本農芸化学会中部・関西支部合同大会
    • Place of Presentation
      富山県立大学(富山県射水市)
    • Year and Date
      2015-09-20
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] Characterization of monoclonal antibodies against the toxic turn of amyloid β42 and their application to diagnosis for Alzheimer’s disease2015

    • Author(s)
      Kazuma Murakami, Mizuho Sato-Hanaki, L. M. Moro, G. Giaccone, F. Tagliavini, Ken-ichi Akagi, Ryotaro Ishii, Takahiko Tokuda, Masahiko Maeda, Naotaka Izuo, Takahiko Shimzu, Kazuhiro Irie
    • Organizer
      2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015)
    • Place of Presentation
      Hilton Hawaiian Villege (Honolulu, USA)
    • Year and Date
      2015-12-15
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] Aβ毒性コンホマーの選択的除去は老人班蓄積を阻害せずにアルツハイマー病モデルマウスの行動異常を改善する2015

    • Author(s)
      泉尾直孝、村上一馬、前田雅弘、久米利明、横手幸太郎、入江一浩、清水孝彦
    • Organizer
      第38回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-04
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] 非カテコール型フラボノイドによるアミロイドβの凝集抑制機構2015

    • Author(s)
      花木瑞穂、村上一馬、赤木謙一、入江一浩
    • Organizer
      第57回天然有機化合物討論会
    • Place of Presentation
      神奈川県民ホール(神奈川県横浜市)
    • Year and Date
      2015-09-09
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] Pathophysiological activities of the “toxic conformer” and the “non-toxic conformer” of amyloid β-induced neurotoxicity2015

    • Author(s)
      泉尾直孝、久米利明、村上一馬、入江一浩、泉 安彦、赤池昭紀、横手幸太郎、清水孝彦
    • Organizer
      第88回日本薬理学会年会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Year and Date
      2015-03-19
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] アミロイドβを標的としたアルツハイマー病の新しい治療戦略2014

    • Author(s)
      村上一馬
    • Organizer
      日本農芸化学会中部支部 第172回例会(若手シンポジウム)「化学の視点から拓く天然物・生命科学研究」
    • Place of Presentation
      信州大学農学部(長野県南箕輪村)
    • Year and Date
      2014-11-22
    • Invited
    • Data Source
      KAKENHI-PROJECT-25850080
  • [Presentation] Synthesis and biological activities of the Abeta40 dimer with toxic conformation2014

    • Author(s)
      Kazuhiro Irie, Kazuma Murakami, Takashi Suzuki, Mizuho Sato, Mami Iwasaki, Toshiaki Kume
    • Organizer
      Alzheimer’s Association International Conference 2014
    • Place of Presentation
      Bella Center A/S (Copenhagen, Denmark)
    • Year and Date
      2014-07-14
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] Inhibitors for Aβ42 aggregation in a traditional herbal medicine Uncaria rhynchophylla2014

    • Author(s)
      Kazuma Murakami, Kyohei Ido, Mizuho Sato, Kanoko Yamaguchi, and Kazuhiro Irie
    • Organizer
      Alzheimer's Association International Conference 2014
    • Place of Presentation
      Bella Center A/S (Copenhagen, Denmark)
    • Year and Date
      2014-07-14
    • Data Source
      KAKENHI-PROJECT-25850080
  • [Presentation] Vitamin C and silymarin restores Aβ oligomerization and behavioral abnormality in Alzheimer's pathology2013

    • Author(s)
      Murakami, K., Murata, N., Ozawa, Y., Irie, K., Shirasawa, T., Shimizu, T
    • Organizer
      Alzheimer's Association International Conference (AAIC) 2013
    • Place of Presentation
      Boston, USA
    • Year and Date
      2013-07-15
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Presentation] 細胞質酸化ストレスによるアミロイドβオリゴマー形成能および記憶異常の促進2012

    • Author(s)
      村上一馬
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都女子大学
    • Year and Date
      2012-03-24
    • Data Source
      KAKENHI-PROJECT-22603006
  • [Presentation] Specific Inhibitory Mechanism of Aggregation of 42-mer Amyloid-βPeptide by Flavonoids2012

    • Author(s)
      Sato, M., Murakami, K., Ikubo, H., Uno, M., Nakagawa, Y., Katayama, S., Akagi, K., Masuda, Y., Takegoshi, K., Irie, K.
    • Organizer
      IKCOC-12
    • Place of Presentation
      Kyoto(ポスター発表, Poster Number PA-140)
    • Year and Date
      2012-11-13
    • Data Source
      KAKENHI-PROJECT-24780108
  • [Presentation] ポリフェノールによるアミロイドβ の凝集阻害機構2012

    • Author(s)
      入江一浩, 村上一馬, 佐藤瑞穂, 井久保遥子, 宇野真弓, 中川 優, 片山寿美枝, 赤木謙一
    • Organizer
      第31回日本認知症学会学術集会
    • Place of Presentation
      つくば
    • Year and Date
      2012-10-28
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Presentation] カテコール系フラボノイド類によるアミロイドβの凝集抑制機構2012

    • Author(s)
      村上一馬,佐藤瑞穂,井久保遥子,宇野真弓,中川優,片山寿美枝,赤木謙一,増田裕一,竹腰清乃理,入江一浩
    • Organizer
      第54回天然有機化合物討論会
    • Place of Presentation
      東京(口頭発表,講演番号17,査読あり)
    • Year and Date
      2012-09-19
    • Data Source
      KAKENHI-PROJECT-24780108
  • [Presentation] カテコール系フラボノイド類によるアミロイドβの凝集抑制機構2012

    • Author(s)
      村上一馬,佐藤瑞穂,井久保遥子,宇野真弓,中川 優,片山寿美枝,赤木謙一,増田裕一,竹腰清乃理,入江一浩
    • Organizer
      第54回天然有機化合物討論会
    • Place of Presentation
      東京農業大学 世田谷キャンパス
    • Data Source
      KAKENHI-PROJECT-24780108
  • [Presentation] Specific Inhibitory Mechanism of Aggregation of 42-mer Amyloid-beta Peptide by Flavonoids2012

    • Author(s)
      Mizuho Sato, Kazuma Murakami, Haruko Ikubo, Mayumi Uno, Yu Nakagawa, Sumie Katayama, Ken-ichi Akagi, Yuichi Masuda, Kiyonori Takegoshi, and Kazuhiro Irie
    • Organizer
      The 12th International Kyoto Conference on New Aspects of Organic Chemistry
    • Place of Presentation
      Rihga Royal Hotel Kyoto
    • Data Source
      KAKENHI-PROJECT-24780108
  • [Presentation] カテコール系フラボノイド類によるアミロイドβ の凝集抑制機構2012

    • Author(s)
      村上一馬, 佐藤瑞穂, 井久保遥子, 宇野真弓, 中川 優, 片山寿美枝, 赤木謙一, 増田裕一, 竹腰清乃理, 入江一浩
    • Organizer
      第54回天然有機化合物討論会
    • Place of Presentation
      東京
    • Year and Date
      2012-09-19
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Presentation] Monoclonal antibody against a toxic conformer of Aβ42 with a turn at E22-D232012

    • Author(s)
      Irie, K., Murakami, K., Horikoshi-Sakuraba, Y., Kinoshikta, N., Shirasawa, T., Shimizu, T., Tokuda, T
    • Organizer
      Alzheimer's Association International Conference (AAIC) 2012
    • Place of Presentation
      Vancouver, British Columbia, Canada
    • Year and Date
      2012-07-15
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Presentation] 抗酸化ストレスに着目したアルツハイマー病予防の可能性2011

    • Author(s)
      村上一馬
    • Organizer
      京都大学原子炉実験所専門研究会「タンパク質の異常凝集とフォールディング病」
    • Place of Presentation
      京都大学原子炉実験所(大阪)(招待講演)
    • Year and Date
      2011-11-10
    • Data Source
      KAKENHI-PROJECT-22603006
  • [Presentation] E22Δ mutation promotes the formation of toxic conformer in Alzheimer's peptide, Aβ422011

    • Author(s)
      Murakami, K., Suzuki, T., Izuo, N., Kume, T., Akaike, A., Nagata, T., Nishizaki, T., Tomiyama, T., Takuma, H., Mori, H., Irie, K
    • Organizer
      27th International Symposium on the Chemistry of Natural Products, 7th International Conference on Biodiversity
    • Place of Presentation
      Brisbane, Australia
    • Year and Date
      2011-07-11
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Presentation] 大阪変異によるアミロイドβの毒性コンホマー形成能の増大2011

    • Author(s)
      村上一馬
    • Organizer
      第30回日本認知症学会学術集会
    • Place of Presentation
      タワーホール船堀(東京)
    • Year and Date
      2011-11-11
    • Data Source
      KAKENHI-PROJECT-22603006
  • [Presentation] E22Δ mutation promotes the formation of toxic conformer in Alzheimer's peptide, Aβ422011

    • Author(s)
      Kazuma Murakami
    • Organizer
      27th International Symposium on the Chemistry of Natural Products, 7th International Conference on Biodiversity
    • Place of Presentation
      Convention & Exibition Center (Brisbane, Australia)
    • Year and Date
      2011-07-11
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Presentation] アミロイドβ の毒性コンホマーを標的とした立体構造特異的抗体2010

    • Author(s)
      村上一馬, 堀越(櫻庭)優子, 村田 央, 野田義博, 増田裕一, 木下憲明, 初田裕幸, 村山繁雄, 白澤卓二, 清水孝彦, 入江一浩
    • Organizer
      2010年度日本農芸化学会大会
    • Place of Presentation
      東京
    • Year and Date
      2010-03-29
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Presentation] アルツハイマー病と機能性食品因子(Alzheimer's disease and functional foods)2010

    • Author(s)
      Kazuma Murakami
    • Organizer
      Invited Lecturer in Gwangju University
    • Place of Presentation
      Gwangju大学(Gwangju,韓国)
    • Year and Date
      2010-10-13
    • Data Source
      KAKENHI-PROJECT-22603006
  • [Presentation] Structural analysis of toxic conformer of 42-mer amyloid β peptide using ESR spectrometry2010

    • Author(s)
      Kazuma Murakami
    • Organizer
      7^<th> Asia-Pacific EPR/ESR Symposium
    • Place of Presentation
      Convention Center(Jeju,韓国)
    • Year and Date
      2010-10-12
    • Data Source
      KAKENHI-PROJECT-22603006
  • [Presentation] アミロイドβ (Aβ42) の毒性コンホマー特異的抗体の作製2010

    • Author(s)
      村上一馬, 堀越(櫻庭)優子, 村田 央, 野田義博, 増田裕一, 木下憲明, 初田裕幸, 村山繁雄, 白澤卓二, 清水孝彦, 入江一浩
    • Organizer
      第52回天然有機化合物討論会
    • Place of Presentation
      静岡
    • Year and Date
      2010-09-30
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Presentation] アミロイドβの毒性コンホマーを標的とした立体構造特異的抗体[トピックス賞]2010

    • Author(s)
      村上一馬
    • Organizer
      2010年度日本農芸化学大会
    • Place of Presentation
      東京大学駒場キャンパス(東京都)
    • Year and Date
      2010-03-29
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Presentation] Structural analysis of toxic conformer of 42-mer amyloid β peptide using ESR spectrometry2010

    • Author(s)
      Murakami, K. and Irie, K
    • Organizer
      Asia-Pacific EPR/ESR symposium
    • Place of Presentation
      Jeju, Republic of Korea
    • Year and Date
      2010-10-12
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Presentation] アミロイドβ異常凝集における「折れ曲がり」の役割2010

    • Author(s)
      村上一馬
    • Organizer
      京都大学原子炉実験所専門研究会「タンパク質の異常凝集とフォールディング病」
    • Place of Presentation
      京都大学原子炉実験所(大阪)
    • Year and Date
      2010-11-12
    • Data Source
      KAKENHI-PROJECT-22603006
  • [Presentation] SilymarinによるADモデルマウスの行動異常ならびにアミロイドβオリゴマー形成の予防効果2010

    • Author(s)
      村上一馬
    • Organizer
      2010年度日本農芸化学会関西支部大会
    • Place of Presentation
      近畿大学(奈良)
    • Year and Date
      2010-10-02
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Presentation] アミロイドβ(Aβ42)の毒性コンホマー特異的抗体の作製(第52回天然有機化合物討論会奨励賞受賞)2010

    • Author(s)
      村上一馬
    • Organizer
      第52回天然有機化合物討論会
    • Place of Presentation
      グランシップ(静岡)
    • Year and Date
      2010-09-30
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Presentation] Monoclonal antibody against the toxic turn structure of the 42-mer amyloid β peptide2010

    • Author(s)
      Kazuma Murakami
    • Organizer
      2010 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010)
    • Place of Presentation
      Convention Center (Hawaii, USA)
    • Year and Date
      2010-12-18
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Presentation] アミロイドβの毒性ターン構造特異的抗体2010

    • Author(s)
      村上一馬
    • Organizer
      第29回日本認知症学会学術集会
    • Place of Presentation
      ウインク愛知(名古屋)
    • Year and Date
      2010-11-05
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Presentation] Development of a monoclonal antibody against the toxic conformer of the 42-mer amyloid β protein2009

    • Author(s)
      Kazuma Murakami
    • Organizer
      39th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2009-10-18
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Presentation] 酸化ストレスに着目したアミロイドβペプチドの神経細胞毒性発現機構

    • Author(s)
      村上一馬
    • Organizer
      農芸化学奨励賞受賞講演
    • Place of Presentation
      電力ホール(仙台)
    • Data Source
      KAKENHI-PROJECT-22603006
  • [Presentation] アミロイドβの毒性オリゴマー認識薬開発への挑戦

    • Author(s)
      村上一馬
    • Organizer
      新学術領域研究 天然物ケミカルバイオロジー 地区ミニシンポジウム「化学と生物学の壁と打開策:次世代天然物ケミカルバイオロジー研究の開拓へ」
    • Place of Presentation
      理化学研究所鈴木梅太郎記念ホール(和光市)
    • Invited
    • Data Source
      KAKENHI-PROJECT-25850080
  • [Presentation] 酸化ストレスに着目したアミロイドβペプチドの神経細胞毒性発現機構

    • Author(s)
      村上一馬
    • Organizer
      農芸化学会関西支部例会(第483回講演会)
    • Place of Presentation
      京都大学楽友会館(京都市)
    • Invited
    • Data Source
      KAKENHI-PROJECT-25850080
  • [Presentation] ポリフェノールによるアミロイド β の凝集阻害機構

    • Author(s)
      村上一馬ら
    • Organizer
      第3回生理化学ユニットシンポジウム
    • Place of Presentation
      京都大学楽友会館(京都市)
    • Invited
    • Data Source
      KAKENHI-PROJECT-25850080
  • [Presentation] Vitamin C and silymarin restores Aβ oligomerization and behavioral abnormality in Alzheimer’s pathology

    • Author(s)
      Murakami, K. et al.
    • Organizer
      Alzheimer’s Association International Conference 2013
    • Place of Presentation
      Boston Convention Center(Boston MA, USA)
    • Data Source
      KAKENHI-PROJECT-25850080
  • [Presentation] カテコール系フラボノイド類によるアミロイドβの凝集抑制機構

    • Author(s)
      村上 一馬
    • Organizer
      第54回天然有機化合物討論会
    • Place of Presentation
      東京農業大学(東京都世田谷区)
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Presentation] 伝統生薬チョウトウコウに含まれるアミロイドβ凝集抑制物質

    • Author(s)
      村上一馬ら
    • Organizer
      2014年度日本農芸化学会大会
    • Place of Presentation
      明治大学生田キャンパス(川崎市)
    • Data Source
      KAKENHI-PROJECT-25850080
  • [Presentation] ポリフェノールによるアミロイドβ42の凝集抑制機構

    • Author(s)
      村上一馬ら
    • Organizer
      第6回タンパク質の異常凝集とその防御・修復機構に関する研究会
    • Place of Presentation
      京都大学原子炉実験所(大阪府熊取町)
    • Invited
    • Data Source
      KAKENHI-PROJECT-25850080
  • [Presentation] アミロイドβオリゴマーの形成と空間記憶異常における細胞質SODの役割

    • Author(s)
      村上 一馬
    • Organizer
      第31回日本認知症学会学術集会
    • Place of Presentation
      つくば国際会議場(つくば市)
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Presentation] CuZn-SOD loss accelerates the formation of amyloid beta oligomer and memory impairment in Tg2576 mice

    • Author(s)
      Kazuma Murakami
    • Organizer
      Alzheimer's Association International Conference (AAIC) 2012
    • Place of Presentation
      Vancouver Convention Center (Canada)
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Presentation] ポリフェノールによるアミロイドβ42の凝集抑制機構

    • Author(s)
      村上一馬ら
    • Organizer
      第6回タンパク質の異常凝集とその防御・修復機構に関する研究会
    • Place of Presentation
      京都大学原子炉実験所(熊取町)
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Presentation] CuZn-SOD loss accelerates the formation of amyloid β oligomer and memory impairment in Tg2576 mice

    • Author(s)
      Kazuma Murakami
    • Organizer
      Alzheimer's Association International Conference
    • Place of Presentation
      Vancouver Convention Center (Canada)
    • Data Source
      KAKENHI-PROJECT-22603006
  • [Presentation] アミロイド β ペプチドの毒性ターン構造の同定とその構造特異抗体の開発

    • Author(s)
      村上一馬
    • Organizer
      第47回天然物化学談話会
    • Place of Presentation
      阿蘇プラザホテル(熊本)
    • Data Source
      KAKENHI-PROJECT-22603006
  • [Presentation] ビタミンCにおるアルツハイマー病態緩和

    • Author(s)
      村上一馬
    • Organizer
      2013年度日本農芸化学会大会
    • Place of Presentation
      東北大学川内北キャンパス(仙台)
    • Data Source
      KAKENHI-PROJECT-22603006
  • 1.  IRIE Kazuhiro (00168535)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 82 results
  • 2.  SHIMIZU Takahiko (40301791)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 33 results
  • 3.  泉尾 直孝 (50722261)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 2 results
  • 4.  TAKEGOSHI Kiyonori (10206964)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 6 results
  • 5.  KUME Toshiaki (10303843)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 18 results
  • 6.  徳田 隆彦 (80242692)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 9 results
  • 7.  喜田 昭子 (70273430)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  水口 賢司 (50450896)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  小野 賢二郎 (70377381)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 10.  MASUDA YUICHI (90617755)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 11.  IZUMI Shunsuke (90203116)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  柳田 亮 (10598121)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  塚野 千尋 (70524255)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  遠山 育夫 (20207533)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  坂下 泰浩 (10972119)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  中山 隆宏 (00532821)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 17.  矢吹 悌 (70756121)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 18.  赤池 孝章 (20231798)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  松永 哲郎 (00723206)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  三木 裕明 (80302602)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  高田 剛 (20733257)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  片平 正人 (70211844)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  西野 勝俊 (60803492)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  篠原 もえ子 (20584832)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  辻 まゆみ (40155544)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  TOKUDA Maki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  KATAOKA Shotaro
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  堀 亜紀
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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