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Misawa Hidemi  三澤 日出巳

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MISAWA Hidemi  三澤 日出巳

三澤 日出巳  ミサワ ヒデミ

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Researcher Number 80219617
Other IDs
Affiliation (Current) 2022: 慶應義塾大学, 薬学部(芝共立), 教授
Affiliation (based on the past Project Information) *help 2019 – 2022: 慶應義塾大学, 薬学部(芝共立), 教授
2017: 慶応大学, 薬学部, 教授
2016 – 2017: 慶應義塾大学, 薬学部(芝共立), 教授
2008 – 2015: Keio University, 薬学部, 教授
2014: 慶応大学, 薬学部, 教授 … More
2008 – 2011: 慶応義塾大学, 薬学部, 教授
2005: Kyoritsu University of Pharmacy, Pharmacology, Associate Professor, 薬学部, 助教授
2004: 財団法人東京都医学研究機構, 東京都神経科学総合研究所, 主任研究員
2003 – 2004: (財)東京都医学研究機構, 主任研究員
2003: 財団法人東京都医学研究機構, 主任研究員
2002 – 2003: (財)東京都医学研究機構, 東京都神経科学総合研究所, 主任研究員
2002: 財団法人東京都医学研究機構, 東京都神経科学総合研究所, 主任研究員
2002: 財団法人東京都医学研究機構, 東京都神経科学総合研究所, 研究員
2001: 財団法人 東京都医学研究機構, 東京都神経科学総合研究所, 主任研究員
2000 – 2001: (財)東京都医学研究機構, 東京都神経科学総合研究所, 研究員(主任)
1998: 東京都神経科学総研, 研究員
1996 – 1997: (財)東京都神経科学総合研究所, 神経学研究部門, 主任研究員
1995: 東京都神経科学総合研究所, 神経学研究部門, 主事研究員
1993 – 1995: (財)東京都神経科学総合研究所, 神経学研究部門, 主事研究員 Less
Review Section/Research Field
Principal Investigator
Neurochemistry/Neuropharmacology / Neurochemistry/Neuropharmacology / Pharmacology in pharmacy / Basic Section 47040:Pharmacology-related / Biological Sciences
Except Principal Investigator
Biological Sciences / Neurology / Biological pharmacy / Nerve anatomy/Neuropathology / Pharmacology in pharmacy
Keywords
Principal Investigator
アセチルコリン / コリン作動性ニューロン / コリンアセチル転移酵素 / 神経変性疾患 / cDNA / トランスジェニックマウス / 筋萎縮性側索硬化症 / アセチルコリントランスポーター / ノックアウトマウス / 運動ニューロン … More / トランスポーター / 神経変性 / 分子生物学 / 遺伝子改変 / Cre / ニコチン受容体 / 神経伝達物質 / 神経終末 / 遺伝子発現 / 神経損傷 / シナプス小胞 / コリン作動性神経 / コリンアセチル移転酵素 / 連鎖解析 / てんかん / PDZドメイン / 熱性けいれん / マウス遺伝学 / 神経創薬 / 認知症 / アストロサイト / ミクログリア / オステオポンチン / 細胞外マトリクス / 選択的脆弱性 / グリア / 酸化ストレス / 活性酸素 / ミトコンドリア / cholinergic neurons / motor neurons / knockout mouse / oxidative stress / superoxide dismutase / mitochondria / neurodegeneration / Cre recombinase / コリン作動性抗炎症反応 / 神経毒 / 内在性修飾因子 / 免疫ストーム / 迷走神経 / 抗炎症 / 腸炎 / 抗炎症反射 / 脾臓 / 腸管免疫 / 脳・神経 / 炎症 / 薬理学 / 凝集体 / グリアリンパ系 / 伝播 … More
Except Principal Investigator
ALS / 筋萎縮性側索硬化症 / SOD1 / 神経変性疾患 / 運動ニューロン / GluR2 / トランスジェニックマウス / コリンアセチル転移酵素 / グルタミン酸受容体 / AMPA / パーキンソン病 / グリア / 脊髄 / T細胞 / SLURP-1 / Th1 / alpha7 / Treg / α7 nAChR / アロステリック・リガンド / 神経栄養因子 / 遺伝子変異 / スプライシング / 遺伝子ノックアウト / 変異SODトランスジェニックマウス / AMPA受容体 / カルシウム毒性 / glutamate / Calcium / Misfolding / XIAP / p35 / カスパーゼ-9 / アポトーシス / Hsp70 / CHIP / S5a / G93A / 酸化ストレス / パーンソン病 / Parkin / 小胞体ストレス / ATF6α / 遺伝子ノックアウトマウス / MEF / アデノウイルス / AR-JP / PARK 2 / ユビキチンリガーゼ / Pael-R / ノルアドレナリン / NET / プロテアソーム / Rpt3 / コンディショナルノックアウト / モデル動物 / RP t 3 / 26Sプロテアソーム / コンディショナルノックアウトマウス / VAChT-Cre / アルツハイマー病 / タンパク分解 / Cre-lox system / グリア細胞 / 環境 / 脊髄環境 / 細胞外環境 / アセチルコリン / ニコチン受容体 / 樹状細胞 / Th0 / α7 / α7ニコチン受容体 / CD205 / コリン・アセチルトランスフェレース / methyllycaconitine / 扁桃 / 前角細胞 / リボゾーム / 粗面小胞体 / 蛋白合成 / 蛋白折り畳み / RNA / 転写活性 / Amyotrophic lateral sclerosis / Spinal cord / Anterior horn cell / Ribosome / Rough endoplasmic reticulum / Protein synthesis / Protein infolding / アストロサイト / nAChR / Th2 / GTS-21 / DO11.10マウス / T細胞分化 / alpha7 nAChR / 抗原提示細胞 / 制御性T細胞 / エフェクターT細胞 / Th分化 / Th17 / アロステリック・リガンド / 分化 Less
  • Research Projects

    (30 results)
  • Research Products

    (85 results)
  • Co-Researchers

    (64 People)
  •  脳に常在する境界性マクロファージの役割解明とALS治療を目指した実験的介入研究Principal Investigator

    • Principal Investigator
      三澤 日出巳
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47040:Pharmacology-related
    • Research Institution
      Keio University
  •  Involvment of glymphatic system in removing brain waste products in neurodegenerative diseases.Principal Investigator

    • Principal Investigator
      Misawa Hidemi
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47040:Pharmacology-related
    • Research Institution
      Keio University
  •  Crisis management systems by neurons to defend against systemic immune stormsPrincipal Investigator

    • Principal Investigator
      MISAWA HIDEMI
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Pharmacology in pharmacy
    • Research Institution
      Keio University
  •  Role of SLURP-1, an endogenous alpha7 nicotinic acetylcholine receptor allosteric ligand, in T cell differentiation

    • Principal Investigator
      Kawashima Koichiro
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pharmacology in pharmacy
    • Research Institution
      Kitasato University
  •  Elucidating pathomechanism of ALS through the abnormality in astrocytes

    • Principal Investigator
      YAMANAKA Koji
    • Project Period (FY)
      2014 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      Nagoya University
  •  Cell-autonomous and non-cell-autonomous mechanisms of neurodegeneration in ALSPrincipal Investigator

    • Principal Investigator
      Misawa Hidemi
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pharmacology in pharmacy
    • Research Institution
      Keio University
  •  Investigation on the role of nicotinic acetylcholine receptors in regulation of inflammatory and immune responses

    • Principal Investigator
      KAWASHIMA Koichiro
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Kitasato University
  •  Spinal cord environment: elucidating the mechanism of neurodegeneration through glia-neuron interaction

    • Principal Investigator
      Yamanaka Koji
    • Project Period (FY)
      2011 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Nagoya University
      The Institute of Physical and Chemical Research
  •  Elucidating molecular pathology of glial cells in amyotrophic lateral sclerosis

    • Principal Investigator
      YAMANAKA Koji
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      The Institute of Physical and Chemical Research
  •  パエル受容体のドーパミンニューロンの機能維持と変性における役割の解明

    • Principal Investigator
      高橋 良輔
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  The analysis of participation in the ubiquitin proteasome system for understanding the mechanisms of neurodegenerative diseases.

    • Principal Investigator
      TAKAHASHI Ryosuke
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      Kyoto University
  •  Development of novel drugs for improving cognitive impairmentPrincipal Investigator

    • Principal Investigator
      MISAWA Hidemi
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Keio University
  •  小児けいれん感受性遺伝子マウスホモローグのポジショナルクローニングPrincipal Investigator

    • Principal Investigator
      三澤 日出巳
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  ALSマウスモデルの神経変性におけるプロテアソームの役割に関する研究

    • Principal Investigator
      高橋 良輔
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The Institute of Physical and Chemical Research
  •  運動ニューロン特異的遺伝子過剰発現マウスを用いたALSの実験的治療の研究

    • Principal Investigator
      高橋 良輔
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The Institute of Physical and Chemical Research
  •  Generation of cholinergic neuron-specific transgenic and knockout mouse systemPrincipal Investigator

    • Principal Investigator
      MISAWA Hidemi
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Kyoritsu University of Pharmacy
      Tokyo Metropolitan Organization for Medical Research
  •  運動ニューロン特異的遺伝子過剰発現マウスを用いたALSの実験的治療の研究

    • Principal Investigator
      高橋 良輔
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The Institute of Physical and Chemical Research
  •  Amyotrophic lateral sclerosis : on the decreased transcription activity of ribosomal RNA gene and cell degeneration

    • Principal Investigator
      OYANAGI Kiyomitsu
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  運動ニューロン特異的遺伝子発現・ノックアウトシステムの確立

    • Principal Investigator
      高橋 良輔
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      The Institute of Physical and Chemical Research
  •  コリン作動性ニューロン特異的遺伝子発現・ノックアウトシステムの確立Principal Investigator

    • Principal Investigator
      三澤 日出巳
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  運動ニューロン特異的遺伝子発現・ノックアウトシステムの確立

    • Principal Investigator
      高橋 良輔
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      The Institute of Physical and Chemical Research
  •  コリン作動性神経分化に伴う遺伝子発現機構の解明Principal Investigator

    • Principal Investigator
      三澤 日出巳
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience
  •  コリン作動性遺伝子座の発現制御機構の解明Principal Investigator

    • Principal Investigator
      三澤 日出巳
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience
  •  コリン作動性神経分化に伴う遺伝子発現制御機構の解明Principal Investigator

    • Principal Investigator
      三澤 日出巳
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience
  •  コリン作動性神経分化に伴う遺伝子発現制御機構の解明Principal Investigator

    • Principal Investigator
      三澤 日出巳
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience
  •  ヒトのコリンアセチル転移酵素の構造と病態に関する研究Principal Investigator

    • Principal Investigator
      三澤 日出巳
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience
  •  ヒトにおける毛様体神経栄養因子(CNTF)の遺伝的欠損に関する分子遺伝学的研究

    • Principal Investigator
      高橋 良輔
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience
  •  ヒトのコリンアセチル転移酵素の構造と病態に関する研究Principal Investigator

    • Principal Investigator
      三澤 日出巳
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience
  •  神経終末におけるアセチルコリンの生合成及び放出の分子生物学的研究Principal Investigator

    • Principal Investigator
      三澤 日出巳
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience
  •  コリンアセチル転移酵素の遺伝子発現機構の研究Principal Investigator

    • Principal Investigator
      三澤 日出巳
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience

All 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2004 2003 Other

All Journal Article Presentation Book

  • [Book] グッドマン・ギルマン薬理書:薬物治療の基礎と臨床12版2013

    • Author(s)
      三澤日出巳
    • Total Pages
      1409
    • Publisher
      廣川書店
    • Data Source
      KAKENHI-PROJECT-25293020
  • [Book] ブレインサイエンスレビュー2010(認知症のトライアングル仮説とコリン作動性ニューロン02010

    • Author(s)
      三澤日出巳
    • Publisher
      クバプロ
    • Data Source
      KAKENHI-PROJECT-20500340
  • [Journal Article] Competitive inhibition of the high-affinity choline transporter by tetrahydropyrimidine anthelmintics2021

    • Author(s)
      Okuda Takashi、Nomura Yuki、Konishi Asami、Misawa Hidemi
    • Journal Title

      European Journal of Pharmacology

      Volume: 898 Pages: 173986-173986

    • DOI

      10.1016/j.ejphar.2021.173986

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07128
  • [Journal Article] Stagnation of glymphatic interstitial fluid flow and delay in waste clearance in the SOD1-G93A mouse model of ALS2021

    • Author(s)
      Hirose Mikako、Asano Mito、Watanabe-Matsumoto Saori、Yamanaka Koji、Abe Yoichiro、Yasui Masato、Tokuda Eiichi、Furukawa Yoshiaki、Misawa Hidemi
    • Journal Title

      Neuroscience Research

      Volume: 171 Pages: 74-82

    • DOI

      10.1016/j.neures.2020.10.006

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07128, KAKENHI-PROJECT-21K19456
  • [Journal Article] Endogenous neurotoxin-like protein Ly6H inhibits alpha7 nicotinic acetylcholine receptor currents at the plasma membrane.2020

    • Author(s)
      Moriwaki Yasuhiro、Kubo Natsuki、Watanabe Mizuho、Asano Shinsuke、Shinoda Tomoki、Sugino Taro、Ichikawa Daiju、Tsuji Shoutaro、Kato Fusao、Misawa Hidemi
    • Journal Title

      Sci Rep

      Volume: 10 Pages: 11996-11996

    • DOI

      10.1038/s41598-020-68947-7

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07128, KAKENHI-PROJECT-19K07770, KAKENHI-PROJECT-18H02722
  • [Journal Article] Oxidative misfolding of Cu/Zn-superoxide dismutase triggered by non-canonical intramolecular disulfide formation2020

    • Author(s)
      Anzai Itsuki、Tokuda Eiichi、Handa Sumika、Misawa Hidemi、Akiyama Shuji、Furukawa Yoshiaki
    • Journal Title

      Free Radical Biology and Medicine

      Volume: 147 Pages: 187-199

    • DOI

      10.1016/j.freeradbiomed.2019.12.017

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07128, KAKENHI-PUBLICLY-18H04564, KAKENHI-PLANNED-19H05765, KAKENHI-PROJECT-17H06165, KAKENHI-PROJECT-16H04768, KAKENHI-PROJECT-18J12708
  • [Journal Article] Minireview: Divergent roles of α7 nicotinic acetylcholine receptors expressed on antigen-presenting cells and CD4+ T cells in the regulation of T cell differentiation2020

    • Author(s)
      Mashimo Masato、Fujii Takeshi、Ono Shiro、Moriwaki Yasuhiro、Misawa Hidemi、Kawashima Koichiro
    • Journal Title

      International Immunopharmacology

      Volume: 82 Pages: 106306-106306

    • DOI

      10.1016/j.intimp.2020.106306

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06903, KAKENHI-PROJECT-19K07128
  • [Journal Article] Behavioral and electrophysiological evidence for a neuroprotective role of aquaporin-4 in the 5xFAD transgenic mice model2020

    • Author(s)
      Abe Y, Ikegawa N, Yoshida K, Muramatsu K, Hattori S, Murakami M, Tanaka T, Goda W, Hashimoto T, Miyakawa T, Iwatsubo T, Hata J, Niikura T, Yasui M, et al.
    • Journal Title

      Acta Neuropathol. Commun.

      Volume: 8 Pages: 67-67

    • DOI

      10.1186/s40478-020-00936-3

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07364, KAKENHI-PROJECT-19K07128, KAKENHI-PUBLICLY-19H05027, KAKENHI-PLANNED-20H05896, KAKENHI-PROJECT-18H02606, KAKENHI-PROJECT-16H06276
  • [Journal Article] Distinct Roles of α7 nAChRs in Antigen-Presenting Cells and CD4+ T Cells in the Regulation of T Cell Differentiation2019

    • Author(s)
      Mashimo Masato、Komori Masayo、Matsui Yuriko Y.、Murase Mami X.、Fujii Takeshi、Takeshima Shiori、Okuyama Hiromi、Ono Shiro、Moriwaki Yasuhiro、Misawa Hidemi、Kawashima Koichiro
    • Journal Title

      Frontiers in Immunology

      Volume: 10 Pages: 1102-1102

    • DOI

      10.3389/fimmu.2019.01102

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07128
  • [Journal Article] Immunochemical characterization on pathological oligomers of mutant Cu/Zn-superoxide dismutase in amyotrophic lateral sclerosis.2017

    • Author(s)
      Eiichi Tokuda, Itsuki Anzai, Takao Nomura, Keisuke Toichi, Masahiko Watanabe, Shinji Ohara, Seiji Watanabe, Koji Yamanaka, Yuta Morisaki, Hidemi Misawa, and Yoshiaki Furukawa
    • Journal Title

      Molecular neurodegeneration

      Volume: 12 Pages: 2-2

    • DOI

      10.1186/s13024-016-0145-9

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PUBLICLY-15H01566, KAKENHI-PROJECT-16H04768, KAKENHI-PROJECT-26293208, KAKENHI-PROJECT-15K14480, KAKENHI-PROJECT-25860252
  • [Journal Article] Physiological functions of the cholinergic system in immune cells.2017

    • Author(s)
      Fujii Takeshi、Mashimo Masato、Moriwaki Yasuhiro、Misawa Hidemi、Ono Shiro、Horiguchi Kazuhide、Kawashima Koichiro
    • Journal Title

      J. Pharmacol. Sci.

      Volume: 134 Pages: 121-121

    • DOI

      10.1016/j.jphs.2017.05.002

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09375, KAKENHI-PROJECT-17K10626, KAKENHI-PROJECT-15K07969, KAKENHI-PROJECT-15K07979, KAKENHI-PROJECT-16K15129
  • [Journal Article] Expression and function of the cholinergic system in immune cells.2017

    • Author(s)
      Fujii Takeshi、Mashimo Masato、Moriwaki Yasuhiro、Misawa Hidemi、Ono Shiro、Horiguchi Kazuhide、Kawashima Koichiro
    • Journal Title

      Front. Immunol.

      Volume: 8 Pages: 1085-1085

    • DOI

      10.3389/fimmu.2017.01085

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09375, KAKENHI-PROJECT-17K10626, KAKENHI-PROJECT-15K07969, KAKENHI-PROJECT-15K07979, KAKENHI-PROJECT-16K15129
  • [Journal Article] Selective Expression of Osteopontin in ALS-resistant Motor Neurons is a Critical Determinant of Late Phase Neurodegeneration Mediated by Matrix Metalloproteinase-9.2016

    • Author(s)
      Morisaki Y, Niikura M, Watanabe M, Onishi K, Tanabe S, Moriwaki Y, Okuda T, Ohara S, Murayama S, Takao M, Uchida S, Yamanaka K, Misawa H.
    • Journal Title

      Sci Rep

      Volume: 6 Pages: 27354-27354

    • DOI

      10.1038/srep27354

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26293208, KAKENHI-PROJECT-15K21370, KAKENHI-PROJECT-16H06277
  • [Journal Article] Neuregulin 1 confers neuroprotection in SOD1-linked amyotrophic lateral sclerosis mice via restoration of C-boutons of spinal motor neurons2016

    • Author(s)
      Lasiene J, Komine O, Fujimori-Tonou N, Powers B, Endo F, Watanabe S, Shijie J, Ravits J, Horner P, Misawa H, Yamanaka K
    • Journal Title

      Acta Neuropathol. Commun.

      Volume: 4 Pages: 15-15

    • DOI

      10.1186/s40478-016-0286-7

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25860252, KAKENHI-PROJECT-26830046, KAKENHI-PLANNED-23111006, KAKENHI-PROJECT-25293020, KAKENHI-PROJECT-26293208
  • [Journal Article] Transcriptional regulation of SLURP-2, a psoriasis-associated gene, is under the control of IL-22 in the skin: a special reference to the nested gene Lynx1.2015

    • Author(s)
      Moriwaki Y, Takada K, Tsuji S, Kawashima K, Misawa H
    • Journal Title

      Int. Immunolpharmacol.

      Volume: 29 Pages: 71-5

    • DOI

      10.1016/j.intimp.2015.05.030

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K07969, KAKENHI-PROJECT-15K21370, KAKENHI-PROJECT-25293020
  • [Journal Article] SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70 chaperone system.2015

    • Author(s)
      Watanabe S, Ageta-Ishihara N, Nagatsu S, Takao K, Komine O, Endo F, Miyakawa T, Misawa H, Takahashi R, Kinoshita M, Yamanaka K.
    • Journal Title

      Mol Brain.

      Volume: 7 Pages: 2532-2532

    • DOI

      10.1186/s13041-014-0062-1

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-221S0003, KAKENHI-PLANNED-23111006, KAKENHI-PUBLICLY-25116514, KAKENHI-PUBLICLY-25116526, KAKENHI-PROJECT-25293020, KAKENHI-PROJECT-25350989, KAKENHI-PROJECT-25860252, KAKENHI-PUBLICLY-26115529, KAKENHI-PROJECT-26293208, KAKENHI-PROJECT-26440095, KAKENHI-PLANNED-23111002, KAKENHI-PROJECT-25242078
  • [Journal Article] Non-neuronal cholinergic system in regulation of immune function with a focus on α7 nAChRs.2015

    • Author(s)
      Kawashima K, Fujii T, Moriwaki Y, Misawa H, Horiguchi K
    • Journal Title

      Int. Immunopharmacol.

      Volume: 印刷中 Pages: 127-134

    • DOI

      10.1016/j.intimp.2015.04.015

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24590120, KAKENHI-PROJECT-15K07969, KAKENHI-PROJECT-25221205, KAKENHI-PROJECT-25460947, KAKENHI-PROJECT-25293020
  • [Journal Article] IL-22/STAT3-induced increases in SLURP1 expression within psoriatic lesions exerts antimicrobial effects against Staphylococcus aureus2015

    • Author(s)
      Moriwaki Y, Takada K, Nagasaki T, Kubo N, Ishii T, Kose K, Kageyama T, Tsuji S, Kawashima K, Misawa H
    • Journal Title

      PLoS One

      Volume: 該当なし

    • DOI

      10.1371/journal.pone.0140750

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K07969, KAKENHI-PROJECT-15K21370, KAKENHI-PROJECT-25293020
  • [Journal Article] SLURP-1, an endogenous alpha7 nicotinic acetylcholine receptor allosteric ligand, is expressed in CD205+ dendritic cells in human tonsils and potentiates lymphocytic cholinergic activity2014

    • Author(s)
      藤井 健志
    • Journal Title

      J Neuroimmunol

      Volume: 267 Pages: 4349-4349

    • DOI

      10.1016/j.jneuroim.2013.12.003

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590121, KAKENHI-PROJECT-24590120, KAKENHI-PROJECT-25221205
  • [Journal Article] Selective disruption of acetylcholine synthesis in a subsets of motor neurons: A new model of late-onset motor neuron disease2014

    • Author(s)
      Lecomte, M-J., Bertolus, C., Santamaria, J., Bauchet, A-L., Herbin, M., Saurini, F., Misawa, H., Maisonobe, T., Pradat, P-F. Nosten-Bertrand, M., Mallet, J. and Berrard S.
    • Journal Title

      Neurobiol Dis

      Volume: 65 Pages: 102-111

    • DOI

      10.1016/j.nbd.2014.01.014

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-23111006, KAKENHI-PROJECT-25293020
  • [Journal Article] Loss of TDP-43 causes age-dependent progressive motor neuron degeneration.2013

    • Author(s)
      Iguchi Y
    • Journal Title

      Brain.

      Volume: 136 Pages: 1371-1382

    • DOI

      10.1093/brain/awt029

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22390175, KAKENHI-PROJECT-22590965, KAKENHI-ORGANIZER-23111001, KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-23659452, KAKENHI-PROJECT-25293020, KAKENHI-PLANNED-22110005
  • [Journal Article] Effect of secreted lymphocyte antigen-6/urokinase-type plasminogen activator receptor-related peptide-1 (SLURP-1) on airway epithelial cells2013

    • Author(s)
      Narumoto O, Niikura Y, Ishii S, Morihara H, Okashiro S, Nakahari T, Nakano T, Matsumura H, Shimamoto C, Moriwaki Y, Misawa H, Yamashita N, Nagase T, Kawashima K, Yamashita N.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 438 Pages: 175-179

    • DOI

      10.1016/j.bbrc.2013.07.048

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23249045, KAKENHI-PROJECT-25293020, KAKENHI-PROJECT-25460660
  • [Journal Article] Osteopontin is an alpha motor neuron marker in the mo use spinal cord2012

    • Author(s)
      Misawa H., 他5名
    • Journal Title

      J. Neurosci. Res

      Volume: 90 Pages: 732-742

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390274
  • [Journal Article] Osteopontin is an alpha motor neuron marker in the mouse spinal cord.2012

    • Author(s)
      Misawa H., et al., 他5名
    • Journal Title

      Journal of Neuroscience Research

      Volume: 90 Pages: 732-742

    • DOI

      10.1002/jnr.22813

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390274, KAKENHI-PLANNED-23111006, KAKENHI-PROJECT-23790097
  • [Journal Article] Sustained subcutaneous infusion of nicotine enhances cholinergic vasodilation in the cerebral cortex induced by stimulation of the nucleus basalis of Meynert in rats.2011

    • Author(s)
      Uchida, S., Hotta, H., Misawa, H., 他
    • Journal Title

      Eur.J.Pharmacol. 654

      Pages: 238-240

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20500340
  • [Journal Article] Substrate-induced internalization of the high-affinity choline transporter2011

    • Author(s)
      Okuda T., Konishi A., Misawa H., H aga T.
    • Journal Title

      J. Neurosci

      Volume: 31 Pages: 14989-14997

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390274
  • [Journal Article] Down-regulation of secrete d lymphocyte antigen-6/urokinase-type pl asminogen activator-related peptide-1(SLURP-1), an endogenous allosteric & 7nic otinic acetylcholine receptor modulator, i n murine and human asthmatic conditio ns2010

    • Author(s)
      Narumoto O., 他5名, Misawa H., Ya mashita N., Nagase T., Kawashima K., Yamashita N
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 398 Pages: 713-718

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390274
  • [Journal Article] Induced loss of ADAR2 engenders slow death of motor neurons from Q/R site-unedited GluR2.2010

    • Author(s)
      Hideyama, T., Yamashita, T., Suzuki, T., Tsuji, S., Higuchi, M., Seeburg, P.H., Takahashi, R., Misawa, H., Kwak, S.
    • Journal Title

      J.Neurosci. 30

      Pages: 11917-11925

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20500340
  • [Journal Article] miRNA malfunction causes spinal motor neuron disease.2010

    • Author(s)
      Haramanti, S., Chapnik, E., Sztainbreg, H., Eilam-Altstadter, R., Zwang, R., Gershoni, N., McGlinn, E., Heiser, P.W., Wills, A-M., Wirguin, I., Rubin, L., Misawa, H., Tabin C.J., Brown Jr.R., Chen, A., Hornstein, E.
    • Journal Title

      Proc.Natl.Acad.Sci.USA 107

      Pages: 13111-13116

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20500340
  • [Journal Article] Induced loss of ADAR2 engenders slow death of motor neurons from Q/R site-unedited GluR2.2010

    • Author(s)
      Hideyama T, Yamashita T, Suzuki T, Tsuji S, Higuchi M, Seeburg PH, Takahashi R, Misawa H, Kwak S.
    • Journal Title

      J Neurosci. 30

      Pages: 11917-11925

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390244
  • [Journal Article] Acetylcholine synthesis and release in N IH3T3 cells coexpressing the high-affinit y choline transporter and choline acetylt ransferase2009

    • Author(s)
      Fujii T. Masai M., Misawa H., 他5名
    • Journal Title

      J. Neurosci. Res

      Volume: 87 Pages: 3024-3032

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390274
  • [Journal Article] Primary sensory neuronal expression of SLURP-1, an endogenous nicotinic acetylcholine receptor ligand.2009

    • Author(s)
      Moriwaki, Y., Watanabe, Y., Shinagawa, T., Kai, M., Miyazawa, M., Okuda, T., Kawashima, K., Yanbashi, A., Waguri, S., Misawa, H.
    • Journal Title

      Neurosci.Res. 64

      Pages: 403-412

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20500340
  • [Journal Article] Prim ary sensory neuronal expression of SLU RP-1, an endogenous nicotinic acetylchol ine receptor ligand2009

    • Author(s)
      Moriwaki Y., 他8名, Misawa H.
    • Journal Title

      Neurosci. Res

      Volume: 64 Pages: 403-412

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390274
  • [Journal Article] Expression of SLURP-1, an endogenous alpha7 nicotinic acetylcholine receptor allostreric ligand, in murine bronchial epithelial cells.2009

    • Author(s)
      Horiguchi, K., Horiguchi, S., Yamashita, N., Irie, K., Masuda, J., Takano-Ohmuro, H., Himi, T., Miyazawa, M., Moriwaki, Y., Okuda, T., Misawa, H., Ozaki, H., Kawashima, K.
    • Journal Title

      J.Neurosci.Res. 87

      Pages: 2740-2747

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20500340
  • [Journal Article] Expression of SL URP-1, an endogenous alpha7 nicotinic acetylcholine receptor allosteric ligand, i n murine bronchial epithelial cells2009

    • Author(s)
      Horiguchi K., 他9名, Misawa H., Oz aki H., Kawashima K.
    • Journal Title

      J. Neurosci. Res

      Volume: 87 Pages: 2740-2747

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390274
  • [Journal Article] Aberrant trafficking of the high-affinity choline transporter in AP-3-deficient mice.2008

    • Author(s)
      Misawa H., et al.
    • Journal Title

      Eur. J. Neurosci. 27

      Pages: 3109-3117

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20500340
  • [Journal Article] Role of GluR1 in activity-dependent motor system development.2008

    • Author(s)
      Zhang, L., Schessl, J., Werner, M., Bonnemann, C., Xiong, G., Mojsilovic-Petrovic, J., Zhou, W., Cohen, A., Seeburg, P., Misawa, H., Jayaram, A., Personius, K., Hollmann, M., Sprengel, R., Kalb, R.
    • Journal Title

      J.Neurosci. 28

      Pages: 9953-9968

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20500340
  • [Journal Article] Aberrant trafficking of the high-affinity choline transporter in AP-3-deficient mice2008

    • Author(s)
      Misawa, H., Fujigaya, H., Nishimura, T., Moriwaki, Y., Okuda, T., Kawashima, K., Nakata, K., Ruggiero, A.M., Blakely, R.D., Nakatsu, F., Ohno, H.
    • Journal Title

      Eur.J.Neurosci. 27

      Pages: 3109-3117

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20500340
  • [Journal Article] L347P PINK1 mutant that fails to bind to Hsp90/cdc37 chaperones is rapidlydegraded in a proteasome-dependant manner.2008

    • Author(s)
      Moriwaki Y, KimY J, Ido Y, Misawa H, Kawashima K, Endo S, Takahashi, R.z
    • Journal Title

      Neurosci. Res. 61

      Pages: 43-48

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390244
  • [Journal Article] Astrocytes as determinants of disease progression in inherited ALS.2008

    • Author(s)
      Yamanaka, K., Chun, S.J., Boillee, S., Fujimori-Tonou, N., Yamashita, H., Gutmann, D.H., Takahashi, R., Misawa, H., Cleveland, D.W.
    • Journal Title

      Nature Neurosci. 11

      Pages: 251-253

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20500340
  • [Journal Article] Cleveland DW Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis.2008

    • Author(s)
      Yamanaka K, Chun SJ, Boillee S, Fujimori-Tonou N, Yamashita H, Gutmann DH, Takahashi R, Misawa H
    • Journal Title

      Nat.Neurosci. 11

      Pages: 251-253

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390244
  • [Journal Article] Ultrastructural localization of high-affinity choline transporter in the rat neuromuscular junction : Enrichment on synaptic vesicles.2004

    • Author(s)
      Nakata, K., Okuda, T., Misawa, H.
    • Journal Title

      Synapse 53

      Pages: 53-56

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14580735
  • [Journal Article] VAChT-Cre.Fast and VAChT-Cre.Slow : Postnatal expression of Cre recombinase in somatomotor neurons with different onset.2003

    • Author(s)
      Misawa H., et al.
    • Journal Title

      genesis 37

      Pages: 44-50

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15300129
  • [Journal Article] VAChT-Cre.Fast and VAChT-Cre.Slow : Postnatal expression of Cre recombinase in somatomotor neurons with different onset.2003

    • Author(s)
      Misawa, H., et al.
    • Journal Title

      genesis 37

      Pages: 44-50

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15300129
  • [Journal Article] VAChT-Cre.Fast and VAChT-Cre.Slow : Postnatal Expression of Cre Recombinase in Somatomotor Neurons With Different Onset2003

    • Author(s)
      Misawa, H., Nakata, K., Toda, K., Matsuura, J., Oda, Y., Inoue, H., Tateno, M., Takahashi, R.
    • Journal Title

      genesis 37

      Pages: 44-50

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14580735
  • [Journal Article] The crucial role of caspase-9 in the disease progression of a transgenic ALS mouse model2003

    • Author(s)
      Inoue, H., Tsukita, K., Iwasato, T., Suzuki, Y., Tomioka, M., Tateno, M., Nagao, M., Kawata, A., Saido, T.C., Miura, M., Misawa, H., Itohara, S., Takahashi, R.
    • Journal Title

      EMBO J 22

      Pages: 6665-6674

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14580735
  • [Journal Article] Conditional knockout of Mn superoxide dismutase in postnatal motor neurons reveals resistance to mitochondrial generated superoxide radicals.

    • Author(s)
      Misawa, H., et al.
    • Journal Title

      Neurobiol.Dis. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15300129
  • [Journal Article] Conditional knockout of Mn superoxide dismutase in postnatal motor neurons reveals resistance to mitochondrial generated superoxide radicals.

    • Author(s)
      Misawa H., et al.
    • Journal Title

      Neurobiol. Dis. (in press)

    • Data Source
      KAKENHI-PROJECT-15300129
  • [Journal Article] Conditoional knockout of Mn superoxide dismutase in postnatal motor neurons reveals resistance to mitochondrial generated superoxide radicals.

    • Author(s)
      Misawa H., et al.
    • Journal Title

      Neurobiol. Dis. (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15300129
  • [Presentation] ALSモデルマウスにおけるアクアポリン4を介した脳内の老廃物排泄機構の異常.2022

    • Author(s)
      安達一貴, 廣瀬美嘉子, 麻野珠都, 阿部陽一郎,安井正人, 三澤日出巳.
    • Organizer
      第95回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-19K07128
  • [Presentation] ALSモデルマウスにおけるグリアリンパ系と老廃物排泄異常の解析.2021

    • Author(s)
      安達一貴, 廣瀬美嘉子, 麻野珠都, 三澤日出巳.
    • Organizer
      生体機能と創薬シンポジウム2021
    • Data Source
      KAKENHI-PROJECT-19K07128
  • [Presentation] SOD1-ALSモデルマウスにおけるグリアリンパ系の破綻と老廃物排泄遅延.2021

    • Author(s)
      廣瀬美嘉子, 麻野珠都, 松本さおり, 山中宏二, 阿部陽一郎, 安井正人, 徳田栄一, 古川良明, 三澤日出巳.
    • Organizer
      第94回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-19K07128
  • [Presentation] 抗中皮腫活性を示す二重特異性抗体の開発.2020

    • Author(s)
      金守悠希, 森脇康博, 三澤日出巳, 今井浩三, 辻祥太郎.
    • Organizer
      第40回日本分子腫瘍マーカー研究会
    • Data Source
      KAKENHI-PROJECT-19K07128
  • [Presentation] ALSの病態進行におけるグリアリンパ系の関与2020

    • Author(s)
      廣瀬美嘉子, 麻野珠都, 設楽周生, 阿部陽一郎, 安井正人, 徳田栄一, 古川良明, 三澤日出巳
    • Organizer
      第93回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-19K07128
  • [Presentation] アルファー7型ニコチン受容体に対する新たな内在性修飾因子Ly6Hの作用機構:GPIアンカーの必要性2019

    • Author(s)
      浅野慎介, 森脇康博, 渡邊みずほ, 久保那月, 加藤総夫, 三澤日出巳
    • Organizer
      第140回日本薬理学会関東部会
    • Data Source
      KAKENHI-PROJECT-19K07128
  • [Presentation] Postnatal selective elimination of slow-type motor neuons induces late-onset neuromuscular defects in mice: red muscle atrophy, posture abnormality and kinetic tremor2019

    • Author(s)
      Kamishima K, Koyama T, Ohgaki L, yamanaka K, Ihohara S, Ogihara N, Sawano S, Mizunoya W, Misawa H
    • Organizer
      Neuroscience 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07128
  • [Presentation] ニコチン性アセチルコリン受容体に対する内在性モジュレーターLy6Hの調節作用.2018

    • Author(s)
      浅野慎介, 森脇康博, 渡邉みずほ, 久保那月, 加藤総夫, 三澤日出巳.
    • Organizer
      第138回日本薬理学会関東部会
    • Data Source
      KAKENHI-PROJECT-16K15129
  • [Presentation] Alpha7 ニコチン性アセチルコリン受容体刺激による制御性T細胞の分化促進.2017

    • Author(s)
      祭田 絢子、間下 雅士、小森 眞紗代、松井 悠理子、小野 史郎、川島 紘一郎、奥山 洋美、森脇 康博、三澤 日出巳、藤井 健志.
    • Organizer
      第67回 日本薬学会近畿支部総
    • Data Source
      KAKENHI-PROJECT-15K07969
  • [Presentation] 内在性神経毒類似タンパク質Ly6Hによるニコチン受容体調節.2017

    • Author(s)
      渡邉みずほ, 森脇康博, 久保那月, 加藤総夫, 三澤日出巳.
    • Organizer
      第137回日本薬理学会関東部会
    • Data Source
      KAKENHI-PROJECT-16K15129
  • [Presentation] Role for α7 nicotinic acetylcholine receptors in naive T cell differentiation into regulatory T cell.2016

    • Author(s)
      Kawashima K, Mashimo M, Fujii T, Moriwaki Y, Misawa H, Ono S.
    • Organizer
      The 46th Annual Meeting, Society for Neuroscience.
    • Place of Presentation
      San Diego (USA)
    • Year and Date
      2016-11-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K15129
  • [Presentation] Neuregulin 1 confers neuroprotection in SOD1-linked ALS mice via restoration of C-boutons of spinal motor neurons.2016

    • Author(s)
      Komine O, Lasiene J, Fujimori-Tonou N, Powers B, Endo F, Watanabe S, Jin S, Ravits J, Horner P, Misawa H, Yamanaka K.
    • Organizer
      The 27th International Symposium on ALS/MND
    • Place of Presentation
      ダブリン
    • Year and Date
      2016-12-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293208
  • [Presentation] ALSにおける運動神経サブタイプ選択的脆弱性を規定するメカニズム2016

    • Author(s)
      森﨑祐太, 渡邉みずほ, 森脇康博, 山中宏二, 三澤日出巳
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜 (神奈川県・横浜市)
    • Year and Date
      2016-03-10
    • Data Source
      KAKENHI-PROJECT-25293020
  • [Presentation] Role for α7 nicotinic acetylcholine receptors in naive T cell differentiation into regulatory T cells.2016

    • Author(s)
      Kawashima K, Mashimo M, Fujii T, Moriwaki M, Misawa H, Ono S
    • Organizer
      Neuroscience 2016
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2016-11-11
    • Data Source
      KAKENHI-PROJECT-15K07969
  • [Presentation] 運動ニューロンサブタイプの選択的脆弱性におけるオステオポンチンとマトリックスメタロプロテアーゼ-9の役割2015

    • Author(s)
      森﨑祐太、坪田充司、森脇康博、山中宏二、三澤日出巳
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸コンベンションセンター (兵庫県・神戸市)
    • Year and Date
      2015-07-28
    • Data Source
      KAKENHI-PROJECT-25293020
  • [Presentation] CMT病1C型原因遺伝子SIMPLEの変異はトランスゴルジネットワークでの輸送異常を引き起こす2015

    • Author(s)
      大野 祐歩、森脇 康博、石井 智裕、高村 侑希、三澤 日出巳.
    • Organizer
      第88回日本薬理学会年会
    • Place of Presentation
      名古屋市
    • Year and Date
      2015-03-19
    • Data Source
      KAKENHI-PROJECT-25293020
  • [Presentation] 運動神経サブタイプの選択的脆弱性を規定するメカニズム2015

    • Author(s)
      三澤日出巳
    • Organizer
      千里ライフサイエンスセミナー
    • Place of Presentation
      千里ライフサイエンスセンター (大阪府・豊中市)
    • Year and Date
      2015-07-08
    • Invited
    • Data Source
      KAKENHI-PROJECT-25293020
  • [Presentation] 組換えアデノ随伴ウイルス、レンチウイルスの軸索内逆行輸送による成体マウス運動ニューロンへのALS関連遺伝子導入2015

    • Author(s)
      石井 智裕、秋山 けい子、河上 江美子、柳澤 比呂子、三五 一憲、岡戸 晴生、三輪 昭子、三宅 弘一、加藤 茂樹、小林 和人、三澤 日出巳、渡部 和彦.
    • Organizer
      第88回日本薬理学会年会
    • Place of Presentation
      名古屋市
    • Year and Date
      2015-03-20
    • Data Source
      KAKENHI-PROJECT-25293020
  • [Presentation] ALSモデルマウスにおける自然免疫TRIF経路の役割2015

    • Author(s)
      小峯 起、山下博史、藤森典子、森脇康博、三澤 日出巳、山中宏二
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-28
    • Data Source
      KAKENHI-PLANNED-23111006
  • [Presentation] Roles of osteopontin and matrix metalloproteinase-9 in the subtype-selective motor neuron vulnerability in ALS2015

    • Author(s)
      Morisaki Y, Tsubota A, Watanabe M, Moriwaki Y, Yamanaka K, Misawa H
    • Organizer
      The 45th Annual Meeting, Society for Neuroscience
    • Place of Presentation
      Chicago (USA)
    • Year and Date
      2015-10-18
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25293020
  • [Presentation] 運動ニューロンのサブタイプ選択的脆弱性におけるオステオポンチンとマトリックスメタロプロテアーゼ-9の役割2015

    • Author(s)
      森崎祐太、坪田充司、森脇康博、山中宏二、三澤日出巳
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-28
    • Data Source
      KAKENHI-PLANNED-23111006
  • [Presentation] オステオポンチンはマウス脊髄におけるアルファー運動ニューロンサブタイプの新規マーカーである2014

    • Author(s)
      森﨑 祐太、坪田 充司、森脇 康博、奥田 隆志、山中宏二、三澤 日出巳
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2014-09-11
    • Data Source
      KAKENHI-PLANNED-23111006
  • [Presentation] オステオポンチンはマウス脊髄におけるアルファー運動ニューロンサブタイプの新規マーカーである2014

    • Author(s)
      森﨑 祐太、坪田 充司、森脇 康博、奥田 隆志、山中宏二、三澤 日出巳.
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-09-11
    • Data Source
      KAKENHI-PROJECT-25293020
  • [Presentation] 筋萎縮性側索硬化症における浸潤免疫細胞の機能解明2014

    • Author(s)
      小峯 起、山下博史、藤森典子、森脇康博、三澤日出巳、山中宏二.
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-09-11
    • Data Source
      KAKENHI-PROJECT-25293020
  • [Presentation] ニコチン受容体の新たな内在性修飾蛋白質候補の同定と発現解析2014

    • Author(s)
      森脇 康博、久保 那月、杉野 太郎、三澤 日出巳.
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-09-11
    • Data Source
      KAKENHI-PROJECT-25293020
  • [Presentation] 筋萎縮性側索硬化症における運動ニューロン変性とオステオポンチンおよびマトリックスメタロプロテアーゼ-9の関連の検討2014

    • Author(s)
      森﨑祐太、坪田充司、森脇康博、山中宏二、三澤日出巳.
    • Organizer
      第131回日本薬理学会関東部会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-10-11
    • Data Source
      KAKENHI-PROJECT-25293020
  • [Presentation] SLURP-1, an endogenous alpha7 nAChR allosteric ligand, expression in human immune organs and function in regulation of lymphocytic cholinergic activity.2013

    • Author(s)
      1. Kawashima K, Fujii T, Horiguchi K, Moriwaki Y, Misawa H.
    • Organizer
      The 2nd Joint Meeting of the International Society for Autonomic Neuroscience and the European Federation of Autonomic Societies
    • Place of Presentation
      Giessen, Germany
    • Data Source
      KAKENHI-PROJECT-24590120
  • [Presentation] The establishment and analysis of 26S proteasome conditional knockout mice for the mechanisms of neurodegenerative diseases.2010

    • Author(s)
      Tashiro Y, Inoue H, Yamazaki M, Abe M, Ito H, Misawa H, Sakimura K, Takahashi R
    • Organizer
      BMB2010
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-08
    • Data Source
      KAKENHI-PROJECT-20390244
  • [Presentation] 神経変性疾患モデル作製のための26Sプロテアソームコンディショナルノックアウトマウスの確立と解析2010

    • Author(s)
      田代善崇、井上治久、山崎真弥、阿部学、伊東秀文、三澤日出巳、崎村建司、高橋良輔
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-03
    • Data Source
      KAKENHI-PROJECT-20390244
  • [Presentation] ニコチン性アセチルコリン受容体の内在性アロステリツクリガンドSLURP-1の一次知覚神経での発現2008

    • Author(s)
      三澤日出巳, 他4名
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      横浜市
    • Year and Date
      2008-07-10
    • Data Source
      KAKENHI-PROJECT-20500340
  • [Presentation] ニコチン性アセチルコリン受容体内在性アロステリックリガンドSLURP1の一次知覚神経での発現2008

    • Author(s)
      三澤日出巳, 他
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-10
    • Data Source
      KAKENHI-PROJECT-20500340
  • [Presentation] Motor neuron-derived osteopontin is an aggravation factor in the disease onset of ALS mice

    • Author(s)
      Niikura M, Tanabe S, Moriwaki Y, Yamanaka K, Misawa H.
    • Organizer
      Neuroscience 2013
    • Place of Presentation
      San Diego, California
    • Data Source
      KAKENHI-PROJECT-25293020
  • [Presentation] 筋萎縮性側索硬化症モデルマウスにおけるアクアポリン4の発現変動

    • Author(s)
      岩崎愛里, 中田俊輔, 森脇康博, 奥田隆志, 山中宏二, 阿部陽一郎, 安井正人, 三澤日出巳.
    • Organizer
      日本薬学会 第134年会
    • Place of Presentation
      熊本市
    • Data Source
      KAKENHI-PROJECT-25293020
  • [Presentation] 自然免疫TRIF経路遮断によってALS疾患の進行が顕著に加速する

    • Author(s)
      小峯起, 藤森典子, 山下博史, 森脇康博, 三澤日出巳, 山中宏二.
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都市
    • Data Source
      KAKENHI-PROJECT-25293020
  • [Presentation] 新たなニコチン受容体の内在性修飾蛋白質LyPD2の同定と発現解析

    • Author(s)
      森脇康博、篠塚理恵、西田舞香、石井智裕、中村太洋、稲葉翔、三澤日出巳.
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都市
    • Data Source
      KAKENHI-PROJECT-25293020
  • [Presentation] Osteopontin/CD44 pathway in a mouse model of amyotrophic lateral sclerosis

    • Author(s)
      大西晃輔, 森脇康博, 新倉麻己子, 森崎祐太, 山中宏二, 三澤日出巳.
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台市
    • Data Source
      KAKENHI-PROJECT-25293020
  • 1.  TAKAHASHI Ryosuke (90216771)
    # of Collaborated Projects: 13 results
    # of Collaborated Products: 7 results
  • 2.  MORIWAKI Yasuhiro (00392150)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 13 results
  • 3.  YAMANAKA Koji (80446533)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 19 results
  • 4.  YAMASHITA Hirofumi (60402913)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 2 results
  • 5.  KAWAMATA Jun (60360814)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  INOUE Haruhisa (70332327)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 7.  KOMINE Okiru (00456211)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 8.  WATANABE Seiji (70633577)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
  • 9.  ENDO Fumito (10713307)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 10.  KAWASHIMA Koichiro (70095008)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 9 results
  • 11.  FUJII Takeshi (80255380)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
  • 12.  HORIGUCHI Kazuhide (20377451)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 5 results
  • 13.  出口 武夫 (20073059)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 14.  松浦 純子 (20280779)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 15.  糸原 重美 (60252524)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 16.  OKUDA Takashi (00322040)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 17.  KUROKAWA Yoichi (40326088)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  WATANABE Shoji (80462745)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  OYANAGI Kiyomitsu (00134958)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  KANDA Naotoshi (40075429)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  WATABE Kazuhiko (30240477)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  Suzumura Akio (50196896)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  Takeuchi Hideyuki (30362213)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  高橋 英機 (40446521)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 25.  内匠 透 (00222092)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  間下 雅士 (30738886)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 27.  TSUJI Shoutaro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 28.  KATSUNO Masahisa
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 29.  TAKAO Keizo
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 30.  AGETA Natsumi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 31.  HORIGUCHI Satomi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 32.  YASUI Masato
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 33.  ABE Manabu
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 34.  HATTORI Satoko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 35.  TANAKA Tetsu
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 36.  Niikura Yuichi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 37.  古川 良明
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 38.  加藤 総夫
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 39.  祖父江 元
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 40.  秋山 修志
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 41.  堀 正敏
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 42.  森 満
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 43.  高尾 昌樹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 44.  渡辺 能行
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 45.  村山 繁雄
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 46.  渡辺 俊樹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 47.  宮川 剛
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 48.  阿部 修
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 49.  渡辺 雅彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 50.  石原 健
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 51.  高尾 英正
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 52.  伊佐 正
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 53.  饗場 篤
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 54.  高橋 淑子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 55.  木下 専
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 56.  山中 章弘
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 57.  橋本 唯史
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 58.  田中 謙二
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 59.  井本 正哉
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 60.  吉田 進昭
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 61.  吉田 稔
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 62.  徳田 栄一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 63.  長瀬 隆英
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 64.  山下 直美
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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