HASHIMOTO Nobuo 橋本信夫

… Alternative Names

HASHIMOTO M. D. Nobuo 橋本信夫

HASHIMOTO NOBUO 橋本信夫

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Researcher Number	40135570
Other IDs
Affiliation (based on the past Project Information) *help	2010: 京都大学, 大学院・医学研究科, 教授 2010: 国立循環器病研究センター, 理事長 2009: 国立循環器病センター, 総長 2008: National Cardiovascular Center Research Institute, 国立循環器病センター研究所, 総長 2008: National Cardiovascular Center Research Institute, 総長 … More 2000 – 2008: Kyoto University, Neurosurgery, Professor, 医学研究科, 教授 2006: 京都大学, 医学系研究科, 教授 1999: 京都大学, 大学院・医学研究科, 教授 1998: 京都大学, 医学研究科, 教授 1990 – 1992: 京都大学, 医学部, 講師 1987 – 1988: 京都大学, 医学部, 講師 Less
Review Section/Research Field	Principal Investigator Cerebral neurosurgery / Cerebral neurosurgery Except Principal Investigator Cerebral neurosurgery / Cerebral neurosurgery / Biological Sciences / Hygiene / Hygiene
Keywords	Principal Investigator 脳動脈瘤 / MMP / 実験的動脈瘤 / TIMP / 内皮細胞 / 増殖因子 / cerebral aneurysm / endothelium / Cerebral ischemia / Thioredoxin … More / ラット / iNOS / 動物モデル / IL-1β / TNF-α / 成因 / Rbo / mDia1 / 神経膠芽腫 / 接着班 / SDF-1α / 浸潤 / Rho / mDial / 脳血管障害学(脳動脈瘤クモ膜下出血炎症) / 脳神経疾患 / 脳血管障害 / クモ膜下出血 / NF-kB / 炎症 / 流体力学 / 実験的脳動脈瘤 / 脈動脈瘤 / 実験的脈動脈瘤 / レオロジ- / rheology / growth factor / experimental cerebral aneurysm / 脳虚血 / レドックス / チオレドキシン / 脳梗塞 / 神経細胞 / redox / cerebral infarction / redox regulation / oxidative stress / cerebral ischemia / thioredoxin / rat / mouse / ジャービル / Redox / Cerebral infection / neuron / endothelin / 遺伝子 / 血行力学的ストレス / 高血圧 / マウス / hemodynamic stress / cerebral aneurysmal / gene / アポトーシス / 連鎖解析 / animal model / apoptosis / linkage analysis / XIII因子 / 内膜肥厚 / 平滑筋細胞 / 頸動脈結紮 / Factor XIII / Experimental aneurysm / Cerebral aneurysm / Intimal proliferation … More Except Principal Investigator 脳動脈瘤 / MAPK / 遺伝子 / 脳虚血 / 連鎖解析 / ischemic tolerance / 相関研究 / 虚血耐性 / Cerebral ischemia / 脳動静脈奇形 / 家族性 / 内皮前駆細胞 / 血管内皮前駆細胞 / くも膜下出血 / 家系 / ApoE / 遺伝子発現 / 全ゲノム解析 / 遺伝的感受性 / 17番染色体 / 家系に基づく調査 / ラット / ES細胞 / 下垂体 / Hes1 / Hes5 / 発生 / マウス / 中葉 / 前葉 / 後葉 / ジャービル / 遅発性神経細胞死 / gerbil / Ischemic tolerance / STAT / cerebral ischemia / 骨髄細胞 / 頸動脈ステント / バルーン損傷モデル / 頚動脈ステント / 骨髄 / 能動脈瘤 / 治療 / 再生 / ゲノム / 脳・神経 / 遺伝学 / 社会医学 / もやもや病 / 遺伝疫学 / 感受性遺伝子 / 候補領域 / 遺伝解析 / 神経誘導 / ドーパミン産生神経 / hes1 / hes5 / 遺伝子発現プロファイリング / 予後予測 / 神経膠腫 / ATAC-PCR / Real-time PCR / RNA / 予後判定 / 悪性神経膠腫 / PCR / プロファイリング / PCRアレイ / 個別化療法 / 脳神経外科医 / 適正配置 / 脳卒中 / 実態調査 / 脳卒中専門医 / 実験脳外科学 / 神経分化 / 細胞移植 / 炎症 / 前駆細胞 / Hesr1 / C-Jun NH_2-terminal kinase / p38 mitogen-activated protein kinase / Extracellular signal-regulated kinase / transient global ischemia / hippo campus / Delayed neuronal death / 海馬 / 動物モデル / 神経細胞 / hippocampus / delaged neuronal death / 遺伝子解析 / 多発家族 / MRI / SNPs / リスク要因 / Intracranial aneurysm / Genome-wide analysis / Genetic susceptibility / Linkage analysis / Association study / Chromosome 17 / Family-based study / 脳梗塞 / MARK / 神経細胞死 / 脳神経疾患 Less

Optimization of the host brain environment for the cell replacement therapy using ES cells
- Principal Investigator
  
  TAKAHASHI Jun
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kyoto University
Research on the differentiation mechanism of pituitary stem cells and its application to regeneration medicine
- Principal Investigator
  
  HOJO Masato
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kyoto University
Clarification of mechanisms and role of inflammation cascade during cerebral aneurysm formation and developmentPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Nobuo
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  National Cardiovascular Center Research Institute
  Kyoto University
Using gene expression profiling to identify a prognostic molecular spectrum in gliomas
- Principal Investigator
  
  TAKAHASHI Jun
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Tazuke Kofukai Medical Research Institute
  Kyoto University
日本の脳神経外科医適正配置に向けての企画調査
- Principal Investigator
  
  嘉山孝正
- Project Period (FY)
  2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Yamagata University
The genetic epidemiology of cerebrovascular disease with high risk genetic factors to establish the secondary prevention program targeting high risk subjects
- Principal Investigator
  
  KOIZUMI Akio
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Hygiene
- Research Institution
  Kyoto University
髄膜とPA6との比較検討によるドーパミン産生神経誘導能の解明
- Principal Investigator
  
  TAKAHASHI Jun
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kyoto University
下垂体前駆細胞の分化運命決定機構におけるnotch-hes経路の関与に関する研究
- Principal Investigator
  
  HOJO Masato
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kyoto University
Involvement of MAPK cascade in ischemic neuronal damage
- Principal Investigator
  
  NOZAKI Kazuhiko
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kyoto University
The molecular mechanisms of initiation, progression, rupture of cerebral aneurysms and development of a preventive treatment for itPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Nobuo
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kyoto University
脳動脈瘤多発家系を用いた責任遺伝子の解明
- Principal Investigator
  
  小泉昭夫
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
悪性神経膠芽腫におけるRho情報伝達系による浸潤機構の解析と創薬の探索Principal Investigator
- Principal Investigator
  
  橋本信夫
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kyoto University
血管内皮前駆細胞を用いた脳動脈瘤に対する血管壁再生治療の開発
- Principal Investigator
  
  菊田健一郎
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kyoto University
脳動脈瘤多発家系を用いた責任遺伝子の解明
- Principal Investigator
  
  KOIZUMI Akio
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
実験的脳動脈瘤における遺伝子発現
- Principal Investigator
  
  野崎和彦
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kyoto University
Basic research for cerebral ischemia therapy based on ischemic tolerance
- Principal Investigator
  
  NOZAKI Kazuhiko
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  KYOTO UNIVERSITY
Genetic dissection of familial intracranial aneurysms by family-based approach
- Principal Investigator
  
  KOIZUMI Akio
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Hygiene
- Research Institution
  Kyoto University
脳血管奇形における遺伝子発現および遺伝子多型
- Principal Investigator
  
  NOZAKI Kazuhiko
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kyoto University
血管内皮増殖抑制遺伝子導入型再狭窄予防ステントの開発
- Principal Investigator
  
  定藤章代
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kyoto University
Molecular mechanisms of cerebral aneurysmal formationPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Nobuo
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kyoto University
Molecular mechanisms of ischemic tolerance in brains
- Principal Investigator
  
  NOZAKI Kazuhiko
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  KYOTO UNIVERSITY
Involvement of MAPK cascades in ischemic tolerance in neurons
- Principal Investigator
  
  NOZAKI Kazuhiko
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  KYOTO UNIVERSITY
Involvement of redox mechanisms in ischemic neuronal deathPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Nobuo
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  KYOTO UNIVERSITY
脳動脈瘤の発生、増大、破裂およびその防御機構Principal Investigator
- Principal Investigator
  
  橋本信夫
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kyoto University
Mechanism of origin, growth, rupture and defence of cerebral aneurysmsPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO M. D. Nobuo
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kyoto Universiyt
Mechanisms of the origin, growth and rupture of cerebral aneurysmsPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO NOBUO
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kyoto University

All 2011 2010 2009 2008 2007 2006 2004 2003 2002 2001 2000 Other

All Journal Article Presentation Patent

[Journal Article] Single and local blockade of IL-6 signaling promotes neuronal differentiation of transplanted ES cell-derived neural precursor cells.2011
- Author(s)
  Gomi M, Aoki T, Takagi Y, Nishimura M, Ohsugi Y, Mihara M, Nozaki K, Hashimoto N, Miyamoto S, Takahashi J.
- Journal Title
  
  J Neurosci Res (in press)
- Data Source
  KAKENHI-PROJECT-20390383
[Journal Article] Single and local blockade of IL-6 signaling promotes neuronal differentiation of transplanted ES cell-derived neural precursor cells.2011
- Author(s)
  Gomi M, Aoki T, Takagi Y, Nishimura M, Ohsugi Y, Mihara M, Nozaki K, Hashimoto N, Miyamoto S, Takahashi J.
- Journal Title
  
  J Neurosci Res
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390383
[Journal Article] Matrigel supports survival and neuronal differentiation of grafted embryonic stem cell-derived neural precursor cells2010
- Author(s)
  Uemura M, Refaat M.M, Shinoyama M, Hayashi H, Hashimoto N, Takahashi J.
- Journal Title
  
  J Neurosci Res 88
  
  Pages: 542-551
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390383
[Journal Article] A rare Asian founder polymorphism in Raptor may explain the high prevalence of moyamoya disease in East Asian and low prevalence in Caucasian. Environ.2009
- Author(s)
  Liu W, Hashikata H, Inoue K, Matsuura N, Mineharu Y, Kobayashi H, Kikuta K, Takagi Y, Hitomi T, Krischek B, Zou L, Fang F, Herzig R, Kim J, Kang H, Oh C, Tregouet D, Hashimoto N, Koizumi A
- Journal Title
  
  Health Prev Med. 15(2)
  
  Pages: 94-104
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109007
[Journal Article] Impact of monocyte chemoattractant protein-1 deficiency on cerebral aneurysm formation2009
- Author(s)
  T.Aoki, H.Kataoka, R Ishibashi, K.Nozaki, N.Hashimoto
- Journal Title
  
  Stroke 40
  
  Pages: 942-951
- Data Source
  KAKENHI-PROJECT-19390377
[Journal Article] もやもや病(ウイリス動脈輪閉塞症)診断・治療ガイドライン2009
- Author(s)
  橋本信夫, 小泉昭夫, 他
- Journal Title
  
  脳卒中の外科 37巻
  
  Pages: 321-337
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109007
[Journal Article] Pitavastatin suppresses the formation and progression of cerebral aneurysms through the inhibition of nuclear factor kappa B pathway2009
- Author(s)
  T.Aoki,H.Kataoka,R.Ishibashi,H.Nakagami ,K.Nozaki,R.Morishita,N.Hashimoto
- Journal Title
  
  Neurosurgery 64
  
  Pages: 357-366
- Data Source
  KAKENHI-PROJECT-19390377
[Journal Article] もやもや病(ウイリス動脈輪閉塞症)診断2009
- Author(s)
  橋本信夫, 冨永悌二, 宮本享, 永田泉, 寶金清博, 鈴木則宏, 小泉昭夫, 野川茂, 中川原譲二, 北川一夫, 黒田敏, 菊田健一郎, 藤村幹, 高橋淳, 林健太郎, 大木宏一, 星野晴彦, 高木康志
- Journal Title
  
  治療ガイドライン・脳卒中の外科 37巻5号
  
  Pages: 321-37
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109007
[Journal Article] Using gene expression profiling to identify a prognostic molecular spectrum in gliomas2009
- Author(s)
  Shirahata M, Oba S, Iwao-Koizumi K, Saito S, Ueno N, Oda M, Hashimoto N, Ishii S, Takahashi J A, Kato K.
- Journal Title
  
  Cancer Sci. 100
  
  Pages: 165-72
- NAID
  10025141815
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390398
[Journal Article] Using gene expression profiling to identify a prognostic molecular spectrum in gliomas2009
- Author(s)
  Shirahata M, Oba S, Iwao-Koizumi K, Saito S, Ueno N, Oda M, Hashimoto N, Ishii S, Takahashi JA, Kato K
- Journal Title
  
  Cancer Sci 100(1)
  
  Pages: 165-72
- NAID
  10025141815
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390398
[Journal Article] Impact of monocyte chemoattractant protein-1 deficiency on cerebral aneurysm formation2009
- Author(s)
  T. Aoki, H. Kataoka, R Ishibashi, K. Nozaki, N. Hashimoto
- Journal Title
  
  Stroke 40
  
  Pages: 942-951
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390377
[Journal Article] Pitavastatin suppresses the formation and progression of cerebral aneurysms through the in2009
- Author(s)
  T. Aoki, H. Kataoka, R Ishibashi, H. Nakagami, K. Nozaki, R. Morishita, N. Hashimoto
- Journal Title
  
  Neurosurgery 64
  
  Pages: 357-366
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390377
[Journal Article] Autosomal dominant moyamoya disease maps to chromosome 17q25. 32008
- Author(s)
  Mineharu Y, Liu W, Inoue K, Matsuura N, Inoue S, Takenaka K, Ikeda H, Houkin K, Takagi Y, Kikuta K, Nozaki K, Hashimoto N, Koizumi A
- Journal Title
  
  NEUROLOGY 70
  
  Pages: 2357-2363
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109007
[Journal Article] Locus-wide association study confirms chromosome 14q23 as a susceptibility locus for intracranial aneurysm.2008
- Author(s)
  Mineharu Y, Inoue K, Inoue S, Kikuchi K, Ohishi H, Nozaki K, Hashimoto N, Koizumi A
- Journal Title
  
  Journal of Human Genetics 53(4)
  
  Pages: 325-332
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109007
[Journal Article] Inhibition of the Rho/ROCK pathway reduces apoptosis during transplantation of embryonic stem cell-derived neural precursors.2008
- Author(s)
  Koyanagi M, Takahashi J, Arakawa Y, Doi D, Fukuda H, Hayashi. H, Narumiya S, Hashimoto N.
- Journal Title
  
  J Neurosci Res 86(2)
  
  Pages: 270-280
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390383
[Journal Article] Meningeal cells induce dopaminergic neurons from embryonic stem cells.2008
- Author(s)
  Hayashi H, Morizane A, Koyanagi M, Ono Y, Sasai Y, Hashimoto N, Takahashi J.
- Journal Title
  
  Eur J Neurosci 27
  
  Pages: 261-268
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390383
[Journal Article] Long term outcomes in patients with intracranial germinomas : a single institution experience of irradiation with or without chemotherapy2008
- Author(s)
  Kawabata Y, Takahashi JA, Arakawa Y, Shirahata M, Hashimoto N.
- Journal Title
  
  J Neurooncol 88
  
  Pages: 161-167
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390398
[Journal Article] Simvastatin suppresses the progression of experimentally induced cerebral aneurysms in rat2008
- Author(s)
  T. Aoki, H. Kataoka, R Ishibashi, K. Nozaki, N. Hashimoto
- Journal Title
  
  Stroke 39
  
  Pages: 1276-1285
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390377
[Journal Article] 専門医に求められる最新の知識脳血管障害家族性もやもや病2008
- Author(s)
  峰晴陽平, 菊田健一郎, 高木康志, 野崎和彦, 橋本信夫, 小泉昭夫
- Journal Title
  
  脳神経外科速報 18巻7号
  
  Pages: 868-87
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109007
[Journal Article] Autosomal dominant moyamoya disease maps to chromosome17q25.3.2008
- Author(s)
  Mineharu Y, Liu W, Inoue K, Matsuura N, Inoue S. Takenaka K, Ikeda H, Houkin K, Takagi Y, Kikuta K, Nozaki K, Hashimoto N, Koizumi A.
- Journal Title
  
  Neurology 70
  
  Pages: 235-232
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109007
[Journal Article] もやもや病の遺伝要因の探索の現状2008
- Author(s)
  箸方宏州, 劉万洋, 峰晴陽平, 井上佳代子, 竹中勝信, 池田秀敏, 寶金清博, 黒田敏, 菊池顕次, 木村充, 瀧琢有, 園部眞, 伴貞彦, 野垣秀和, 半田明, 菊田健一郎, 高木康志, 野崎和彦, 橋本信夫, 小泉昭夫
- Journal Title
  
  BRAIN and NERVE:神経研究の進歩 60巻11号
  
  Pages: 1261-1269
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109007
[Journal Article] Nifedipine inhibits the progression of an experimentally induced cerebral aneurysm in rats with associated down-regulation of NF-kappaB transcriptional activity2008
- Author(s)
  T.Aoki, H.Kataoka, R Ishibashi, K.Nozaki, N.Hashimoto
- Journal Title
  
  Curr Neurovasc Res 5
  
  Pages: 37-45
- Data Source
  KAKENHI-PROJECT-19390377
[Journal Article] Immune or inflammatory response by the host brain suppresses neuronal differentiation of transplanted ES cell-derived neural precursor cells.2008
- Author(s)
  Ideguchi M, Shinoyama M, Gomi M, Hayashi H, Hashimoto N, Takahashi J.
- Journal Title
  
  J Neurosci Res 86(9)
  
  Pages: 1936-1943
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390383
[Journal Article] Simvastatin suppresses the progression of experimentally induced cerebral aneurysms in rats2008
- Author(s)
  T.Aoki, H.Kataoka, R Ishibashi, K.Nozaki, N.Hashimoto
- Journal Title
  
  Stroke 39
  
  Pages: 1276-1285
- Data Source
  KAKENHI-PROJECT-19390377
[Journal Article] Autosomal dominant moyamoya disease maps to chromosome 17q25.32008
- Author(s)
  Mineharu Y, Liu W, Inoue K, Matsura N, Inoue S, Takenaka K, Ikeda H, Houkin K, Takagi Y, Kikuta K, Nozaki K, Hashimoto N, Koizumi A.
- Journal Title
  
  Neurology (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109007
[Journal Article] Model-Based Linkage Analyses Confirm Chromosome 19q13.3 as a Susceptibility Locus for Intracranial Aneurysm2007
- Author(s)
  Mineharu Y, Inoue K, Inoue S, Yamada S, Nozaki K, Hashimoto N, Koizumi A.
- Journal Title
  
  Stroke. 38
  
  Pages: 1174-1178
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109007
[Journal Article] Locus-wide association study confirms chromosome 14q23 as a susceptibility locus for intracranial aneurysm2007
- Author(s)
  Mineharu Y, Inoue K, Inoue S, Kikuchi K, Ohishi H, Nozaki K, Hashimoto N, Koizumi A.
- Journal Title
  
  Journal of Human Genetics 53
  
  Pages: 325-332
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109007
[Journal Article] NF-kappa B is a key mediator of cerebral aneurysm formation2007
- Author(s)
  T.Aoki, H.Kataoka, R Ishibashi, K.Nozaki, N.Hashimoto
- Journal Title
  
  Circulation 116
  
  Pages: 2830-2840
- Data Source
  KAKENHI-PROJECT-19390377
[Journal Article] Model-Based Linkage Analyses Confirm Chromosome 19q13. 3 as a Susceptibility Locus for Intracranial Aneurysm.2007
- Author(s)
  Mineharu Y, Inoue K, Inoue S, Yamada S, Nozaki K, Hashimoto N, Koizumi A
- Journal Title
  
  Stroke 38
  
  Pages: 1174-1178
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109007
[Journal Article] Gene expression-based molecular diagnostic system for malignant gliomas is superior to histological diagnosis2007
- Author(s)
  Shirahata M, Iwao-Koizumi K, Saito S, Ueno N, Oda M, Hashimoto N, Takahashi JA, Kato K
- Journal Title
  
  Clin Cancer Res 13(24)
  
  Pages: 7341-56
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390398
[Journal Article] Inheritance pattern of familial moyamoya disease: autosomal dominant mode and genomic imprinting.2007
- Author(s)
  Mineharu Y, Takenaka K, Yamakawa, Inoue K, Kikuta K, Takagi Y, Nozaki K, Hashimoto N, Koizumi A.
- Journal Title
  
  J Neurol Neurosurg Psychiatr 77
  
  Pages: 1025-1029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109007
[Journal Article] Model-Based Linkage Analyses Confirm Chromosome 19q13.3 as a Susceptibility Locus for Intracranial Aneurysm2007
- Author(s)
  Mineharu Y., Inoue K., Inoue S., Yamada S., Nozaki K., Hashimoto N., Koizumi A.
- Journal Title
  
  Stroke (in press)
- Data Source
  KAKENHI-PROJECT-17109007
[Journal Article] Primate embryonic stem cell-derived neuronal progenitors transplanted into ischemic brain.2006
- Author(s)
  Hayashi J, Takagi Y, Nishimura M, Fijimoto M, Takahashi J, Hashimoto N, Nozaki K.
- Journal Title
  
  J CBFMetab 26
  
  Pages: 906-914
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390398
[Journal Article] Association Analysis of Common Variants of ELN, NOS2A, APOE, and ACE2 to Intracranial Aneurysm.2006
- Author(s)
  Mineharu Y, Inoue K, Inoue S, Yamada S, Nozaki K, Takenaka K, Hashimoto N, Koizumi A
- Journal Title
  
  Stroke 37
  
  Pages: 1189-1194
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109007
[Journal Article] Search on Chromosome 17 Centromere Reveals TNFRSF13B as a Susceptibility Gene for Intracranial Aneurysm.2006
- Author(s)
  Inoue K, Mineharu Y, Inoue S, Yamada S, Matsuda F, Nozaki K, Takenaka K, Hashimoto N, Koizumi A
- Journal Title
  
  A Preliminary Study. Circulation 113(13)
  
  Pages: 2002-2010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109007
[Journal Article] Association Analysis of Common Variants of ELN, NOS2A, APOE, and ACE2 to Intracranial Aneurysm2006
- Author(s)
  Mineharu Y., Inoue K., Inoue S., Yamada S., Nozaki K., Takenaka K., Hashimoto N., Koizumi A.
- Journal Title
  
  Stroke 37
  
  Pages: 1189-1194
- Data Source
  KAKENHI-PROJECT-17109007
[Journal Article] Inheritance pattern of familial moyamoya disease : autosomal dominant mode and genomic imprinting2006
- Author(s)
  Mineharu Y., Takenaka K., Yamakawa H., Inoue K., Ikeda H., Kikuta K., Takagi Y., Nozaki K., Hashimoto N., Koizumi A.
- Journal Title
  
  J Neurol Neurosurg Psychiatry 77
  
  Pages: 1025-1029
- Data Source
  KAKENHI-PROJECT-17109007
[Journal Article] Search on Chromosome 17 Centromere Reveals TNFRSF13B as a Susceptibility Gene for Intracranial Aneurysm. A Preliminary Study2006
- Author(s)
  Inoue K., Mineharu Y., Inoue S., Yamada S., Matsuda F., Nozaki K., Takenaka K., Hashimoto N., Koizumi A.
- Journal Title
  
  Circulation 113
  
  Pages: 2002-2010
- Data Source
  KAKENHI-PROJECT-17109007
[Journal Article] Administration of ex vivo-expanded bone marrow-derived endothelialprogenitor cells attenuates focal cerebral ischemia-reperfusion injury in rats.2006
- Author(s)
  Ohta T, Kikuta K, Imamura H, Takagi Y, Nishimura M, Arakawa Y, Hashimoto N, Nozaki K.
- Journal Title
  
  Neurosurgery 59
  
  Pages: 679-86
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390398
[Journal Article] Proliferarive activity through extracellular signal-regulated kinase of smooth muscle cells in the vascular walls of cerebral arteriovenous malformations.2006
- Author(s)
  Takagi Y, Kikuta K, Sadamasa N, Nozaki K, HashimotoN.
- Journal Title
  
  Neurosurgy 58
  
  Pages: 740-748
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390398
[Journal Article] Administration of ex vivo-expanded bone marrow-derived endothelial progenitor cells attenuates focal cerebral ischemia-reperfusion injury in rats.2006
- Author(s)
  Ohta T, Kikuta K, Imamura H, Takagi Y, Nishimura M, Arakawa Y, Hashimoto N, Nozaki K
- Journal Title
  
  Neurosurgery 59
  
  Pages: 679-686
- Data Source
  KAKENHI-PROJECT-16659387
[Journal Article] Inheritance pattern of familial moyamoya disease: autosomal dominant mode and genomic imprinting.2006
- Author(s)
  Mineharu Y, Takenaka K, Yamakawa H, Inoue K, Ikeda H, Kikuta K, Takagi Y, Nozaki K, Hashimoto N, Koizumi A
- Journal Title
  
  J Neurol Neurosurg Psychiatry 77
  
  Pages: 1025-1029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109007
[Journal Article] A genome-wide scan for Japanese familial intracranial aneurysms2004
- Author(s)
  Yamada S, Utsunomiya M, Inoue K, Inoue S, Nozaki K, Takenaka K, Hashimoto N, Koizumi A.
- Journal Title
  
  linkage to several chromosomal regions. Circulation 110(24)
  
  Pages: 3727-3733
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109007
[Journal Article] Activation of p38 kinase in the gerbil hippocampus showing ischemic tolerance.2003
- Author(s)
  Nishimura M, Sugino T, Nozaki K, Takagi Y, Hashimoto N, Moriguchi T, Nishida E.
- Journal Title
  
  J CBFMetab 23
  
  Pages: 1052-1059
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390398
[Journal Article] Control of axon elongation via an SDF-la/Rho/mDia pathway in cultured cerebellar granule neurons.2003
- Author(s)
  Arakawa Y, Bito H, Furuyashiki T, Kimura K, Nozaki K, Hashimoto N, Narumiya S.
- Journal Title
  
  J Cell Biol 161
  
  Pages: 381-391
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390398
[Journal Article] Hypoxia-ischemia induces thioredoxin expression and nitrotyrosine formation in new-born rat brain.2002
- Author(s)
  Hattori I, Takagi Y, Nozaki K, Kondo N, Bai J, Nakamura H, Hashimoto N, Yodoi J.
- Journal Title
  
  Redox Rep 7
  
  Pages: 256-9
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390398
[Journal Article] Mitogen-activated protein kinases and cerebral ischemia.2001
- Author(s)
  Nozaki K, Nishimura M, Hashimoto N.
- Journal Title
  
  Mol Neurobiol 23
  
  Pages: 1-19
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390398
[Journal Article] Activation of mitogen-activated protein kinases after transient forebrain ischemia in gerbil hippocampus.2000
- Author(s)
  Sugino T, Nozaki K, Takagi Y, Hattori I, Hashimoto N, Moriguchi T, Nishida E.
- Journal Title
  
  J Neurosci 20
  
  Pages: 4506-14
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390398
[Journal Article] Phosphorylation of c-Jun NH(2)-terminal kinase and p38 mitogen-activated protein kinase after transient forebrain ischemia in mice.2000
- Author(s)
  Takagi Y, Nozaki K, Sugino T, Hattori I, Hashimoto N.
- Journal Title
  
  Neurosci Lett 294
  
  Pages: 117-20
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390398
[Journal Article] Intravenous administration of thioredoxin decreases brain damage following transient focal cerebral ischemia in mice.
- Author(s)
  Hattori I, Takagi Y, Nakamura H, Nozaki K, Sugino T, Nishimura M, Hashimoto N, Yodoi J.
- Journal Title
  
  Antioxidants ＆ Redox Signaling 6
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390398
[Journal Article] Neuroprotective Role of A Peptide Inhibitor of c-Jun N-terminal Kinase on Global ischemia in Gerbils
- Author(s)
  Duysenbi S, Nozaki K, Takagi Y, Hayashi, HashimotoN.
- Journal Title
  
  (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390398
[Patent] モヤモヤ病関連遺伝子及びその利用2009
- Inventor(s)
  小泉昭夫, 永田和宏, 森戸大介, 高島成二, 山崎悟, 橋本信夫, 松浦範夫, 人見敏明
- Industrial Property Rights Holder
  京都大学,小泉昭夫,永田和宏,森戸大介,高島成二,山崎悟,橋本信夫,松浦範夫,人見敏明
- Industrial Property Number
  2009-244938
- Filing Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-17109007
[Patent] カテプシン阻害薬による脳血管障害の治療2008
- Inventor(s)
  橋本信夫、片岡大治、青木友浩
- Industrial Property Rights Holder
  京都大学
- Filing Date
  2008-06-08
- Data Source
  KAKENHI-PROJECT-19390377
[Patent] カテプシン阻害薬による脳血管障害の治療2008
- Inventor(s)
  橋本信夫、片岡大治、青木友浩
- Industrial Property Rights Holder
  京都大学
- Filing Date
  2008-06-08
- Data Source
  KAKENHI-PROJECT-19390377
[Patent] Edaravoneによる脳動脈瘤進展抑制効果2008
- Inventor(s)
  橋本信夫、片岡大治、青木友浩
- Industrial Property Rights Holder
  京都大学
- Filing Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-19390377
[Patent] edaravoneによる脳動脈瘤進展抑制効果2008
- Inventor(s)
  橋本信夫、片岡大治、青木友浩
- Industrial Property Rights Holder
  京都大学
- Filing Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-19390377
[Presentation] 家族性脳動脈家系の追跡調査および全ゲノム連鎖解析2009
- Author(s)
  箸方宏州, 山田茂樹, 峰晴陽平, 井上佳代子, 松浦範夫, 高木康志, 野崎和彦, 橋本信夫, 小泉昭夫, 宮本享
- Organizer
  第68回日本脳神経外科学会総会
- Place of Presentation
  京王プラザホテル
- Data Source
  KAKENHI-PROJECT-17109007
[Presentation] NF-kappaB 活性化を中心とした脳動脈瘤形成の分子機序の解明と臨床応用への展望2009
- Author(s)
  青木友浩, 西村真樹, 橋本信夫
- Organizer
  第34回日本脳卒中学会総会
- Place of Presentation
  松江
- Year and Date
  2009-03-20
- Data Source
  KAKENHI-PROJECT-19390377
[Presentation] 臨床に役立つグリオーマの遺伝子解析2009
- Author(s)
  白畑充章、橋本信夫、高橋潤、加藤菊也
- Organizer
  第11回癌治療増感研究シンポジウム
- Place of Presentation
  奈良
- Data Source
  KAKENHI-PROJECT-18390398
[Presentation] Clinical application of molecular diagnostics using gene expression profiling2008
- Author(s)
  白畑充章、橋本信夫、高橋潤、加藤菊也
- Organizer
  第26回日本脳腫瘍学会
- Place of Presentation
  松山
- Data Source
  KAKENHI-PROJECT-18390398
[Presentation] 脳動脈瘤家系の追跡調査2008
- Author(s)
  箸方宏州, 井上佳代子, 峰晴陽平, 劉万洋, 井上純子, 松浦範夫, 野崎和彦, 橋本信夫, 小泉昭夫
- Organizer
  第78回日本衛生学会総会
- Place of Presentation
  熊本市民会館
- Data Source
  KAKENHI-PROJECT-17109007
[Presentation] 片側もやもや病はもやもや病と異なる疾患か?家系を用いた遺伝学的検証2008
- Author(s)
  峰晴陽平, 高木康志, 菊田健一郎, 野崎和彦, 橋本信夫, 劉万洋, 松浦範夫, 井上純子, 井上佳代子, 小泉昭夫
- Organizer
  第33回日本脳卒中学会総会
- Place of Presentation
  京都国際会館
- Data Source
  KAKENHI-PROJECT-17109007
[Presentation] 遺伝子発現に基づいたanaplastic oligodendroglioma/glioblastoma診断モデル2008
- Author(s)
  白畑充章、橋本信夫、高橋潤、加藤菊也
- Organizer
  第26回日本脳腫瘍病理学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18390398
[Presentation] 遺伝子診断による脳血管障害の分類:中大脳動脈閉塞症、片側もやもや病、もやもや病は異なる疾患か?2008
- Author(s)
  峰晴陽平, 箸方宏州, 高木康志, 菊田健一郎, 野崎和彦, 橋本信夫, 劉万洋, 井上佳代子, 井上純子, 松浦範夫, 廣澤倫, 人見敏明, 皆田睦子, 小泉昭夫
- Organizer
  第33回日本脳卒中学会総会
- Place of Presentation
  京都国際会館
- Data Source
  KAKENHI-PROJECT-17109007
[Presentation] 悪性グリオーマに対するテモダール併用放射線治療後のpseudoprogressionについての検討2008
- Author(s)
  白畑充章、橋本信夫、高橋潤、加藤菊也
- Organizer
  第67回日本脳神経外科学会
- Place of Presentation
  盛岡
- Data Source
  KAKENHI-PROJECT-18390398
[Presentation] 遺伝子発現に基づいたanaplastic oligodendroglioma /glioblastoma診断モデル2007
- Author(s)
  白畑充章、橋本信夫、高橋潤、加藤菊也
- Organizer
  第66回日本脳神経外科学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18390398
[Presentation] Gliomaにおける遺伝子発現プロファイルの臨床的有用性について2007
- Author(s)
  白畑充章、,橋本信夫、高橋潤、加藤菊也
- Organizer
  第25回日本脳腫瘍学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18390398
[Presentation] 脳動脈瘤の遺伝要因2006
- Author(s)
  山田茂樹, 峰晴陽平, 高木康志, 野崎和彦, 井上佳代子, 小泉昭夫, 橋本信夫
- Organizer
  第7回日本分子脳神経外科学会
- Place of Presentation
  東京女子医科大学
- Data Source
  KAKENHI-PROJECT-17109007
[Presentation] 脳動脈瘤とTNF受容体の遺伝子多型～突然変異の同定～2006
- Author(s)
  峰晴陽平, 山田茂樹, 井上佳代子, 井上純子, 小泉昭夫, 野崎和彦, 橋本信夫
- Organizer
  第65回日本脳神経外科学会総会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-17109007

1. NOZAKI Kazuhiko (90252452)

# of Collaborated Projects: 14 results

# of Collaborated Products: 43 results
2. KOIZUMI Akio (50124574)

# of Collaborated Projects: 4 results

# of Collaborated Products: 27 results
3. YOSHINAGA Takeo (30025663)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. TAKAGI Yasushi (40312227)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
5. SUZUKI Michiyasu (80196873)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
6. KITA Toru (60161460)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. NAGATA Kazuhiro (50127114)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. NISHIDA Eisuke (60143369)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. TAKAHASHI Jun (10270779)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
10. HOJO Masato (60372588)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. KAGEYAMA Ryoichiro (80224369)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. MATSUDA Fumihiko (50212220)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
13. TOYOKUNI Shinya (90252460)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. INOUE Kayoko (30402829)

# of Collaborated Projects: 1 results

# of Collaborated Products: 24 results
15. TOYOSHIMA Megumi (80423052)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. HARADA Kouji (80452340)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. MINATA Mutsuko (00456857)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. HITOMI Toshiaki (90405275)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
19. KOBAYASHI Hatasu (70542091)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
20. TAKAHASHI Jun (80252435)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
21. KATO Kikuya (60194809)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
22. NISHIMURA Masaki (60452348)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
23. TAKAHASHI Ryosuke (90216771)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
24. KUME Noriaki (20252455)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. MATSUDA Masayuki (80026947)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 小杉眞司 (50252432)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 定藤章代 (60314192)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 滝和郎 (70144368)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 渡邊直樹 (80303816)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 荒川芳輝 (20378649)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 菊田健一郎 (90332725)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
32. 嘉山孝正 (50142972)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 吉田純 (40158449)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 片岡大治 (40359815)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
35. 宝子丸稔

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HASHIMOTO Nobuo 橋本 信夫

HASHIMOTO M. D. Nobuo 橋本 信夫

HASHIMOTO NOBUO 橋本 信夫

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Clarification of mechanisms and role of inflammation cascade during cerebral aneurysm formation and developmentPrincipal Investigator

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The molecular mechanisms of initiation, progression, rupture of cerebral aneurysms and development of a preventive treatment for itPrincipal Investigator

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悪性神経膠芽腫におけるRho情報伝達系による浸潤機構の解析と創薬の探索Principal Investigator

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HASHIMOTO Nobuo 橋本信夫

HASHIMOTO M. D. Nobuo 橋本信夫

HASHIMOTO NOBUO 橋本信夫