Kume Noriaki 久米典昭

… Alternative Names

Researcher Number	20252455
Affiliation (Current)	2019: 神戸学院大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2013 – 2017: 神戸学院大学, 薬学部, 教授 2012: 京都大学, 医学研究科, 講師 1998 – 2007: Kyoto University, Faculty of Medicine, Lecturer, 医学研究科, 講師 2005: 京都大学, 医学研究科, 助手 1999: 京都大学, 大学院・医学研究科, 講師 1995 – 1998: KYOTO UNIVERSITY,GRADUATE SCHOOL OF MEDICINE,INSTRUCTOR, 医学研究科, 助手 1993 – 1994: 京都大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Metabolomics / Metabolomics / Circulatory organs internal medicine / 内分泌・代謝学 Except Principal Investigator 内分泌・代謝学 / Metabolomics / Kidney internal medicine / Radiation science / Neurosurgery / Eating habits, studies on eating habits … More
Keywords	Principal Investigator LOX-1 / atherosclerosis / 酸化LDL / 粥状動脈硬化 / スカベンジャー受容体 / ADAM10 / lysophosphatidylcholine / CXCR6 / プラーク破綻 / 動脈硬化 … More Except Principal Investigator LOX-1 / 動脈硬化 / VCAM-1 / MCP-1 / マクロファージ / SR-PSOX / リゾフォスファチジルコリン / 酸化LDL / Tリンパ球 / 血管内皮細胞 / 粥状動脈硬化 / JAM / Rab4 / oxidized LDL / Lysophosphatidylcholine / WHHLウサギ / ICAM-1 / Egr-1 / 内皮細胞 / WHHL-rabbit / スカベンジャー受容体 / LDL / 接着分子 / HSP-70 / 単球接着分子 / 平滑筋細胞増殖因子 / トランスジェニックマウス / atherosclerosis / iNOS / 肝細胞 / lysophosphatidyl-choline / 酸化LDL受容体 / WHHL-ウサギ / 転写因子 / 血栓 / LDL受容体 / 家族性高コレステロール血症 / メサンギウム細胞 / Atherosclerosis / 血小板 / 不安定プラーク / MMP / MSW / ケモカイン / サイトカイン / TGF-β / VLDL / HB-EGF / MTP / トロンビン受容体 / endothelial cell / T lymphocyte / 単球 / 血小板活性化 / 細胞遊走 / 選別輸送 / 超小型放射線検出器 / vulnerable plaque / 可溶性レクチン様酸化型LDL受容体-1 / P-selectin / マウス / prostaglandin / Macrophage / cerebral aneurysmal / プロモーター / glucose derivative / 機能性成分 / T-lymphocytes / MRI / Cholesterol / アポ蛋白B-100 / 海藻 / グルコース誘導体 / Monocyte adhesion molecule / 伝統食 / Gsr6 / 調理 / Gas6 / 転写制御 / HB‐EGF / PDGF / E-box / Lysophosphatidyl-choline / 脳動脈瘤 / familial hypercholesterolemia atherosclerosis / 画像診断 / DNA複製因子C / Smooth muscle growth factor / endothelin / platelet / 糸球体硬化症 / 遺伝子 / 平滑筋細胞 / Vascular endothelial cell / endothelium / 血行力学的ストレス / 時計遺伝子 / molecular imaging / 泡沫細胞 / 家族性複合型高脂血症 / 動脈硬化症 / コレステロール代謝 / 概日リズム / P selection / gene / 顆粒放出 / CHO-cell / malotilate / PDGF-A, B鎖 / 頚動脈狭窄症 / PDGF-A,B chain / Cキナーゼ / plate activation / hemodynamic stress / Tlymphocyte / F-18 / 血液マーカー / mesangial cell / glomerulosclerosis / Monocyte / Hepatocytes / 脳梗塞 / リゾホスファチジルコリン / Athero ELAM / integrin / ラット / IV型コラーゲン / 血液バイオマーカー / 単クローン抗体 / 核転送 / Apo B-protein / 抗動脈硬化薬 / CHO-Cell / 細胞接着 / promoter / IL‐2受容体 / Adhesion molecule / Oxidized LDL / PDGF受容体 / 高血圧 / 放射線検出器 / 分化 / PDGF receptor / 増殖 / 放射性プローブ / コレステロール / 動物モデル / HMG-CoA還元酵素阻害剤 / Macrophages / T-lymphocyte / インテグリン / radiolabeled molecular probe / P selecTin / granule secretion / transcription factor / INF‐γ / プロスタグランディン / Oxidized LDL receptor / INF-gamma / THP1 / 分子イメージング / P selectin / PDGF-A,B鎖 / bHLH / macrophage / lectine-like oxidized LDL receptor / Transgenic mouse / thrombosis / チロシンリン酸化 / chemokine / radiation detector / Id Less

多機能メタロプロテアーゼによる概日リズム制御機構の解明Ongoing
- Principal Investigator
  
  平岡義範
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental physiology(including physical medicine and nutritional physiology)
- Research Institution
  Kobe Gakuin University
画像診断とバイオマーカーを用いた頚動脈不安定プラークの多角的診断法開発Ongoing
- Principal Investigator
  
  吉田和道
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  Kyoto University
Molecular mechanism and biomarkers for non-alcoholic steatohepatitisPrincipal Investigator
- Principal Investigator
  
  Kume Noriaki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kobe Gakuin University
Wisdom of seaweed foods in fishing village ?Application to modern dishes-
- Principal Investigator
  
  TOYOYHARA Masako
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Eating habits, studies on eating habits
- Research Institution
  京都華頂大学
   Kacho Junior College
Novel functions of lectin-like oxidized LDL receptor-1 (LOX-1)Principal Investigator
- Principal Investigator
  
  KUME Noriaki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kyoto University
Molecular mechanism of the process from atherosclerotic lesion formation to plaque rupture
- Principal Investigator
  
  KITA Toru
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Metabolomics
- Research Institution
  Kyoto University
Molecular imaging for noninvasive evaluation of atherosclerotic plaque vulnerability
- Principal Investigator
  
  SAJI Hideo
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  Kyoto University
Oxidized LDL receptors, LOX-1 and SE-PSOX and their soluble moleculesPrincipal Investigator
- Principal Investigator
  
  KUME Noriaki
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kyoto University
Pathopysiological roles of a novel oxidized LDL receptor, SR-PSOXPrincipal Investigator
- Principal Investigator
  
  KUME Noriaki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  KYOTO UNIVERSITY
Elucidation of molecular mechanism of atherosclerosis formation
- Principal Investigator
  
  YOKODE Msayuki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Metabolomics
- Research Institution
  KYOTO UNIVERSITY
Molecular mechanisms of cerebral aneurysmal formation
- Principal Investigator
  
  HASHIMOTO Nobuo
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kyoto University
Molecular mechanism of activation of endothelial cells involved in early stage of atherosclerosis formation.
- Principal Investigator
  
  KITA Toru
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (A).
- Research Field
  
  Metabolomics
- Research Institution
  KYOTO UNIVERSITY
Cell biological study for atherosclerosis
- Principal Investigator
  
  KITA Toru
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (A).
- Research Field
  
  Metabolomics
- Research Institution
  KYOTO UNIVERSITY
Pathophysiological roles of LOX-1, a novel receptor of oxidized LDLPrincipal Investigator
- Principal Investigator
  
  KUME Noriaki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Institution
  KYOTO UNIVERSITY
メサンギウム細胞分化を決定する新たな転写因子のクローニング-腎障害の形質変換における機能解析
- Principal Investigator
  
  土井俊夫
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Kidney internal medicine
- Research Institution
  Kyoto University
Investigation for progressive factors of glomerulosclerosis.
- Principal Investigator
  
  DOI Toshio
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokushima
  Kyoto University
動脈硬化発症・進展の分子機構
- Principal Investigator
  
  KITA Toru
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kyoto University
粥状動脈硬化の発生、進展に及ぼすトロンビン受容体の影響に関する研究
- Principal Investigator
  
  ISHII Kenji
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyoto University
Expression of adhesion molecules and growth factors in vascular endothelial cellPrincipal Investigator
- Principal Investigator
  
  KUME Noriaki, 越智弘
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  KYOTO UNIVERSITY
Molecular mechanism on the progression of atherosclerosis.
- Principal Investigator
  
  KITA Toru
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  KYOTO UNIVERSITY
Development of new drug for intractable hyperlipidemia and its clinical application
- Principal Investigator
  
  KITA Toru
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  内分泌・代謝学
- Research Institution
  KYOTO UNIVERSITY
発生工学を応用した小胞体輸送機構の研究-LDL受容体を発現するトランスジェニックマウスを用いて-
- Principal Investigator
  
  YOKODE Masayuki
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
Regulation of VCAM-1 and ICAM-1 expression in atherogenesisPrincipal Investigator
- Principal Investigator
  
  KUME Noriaki
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  KYOTO UNIVERSITY
Studies on the initiation and regression of atherosclerosis
- Principal Investigator
  
  KITA Toru
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Kyoto University
Gene engineering, cell biological aproaches to the mechanisms for early stage of atherosclerosis
- Principal Investigator
  
  KITA Toru
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  内分泌・代謝学
- Research Institution
  KYOTO UNIVERSITY
Development and clinical application of novel anti-atherogenic drug.
- Principal Investigator
  
  KITA Toru
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  KYOTO UNIVERSITY

All 2017 2016 2015 2014 2013 2008 2007 2006 2005 2004

All Journal Article Presentation

[Journal Article] Comparison of serum lipid management between elderly and non-elderly patients with and without coronary heart disease (CHD).2016
- Author(s)
  Nishi K, Sato Y, Ohno M, Hiraoka Y, Saijo S, Sakamoto J, Chen PM, Morita Y, Matsuda S, Iwasaki K, Sugizaki K, Harada N, Mukumoto Y, Kiyonari H, Furuyama K, Kawaguchi Y, Uemoto S, Kita T, Inagaki N, Kimura T, Nishi E.
- Journal Title
  
  Prev Med Rep.
  
  Volume: 65 Pages: 3015-27
- DOI
  10.1016/j.pmedr.2016.06.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08536
[Journal Article] Plasma soluble lectin-like oxidized low-density lipoprotein receptor-1 as a novel prognostic biomarker in patients with ST-segment elevation acute myocardial infarction.2015
- Author(s)
  Higuma T, Abe N, Tateyama S, Endo T, Shibutani S, Yokoyama H, Harada K, Yamada M, Tomita H, Hanada H, Osanai T, Kume N, Okumura K
- Journal Title
  
  Cieculation Journal
  
  Volume: in press
- Open Access / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461369
[Journal Article] Serum lipid goal attainment in chronic kidney disease (CKD) under the Japan Atherosclerosis Society 2012 guideline: a single center study2015
- Author(s)
  Shimizu R, Torii H, Yasuda D, Hiraoka Y, Kitada N, Hashida T, Yoshimoto A, Kita T, Kume N
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis
  
  Volume: in press
- Open Access / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461369
[Journal Article] MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit recuced HDL-C in vivo.2014
- Author(s)
  Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Nakazeki F, Ide Y, Koyama S, Sowa N, Yahagi N, Shimano H, Nakamura T, Hasegawa K, Kume N, Yokode M, Kita T, Kimura T, Ono K.
- Journal Title
  
  Sci Rep
  
  Volume: 4 Pages: 5312-5312
- DOI
  10.1038/srep05312
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-14J05148, KAKENHI-PUBLICLY-25126701, KAKENHI-PROJECT-25293182, KAKENHI-PROJECT-25461369, KAKENHI-PROJECT-25670383, KAKENHI-PUBLICLY-26116716, KAKENHI-PROJECT-26461144, KAKENHI-PROJECT-26670147, KAKENHI-PROJECT-26670448, KAKENHI-PROJECT-26860556, KAKENHI-PLANNED-23116006
[Journal Article] MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice2013
- Author(s)
  Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Sowa N, Yahagi N, Shimano H, Matsumura S, Inoue K, Marusawa H, Nakamura T, Hasegawa K, Kume N, Yokode M, Kita T, Kimura T, Ono K
- Journal Title
  
  Nature Commun
  
  Volume: 4:2883 Pages: 1-12
- DOI
  10.1038/ncomms3883
- Open Access / Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23116006, KAKENHI-PROJECT-23390211, KAKENHI-PUBLICLY-24116512, KAKENHI-PROJECT-24390230, KAKENHI-PROJECT-24790753, KAKENHI-PROJECT-24890094, KAKENHI-PUBLICLY-25126701, KAKENHI-PROJECT-25293182, KAKENHI-PROJECT-25461369, KAKENHI-PROJECT-25462136, KAKENHI-PROJECT-25670383
[Journal Article] Soluble lectin-like oxidized LDL receptor-1 (sLOX-1) as a valuable diagnostic marker for rupture of thin-cap fibroatheroma: verification by optical coherence tomography2013
- Author(s)
  Kobayashi N, Takano M, Hata N, Kume N, Yamamoto M, Yokoyama S, Shinada T, Tomita K, Shirakabe A, Otsuka T, Seino Y, Mizuno K:
- Journal Title
  
  International Journal of Cardiology
  
  Volume: 168 Pages: 3217-3223
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461369
[Journal Article] Interleukin 18 stimulates release of soluble lectin-like oxidized LDL receptor-1 (sLOX-1)2008
- Author(s)
  Mitsuoka H, Kume N, et. al.:
- Journal Title
  
  Atherosclerosis (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590985
[Journal Article] Lectin-like oxidized LDL receptor-1 (LOX-1) acts as a receptor for remnant-like lipoprotein particles (RLPs) and mediates RLP-induced migration of vascular smooth muscle cells2008
- Author(s)
  Aramaki, Y., Kume, N., et. al.
- Journal Title
  
  Atherosclerosis (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590985
[Journal Article] Interleukin 18 stimulates release of soluble lectin-like oxidized LDL receptor-1 (sLOX-1)2008
- Author(s)
  Mitsuoka, H., Kume, N., et. al.
- Journal Title
  
  Atherosclerosis (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590985
[Journal Article] Interleukin 18 stimulates release of soluble lectin-like oxidized LDL receptor-1(sLOX-1)2008
- Author(s)
  Mitsuoka H, Kume N, et. al.:
- Journal Title
  
  Atherosclerosis (印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590985
[Journal Article] Lectin-like oxidized LDL receptor-1(LOX-1)acts as a receptor for remnant-like lipoprotein particles(RLPs)and mediates RLP-induced migration of vascular smooth muscle cells2008
- Author(s)
  Aramaki Y, Kume N, et. al.:
- Journal Title
  
  Atherosclerosis (印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590985
[Journal Article] Lectin-like oxidized LDL receptor-1 (LOX-1) acts as a receptor for remnant-like lipoprotein particles (RLPs)2008
- Author(s)
  Aramaki Y, Kume N, et. al.:
- Journal Title
  
  Atherosclerosis (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590985
[Journal Article] Lectin-like oxidized LDL receptor-1 (LOX-1) expression is associated with atherosclerotic plaque instability-analysis in hypercholesterolemic rabbits.2007
- Author(s)
  S.Ishino, T.Mukai, N.Kume, D.Asano, M.Ogawa, Y.Kuge, M.Minami, T.Kita, M.Shiomi, H.Saji.
- Journal Title
  
  Atherosclerosis (印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390337
[Journal Article] Lectin-like oxidized LDL receptor-1 (LOX-1) expression is associated with atherosclerotic plaque instability-analysis in hypercholesterolemic rabbits.2007
- Author(s)
  Ishino S, Mukai T, Kume N, Asano D, Ogawa M, Kuge Y, Minami M, Kita T, Shiomi M, Saji H.
- Journal Title
  
  Atherosclerosis. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390337
[Journal Article] Lectin-like oxidized LDL receptor-1(LOX-1)expression is associated with plaque instability-analysis in hypercholesterolemic rabbits2007
- Author(s)
  Ishino S, Mukai T, Kume N, et. al.:
- Journal Title
  
  Atherosclerosis 195
  
  Pages: 48-56
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590985
[Journal Article] Lectin-like oxidized LDL receptor-1 (LOX-1) expression is associated with plaque instability-analysis in2007
- Author(s)
  Ishino S, Mukai T, Kume N, et. al.:
- Journal Title
  
  Atherosclerosis 195
  
  Pages: 48-56
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590985
[Journal Article] Lectin-like oxidized LDL receptor-1 (LOX-1) expression is associated with plaque mstability-analysis in hypercholesterolemic rabbits2007
- Author(s)
  Ishino, S., Mukai, T., Kume, N, et. al.
- Journal Title
  
  Atherosclerosis 195
  
  Pages: 48-56
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590985
[Journal Article] A catheter-based intravascular radiation detector of vulnerable plaques.2006
- Author(s)
  R.Hosokawa, N.Kambara, M.Ohba, T.Mukai, M.Ogawa, H.Motomura, N.Kume, H.Saji, T.Kita, R.Nohara
- Journal Title
  
  J.Nucl.Med. 47(5)
  
  Pages: 863-867
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390337
[Journal Article] A catherer-based intravascular radiation detector for vulnerable plaques.2006
- Author(s)
  R.Hosokawa, N.Kambara, M.Ohba, T.Mukai, M.Ogawa, H.Motomura, N.Kume, H.Saji, T.Kita, R.Nohara
- Journal Title
  
  J. Nucl. Med. 47・5
  
  Pages: 863-867
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390337
[Journal Article] Serum soluble lectin-like oxidized low-density lipoprotein receptor-1 levels are elevated in acute coronary syndrome. A novel marker for early diagnosis2005
- Author(s)
  Hayashida, K., Kume, N., Murase, T., Minami, M., Nakagawa, D., Inada, T., Tanaka, M., Ueda, A., Kominami, G., Kambara, H., Kimura, T., Kita, T
- Journal Title
  
  Circulation 112
  
  Pages: 812-818
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590880
[Journal Article] CXCL16 is a novel angiogenic factor for human umbilical vein endothelial cells.2005
- Author(s)
  Zhuge X, . Murayama T, Arai H, Yamauchi R, Tanaka M, Shimaoka T, Yonehara S, Kume N, Yokode M, Kita T
- Journal Title
  
  Biochem. Biophys. Res. Commun 331
  
  Pages: 1295-1300
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16590880
[Journal Article] Serum soluble lectin-like oxidized low-density lipoprotein receptor-1 levels are elevated in acute coronary syndrome. A novel marker for early diagnosis.2005
- Author(s)
  Hayashida K, Kume N, Murase T, Minami M, Nakagawa D, Inada T, Tanaka M Ueda A, Kominami G, Kambara H, Kimura T, Kita T
- Journal Title
  
  Circulation 112
  
  Pages: 812-818
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16590880
[Journal Article] CXCL16 is a novel angiogenic factor for human umbilical vein endothelial cells2005
- Author(s)
  Xin, Zhuge, Toshinori, Murayama, Hidenori, Arai, Ryoko, Yamauchi, Makoto, Tanaka, Takeshi, Shimaoka, Shin, Yonehara, Noriaki, Kume, Masayuki, Yokode, Toru, Kita
- Journal Title
  
  Biochem. Biophys. Res. Commun 331
  
  Pages: 1295-1300
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590880
[Journal Article] Serum soluble ectin-like oxidized low-density lipoprotein recepfor-1 levels are elevated in acute coronary syndrome. A novel marker for early diagnosis.2005
- Author(s)
  Kazutaka Hayashida, Noriaki Kume, Takatoshi Murase T, Manabu Minami, Daisuke Nakagawa, Tsukasa Inada, Masaru Tanaka Akira Ueda, Goro Kominami, Horofumi Kambara, Takeshi Kimura, Toru Kita
- Journal Title
  
  Circulation 112
  
  Pages: 812-818
- Data Source
  KAKENHI-PROJECT-16590880
[Journal Article] CXCL16 is a novel agiogenic factor for human umbilical vein endothelial cells.2005
- Author(s)
  Xin Zhuge, Toshinori Murayama, Hidenori Arai, Ryoko Yamauchi, Makoto Tanaka, Takeshi Shimaoka, Shin Yonehara, Noriaki Kume, Masayuki Yokode, Toru Kita
- Journal Title
  
  Biochem.Biophys.Res.Commun 331
  
  Pages: 1295-1300
- Data Source
  KAKENHI-PROJECT-16590880
[Journal Article] Apoposis of vascular cells by oxidized LDL: involvement of caspases and LOX-1, and its implication in atherosclerotic plaque rupture.2004
- Author(s)
  Kume N, Kita T
- Journal Title
  
  Circulation Research 94
  
  Pages: 269-270
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16590880
[Journal Article] Heparin-binding EGF-like growth factor induces expression of lectin-like oxidized-LDL receptor-1 in vascular smooth muscle cells.2004
- Author(s)
  Mukai E, Kume N, et. al.
- Journal Title
  
  Atherosclerosis 176
  
  Pages: 289-296
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16590880
[Journal Article] Upregulation of SR-PSOX/CXCL16 and recruitment of CD8+T cells in cardiac Valves in inflammatory valvular heart disease.2004
- Author(s)
  Yamauchi R, Tanaka M, Kume N, et. al.
- Journal Title
  
  Arteriosclerosis, Thrombosis and Vascular Biology 24
  
  Pages: 282-287
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16590880
[Journal Article] Upregulation of SR-PSOX/CXCL16 and recruitment of CD8+T cells in cardiac2004
- Author(s)
  Yamauchi R, Tanaka M, Kume N, et al.
- Journal Title
  
  Arteriosclerosis, Thrombosis and Vascular Biology 24巻
  
  Pages: 282-287
- Data Source
  KAKENHI-PROJECT-16590880
[Journal Article] Apoposis of vascular cells by oxidized LDL : involvement of spases and LOX-1 and2004
- Author(s)
  Kume N, Kita T
- Journal Title
  
  Circulation Research 94巻
  
  Pages: 269-270
- Data Source
  KAKENHI-PROJECT-16590880
[Journal Article] Apoposis of vascular cells by oxidized LDL : involvement of cspases and LOX-1, and its implication in atherosclerotic plaque rupture2004
- Author(s)
  Kume, N., Kita, T
- Journal Title
  
  Circulation Research 94
  
  Pages: 269-270
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590880
[Journal Article] Peroxisome proliferator-activated receptor alpha ligands activate transcription of lectin-2004
- Author(s)
  Hayashida K, Kume N, et al.
- Journal Title
  
  Biochemical Biophysical Research Communication 323巻
  
  Pages: 1116-1123
- Data Source
  KAKENHI-PROJECT-16590880
[Journal Article] Heparin-binding EGF-like growth factor induces expression of lectin-like oxidized2004
- Author(s)
  Mukai E, Kume N, et al.
- Journal Title
  
  Ahterosclerosis 176巻
  
  Pages: 289-296
- Data Source
  KAKENHI-PROJECT-16590880
[Journal Article] Peroxisome proliferator-activated receptor alpha ligands activate transcription of lectin-like oxidized LDL rceptor-1 gene through GC box motif2004
- Author(s)
  Hayashida K, Kume N, et. al.
- Journal Title
  
  Biochemical Biophysical Research Communication 323
  
  Pages: 1116-1123
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16590880
[Journal Article] Heparin-binding EGF-like growth factor induces expression of lectin-like oxidized LDL receptor-1 in vascular smooth muscle cells2004
- Author(s)
  Mukai, E., Kume, N., et. al.
- Journal Title
  
  Atherosclerosis 176
  
  Pages: 289-296
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590880
[Journal Article] Peroxisome proliferator-activated receptor alpha ligands activate transcription of lectin-like oxidized LDL receptor-1 through GC box motif2004
- Author(s)
  Hayashida, K., Kume, N., et. al.
- Journal Title
  
  Biochemical Biophysical Research Communication 323
  
  Pages: 1116-1123
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590880
[Journal Article] Upregulation of SR-PSOX/CXCL16 and recruitment of CD8+T cells in cardiac valves during inflammatory valvular heart disease2004
- Author(s)
  Yamauchi, R., Tanaka, M., Kume, N., et. al.
- Journal Title
  
  Arteriosclerosis, Thrombosis and Vascular Biology 24
  
  Pages: 282-287
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590880
[Presentation] Nardilysin regulates the mammalian circadian clock via modulating PER2 function2017
- Author(s)
  Yoshinori Hiraoka, Hikari Yoshitane, Mikiko Ohno, Yusuke Morita, Rina Nunokawa, Kiyoto Nishi, Noriaki Kume, Takeshi Kimura, Yoshitaka Fukada and Eiichiro Nishi.
- Organizer
  European Biological Rhythms Society XV Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08536
[Presentation] ナルディライジンによるPER2を介した概日リズム制御機構2017
- Author(s)
  平岡義範、吉種光、大野美紀子、森田雄介、布川莉奈、西清人、久米典昭、木村剛、深田吉孝、西英一郎
- Organizer
  第24回日本時間生物学会学術大会
- Data Source
  KAKENHI-PROJECT-16K08536
[Presentation] ナルディライジンによるPER2の機能調節を介した概日リズム制御機構2017
- Author(s)
  平岡義範、吉種光、大野美紀子、森田雄介、布川莉奈、西清人、久米典昭、木村剛、深田吉孝、西英一郎
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-16K08536
[Presentation] ナルディライジンによる概日リズム制御機構の解明2016
- Author(s)
  平岡義範、吉種光、大野美紀子、布川莉奈、西清人、森田雄介、久米典昭、木村剛、深田吉孝、西英一郎
- Organizer
  第23回(2016年度)日本時間生物学会学術大会
- Place of Presentation
  名古屋
- Year and Date
  2016-11-12
- Data Source
  KAKENHI-PROJECT-16K08536
[Presentation] Interleukin 18 stimulates release of soluble lectin-like oxidized LDL receptor-1 (sLOX-1)2007
- Author(s)
  Mitsuoka H, Kume N, et. al.:
- Organizer
  日本心臓病学会
- Place of Presentation
  浦安市
- Year and Date
  2007-09-11
- Data Source
  KAKENHI-PROJECT-18590985
[Presentation] Lectin-like oxidized LDL receptor-1 (LOX-1) acts as a receptor for remnant-like lipoprotein particles (RLPs) and mediates RLP-induced migration of vascular smooth muscle cells2006
- Author(s)
  Aramaki, Y., Kume, N., et. al.
- Organizer
  ACC2006
- Place of Presentation
  Atlanta
- Year and Date
  2006-03-11
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590985
[Presentation] Lectin-like oxidized LDL receptor-1(LOX-1)acts as a receptor for remnant-like lipoprotein particles(RLPs)and mediates RLP-induced migration of vascular smooth muscle cells2006
- Author(s)
  Aramaki Y, Kume N, et. al.:
- Organizer
  米国心臓病学会(ACC)
- Place of Presentation
  アトランタ(米国)
- Year and Date
  2006-03-11
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590985

1. YOKODE Masayuki (20252447)

# of Collaborated Projects: 13 results

# of Collaborated Products: 0 results
2. KITA Toru (60161460)

# of Collaborated Projects: 11 results

# of Collaborated Products: 0 results
3. ISHII Kenji (00212811)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
4. DOI Toshio (60183498)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
5. ARAI Hidenori (60232021)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
6. WAKATSUKI Yoshio (40220826)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
7. HORIUCHI Hisanori (90291426)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
8. UEDA Yukihiko (70252434)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
9. TANAKA Makoto (00271007)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
10. HIRAOKA Yoshinori (60397552)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
11. OCHI Hiroshi (80204220)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. CHAIT Alan

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. GIMBRONE Mic

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. TOYOYHARA Masako (50241211)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. MURAKAMI Motonobu (10157761)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. MURAKAMI Takashi (40210009)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. MIZUNO Akira (80219641)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. KUWAJIMA Masamichi (00205262)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. HASHIMOTO Nobuo (40135570)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. NOZAKI Kazuhiko (90252452)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. NAGATA Kazuhiro (50127114)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. HASEGAWA Koji (50283594)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. SAJI Hideo (40115853)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
24. KUGE Yuji (70321958)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
25. TADAMURA Eiji (70303831)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. NOHARA Ryuji (80180769)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
27. MUKAI Takahiro (30284706)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
28. 家原典之 (20281727)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 袴田康弘 (30261233)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 吉岡秀幸 (30231690)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 吉田和道 (90598921)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 西英一郎 (30362528)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
33. HAMAGUTHI Hiroshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. GIMBRONE Michael A.jr.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. MICHAEL A. G

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. ALAN Chait

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. CYBULSKI Myr

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. GIMBRONE Jr

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. CYBULSKY Myron I

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. GIMBRONE Michael A.Jr

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
41. CYBULSKY Myr

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
42. HORIE Takahiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
43. KUWABARA Yasuhide

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
44. KIMURA Takeshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
45. 矢作直也

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
46. 尾野亘

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
47. 中邨智之

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
48. 島野仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Kume Noriaki 久米 典昭

KUME Noriaki 久米 典昭

Research Projects

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Co-Researchers

多機能メタロプロテアーゼによる概日リズム制御機構の解明Ongoing

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画像診断とバイオマーカーを用いた頚動脈不安定プラークの多角的診断法開発Ongoing

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Molecular mechanism and biomarkers for non-alcoholic steatohepatitisPrincipal Investigator

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Novel functions of lectin-like oxidized LDL receptor-1 (LOX-1)Principal Investigator

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Oxidized LDL receptors, LOX-1 and SE-PSOX and their soluble moleculesPrincipal Investigator

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Pathopysiological roles of a novel oxidized LDL receptor, SR-PSOXPrincipal Investigator

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Pathophysiological roles of LOX-1, a novel receptor of oxidized LDLPrincipal Investigator

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Kume Noriaki 久米典昭

KUME Noriaki 久米典昭