AKATSU Hiroyasu 赤津裕康

Researcher Number	00399734
Other IDs
Affiliation (Current)	2021: 名古屋市立大学, 医薬学総合研究院(医学), 教授 2021: 医療法人さわらび会福祉村病院長寿医学研究所, 長寿医学研究所, 研究員
Affiliation (based on the past Project Information) *help	2019 – 2020: 名古屋市立大学, 医薬学総合研究院(医学), 教授 2016 – 2019: 名古屋市立大学, 大学院医学研究科, 教授 2018: 医療法人さわらび会福祉村病院長寿医学研究所, 長寿医学研究所, 研究員 2017: 医療法人さわらび会福祉村病院, 長寿医療研究所, 研究員 2015 – 2016: 医療法人さわらび会福祉村病院, 長寿医学研究所, 研究員 … More
Review Section/Research Field	Principal Investigator Nerve anatomy/Neuropathology / Human pathology / Basic Section 58080:Gerontological nursing and community health nursing-related Except Principal Investigator Psychiatric science / Biological Sciences / Applied biochemistry / Neurochemistry/Neuropharmacology / 膠原病・アレルギー・感染症内科学 / Social dentistry / Hygiene and public health … More
Keywords	Principal Investigator アンギオテンシン変換酵素 / アルツハイマー病 / アミロイド / 遺伝子多型 / 高齢者タウオパチ― / 補体 / 鉄 / 神経源線維変化 / 嗜銀顆粒 / 高齢者タウオパチー … More Except Principal Investigator アルツハイマー病 / 認知症 / 関節リウマチ / シノビオリン / 滑膜細胞増殖 / 転写制御 / E3ユビキチンリガーゼ / 診断 / 基質 / ノックアウトマウス / ABC蛋白質 / 動脈硬化 / コレステロール / iPS細胞 / トランスポーター / モデル動物 / 脳神経疾患 / アミロイドβ / 神経科学 / 多因子疾患 / ゲノム / Dynamin2 / アミロイドβ蛋白 / APPトランスジェニックマウス / リスク遺伝子 / SORL1 / KIBRA / 罹患同胞対 / ダイナミン / 第21染色体 / 第12染色体短腕 / アポリポ蛋白E / 第八因子 / SURB遺伝子 / アポリポ蛋白C1 / アポリポ蛋白C2 / ESコビキチンリガーゼ / 転写複合体 / 動物生化学 / 膜輸送タンパク質 / 膜タンパク質 / 神経疾患 / 生活習慣病 / 1分子イメージング / ABCタンパク質 / 善玉コレステロール / ケミカルライブラリー / ES細胞 / 1分子観察 / 核内受容体 / 蛋白質相互作用 / ACBタンパク質 / アルツハイマー / タンパク質精製 / プロテアソーム / 遺伝病 / 小胞体ストレス / 線維化 / 分泌タンパク質 / 慢性炎症 / コンディショナルノックアウト / アポトーシス / 肝硬変 / サイトカイン / 滑膜細胞細胞 / 分泌 / ユビキチン化 / 小胞体関連分解 / 滑膜細胞 / コンディショナルノックアウトマウス / 化合物 / 生化学的手法 / T細胞 / 脳科学 / 研究支援 / 研究集会 / 研究リソース / 技術開発 / 若手研究者育成支援 / 研究リソース支援 / 技術開発支援 / ブレインバンク / 脳画像データベース / 脳分子プロファイル / ウイルスベクター / 統合失調症 / 死後脳研究 / プロテオミクス / 質量分析 / 死後脳 / LC-MS/MS / 増殖シグナル / 結晶構造解析 / 神経細胞 / 1分子生物学 / 構造生物学 / 膜環境 / 多能性幹細胞 / 阻害剤 / 中枢神経細胞 / 3次元構造解析 / HCNP / 平野小体 / 顆粒空胞変性 / HCNP前駆体 / リン酸化 / 前駆体蛋白 / 鼻粘膜 / 神経病理 / ドーパミン / アセチルコリン / 認知機能 / レビー小体型認知症 / アルツハイマー型認知症 / 海馬 / 施設入所 / 運動機能 / 中隔核 / 対角核 / dopamine / acetylcholine / cognitive function / dementia with Lewv bodies / Alzheimer's disease / hippocampus / institution placement / motor function / 歯周病 / 口腔ケア / 認知症予防 / 歯牙欠損 / ソフトダイエット / 咀嚼機能低下 / 認知症進行抑止 / 介入試験 / 生体試料支援 / コホート / 臨床検体 / 一般健常人 / 大規模ゲノム解析 / 大規模ゲノム解析・オミックス解析 / オミックス解析 / アドバンス・ケア・プランニング / オンライン・クラウド型 / 地域医療 / 終末期ケア / 事前指示書 / クラウド型オンラインシステム / 疾患リスク遺伝子 / オミックス / マウス背景遺伝子 / トランスクリプトーム解析 / 網羅的解析 / 疾患修飾遺伝子 / トランスクリプトーム / トランスレーショナル研究 / 認知症スクリーニング / 医療・福祉サービス / 発話音声・脳血流解析 / 前頭側頭葉変性症 / 地域多様性 / 炎症性腸疾患 / ラクトフェリン / 大腸がん / 神経化学 / 核磁気共鳴画像 / 脳神経 / ベータアミロイド / タウプロテイン / アミロイドオリゴマー / 治療 / タウタンパク / AI / 組織細胞化学 / 新興感染症 / COVID-19 / 疾病集積性 / 空間疫学 / 重症化要因 Less

Creating a fall prevention program that the elderly can evaluate their walk-style by developing our three-dimensional acceleration sensorPrincipal InvestigatorOngoing
- Principal Investigator
  
  赤津裕康
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 58080:Gerontological nursing and community health nursing-related
- Research Institution
  Nagoya City University
Development of AI technology to detect prion activity of pathogenic proteins in nasal mucosa and its application to diagnosis of dementiaOngoing
- Principal Investigator
  
  遠山育夫
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 46:Neuroscience and related fields
- Research Institution
  Shiga University of Medical Science
International cooperative study for spatial-temporal disease clustering and risk factors on emerging infectious diseasesOngoing
- Principal Investigator
  
  間辺利江
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 58:Society medicine, nursing, and related fields
- Research Institution
  Jichi Medical University
A Cross-Sectional Study on Disease and Regional Diversity of Cognitive Impairment in Elderly Using Speech Analysis and Cerebral Blood Flow ActivationOngoing
- Principal Investigator
  
  加藤昇平
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 62:Applied informatics and related fields
- Research Institution
  Nagoya Institute of Technology
ラクトフェリンによる炎症性腸疾患の発症予防と寛解維持および発がん予防効果Ongoing
- Principal Investigator
  
  田中創始
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Nagoya City University
ヒト脳内での２段階にわたるアミロイドβ蓄積の機序の解明Ongoing
- Principal Investigator
  
  篠原充
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  National Center for Geriatrics and Gerontology
The research of pathological condition for clinical diagnosis of tangle only dementiaPrincipal Investigator
- Principal Investigator
  
  Hiroyasu Akatsu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Nagoya City University
Development of online system about Advanced Directive of Living Will and its efficacy assessmentOngoing
- Principal Investigator
  
  兼松孝好
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hygiene and public health
- Research Institution
  Nagoya City University
Simultaneous analysis of Aß oligomers, Aß fibrils and phosphrylated tau protein using fluroine-MRIOngoing
- Principal Investigator
  
  遠山育夫
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Shiga University of Medical Science
A study to elucidate mechanism, by which periodontists inducing memory impairment and to determine effect of its intervention on progression of dementia.
- Principal Investigator
  
  Michikawa Makoto
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Social dentistry
- Research Institution
  Nagoya City University
コホート・生体試料支援プラットフォームOngoing
- Principal Investigator(Support)
  
  今井浩三
- Project Period (FY)
  2016 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas ― Platforms for Advanced Technologies and Research Resources
- Research Institution
  The University of Tokyo
Determinations of nasal biomarkers for dementia and development of a novel diagnostic method for Alzheimer's disease using nasal samples.
- Principal Investigator
  
  Tooyama Ikuo
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Shiga University of Medical Science
Alzheimer disease modifier gene: Identification by novel transcriptions and functional analysis
- Principal Investigator
  
  Morihara Takashi
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Osaka University
Molecular mechanism of ABC proteins involved in cholesterol homeostasis
- Principal Investigator
  
  Ueda Kazumitsu
- Project Period (FY)
  2013 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Applied biochemistry
- Research Institution
  Kyoto University
The involvemnt of HCNP precursor in formation of hirano body and granulovascuolar degeneration
- Principal Investigator
  
  Matsukawa Noriyuki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Nagoya City University
A study for the correlation between Alzheimer's disease and angiotensin converting enzyme in human samplesPrincipal Investigator
- Principal Investigator
  
  AKATSU Hiroyasu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Choju Medical Institute, Fukushimura Hospital.
Global and target-oriented proteomic analysis in the postmortem brains from patients with schizophrenia
- Principal Investigator
  
  KUNII Yasuto
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Fukushima Medical University
Comprehensive Brain Science Network
- Principal Investigator
  
  Kimura Minoru
- Project Period (FY)
  2010 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  Center for Novel Science Initatives, National Institutes of Natural Sciences
二元的アポトーシス制御因子シノビオリンを標的としたがん研究
- Principal Investigator
  
  NAKAJIMA Toshihiro
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Choju Medical Institute, Fukushimura Hospital.
シノビオリンの二方向性シグナル制御の生物学的意義
- Principal Investigator
  
  中島利博
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Choju Medical Institute, Fukushimura Hospital.
Physiological substrates and functions of ABC proteins involved in lipid transport
- Principal Investigator
  
  UEDA Kazumitsu
- Project Period (FY)
  2008 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Applied biochemistry
- Research Institution
  Kyoto University
Integrated study on implication of Synoviolin in multiprocesses of rheumatoid arthritis.
- Principal Investigator
  
  NAKAJIMA Toshihiro
- Project Period (FY)
  2008 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Tokyo Medical University
  Choju Medical Institute, Fukushimura Hospital.
Genetic study on Alzheimer Disease
- Principal Investigator
  
  TAKEDA Masatoshi
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Comprehensive research project of diagnosis and treatment of dementia with Lewy bodies
- Principal Investigator
  
  UMEGAKI Hiroyuki
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Nagoya University

[Book] Curcumin against amyloid pathology in mental health and brain composition.; In Health Fruits, Vegetables, and Herbs: Bioactive Foods in Promoting Edited by Ronald Watson and Victor Preedy2016
- Author(s)
  Ikuo Tooyama, Nor Faeizah Ibrahim, Lina Wati Durani, Hamizah Shahirah Hamezah, Mohd Hanafi Ahmad Damanhuri, Wan Zurinah Wan Ngah, Hiroyasu Taguchi, Daijiro Yanagisawa
- Total Pages
  19
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-26640042
[Journal Article] Comprehensive quantification of purine and pyrimidine metabolism in Alzheimer's disease postmortem cerebrospinal fluid by LC?MS/MS with metal‐free column2020
- Author(s)
  Muguruma Yoshio、Tsutsui Haruhito、Akatsu Hiroyasu、Inoue Koichi
- Journal Title
  
  Biomedical Chromatography
  
  Volume: 34
- DOI
  10.1002/bmc.4722
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08725
[Journal Article] Beta-Amyloid Increases the Expression Levels of Tid1 Responsible for Neuronal Cell Death and Amyloid Beta Production.2020
- Author(s)
  Zhou C, Taslima F, Abdelhamid M, Kim SW, Akatsu H, Michikawa M, Jung CG.
- Journal Title
  
  Mol Neurobiol.
  
  Volume: Feb;57(2): Pages: 1099-1114
- DOI
  10.1007/s12035-019-01807-2
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08725
[Journal Article] Differential protein expression of DARPP-32 versus Calcineurin in the prefrontal cortex and nucleus accumbens in schizophrenia and bipolar disorder2019
- Author(s)
  Kunii Yasuto、Hino Mizuki、Matsumoto Junya、Nagaoka Atsuko、Nawa Hiroyuki、Kakita Akiyoshi、Akatsu Hiroyasu、Hashizume Yoshio、Yabe Hirooki
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Pages: 14877-14877
- DOI
  10.1038/s41598-019-51456-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15522, KAKENHI-PROJECT-17K08725
[Journal Article] Flotillin is a Novel Diagnostic Blood Marker of Alzheimer’s Disease2019
- Author(s)
  Abdullah M, Kimura N, Akatsu H, Hashizume Y, Ferdous T, Tachita T, Iida S, Zou K, Matsubara E, Michikawa M.
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 72 Pages: 1165-1176
- DOI
  10.3233/jad-190908
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07916, KAKENHI-PROJECT-19K17040, KAKENHI-PROJECT-19H03566, KAKENHI-PROJECT-17K08725
[Journal Article] Isotope Corrected Chiral and Achiral Nontargeted Metabolomics: An Approach for High Accuracy and Precision Metabolomics Based on Derivatization and Its Application to Cerebrospinal Fluid of Patients with Alzheimer’s Disease2019
- Author(s)
  Takayama T, Mizuno H, Toyo'oka T, Akatsu H, Inoue K, Todoroki K.
- Journal Title
  
  Analytical Chemistry
  
  Volume: 19(3) Pages: 4396-4404
- DOI
  10.1021/acs.analchem.8b04852
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08725, KAKENHI-PROJECT-16J11918, KAKENHI-PROJECT-16K21276, KAKENHI-PROJECT-19K07028
[Journal Article] Factors influencing hospital admission among patients with autopsy‐confirmed dementia2019
- Author(s)
  Matsuoka T, Manabe T, Akatsu H, Hashizume Y, Yamamoto S, Ogawa N, Kanesaka T, Taniguchi C, Yamamoto T, Mizukami K.
- Journal Title
  
  Psychogeriatrics
  
  Volume: 19(3) Pages: 255-263
- DOI
  10.1111/psyg.12393
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08725
[Journal Article] Serum levels of proteins involved in amyloid-β clearance are related to cognitive decline and neuroimaging changes in mild cognitive impairment.2019
- Author(s)
  Liu S, Suzuki H, Ito H, Korenaga T, Akatsu H, Meno K, Uchida K.
- Journal Title
  
  Alzheimers Dement (Amst).
  
  Volume: Jan 12 Pages: 85-97
- DOI
  10.1016/j.dadm.2018.11.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08725
[Journal Article] Pneumonia-associated death in patients with dementia: A systematic review and meta-analysis2019
- Author(s)
  Manabe Toshie、Fujikura Yuji、Mizukami Katsuyoshi、Akatsu Hiroyasu、Kudo Koichiro
- Journal Title
  
  PLOS ONE
  
  Volume: 14
- DOI
  10.1371/journal.pone.0213825
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08725
[Journal Article] [Effects of drug treatment on the surviral-time in patients with dementia2019
- Author(s)
  Manabe T, Mizukami K, Matsuoka T, Ogawa N, Kanesaka T, Taniguchi C, Yamamoto S, Hashizume Y, Ohara H, Yamamoto T, Akatsu H.
- Journal Title
  
  Nihon Ronen Igakkai Zasshi
  
  Volume: 56(2) Pages: 171-180
- NAID
  130007650185
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08725
[Journal Article] Maternal undernutrition during early pregnancy inhibits postnatal growth of the tibia in the female offspring of rats by alteration of chondrogenesis.2018
- Author(s)
  Kimura T, Hino K, Kono T, Takano A, Nitta N, Ushio N, Hino S, Takase R, Kudo M, Daigo Y, Morita W, Nakao M, Nakatsukasa M, Tamagawa T, Rafiq AM, Matsumoto A, Otani H, Udagawa J.
- Journal Title
  
  Gen Comp Endocrinol.
  
  Volume: 260 Issue: 1 Pages: 58-60
- DOI
  10.1016/j.ygcen.2017.12.008
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08441, KAKENHI-PROJECT-17K01452, KAKENHI-PROJECT-15H04707, KAKENHI-PROJECT-17K07585, KAKENHI-PROJECT-18K19479, KAKENHI-PROJECT-18H02618, KAKENHI-PROJECT-16K07215, KAKENHI-PROJECT-16K08928, KAKENHI-PROJECT-16H06277
[Journal Article] Integrated analysis of human genetic association study and mouse transcriptome suggests LBH and SHF genes as novel susceptible genes for amyloid-β accumulation in Alzheimer's disease2018
- Author(s)
  Yamaguchi-Kabata Y, Morihara T, Ohara T, Ninomiya T, Takahashi A, Akatsu H, Hashizume Y, Hayashi N, Shigemizu D, Boroevich KA, Ikeda M, Kubo M, Takeda M, Tsunoda T.
- Journal Title
  
  Human Genetics
  
  Volume: 37(6-7) Pages: 132-146
- DOI
  10.1007/s00439-018-1906-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08725, KAKENHI-PROJECT-17K10301, KAKENHI-PROJECT-18K07565, KAKENHI-PLANNED-17H06307, KAKENHI-PROJECT-16H05379, KAKENHI-PROJECT-18H03121
[Journal Article] The prospective association between plasma concentrations of cellular growth factors and risk of heart failure mortality in Japanese population.2018
- Author(s)
  Ehab S Eshak, Koutatsu Maruyama, Hiroyasu Iso, Akiko Tamakoshi.
- Journal Title
  
  J of Epidemiology
- NAID
  130007607770
- Description
  in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06277
[Journal Article] Complement activation in capillary cerebral amyloid angiopathy.2018
- Author(s)
  Matsuo K, Shindo A, Niwa A, Tabei KI, Akatsu H, Hashizume Y, Akiyama H, Ayaki T, Maki T, Sawamoto N, Takahashi R, Oikawa S, Tomimoto H.
- Journal Title
  
  Dement Geriatr Cogn Disord.
  
  Volume: 44 Pages: 343-343
- DOI
  10.1159/000486091
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08725, KAKENHI-PROJECT-15K15237, KAKENHI-PROJECT-16K15246, KAKENHI-PROJECT-17K17811, KAKENHI-PROJECT-25870325, KAKENHI-PROJECT-16H06277
[Journal Article] TDP-43 and DISC1 Co-Aggregation Disrupts Dendritic Local Translation and Mental Function in FTLD.2018
- Author(s)
  Endo, R., Takashima, N., Nekooki-Machida, Y., Komi, Y., Hui, K. K., Takao, M., Akatsu, H., Murayama, S., Sawa, A., and Tanaka, M.
- Journal Title
  
  Biol. Psychiatry
  
  Volume: 84(7) Pages: 509-521
- DOI
  10.1016/j.biopsych.2018.03.008
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08725, KAKENHI-PROJECT-17K19468, KAKENHI-PLANNED-26116004, KAKENHI-PROJECT-16H06277
[Journal Article] Targeting tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology.2018
- Author(s)
  Fujita K, Chen X, Homma H, Tagawa K, Amano M, Saito A, Imoto S, Akatsu H, Hashizume Y, Kaibuchi K, Miyano S, Okazawa H.
- Journal Title
  
  Nat Commun.
  
  Volume: 9 Issue: 1 Pages: 433-433
- DOI
  10.1038/s41467-018-02821-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07383, KAKENHI-PROJECT-17K08725, KAKENHI-PLANNED-15H05912, KAKENHI-PUBLICLY-17H05561, KAKENHI-PUBLICLY-17H05693, KAKENHI-PROJECT-16H02655, KAKENHI-PROJECT-16H06277
[Journal Article] Fluorine-19 magnetic resonance imaging probe for the detection of tau pathology in female rTg4510 mice.2018
- Author(s)
  Yanagisawa Daijiro、Ibrahim Nor Faeizah、Taguchi Hiroyasu、Morikawa Shigehiro、Kato Tomoko、Hirao Koichi、Shirai Nobuaki、Sogabe Takayuki、Tooyama Ikuo
- Journal Title
  
  Journal of Neuroscience Rsearch
  
  Volume: 96 Pages: 841-851
- DOI
  10.1002/jnr.24188
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01355, KAKENHI-PROJECT-17K01563, KAKENHI-PROJECT-26282145, KAKENHI-PROJECT-17H03560, KAKENHI-PROJECT-15K01282
[Journal Article] Lysophosphatidylcholine export by human ABCA7.2017
- Author(s)
  Tomioka M, Toda Y, Manucat NB, Akatsu H, Fukumoto M, Kono N, Arai H, Kioka N, Ueda K.
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
  
  Volume: 印刷中 Issue: 7 Pages: 658-665
- DOI
  10.1016/j.bbalip.2017.03.012
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221203, KAKENHI-PROJECT-16K15090, KAKENHI-PROJECT-16K15571, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-17H06164
[Journal Article] 高精度キラルメタボロミクスの開発とアルツハイマー患者分析への応用2017
- Author(s)
  高山卓大、水野初、豊岡利正、井之上浩一、赤津裕康、轟木堅一郎
- Journal Title
  
  JSBMS Letters
  
  Volume: 42 Issue: 2 Pages: 39-40
- Data Source
  KAKENHI-PROJECT-16H06277
[Journal Article] ヒト, マウス組織におけるABCA1, ABCA7蛋白の作用機構の解析2017
- Author(s)
  戸田好信、赤津裕康、植田和光
- Journal Title
  
  臨床病理
  
  Volume: 65 Pages: 183-183
- Data Source
  KAKENHI-PROJECT-16H06277
[Journal Article] A novel diagnostic marker for Alzheimer's disease2017
- Author(s)
  アブドラ・モハンマド, 木村成志, 赤津裕康, 橋詰良夫, フェルドス・タスリマ, 松原悦朗, 道川誠
- Journal Title
  
  Dementia Japan
  
  Volume: 31 Issue: 4 Pages: 612-612
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06277
[Journal Article] Deficiency of a sulfotransferase for sialic acid-modified glycans mitigates Alzheimer's pathology.2017
- Author(s)
  Zhang Z, Takeda-Uchimura Y, Foyez T, Ohtake-Niimi S, Narentuya, Akatsu H, Nishitsuji K, Michikawa M, Wyss-Coray T, Kadomatsu K, Uchimura K.
- Journal Title
  
  Proc Nat1 Acad Sci U S A.
  
  Volume: 114(14) Pages: 114-114
- DOI
  10.1073/pnas.1615036114
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-WRAPUP-16H01694, KAKENHI-PROJECT-16H05559, KAKENHI-PROJECT-15K15079, KAKENHI-PROJECT-17K16123, KAKENHI-PROJECT-16H05139, KAKENHI-PROJECT-15K15712, KAKENHI-PROJECT-16H06277
[Journal Article] LC-HR/MSによるアルツハイマー病患者脳脊髄液のキラルメタボロミクス2017
- Author(s)
  高山卓大、水野初、井之上浩一、赤津裕康、豊岡利正、轟木堅一郎
- Journal Title
  
  JSBMS Letters
  
  Volume: 42 Pages: 106-106
- Data Source
  KAKENHI-PROJECT-16H06277
[Journal Article] Downregulation of GNA13-ERK network in prefrontal cortex of schizophrenia brain identified by combined focused and targeted quantitative proteomics.2017
- Author(s)
  Hirayama-Kurogi M, Takizawa Y, Kunii Y, Matsumoto J, Wada A, Hino M, Akatsu H, Hashizume Y, Yamamoto S, Kondo T, Ito S, Tachikawa M, Niwa SI, Yabe H, Terasaki T, Setou M, Ohtsuki S.
- Journal Title
  
  J Proteomics.
  
  Volume: 158 Pages: 31-42
- DOI
  10.1016/j.jprot.2017.02.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-14J05334, KAKENHI-PROJECT-16H06277
[Journal Article] Decreased 16:0/20:4-phosphatidylinositol level in the post-mortem prefrontal cortex of elderly patients with schizophrenia2017
- Author(s)
  Matsumoto J, Nakanishi H, Kunii Y, Sugiura Y, Yuki D, Wada A, Hino M, Niwa SI, Kondo T, Waki M, Hayasaka T, Masaki N, Akatsu H, Hashizume Y, Yamamoto S, Sato S, Sasaki T, Setou M, Yabe H
- Journal Title
  
  Sci Rep
  
  Volume: 7 Issue: 7 Pages: 1-11
- DOI
  10.1038/srep45050
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05898, KAKENHI-PROJECT-15H04693, KAKENHI-PROJECT-16H06145, KAKENHI-PROJECT-14J05334, KAKENHI-PROJECT-15K14947, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-26670132, KAKENHI-PROJECT-15K18857, KAKENHI-PROJECT-15K08608, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-26253006, KAKENHI-PLANNED-15H05899
[Journal Article] Increase in α-tubulin modifications in the neuronal processes of hippocampal neurons in both kainic acid-induced epileptic seizure and Alzheimer's disease2017
- Author(s)
  Vu HT, Akatsu H, Hashizume Y, Setou M, Ikegami K.
- Journal Title
  
  Sci Rep
  
  Volume: 7 Pages: 40205-40205
- DOI
  10.1038/srep40205
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06277
[Journal Article] Comparative analysis of cortical microinfarcts and microbleeds using 3.0-tesla postmortem magnetic resonance images and histopathology.2017
- Author(s)
  Niwa A, Ii Y, Shindo A, Matsuo K, Ishikawa H, Taniguchi A, Takase S, Maeda M, Sakuma H, Akatsu H, Hashizume Y, Tomimoto H
- Journal Title
  
  J Alzheimers Dis.
  
  Volume: 59 Issue: 3 Pages: 951-951
- DOI
  10.3233/jad-161242
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10315, KAKENHI-PROJECT-17K08725, KAKENHI-PROJECT-16K15246, KAKENHI-PROJECT-16H06277
[Journal Article] Factors associated with pneumonia-caused death in older adults with autopsy-confirmed dementia.2017
- Author(s)
  Manabe T, Mizukami K, Akatsu H, Hashizume Y, Ohkubo T, Kudo K, Hizawa N
- Journal Title
  
  Internal Medicine
  
  Volume: 56(8) Issue: 8 Pages: 907-914
- DOI
  10.2169/internalmedicine.56.7879
- NAID
  130006857581
- ISSN
  0918-2918, 1349-7235
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08725, KAKENHI-PROJECT-16H06277
[Journal Article] Histopathology and florbetaben PET in patients incorrectly diagnosed with Alzheimer's disease.2017
- Author(s)
  Sabbagh MN, Schauble B, Anand K, Richards D, Murayama S, Akatsu H, Takao M, Rowe CC, Masters CL, Barthel H, Gertz HJ, Peters O, Rasgon N, Jovalekic A, Sabri O, Schulz-Schaeffer WJ and Seibyl J
- Journal Title
  
  J Alzheimers Dis.
  
  Volume: 56 Issue: 2 Pages: 441-446
- DOI
  10.3233/jad-160821
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06277
[Journal Article] LC-MS/MSを用いたヒト脳脊髄液中におけるアルツハイマー病の新規バイオマーカー探索2017
- Author(s)
  野田巧、六車宜央、筒井陽仁、赤津裕康、井之上浩一
- Journal Title
  
  JSBMS Letters.
  
  Volume: 42 Pages: 76-76
- Data Source
  KAKENHI-PROJECT-16H06277
[Journal Article] Mass spectrometric analysis of accumulated TDP-43 in amyotrophic lateral sclerosis brains.2016
- Author(s)
  Kametani F, Obi T, Shishido T, Akatsu H, Murayama S, Saito Y, Yoshida M, Hasegawa M
- Journal Title
  
  Scientific Reports
  
  Volume: － Pages: 23281-23281
- DOI
  10.1038/srep23281
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-23228004, KAKENHI-PROJECT-25461777, KAKENHI-PROJECT-16H06277
[Journal Article] Impact of Training Method on the Robustness of the Visual Assessment of 18F-Florbetaben PET Scans : Results from a Phase-3 Study.2016
- Author(s)
  Seibyl J, Ishii K, Rowe CC, Leverenz JB, Ghetti B, Ironside JW, Takao M, Akatsu H, Murayama S, Bullich S, Mueller A, Koglin N, Schulz-Schaeffer WJ, Hoffmann A, Sabbagh MN, et. al
- Journal Title
  
  J Nucl Med
  
  Volume: 57 Pages: 900-906
- DOI
  10.2967/jnumed.115.161927
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06277
[Journal Article] A novel approach for LC-MS/MS-based chiral metabolomics fingerprinting and chiral metabolomics extraction using a pair of enantiomers of chiral derivatization reagents.2015
- Author(s)
  Takahiro Takayama, Toshiki Mochizuki, Kenichiro Todoroki, Jun Zhe Min,Hajime Mizuno, Koichi Inoue, Hiroyasu Akatsu, Ichiro Noge, Toshimasa Toyo'oka
- Journal Title
  
  Anal Chim Acta
  
  Volume: 898 Pages: 73-84
- DOI
  10.1016/j.aca.2015.10.010
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K07895, KAKENHI-PROJECT-25460040, KAKENHI-PROJECT-25461777
[Journal Article] Alpha1-chimaerin, a Rac1 GTPase-activating protein, is expressed at reduced mRNA levels in the brain of Alzheimer's disease patients.2015
- Author(s)
  Kato T, Konishi Y, Shimohama S, Beach TG, Akatsu H, Tooyama I
- Journal Title
  
  Neurosci Letters
  
  Volume: ５９０１ Pages: 19-24
- DOI
  10.1016/j.neulet.2015.02.013
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24500431, KAKENHI-PROJECT-26290022, KAKENHI-PUBLICLY-26111709
[Journal Article] Increased production of intestinal immunoglobulins in Syntenin-1-deficient mice.2015
- Author(s)
  Tamura K., Ikutani M., Yoshida T., Tanaka-Hayashi A., Yanagibashi T., Inoue R., Nagai Y., Adachi Y., Miyawaki T., Takatsu K., Mori H.
- Journal Title
  
  Immunobiology
  
  Volume: 220 Pages: 597-604
- DOI
  10.1016/j.imbio.2014.12.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390119, KAKENHI-PROJECT-24590577, KAKENHI-PUBLICLY-25126707, KAKENHI-PROJECT-221S0003
[Journal Article] Blood-based diagnosis of Alzheimer's disease using fingerprinting metabolomic based on hydrophilic interaction liquid chromatography with mass spectrometry and multivariate stastitical analysis2015
- Author(s)
  Koichi Inoue, Hirofumi Tsuchiya, Takahiro Takayama, Hiroyasu Akatsu,Yoshio Hashizume, Takayuki Yamamoto, Noriyuki Matsukawa, Toshimasa Toyo'oka
- Journal Title
  
  J Chromatogr B Analyt Technol Biomed Life Sci
  
  Volume: 974 Pages: 24-34
- DOI
  10.1016/j.jchromb.2014.10.022
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590055, KAKENHI-PROJECT-24590061, KAKENHI-PROJECT-25461777
[Journal Article] Blood-based diagnosis of Alzheimer's disease using fingerprinting metabolomics based on hydrophilic interaction liquid chromatography with mass spectrometry and multivariate statistical analysis.2015
- Author(s)
  Inoue K, Tsuchiya H, Takayama T, Akatsu H, Hashizume Y, Yamamoto T, Matsukawa N, Toyo'oka T.
- Journal Title
  
  J Chromatogr B Analyt Technol Biomed Life Sci.
  
  Volume: ９７４ Pages: 24-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500431
[Journal Article] Structural Basis for Gating Mechanisms of a Eukaryotic P-glycoprotein Homolog.2014
- Author(s)
  Atsushi Kodan, Tomohiro Yamaguchi, Toru Nakatsu, Keita Sakiyama, Christopher Hipolito, Akane Fujioka, Ryo Hirokane, Keiji Ikeguchi, Bunta Watanabe, Jun Hiratake, Yasuhisa Kimura, Hiroaki Suga, Kazumitsu Ueda, Hiroaki Kato
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 111 Pages: 4049-4054
- DOI
  10.1073/pnas.1321562111
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24659018, KAKENHI-PROJECT-24689029, KAKENHI-PROJECT-25221203, KAKENHI-PROJECT-25251006
[Journal Article] Distinction between mild cognitive impairment and Alzheimer's disease2014
- Author(s)
  Mizoi, M. et al.
- Journal Title
  
  Clin Chim Acta
  
  Volume: 430 Pages: 150-155
- DOI
  10.1016/j.cca.2014.01.007
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23390038, KAKENHI-PROJECT-23590088, KAKENHI-PROJECT-24500431, KAKENHI-PROJECT-24591695
[Journal Article] Simultaneous determination of post-translational racemization and isomerization of N-terminal amyloid-β in Alzheimer's brain tissue by covalent chiral derivatized ultraperformance liquid chromatography tandem mass spectrometry2014
- Author(s)
  Inoue K, Hosaka D, Mochizuki N, Akatsu H, Tsutsumiuchi K, Hashizume Y, Matsukawa N, Yamamoto T, Toyo'oka T
- Journal Title
  
  Anal Chem
  
  Volume: 86(1) Pages: 797-804
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461777
[Journal Article] Simultaneous determination of post-translational racemization and isomerization of N-terminal amyloid-β in Alzheimer’s brain tissues by covalent chiral derivatized ultra-performance liquid chromatography tandem mass spectrometry2014
- Author(s)
  Inoue K, Hosaka D, Mochizuki N, Akatsu H, Tsutsumiuchi K, Hashizume Y, Matsukawa N, Yamamoto T, Toyo'oka T.
- Journal Title
  
  Analytical Chemistry
  
  Volume: ８６ Pages: 797-804
- DOI
  10.1021/ac403315h
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24500431, KAKENHI-PROJECT-24590055
[Journal Article] A Chemical Probe That Labels Human Pluripotent Stem Cells.2014
- Author(s)
  Hirata N, Nakagawa M, Fujibayashi Y, Yamauchi K, Murata A, Minami I, Tomioka M, Kondo T, Kuo TF, Endo H, Inoue H, Sato S, Ando S, Kawazoe Y, Aiba K, Nagata K, Kawase E, Chang YT, Suemori H, Eto K, Nakauchi H, Yamanaka S, Nakatsuji N, Ueda K, Uesugi M
- Journal Title
  
  Cell Rep
  
  Volume: 6 Pages: 1165-1174
- DOI
  10.1016/j.celrep.2014.02.006
- NAID
  120005466668
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23106004, KAKENHI-PROJECT-23500446, KAKENHI-PROJECT-23510277, KAKENHI-PROJECT-24249056, KAKENHI-PROJECT-24510316, KAKENHI-PROJECT-24590353, KAKENHI-PROJECT-24615003, KAKENHI-PROJECT-25221203, KAKENHI-PROJECT-25560195, KAKENHI-PUBLICLY-26102728, KAKENHI-PROJECT-26220206, KAKENHI-PROJECT-26560445
[Journal Article] Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid beta accumulation modifier.2014
- Author(s)
  Morihara, T., Hayashi, N., Yokokoji, M., Akatsu, H., Silverman, MA., Kimura, N., Saito, Y., Suzuki, T., Yanagida, K., Tanaka, T., Kazui, H., Kudo, T., Kodama, TS., Sato, M., Hashimoto, R., Tagami, S., Okochi, M., Ytoh, N., Nishitomi, K., Takamura, H., Katayama, T., Hashizumi, Y., Kimura, R., Kamino, K., Takeda, M
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 111 Pages: 26382643-26382643
- DOI
  10.1073/pnas.1307345111
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23390017, KAKENHI-PROJECT-23591703, KAKENHI-PROJECT-23791332, KAKENHI-PROJECT-24591708, KAKENHI-PROJECT-24591709, KAKENHI-PROJECT-25290039, KAKENHI-PROJECT-25293250, KAKENHI-PROJECT-25461768, KAKENHI-PROJECT-26293010, KAKENHI-PROJECT-26461746, KAKENHI-PROJECT-26461747
[Journal Article] Increased levels of plasma p3-Alc alpha35, a major fragment of Alcadein alpha by gamma-secretase cleavage, in Alzheimer's disease2014
- Author(s)
  Omori C, Kaneko M, Nakajima E, Akatsu H, Waragai M, Maeda M, Moroshima-Kawashima M, Saito Y, Nakaya T, Taru H, Yamamoto T, Asada T, Hata S, Suzuki T. for J-ADNI
- Journal Title
  
  J. Alzheimers Dis.
  
  Volume: 39 Pages: 861-70
- DOI
  10.3233/jad-131610
- NAID
  120005460251
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23390017, KAKENHI-PROJECT-24500431, KAKENHI-PROJECT-24500433, KAKENHI-PROJECT-24591695, KAKENHI-PROJECT-24790062, KAKENHI-PROJECT-25460058, KAKENHI-PROJECT-25460059, KAKENHI-PROJECT-26293010
[Journal Article] Development of a method to measure Aβ42 in nasal cavity samples and its appilication in normal human volunteers.2014
- Author(s)
  Nanjo T, Fukuhara T, Kameshima N, Yanagisawa D, Shimizu S, Shimizu T, Shiino A, Akatsu H, Yamamotyo T, Tooyama I
- Journal Title
  
  Journal of Brain Science
  
  Volume: 4 Pages: 5-23
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26640042
[Journal Article] Selective Elimination of Human Pluripotent Stem Cells by a Marine Natural Product Derivative.2014
- Author(s)
  Ting-Fang Kuo, Di Mao, Nao Hirata, Bilon Khambu, Yasuhisa Kimura, Eihachiro Kawase, Hiroki Shimogawa, Makoto Ojika, Norio Nakatsuji, Kazumitsu Ueda, and Motonari Uesugi
- Journal Title
  
  J. Am. Chem. Soc.
  
  Volume: 136 Pages: 9798-9801
- DOI
  10.1021/ja501795c
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25221203, KAKENHI-PROJECT-25560195, KAKENHI-PUBLICLY-26102728, KAKENHI-PROJECT-26220206, KAKENHI-PROJECT-26560445
[Journal Article] Lack of Genetic Association Between TREM2 and Late-Onset Alzheimer's Disease in a Japanese Population.2014
- Author(s)
  Akinori Miyashitaa, Yanan Wen　他
- Journal Title
  
  J Alzheimers Dis.
  
  Volume: 印刷中 Pages: 1031-1038
- DOI
  10.3233/jad-140225
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-22129004, KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-23591231, KAKENHI-PROJECT-24310144, KAKENHI-PROJECT-24390179, KAKENHI-PROJECT-24500431, KAKENHI-PROJECT-24700371, KAKENHI-PROJECT-25670415, KAKENHI-PROJECT-26460907, KAKENHI-PROJECT-26461264
[Journal Article] Transition metal abnormalities in progressive dementias.2012
- Author(s)
  Akatsu H
- Journal Title
  
  Biometals
  
  Volume: Apr;25(2) Pages: 337-350
- DOI
  10.1007/s10534-011-9504-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500431
[Journal Article] Multiple findings in elderly adults with confirmed Alzheimer's disease.2012
- Author(s)
  Akatsu H
- Journal Title
  
  J Am Geriatr Soc.
  
  Volume: Nov;60(11) Pages: 2169-2170
- DOI
  10.1111/j.1532-5415.2012.04224.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500431
[Journal Article] SORL1 is genetically associated with Alzheimer disease in a Japanese population2009
- Author(s)
  Kimura R, Yamamoto M, Morihara T, Akatsu H, Kudo T, Kamino K, Takeda M.
- Journal Title
  
  Neurosci Lett 461(2):
  
  Pages: 177-180
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019043
[Journal Article] Analysis of DNA variations in promoter region of HCNP gene with Alzheimer's disease2009
- Author(s)
  Okita K, Matsukawa N, Maki M, Nakazawa H, Katada E, Hattori M, Akatsu H, Borlongan CV, Ojika K.
- Journal Title
  
  Biochem Biophys Res Commun 379(2)
  
  Pages: 272-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019043
[Journal Article] Analysis of DNA variations in promoter region of HCNP gene with Alzheimer's disease.2009
- Author(s)
  Okita K, Matsukawa N, Maki M, Nakazawa H, Katada E, Hattori M, Akatsu H, Borlongan CV, Ojika K.
- Journal Title
  
  Biochem Biophys Res Commun. 379(2)
  
  Pages: 272-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019043
[Journal Article] Sugar chains of cerebrospinal fluid transferrin as a new biological marker of Alzheimer's disease2008
- Author(s)
  Taniguchi M, Okayama Y, Hashimoto Y, Kitaura M, Jimbo D, Wakutani Y, Wada-Isoe K, Nakashima K, Akatsu H, Furukawa K. Arai H. Urakami K.
- Journal Title
  
  Dement Geriatr Cogn Disord 26(2)
  
  Pages: 117-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019043
[Journal Article] Sugar chains of cerebrospinal fluid transferrin as a new biological marker of Alzheimer's disease.2008
- Author(s)
  Taniguchi, M., Okayama, Y., Hashimoto, Y., Kitaura, M., Jimbo, D., Wakutani, Y., Wada-Isoe, K., Nakashima, K., Akatsu, H., Furukawa, K., Arai, H., Urakami, K. Dement
- Journal Title
  
  Geriatr Cogn Disord. 26(2)
  
  Pages: 117-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019043
[Journal Article] The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease.2007
- Author(s)
  Kimura, R・Kamino, K・Yamamoto, M・Nuripa, A・Kida, T・Kazui, H・Hasimoto, R・Tanaka, T・Kudo, T・Yamatata, H・Tabara, Y・Miki, T・Akatsu, H・Kosada, K・Funakoshi, E・Nishitomi, K・Sakaguchi, G・Kato, A・Hattori, H・Uema, T・Takeda, M.
- Journal Title
  
  Hum Mol Genet. 16
  
  Pages: 15-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019043
[Journal Article] The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between β amyloid production and tau phosphorylation in Alzheimer disease.2007
- Author(s)
  Kimura R, Kamino K, Yamamoto M, Nuripa A, Kida T, Kazui H, Hashimoto R, Tanaka T, Kudo T, Yamagata H, Tabara Y, Miki T, Akatsu H, Kosaka K, Funakoshi E, Nishitomi K, Sakaguchi G, Kato A, Hattori H, Uema T, Takeda M.
- Journal Title
  
  Human Molecular Genetics 16
  
  Pages: 15-23
- Data Source
  KAKENHI-PROJECT-17019043
[Journal Article] Expression of alpha-synuclein, a presynaptic protein implicated in Parkinson's disease, in erythropoietic lineage.2007
- Author(s)
  Nakai M, Fujita M, Waragai M, Sugama S, Wei J, Akatsu H, Ohtaka-Maruyama C, Okado H, Hashimoto M.
- Journal Title
  
  Biochem Biophys Res Commun. 358(1)
  
  Pages: 104-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019043
[Journal Article] Reduced Neuron-Specific Expression of the TAF1 Gene Is Ass ociated with X-Linked Dystonia-Parkinsonism.2007
- Author(s)
  Makino, S・Kaji, R・Ando, S・Tomizawa, M・Yasuno, K・Goto, S・Matsumoto, S・Tabuena, MD・Maranon, E・Dantes, M・Lee, LV・Ogasawara, K・Tooyama, I・Akatsu, H・Nishimura, M・Tamiya, G
- Journal Title
  
  Am J.Hum Genet. 80
  
  Pages: 393-406
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019043
[Journal Article] A novel alternative splice variant of nicastrin and its implication in Alzheimer diseaseMitsuda, N., Yamagata, HD., Zhong, W.2006
- Author(s)
  Akatsu, H., Uekawa, N., Kamino, K., Taguchi, K., Yamamoto, T., Maruyama, M., Kosaka, K., et al.
- Journal Title
  
  Life Sciences 78(21)
  
  Pages: 2444-2448
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019043
[Journal Article] A novel alternative splice variant of nicastrin and its implication in Alzheimer disease.2006
- Author(s)
  Mitsuda N, Yamagata HD, Zhong W, Aoto M, Akatsu H, Uekawa N, Kamino K, Taguchi K, Yamamoto T, Maruyama M, Kosaka K, Takeda M, Kondo I, Miki T
- Journal Title
  
  Life Sciences 78
  
  Pages: 2444-2448
- Data Source
  KAKENHI-PROJECT-17019043
[Journal Article] Albumin gene encoding FFA and beta amyloid transporter is a risk gen for Alzheimer disease.2006
- Author(s)
  Kimura R, Kamino K, Yamamoto M, Akatsu H, Uema T, Kobayashi T, Hattori H, Nuripa A, Nessa B, Kudo T, Yamagata H, miki T, Takeda M.
- Journal Title
  
  Psychiatry and Clinical Neuroscience (In press)
- Data Source
  KAKENHI-PROJECT-17019043
[Journal Article] Albumin gene encoding free fatty acid and β-amyloid transporter is genetically associated with Alzheimer disease.2006
- Author(s)
  Kimura R, Kamino K, Yamamoto M, Akatsu H, Uema T, Kobayashi T, Hattori H, Nuripa A, Nessa B, Kudo T, Yamagata H, miki T, Takeda M.
- Journal Title
  
  Psychiatry and Clinical Neuroscience 60
- Data Source
  KAKENHI-PROJECT-17019043
[Journal Article] Variations in the BDNF gene in autopsy-confirmed Alzheimer's disease and dementia with Lewy bodies in Japan.2006
- Author(s)
  Akatsu H, Yamagata H, Kawamata J, Kamino K, Takeda M, Yamamoto T, Miki T, Tooyama I, Shimohama S, Kosaka K, Okada H.
- Journal Title
  
  Dementia and Geriatric Cognitive Disorders 22
  
  Pages: 216-222
- NAID
  40015443844
- Data Source
  KAKENHI-PROJECT-17019043
[Journal Article] Albumin gene encoding FFA and beta amyloid transporter is a risk gene for Alzheimer disease.2006
- Author(s)
  Kimura, R., Kamino, K., Yamamoto, M., Akatsu, H., Uema, T., Kobayashi, T., Hattori, H., Nuripa, A., Nessa, B., Kudo, T., et al.
- Journal Title
  
  Psyichiat Clin Neurosci 60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019043
[Journal Article] Depletion of cholinergic neurons in nucleus of the medial septum and the vertical limb of the diagonal band in dementia with Lewy bodies.2006
- Author(s)
  Fujishiro H, Umegaki H, Isojima D, Akatsu H, Iguchi A, Kosaka K
- Journal Title
  
  Acta Neuropathol 111(2)
  
  Pages: 109-114
- NAID
  40015443843
- Data Source
  KAKENHI-PROJECT-17591207
[Journal Article] Lib, transcriptionally induced in senile plaque-associated astrocytes, promotes glial migration through extracellular matrix.2005
- Author(s)
  Satoh K, Hata M, Shimizu T, Yokota H, Akatsu H, Yamamoto T, Kosaka K, Yamada T.
- Journal Title
  
  Biochem Biophys Res Commun. 335(2)
  
  Pages: 631-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019043
[Journal Article] Identification of hippocampus-related candidate genes for Alzheimer's disease.2005
- Author(s)
  Taguchi K, Yamagata H, Zhong W, Kamino K, Akatsu H, Hata R, Yamamoto T, Kosaka K, Takeda M, Kondo I, Miki T.
- Journal Title
  
  Ann Neurol 57(4)
  
  Pages: 585-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019043
[Journal Article] Identification of hippocampus-related candidate genes for Alzheimer's disease.2005
- Author(s)
  Taguchi K, Yamagata H, Zhong W, Kamino K, Akatsu H, Hata R, Yamamoto T, Kosaka K, Takeda M, Kondo I, Miki T.
- Journal Title
  
  Annals of Neurology 57・4
  
  Pages: 585-588
- Data Source
  KAKENHI-PROJECT-17019043
[Journal Article] Increased incidence of dementia with Lewy bodies in patients carrying the e4-allele of apolipoprotein E.2004
- Author(s)
  Akatsu H, Kamino K, Yamagata H, Isojima D, Kondo I, Yamamoto T, Kida T, Takeda M, Miki T, Kosaka K.
- Journal Title
  
  PSYCHOGERIATRICS 4
  
  Pages: 23-32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019043
[Journal Article] Pathological entity of dementia with Lewy bodies and its differentiation from Alzheimer's disease.2004
- Author(s)
  Marui W, Iseki E, Kato M, Akatsu H, Kosaka K.
- Journal Title
  
  Acta Neuropathol. 108(2)
  
  Pages: 121-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019043
[Journal Article] Promoter polymorphism in fibroblast growth factor 1 gene increases risk of definite Alzheimer's disease.2004
- Author(s)
  Yamagata H, Chen Y, Akatsu H, Kamino K, Ito J, Yokoyama S, Yamamoto T, Kosaka K, Miki T, Kondo I.
- Journal Title
  
  Biochem Biophys Res Commun 321
  
  Pages: 320-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019043
[Journal Article] TAFI polymorphisms at amino acids 147 and 325 are not risk factors for cerebral infarction.2004
- Author(s)
  Akatsu H, Yamagata H, Chen Y, Miki T, Kamino K, Takeda M, Campbell W, Kondo I, Kosaka K, Yamamoto T, Okada H.
- Journal Title
  
  British J Haematology 127
  
  Pages: 440-447
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019043
[Patent] 転倒予防システム2019
- Inventor(s)
  赤津裕康、森啓悟、加藤周平
- Industrial Property Rights Holder
  赤津裕康、森啓悟、加藤周平
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-117877
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-17K08725
[Patent] アルツハイマー病バイオマーカー2018
- Inventor(s)
  道川誠、赤津裕康、アブドラモハンマド、松原悦朗、木村成志
- Industrial Property Rights Holder
  道川誠、赤津裕康、アブドラモハンマド、松原悦朗、木村成志
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Overseas
- Data Source
  KAKENHI-PROJECT-16H05559
[Patent] AD診断技術2017
- Inventor(s)
  吉宗一晃、赤津裕康、神野英毅
- Industrial Property Rights Holder
  吉宗一晃、赤津裕康、神野英毅
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-045244
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-16H06277
[Presentation] 15)神経病理学診断による認知症高齢者の生命予後期間に関するBPSDの影響について2019
- Author(s)
  松岡珠美、間辺利江、赤津裕康、橋詰良夫、水上勝義
- Organizer
  第31回日本老年医学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08725
[Presentation] Therapeutic effects of a curcumin derivative Shiga-Y5 in the brain of a mouse model of Alzheimer’s disease2019
- Author(s)
  Daijiro Yanagisawa, Hiroyasu Taguchi, Ikuo Tooyama
- Organizer
  第13回日中合同組織細胞化学セミナー
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03560
[Presentation] How risky of intravenous iron administration?2019
- Author(s)
  Hiroyasu Akatsu,Yoshihiro Kawade, et al
- Organizer
  41ｔｈ　ESPEN(欧州静脈経腸栄養学会)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08725
[Presentation] 地域在住高齢者の身体フレイルに及ぼす影響因子の検討2019
- Author(s)
  赤津裕康、川出義弘名古屋市立大学地域医療教育学田中創始、荒川和幸、兼松孝好、大原弘隆帝京大学医学部衛生学公衆衛生学講座間辺利江、足助病院　正木克由規、早川富博
- Organizer
  第31回日本老年医学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08725
[Presentation] Effect of genetic background on tau accumulation in rTg4510 mice2019
- Author(s)
  Daijiro Yanagisawa, Hamizah Shahirah Hamezah, Aslina Pahrudin Arrozi, Hiroyasu Taguchi, Ikuo Tooyama
- Organizer
  Neuro2019
- Data Source
  KAKENHI-PROJECT-17H03560
[Presentation] 認知症の予防検証と薬物療法(薬剤選択)　　　～名市大病院と名古屋市の取り組み～2019
- Author(s)
  赤津裕康
- Organizer
  第61回　全日本病院学会　in 愛知
- Invited
- Data Source
  KAKENHI-PROJECT-17K08725
[Presentation] 精神科病院からの紹介転院を契機に診断されたMM2-視床型孤発性クロイツフェルト・ヤコブ病の剖検例2018
- Author(s)
  兼松孝好、林　紘太郎、荒川和幸、田中創始、赤津裕康、大原弘隆
- Organizer
  第10回　日本神経病理学会　東海・北陸地方会
- Data Source
  KAKENHI-PROJECT-17K08725
[Presentation] アルツハイマー型認知症の病理診断に基づく脳脊髄液・血液ペアのワイドターゲットメタボロミクス解析2018
- Author(s)
  六車宜央, 筒井陽仁, 赤津裕康, 井之上浩一
- Organizer
  第31回バイオメディカル分析科学シンポジウム　教育講演
- Data Source
  KAKENHI-PROJECT-17K08725
[Presentation] TDP-43 and DISC1 Co-Aggregation Disrupts Dendritic Local Translation and Mental Function in FTLD2018
- Author(s)
  Endo, R., Takashima, N., Nekooki-Machida, Y., Komi, Y., Hui, K. K., Takao, M., Akatsu, H., Murayama, S., Sawa, A., and Tanaka, M.
- Organizer
  第18回日本蛋白質科学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-16H06277
[Presentation] 長期経静脈鉄剤投与剖検症例での肝臓鉄沈着、死後血液鉄関連因子の関連性の検討2018
- Author(s)
  赤津裕康、川出義浩、間辺利江、井上風吹、井村尚斗、日比英志、荒川和幸、正木克由規、田中創始、兼松孝好、橋詰良夫、常山幸一、大原弘隆
- Organizer
  第４２回　日本鉄バイオサイエンス学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08725
[Presentation] アルツハイマー病患者試料の高精度キラルメタボロミクスによるマーカー探索2018
- Author(s)
  高山卓大1,2・水野初1・豊岡利正1・赤津裕康3,4・井之上浩一5・轟木堅一郎1
- Organizer
  日本質量分析学会・日本プロテオーム学会2018年合同大会
- Data Source
  KAKENHI-PROJECT-17K08725
[Presentation] Detection of abnormal protein accumulation in Alzheimer’s disease using magnetic resonance imaging.2018
- Author(s)
  Daijiro Yanagisawa, Hiroyasu Taguchi, Ikuo Tooyama
- Organizer
  The 5th Annual Meeting of Mongolian Neuroscience Society
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03560
[Presentation] フッ素MRIによる脳内タウ凝集体の検出2018
- Author(s)
  Daijiro Yanagisawa, Hiroyasu Taguchi, Shigehiro Morikawa, Tomoko Kato, Ikuo Tooyama
- Organizer
  第41回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-17H03560
[Presentation] Dietary intakes of fat soluble vitamins and risk of type 2 diabetes mellitus.2018
- Author(s)
  Ehab S. Eshak, Hiroyasu Iso, Akiko Tamakoshi
- Organizer
  American Society For Nutrition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06277
[Presentation] Fukushimura Brain Bank;Unique activity of Japanese private geriatric hospital2018
- Author(s)
  Hiroyasu Akatsu 1,2), Norihiro Ogawa1), Takeshi Kanesaka1), Chie Taniguchi1), Sakon Yamamoto1), Takayuki Yamamoto, Masaki Takao, Shigeo Murayama, Yoshio Hashizume
- Organizer
  ICN2018TOKYO 19th International Congress of Neuropathology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08725
[Presentation] Curcumin derivative with C-4 substituent attenuated amyloid deposition, but did not affect tau pathology in mouse models.2018
- Author(s)
  Daijiro Yanagisawa, Hiroyasu Taguchi, Lina Wati Durani, Hamizah Shahirah, Hamezah, Ikuo Tooyama
- Organizer
  Alzheimer’s Association International Conference 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03560
[Presentation] Application of double MR imaging for analysis of multiple pathological proteins in the brain of transgenic mouse model of Alzheimer’s disease2017
- Author(s)
  kuo Tooyama, Daijiro Yanagisawa, Hiroyasu Taguchi
- Organizer
  第44回日本脳科学会総会
- Data Source
  KAKENHI-PROJECT-17H03560
[Presentation] F-methyl-curcumin-1 is a potential diagnostic and therapeutic agent for Alzheimer's disease2017
- Author(s)
  Ikuo Tooyama, Anarmaa Mendsaikhan, Daijiro Yanagisawa, Hiroyasu Taguchi
- Organizer
  第４回モンゴル神経科学会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03560
[Presentation] アルツハイマー病モデルマウスにおける脳特異的タンパク質α1‐chimaerinの発現2017
- Author(s)
  加藤智子、小西吉裕、下濱俊、BEACH T. G.、赤津裕康
- Organizer
  第36回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08725
[Presentation] ピコリルアミン誘導体化法による短鎖脂肪酸のLC‐ESI‐MS/MS分析法の開発:腸内細菌叢解析への応用2017
- Author(s)
  長友涼介、岡田泰毅、筒井陽仁、赤津裕康
- Organizer
  第30回バイオメディカル分析科学シンポジウム
- Data Source
  KAKENHI-PROJECT-17K08725
[Presentation] Application of double MR imaging for analysis of senile plaques and Aβ oligomers in the brain of APP/PS1 double transgenic mouse model of Alzheimer’s disease2017
- Author(s)
  Ikuo Tooyama, Daijiro Yanagisawa, Hiroyasu Taguchi
- Organizer
  中国微小脳循環学会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03560
[Presentation] Tau imaging using fluorine-19 MRI in a mouse model of tauopathy2017
- Author(s)
  Daijiro Yanagisawa, Nor Faeizah Ibrahim, Hiroyasu Taguchi, Shigehiro Morikawa, Koichi Hirao, Nobuaki Shirai, Takayuki Sogabe, Ikuo Tooyama
- Organizer
  国際アルツハイマー病学会2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03560
[Presentation] Investigation on the effect of aminolevulinic acid on intestinal environment of aging mice2017
- Author(s)
  *Akatsu H, Arai　S, Tanaka　T, Kamiya　A, Arakawa　K, Masaki Y, Tanaka　H, Kanematsu　T, Ohara　H, Inoue　K, J.-Z. Xia, Maruyama　M.
- Organizer
  ESPEN(欧州静脈経腸栄養学会)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08725
[Presentation] MCIとアルツハイマー病の血液バイオマーカーとしての補体タンパク質プロファイル2017
- Author(s)
  劉珊、鈴木秀昭、目野浩二、赤津裕康、松川則之
- Organizer
  第36回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-16H06277
[Presentation] 美原記念病院ブレインバンクからの年次報告2017
- Author(s)
  田野光俊, 田村未来, 佐藤愛美, 青柳真一, 飯島仁美, 谷津隆之, 諏訪部桂, 木村浩晃, 高橋陽子, 相澤勝健, 赤津祐康, 村山繁雄, 高尾昌樹, 美原盤, 美原恵理, 美原樹
- Organizer
  第58回日本神経病理学会総会学術研究会
- Data Source
  KAKENHI-PROJECT-16H06277
[Presentation] Fmoc誘導体化LC‐MS/MSを用いたヒト脳脊髄液中のアミノ酸骨格代謝系の網羅的定量分析2017
- Author(s)
  六車宜央、筒井陽仁、赤津裕康
- Organizer
  第30回バイオメディカル分析科学シンポジウム
- Data Source
  KAKENHI-PROJECT-17K08725
[Presentation] In vivo detection of tau pathology by fluorine-19 MR imaging in a mouse model of tauopathy2017
- Author(s)
  aijiro Yanagisawa, Nor Faeizah Ibrahim, Hiroyasu Taguchi, Shigehiro Morikawa, Ikuo Tooyama
- Organizer
  第12回日本分子イメージング学会
- Data Source
  KAKENHI-PROJECT-17H03560
[Presentation] 死後脳内において高頻度にコピー数多型(CNV)が観察された統合失調症3症例の臨床的特徴について2017
- Author(s)
  長岡敦子、國井泰人、松本純弥、和田明、日野瑞城、丹羽真一、那波宏之、高橋均、柿田明美、赤津裕康、橋詰良夫、山本左近、尾関祐二、矢部博興
- Organizer
  第12回日本統合失調症学会
- Data Source
  KAKENHI-PROJECT-16H06277
[Presentation] 死後脳内において高頻度にコピー数多型(CNV)が観察された統合失調症3症例の臨床的特徴について2017
- Author(s)
  長岡敦子, 國井泰人, 松本純弥, 和田明, 日野瑞城, 丹羽真一, 那波宏之, 高橋均, 柿田明美, 赤津裕康, 橋詰良夫, 山本左近, 尾関祐二, 矢部博興
- Organizer
  第12回日本統合失調症学会
- Data Source
  KAKENHI-PROJECT-16H06277
[Presentation] 福祉村Brain Bank 2016年次報告2017
- Author(s)
  兼坂岳志, 小川倫弘, 赤津裕康, 谷口知恵, 山本左近, 山本孝之, 高尾昌樹, 村山繁雄, 橋詰良夫
- Organizer
  第58回日本神経病理学会総会学術研究会
- Data Source
  KAKENHI-PROJECT-16H06277
[Presentation] 美原記念病院ブレインバンクからの年次報告(2016年度)2017
- Author(s)
  田野光敏, 田村未来, 佐藤愛海, 青柳真一, 飯島仁美, 谷津隆之, 諏訪部桂, 木村浩晃, 高橋陽子, 相澤勝健, 赤津裕康, 村山繁雄, 高尾樹, 美原盤, 美原恵里, 美原樹
- Organizer
  第58回日本神経病理学会総会学術研究会
- Data Source
  KAKENHI-PROJECT-16H06277
[Presentation] 2016 annual report of Japanese brain bank for neuroscience research.2017
- Author(s)
  Obata M, Murayama S, Takao M, Akatsu Y, Saito Y
- Organizer
  The 40th Annual Meeting of the Japan Neuroscience Society
- Data Source
  KAKENHI-PROJECT-16H06277
[Presentation] Fmoc誘導体化LC-MS/MSを用いたヒト脳脊髄液中のアミノ酸骨格代謝系の網羅的定量分析2017
- Author(s)
  六車宜央、筒井陽仁、赤津裕康
- Organizer
  第30回バイオメディカル分析科学シンポジウム
- Data Source
  KAKENHI-PROJECT-16H06277
[Presentation] MCIとアルツハイマー病の血液バイオマーカーとしての補体タンパク質プロファイル2017
- Author(s)
  劉珊、鈴木秀昭、目野浩二、赤津裕康、松川則之
- Organizer
  第36回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08725
[Presentation] LC-HR/MSによるアルツハイマー病患者脳脊髄液のキラルメタボロミクス2017
- Author(s)
  高山卓大、水野初、井之上浩一、赤津裕康、豊岡利正、轟木堅一郎
- Organizer
  第42回日本医用マススペクトル学会年会
- Data Source
  KAKENHI-PROJECT-16H06277
[Presentation] 認知症内患者の肺炎による死亡の検討 : システマティックレビュー&メタアナリシス2017
- Author(s)
  間辺利江、水上勝義、赤津裕康、工藤宏一郎
- Organizer
  第59回日本老年医学会学術集会
- Data Source
  KAKENHI-PROJECT-16H06277
[Presentation] アルツハイマー病ヒト脳とアルツハイマー病モデルマウス脳に置けるα1-chimaerinの発現と局在について2017
- Author(s)
  加藤智子、小西吉裕、椎野顕彦、下濱俊、Beach Thomas G、赤津裕康、遠山育夫
- Organizer
  第58回日本神経病理学会学術研究会
- Data Source
  KAKENHI-PROJECT-16H06277
[Presentation] 美原記念病院ブレインバンクからの年次報告(2016年)2017
- Author(s)
  田野光敏、田村未来、佐藤愛海、青柳真一、飯島仁美、谷津隆之、諏訪部桂、木村浩晃、高橋陽子、相沢勝健、赤津裕康、村山繁雄、高尾昌樹、美原盤、美原恵里、美原樹
- Organizer
  第58回日本神経病理学会学術研究会
- Data Source
  KAKENHI-PROJECT-16H06277
[Presentation] 成人型neuronal ceroid lipofuscinosisの剖検例2017
- Author(s)
  橋詰良夫、兼坂岳志、小川倫弘、谷口知恵、園田尚子、赤津裕康、吉田眞理
- Organizer
  第45回臨床神経懇話会
- Data Source
  KAKENHI-PROJECT-16H06277
[Presentation] 安定同位体誘導体化を基盤とする高精度キラルメタボロミクスの開発とアルツハイマー病患者CSF解析2017
- Author(s)
  高山卓大、水野初、豊岡利正、井之上浩一、赤津裕康、轟木堅一郎
- Organizer
  第30回バイオメディカル分析科学シンポジウム
- Data Source
  KAKENHI-PROJECT-16H06277
[Presentation] LC-MS/MSを用いたヒト脳脊髄液中におけるアルツハイマー病の新規バイオマーカー探索2017
- Author(s)
  野田巧、六車宜央、筒井陽仁、赤津裕康、井之上浩一
- Organizer
  第42回日本医用マススペクトル学会年会
- Data Source
  KAKENHI-PROJECT-16H06277
[Presentation] 安定同位体誘導体化を基盤とする高精度キラルメタボロミクスの開発とアルツハイマー病患者CSF解析2017
- Author(s)
  高山卓大、水野初、豊岡利正、井之上浩一、赤津裕康、轟木堅一郎
- Organizer
  第30回バイオメディカル分析科学シンポジウム
- Data Source
  KAKENHI-PROJECT-17K08725
[Presentation] 脳内Aβ蓄積規定因子Kinesin Light Chain-1 variant E (KLC1vE)2016
- Author(s)
  森原剛史　佐藤真広　赤津裕康　Luc　Paillard　林紀行　木村展之　鈴木利治　橋本亮太　柳田寛太　武田雅俊
- Organizer
  第35回日本認知症学会学術集会
- Place of Presentation
  東京
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-26461747
[Presentation] Aβ脳蓄積の鍵の一つとなる遺伝子産物の同定とアルツハイマー病血中バイオマーカーの開発2016
- Author(s)
  森原剛史、佐藤真広、赤津裕康、林紀行、Michael　Silverman、Luc Paillard, 木村展之、橋本亮太、鈴木利治、柳田寛太、紙野晃人、武田雅
- Organizer
  第58回日本老年医学会
- Place of Presentation
  金沢
- Year and Date
  2016-06-08
- Data Source
  KAKENHI-PROJECT-26461747
[Presentation] 脳内Aβ蓄積量を規定する遺伝子産物KLC1vEの同定とその機能解析2015
- Author(s)
  森原剛史　佐藤真広　赤津　Luc　Paillard　林紀行　木村展之　鈴木利治　橋本亮太　柳田寛太　武田雅俊
- Organizer
  第34回日本認知症学会学術集会
- Place of Presentation
  青森
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-26461747
[Presentation] Transcriptome analysis of distinct mouse strains reveals KLC1 splice variant E as an Abeta accumulation modifier2015
- Author(s)
  T. Morihara, M. Sato, M. Silverman, H. Akatsu, N. Hayashi, M.. Yanagida, R. Hashimoto, H. T Suzuki T Tsunoda . Kamino, M. Takeda
- Organizer
  第38回　日本神経科学会
- Place of Presentation
  神戸
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-26461747
[Presentation] 脳内Aβ蓄積量を規定する遺伝子産物KLC1vEの同定とその機能解析2015
- Author(s)
  "森原剛史佐藤真広赤津 Luc 林紀行橋本亮太柳田寛太山口角田達彦武田雅俊 "
- Organizer
  第60回　日本人類遺伝学会　　2015.10.14-17
- Place of Presentation
  東京
- Year and Date
  2015-10-14
- Data Source
  KAKENHI-PROJECT-26461747
[Presentation] アルツハイマー病とアンギオテンシン変換酵素遺伝子多型の関連（連続病理解剖症例を用いて）2014
- Author(s)
  赤津裕康、山本孝之、大原弘隆
- Organizer
  日本老年学会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-24500431
[Presentation] The dynamics and function of two glutamate receptor delta subunits.2014
- Author(s)
  C.Nakamoto, I.Watanabe,R.Natsume,E.Nakatsukasa,K.Konno,M.Abe,M.Watanabe,K.Sakimura
- Organizer
  SFN2014
- Place of Presentation
  ワシントン（アメリカ）
- Year and Date
  2014-11-16
- Data Source
  KAKENHI-PROJECT-221S0003
[Presentation] 福祉村Brain Bank 年間報告2012
- Author(s)
  赤津裕康
- Organizer
  第53回日本神経病理学会総会学術研究会
- Place of Presentation
  朱鷺メッセ（新潟）
- Data Source
  KAKENHI-PROJECT-24500431
[Presentation] Detection of β-Amyloid by Florbetaben PET: Histopathological Verification in a Global Phase 3 Clinical Trial.2012
- Author(s)
  Schulz-Schaeffer W, Hoffmann A, Sabri O, John Seibyl, Akatsu H, Takao M, Beach T, Murayama S, Ghetti B, Ironside J, Leverenz J, Roth K, Reininger C, Sabbagh M
- Organizer
  88th Annual Meeting of the American Association of Neuropathologists.
- Place of Presentation
  Chicago, USA.
- Data Source
  KAKENHI-PROJECT-221S0003
[Presentation] The Clinicopathological Analysis of Autopsy-Confirmed Alzheimer’s Disease.2012
- Author(s)
  Akatsu H
- Organizer
  国際アルツハイマー学会
- Place of Presentation
  バルセロナ国際会議場（スペイン・バルセロナ）
- Data Source
  KAKENHI-PROJECT-24500431
[Presentation] A negative florbetaben PET scan reliably excludes amyloid pathology as confirmed by histopathology in a large Phase 3 trial.
- Author(s)
  Sabbagh, M., Seibyl, J., Stephens, A., Barthel, H., Ishii, K., Takao, M., Akatsu, H., Murayama, S., Christopher, Rowe., Ana, Catafau., Walter, Schulz-Schaeffer., Sabri, O.
- Organizer
  The 66th AAN Annual Meeting.
- Place of Presentation
  Philadelphia, PA（USA）
- Year and Date
  2014-04-26 – 2014-05-03
- Data Source
  KAKENHI-PROJECT-221S0003
[Presentation] Wide distribution of seeding actvity in sporadic CJD patients.
- Author(s)
  Takatsuki, H., Satoh, K., Atarashi, R., Sano, K., Iwasaki, Y., Yoshida, M., Takao, M., Mihara, B., Murayama, S., Nishida, N
- Organizer
  Asian Pacific Prion Symposium 2014 in Jeju.
- Place of Presentation
  Jeju（Korea）
- Year and Date
  2014-07-06 – 2014-07-07
- Data Source
  KAKENHI-PROJECT-221S0003
[Presentation] 臨床的に前頭側頭型認知症(FTD)/筋萎縮性側策硬化症を伴うFTD (ALSD/MND with FTD)が疑われた58歳男性
- Author(s)
  赤津裕康
- Organizer
  日本神経病理学会関東地方会
- Place of Presentation
  順天堂大学（東京）
- Data Source
  KAKENHI-PROJECT-24500431
[Presentation] アルツハイマー病とアンギオテンシン変換酵素遺伝子多型の関連（連続剖検脳症例を用いて）
- Author(s)
  赤津裕康、山本孝之、大原弘隆
- Organizer
  第５６回日本老年医学会学術集会・総会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2014-06-12 – 2014-06-14
- Data Source
  KAKENHI-PROJECT-24500431
[Presentation] 臨床的に前頭側頭型認知症(FTD)/筋萎縮性側策硬化症を伴うFTD (ALSD/MND with FTD)が疑われた58歳男性
- Author(s)
  赤津裕康
- Organizer
  名古屋神経病理アカデミー
- Place of Presentation
  大日本製薬名古屋支社（愛知）
- Data Source
  KAKENHI-PROJECT-24500431
[Presentation] Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid beta pathology modifier in Alzheimer’s disease: A mouse-to-human translational approach to complex diseases
- Author(s)
  T. Morihara, M. Sato, M. Silverman, H. Akatsu, N. Hayashi, M. Yokokoji, K. Yanagida, R. Hashimoto, H. Yamamori, T. Tsunoda, Y. Yamaguchi, K. Kamino, M. Takeda
- Organizer
  64th Annual Meeting of the American Society of Human Genetics (ASHG 2014)
- Place of Presentation
  San Diego, USA
- Year and Date
  2014-10-18 – 2014-10-22
- Data Source
  KAKENHI-PROJECT-26461747
[Presentation] A negative florbetaben PET scan reliably excludes amyloid pathology as confirmed by histopathology.
- Author(s)
  Stephens, A., Barthel, H., Ishii, K., Takao, M., Akatsu, H., Murayama, S., Rowe, C., Koglin, N., Catafau, A., Schulz-Schaeffer, W., Sabbagh, M., Sabri, O.，Seibyl, J.
- Organizer
  Alzheimer’s Association International Conference 2014.
- Place of Presentation
  Copenhagen（Denmark）
- Year and Date
  2014-07-12 – 2014-07-17
- Data Source
  KAKENHI-PROJECT-221S0003
[Presentation] Transcriptome analysis of distinct mouse strains reveals KLC1 splice variant E as an Abeta accumulation modifier
- Author(s)
  T. Morihara, N. Hayashi, H. Akatsu, M. Silverman, M. Yokokoji, N. Kimura, M. Sato, K. Kamino, Y. Yamagichi, T. Tsunoda, T. Tanaka, M. Takeda
- Organizer
  Alzheimer’s Assosication International Conference (AAIC)
- Place of Presentation
  Copenhagen,Denmark
- Year and Date
  2014-07-12 – 2014-07-17
- Data Source
  KAKENHI-PROJECT-26461747
[Presentation] High-resolution crystal Structure of an ABC multidrug exporter from Cyanidioschyzon merolae, a thermophilic unicellular eukaryote.
- Author(s)
  A. Kodan., T. Yamaguchi, T. Nakatsu, K. Sakiyama, C.J. Hipolito, A. Fujioka, R. Hirokane, Y. Kimura, H. Suga, K. Ueda, and H. Kato
- Organizer
  5th FEBS special meeting “ATP-Binding Cassette (ABC) Proteins
- Place of Presentation
  Innsbruck, Austria
- Year and Date
  2014-03-09 – 2014-03-14
- Data Source
  KAKENHI-PROJECT-25221203
[Presentation] 遺伝子研究から見えてきたこと：アルツハイマー病理形成の原因としての細胞内輸送障害
- Author(s)
  森原剛史、赤津裕康、佐藤真広、鈴木利治、木村展之、林紀行、柳田寛太、西道隆臣、紙野晃人、武田雅俊
- Organizer
  第３３回　日本認知症学会
- Place of Presentation
  パシフィコ横浜会議センター（神奈川）
- Year and Date
  2014-11-29 – 2014-12-01
- Invited
- Data Source
  KAKENHI-PROJECT-26461747
[Presentation] 質量分析を基盤とする認知症患者病理資料のノンターゲット多変量解析
- Author(s)
  井之上浩一、赤津裕康、山本誠、土屋浩史、宮崎康人、松川則之、橋詰良夫、道川誠、山本孝之、豊岡利正
- Organizer
  第33回日本認知症学会学術集会
- Place of Presentation
  パシフィコ横浜会議センター
- Year and Date
  2014-11-29 – 2014-12-01
- Data Source
  KAKENHI-PROJECT-24500431
[Presentation] ヒト鼻粘膜でのAβ解析と臨床補助診断の検討
- Author(s)
  赤津裕康
- Organizer
  第２回日本認知症予防学会学術集会
- Place of Presentation
  北九州国際会議場（福岡）
- Data Source
  KAKENHI-PROJECT-24500431

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253. OHARA Noriyuki

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254. KONO Nozomu

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256. KIMURA Noriyuki

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258. Todoroki Kenichiro

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260. TAGAMI Shinji

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261. KAZUI Hiroaki

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262. HATA Saori

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264. Niwa Atsushi

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270. Morikawa Shigehiro

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279. 中務眞人

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281. 中津亨

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287. 福本学

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295. 中川誠人

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324. 池田将樹

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325. 古川勝敏

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AKATSU Hiroyasu 赤津 裕康

Research Projects

Research Products

Co-Researchers

Creating a fall prevention program that the elderly can evaluate their walk-style by developing our three-dimensional acceleration sensorPrincipal InvestigatorOngoing

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Development of AI technology to detect prion activity of pathogenic proteins in nasal mucosa and its application to diagnosis of dementiaOngoing

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International cooperative study for spatial-temporal disease clustering and risk factors on emerging infectious diseasesOngoing

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A Cross-Sectional Study on Disease and Regional Diversity of Cognitive Impairment in Elderly Using Speech Analysis and Cerebral Blood Flow ActivationOngoing

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ラクトフェリンによる炎症性腸疾患の発症予防と寛解維持および発がん予防効果Ongoing

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ヒト脳内での２段階にわたるアミロイドβ蓄積の機序の解明Ongoing

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The research of pathological condition for clinical diagnosis of tangle only dementiaPrincipal Investigator

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Development of online system about Advanced Directive of Living Will and its efficacy assessmentOngoing

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Simultaneous analysis of A&#223; oligomers, A&#223; fibrils and phosphrylated tau protein using fluroine-MRIOngoing

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コホート・生体試料支援プラットフォームOngoing

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AKATSU Hiroyasu 赤津裕康

Simultaneous analysis of Aß oligomers, Aß fibrils and phosphrylated tau protein using fluroine-MRIOngoing